Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_010_E22
(857 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P35465|PAK1_RAT Serine/threonine-protein kinase PAK 1 (p... 246 8e-65
sp|O88643|PAK1_MOUSE Serine/threonine-protein kinase PAK 1 ... 245 1e-64
sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 ... 244 2e-64
sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p... 241 2e-63
sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 ... 241 2e-63
sp|Q61036|PAK3_MOUSE Serine/threonine-protein kinase PAK 3 ... 241 2e-63
sp|Q13177|PAK2_HUMAN Serine/threonine-protein kinase PAK 2 ... 236 8e-62
sp|Q29502|PAK2_RABIT Serine/threonine-protein kinase PAK 2 ... 236 8e-62
sp|Q64303|PAK2_RAT Serine/threonine-protein kinase PAK 2 (p... 235 1e-61
sp|Q8CIN4|PAK2_MOUSE Serine/threonine-protein kinase PAK 2 ... 235 1e-61
>sp|P35465|PAK1_RAT Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2)
Length = 544
Score = 246 bits (627), Expect = 8e-65
Identities = 122/208 (58%), Positives = 150/208 (72%), Gaps = 2/208 (0%)
Frame = +1
Query: 34 ELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALHFLHDKNIIHRDIKSDNVLLG 213
ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL FLH +IHRDIKSDN+LLG
Sbjct: 338 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLG 397
Query: 214 KSGQVKVTDFGFCAQLSSRSSRRQTMVGTPYWMAPEVVNRAVQYDEKIDIWSLGIMIIEM 393
G VK+TDFGFCAQ++ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM
Sbjct: 398 MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEM 456
Query: 394 LDGEPPYMDEAPLKAIYNIQTKGRPSPK--AKVDGDLENFLHACLEVDPSERKSAEALLK 567
++GEPPY++E PL+A+Y I T G P + K+ +FL+ CLE+D +R SA+ LL+
Sbjct: 457 IEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 516
Query: 568 HDFLKQCKSLKTIAASIEAAKKNLNKKH 651
H FLK K L ++ I AAK+ H
Sbjct: 517 HQFLKIAKPLSSLTPLIAAAKEATKNNH 544
>sp|O88643|PAK1_MOUSE Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase
PAK-A)
Length = 545
Score = 245 bits (625), Expect = 1e-64
Identities = 121/208 (58%), Positives = 149/208 (71%), Gaps = 2/208 (0%)
Frame = +1
Query: 34 ELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALHFLHDKNIIHRDIKSDNVLLG 213
ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL FLH +IHRDIKSDN+LLG
Sbjct: 339 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLG 398
Query: 214 KSGQVKVTDFGFCAQLSSRSSRRQTMVGTPYWMAPEVVNRAVQYDEKIDIWSLGIMIIEM 393
G VK+TDFGFCAQ++ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM
Sbjct: 399 MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEM 457
Query: 394 LDGEPPYMDEAPLKAIYNIQTKGRPSPK--AKVDGDLENFLHACLEVDPSERKSAEALLK 567
++GEPPY++E PL+A+Y I T G P + K+ +FL CLE+D +R SA+ LL+
Sbjct: 458 IEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLQCCLEMDVEKRGSAKELLQ 517
Query: 568 HDFLKQCKSLKTIAASIEAAKKNLNKKH 651
H FLK K L ++ + AAK+ H
Sbjct: 518 HQFLKIAKPLSSLTPLMHAAKEATKNNH 545
>sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P65-PAK) (Alpha-PAK)
Length = 545
Score = 244 bits (624), Expect = 2e-64
Identities = 121/208 (58%), Positives = 150/208 (72%), Gaps = 2/208 (0%)
Frame = +1
Query: 34 ELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALHFLHDKNIIHRDIKSDNVLLG 213
ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL FLH +IHRDIKSDN+LLG
Sbjct: 339 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLG 398
Query: 214 KSGQVKVTDFGFCAQLSSRSSRRQTMVGTPYWMAPEVVNRAVQYDEKIDIWSLGIMIIEM 393
G VK+TDFGFCAQ++ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM
Sbjct: 399 MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEM 457
Query: 394 LDGEPPYMDEAPLKAIYNIQTKGRPSPK--AKVDGDLENFLHACLEVDPSERKSAEALLK 567
++GEPPY++E PL+A+Y I T G P + K+ +FL+ CL++D +R SA+ LL+
Sbjct: 458 IEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLDMDVEKRGSAKELLQ 517
Query: 568 HDFLKQCKSLKTIAASIEAAKKNLNKKH 651
H FLK K L ++ I AAK+ H
Sbjct: 518 HQFLKIAKPLSSLTPLIAAAKEATKNNH 545
>sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (p65-PAK)
Length = 544
Score = 241 bits (614), Expect = 2e-63
Identities = 120/202 (59%), Positives = 148/202 (73%), Gaps = 2/202 (0%)
Frame = +1
Query: 34 ELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALHFLHDKNIIHRDIKSDNVLLG 213
ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL FLH +IHRDIKSDN+LLG
Sbjct: 337 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLG 396
Query: 214 KSGQVKVTDFGFCAQLSSRSSRRQTMVGTPYWMAPEVVNRAVQYDEKIDIWSLGIMIIEM 393
G VK+TDFGFCAQ++ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM
Sbjct: 397 MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEM 455
Query: 394 LDGEPPYMDEAPLKAIYNIQTKGRPSPK--AKVDGDLENFLHACLEVDPSERKSAEALLK 567
++GEPPY++E PL+A+Y I T G P + ++ +FL+ CLE+D R SA+ LL+
Sbjct: 456 VEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 515
Query: 568 HDFLKQCKSLKTIAASIEAAKK 633
H FLK K L ++ I AAK+
Sbjct: 516 HPFLKLAKPLSSLTPLILAAKE 537
>sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (Oligophrenin-3)
sp|Q7YQL3|PAK3_PONPY Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3)
sp|Q7YQL4|PAK3_PANTR Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3)
Length = 559
Score = 241 bits (614), Expect = 2e-63
Identities = 120/202 (59%), Positives = 148/202 (73%), Gaps = 2/202 (0%)
Frame = +1
Query: 34 ELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALHFLHDKNIIHRDIKSDNVLLG 213
ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL FLH +IHRDIKSDN+LLG
Sbjct: 352 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLG 411
Query: 214 KSGQVKVTDFGFCAQLSSRSSRRQTMVGTPYWMAPEVVNRAVQYDEKIDIWSLGIMIIEM 393
G VK+TDFGFCAQ++ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM
Sbjct: 412 MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEM 470
Query: 394 LDGEPPYMDEAPLKAIYNIQTKGRPSPK--AKVDGDLENFLHACLEVDPSERKSAEALLK 567
++GEPPY++E PL+A+Y I T G P + ++ +FL+ CLE+D R SA+ LL+
Sbjct: 471 VEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Query: 568 HDFLKQCKSLKTIAASIEAAKK 633
H FLK K L ++ I AAK+
Sbjct: 531 HPFLKLAKPLSSLTPLIIAAKE 552
>sp|Q61036|PAK3_MOUSE Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B)
Length = 559
Score = 241 bits (614), Expect = 2e-63
Identities = 120/202 (59%), Positives = 148/202 (73%), Gaps = 2/202 (0%)
Frame = +1
Query: 34 ELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALHFLHDKNIIHRDIKSDNVLLG 213
ELWVV+EYL GG+LTDVVTET MD G IA+V +ECL AL FLH +IHRDIKSDN+LLG
Sbjct: 352 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLG 411
Query: 214 KSGQVKVTDFGFCAQLSSRSSRRQTMVGTPYWMAPEVVNRAVQYDEKIDIWSLGIMIIEM 393
G VK+TDFGFCAQ++ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM
Sbjct: 412 MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEM 470
Query: 394 LDGEPPYMDEAPLKAIYNIQTKGRPSPK--AKVDGDLENFLHACLEVDPSERKSAEALLK 567
++GEPPY++E PL+A+Y I T G P + ++ +FL+ CLE+D R SA+ LL+
Sbjct: 471 VEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Query: 568 HDFLKQCKSLKTIAASIEAAKK 633
H FLK K L ++ I AAK+
Sbjct: 531 HPFLKLAKPLSSLTPLIIAAKE 552
>sp|Q13177|PAK2_HUMAN Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase)
Length = 524
Score = 236 bits (601), Expect = 8e-62
Identities = 120/202 (59%), Positives = 148/202 (73%), Gaps = 2/202 (0%)
Frame = +1
Query: 34 ELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALHFLHDKNIIHRDIKSDNVLLG 213
EL+VV+EYL GG+LTDVVTET MD IA+V +ECL AL FLH +IHRDIKSDNVLLG
Sbjct: 318 ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLG 377
Query: 214 KSGQVKVTDFGFCAQLSSRSSRRQTMVGTPYWMAPEVVNRAVQYDEKIDIWSLGIMIIEM 393
G VK+TDFGFCAQ++ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM
Sbjct: 378 MEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEM 436
Query: 394 LDGEPPYMDEAPLKAIYNIQTKGRPSPK--AKVDGDLENFLHACLEVDPSERKSAEALLK 567
++GEPPY++E PL+A+Y I T G P + K+ +FL+ CLE+D +R SA+ LL+
Sbjct: 437 VEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQ 496
Query: 568 HDFLKQCKSLKTIAASIEAAKK 633
H FLK K L ++ I AAK+
Sbjct: 497 HPFLKLAKPLSSLTPLIMAAKE 518
>sp|Q29502|PAK2_RABIT Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2) (Gamma-PAK) (p21-activated protein kinase I)
(PAKI)
Length = 524
Score = 236 bits (601), Expect = 8e-62
Identities = 120/202 (59%), Positives = 148/202 (73%), Gaps = 2/202 (0%)
Frame = +1
Query: 34 ELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALHFLHDKNIIHRDIKSDNVLLG 213
EL+VV+EYL GG+LTDVVTET MD IA+V +ECL AL FLH +IHRDIKSDNVLLG
Sbjct: 318 ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLG 377
Query: 214 KSGQVKVTDFGFCAQLSSRSSRRQTMVGTPYWMAPEVVNRAVQYDEKIDIWSLGIMIIEM 393
G VK+TDFGFCAQ++ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM
Sbjct: 378 MEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEM 436
Query: 394 LDGEPPYMDEAPLKAIYNIQTKGRPSPK--AKVDGDLENFLHACLEVDPSERKSAEALLK 567
++GEPPY++E PL+A+Y I T G P + K+ +FL+ CLE+D +R SA+ LL+
Sbjct: 437 VEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQ 496
Query: 568 HDFLKQCKSLKTIAASIEAAKK 633
H FLK K L ++ I AAK+
Sbjct: 497 HPFLKLAKPLSSLTPLIMAAKE 518
>sp|Q64303|PAK2_RAT Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2) (Gamma-PAK) (p62-PAK)
Length = 524
Score = 235 bits (600), Expect = 1e-61
Identities = 120/202 (59%), Positives = 148/202 (73%), Gaps = 2/202 (0%)
Frame = +1
Query: 34 ELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALHFLHDKNIIHRDIKSDNVLLG 213
EL+VV+EYL GG+LTDVVTET MD IA+V +ECL AL FLH +IHRDIKSDNVLLG
Sbjct: 318 ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLG 377
Query: 214 KSGQVKVTDFGFCAQLSSRSSRRQTMVGTPYWMAPEVVNRAVQYDEKIDIWSLGIMIIEM 393
G VK+TDFGFCAQ++ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM
Sbjct: 378 MEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEM 436
Query: 394 LDGEPPYMDEAPLKAIYNIQTKGRPSPK--AKVDGDLENFLHACLEVDPSERKSAEALLK 567
++GEPPY++E PL+A+Y I T G P + K+ +FL+ CLE+D +R SA+ LL+
Sbjct: 437 VEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQ 496
Query: 568 HDFLKQCKSLKTIAASIEAAKK 633
H FLK K L ++ I AAK+
Sbjct: 497 HPFLKLAKPLSSLTPLILAAKE 518
>sp|Q8CIN4|PAK2_MOUSE Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2)
Length = 524
Score = 235 bits (600), Expect = 1e-61
Identities = 120/202 (59%), Positives = 148/202 (73%), Gaps = 2/202 (0%)
Frame = +1
Query: 34 ELWVVIEYLDGGALTDVVTETIMDNGLIASVVKECLNALHFLHDKNIIHRDIKSDNVLLG 213
EL+VV+EYL GG+LTDVVTET MD IA+V +ECL AL FLH +IHRDIKSDNVLLG
Sbjct: 318 ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLG 377
Query: 214 KSGQVKVTDFGFCAQLSSRSSRRQTMVGTPYWMAPEVVNRAVQYDEKIDIWSLGIMIIEM 393
G VK+TDFGFCAQ++ S+R TMVGTPYWMAPEVV R Y K+DIWSLGIM IEM
Sbjct: 378 MEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEM 436
Query: 394 LDGEPPYMDEAPLKAIYNIQTKGRPSPK--AKVDGDLENFLHACLEVDPSERKSAEALLK 567
++GEPPY++E PL+A+Y I T G P + K+ +FL+ CLE+D +R SA+ LL+
Sbjct: 437 VEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQ 496
Query: 568 HDFLKQCKSLKTIAASIEAAKK 633
H FLK K L ++ I AAK+
Sbjct: 497 HPFLKLAKPLSSLTPLILAAKE 518
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,803,649
Number of Sequences: 369166
Number of extensions: 1781000
Number of successful extensions: 9075
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6652
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7055
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8486520240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)