Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_010_C20
(600 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 169 4e-42
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 167 1e-41
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 151 1e-36
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 150 2e-36
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 150 2e-36
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 150 2e-36
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 150 2e-36
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 149 7e-36
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 148 1e-35
sp|O35186|CATK_RAT Cathepsin K precursor 147 3e-35
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 169 bits (429), Expect = 4e-42
Identities = 78/156 (50%), Positives = 109/156 (69%), Gaps = 2/156 (1%)
Frame = +1
Query: 1 SGCKGGSPDNSFNYYKPYG-MNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQ 177
+GC GG DN+F Y K G ++ E++YPY I D C +N +V A F D+ + +E +
Sbjct: 186 NGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKK 245
Query: 178 VAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESE-GEDYWI 354
+A AV+ GP++ IDAS SFQFY EG+YN+P C + +H VL+VG+G E GEDYW+
Sbjct: 246 MAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWL 305
Query: 355 VKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 462
VKNSWG WGD G+IKM+R+ NQCGIAS++S+P++
Sbjct: 306 VKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 167 bits (424), Expect = 1e-41
Identities = 76/154 (49%), Positives = 106/154 (68%), Gaps = 2/154 (1%)
Frame = +1
Query: 1 SGCKGGSPDNSFNYYKPYG-MNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQ 177
+GC GG DN+F Y K G ++ E++YPY GI D C +N ++ A F+D+ +E +
Sbjct: 184 NGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEK 243
Query: 178 VAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESE-GEDYWI 354
+ AV+ GP++ IDAS SFQ Y EG+YN+P C + + +H VL+VGYG E G DYW+
Sbjct: 244 MKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWL 303
Query: 355 VKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 456
VKNSWG WG+ GYIKM R+ NNQCGIA+++S+P
Sbjct: 304 VKNSWGTTWGEQGYIKMARNQNNQCGIATASSYP 337
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 151 bits (382), Expect = 1e-36
Identities = 67/154 (43%), Positives = 90/154 (58%)
Frame = +1
Query: 1 SGCKGGSPDNSFNYYKPYGMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQV 180
+GC GG +N++ Y K +G+ E +YPY ++ +C+YN +A V + V +E+++
Sbjct: 170 NGCSGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVEL 229
Query: 181 AAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESEGEDYWIVK 360
V A P +D F YR GIY TCS NHAVL VGYG G DYWIVK
Sbjct: 230 KNLVGARRPAAVAVDVE-SDFMMYRSGIYQSQTCSPLRVNHAVLAVGYGTQGGTDYWIVK 288
Query: 361 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 462
NSWG WG+ GYI+M R+ N CGIAS S P++
Sbjct: 289 NSWGTYWGERGYIRMARNRGNMCGIASLASLPMV 322
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 150 bits (380), Expect = 2e-36
Identities = 71/152 (46%), Positives = 96/152 (63%), Gaps = 1/152 (0%)
Frame = +1
Query: 4 GCKGGSPDNSFNYY-KPYGMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQV 180
GC GG N+F Y K G+++E+ YPY G ++ C YN A + ++ NE +
Sbjct: 176 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL 235
Query: 181 AAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESEGEDYWIVK 360
AV+ GP++ IDASL SFQFY +G+Y D +C+ + NHAVL VGYG +G +WI+K
Sbjct: 236 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIK 295
Query: 361 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 456
NSWG WG+ GYI M R+ NN CGIA+ SFP
Sbjct: 296 NSWGENWGNKGYILMARNKNNACGIANLASFP 327
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 150 bits (380), Expect = 2e-36
Identities = 71/152 (46%), Positives = 96/152 (63%), Gaps = 1/152 (0%)
Frame = +1
Query: 4 GCKGGSPDNSFNYY-KPYGMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQV 180
GC GG N+F Y K G+++E+ YPY G ++ C YN A + ++ NE +
Sbjct: 176 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL 235
Query: 181 AAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESEGEDYWIVK 360
AV+ GP++ IDASL SFQFY +G+Y D +C+ + NHAVL VGYG +G +WI+K
Sbjct: 236 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIK 295
Query: 361 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 456
NSWG WG+ GYI M R+ NN CGIA+ SFP
Sbjct: 296 NSWGENWGNKGYILMARNKNNACGIANLASFP 327
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 150 bits (379), Expect = 2e-36
Identities = 71/152 (46%), Positives = 94/152 (61%), Gaps = 1/152 (0%)
Frame = +1
Query: 4 GCKGGSPDNSFNYY-KPYGMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQV 180
GC GG N+F Y + G+++E+ YPY G + C YN A + ++ NE +
Sbjct: 176 GCGGGYMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKAL 235
Query: 181 AAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESEGEDYWIVK 360
AV+ GP++ IDASL SFQFY +G+Y D CS + NHAVL VGYG +G +WI+K
Sbjct: 236 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIK 295
Query: 361 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 456
NSWG WG+ GYI M R+ NN CGIA+ SFP
Sbjct: 296 NSWGESWGNKGYILMARNKNNACGIANLASFP 327
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 150 bits (379), Expect = 2e-36
Identities = 71/152 (46%), Positives = 95/152 (62%), Gaps = 1/152 (0%)
Frame = +1
Query: 4 GCKGGSPDNSFNYY-KPYGMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQV 180
GC GG N+F Y K G+++E+ YPY G + C YN A + ++ NE +
Sbjct: 177 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKAL 236
Query: 181 AAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESEGEDYWIVK 360
AV+ GP++ IDASL SFQFY +G+Y D C+ + NHAVL VGYG +G+ +WI+K
Sbjct: 237 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCNSDNLNHAVLAVGYGIQKGKKHWIIK 296
Query: 361 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 456
NSWG WG+ GYI M R+ NN CGIA+ SFP
Sbjct: 297 NSWGENWGNKGYILMARNKNNACGIANLASFP 328
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 149 bits (375), Expect = 7e-36
Identities = 69/154 (44%), Positives = 99/154 (64%), Gaps = 1/154 (0%)
Frame = +1
Query: 4 GCKGGSPDNSFNYYKPY-GMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQV 180
GC GG +++F+Y K G++ E YPY C++++NSV A ++A +E +
Sbjct: 170 GCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGL 229
Query: 181 AAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESEGEDYWIVK 360
AV GP++ IDA+ SFQFY G+Y +P+CS + +HAVL VGYG G+D+W+VK
Sbjct: 230 QQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVK 289
Query: 361 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 462
NSW WGD GYIKM R+ NN CGIA+ S+P++
Sbjct: 290 NSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 148 bits (373), Expect = 1e-35
Identities = 71/156 (45%), Positives = 98/156 (62%), Gaps = 5/156 (3%)
Frame = +1
Query: 4 GCKGGSPDNSFNYYKPYG-MNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQV 180
GC GG D +F Y + G +++EE+YPY ++ CKYN +A+ F+D+ + E +
Sbjct: 177 GCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKAL 235
Query: 181 AAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYG----ESEGEDY 348
AV+ GP++ IDA SF FY+EGIY +P CS +H VL+VGYG ES+ Y
Sbjct: 236 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY 295
Query: 349 WIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 456
W+VKNSWG WG GY+KM +D N CGIAS+ S+P
Sbjct: 296 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYP 331
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 147 bits (370), Expect = 3e-35
Identities = 67/152 (44%), Positives = 93/152 (61%), Gaps = 1/152 (0%)
Frame = +1
Query: 4 GCKGGSPDNSFNYYKPYG-MNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQV 180
GC GG +F Y + G +++E+ YPY G + C YN + A + ++ NE +
Sbjct: 176 GCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKAL 235
Query: 181 AAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESEGEDYWIVK 360
AV+ GP++ IDASL SFQFY G+Y D C + + NHAVL+VGYG +G YWI+K
Sbjct: 236 KRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIK 295
Query: 361 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 456
NSWG WG+ GY+ + R+ NN CGI + SFP
Sbjct: 296 NSWGESWGNKGYVLLARNKNNACGITNLASFP 327
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,277,531
Number of Sequences: 369166
Number of extensions: 929620
Number of successful extensions: 3028
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2696
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2763
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4602033670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)