Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_010_F16
(731 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Int... 54 4e-07
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 51 3e-06
sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6 51 3e-06
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 47 4e-05
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 38 0.024
sp|O70263|LNX1_MOUSE Ubiquitin ligase LNX (Numb-binding pro... 37 0.041
sp|Q8TBB1|LNX1_HUMAN Ubiquitin ligase LNX (Numb-binding pro... 37 0.054
sp|Q8N448|LNX2_HUMAN Ligand of Numb-protein X 2 (Numb-bindi... 37 0.054
sp|Q96PU4|UHRF2_HUMAN Ubiquitin-like containing PHD and RIN... 37 0.071
sp|Q9BRZ2|TRI56_HUMAN Tripartite motif protein 56 (RING fin... 37 0.071
>sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Interleukin 1 signal transducer)
(RING finger protein 85)
Length = 522
Score = 53.9 bits (128), Expect = 4e-07
Identities = 33/125 (26%), Positives = 52/125 (41%), Gaps = 1/125 (0%)
Frame = +3
Query: 42 MSENFERLLKEYKFEIEN-INDDYKCVICKEILINAHSGPCHCNYCYDCLIKFLHGTEKR 218
+S +F ++ Y E + + Y+C IC L A PC +C C+IK + +
Sbjct: 45 LSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHK 104
Query: 219 CPGNSNACKRVXXXXXXXXXXXXXXXEKISKLIVNCPIENCLFKDEVSKIDSHIRVCIFQ 398
CP ++ +I L+V CP E CL K E+ ++ H C F
Sbjct: 105 CPVDNE------ILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFA 158
Query: 399 QIYCP 413
+ CP
Sbjct: 159 LMDCP 163
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 51.2 bits (121), Expect = 3e-06
Identities = 34/136 (25%), Positives = 56/136 (41%), Gaps = 2/136 (1%)
Frame = +3
Query: 72 EYKFEIENINDDYKCVICKEILINAHSGPCHCNYCYDCLIKFLH-GTEKRCPGNSNACKR 248
EY+F +E + + YKC C +L N H C +C C++ T CP + K
Sbjct: 32 EYQF-VERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIK- 89
Query: 249 VXXXXXXXXXXXXXXXEKISKLIVNCP-IENCLFKDEVSKIDSHIRVCIFQQIYCPYQNI 425
++ L V C C K + + H++ C+FQ + C N
Sbjct: 90 -----SQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQC--SNE 142
Query: 426 GCRQIDLLKNEMTNHL 473
CR+ +L+ ++ HL
Sbjct: 143 KCRE-PVLRKDLKEHL 157
Score = 33.1 bits (74), Expect = 0.78
Identities = 20/65 (30%), Positives = 32/65 (49%)
Frame = +3
Query: 318 VNCPIENCLFKDEVSKIDSHIRVCIFQQIYCPYQNIGCRQIDLLKNEMTNHLLINIVPHS 497
V CP NC +++D H+ VC + CP+++ GC D +N + H + H
Sbjct: 193 VFCP-NNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRN-LQQHEHSALREHM 250
Query: 498 NLLLE 512
L+LE
Sbjct: 251 RLVLE 255
>sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6
Length = 530
Score = 51.2 bits (121), Expect = 3e-06
Identities = 32/125 (25%), Positives = 51/125 (40%), Gaps = 1/125 (0%)
Frame = +3
Query: 42 MSENFERLLKEYKFEIEN-INDDYKCVICKEILINAHSGPCHCNYCYDCLIKFLHGTEKR 218
+S +F ++ Y E + + Y+C IC L A PC +C C+IK + +
Sbjct: 45 LSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHK 104
Query: 219 CPGNSNACKRVXXXXXXXXXXXXXXXEKISKLIVNCPIENCLFKDEVSKIDSHIRVCIFQ 398
CP ++ +I L V CP + CL K E+ ++ H C F
Sbjct: 105 CPVDNE------ILLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFA 158
Query: 399 QIYCP 413
+ CP
Sbjct: 159 LVNCP 163
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 47.4 bits (111), Expect = 4e-05
Identities = 33/136 (24%), Positives = 55/136 (40%), Gaps = 2/136 (1%)
Frame = +3
Query: 72 EYKFEIENINDDYKCVICKEILINAHSGPCHCNYCYDCLIKFLH-GTEKRCPGNSNACKR 248
EY+F +E + + YKC C +L N H C +C C+ + CP + K
Sbjct: 32 EYQF-VEQLEERYKCAFCHSVLHNPHQTGCGHRFCQQCIRSLRELNSVPICPVDKEVIK- 89
Query: 249 VXXXXXXXXXXXXXXXEKISKLIVNCP-IENCLFKDEVSKIDSHIRVCIFQQIYCPYQNI 425
++ L V C C + + + H++ C FQ + CP N
Sbjct: 90 -----PQEVFKDNCCKREVLNLHVYCKNAPGCNARIILGRFQDHLQHCSFQAVPCP--NE 142
Query: 426 GCRQIDLLKNEMTNHL 473
CR+ +L+ ++ HL
Sbjct: 143 SCREA-MLRKDVKEHL 157
Score = 29.6 bits (65), Expect = 8.6
Identities = 16/61 (26%), Positives = 36/61 (59%), Gaps = 7/61 (11%)
Frame = +3
Query: 318 VNCPIENCLFKDEVSKIDSHIRVCIFQQIYCPYQNIGC----RQIDLLKNE---MTNHLL 476
V+CP C+ ++++ H+ VC + CP+++ GC ++ +LL++E + +H+L
Sbjct: 193 VSCP-NRCVQTIPRARVNEHLTVCPEAEQDCPFKHYGCTVKGKRGNLLEHERAALQDHML 251
Query: 477 I 479
+
Sbjct: 252 L 252
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 38.1 bits (87), Expect = 0.024
Identities = 29/134 (21%), Positives = 49/134 (36%), Gaps = 1/134 (0%)
Frame = +3
Query: 87 IENINDDYKCVICKEILINAHSGPCHCNYCYDCLIKFLHGTEKRCPGNSNACKRVXXXXX 266
++ + D YKC C+ +L N C +C C+ L + +C AC
Sbjct: 43 VKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKC----TAC-------- 90
Query: 267 XXXXXXXXXXEKISKLIVNCPIENCLFKDEVSKIDSHIRVCIFQQIYCPYQNIGC-RQID 443
+ + KD+V K + R + Q+YC + GC Q+
Sbjct: 91 ----------------------QESIIKDKVFKDNCCKREILALQVYCRNEGRGCAEQLT 128
Query: 444 LLKNEMTNHLLINI 485
L HLL+++
Sbjct: 129 L------GHLLVHL 136
Score = 29.6 bits (65), Expect = 8.6
Identities = 17/76 (22%), Positives = 36/76 (47%)
Frame = +3
Query: 312 LIVNCPIENCLFKDEVSKIDSHIRVCIFQQIYCPYQNIGCRQIDLLKNEMTNHLLINIVP 491
++V+CP + + S++ +H+ C+ C ++ GC ++ H + V
Sbjct: 199 VVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGC-VFQGTNQQIKAHEASSAVQ 257
Query: 492 HSNLLLEFLENIKNDV 539
H NLL E+ +++ V
Sbjct: 258 HVNLLKEWSNSLEKKV 273
>sp|O70263|LNX1_MOUSE Ubiquitin ligase LNX (Numb-binding protein 1) (Ligand of
Numb-binding protein 1) (Ligand of Numb-protein X 1)
Length = 728
Score = 37.4 bits (85), Expect = 0.041
Identities = 27/86 (31%), Positives = 38/86 (44%), Gaps = 2/86 (2%)
Frame = +3
Query: 90 ENINDDYKCVICKEILINAHSGPCHCNYCYDCLIKFLHGTEKR-CPGNSNACKRVXXXXX 266
E+++DD C IC + L++ PC YC CL FL EK CP R
Sbjct: 37 EDVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFL--VEKDFCP-----VDRKPVVLQ 89
Query: 267 XXXXXXXXXXEKISKLIVNCPI-ENC 341
+ ++KL+V CP E+C
Sbjct: 90 HCKKSSILVNKLLNKLLVTCPFTEHC 115
>sp|Q8TBB1|LNX1_HUMAN Ubiquitin ligase LNX (Numb-binding protein 1) (Ligand of
Numb-protein X 1)
Length = 728
Score = 37.0 bits (84), Expect = 0.054
Identities = 27/86 (31%), Positives = 37/86 (43%), Gaps = 2/86 (2%)
Frame = +3
Query: 90 ENINDDYKCVICKEILINAHSGPCHCNYCYDCLIKFLHGTEKR-CPGNSNACKRVXXXXX 266
E ++DD C IC + L++ PC YC CL FL EK CP R
Sbjct: 33 EEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFL--VEKDFCP-----MDRKPLVLQ 85
Query: 267 XXXXXXXXXXEKISKLIVNCPI-ENC 341
+ ++KL+V CP E+C
Sbjct: 86 HCKKSSILVNKLLNKLLVTCPFREHC 111
>sp|Q8N448|LNX2_HUMAN Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ
domain-containing RING finger protein 1)
Length = 690
Score = 37.0 bits (84), Expect = 0.054
Identities = 27/99 (27%), Positives = 42/99 (42%)
Frame = +3
Query: 75 YKFEIENINDDYKCVICKEILINAHSGPCHCNYCYDCLIKFLHGTEKRCPGNSNACKRVX 254
Y ++ E ++DD C IC + L+ PC +CY CL FL + CP R
Sbjct: 38 YNYQNE-VDDDLVCHICLQPLLQPLDTPCGHTFCYKCLRNFLQ-EKDFCP-----LDRKR 90
Query: 255 XXXXXXXXXXXXXXEKISKLIVNCPIENCLFKDEVSKID 371
+ + KL+V CP + + KD + + D
Sbjct: 91 LHFKLCKKSSILVHKLLDKLLVLCPFSS-VCKDVMQRCD 128
>sp|Q96PU4|UHRF2_HUMAN Ubiquitin-like containing PHD and RING finger domains protein 2
(Np95/ICBP90-like RING finger protein) (Np95-like RING
finger protein) (Nuclear zinc finger protein Np97) (RING
finger protein 107)
Length = 802
Score = 36.6 bits (83), Expect = 0.071
Identities = 18/65 (27%), Positives = 30/65 (46%)
Frame = +3
Query: 30 NKKLMSENFERLLKEYKFEIENINDDYKCVICKEILINAHSGPCHCNYCYDCLIKFLHGT 209
N+KL E L++ F ++ + + CV C+E++ + C N C DCL +
Sbjct: 706 NQKLWDEVLSHLVEGPNF-LKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQ 764
Query: 210 EKRCP 224
CP
Sbjct: 765 VFSCP 769
>sp|Q9BRZ2|TRI56_HUMAN Tripartite motif protein 56 (RING finger protein 109)
Length = 755
Score = 36.6 bits (83), Expect = 0.071
Identities = 18/47 (38%), Positives = 24/47 (51%), Gaps = 1/47 (2%)
Frame = +3
Query: 87 IENINDDY-KCVICKEILINAHSGPCHCNYCYDCLIKFLHGTEKRCP 224
+E ++ D+ C IC E L + PC YC DCL + G RCP
Sbjct: 11 LEALSSDFLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCP 57
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,475,336
Number of Sequences: 369166
Number of extensions: 1047832
Number of successful extensions: 3782
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3645
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3775
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6534486000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)