Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_M03
(795 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 231 2e-60
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 230 3e-60
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 230 3e-60
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 230 3e-60
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 229 5e-60
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 229 5e-60
sp|P55097|CATK_MOUSE Cathepsin K precursor 227 3e-59
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 227 3e-59
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 226 4e-59
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 226 6e-59
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 231 bits (589), Expect = 2e-60
Identities = 123/271 (45%), Positives = 172/271 (63%), Gaps = 7/271 (2%)
Frame = +1
Query: 4 TSHLIINEEFNAEWEGFKTKFNKDYTA-IDELVRKTIWIENIKYIQHHNVKYDLGHHSHS 180
+S L E + +WE +K + K Y + +DE+ R+ IW +N+K+I HN++ LG H++
Sbjct: 14 SSALYPEEILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYE 73
Query: 181 LGINEFSDLTYKEFEK----LYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNV 348
L +N D+T +E + L + + ND + Y+P PDS+D+R KGYVT V
Sbjct: 74 LAMNHLGDMTSEEVVQKMTGLKVPPSHSRSNDTL-YIPDWE-GRTPDSIDYRKKGYVTPV 131
Query: 349 KNQGQCGSCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYI- 525
KNQGQCGSCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+
Sbjct: 132 KNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQ 191
Query: 526 SSHGIESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAID 705
+ GI+SED YPY + NC+++ + A C+G++ I NEK L AVA VGP+SVAID
Sbjct: 192 KNRGIDSEDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAID 251
Query: 706 VGY-SFQQYKQGVYYEAKCDPTIQNHAVLVV 795
SFQ Y +GVYY+ C+ NHAVL V
Sbjct: 252 ASLTSFQFYSKGVYYDENCNSDNLNHAVLAV 282
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 230 bits (587), Expect = 3e-60
Identities = 108/255 (42%), Positives = 163/255 (63%), Gaps = 4/255 (1%)
Frame = +1
Query: 43 WEGFKTKFNKDYTAIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFSDLTYKEF 222
W +K +NK+Y D+ R+ IW +N+K+IQ HN+++DLG +++LG+N+F+D+T++EF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 223 EKLYLLSKNIEYNDGIDYLPPLNIDN--LPDSVDWRTKGYVTNVKNQGQCGSCWAFSTTG 396
+ YL + +D + + P +N +PD +DWR GYVT VK+QG CGSCWAFSTTG
Sbjct: 81 KAKYLTEMS-RASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTG 139
Query: 397 SLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSHGIESEDNYPYQA 570
++EGQ+ + + + SEQQLVDC N+GC+GG M A++Y+ G+E+E +YPY A
Sbjct: 140 TMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTA 199
Query: 571 KQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGYSFQQYKQGVYYE 750
+G C ++K VA G+ ++S +E +L V P +VA+DV F Y+ G+Y
Sbjct: 200 VEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVDVESDFMMYRSGIYQS 259
Query: 751 AKCDPTIQNHAVLVV 795
C P NHAVL V
Sbjct: 260 QTCSPLRVNHAVLAV 274
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 230 bits (587), Expect = 3e-60
Identities = 130/266 (48%), Positives = 171/266 (64%), Gaps = 14/266 (5%)
Frame = +1
Query: 40 EWEGFKTKFNKDYT-AIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFSDLTYK 216
EW FK + K+Y +E R I+ EN I HN ++ G S L +N+++DL +
Sbjct: 28 EWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHH 87
Query: 217 EFEKL-----YLLSKNIEYND----GIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCG 369
EF +L Y L K + D G+ ++ P ++ LP SVDWRTKG VT VK+QG CG
Sbjct: 88 EFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCG 146
Query: 370 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSH-GI 540
SCWAFS+TG+LEGQHFRK VL ++SEQ LVDC TK N+GCNGG M+ AF YI + GI
Sbjct: 147 SCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGI 206
Query: 541 ESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-S 717
++E +YPY+A +C F+K V A +GF +I +EK +A AVATVGP+SVAID + S
Sbjct: 207 DTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHES 266
Query: 718 FQQYKQGVYYEAKCDPTIQNHAVLVV 795
FQ Y +GVY E +CD +H VLVV
Sbjct: 267 FQFYSEGVYNEPQCDAQNLDHGVLVV 292
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 230 bits (587), Expect = 3e-60
Identities = 125/258 (48%), Positives = 162/258 (62%), Gaps = 7/258 (2%)
Frame = +1
Query: 43 WEGFKTKFNKDYT-AIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFSDLTYKE 219
WE FK K+ + Y A ++ R+ I+ +N KYI+ N KY+ G + +L +N+F D+T +E
Sbjct: 20 WEHFKGKYGRQYVDAEEDSYRRVIFEQNQKYIEEFNKKYENGEVTFNLAMNKFGDMTLEE 79
Query: 220 FEKLYLLSKNIEYNDG--IDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGSCWAFSTT 393
F + + NI + P VDWRTKG VT VK+QGQCGSCWAFSTT
Sbjct: 80 FNAV--MKGNIPRRSAPVSVFYPKKETGPQATEVDWRTKGAVTPVKDQGQCGSCWAFSTT 137
Query: 394 GSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYI-SSHGIESEDNYPY 564
GSLEGQHF K L +++EQQLVDC GCNGGWMN AF+YI +++GI++E YPY
Sbjct: 138 GSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPY 197
Query: 565 QAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQYKQGV 741
+A+ G+C FD + V A C G NI S +E L AV +GPISV ID + SFQ Y GV
Sbjct: 198 EARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGV 257
Query: 742 YYEAKCDPTIQNHAVLVV 795
YYE C P+ +HAVL V
Sbjct: 258 YYEPSCSPSYLDHAVLAV 275
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 229 bits (585), Expect = 5e-60
Identities = 122/263 (46%), Positives = 168/263 (63%), Gaps = 6/263 (2%)
Frame = +1
Query: 25 EEFNAEWEGFKTKFNKDYT-AIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 201
E + WE +K K Y +DE+ R+ IW +N+KYI HN++ LG H++ L +N
Sbjct: 20 EILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLG 79
Query: 202 DLTYKEF-EKLYLLSKNIEYNDGID--YLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGS 372
D+T +E +K+ L + ++ D Y+P PDSVD+R KGYVT VKNQGQCGS
Sbjct: 80 DMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWE-GRAPDSVDYRKKGYVTPVKNQGQCGS 138
Query: 373 CWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYI-SSHGIESE 549
CWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+SE
Sbjct: 139 CWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSE 198
Query: 550 DNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQ 726
D YPY ++ +C+++ + A C+G++ I NEK L AVA VGP+SVAID SFQ
Sbjct: 199 DAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQF 258
Query: 727 YKQGVYYEAKCDPTIQNHAVLVV 795
Y +GVYY+ C+ NHAVL V
Sbjct: 259 YSKGVYYDESCNSDNLNHAVLAV 281
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 229 bits (585), Expect = 5e-60
Identities = 122/264 (46%), Positives = 169/264 (64%), Gaps = 7/264 (2%)
Frame = +1
Query: 25 EEFNAEWEGFKTKFNKDYTA-IDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 201
E + WE +K K Y + +DE+ R+ IW +N+KYI HN++ LG H++ L +N
Sbjct: 20 EILDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLG 79
Query: 202 DLTYKEFEK----LYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCG 369
D+T +E + L + + + ND + Y+P PDSVD+R KGYVT VKNQGQCG
Sbjct: 80 DMTNEEVVQKMTGLKVPASHSRSNDTL-YIPDWE-GRAPDSVDYRKKGYVTPVKNQGQCG 137
Query: 370 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYI-SSHGIES 546
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+S
Sbjct: 138 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDS 197
Query: 547 EDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQ 723
ED YPY ++ +C+++ + A C+G++ I NEK L AVA VGP+SVAID SFQ
Sbjct: 198 EDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 724 QYKQGVYYEAKCDPTIQNHAVLVV 795
Y +GVYY+ C+ NHAVL V
Sbjct: 258 FYSKGVYYDESCNSDNLNHAVLAV 281
>sp|P55097|CATK_MOUSE Cathepsin K precursor
Length = 329
Score = 227 bits (578), Expect = 3e-59
Identities = 120/263 (45%), Positives = 166/263 (63%), Gaps = 6/263 (2%)
Frame = +1
Query: 25 EEFNAEWEGFKTKFNKDYTA-IDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 201
E + +WE +K K Y + +DE+ R+ IW +N+K I HN++ LG H++ L +N
Sbjct: 20 EMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLG 79
Query: 202 DLTYKEFEKLYL---LSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGS 372
D+T +E + + + Y++ Y P +PDS+D+R KGYVT VKNQGQCGS
Sbjct: 80 DMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWE-GRVPDSIDYRKKGYVTPVKNQGQCGS 138
Query: 373 CWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYISSH-GIESE 549
CWAFS+ G+LEGQ +K L +S Q LVDCVT+N GC GG+M AF+Y+ + GI+SE
Sbjct: 139 CWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTENYGCGGGYMTTAFQYVQQNGGIDSE 198
Query: 550 DNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQ 726
D YPY + +C+++ + A C+G++ I NEK L AVA VGPISV+ID SFQ
Sbjct: 199 DAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQF 258
Query: 727 YKQGVYYEAKCDPTIQNHAVLVV 795
Y +GVYY+ CD NHAVLVV
Sbjct: 259 YSRGVYYDENCDRDNVNHAVLVV 281
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 227 bits (578), Expect = 3e-59
Identities = 120/264 (45%), Positives = 168/264 (63%), Gaps = 7/264 (2%)
Frame = +1
Query: 25 EEFNAEWEGFKTKFNKDYTA-IDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 201
E + +WE +K ++K Y + +DE+ R+ IW +N+K+I HN++ LG H++ L +N
Sbjct: 20 EILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLG 79
Query: 202 DLTYKEFEK----LYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCG 369
D+T +E + L + ND + Y+P PDS+D+R KGYVT VKNQGQCG
Sbjct: 80 DMTSEEVVQKMTGLKVPPSRSHSNDTL-YIPDWE-GRTPDSIDYRKKGYVTPVKNQGQCG 137
Query: 370 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYIS-SHGIES 546
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+S
Sbjct: 138 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGGYMTNAFQYVQRNRGIDS 197
Query: 547 EDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQ 723
ED YPY + +C+++ + A C+G++ I NEK L AVA VGP+SVAID SFQ
Sbjct: 198 EDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 724 QYKQGVYYEAKCDPTIQNHAVLVV 795
Y +GVYY+ C NHAVL V
Sbjct: 258 FYSKGVYYDENCSSDNVNHAVLAV 281
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 226 bits (577), Expect = 4e-59
Identities = 124/265 (46%), Positives = 168/265 (63%), Gaps = 4/265 (1%)
Frame = +1
Query: 13 LIINEEFNAEWEGFKTKFNKDYTAIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGIN 192
L + A+W +K N+ Y +E R+ +W +N+K I+ HN +Y G HS ++ +N
Sbjct: 19 LTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMN 78
Query: 193 EFSDLTYKEFEKLYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGS 372
F D+T +EF ++ +N + G + PL + P SVDWR KGYVT VKNQGQCGS
Sbjct: 79 AFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYE-APRSVDWREKGYVTPVKNQGQCGS 137
Query: 373 CWAFSTTGSLEGQHFRKHKVLQNISEQQLVDC--VTKNSGCNGGWMNIAFEYISSH-GIE 543
CWAFS TG+LEGQ FRK L ++SEQ LVDC N GCNGG M+ AF+Y+ + G++
Sbjct: 138 CWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLD 197
Query: 544 SEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SF 720
SE++YPY+A + +C ++ VAN GF +I EK L AVATVGPISVAID G+ SF
Sbjct: 198 SEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESF 256
Query: 721 QQYKQGVYYEAKCDPTIQNHAVLVV 795
YK+G+Y+E C +H VLVV
Sbjct: 257 LFYKEGIYFEPDCSSEDMDHGVLVV 281
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 226 bits (576), Expect = 6e-59
Identities = 121/262 (46%), Positives = 164/262 (62%), Gaps = 4/262 (1%)
Frame = +1
Query: 22 NEEFNAEWEGFKTKFNKDYTAIDELVRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 201
++ + +W +K + Y A +E R+ +W +N+K I+ HN +Y G H ++ +N F
Sbjct: 22 DQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFG 81
Query: 202 DLTYKEFEKLYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGSCWA 381
D+T +EF ++ +N ++ G + PL +D LP SVDWR KGYVT VKNQ QCGSCWA
Sbjct: 82 DMTNEEFRQMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWA 140
Query: 382 FSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSH-GIESED 552
FS TG+LEGQ FRK L ++SEQ LVDC N GCNGG+M AF+Y+ + G++SE+
Sbjct: 141 FSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEE 200
Query: 553 NYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQY 729
+YPY A C + VAN GF + EK L AVATVGPISVA+D G+ SFQ Y
Sbjct: 201 SYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFY 260
Query: 730 KQGVYYEAKCDPTIQNHAVLVV 795
K G+Y+E C +H VLVV
Sbjct: 261 KSGIYFEPDCSSKNLDHGVLVV 282
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.317 0.134 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,154,999
Number of Sequences: 369166
Number of extensions: 1928621
Number of successful extensions: 5871
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5176
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5421
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7473924075
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)