Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= Dr_sW_010_C14 (793 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-... 346 4e-95 sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-... 337 3e-92 sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-... 335 1e-91 sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I)... 329 6e-90 sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-... 326 4e-89 sp|Q26563|CATC_SCHMA Cathepsin C precursor 295 1e-79 sp|P80884|ANAN_ANACO Ananain precursor 146 6e-35 sp|P00786|CATH_RAT Cathepsin H precursor (Cathepsin B3) (Ca... 135 1e-31 sp|Q90686|CATK_CHICK Cathepsin K precursor (JTAP-1) 130 4e-30 sp|O35186|CATK_RAT Cathepsin K precursor 130 5e-30
>sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C) (Cathepsin J) (Dipeptidyl transferase) [Contains: Dipeptidyl-peptidase I exclusion domain chain; Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase I light chain] Length = 463 Score = 346 bits (888), Expect = 4e-95 Identities = 157/263 (59%), Positives = 198/263 (75%), Gaps = 1/263 (0%) Frame = +2 Query: 8 WTAKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGLN 187 WTA Y E+ TL ++I +GG K+ RPKPAP+T I + +P S+DWRNV+G+N Sbjct: 185 WTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGIN 244 Query: 188 YVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPY 367 +VSPVRNQ CGSCYSFAS GMLEAR RI +NN+ PILSPQ+VV CS Y+QGC+GGFPY Sbjct: 245 FVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPY 304 Query: 368 LIAGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMEL 547 LIAGK+A+DFG+ +E+C PY G + C +DC RY+++ Y Y+GG+YG NE LM++EL Sbjct: 305 LIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLEL 364 Query: 548 VKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETS 724 V +GP+AV FEVYDDF+ Y G+YHH T + FNPFELTNHAVL+VGYG +++ Sbjct: 365 VHHGPMAVAFEVYDDFLHYKKGIYHH-------TGLRDPFNPFELTNHAVLLVGYGTDSA 417 Query: 725 SGEKFWIVKNSWGNGWGENGYFR 793 SG +WIVKNSWG GWGENGYFR Sbjct: 418 SGMDYWIVKNSWGTGWGENGYFR 440
>sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C) (Cathepsin J) (Dipeptidyl transferase) [Contains: Dipeptidyl-peptidase I exclusion domain chain; Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase I light chain] Length = 463 Score = 337 bits (863), Expect = 3e-92 Identities = 152/263 (57%), Positives = 194/263 (73%), Gaps = 1/263 (0%) Frame = +2 Query: 8 WTAKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGLN 187 WTA Y E+ TL ++I +GG K+ RPKP P+T I + +P S+DWRNV+G+N Sbjct: 185 WTATTYMEYETLTLGDMIKRSGGHSRKIPRPKPTPLTAEIQQKILHLPTSWDWRNVHGIN 244 Query: 188 YVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPY 367 +VSPVRNQ CGSCYSFAS GMLEAR RI +NN+ PILS Q+VV CS Y+QGC+GGFPY Sbjct: 245 FVSPVRNQASCGSCYSFASVGMLEARIRILTNNSQTPILSSQEVVSCSQYAQGCEGGFPY 304 Query: 368 LIAGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMEL 547 L AGK+A+DFG+ +E+C PY G + C +DC RY+++ Y Y+GG+YG NE LM++EL Sbjct: 305 LTAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLEL 364 Query: 548 VKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETS 724 V +GP+AV FEVYDDF+ Y G+YHH T + FNPFELTNHAVL+VGYG +++ Sbjct: 365 VYHGPLAVAFEVYDDFLHYQNGIYHH-------TGLRDPFNPFELTNHAVLLVGYGTDSA 417 Query: 725 SGEKFWIVKNSWGNGWGENGYFR 793 SG +WIVKNSWG WGE+GYFR Sbjct: 418 SGMDYWIVKNSWGTSWGEDGYFR 440
>sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C) (Cathepsin J) (Dipeptidyl transferase) [Contains: Dipeptidyl-peptidase I exclusion domain chain; Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase I light chain] Length = 462 Score = 335 bits (858), Expect = 1e-91 Identities = 153/263 (58%), Positives = 200/263 (76%), Gaps = 1/263 (0%) Frame = +2 Query: 8 WTAKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGLN 187 WTA Y E+ + +L ++I +G S+ ++ RPKPAP+T I + +P+S+DWRNV G+N Sbjct: 185 WTATAYKEYEKMSLRDLIRRSGHSQ-RIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVN 243 Query: 188 YVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPY 367 YVSPVRNQ CGSCYSFAS GMLEAR RI +NN+ PILSPQ+VV CSPY+QGCDGGFPY Sbjct: 244 YVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPY 303 Query: 368 LIAGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMEL 547 LIAGK+A+DFG+ +ESC PY + C ++C RY++++Y Y+GG+YG NE LM++EL Sbjct: 304 LIAGKYAQDFGVVEESCFPYTAKDSPCKpreNCLRYYSSDYYYVGGFYGGCNEALMKLEL 363 Query: 548 VKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETS 724 VK+GP+AV FEV+DDF+ Y G+YHH T FNPFELTNHAVL+VGYG + Sbjct: 364 VKHGPMAVAFEVHDDFLHYHSGIYHH-------TGLSDPFNPFELTNHAVLLVGYGRDPV 416 Query: 725 SGEKFWIVKNSWGNGWGENGYFR 793 +G ++WI+KNSWG+ WGE+GYFR Sbjct: 417 TGIEYWIIKNSWGSNWGESGYFR 439
>sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C) (Cathepsin J) (Dipeptidyl transferase) [Contains: Dipeptidyl-peptidase I exclusion domain chain; Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase I light chain] Length = 462 Score = 329 bits (843), Expect = 6e-90 Identities = 151/263 (57%), Positives = 196/263 (74%), Gaps = 1/263 (0%) Frame = +2 Query: 8 WTAKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGLN 187 WTA Y + + ++ ++I +G S ++ RPKPAPIT I + +P+S+DWRNV G+N Sbjct: 185 WTATTYRRYEKLSIRDLIRRSGHS-GRILRPKPAPITDEIQQQILSLPESWDWRNVRGIN 243 Query: 188 YVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPY 367 +VSPVRNQ CGSCYSFAS GMLEAR RI +NN+ PILSPQ+VV CSPY+QGCDGGFPY Sbjct: 244 FVSPVRNQESCGSCYSFASIGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPY 303 Query: 368 LIAGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMEL 547 LIAGK+A+DFG+ +E+C PY + C ++C RY+++ Y Y+GG+YG NE LM++EL Sbjct: 304 LIAGKYAQDFGVVEENCFPYTATDAPCKPKENCLRYYSSEYYYVGGFYGGCNEALMKLEL 363 Query: 548 VKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETS 724 VK+GP+AV FEV+DDF+ Y G+YHH T FNPFELTNHAVL+VGYG + Sbjct: 364 VKHGPMAVAFEVHDDFLHYHSGIYHH-------TGLSDPFNPFELTNHAVLLVGYGKDPV 416 Query: 725 SGEKFWIVKNSWGNGWGENGYFR 793 +G +WIVKNSWG+ WGE+GYFR Sbjct: 417 TGLDYWIVKNSWGSQWGESGYFR 439
>sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C) (Cathepsin J) (Dipeptidyl transferase) [Contains: Dipeptidyl-peptidase I exclusion domain chain; Dipeptidyl-peptidase I heavy chain 1; Dipeptidyl-peptidase I heavy chain 2; Dipeptidyl-peptidase I heavy chain 3; Dipeptidyl-peptidase I heavy chain 4; Dipeptidyl-peptidase I light chain] Length = 435 Score = 326 bits (836), Expect = 4e-89 Identities = 151/263 (57%), Positives = 194/263 (73%), Gaps = 1/263 (0%) Frame = +2 Query: 8 WTAKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGLN 187 WTA Y E+ TL +++ GG K+ RPKP P+T I + + +P S+DWRNV G N Sbjct: 160 WTATRYIEYETLTLRDMMTRVGGR--KIPRPKPTPLTAEIHEEISRLPTSWDWRNVRGTN 217 Query: 188 YVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPY 367 +VSPVRNQ CGSCY+FAS MLEAR RI +NNT PILSPQ++V CS Y+QGC+GGFPY Sbjct: 218 FVSPVRNQASCGSCYAFASTAMLEARIRILTNNTQTPILSPQEIVSCSQYAQGCEGGFPY 277 Query: 368 LIAGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMEL 547 LIAGK+A+DFG+ +E+C PY G + C DC RY+++ Y Y+GG+YGA NE LM++EL Sbjct: 278 LIAGKYAQDFGLVEEACFPYAGSDSPCK-PNDCFRYYSSEYYYVGGFYGACNEALMKLEL 336 Query: 548 VKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYG-ETS 724 V++GP+AV FEVYDDF Y G+Y+H T + FNPFELTNHAVL+VGYG +++ Sbjct: 337 VRHGPMAVAFEVYDDFFHYQKGIYYH-------TGLRDPFNPFELTNHAVLLVGYGTDSA 389 Query: 725 SGEKFWIVKNSWGNGWGENGYFR 793 SG +WIVKNSWG+ WGE+GYFR Sbjct: 390 SGMDYWIVKNSWGSRWGEDGYFR 412
>sp|Q26563|CATC_SCHMA Cathepsin C precursor Length = 454 Score = 295 bits (754), Expect = 1e-79 Identities = 145/270 (53%), Positives = 187/270 (69%), Gaps = 8/270 (2%) Frame = +2 Query: 8 WTAKDYPEFHEKTLYEVINMAGGSRSKLERP----KPAPITKSILDSVKLIPKSFDWRNV 175 W + YPE + T+ E+ N AGG +S + RP + P +K ++ +P FDW + Sbjct: 169 WRGEIYPELSKYTIDELRNRAGGVKSMVTRPSVLNRKTP-SKELISLTGNLPLEFDWTSP 227 Query: 176 --NGLNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGC 349 + V+P+RNQG CGSCY+ SA LEAR R+ SN + +PILSPQ VV+CSPYS+GC Sbjct: 228 PDGSRSPVTPIRNQGICGSCYASPSAAALEARIRLVSNFSEQPILSPQTVVDCSPYSEGC 287 Query: 350 DGGFPYLIAGKFAEDFGMAQESCNPYKGIN-GKCSTTKDCKRYFATNYKYIGGYYGATNE 526 +GGFP+LIAGK+ EDFG+ Q+ PY G + GKC+ +K+C RY+ T+Y YIGGYYGATNE Sbjct: 288 NGGFPFLIAGKYGEDFGLPQKIVIPYTGEDTGKCTVSKNCTRYYTTDYSYIGGYYGATNE 347 Query: 527 PLMRMELVKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVV 706 LM++EL+ NGP VGFEVY+DF Y G+YHH + T + FNPFELTNHAVL+V Sbjct: 348 KLMQLELISNGPFPVGFEVYEDFQFYKEGIYHHT----TVQTDHYNFNPFELTNHAVLLV 403 Query: 707 GYG-ETSSGEKFWIVKNSWGNGWGENGYFR 793 GYG + SGE +W VKNSWG WGE GYFR Sbjct: 404 GYGVDKLSGEPYWKVKNSWGVEWGEQGYFR 433
>sp|P80884|ANAN_ANACO Ananain precursor Length = 345 Score = 146 bits (369), Expect = 6e-35 Identities = 82/219 (37%), Positives = 113/219 (51%) Frame = +2 Query: 137 VKLIPKSFDWRNVNGLNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQD 316 + +P+S DWR+ V+ V+NQG CGSC++FAS +E+ Y+I+ N V LS Q Sbjct: 120 ISSVPQSIDWRDSGA---VTSVKNQGRCGSCWAFASIATVESIYKIKRGNLVS--LSEQQ 174 Query: 317 VVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKY 496 V++C+ S GC GG+ + G+A + PYK G C T + T Y Y Sbjct: 175 VLDCA-VSYGCKGGWINKAYSFIISNKGVASAAIYPYKAAKGTCKTNGVPNSAYITRYTY 233 Query: 497 IGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTSKFGFNPF 676 + N M V N PIA + +F Y GV+ GTR Sbjct: 234 V-----QRNNERNMMYAVSNQPIAAALDASGNFQHYKRGVFTGPCGTR------------ 276 Query: 677 ELTNHAVLVVGYGETSSGEKFWIVKNSWGNGWGENGYFR 793 NHA++++GYG+ SSG+KFWIV+NSWG GWGE GY R Sbjct: 277 --LNHAIVIIGYGQDSSGKKFWIVRNSWGAGWGEGGYIR 313
>sp|P00786|CATH_RAT Cathepsin H precursor (Cathepsin B3) (Cathepsin BA) [Contains: Cathepsin H mini chain; Cathepsin H heavy chain; Cathepsin H light chain] Length = 333 Score = 135 bits (341), Expect = 1e-31 Identities = 89/234 (38%), Positives = 115/234 (49%), Gaps = 3/234 (1%) Frame = +2 Query: 98 PKPAPITKS-ILDSVKLIPKSFDWRNVNGLNYVSPVRNQGGCGSCYSFASAGMLEARYRI 274 P+ TKS L P S DWR N VSPV+NQG CGSC++F++ G LE+ I Sbjct: 97 PQNCSATKSNYLRGTGPYPSSMDWRKKG--NVVSPVKNQGACGSCWTFSTTGALESAVAI 154 Query: 275 RSNNTVRPILSPQDVVECSP--YSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGINGKC 448 S + L+ Q +V+C+ + GC GG P + G+ E PY G NG+C Sbjct: 155 ASGKMM--TLAEQQLVDCAQNFNNHGCQGGLPSQAFEYILYNKGIMGEDSYPYIGKNGQC 212 Query: 449 STTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGFEVYDDFMSYSGGVYHHN 628 + F N I +E M + P++ FEV +DFM Y GVY N Sbjct: 213 KFNPEKAVAFVKNVVNI----TLNDEAAMVEAVALYNPVSFAFEVTEDFMMYKSGVYSSN 268 Query: 629 FGTRKLTTSKFGFNPFELTNHAVLVVGYGETSSGEKFWIVKNSWGNGWGENGYF 790 + T K NHAVL VGYGE +G +WIVKNSWG+ WG NGYF Sbjct: 269 --SCHKTPDK--------VNHAVLAVGYGE-QNGLLYWIVKNSWGSNWGNNGYF 311
>sp|Q90686|CATK_CHICK Cathepsin K precursor (JTAP-1) Length = 334 Score = 130 bits (327), Expect = 4e-30 Identities = 87/251 (34%), Positives = 120/251 (47%), Gaps = 1/251 (0%) Frame = +2 Query: 38 EKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGLNYVSPVRNQGG 217 + T EV+ G R RP+P T + D P + DWR YV+PV++QG Sbjct: 85 DMTSEEVVRTMTGLRVPRSRPRPNG-TLYVPDWSSRAPAAVDWRRKG---YVTPVKDQGQ 140 Query: 218 CGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDF 397 CGSC++F+S G LE + + R+ + LSPQ++V C + GC GG+ + Sbjct: 141 CGSCWAFSSVGALEGQLKRRTGKLLS--LSPQNLVYCVSNNNGCGGGYMTNAFEYVRLNR 198 Query: 398 GMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGGYYGATNEPLMRMELVKNGPIAVGF 577 G+ E PY G + C + K Y+ I NE ++ + + GP++VG Sbjct: 199 GIDSEDAYPYIGQDESCMYSPTGKAAKCRGYREI----PEDNEKALKRAVARIGPVSVGI 254 Query: 578 EV-YDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYGETSSGEKFWIVKN 754 + F YS GVY+ G NP E NHAVL VGYG G K WI+KN Sbjct: 255 DASLPSFQFYSRGVYYDT-----------GCNP-ENINHAVLAVGYG-AQKGTKHWIIKN 301 Query: 755 SWGNGWGENGY 787 SWG WG GY Sbjct: 302 SWGTEWGNKGY 312
>sp|O35186|CATK_RAT Cathepsin K precursor Length = 329 Score = 130 bits (326), Expect = 5e-30 Identities = 76/215 (35%), Positives = 109/215 (50%), Gaps = 1/215 (0%) Frame = +2 Query: 146 IPKSFDWRNVNGLNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVE 325 +P S D+R YV+PV+NQG CGSC++F+SAG LE + + ++ + LSPQ++V+ Sbjct: 115 VPDSIDYRKKG---YVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLL--ALSPQNLVD 169 Query: 326 CSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGINGKCSTTKDCKRYFATNYKYIGG 505 C + GC GG+ ++ G+ E PY G + C K Y+ I Sbjct: 170 CVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREI-- 227 Query: 506 YYGATNEPLMRMELVKNGPIAVGFEV-YDDFMSYSGGVYHHNFGTRKLTTSKFGFNPFEL 682 NE ++ + + GP++V + F YS GVY+ R + Sbjct: 228 --PVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDR------------DN 273 Query: 683 TNHAVLVVGYGETSSGEKFWIVKNSWGNGWGENGY 787 NHAVLVVGYG T G K+WI+KNSWG WG GY Sbjct: 274 VNHAVLVVGYG-TQKGNKYWIIKNSWGESWGNKGY 307
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 102,996,552 Number of Sequences: 369166 Number of extensions: 2268741 Number of successful extensions: 6735 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 5926 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6204 length of database: 68,354,980 effective HSP length: 109 effective length of database: 48,218,865 effective search space used: 7425705210 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)