Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_K12
(793 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P79896|ADHX_SPAAU Alcohol dehydrogenase class III (S-(hy... 307 2e-83
sp|P80467|ADHX_UROHA Alcohol dehydrogenase class III (Gluta... 306 3e-83
sp|P81600|ADHH_GADMO Alcohol dehydrogenase class III H chai... 304 2e-82
sp|P11766|ADHX_HUMAN Alcohol dehydrogenase class III chi ch... 303 3e-82
sp|P19854|ADHX_HORSE Alcohol dehydrogenase class III chain ... 301 1e-81
sp|O19053|ADHX_RABIT Alcohol dehydrogenase class III chain ... 299 7e-81
sp|P12711|ADHX_RAT Alcohol dehydrogenase class III (Alcohol... 295 7e-80
sp|P81601|ADHL_GADMO Alcohol dehydrogenase class III L chai... 294 2e-79
sp|P81431|ADHX_OCTVU Alcohol dehydrogenase class III (Gluta... 293 4e-79
sp|P28474|ADHX_MOUSE Alcohol dehydrogenase class III (Alcoh... 290 2e-78
>sp|P79896|ADHX_SPAAU Alcohol dehydrogenase class III (S-(hydroxymethyl)glutathione
dehydrogenase) (Glutathione-dependent formaldehyde
dehydrogenase) (FDH) (FALDH)
Length = 376
Score = 307 bits (787), Expect = 2e-83
Identities = 148/229 (64%), Positives = 180/229 (78%)
Frame = +1
Query: 16 GCSTFSEYTVVAEISLAKISKEAPLNRVCLLGCGITTGFGAAINTAKVEPGSICAVWGLG 195
G STFSEYTVVA+ISLAK++++AP+++VCLLGCGI+TG+GAA+NTAKVEPGS CAV+GLG
Sbjct: 144 GTSTFSEYTVVADISLAKVNEKAPMDKVCLLGCGISTGYGAALNTAKVEPGSTCAVFGLG 203
Query: 196 AVGLATIMGCKXXXXXXXXXXXXNTNKFPYAKQFGATECVNPLDYKDKPFQQVIIDMTDG 375
AVGLA IMGCK N KF AK+FGATE VNP D+ KP Q+V+++MTDG
Sbjct: 204 AVGLAVIMGCKVAGATRIIGIDLNPAKFETAKEFGATEFVNPKDHS-KPIQEVLVEMTDG 262
Query: 376 GCDFTFECVGNVETMRCALEACHKXXXXXXXXXXXXXXKEISTRPFQLVTGRVWKGTAFG 555
G D++FEC+GNV+ MR ALEACHK +EISTRPFQLVTGRVWKGTAFG
Sbjct: 263 GVDYSFECIGNVQIMRAALEACHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWKGTAFG 322
Query: 556 GFKSRDSVPKLVNDYLDKKIKIDEFVTHEMPLKSINEAFDLMHEGKSLR 702
G+KS +SVPKLV DY+ KK+K+DEFVTH +P + INE F+LMH GKS+R
Sbjct: 323 GWKSVESVPKLVEDYMSKKLKVDEFVTHTLPFEKINEGFELMHAGKSIR 371
>sp|P80467|ADHX_UROHA Alcohol dehydrogenase class III (Glutathione-dependent formaldehyde
dehydrogenase) (FDH)
Length = 373
Score = 306 bits (785), Expect = 3e-83
Identities = 146/230 (63%), Positives = 180/230 (78%)
Frame = +1
Query: 16 GCSTFSEYTVVAEISLAKISKEAPLNRVCLLGCGITTGFGAAINTAKVEPGSICAVWGLG 195
G STFSEYTVVA+ISL KI+ APL++VCLLGCG++TG+GAA+NTAKVEPGS CAV+GLG
Sbjct: 141 GTSTFSEYTVVADISLTKINASAPLDKVCLLGCGVSTGYGAALNTAKVEPGSTCAVFGLG 200
Query: 196 AVGLATIMGCKXXXXXXXXXXXXNTNKFPYAKQFGATECVNPLDYKDKPFQQVIIDMTDG 375
VGLA IMGCK N +KF AK+FGATEC++P D+K KP Q+V+I+MTDG
Sbjct: 201 GVGLAVIMGCKVAGASRIIGIDLNKDKFAKAKEFGATECISPADFK-KPIQEVLIEMTDG 259
Query: 376 GCDFTFECVGNVETMRCALEACHKXXXXXXXXXXXXXXKEISTRPFQLVTGRVWKGTAFG 555
G D++FEC+GNV MR ALEACHK +EI+TRPFQLVTGR WKGTAFG
Sbjct: 260 GVDYSFECIGNVGVMRAALEACHKGWGVSVIVGVAAAGQEIATRPFQLVTGRTWKGTAFG 319
Query: 556 GFKSRDSVPKLVNDYLDKKIKIDEFVTHEMPLKSINEAFDLMHEGKSLRA 705
G+KS +SVPKLV++Y+ KK+K+DEFVTH +P + INEAF+LMH GKS+R+
Sbjct: 320 GWKSVESVPKLVDEYMSKKMKVDEFVTHTLPFEQINEAFELMHAGKSIRS 369
>sp|P81600|ADHH_GADMO Alcohol dehydrogenase class III H chain (Glutathione-dependent
formaldehyde dehydrogenase) (FDH)
Length = 375
Score = 304 bits (779), Expect = 2e-82
Identities = 147/229 (64%), Positives = 177/229 (77%)
Frame = +1
Query: 16 GCSTFSEYTVVAEISLAKISKEAPLNRVCLLGCGITTGFGAAINTAKVEPGSICAVWGLG 195
G STFSEYTVVA+ISLA + +APL++VCLLGCGI+TG+GAA+NTAKVEPGS CAV+GLG
Sbjct: 143 GTSTFSEYTVVADISLANVDPKAPLDKVCLLGCGISTGYGAALNTAKVEPGSTCAVFGLG 202
Query: 196 AVGLATIMGCKXXXXXXXXXXXXNTNKFPYAKQFGATECVNPLDYKDKPFQQVIIDMTDG 375
AVGLA IMGCK N KF A +FGATEC+NP D+ +P Q+V+++MTDG
Sbjct: 203 AVGLAAIMGCKVAGATRIIGVDINPEKFGKAAEFGATECLNPKDHA-RPVQEVLVEMTDG 261
Query: 376 GCDFTFECVGNVETMRCALEACHKXXXXXXXXXXXXXXKEISTRPFQLVTGRVWKGTAFG 555
G D++FEC+GNVE MR ALEACHK +EI+TRPFQLVTGRVWK TAFG
Sbjct: 262 GVDYSFECIGNVEIMRSALEACHKGWGESVIIGVAGAGQEIATRPFQLVTGRVWKATAFG 321
Query: 556 GFKSRDSVPKLVNDYLDKKIKIDEFVTHEMPLKSINEAFDLMHEGKSLR 702
G+KS +SVPKLV DY++KK+K+DEFVTH +P SINE FDLMH GKS+R
Sbjct: 322 GWKSVESVPKLVEDYMNKKLKVDEFVTHTLPFDSINEGFDLMHAGKSIR 370
>sp|P11766|ADHX_HUMAN Alcohol dehydrogenase class III chi chain (Glutathione-dependent
formaldehyde dehydrogenase) (FDH)
Length = 374
Score = 303 bits (777), Expect = 3e-82
Identities = 145/229 (63%), Positives = 178/229 (77%)
Frame = +1
Query: 16 GCSTFSEYTVVAEISLAKISKEAPLNRVCLLGCGITTGFGAAINTAKVEPGSICAVWGLG 195
G STFSEYTVVA+IS+AKI APL++VCLLGCGI+TG+GAA+NTAK+EPGS+CAV+GLG
Sbjct: 142 GTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLG 201
Query: 196 AVGLATIMGCKXXXXXXXXXXXXNTNKFPYAKQFGATECVNPLDYKDKPFQQVIIDMTDG 375
VGLA IMGCK N +KF AK+FGATEC+NP D+ KP Q+V+I+MTDG
Sbjct: 202 GVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFS-KPIQEVLIEMTDG 260
Query: 376 GCDFTFECVGNVETMRCALEACHKXXXXXXXXXXXXXXKEISTRPFQLVTGRVWKGTAFG 555
G D++FEC+GNV+ MR ALEACHK +EI+TRPFQLVTGR WKGTAFG
Sbjct: 261 GVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFG 320
Query: 556 GFKSRDSVPKLVNDYLDKKIKIDEFVTHEMPLKSINEAFDLMHEGKSLR 702
G+KS +SVPKLV++Y+ KKIK+DEFVTH + IN+AF+LMH GKS+R
Sbjct: 321 GWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIR 369
>sp|P19854|ADHX_HORSE Alcohol dehydrogenase class III chain (Glutathione-dependent
formaldehyde dehydrogenase) (FDH) (FALDH)
Length = 373
Score = 301 bits (772), Expect = 1e-81
Identities = 143/229 (62%), Positives = 177/229 (77%)
Frame = +1
Query: 16 GCSTFSEYTVVAEISLAKISKEAPLNRVCLLGCGITTGFGAAINTAKVEPGSICAVWGLG 195
G STFSEYTVVA+IS+AKI APL++VCLLGCG++TG+GAA+NTAKVEPGS CA++GLG
Sbjct: 141 GTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGVSTGYGAAVNTAKVEPGSTCAIFGLG 200
Query: 196 AVGLATIMGCKXXXXXXXXXXXXNTNKFPYAKQFGATECVNPLDYKDKPFQQVIIDMTDG 375
VGLA IMGCK N +KF AK+FGA+EC+NP D+ KP Q+V+I+MTDG
Sbjct: 201 GVGLAVIMGCKVAGASRIIGVDINKDKFAKAKEFGASECINPQDFS-KPIQEVLIEMTDG 259
Query: 376 GCDFTFECVGNVETMRCALEACHKXXXXXXXXXXXXXXKEISTRPFQLVTGRVWKGTAFG 555
G D++FEC+GNV+ MR ALEACHK +EI+TRPFQLVTGR WKGTAFG
Sbjct: 260 GVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFG 319
Query: 556 GFKSRDSVPKLVNDYLDKKIKIDEFVTHEMPLKSINEAFDLMHEGKSLR 702
G+KS +S+PKLV++Y+ KKIK+DEFVTH + INEAF+LMH GKS+R
Sbjct: 320 GWKSVESIPKLVSEYMSKKIKVDEFVTHSLSFDQINEAFELMHAGKSIR 368
>sp|O19053|ADHX_RABIT Alcohol dehydrogenase class III chain (S-(hydroxymethyl)glutathione
dehydrogenase) (Glutathione-dependent formaldehyde
dehydrogenase) (FDH) (FALDH)
Length = 374
Score = 299 bits (765), Expect = 7e-81
Identities = 144/229 (62%), Positives = 175/229 (76%)
Frame = +1
Query: 16 GCSTFSEYTVVAEISLAKISKEAPLNRVCLLGCGITTGFGAAINTAKVEPGSICAVWGLG 195
G STFSEYTVVA+IS+AKI APL++VCLLGCGI+TG+GAA+NTAKVEPGS CAV+GLG
Sbjct: 142 GTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAALNTAKVEPGSTCAVFGLG 201
Query: 196 AVGLATIMGCKXXXXXXXXXXXXNTNKFPYAKQFGATECVNPLDYKDKPFQQVIIDMTDG 375
VGLA IMGCK N +KF AK+FGATEC+NP D+ KP Q+V+++ TDG
Sbjct: 202 GVGLAAIMGCKAAGASRIIAVDINKDKFARAKEFGATECINPQDFS-KPIQEVLVEKTDG 260
Query: 376 GCDFTFECVGNVETMRCALEACHKXXXXXXXXXXXXXXKEISTRPFQLVTGRVWKGTAFG 555
G D++FEC+GNV+ MR ALEACHK +EISTRPFQLVTGR WKGTAFG
Sbjct: 261 GVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAGAGEEISTRPFQLVTGRTWKGTAFG 320
Query: 556 GFKSRDSVPKLVNDYLDKKIKIDEFVTHEMPLKSINEAFDLMHEGKSLR 702
G+KS +SVPKLV++Y+ KKI +DEFVT+ + INEAF+LMH GKS+R
Sbjct: 321 GWKSVESVPKLVSEYMSKKINVDEFVTNTLSFDQINEAFELMHSGKSIR 369
>sp|P12711|ADHX_RAT Alcohol dehydrogenase class III (Alcohol dehydrogenase 2)
(Glutathione-dependent formaldehyde dehydrogenase) (FDH)
(FALDH) (Alcohol dehydrogenase-B2)
Length = 373
Score = 295 bits (756), Expect = 7e-80
Identities = 145/229 (63%), Positives = 173/229 (75%)
Frame = +1
Query: 16 GCSTFSEYTVVAEISLAKISKEAPLNRVCLLGCGITTGFGAAINTAKVEPGSICAVWGLG 195
G STFSEYTVVA+IS+AKI APL++VCLLGCGI+TG+GAA+NTAKVEPGS CAV+GLG
Sbjct: 141 GTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLG 200
Query: 196 AVGLATIMGCKXXXXXXXXXXXXNTNKFPYAKQFGATECVNPLDYKDKPFQQVIIDMTDG 375
VGLA IMGCK N +KF AK+FGATEC+NP D+ K Q+V+I+MTDG
Sbjct: 201 GVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGATECINPQDFS-KSIQEVLIEMTDG 259
Query: 376 GCDFTFECVGNVETMRCALEACHKXXXXXXXXXXXXXXKEISTRPFQLVTGRVWKGTAFG 555
G DF+FEC+GNV+ MR ALEA HK +EISTRPFQLVTGR WKGTAFG
Sbjct: 260 GVDFSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFG 319
Query: 556 GFKSRDSVPKLVNDYLDKKIKIDEFVTHEMPLKSINEAFDLMHEGKSLR 702
G+KS +SVPKLV++Y+ KKIK+DEFVT + IN+AFDLMH G S+R
Sbjct: 320 GWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINKAFDLMHSGNSIR 368
>sp|P81601|ADHL_GADMO Alcohol dehydrogenase class III L chain (Glutathione-dependent
formaldehyde dehydrogenase) (FDH)
Length = 375
Score = 294 bits (752), Expect = 2e-79
Identities = 142/229 (62%), Positives = 176/229 (76%)
Frame = +1
Query: 16 GCSTFSEYTVVAEISLAKISKEAPLNRVCLLGCGITTGFGAAINTAKVEPGSICAVWGLG 195
G STFSEYTVVAEISLAK+ ++APL++VCLLGC I+TG+GAA+NTAKVE GS CAV+GLG
Sbjct: 143 GSSTFSEYTVVAEISLAKVHEKAPLDKVCLLGCAISTGYGAALNTAKVEAGSTCAVFGLG 202
Query: 196 AVGLATIMGCKXXXXXXXXXXXXNTNKFPYAKQFGATECVNPLDYKDKPFQQVIIDMTDG 375
A+GLA IMGC+ N +KF AK+FGAT+ VNP D+ KP +QV+++MTDG
Sbjct: 203 ALGLAVIMGCQAAGASRIIAIDVNPDKFRIAKEFGATDLVNPKDHS-KPVEQVLVEMTDG 261
Query: 376 GCDFTFECVGNVETMRCALEACHKXXXXXXXXXXXXXXKEISTRPFQLVTGRVWKGTAFG 555
G D++FECVGN+ MR ALEACHK +EISTRPFQLVTGR WKGTAFG
Sbjct: 262 GVDYSFECVGNIAVMRAALEACHKGWGTSVIIGVAAAGQEISTRPFQLVTGRTWKGTAFG 321
Query: 556 GFKSRDSVPKLVNDYLDKKIKIDEFVTHEMPLKSINEAFDLMHEGKSLR 702
G+KS +SVPKLV +Y++KK+K+DEFVTH +P + I+E FDLM GKS+R
Sbjct: 322 GYKSVESVPKLVEEYMNKKVKVDEFVTHTLPFEKIHEGFDLMGAGKSIR 370
>sp|P81431|ADHX_OCTVU Alcohol dehydrogenase class III (Glutathione-dependent formaldehyde
dehydrogenase) (FDH)
Length = 378
Score = 293 bits (750), Expect = 4e-79
Identities = 145/230 (63%), Positives = 175/230 (76%)
Frame = +1
Query: 16 GCSTFSEYTVVAEISLAKISKEAPLNRVCLLGCGITTGFGAAINTAKVEPGSICAVWGLG 195
GCSTFSE+TVVAEIS+AK++ +A L++VCLLGCGI+TG+GAA+NTA VE GS CAVWGLG
Sbjct: 144 GCSTFSEFTVVAEISIAKVNPKAALDKVCLLGCGISTGYGAALNTAAVEKGSNCAVWGLG 203
Query: 196 AVGLATIMGCKXXXXXXXXXXXXNTNKFPYAKQFGATECVNPLDYKDKPFQQVIIDMTDG 375
AVGLA MGCK N +KF K+FG TE VNP + K Q+V+ +MTD
Sbjct: 204 AVGLAVAMGCKAAGAARIIGIDINESKFEIGKKFGITEFVNPKKFC-KSVQKVLGEMTDV 262
Query: 376 GCDFTFECVGNVETMRCALEACHKXXXXXXXXXXXXXXKEISTRPFQLVTGRVWKGTAFG 555
G DFTFEC+GNV MR ALE+CHK +EISTRPFQLVTGRVWKGTAFG
Sbjct: 263 GVDFTFECIGNVGVMRAALESCHKGWGTSVIVGVAAHGEEISTRPFQLVTGRVWKGTAFG 322
Query: 556 GFKSRDSVPKLVNDYLDKKIKIDEFVTHEMPLKSINEAFDLMHEGKSLRA 705
GFKSRDSVPKLV+DY++KK+ +DEFV+H++ K INEAFDLMH+G+S+RA
Sbjct: 323 GFKSRDSVPKLVDDYMNKKLLLDEFVSHKLSFKKINEAFDLMHKGESIRA 372
>sp|P28474|ADHX_MOUSE Alcohol dehydrogenase class III (Alcohol dehydrogenase 2)
(Glutathione-dependent formaldehyde dehydrogenase) (FDH)
(FALDH) (Alcohol dehydrogenase-B2) (ADH-B2)
Length = 374
Score = 290 bits (743), Expect = 2e-78
Identities = 141/229 (61%), Positives = 173/229 (75%)
Frame = +1
Query: 16 GCSTFSEYTVVAEISLAKISKEAPLNRVCLLGCGITTGFGAAINTAKVEPGSICAVWGLG 195
G STFSEYTVVA+IS+AKI APL++VCLLGCGI+TG+GAA+NTAKVEPGS CAV+GLG
Sbjct: 142 GTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLG 201
Query: 196 AVGLATIMGCKXXXXXXXXXXXXNTNKFPYAKQFGATECVNPLDYKDKPFQQVIIDMTDG 375
VGLA IMGCK N +KF AK+FGA+EC++P D+ K Q+V+++MTDG
Sbjct: 202 GVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGASECISPQDFS-KSIQEVLVEMTDG 260
Query: 376 GCDFTFECVGNVETMRCALEACHKXXXXXXXXXXXXXXKEISTRPFQLVTGRVWKGTAFG 555
G D++FEC+GNV+ MR ALEA HK +EISTRPFQLVTGR WKGTAFG
Sbjct: 261 GVDYSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFG 320
Query: 556 GFKSRDSVPKLVNDYLDKKIKIDEFVTHEMPLKSINEAFDLMHEGKSLR 702
G+KS +SVPKLV++Y+ KKIK+DEFVT + IN+AFDLMH G S+R
Sbjct: 321 GWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINQAFDLMHSGDSIR 369
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,283,718
Number of Sequences: 369166
Number of extensions: 1737199
Number of successful extensions: 4289
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4034
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4157
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7425705210
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)