Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_010_G21
(549 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-... 214 9e-56
sp|Q26563|CATC_SCHMA Cathepsin C precursor 213 2e-55
sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-... 211 9e-55
sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-... 204 1e-52
sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-... 203 3e-52
sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I)... 200 2e-51
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 103 4e-22
sp|Q8IIJ9|CATC_PLAF7 Probable cathepsin C precursor 102 6e-22
sp|P92132|CATB2_GIALA Cathepsin B-like CP2 precursor (Cathe... 101 1e-21
sp|P92133|CATB3_GIALA Cathepsin B-like CP3 precursor (Cathe... 100 4e-21
>sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 214 bits (546), Expect = 9e-56
Identities = 96/161 (59%), Positives = 122/161 (75%), Gaps = 1/161 (0%)
Frame = +1
Query: 1 AGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVK 180
AGK+A+DFG+ +E+C PY G + C +DC RY+++ Y Y+GG+YG NE LM++ELV
Sbjct: 307 AGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVH 366
Query: 181 NGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSG 357
+GP+AV FEVYDDF+ Y G+YHH T + FNPFELTNHAVL+VGYG +++SG
Sbjct: 367 HGPMAVAFEVYDDFLHYKKGIYHH-------TGLRDPFNPFELTNHAVLLVGYGTDSASG 419
Query: 358 EKFWIVKNSWGNGWGENGYFRIRRGNDECGIESLGVASEPI 480
+WIVKNSWG GWGENGYFRIRRG DEC IES+ VA+ PI
Sbjct: 420 MDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPI 460
>sp|Q26563|CATC_SCHMA Cathepsin C precursor
Length = 454
Score = 213 bits (543), Expect = 2e-55
Identities = 99/163 (60%), Positives = 121/163 (74%), Gaps = 2/163 (1%)
Frame = +1
Query: 1 AGKFAEDFGMAQESCNPYKGIN-GKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELV 177
AGK+ EDFG+ Q+ PY G + GKC+ +K+C RY+ T+Y YIGGYYGATNE LM++EL+
Sbjct: 296 AGKYGEDFGLPQKIVIPYTGEDTGKCTVSKNCTRYYTTDYSYIGGYYGATNEKLMQLELI 355
Query: 178 KNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSS 354
NGP VGFEVY+DF Y G+YHH + T + FNPFELTNHAVL+VGYG + S
Sbjct: 356 SNGPFPVGFEVYEDFQFYKEGIYHHT----TVQTDHYNFNPFELTNHAVLLVGYGVDKLS 411
Query: 355 GEKFWIVKNSWGNGWGENGYFRIRRGNDECGIESLGVASEPIL 483
GE +W VKNSWG WGE GYFRI RG DECG+ESLGV +P+L
Sbjct: 412 GEPYWKVKNSWGVEWGEQGYFRILRGTDECGVESLGVRFDPVL 454
>sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 211 bits (537), Expect = 9e-55
Identities = 94/161 (58%), Positives = 121/161 (75%), Gaps = 1/161 (0%)
Frame = +1
Query: 1 AGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVK 180
AGK+A+DFG+ +E+C PY G + C +DC RY+++ Y Y+GG+YG NE LM++ELV
Sbjct: 307 AGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVY 366
Query: 181 NGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSG 357
+GP+AV FEVYDDF+ Y G+YHH T + FNPFELTNHAVL+VGYG +++SG
Sbjct: 367 HGPLAVAFEVYDDFLHYQNGIYHH-------TGLRDPFNPFELTNHAVLLVGYGTDSASG 419
Query: 358 EKFWIVKNSWGNGWGENGYFRIRRGNDECGIESLGVASEPI 480
+WIVKNSWG WGE+GYFRIRRG DEC IES+ VA+ PI
Sbjct: 420 MDYWIVKNSWGTSWGEDGYFRIRRGTDECAIESIAVAATPI 460
>sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain 1;
Dipeptidyl-peptidase I heavy chain 2;
Dipeptidyl-peptidase I heavy chain 3;
Dipeptidyl-peptidase I heavy chain 4;
Dipeptidyl-peptidase I light chain]
Length = 435
Score = 204 bits (519), Expect = 1e-52
Identities = 94/161 (58%), Positives = 122/161 (75%), Gaps = 1/161 (0%)
Frame = +1
Query: 1 AGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVK 180
AGK+A+DFG+ +E+C PY G + C DC RY+++ Y Y+GG+YGA NE LM++ELV+
Sbjct: 280 AGKYAQDFGLVEEACFPYAGSDSPCKPN-DCFRYYSSEYYYVGGFYGACNEALMKLELVR 338
Query: 181 NGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSG 357
+GP+AV FEVYDDF Y G+Y+H T + FNPFELTNHAVL+VGYG +++SG
Sbjct: 339 HGPMAVAFEVYDDFFHYQKGIYYH-------TGLRDPFNPFELTNHAVLLVGYGTDSASG 391
Query: 358 EKFWIVKNSWGNGWGENGYFRIRRGNDECGIESLGVASEPI 480
+WIVKNSWG+ WGE+GYFRIRRG DEC IES+ VA+ PI
Sbjct: 392 MDYWIVKNSWGSRWGEDGYFRIRRGTDECAIESIAVAATPI 432
>sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 203 bits (516), Expect = 3e-52
Identities = 91/161 (56%), Positives = 121/161 (75%), Gaps = 1/161 (0%)
Frame = +1
Query: 1 AGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVK 180
AGK+A+DFG+ +ESC PY + C ++C RY++++Y Y+GG+YG NE LM++ELVK
Sbjct: 306 AGKYAQDFGVVEESCFPYTAKDSPCKpreNCLRYYSSDYYYVGGFYGGCNEALMKLELVK 365
Query: 181 NGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSG 357
+GP+AV FEV+DDF+ Y G+YHH T FNPFELTNHAVL+VGYG + +G
Sbjct: 366 HGPMAVAFEVHDDFLHYHSGIYHH-------TGLSDPFNPFELTNHAVLLVGYGRDPVTG 418
Query: 358 EKFWIVKNSWGNGWGENGYFRIRRGNDECGIESLGVASEPI 480
++WI+KNSWG+ WGE+GYFRIRRG DEC IES+ VA+ PI
Sbjct: 419 IEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPI 459
>sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 200 bits (508), Expect = 2e-51
Identities = 90/161 (55%), Positives = 119/161 (73%), Gaps = 1/161 (0%)
Frame = +1
Query: 1 AGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVK 180
AGK+A+DFG+ +E+C PY + C ++C RY+++ Y Y+GG+YG NE LM++ELVK
Sbjct: 306 AGKYAQDFGVVEENCFPYTATDAPCKPKENCLRYYSSEYYYVGGFYGGCNEALMKLELVK 365
Query: 181 NGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETSSG 357
+GP+AV FEV+DDF+ Y G+YHH T FNPFELTNHAVL+VGYG + +G
Sbjct: 366 HGPMAVAFEVHDDFLHYHSGIYHH-------TGLSDPFNPFELTNHAVLLVGYGKDPVTG 418
Query: 358 EKFWIVKNSWGNGWGENGYFRIRRGNDECGIESLGVASEPI 480
+WIVKNSWG+ WGE+GYFRIRRG DEC IES+ +A+ PI
Sbjct: 419 LDYWIVKNSWGSQWGESGYFRIRRGTDECAIESIAMAAIPI 459
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 103 bits (256), Expect = 4e-22
Identities = 59/158 (37%), Positives = 83/158 (52%), Gaps = 14/158 (8%)
Frame = +1
Query: 43 CNPYK---GINGKCSTTK------DCKRYFATNY---KYIG--GYYGATNEPLMRMELVK 180
C PY +G C +K C+ ++T Y K+ G Y N ++ E+
Sbjct: 183 CKPYPIAPCTSGNCPESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYA 242
Query: 181 NGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYGETSSGE 360
NGP+ F VY+DF Y GVY H T K+ L HA+ ++G+G T SG
Sbjct: 243 NGPVEAAFSVYEDFYKYKSGVYKH-------TAGKY------LGGHAIKIIGWG-TESGS 288
Query: 361 KFWIVKNSWGNGWGENGYFRIRRGNDECGIESLGVASE 474
+W+V NSWG WGE+G+F+I RG+D+CGIES VA +
Sbjct: 289 PYWLVANSWGVNWGESGFFKIYRGDDQCGIESAVVAGK 326
>sp|Q8IIJ9|CATC_PLAF7 Probable cathepsin C precursor
Length = 700
Score = 102 bits (254), Expect = 6e-22
Identities = 54/140 (38%), Positives = 82/140 (58%), Gaps = 13/140 (9%)
Frame = +1
Query: 97 RYFATNYKYIGGYYGATN---EPLMRMELVKNGPIAVGFEVYDDFMSYSGGVYH-HNFGT 264
R++A ++ Y+GG YG E +M E+ +NGPI FE DF Y+ GVY +F
Sbjct: 541 RWYAKDFNYVGGCYGCNQCNGEKIMMNEIYRNGPIVSSFEASPDFYDYADGVYFVEDFPH 600
Query: 265 RKLTTSK------FGFNPFELTNHAVLVVGYGETS-SGE--KFWIVKNSWGNGWGENGYF 417
+ T + + ++ NHA++++G+GE +G+ K+WI +NSWGNGWG+ GYF
Sbjct: 601 ARRCTIEPKNDGVYNITGWDRVNHAIVLLGWGEEEINGKLYKYWIGRNSWGNGWGKEGYF 660
Query: 418 RIRRGNDECGIESLGVASEP 477
+I RG + GIES + EP
Sbjct: 661 KILRGQNFSGIESQSLFIEP 680
>sp|P92132|CATB2_GIALA Cathepsin B-like CP2 precursor (Cathepsin B-like protease B2)
Length = 300
Score = 101 bits (251), Expect = 1e-21
Identities = 60/163 (36%), Positives = 77/163 (47%), Gaps = 9/163 (5%)
Frame = +1
Query: 7 KFAEDFGMAQESCNPYKG----INGKCST-----TKDCKRYFATNYKYIGGYYGATNEPL 159
KF G + C PYK + G C T + AT+YK G + P
Sbjct: 151 KFLTKTGTTTDECVPYKSGSTTLRGTCPTKCADGSSKVHLATATSYKDYG-----LDIPA 205
Query: 160 MRMELVKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGY 339
M L +GP+ V F V+ DFM Y GVY H +G + HAV +VGY
Sbjct: 206 MMKALSTSGPLQVAFLVHSDFMYYESGVYQHTYGYME-------------GGHAVEMVGY 252
Query: 340 GETSSGEKFWIVKNSWGNGWGENGYFRIRRGNDECGIESLGVA 468
G G +WI+KNSWG WGE+GYFR+ RG ++C IE A
Sbjct: 253 GTDDDGVDYWIIKNSWGPDWGEDGYFRMIRGINDCSIEEQAYA 295
>sp|P92133|CATB3_GIALA Cathepsin B-like CP3 precursor (Cathepsin B-like protease B3)
Length = 299
Score = 99.8 bits (247), Expect = 4e-21
Identities = 56/153 (36%), Positives = 69/153 (45%), Gaps = 4/153 (2%)
Frame = +1
Query: 7 KFAEDFGMAQESCNPYK----GINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMEL 174
+F G + C PY+ G G C T YK + P + L
Sbjct: 150 RFLTKTGTTTDECVPYQSGSTGARGTCPTKCADGSDLPHLYKATKAVDYGLDAPAIMKAL 209
Query: 175 VKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYGETSS 354
GP+ F VY DFM Y GVY H +G + HAV +VGYG
Sbjct: 210 ATGGPLQTAFTVYSDFMYYESGVYQHTYGRVE-------------GGHAVDMVGYGTDDD 256
Query: 355 GEKFWIVKNSWGNGWGENGYFRIRRGNDECGIE 453
G +WI+KNSWG WGE+GYFRI R +ECGIE
Sbjct: 257 GVDYWIIKNSWGPDWGEDGYFRIIRMTNECGIE 289
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,718,430
Number of Sequences: 369166
Number of extensions: 1451164
Number of successful extensions: 4193
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3871
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3970
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3833118120
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)