Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_K09
(806 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 265 1e-70
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 259 8e-69
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 258 1e-68
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 258 2e-68
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 257 2e-68
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 257 3e-68
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 255 1e-67
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 254 1e-67
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 254 3e-67
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 252 7e-67
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 265 bits (677), Expect = 1e-70
Identities = 130/240 (54%), Positives = 160/240 (66%), Gaps = 1/240 (0%)
Frame = +1
Query: 1 EEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSAT 180
EEF A P R +VF K G VDWRT+G VTPVK+Q QCGSCW+FS T
Sbjct: 78 EEFNAVMKGNIPRRSAPVSVFYPKKETGPQATEVDWRTKGAVTPVKDQGQCGSCWAFSTT 137
Query: 181 GSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIE-KFGIESEDAYPY 357
GSLEGQHF KTG+L S +EQQLVD M++AF+YI+ GI++E AYPY
Sbjct: 138 GSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPY 197
Query: 358 TAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGI 537
A DG+C +D + V +C+G+ +I GSET L A +GPISV IDA++ SFQ Y SG+
Sbjct: 198 EARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGV 257
Query: 538 YNEPDCSSTQLDHGVLVVGYGTEDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATM 717
Y EP CS + LDH VL VGYG+E G ++WLVKNSW T WG GYIKMS++ NN CGIAT+
Sbjct: 258 YYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATV 317
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 259 bits (661), Expect = 8e-69
Identities = 125/224 (55%), Positives = 157/224 (70%), Gaps = 2/224 (0%)
Frame = +1
Query: 49 ISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNLTS 228
+ ++ P ++ +P +VDWR G VT VK+Q CGSCW+FS+TG+LEGQHFRK G L S
Sbjct: 110 VGATYIPPAHV-TVPKSVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVS 168
Query: 229 FSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDGTCLYDKSKVVG 405
SEQ LVD LMDNAF YI + GI++E +YPY D +C ++K+ +
Sbjct: 169 LSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGA 228
Query: 406 SCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDHGVL 585
+ TG+VDIP G E + A AT+GP+SVAIDAS+ SFQLY G+YNEP+C LDHGVL
Sbjct: 229 TDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVL 288
Query: 586 VVGYGT-EDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIAT 714
VVGYGT E G +YWLVKNSWGT WG GYIKM+++ NNQCGIAT
Sbjct: 289 VVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIAT 332
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 258 bits (659), Expect = 1e-68
Identities = 134/243 (55%), Positives = 159/243 (65%), Gaps = 5/243 (2%)
Frame = +1
Query: 1 EEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSAT 180
EEFR + + VF P + LP +VDWR +GYVTPVKNQ+QCGSCW+FSAT
Sbjct: 86 EEFRQMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSAT 144
Query: 181 GSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPY 357
G+LEGQ FRKTG L S SEQ LVD M AF+Y+ E G++SE++YPY
Sbjct: 145 GALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPY 204
Query: 358 TAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGI 537
A D C Y V + TG+ + G E +L A ATVGPISVA+DA + SFQ YKSGI
Sbjct: 205 VAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGI 264
Query: 538 YNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCG 705
Y EPDCSS LDHGVLVVGYG E + S YWLVKNSWG WG +GY+K++KD NN CG
Sbjct: 265 YFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCG 324
Query: 706 IAT 714
IAT
Sbjct: 325 IAT 327
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 258 bits (658), Expect = 2e-68
Identities = 130/211 (61%), Positives = 150/211 (71%), Gaps = 2/211 (0%)
Frame = +1
Query: 88 LPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXX 267
+P +VDW +GYVTPVKNQ QCGSCW+FSATG+LEGQ FRKTG L S SEQ LVD
Sbjct: 1 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQ 60
Query: 268 XXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSE 444
LMDNAF+YI E G++SE++YPY A D +C Y TG+VDIP E
Sbjct: 61 GNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDIP-QRE 119
Query: 445 TSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDHGVLVVGYGTEDGSN-Y 621
+L A ATVGPISVAIDA + SFQ YKSGIY +PDCSS LDHGVLVVGYG E +N +
Sbjct: 120 KALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKF 179
Query: 622 WLVKNSWGTVWGIDGYIKMSKDANNQCGIAT 714
W+VKNSWG WG GY+KM+KD NN CGIAT
Sbjct: 180 WIVKNSWGPEWGNKGYVKMAKDQNNHCGIAT 210
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 257 bits (657), Expect = 2e-68
Identities = 137/243 (56%), Positives = 162/243 (66%), Gaps = 5/243 (2%)
Frame = +1
Query: 1 EEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSAT 180
EEFR + K +F P M ++P TVDWR +G VTPVKNQ QCGSCW+FSA+
Sbjct: 86 EEFRQIVNGYRHQKHKKGRLFQEPL-MLQIPKTVDWREKGCVTPVKNQGQCGSCWAFSAS 144
Query: 181 GSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPY 357
G LEGQ F KTG L S SEQ LVD LMD AF+YI E G++SE++YPY
Sbjct: 145 GCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPY 204
Query: 358 TAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGI 537
A+DG+C Y V + TG+VDIP E +L A ATVGPISVA+DAS+ S Q Y SGI
Sbjct: 205 EAKDGSCKYRAEYAVANDTGFVDIP-QQEKALMKAVATVGPISVAMDASHPSLQFYSSGI 263
Query: 538 YNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCG 705
Y EP+CSS LDHGVLVVGYG E + YWLVKNSWG WG+DGYIK++KD NN CG
Sbjct: 264 YYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCG 323
Query: 706 IAT 714
+AT
Sbjct: 324 LAT 326
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 257 bits (656), Expect = 3e-68
Identities = 133/243 (54%), Positives = 161/243 (66%), Gaps = 5/243 (2%)
Frame = +1
Query: 1 EEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSAT 180
EEFR + K +F P ++P +VDWR +GYVTPVKNQ QCGSCW+FSAT
Sbjct: 86 EEFRQVMNGFQNQKHKKGKMFQEPL-FAEIPKSVDWREKGYVTPVKNQGQCGSCWAFSAT 144
Query: 181 GSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPY 357
G+LEGQ FRKTG L S SEQ LVD LMDNAF Y+ + G++SE++YPY
Sbjct: 145 GALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPY 204
Query: 358 TAED-GTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSG 534
D TC Y + TG+VD+P E +L A AT+GPISVAIDA + SFQ YKSG
Sbjct: 205 LGRDTETCNYKPECSAANDTGFVDLP-QREKALMKAVATLGPISVAIDAGHQSFQFYKSG 263
Query: 535 IYNEPDCSSTQLDHGVLVVGY---GTEDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCG 705
IY +PDCSS LDHGVLVVGY GT+ + +W+VKNSWG WG +GY+KM+KD NN CG
Sbjct: 264 IYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCG 323
Query: 706 IAT 714
IAT
Sbjct: 324 IAT 326
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 255 bits (651), Expect = 1e-67
Identities = 125/220 (56%), Positives = 156/220 (70%), Gaps = 2/220 (0%)
Frame = +1
Query: 61 FMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSEQ 240
F++P ++ LP +VDWRT+G VT VK+Q CGSCW+FS+TG+LEGQHFRK+G L S SEQ
Sbjct: 116 FISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQ 174
Query: 241 QLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDGTCLYDKSKVVGSCTG 417
LVD LMDNAF YI + GI++E +YPY A D +C ++K V + G
Sbjct: 175 NLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRG 234
Query: 418 YVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDHGVLVVGY 597
+ DIP G E +A A ATVGP+SVAIDAS+ SFQ Y G+YNEP C + LDHGVLVVG+
Sbjct: 235 FTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGF 294
Query: 598 GT-EDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIAT 714
GT E G +YWLVKNSWGT WG G+IKM ++ NQCGIA+
Sbjct: 295 GTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIAS 334
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 254 bits (650), Expect = 1e-67
Identities = 133/243 (54%), Positives = 160/243 (65%), Gaps = 5/243 (2%)
Frame = +1
Query: 1 EEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSAT 180
EEFR + + VF P + P +VDWR +GYVTPVKNQ QCGSCW+FSAT
Sbjct: 86 EEFRQVMNGFQNRKPRKGKVFQEPL-FYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSAT 144
Query: 181 GSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPY 357
G+LEGQ FRKTG L S SEQ LVD LMD AF+Y+ + G++SE++YPY
Sbjct: 145 GALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPY 204
Query: 358 TAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGI 537
A + +C Y+ V + TG+VDIP E +L A ATVGPISVAIDA + SF YK GI
Sbjct: 205 EATEESCKYNPKYSVANDTGFVDIP-KQEKALMKAVATVGPISVAIDAGHESFLFYKEGI 263
Query: 538 YNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCG 705
Y EPDCSS +DHGVLVVGYG E D + YWLVKNSWG WG+ GY+KM+KD N CG
Sbjct: 264 YFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCG 323
Query: 706 IAT 714
IA+
Sbjct: 324 IAS 326
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 254 bits (648), Expect = 3e-67
Identities = 134/243 (55%), Positives = 164/243 (67%), Gaps = 5/243 (2%)
Frame = +1
Query: 1 EEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSAT 180
EEFR + K +F P M K+P +VDWR +G VTPVKNQ QCGSCW+FSA+
Sbjct: 86 EEFRQVVNGYRHQKHKKGRLFQEPL-MLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSAS 144
Query: 181 GSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPY 357
G LEGQ F KTG L S SEQ LVD LMD AF+YI E G++SE++YPY
Sbjct: 145 GCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPY 204
Query: 358 TAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGI 537
A+DG+C Y V + TG+VDIP E +L A ATVGPISVA+DAS+ S Q Y SGI
Sbjct: 205 EAKDGSCKYRAEFAVANDTGFVDIP-QQEKALMKAVATVGPISVAMDASHPSLQFYSSGI 263
Query: 538 YNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCG 705
Y EP+CSS LDHGVL+VGYG E + + YWLVKNSWG+ WG++GYIK++KD +N CG
Sbjct: 264 YYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCG 323
Query: 706 IAT 714
+AT
Sbjct: 324 LAT 326
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 252 bits (644), Expect = 7e-67
Identities = 134/244 (54%), Positives = 161/244 (65%), Gaps = 6/244 (2%)
Frame = +1
Query: 1 EEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSAT 180
EEFR + K +F P + +P +VDW +GYVTPVKNQ QCGSCW+FSAT
Sbjct: 86 EEFRQVMNGFQNQKHKKGKLFHEPL-LVDVPKSVDWTKKGYVTPVKNQGQCGSCWAFSAT 144
Query: 181 GSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPY 357
G+LEGQ FRKTG L S SEQ LVD LMDNAF+YI + G++SE++YPY
Sbjct: 145 GALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPY 204
Query: 358 TAED-GTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSG 534
A D +C Y + TG+VDIP E +L A ATVGPISVAIDA + SFQ YKSG
Sbjct: 205 LATDTNSCNYKPECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHTSFQFYKSG 263
Query: 535 IYNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQC 702
IY +PDCS LDHGVLVVGYG E + + +W+VKNSWG WG +GY+KM+KD NN C
Sbjct: 264 IYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHC 323
Query: 703 GIAT 714
GIAT
Sbjct: 324 GIAT 327
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.317 0.133 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,153,447
Number of Sequences: 369166
Number of extensions: 1913545
Number of successful extensions: 6173
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5523
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5762
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7666799535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)