Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_010_E03
(822 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9H845|ACAD9_HUMAN Acyl-CoA dehydrogenase family member ... 88 3e-17
sp|Q8JZN5|ACAD9_MOUSE Acyl-CoA dehydrogenase family member ... 78 3e-14
sp|Q8HXY7|ACADV_MACFA Acyl-CoA dehydrogenase, very-long-cha... 74 5e-13
sp|P49748|ACADV_HUMAN Acyl-CoA dehydrogenase, very-long-cha... 73 1e-12
sp|P48818|ACADV_BOVIN Acyl-CoA dehydrogenase, very-long-cha... 68 3e-11
sp|P12007|IVD_RAT Isovaleryl-CoA dehydrogenase, mitochondri... 58 3e-08
sp|Q5RBD5|IVD_PONPY Isovaleryl-CoA dehydrogenase, mitochond... 58 4e-08
sp|Q9JHI5|IVD_MOUSE Isovaleryl-CoA dehydrogenase, mitochond... 57 5e-08
sp|P26440|IVD_HUMAN Isovaleryl-CoA dehydrogenase, mitochond... 57 5e-08
sp|P45952|ACADM_MOUSE Acyl-CoA dehydrogenase, medium-chain ... 54 7e-07
>sp|Q9H845|ACAD9_HUMAN Acyl-CoA dehydrogenase family member 9, mitochondrial precursor
(ACAD-9)
Length = 621
Score = 87.8 bits (216), Expect = 3e-17
Identities = 69/267 (25%), Positives = 126/267 (47%), Gaps = 14/267 (5%)
Frame = +3
Query: 6 IFGLCLPELYDGHRFNNMMLAKVVEVMANDMRYLFNTFIPRNLGSQALFLAGTEEQKAGY 185
+FGL +PE Y G F+N M +++ E+++ D + +G + + LAGTEEQKA Y
Sbjct: 106 LFGLQVPEEYGGLGFSNTMYSRLGEIISMDGSITVTLAAHQAIGLKGIILAGTEEQKAKY 165
Query: 186 LKKLTVGQIKATVAVHE--SNNDFINLENINTSVFHDKESNMYVIDGKKTLVKGLYDCDY 359
L KL G+ A + E S +D ++ + ++ DK+ Y+++G K + +
Sbjct: 166 LPKLASGEHIAAFCLTEPASGSDAASIRS-RATLSEDKKH--YILNGSKVWITNGGLANI 222
Query: 360 VIVFAKT--------VENEVRPFLVDLKSEGIKIQPYYFHENNPLNV---STCSLELNKV 506
VFAKT V++++ F+V+ G+ + L + +TC +
Sbjct: 223 FTVFAKTEVVDSDGSVKDKITAFIVERDFGGVT----NGKPEDKLGIRGSNTCEVHFENT 278
Query: 507 QVPANNIMNSDSKN-KTIKHLAAIENCTVAAACSGLIRELLRKANEFAYNQAIFGKPLIK 683
++P NI+ K ++ ++ + +GL++ L+ E+A + F K L +
Sbjct: 279 KIPVENILGEVGDGFKVAMNILNSGRFSMGSVVAGLLKRLIEMTAEYACTRKQFNKRLSE 338
Query: 684 FEKMQYYFLKFTDEAYSAESVAFQVAG 764
F +Q F +AY ES+ + AG
Sbjct: 339 FGLIQEKFALMAQKAYVMESMTYLTAG 365
>sp|Q8JZN5|ACAD9_MOUSE Acyl-CoA dehydrogenase family member 9, mitochondrial precursor
(ACAD-9)
Length = 625
Score = 77.8 bits (190), Expect = 3e-14
Identities = 61/265 (23%), Positives = 121/265 (45%), Gaps = 12/265 (4%)
Frame = +3
Query: 6 IFGLCLPELYDGHRFNNMMLAKVVEVMANDMRYLFNTFIPRNLGSQALFLAGTEEQKAGY 185
+FG+ +PE Y G +N M A++ E+++ D + +G + + L G +EQKA Y
Sbjct: 110 LFGIQVPEEYGGLGLSNTMYARLGEIISLDASITVTLAAHQAIGLKGIILVGNDEQKAKY 169
Query: 186 LKKLTVGQIKATVAVHESNNDFINLENINTSVFHDKESNMYVIDGKKTLVKGLYDCDYVI 365
L KL+ G+ A + E + + +I T ++ ++++G K + +
Sbjct: 170 LPKLSSGEHIAAFCLTEPASG-SDAASIQTRATLSEDKKYFILNGSKVWITNGGLANIFT 228
Query: 366 VFAKT--------VENEVRPFLVDLKSEGIKIQPYYFHENNPLNV---STCSLELNKVQV 512
VFAKT +++ F+V+ GI + L + +TC + +V
Sbjct: 229 VFAKTEVVDSDGSKTDKMTAFIVERDFGGIT----NGKPEDKLGIRGSNTCEVHFENTRV 284
Query: 513 PANNIMNSDSKN-KTIKHLAAIENCTVAAACSGLIRELLRKANEFAYNQAIFGKPLIKFE 689
P N++ K ++ ++ +A +G++++L+ E+A + F + L +F
Sbjct: 285 PVENVLGEVGGGFKVAMNILNSGRFSMGSAVAGMLKKLIELTAEYACTRKQFNRNLSEFG 344
Query: 690 KMQYYFLKFTDEAYSAESVAFQVAG 764
+Q F +AY ES+A+ +G
Sbjct: 345 LIQEKFALMAQKAYVMESMAYLTSG 369
>sp|Q8HXY7|ACADV_MACFA Acyl-CoA dehydrogenase, very-long-chain specific, mitochondrial
precursor (VLCAD)
Length = 655
Score = 73.9 bits (180), Expect = 5e-13
Identities = 67/263 (25%), Positives = 119/263 (45%), Gaps = 12/263 (4%)
Frame = +3
Query: 9 FGLCLPELYDGHRFNNMMLAKVVEVMA-NDMRYLFNTFIPRNLGSQALFLAGTEEQKAGY 185
FGL +P G N A++VE++ +D+ +++G + + L GT+ QK Y
Sbjct: 142 FGLQVPSELGGVGLCNTQYARLVEIVGMHDLAVGITLGAHQSIGFKGILLFGTKAQKEKY 201
Query: 186 LKKLTVGQIKATVAVHESNNDFINLENINTSVFHDKESNMYVIDGKKTLVKGLYDCDYVI 365
L KL G+ A + E ++ + +I TS Y ++G K + D
Sbjct: 202 LPKLASGETLAAFCLTEPSSGS-DAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFT 260
Query: 366 VFAKT---------VENEVRPFLVDLKSEGIKIQPYYFHENNPLNVS-TCSLELNKVQVP 515
VFAKT V+ ++ F+V+ G+ P + + S T + + V+VP
Sbjct: 261 VFAKTPVTDPATGAVKEKITAFVVERGFGGVTHGPP--EKKMGIKASNTAEVLFDGVRVP 318
Query: 516 ANNIMNS-DSKNKTIKHLAAIENCTVAAACSGLIRELLRKANEFAYNQAIFGKPLIKFEK 692
+ N++ S K H+ +AAA +G +R ++ KA ++A N+ FG+ + F
Sbjct: 319 SENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIITKAVDYATNRIQFGEKIHNFGL 378
Query: 693 MQYYFLKFTDEAYSAESVAFQVA 761
+Q + Y ES+A+ V+
Sbjct: 379 IQEKLARMVMLQYVTESMAYMVS 401
>sp|P49748|ACADV_HUMAN Acyl-CoA dehydrogenase, very-long-chain specific, mitochondrial
precursor (VLCAD)
Length = 655
Score = 72.8 bits (177), Expect = 1e-12
Identities = 68/263 (25%), Positives = 118/263 (44%), Gaps = 12/263 (4%)
Frame = +3
Query: 9 FGLCLPELYDGHRFNNMMLAKVVEVMA-NDMRYLFNTFIPRNLGSQALFLAGTEEQKAGY 185
FGL +P G N A++VE++ +D+ +++G + + L GT+ QK Y
Sbjct: 142 FGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKY 201
Query: 186 LKKLTVGQIKATVAVHESNNDFINLENINTSVFHDKESNMYVIDGKKTLVKGLYDCDYVI 365
L KL G+ A + E ++ + +I TS Y ++G K + D
Sbjct: 202 LPKLASGETVAAFCLTEPSSGS-DAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFT 260
Query: 366 VFAKT---------VENEVRPFLVDLKSEGIKIQPYYFHENNPLNVS-TCSLELNKVQVP 515
VFAKT V+ ++ F+V+ GI P + + S T + + V+VP
Sbjct: 261 VFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPP--EKKMGIKASNTAEVFFDGVRVP 318
Query: 516 ANNIMNS-DSKNKTIKHLAAIENCTVAAACSGLIRELLRKANEFAYNQAIFGKPLIKFEK 692
+ N++ S K H+ +AAA +G +R ++ KA + A N+ FG+ + F
Sbjct: 319 SENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQFGEKIHNFGL 378
Query: 693 MQYYFLKFTDEAYSAESVAFQVA 761
+Q + Y ES+A+ V+
Sbjct: 379 IQEKLARMVMLQYVTESMAYMVS 401
>sp|P48818|ACADV_BOVIN Acyl-CoA dehydrogenase, very-long-chain specific, mitochondrial
precursor (VLCAD)
Length = 655
Score = 68.2 bits (165), Expect = 3e-11
Identities = 65/263 (24%), Positives = 116/263 (44%), Gaps = 12/263 (4%)
Frame = +3
Query: 9 FGLCLPELYDGHRFNNMMLAKVVEVMAN-DMRYLFNTFIPRNLGSQALFLAGTEEQKAGY 185
FGL +P G N A++VE++ D+ +++G + + L GT+ QK Y
Sbjct: 142 FGLQVPNELGGVGLCNTQYARLVEIVGMYDLGVGIVLGAHQSIGFKGILLFGTKAQKEKY 201
Query: 186 LKKLTVGQIKATVAVHESNNDFINLENINTSVFHDKESNMYVIDGKKTLVKGLYDCDYVI 365
L KL G+ A + E ++ + +I +S Y ++G K + D
Sbjct: 202 LPKLASGETIAAFCLTEPSSGS-DAASIRSSAVPSPCGKYYTLNGSKIWISNGGLADIFT 260
Query: 366 VFAKT---------VENEVRPFLVDLKSEGIKIQPYYFHENNPLNVS-TCSLELNKVQVP 515
VFAKT V+ ++ F+V+ G+ P + + S T + + V+VP
Sbjct: 261 VFAKTPVTDTATGAVKEKITAFVVERSFGGVTHGPP--EKKMGIKASNTAEVYFDGVRVP 318
Query: 516 ANNIMNSDSKN-KTIKHLAAIENCTVAAACSGLIRELLRKANEFAYNQAIFGKPLIKFEK 692
A N++ K H+ +AAA +G ++ ++ KA + A N+ FG+ + F
Sbjct: 319 AENVLGEVGGGFKVAMHILNNGRFGMAAALAGTMKGIIAKAVDHAANRTQFGEKIHNFGL 378
Query: 693 MQYYFLKFTDEAYSAESVAFQVA 761
+Q + Y ES+A+ V+
Sbjct: 379 IQEKLARMAMLQYVTESMAYMVS 401
>sp|P12007|IVD_RAT Isovaleryl-CoA dehydrogenase, mitochondrial precursor (IVD)
Length = 424
Score = 58.2 bits (139), Expect = 3e-08
Identities = 53/239 (22%), Positives = 102/239 (42%), Gaps = 8/239 (3%)
Frame = +3
Query: 6 IFGLCLPELYDGHRFNNMMLAKVVEVMANDMRYLFNTF-IPRNLGSQALFLAGTEEQKAG 182
+ G+ P Y G + V+E ++ + ++ NL + G E QK
Sbjct: 90 VLGITAPVQYGGSGLGYLEHVLVMEEISRASAAVGLSYGAHSNLCINQIVRNGNEAQKEK 149
Query: 183 YLKKLTVGQIKATVAVHESNNDFINLENINTSVFHDKESNMYVIDGKKTLVKGLYDCDYV 362
YL KL G+ +A+ E N + ++ + +K+ + YV++G K + D D +
Sbjct: 150 YLPKLISGEFIGALAMSEPN---AGSDVVSMRLKAEKKGDHYVLNGNKFWITNGPDADVL 206
Query: 363 IVFAKT------VENEVRPFLVDLKSEGIKIQPYYFHENNPLNVSTCSLELNKVQVPANN 524
+V+AKT + F+V+ G + +TC L +VPA N
Sbjct: 207 VVYAKTDLTAVPASRGITAFIVEKDMPGFSTSK-KLDKLGMRGSNTCELVFEDCKVPAAN 265
Query: 525 IMNSDSKNKTIKHLAA-IENCTVAAACSGLIRELLRKANEFAYNQAIFGKPLIKFEKMQ 698
I++ +SK + +E +A G+++ +L + + + FG+ + +F+ MQ
Sbjct: 266 ILSQESKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQ 324
>sp|Q5RBD5|IVD_PONPY Isovaleryl-CoA dehydrogenase, mitochondrial precursor (IVD)
Length = 423
Score = 57.8 bits (138), Expect = 4e-08
Identities = 49/197 (24%), Positives = 85/197 (43%), Gaps = 7/197 (3%)
Frame = +3
Query: 129 NLGSQALFLAGTEEQKAGYLKKLTVGQIKATVAVHESNNDFINLENINTSVFHDKESNMY 308
NL L G E QK YL KL G+ +A+ E N + ++ + +K+ N Y
Sbjct: 131 NLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPN---AGSDVVSMKLKAEKKGNHY 187
Query: 309 VIDGKKTLVKGLYDCDYVIVFAKT------VENEVRPFLVDLKSEGIKIQPYYFHENNPL 470
+++G K + D D +IV+AKT + F+V+ G +
Sbjct: 188 ILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSK-KLDKLGMR 246
Query: 471 NVSTCSLELNKVQVPANNIMNSDSKNKTIKHLAA-IENCTVAAACSGLIRELLRKANEFA 647
+TC L +VPA NI+ ++K + +E +A GL++ +L +
Sbjct: 247 GSNTCELIFEDCKVPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYL 306
Query: 648 YNQAIFGKPLIKFEKMQ 698
+ + FG+ + F+ MQ
Sbjct: 307 HVREAFGQKIGHFQLMQ 323
>sp|Q9JHI5|IVD_MOUSE Isovaleryl-CoA dehydrogenase, mitochondrial precursor (IVD)
Length = 424
Score = 57.4 bits (137), Expect = 5e-08
Identities = 46/197 (23%), Positives = 87/197 (44%), Gaps = 7/197 (3%)
Frame = +3
Query: 129 NLGSQALFLAGTEEQKAGYLKKLTVGQIKATVAVHESNNDFINLENINTSVFHDKESNMY 308
NL + G E QK YL KL G+ +A+ E N + ++ + +K+ + Y
Sbjct: 132 NLCVNQIVRNGNEAQKEKYLPKLISGEFIGALAMSEPN---AGSDVVSMKLKAEKKGDHY 188
Query: 309 VIDGKKTLVKGLYDCDYVIVFAKT------VENEVRPFLVDLKSEGIKIQPYYFHENNPL 470
V++G K + D D ++V+AKT + F+V+ G +
Sbjct: 189 VLNGNKFWITNGPDADILVVYAKTDLTAVPASRGITAFIVEKGMPGFSTSK-KLDKLGMR 247
Query: 471 NVSTCSLELNKVQVPANNIMNSDSKNKTIKHLAA-IENCTVAAACSGLIRELLRKANEFA 647
+TC L +VPA N+++ +SK + +E +A G+++ +L +
Sbjct: 248 GSNTCELVFEDCKVPAANVLSQESKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYL 307
Query: 648 YNQAIFGKPLIKFEKMQ 698
+ + FG+ + +F+ MQ
Sbjct: 308 HVREAFGQKIGQFQLMQ 324
>sp|P26440|IVD_HUMAN Isovaleryl-CoA dehydrogenase, mitochondrial precursor (IVD)
Length = 423
Score = 57.4 bits (137), Expect = 5e-08
Identities = 48/197 (24%), Positives = 85/197 (43%), Gaps = 7/197 (3%)
Frame = +3
Query: 129 NLGSQALFLAGTEEQKAGYLKKLTVGQIKATVAVHESNNDFINLENINTSVFHDKESNMY 308
NL L G E QK YL KL G+ +A+ E N + ++ + +K+ N Y
Sbjct: 131 NLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPN---AGSDVVSMKLKAEKKGNHY 187
Query: 309 VIDGKKTLVKGLYDCDYVIVFAKT------VENEVRPFLVDLKSEGIKIQPYYFHENNPL 470
+++G K + D D +IV+AKT + F+V+ G +
Sbjct: 188 ILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSK-KLDKLGMR 246
Query: 471 NVSTCSLELNKVQVPANNIMNSDSKNKTIKHLAA-IENCTVAAACSGLIRELLRKANEFA 647
+TC L ++PA NI+ ++K + +E +A GL++ +L +
Sbjct: 247 GSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYL 306
Query: 648 YNQAIFGKPLIKFEKMQ 698
+ + FG+ + F+ MQ
Sbjct: 307 HVREAFGQKIGHFQLMQ 323
>sp|P45952|ACADM_MOUSE Acyl-CoA dehydrogenase, medium-chain specific, mitochondrial
precursor (MCAD)
Length = 421
Score = 53.5 bits (127), Expect = 7e-07
Identities = 55/245 (22%), Positives = 104/245 (42%), Gaps = 12/245 (4%)
Frame = +3
Query: 3 WIFGLC---LPELYDGHRFNNMMLAKVVEVMANDMRYLFNTFIPRNLGSQALFLAGTEEQ 173
W GL +PE G + E +A + +LG + LAG ++Q
Sbjct: 82 WELGLINAHIPESCGGLGLGTFDACLITEELAYGCTGVQTAIEANSLGQMPVILAGNDQQ 141
Query: 174 KAGYLKKLTVGQIKATVAVHESNNDFINLENINTSVFHDKESNMYVIDGKKTLVKGLYDC 353
K YL ++T + V E + ++ I T +K+ + YVI+G+K +
Sbjct: 142 KKKYLGRMTEQPMMCAYCVTEPSAGS-DVAAIKTKA--EKKGDEYVINGQKMWITNGGKA 198
Query: 354 DYVIVFAKTVENEVRP-------FLVDLKSEGIKIQPYYFHENNPLNVSTCSLELNKVQV 512
++ + A++ + P F+V+ + GI I + + T + V+V
Sbjct: 199 NWYFLLARSNPDPKVPASKAFTGFIVEADTPGIHIGKKELNMGQRCS-DTRGIAFEDVRV 257
Query: 513 PANNIMNSDSKNKTIKHLAAIENC--TVAAACSGLIRELLRKANEFAYNQAIFGKPLIKF 686
P N++ + I + A + TVAA GL + L +A ++A ++ FGK L++
Sbjct: 258 PKENVLIGEGAGFKIA-MGAFDRTRPTVAAGAVGLAQRALDEATKYALDRKTFGKLLVEH 316
Query: 687 EKMQY 701
+ + +
Sbjct: 317 QGVSF 321
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,637,938
Number of Sequences: 369166
Number of extensions: 1626702
Number of successful extensions: 3969
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3851
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3949
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7907893860
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)