Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_010_B17
(804 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 206 8e-53
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 206 8e-53
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 195 1e-49
sp|Q8HY81|CATS_CANFA Cathepsin S precursor 193 5e-49
sp|Q8HY82|CATS_SAIBB Cathepsin S precursor 192 7e-49
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 192 9e-49
sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (C... 192 9e-49
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 192 1e-48
sp|P25774|CATS_HUMAN Cathepsin S precursor 192 1e-48
sp|O70370|CATS_MOUSE Cathepsin S precursor 191 2e-48
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 206 bits (523), Expect = 8e-53
Identities = 105/272 (38%), Positives = 152/272 (55%), Gaps = 6/272 (2%)
Frame = +3
Query: 6 RRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXXX 185
RRNIWE+N+K I++HNL+ DLG +++GLN+F+DM +EF++ L+
Sbjct: 40 RRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEFKAKYLT------------- 86
Query: 186 XXXXXXLSRNDFITT------PNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGAL 347
+SR I + NN +PD DWRE G V+ V +Q N +AF+ G +
Sbjct: 87 -----EMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTM 141
Query: 348 EGQNFNLTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAYAYLADYGSELDEDYPFVGCN 527
EGQ +T S+QQ++DCS +GN+GC GG++ AY YL +G E + YP+
Sbjct: 142 EGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAVE 201
Query: 528 SNCKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDT 707
C+Y+K L K + V G E +L N V P + A+D + F Y++GIY
Sbjct: 202 GQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVDVE-SDFMMYRSGIYQSQ 260
Query: 708 SCSSNNVNHAVLVIGYGEESGQSFWIIKNSWG 803
+CS VNHAVL +GYG + G +WI+KNSWG
Sbjct: 261 TCSPLRVNHAVLAVGYGTQGGTDYWIVKNSWG 292
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 206 bits (523), Expect = 8e-53
Identities = 108/271 (39%), Positives = 154/271 (56%), Gaps = 5/271 (1%)
Frame = +3
Query: 6 RRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXXX 185
RR +WE+N+K I+ HN ++ GK F++ +N F DM +EF+ +
Sbjct: 48 RRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMM--------------G 93
Query: 186 XXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFN 365
+ P + LP S DWR+KG V+PV NQ+ +AF+A GALEGQ F
Sbjct: 94 CFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFR 153
Query: 366 LTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKY 542
T L LS+Q ++DCS GN GC GG +++A+ Y+ + G + +E YP+V + CKY
Sbjct: 154 KTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKY 213
Query: 543 DKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSN 722
+ F V+ GKE LM AV +GPIS A+DA +SF+ YK+GIY + CSS
Sbjct: 214 RPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSK 273
Query: 723 NVNHAVLVIGYGEESGQS----FWIIKNSWG 803
N++H VLV+GYG E S +W++KNSWG
Sbjct: 274 NLDHGVLVVGYGFEGANSNNSKYWLVKNSWG 304
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 195 bits (495), Expect = 1e-49
Identities = 108/271 (39%), Positives = 151/271 (55%), Gaps = 5/271 (1%)
Frame = +3
Query: 6 RRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXXX 185
RR +WE+N+K I+ HN ++ GK F++ +N F DM +EF+ +
Sbjct: 48 RRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKH------- 100
Query: 186 XXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFN 365
+ P ++P S DWREKG V+PV NQ +AF+A GALEGQ F
Sbjct: 101 -------KKGKMFQEPLFAEIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFR 153
Query: 366 LTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNS-NCK 539
T L LS+Q ++DCS GN GC GG++ A+ Y+ D G + +E YP++G ++ C
Sbjct: 154 KTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCN 213
Query: 540 YDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSS 719
Y + F + + +E LM AV +GPIS AIDA SF+ YK+GIY D CSS
Sbjct: 214 YKPECSAANDTGFVDLPQ-REKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSS 272
Query: 720 NNVNHAVLVIGYGEE---SGQSFWIIKNSWG 803
+++H VLV+GYG E S FWI+KNSWG
Sbjct: 273 KDLDHGVLVVGYGFEGTDSNNKFWIVKNSWG 303
>sp|Q8HY81|CATS_CANFA Cathepsin S precursor
Length = 331
Score = 193 bits (490), Expect = 5e-49
Identities = 108/268 (40%), Positives = 149/268 (55%), Gaps = 2/268 (0%)
Frame = +3
Query: 6 RRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXXX 185
RR IWE+NLKF+ HNL+ +G + +G+N DM +E S + S+
Sbjct: 48 RRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTGEEVISLMGSLRVPSQW------ 101
Query: 186 XXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFN 365
RN + +N KLPDS DWREKG V+ V Q + +AF+A GALE Q
Sbjct: 102 -------QRNVTYRSNSNQKLPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKL 154
Query: 366 LTKTLEILSKQQIIDCSIY-YGNSGCYGGILSKAYAYLADY-GSELDEDYPFVGCNSNCK 539
T L LS Q ++DCS YGN GC GG ++ A+ Y+ D G + + YP+ N C+
Sbjct: 155 KTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNNGIDSEASYPYKAMNGKCR 214
Query: 540 YDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSS 719
YD ++ + G E L AV N GP+S AIDAS SF Y++G+Y + SC +
Sbjct: 215 YDSKKRAATCSKYTELPFGSEDALKEAVANKGPVSVAIDASHYSFFLYRSGVYYEPSC-T 273
Query: 720 NNVNHAVLVIGYGEESGQSFWIIKNSWG 803
NVNH VLV+GYG +G+ +W++KNSWG
Sbjct: 274 QNVNHGVLVVGYGNLNGKDYWLVKNSWG 301
>sp|Q8HY82|CATS_SAIBB Cathepsin S precursor
Length = 330
Score = 192 bits (489), Expect = 7e-49
Identities = 103/268 (38%), Positives = 148/268 (55%), Gaps = 1/268 (0%)
Frame = +3
Query: 3 IRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXX 182
+RR IWE+NLKF+ HNL+ +G + +G+N DM +E S + S+
Sbjct: 47 VRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPNQW----- 101
Query: 183 XXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNF 362
RN + N LPDS DWREKG V+ V Q + +AF+A GALE Q
Sbjct: 102 --------QRNITYKSNPNQMLPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLK 153
Query: 363 NLTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAYAYLAD-YGSELDEDYPFVGCNSNCK 539
T L LS Q ++DCS YGN GC GG +++A+ Y+ D G + + YP+ + C+
Sbjct: 154 LKTGKLVSLSAQNLVDCSEKYGNKGCNGGFMTEAFQYIIDNKGIDSEASYPYKATDQKCQ 213
Query: 540 YDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSS 719
YD ++ + G+E L AV N GP+ +DAS SF Y++G+Y D +C +
Sbjct: 214 YDSKYRAATCSKYTELPYGREDVLKEAVANKGPVCVGVDASHPSFFLYRSGVYYDPAC-T 272
Query: 720 NNVNHAVLVIGYGEESGQSFWIIKNSWG 803
VNH VLVIGYG+ +G+ +W++KNSWG
Sbjct: 273 QKVNHGVLVIGYGDLNGKEYWLVKNSWG 300
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 192 bits (488), Expect = 9e-49
Identities = 108/272 (39%), Positives = 151/272 (55%), Gaps = 6/272 (2%)
Frame = +3
Query: 6 RRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXXX 185
RR +WE+N+K I+ HN ++ GK FS+ +N F DM +EF+ +
Sbjct: 48 RRAVWEKNMKMIELHNQEYSQGKHGFSMAMNAFGDMTNEEFRQVMNGFQNQKH------- 100
Query: 186 XXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFN 365
+ +++P S DWREKG V+ V NQ +AF+A GALEGQ F
Sbjct: 101 -------KKGKVFHESLVLEVPKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFR 153
Query: 366 LTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSN-CK 539
T L LS+Q ++DCS GN GC GG++ A+ Y+ D G + +E YP++G +N C
Sbjct: 154 KTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCT 213
Query: 540 YDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSS 719
Y + F + + +E LM AV +GPIS AIDA +SF+ YK+GIY D CSS
Sbjct: 214 YKPECSAANDTGFVDIPQ-REKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSS 272
Query: 720 NNVNHAVLVIGYGEESGQS----FWIIKNSWG 803
+++H VLV+GYG E S FWI+KNSWG
Sbjct: 273 KDLDHGVLVVGYGFEGTDSNSSKFWIVKNSWG 304
>sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (Catlrp-p)
Length = 333
Score = 192 bits (488), Expect = 9e-49
Identities = 113/277 (40%), Positives = 156/277 (56%), Gaps = 10/277 (3%)
Frame = +3
Query: 3 IRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXX 182
+RR +WEEN++ IK HN + LGK F++ +N+F D +EF+ +I ++
Sbjct: 46 LRRAVWEENMRMIKLHNKENSLGKNNFTMKMNKFGDQTSEEFRKSIDNIPIPAA------ 99
Query: 183 XXXXXXXLSRNDFITTPN-----NIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGAL 347
+T P+ +I LPD DWRE+G V+PV NQ +AFAAAGA+
Sbjct: 100 -------------MTDPHAQNHVSIGLPDYKDWREEGYVTPVRNQGKCGSCWAFAAAGAI 146
Query: 348 EGQNFNLTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAYAY-LADYGSELDEDYPFVGC 524
EGQ F T L LS Q ++DCS GN GC G +A+ Y L + G E + YP+ G
Sbjct: 147 EGQMFWKTGNLTPLSVQNLLDCSKTVGNKGCQSGTAHQAFEYVLKNKGLEAEATYPYEGK 206
Query: 525 NSNCKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDD 704
+ C+Y A+ ++ + E L AV +IGP+SAAIDAS SF+ Y GIY +
Sbjct: 207 DGPCRYRSENASANITDYVNLP-PNELYLWVAVASIGPVSAAIDASHDSFRFYNGGIYYE 265
Query: 705 TSCSSNNVNHAVLVIGYGEE----SGQSFWIIKNSWG 803
+CSS VNHAVLV+GYG E G ++W+IKNSWG
Sbjct: 266 PNCSSYFVNHAVLVVGYGSEGDVKDGNNYWLIKNSWG 302
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 192 bits (487), Expect = 1e-48
Identities = 106/271 (39%), Positives = 150/271 (55%), Gaps = 5/271 (1%)
Frame = +3
Query: 6 RRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXXX 185
RR +WE+N+K I+ HN ++ GK F++ +N F DM +EF+ +
Sbjct: 48 RRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPR------ 101
Query: 186 XXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFN 365
+ P + P S DWREKG V+PV NQ +AF+A GALEGQ F
Sbjct: 102 --------KGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFR 153
Query: 366 LTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKY 542
T L LS+Q ++DCS GN GC GG++ A+ Y+ D G + +E YP+ +CKY
Sbjct: 154 KTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY 213
Query: 543 DKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSN 722
+ + F + + ++A LM AV +GPIS AIDA SF YK GIY + CSS
Sbjct: 214 NPKYSVANDTGFVDIPKQEKA-LMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSE 272
Query: 723 NVNHAVLVIGYGEESGQS----FWIIKNSWG 803
+++H VLV+GYG ES +S +W++KNSWG
Sbjct: 273 DMDHGVLVVGYGFESTESDNNKYWLVKNSWG 303
>sp|P25774|CATS_HUMAN Cathepsin S precursor
Length = 331
Score = 192 bits (487), Expect = 1e-48
Identities = 106/270 (39%), Positives = 151/270 (55%), Gaps = 3/270 (1%)
Frame = +3
Query: 3 IRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXX 182
+RR IWE+NLKF+ HNL+ +G + +G+N DM +E S + S+
Sbjct: 47 VRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQW----- 101
Query: 183 XXXXXXXLSRN-DFITTPNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQN 359
RN + + PN I LPDS DWREKG V+ V Q + +AF+A GALE Q
Sbjct: 102 --------QRNITYKSNPNRI-LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQL 152
Query: 360 FNLTKTLEILSKQQIIDCSIY-YGNSGCYGGILSKAYAYLADY-GSELDEDYPFVGCNSN 533
T L LS Q ++DCS YGN GC GG ++ A+ Y+ D G + D YP+ +
Sbjct: 153 KLKTGKLVTLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQK 212
Query: 534 CKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSC 713
C+YD ++ + G+E L AV N GP+S +DA SF Y++G+Y + SC
Sbjct: 213 CQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSC 272
Query: 714 SSNNVNHAVLVIGYGEESGQSFWIIKNSWG 803
+ NVNH VLV+GYG+ +G+ +W++KNSWG
Sbjct: 273 -TQNVNHGVLVVGYGDLNGKEYWLVKNSWG 301
>sp|O70370|CATS_MOUSE Cathepsin S precursor
Length = 340
Score = 191 bits (485), Expect = 2e-48
Identities = 109/274 (39%), Positives = 150/274 (54%), Gaps = 7/274 (2%)
Frame = +3
Query: 3 IRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXX 182
+RR IWE+NLKFI HNL++ +G + VG+N+ DM +E + ++
Sbjct: 55 VRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEISCRMGALR---------- 104
Query: 183 XXXXXXXLSRNDFITTP----NNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALE 350
+SR T +N LPD+ DWREKG V+ V Q + +AF+A GALE
Sbjct: 105 -------ISRQSPKTVTFRSYSNRTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALE 157
Query: 351 GQNFNLTKTLEILSKQQIIDCSIY--YGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVG 521
GQ T L LS Q ++DCS YGN GC GG +++A+ Y+ D G E D YP+
Sbjct: 158 GQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKA 217
Query: 522 CNSNCKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYD 701
+ C Y+ + + G E L AV GP+S IDAS +SF YK+G+YD
Sbjct: 218 TDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYD 277
Query: 702 DTSCSSNNVNHAVLVIGYGEESGQSFWIIKNSWG 803
D SC + NVNH VLV+GYG G+ +W++KNSWG
Sbjct: 278 DPSC-TGNVNHGVLVVGYGTLDGKDYWLVKNSWG 310
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,110,875
Number of Sequences: 369166
Number of extensions: 1400402
Number of successful extensions: 4675
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4040
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4216
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)