Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_010_L01
(804 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chrom... 134 4e-31
sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein 99 1e-20
sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regul... 99 1e-20
sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regul... 99 2e-20
sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein) 95 3e-19
sp|Q9UN36|NDRG2_HUMAN NDRG2 protein (Syld709613 protein) 88 2e-17
sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein) 87 4e-17
sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein 81 3e-15
sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-rela... 80 5e-15
sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-relate... 78 3e-14
>sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chromosome X
Length = 325
Score = 134 bits (336), Expect = 4e-31
Identities = 73/219 (33%), Positives = 115/219 (52%), Gaps = 2/219 (0%)
Frame = +2
Query: 2 LIMTTLNTKYCKTLTFYIEGTRSTN--EVAILTVHDIGCNHTQYVDFIKHSCMETLAPRC 175
L M + + C L Y++G + ILTVHDIG NH +V F+ H M T+ +
Sbjct: 6 LQMVVVQAQNCGVLHVYVQGNLEERGGKTIILTVHDIGTNHKSFVRFVNHPSMATVKEKA 65
Query: 176 VWFNVDLPGQGINDPDLPSDFTYPTMQQIAEDLIECIGMLSISHLIVFGEGAGANILARM 355
++ +V +PGQ N D DF PT+ I +DL + + I FGEG GANI+ R
Sbjct: 66 IFLHVCVPGQEDNSADFFGDF--PTLDGIGDDLSAVLDKFEVKSAIAFGEGVGANIICRF 123
Query: 356 AMTGDERILGAVLLNCVGSTPNLVESLKDKIIGWKLSTIGMTSSTENYLVVHRFGVMNNL 535
AM RI+G VL++C +T ++E K+K++ +L M+ +YL+ H+FG +
Sbjct: 124 AMGHPNRIMGIVLVHCTSTTAGIIEYCKEKVMNMRLENSIMSDGAWDYLLAHKFGGESKS 183
Query: 536 QSDEELSTMINNYKKFLRDTFNTKNLHGYVTSYMNRSNL 652
+ + Y + L+ T N KNL Y+ ++ R++L
Sbjct: 184 RQE---------YLEELKATLNPKNLSKYLVAFTKRTDL 213
>sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein
Length = 375
Score = 99.0 bits (245), Expect = 1e-20
Identities = 70/217 (32%), Positives = 105/217 (48%), Gaps = 3/217 (1%)
Frame = +2
Query: 53 IEGTRSTNEVAILTVHDIGCNHTQYVD-FIKHSCMETLAPRCVWFNVDLPGQGINDPDLP 229
I G N ILT HDIG NH + F M+ + +VD PGQ P P
Sbjct: 46 IRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFP 105
Query: 230 SDFTYPTMQQIAEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVG 409
+ + YPTM ++AE L + LS+ +I G GAGA IL+R A+ E + G VL+N
Sbjct: 106 TGYQYPTMDELAEMLPPVLTHLSLKSIIGIGVGAGAYILSRFALNHPELVEGLVLIN--- 162
Query: 410 STPNLVESLKDKIIGWKLSTI-GMTSSTENYLVVHRFGVMNNLQSDEELSTMINNYKKFL 586
V+ I W S + G+T++ + ++ H FG LQ++ +L I Y+ +
Sbjct: 163 -----VDPCAKGWIDWAASKLSGLTTNVVDIILAHHFG-QEELQANLDL---IQTYRMHI 213
Query: 587 RDTFNTKNLHGYVTSYMNRSNL-IDKSMSISQDNDSR 694
N NL ++ SY R +L I++ + DN S+
Sbjct: 214 AQDINQDNLQLFLNSYNGRRDLEIERPILGQNDNKSK 250
>sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regulated gene 1 protein) (Protein
Ndr1)
Length = 394
Score = 99.0 bits (245), Expect = 1e-20
Identities = 70/252 (27%), Positives = 109/252 (43%), Gaps = 4/252 (1%)
Frame = +2
Query: 59 GTRSTNEVAILTVHDIGCNH-TQYVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLPSD 235
GT N ILT HDIG NH T Y M+ + +VD PGQ P P
Sbjct: 50 GTPKGNRPVILTYHDIGMNHKTCYNPLFNSEDMQEITQHFAVCHVDAPGQQDGAPSFPVG 109
Query: 236 FTYPTMQQIAEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGST 415
+ YP+M Q+AE L + + +I G GAGA IL R A+ E + G VL+N
Sbjct: 110 YMYPSMDQLAEMLPGVLHQFGLKSVIGMGTGAGAYILTRFALNNPEMVEGLVLMNVNPCA 169
Query: 416 PNLVESLKDKIIGWKLSTIGMTSSTENYLVVHRFG---VMNNLQSDEELSTMINNYKKFL 586
++ KI GW T + + +V H FG + NN++ +++ Y++ +
Sbjct: 170 EGWMDWAASKISGW-------TQALPDMVVSHLFGKEEIHNNVE-------VVHTYRQHI 215
Query: 587 RDTFNTKNLHGYVTSYMNRSNLIDKSMSISQDNDSRQDEKQKMKKGKYREMEKERKSTKC 766
+ N NLH ++++Y +R +L E+E+ T
Sbjct: 216 LNDMNPSNLHLFISAYNSRRDL---------------------------EIERPMPGTHT 248
Query: 767 PSIRCPMLFISG 802
+++CP L + G
Sbjct: 249 VTLQCPALLVVG 260
>sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regulated gene 1 protein)
(Differentiation-related gene 1 protein) (DRG1)
(Reducing agents and tunicamycin-responsive protein)
(RTP) (Nickel-specific induction protein Cap43) (Rit42)
Length = 394
Score = 98.6 bits (244), Expect = 2e-20
Identities = 70/249 (28%), Positives = 109/249 (43%), Gaps = 1/249 (0%)
Frame = +2
Query: 59 GTRSTNEVAILTVHDIGCNH-TQYVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLPSD 235
GT N ILT HDIG NH T Y + M+ + +VD PGQ P+
Sbjct: 50 GTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAG 109
Query: 236 FTYPTMQQIAEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVGST 415
+ YP+M Q+AE L + + +I G GAGA IL R A+ E + G VL+N
Sbjct: 110 YMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCA 169
Query: 416 PNLVESLKDKIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEELSTMINNYKKFLRDT 595
++ KI GW T + + +V H FG +QS+ E +++ Y++ + +
Sbjct: 170 EGWMDWAASKISGW-------TQALPDMVVSHLFG-KEEMQSNVE---VVHTYRQHIVND 218
Query: 596 FNTKNLHGYVTSYMNRSNLIDKSMSISQDNDSRQDEKQKMKKGKYREMEKERKSTKCPSI 775
N NLH ++ +Y +R +L E+E+ T ++
Sbjct: 219 MNPGNLHLFINAYNSRRDL---------------------------EIERPMPGTHTVTL 251
Query: 776 RCPMLFISG 802
+CP L + G
Sbjct: 252 QCPALLVVG 260
>sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein)
Length = 375
Score = 94.7 bits (234), Expect = 3e-19
Identities = 69/216 (31%), Positives = 103/216 (47%), Gaps = 2/216 (0%)
Frame = +2
Query: 53 IEGTRSTNEVAILTVHDIGCNHTQ-YVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLP 229
I G N ILT HDIG NH + F M+ + +VD PGQ P P
Sbjct: 46 IRGLPKGNRPVILTYHDIGLNHKSCFNTFFNFEDMQEITQHFAVCHVDAPGQQEAAPSFP 105
Query: 230 SDFTYPTMQQIAEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVG 409
+ + YPTM ++AE L + LS+ +I G GAGA IL+R A+ E + G VL+N
Sbjct: 106 TGYQYPTMDELAEMLPPVLTHLSMKSIIGIGVGAGAYILSRFALNHPELVEGLVLIN--- 162
Query: 410 STPNLVESLKDKIIGWKLSTI-GMTSSTENYLVVHRFGVMNNLQSDEELSTMINNYKKFL 586
++ I W S + G T++ + ++ H FG LQ++ +L I Y+ +
Sbjct: 163 -----IDPCAKGWIDWAASKLSGFTTNIVDIILAHHFG-QEELQANLDL---IQTYRLHI 213
Query: 587 RDTFNTKNLHGYVTSYMNRSNLIDKSMSISQDNDSR 694
N +NL ++ SY R +L + I ND+R
Sbjct: 214 AQDINQENLQLFLGSYNGRRDL-EIERPILGQNDNR 248
>sp|Q9UN36|NDRG2_HUMAN NDRG2 protein (Syld709613 protein)
Length = 371
Score = 88.2 bits (217), Expect = 2e-17
Identities = 66/210 (31%), Positives = 100/210 (47%), Gaps = 5/210 (2%)
Frame = +2
Query: 38 TLTFYIEGTRSTNEVAILTVHDIGCNHTQ-YVDFIKHSCMETLAPRCVWFNVDLPGQGIN 214
++TF + GT AILT HD+G N+ + + M+ + V +VD PG
Sbjct: 49 SVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEG 108
Query: 215 DPDLPSDFTYPTMQQIAEDLIECI-GMLSISHLIVFGEGAGANILARMAMTGDERILGAV 391
P P + YP++ Q+A D+I C+ L+ S +I G GAGA ILAR A+ + + G V
Sbjct: 109 APVFPLGYQYPSLDQLA-DMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLV 167
Query: 392 LLNCVGSTPNLVESLKDKIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEEL---STM 562
L+N + ++ K+ G+TSS ++ H F S EEL S +
Sbjct: 168 LINIDPNAKGWMDWAAHKL-------TGLTSSIPEMILGHLF-------SQEELSGNSEL 213
Query: 563 INNYKKFLRDTFNTKNLHGYVTSYMNRSNL 652
I Y+ + N N+ Y SY NR +L
Sbjct: 214 IQKYRNIITHAPNLDNIELYWNSYNNRRDL 243
>sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein)
Length = 371
Score = 87.4 bits (215), Expect = 4e-17
Identities = 65/210 (30%), Positives = 102/210 (48%), Gaps = 5/210 (2%)
Frame = +2
Query: 38 TLTFYIEGTRSTNEVAILTVHDIGCNHTQ-YVDFIKHSCMETLAPRCVWFNVDLPGQGIN 214
++TF + GT AI T HD+G N+ + + M+ + V +VD PG
Sbjct: 49 SVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFRFGDMQEIIQNFVRVHVDAPGMEEG 108
Query: 215 DPDLPSDFTYPTMQQIAEDLIECI-GMLSISHLIVFGEGAGANILARMAMTGDERILGAV 391
P P + YP++ Q+A D+I CI L+ S +I G GAGA IL+R A+ + + G V
Sbjct: 109 APVFPLGYQYPSLDQLA-DMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLV 167
Query: 392 LLNCVGSTPNLVESLKDKIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEEL---STM 562
L+N + ++ K+ G+TSS + ++ H F S EEL S +
Sbjct: 168 LINIDPNAKGWMDWAAHKL-------TGLTSSIPDMILGHLF-------SQEELSGNSEL 213
Query: 563 INNYKKFLRDTFNTKNLHGYVTSYMNRSNL 652
I Y+ ++ N +N+ Y SY NR +L
Sbjct: 214 IQKYRGIIQHAPNLENIELYWNSYNNRRDL 243
>sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein
Length = 352
Score = 81.3 bits (199), Expect = 3e-15
Identities = 56/204 (27%), Positives = 97/204 (47%), Gaps = 4/204 (1%)
Frame = +2
Query: 53 IEGTRSTNEVAILTVHDIGCNHTQ-YVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLP 229
I G+ N AILT HD+G NH + F M+ + V +VD PGQ + P
Sbjct: 22 IRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFP 81
Query: 230 SDFTYPTMQQIAEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVG 409
+ +P+M+Q+A L + ++I G GAGA +LA+ A+ + + G VL+N
Sbjct: 82 QGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDP 141
Query: 410 STPNLVESLKDKIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEEL---STMINNYKK 580
+ ++ K+ G+TS+ + ++ H F S EEL + ++ +Y++
Sbjct: 142 NGKGWIDWAATKL-------SGLTSTLPDTVLSHLF-------SQEELVNNTELVQSYRQ 187
Query: 581 FLRDTFNTKNLHGYVTSYMNRSNL 652
+ + N NL + Y +R +L
Sbjct: 188 QISNVVNQANLQLFWNMYNSRRDL 211
>sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-related molecule 1) (Vascular
smooth muscle cell associated protein 8) (SMAP-8)
Length = 352
Score = 80.5 bits (197), Expect = 5e-15
Identities = 56/204 (27%), Positives = 97/204 (47%), Gaps = 4/204 (1%)
Frame = +2
Query: 53 IEGTRSTNEVAILTVHDIGCNHTQ-YVDFIKHSCMETLAPRCVWFNVDLPGQGINDPDLP 229
I G+ N AILT HD+G NH + F M+ + V +VD PGQ + P
Sbjct: 22 IRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFP 81
Query: 230 SDFTYPTMQQIAEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVG 409
+ +P+M+Q+A L + ++I G GAGA +LA+ A+ + + G VL+N
Sbjct: 82 QGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDP 141
Query: 410 STPNLVESLKDKIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEEL---STMINNYKK 580
+ ++ K+ G+TS+ + ++ H F S EEL + ++ +Y++
Sbjct: 142 NGKGWIDWAATKL-------SGLTSTLPDTVLSHLF-------SQEELVNNTELVQSYRQ 187
Query: 581 FLRDTFNTKNLHGYVTSYMNRSNL 652
+ + N NL + Y +R +L
Sbjct: 188 QIGNVVNQANLQLFWNMYNSRRDL 211
>sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-related molecule 1)
Length = 352
Score = 77.8 bits (190), Expect = 3e-14
Identities = 55/204 (26%), Positives = 97/204 (47%), Gaps = 4/204 (1%)
Frame = +2
Query: 53 IEGTRSTNEVAILTVHDIGCNHTQYVDFIKH-SCMETLAPRCVWFNVDLPGQGINDPDLP 229
I G+ N AILT HD+G NH + + + M+ + V +VD PGQ + P
Sbjct: 22 IRGSPKGNRPAILTYHDVGLNHKLCFNTLFNLEDMQEITKHFVVCHVDAPGQQVGASQFP 81
Query: 230 SDFTYPTMQQIAEDLIECIGMLSISHLIVFGEGAGANILARMAMTGDERILGAVLLNCVG 409
+ +P+M+Q+A L + ++I G GAGA +LA+ A+ + + G VL+N
Sbjct: 82 QGYQFPSMEQLATMLPNVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDP 141
Query: 410 STPNLVESLKDKIIGWKLSTIGMTSSTENYLVVHRFGVMNNLQSDEEL---STMINNYKK 580
+ ++ K+ G+TS+ + ++ H F S EEL + ++ +Y++
Sbjct: 142 NGKGWIDWAATKL-------SGLTSTLPDTVLSHLF-------SQEELVNNTELVQSYRQ 187
Query: 581 FLRDTFNTKNLHGYVTSYMNRSNL 652
+ N NL + Y +R +L
Sbjct: 188 QISSVVNQANLQLFWNMYNSRRDL 211
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,803,918
Number of Sequences: 369166
Number of extensions: 1760209
Number of successful extensions: 5257
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4989
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5237
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)