Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_N23
(817 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42356|PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha (... 203 4e-52
sp|P37297|STT4_YEAST Phosphatidylinositol 4-kinase STT4 (PI... 132 9e-31
sp|Q9UBF8|PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (P... 105 2e-22
sp|O02810|PI4KB_BOVIN Phosphatidylinositol 4-kinase beta (P... 105 2e-22
sp|O08561|PI4KB_RAT Phosphatidylinositol 4-kinase beta (Ptd... 103 7e-22
sp|Q8BKC8|PI4KB_MOUSE Phosphatidylinositol 4-kinase beta (P... 103 7e-22
sp|P54677|PI4K_DICDI Phosphatidylinositol 4-kinase (PI4-kin... 102 1e-21
sp|Q9UW20|PIK1_CANAL Phosphatidylinositol 4-kinase PIK1alph... 100 6e-21
sp|P39104|PIK1_YEAST Phosphatidylinositol 4-kinase PIK1 (PI... 98 3e-20
sp|Q9UW24|PIK1A_CANAL Phosphatidylinositol 4-kinase PIK1a (... 95 3e-19
>sp|P42356|PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha (PI4-kinase) (PtdIns-4-kinase)
(PI4K-alpha)
Length = 2044
Score = 203 bits (517), Expect = 4e-52
Identities = 98/170 (57%), Positives = 130/170 (76%), Gaps = 5/170 (2%)
Frame = +1
Query: 151 RDNILRYMKPYSL-----QIKDRHNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPDIK 315
R N +R M YSL QIKDRHNGNIM+DK GHIIHIDFGFMFESSPG N+G+EPDIK
Sbjct: 1878 RYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIK 1937
Query: 316 LTKEMMMVMGGKLDSPAFQWFEQLSVQAYLVLRPYQEALVALVSLMLDSGLPCFRGQTIK 495
LT EM+M+MGGK+++ F+WF ++ V+ YL +RPY +A+V+LV+LMLD+GLPCFRGQTIK
Sbjct: 1938 LTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIK 1997
Query: 496 LLRQRFTPLMSDRDAANHYLRVLRTCCDHWRANT*FYSIFSESNSILNYY 645
LL+ RF+P M++R+AAN ++V+++C F S S + ++ YY
Sbjct: 1998 LLKHRFSPNMTEREAANFIMKVIQSC---------FLSNRSRTYDMIQYY 2038
Score = 58.2 bits (139), Expect = 3e-08
Identities = 25/34 (73%), Positives = 31/34 (91%)
Frame = -1
Query: 193 FVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHII 92
F+ SMA+YS++ +LLQIKDRHNGNIM+DK GHII
Sbjct: 1881 FIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHII 1914
Score = 42.7 bits (99), Expect = 0.001
Identities = 18/42 (42%), Positives = 28/42 (66%)
Frame = +3
Query: 6 TDSGMYDYFLSLFGEETTPSYQEARRNFVMICPCLSIIMLPL 131
TD GMYDYF +G+E+T ++Q+AR NF+ S+++ L
Sbjct: 1854 TDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLL 1895
>sp|P37297|STT4_YEAST Phosphatidylinositol 4-kinase STT4 (PI4-kinase) (PtdIns-4-kinase)
Length = 1900
Score = 132 bits (333), Expect = 9e-31
Identities = 70/145 (48%), Positives = 95/145 (65%), Gaps = 6/145 (4%)
Frame = +1
Query: 151 RDNILRYMKPYS-----LQIKDRHNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPDIK 315
R+N ++ + YS LQ KDRHNGNIM D GH +HIDFGF+F+ PG K
Sbjct: 1733 RNNFVKSLAGYSVISYLLQFKDRHNGNIMYDDQGHCLHIDFGFIFDIVPGGIKFEAVPFK 1792
Query: 316 LTKEMMMVMGGKLDSPAFQWFEQLSVQAYLVLRPYQEALVALVSLMLDSGLPCFRG-QTI 492
LTKEM+ VMGG +PA+ FE+L ++AYL RP+ EA++ V+ ML SGLPCF+G +TI
Sbjct: 1793 LTKEMVKVMGGSPQTPAYLDFEELCIKAYLAARPHVEAIIECVNPMLGSGLPCFKGHKTI 1852
Query: 493 KLLRQRFTPLMSDRDAANHYLRVLR 567
+ LR RF P +D +AA + ++R
Sbjct: 1853 RNLRARFQPQKTDHEAALYMKALIR 1877
Score = 53.1 bits (126), Expect = 9e-07
Identities = 23/34 (67%), Positives = 26/34 (76%)
Frame = -1
Query: 193 FVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHII 92
FV S+A YSV+ YLLQ KDRHNGNIM D GH +
Sbjct: 1736 FVKSLAGYSVISYLLQFKDRHNGNIMYDDQGHCL 1769
Score = 38.1 bits (87), Expect = 0.029
Identities = 17/36 (47%), Positives = 23/36 (63%)
Frame = +3
Query: 12 SGMYDYFLSLFGEETTPSYQEARRNFVMICPCLSII 119
+G+Y+YF S FG E+T +Q AR NFV S+I
Sbjct: 1711 NGLYEYFTSKFGNESTIEFQNARNNFVKSLAGYSVI 1746
>sp|Q9UBF8|PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (PtdIns 4-kinase) (PI4Kbeta)
(PI4K-beta) (NPIK) (PI4K92)
Length = 816
Score = 105 bits (261), Expect = 2e-22
Identities = 58/120 (48%), Positives = 79/120 (65%), Gaps = 3/120 (2%)
Frame = +1
Query: 181 YSLQIKDRHNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPD-IKLTKEMMMVMGGKLD 357
Y LQ+KDRHNGNI++D GHIIHIDFGF+ SSP N+GFE KLT E + VMGG LD
Sbjct: 665 YLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LD 722
Query: 358 SPAFQWFEQLSVQAYLVLRPYQEALVALVSLMLD-SGLPCFRG-QTIKLLRQRFTPLMSD 531
F +++ L +Q + R + + +V +V +M S LPCF G TI+ L++RF M++
Sbjct: 723 GDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTE 782
Score = 57.4 bits (137), Expect = 5e-08
Identities = 24/34 (70%), Positives = 28/34 (82%)
Frame = -1
Query: 193 FVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHII 92
FV S A Y +VCYLLQ+KDRHNGNI++D GHII
Sbjct: 653 FVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHII 686
Score = 31.2 bits (69), Expect = 3.6
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 2/38 (5%)
Frame = +3
Query: 18 MYDYFLSLFGEETTPSYQEARRNFVMICP--CLSIIML 125
+ DYFL G TT ++ A+RNFV C CL +L
Sbjct: 630 LLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLL 667
>sp|O02810|PI4KB_BOVIN Phosphatidylinositol 4-kinase beta (PtdIns 4-kinase) (PI4Kbeta)
(PI4K-beta)
Length = 816
Score = 105 bits (261), Expect = 2e-22
Identities = 58/120 (48%), Positives = 79/120 (65%), Gaps = 3/120 (2%)
Frame = +1
Query: 181 YSLQIKDRHNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPD-IKLTKEMMMVMGGKLD 357
Y LQ+KDRHNGNI++D GHIIHIDFGF+ SSP N+GFE KLT E + VMGG LD
Sbjct: 665 YLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LD 722
Query: 358 SPAFQWFEQLSVQAYLVLRPYQEALVALVSLMLD-SGLPCFRG-QTIKLLRQRFTPLMSD 531
F +++ L +Q + R + + +V +V +M S LPCF G TI+ L++RF M++
Sbjct: 723 GDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTE 782
Score = 54.7 bits (130), Expect = 3e-07
Identities = 23/34 (67%), Positives = 27/34 (79%)
Frame = -1
Query: 193 FVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHII 92
FV S A Y + CYLLQ+KDRHNGNI++D GHII
Sbjct: 653 FVQSCAGYCLGCYLLQVKDRHNGNILLDAEGHII 686
Score = 32.0 bits (71), Expect = 2.1
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 2/38 (5%)
Frame = +3
Query: 18 MYDYFLSLFGEETTPSYQEARRNFVMICP--CLSIIML 125
+ DYFL G TT ++ A+RNFV C CL +L
Sbjct: 630 LLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLGCYLL 667
>sp|O08561|PI4KB_RAT Phosphatidylinositol 4-kinase beta (PtdIns 4-kinase) (PI4Kbeta)
(PI4K-beta)
Length = 816
Score = 103 bits (256), Expect = 7e-22
Identities = 57/120 (47%), Positives = 79/120 (65%), Gaps = 3/120 (2%)
Frame = +1
Query: 181 YSLQIKDRHNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPD-IKLTKEMMMVMGGKLD 357
Y LQ+KDRHNGNI++D GHIIHIDFGF+ SSP N+GFE KLT E + VMGG L+
Sbjct: 665 YLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LN 722
Query: 358 SPAFQWFEQLSVQAYLVLRPYQEALVALVSLMLD-SGLPCFRG-QTIKLLRQRFTPLMSD 531
F +++ L +Q + R + + +V +V +M S LPCF G TI+ L++RF M++
Sbjct: 723 GDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTE 782
Score = 57.4 bits (137), Expect = 5e-08
Identities = 24/34 (70%), Positives = 28/34 (82%)
Frame = -1
Query: 193 FVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHII 92
FV S A Y +VCYLLQ+KDRHNGNI++D GHII
Sbjct: 653 FVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHII 686
Score = 31.2 bits (69), Expect = 3.6
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 2/38 (5%)
Frame = +3
Query: 18 MYDYFLSLFGEETTPSYQEARRNFVMICP--CLSIIML 125
+ DYFL G TT ++ A+RNFV C CL +L
Sbjct: 630 LLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLL 667
>sp|Q8BKC8|PI4KB_MOUSE Phosphatidylinositol 4-kinase beta (PtdIns 4-kinase) (PI4Kbeta)
(PI4K-beta)
Length = 801
Score = 103 bits (256), Expect = 7e-22
Identities = 57/120 (47%), Positives = 79/120 (65%), Gaps = 3/120 (2%)
Frame = +1
Query: 181 YSLQIKDRHNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPD-IKLTKEMMMVMGGKLD 357
Y LQ+KDRHNGNI++D GHIIHIDFGF+ SSP N+GFE KLT E + VMGG L+
Sbjct: 650 YLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LN 707
Query: 358 SPAFQWFEQLSVQAYLVLRPYQEALVALVSLMLD-SGLPCFRG-QTIKLLRQRFTPLMSD 531
F +++ L +Q + R + + +V +V +M S LPCF G TI+ L++RF M++
Sbjct: 708 GDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTE 767
Score = 57.4 bits (137), Expect = 5e-08
Identities = 24/34 (70%), Positives = 28/34 (82%)
Frame = -1
Query: 193 FVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHII 92
FV S A Y +VCYLLQ+KDRHNGNI++D GHII
Sbjct: 638 FVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHII 671
Score = 31.2 bits (69), Expect = 3.6
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 2/38 (5%)
Frame = +3
Query: 18 MYDYFLSLFGEETTPSYQEARRNFVMICP--CLSIIML 125
+ DYFL G TT ++ A+RNFV C CL +L
Sbjct: 615 LLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLL 652
>sp|P54677|PI4K_DICDI Phosphatidylinositol 4-kinase (PI4-kinase) (PtdIns-4-kinase)
(PI4K-alpha)
Length = 1093
Score = 102 bits (255), Expect = 1e-21
Identities = 55/139 (39%), Positives = 87/139 (62%), Gaps = 3/139 (2%)
Frame = +1
Query: 181 YSLQIKDRHNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPDIKLTKEMMMVMGGKLDS 360
Y LQIKDRHNGNI+IDK GHI+HIDFGF+ +SPGN KLT+E++ VMGG + S
Sbjct: 940 YILQIKDRHNGNILIDKEGHIVHIDFGFILSNSPGNISFESAPFKLTQELVDVMGG-IQS 998
Query: 361 PAFQWFEQLSVQAYLVLRPYQEALVALVSLMLDS-GLPCFRG--QTIKLLRQRFTPLMSD 531
FQ+F+ L V+ + R + +++L+ +M+ + CF G + I+ L+ RF +++
Sbjct: 999 GQFQYFKVLCVRGLIEARKQVDKIISLIEIMMSGPKMSCFVGGKEVIEQLKARFFLDVNE 1058
Query: 532 RDAANHYLRVLRTCCDHWR 588
R+ + ++ DH++
Sbjct: 1059 RECSTLVENLISYSIDHFK 1077
Score = 60.1 bits (144), Expect = 7e-09
Identities = 25/34 (73%), Positives = 31/34 (91%)
Frame = -1
Query: 193 FVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHII 92
F+ SMA+YS+V Y+LQIKDRHNGNI+IDK GHI+
Sbjct: 928 FIESMAAYSIVTYILQIKDRHNGNILIDKEGHIV 961
>sp|Q9UW20|PIK1_CANAL Phosphatidylinositol 4-kinase PIK1alpha (PI4-kinase)
(PtdIns-4-kinase)
Length = 977
Score = 100 bits (248), Expect = 6e-21
Identities = 60/123 (48%), Positives = 77/123 (62%), Gaps = 4/123 (3%)
Frame = +1
Query: 181 YSLQIKDRHNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFE-PDIKLTKEMMMVMGGKLD 357
Y LQIKDRHNGNIM+D GHIIHIDFGF+ +SPG ++GFE KLT E + ++GG +D
Sbjct: 823 YVLQIKDRHNGNIMVDGDGHIIHIDFGFLLSNSPG-SVGFEAAPFKLTVEYVELLGG-VD 880
Query: 358 SPAFQWFEQLSVQAYLVLRPYQEALVALVSLM-LDSGLPCFRG--QTIKLLRQRFTPLMS 528
S + F L Q + LR E ++ +V LM DS LPCF T LL+QR ++
Sbjct: 881 SEIYSQFVYLCKQCFKSLRDNSEEIIEIVELMQKDSTLPCFNNGENTSVLLKQRLQLQLN 940
Query: 529 DRD 537
D D
Sbjct: 941 DED 943
Score = 59.3 bits (142), Expect = 1e-08
Identities = 24/34 (70%), Positives = 30/34 (88%)
Frame = -1
Query: 193 FVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHII 92
F S+A+YS++CY+LQIKDRHNGNIM+D GHII
Sbjct: 811 FAKSLAAYSIICYVLQIKDRHNGNIMVDGDGHII 844
>sp|P39104|PIK1_YEAST Phosphatidylinositol 4-kinase PIK1 (PI4-kinase) (PtdIns-4-kinase)
Length = 1066
Score = 97.8 bits (242), Expect = 3e-20
Identities = 56/123 (45%), Positives = 81/123 (65%), Gaps = 4/123 (3%)
Frame = +1
Query: 181 YSLQIKDRHNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFE-PDIKLTKEMMMVMGGKLD 357
Y LQ+KDRHNGNIMID GH+ HIDFGFM +SPG ++GFE KLT E + ++GG ++
Sbjct: 912 YLLQVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPG-SVGFEAAPFKLTYEYIELLGG-VE 969
Query: 358 SPAFQWFEQLSVQAYLVLRPYQEALVALVSLM-LDSGLPCFRG--QTIKLLRQRFTPLMS 528
AF+ F +L+ ++ LR Y + +V++ +M D+ PCF QT LRQRF +S
Sbjct: 970 GEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLS 1029
Query: 529 DRD 537
+++
Sbjct: 1030 EKE 1032
Score = 60.1 bits (144), Expect = 7e-09
Identities = 24/33 (72%), Positives = 29/33 (87%)
Frame = -1
Query: 193 FVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHI 95
F S+A+YSV+CYLLQ+KDRHNGNIMID GH+
Sbjct: 900 FASSLAAYSVICYLLQVKDRHNGNIMIDNEGHV 932
>sp|Q9UW24|PIK1A_CANAL Phosphatidylinositol 4-kinase PIK1a (PI4-kinase) (PtdIns-4-kinase)
Length = 956
Score = 94.7 bits (234), Expect = 3e-19
Identities = 59/123 (47%), Positives = 75/123 (60%), Gaps = 4/123 (3%)
Frame = +1
Query: 181 YSLQIKDRHNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFE-PDIKLTKEMMMVMGGKLD 357
Y LQIKDRHNGNIM+D GHIIHIDFGF+ +SPG ++GFE KLT E + V+GG L+
Sbjct: 802 YVLQIKDRHNGNIMLDHEGHIIHIDFGFLLSNSPG-SVGFEAAPFKLTSEYVEVLGG-LE 859
Query: 358 SPAFQWFEQLSVQAYLVLRPYQEALVALVSLM-LDSGLPCFRG--QTIKLLRQRFTPLMS 528
S A+ F + LR +V++V LM S LPCF T LL+QR +S
Sbjct: 860 SKAYLKFVDTCKNCFKALRKEWGQIVSIVELMQKGSSLPCFNNGDNTSVLLQQRLQLHLS 919
Query: 529 DRD 537
D +
Sbjct: 920 DEE 922
Score = 61.6 bits (148), Expect = 2e-09
Identities = 25/34 (73%), Positives = 31/34 (91%)
Frame = -1
Query: 193 FVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHII 92
F +S+ASYS++CY+LQIKDRHNGNIM+D GHII
Sbjct: 790 FAISLASYSIICYVLQIKDRHNGNIMLDHEGHII 823
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,278,452
Number of Sequences: 369166
Number of extensions: 1617840
Number of successful extensions: 4092
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3753
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4053
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7811456130
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)