Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_I18
(855 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 120 4e-27
sp|Q12236|KOK0_YEAST Probable serine/threonine-protein kina... 120 5e-27
sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 119 8e-27
sp|Q13233|M3K1_HUMAN Mitogen-activated protein kinase kinas... 119 1e-26
sp|P53349|M3K1_MOUSE Mitogen-activated protein kinase kinas... 118 2e-26
sp|Q9Y7J6|KOIA_SCHPO Putative serine/threonine-protein kina... 118 2e-26
sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinas... 117 5e-26
sp|Q62925|M3K1_RAT Mitogen-activated protein kinase kinase ... 116 7e-26
sp|P27636|CDC15_YEAST Cell division control protein 15 114 3e-25
sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinas... 114 3e-25
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 120 bits (302), Expect = 4e-27
Identities = 70/186 (37%), Positives = 110/186 (59%), Gaps = 2/186 (1%)
Frame = +1
Query: 295 HPRIINLLGFFKD--ELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGLSYL 468
H RI+ G +D E I ME+M GS+ +K ++ E + RK++ QIL+G+SYL
Sbjct: 421 HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL 480
Query: 469 HKNRVIHCDLKSSNILLDNNLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPE 648
H N ++H D+K +NIL D+ ++K+ F SK L + MS M+S GT +M+PE
Sbjct: 481 HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL---QTICMSGTGMRSVTGTPYWMSPE 537
Query: 649 VLIDQKITRKSDVWSFGAVLVELVTGRQPFYGLESINIILKIADEQTIDYVpreGMSDHL 828
V+ + RK+DVWS G +VE++T + P+ E++ I KIA + T +P +S+H
Sbjct: 538 VISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSH-ISEHG 596
Query: 829 RDFIAK 846
RDF+ +
Sbjct: 597 RDFLRR 602
>sp|Q12236|KOK0_YEAST Probable serine/threonine-protein kinase YOL100W
Length = 1081
Score = 120 bits (301), Expect = 5e-27
Identities = 65/219 (29%), Positives = 111/219 (50%), Gaps = 5/219 (2%)
Frame = +1
Query: 211 ILMKRYTVAEQSYKPVLRELVSFAKLDDHPRIINLLGFFKDELYFYIAMEHMERGSLHFY 390
+L K Y + ++ K V E + KL++ P ++ L F+DE Y +E+ G
Sbjct: 209 VLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSL 268
Query: 391 IKNNSSINEDLIRKWSLQILQGLSYLHKNRVIHCDLKSSNILLDNNLDIKISGFSLSKYL 570
+K S++E R ++ QI+ + YLH N +IH D+K NILLD + IK++ F +K L
Sbjct: 269 MKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLL 328
Query: 571 AGANSTVMSEGF-----MQSKPGTCNFMAPEVLIDQKITRKSDVWSFGAVLVELVTGRQP 735
N++V + +S GT +++PE+L D + D+W+FG +L +++ G+ P
Sbjct: 329 NPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKPP 388
Query: 736 FYGLESINIILKIADEQTIDYVpreGMSDHLRDFIAKCL 852
F ++ N L + Y G +RD + K L
Sbjct: 389 F---KATNEYLTFQKVMKVQYAFTPGFPLIIRDLVKKIL 424
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 119 bits (299), Expect = 8e-27
Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 2/186 (1%)
Frame = +1
Query: 295 HPRIINLLGFFKD--ELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGLSYL 468
H RI+ G +D E I ME+M GS+ +K ++ E + RK++ QIL+G+SYL
Sbjct: 421 HERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL 480
Query: 469 HKNRVIHCDLKSSNILLDNNLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPE 648
H N ++H D+K +NIL D+ ++K+ F SK L + MS ++S GT +M+PE
Sbjct: 481 HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL---QTICMSGTGIRSVTGTPYWMSPE 537
Query: 649 VLIDQKITRKSDVWSFGAVLVELVTGRQPFYGLESINIILKIADEQTIDYVpreGMSDHL 828
V+ + RK+DVWS G +VE++T + P+ E++ I KIA + T +P +S+H
Sbjct: 538 VISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSH-ISEHG 596
Query: 829 RDFIAK 846
RDF+ +
Sbjct: 597 RDFLRR 602
>sp|Q13233|M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 (MAPK/ERK kinase
kinase 1) (MEK kinase 1) (MEKK 1)
Length = 1495
Score = 119 bits (297), Expect = 1e-26
Identities = 78/244 (31%), Positives = 128/244 (52%), Gaps = 10/244 (4%)
Frame = +1
Query: 151 VAVGQFSQVYTARIVGNETVILMKRYTVA------EQSYKPVLRELVSFAKLDDHPRIIN 312
+ +G FS Y A+ VG T++ +K+ T ++ LRE + +HP II
Sbjct: 1232 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 1291
Query: 313 LLGFFKDELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGLSYLHKNRVIHC 492
+LG ++ + + +E M GS+ + + E ++ ++ Q+L+GLSYLH+N++IH
Sbjct: 1292 MLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHR 1351
Query: 493 DLKSSNILLDN-NLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPEVLIDQKI 669
D+K +N+L+D+ ++I+ F + LA + T E F GT FMAPEVL Q+
Sbjct: 1352 DVKGANLLIDSTGQRLRIADFGAAARLA-SKGTGAGE-FQGQLLGTIAFMAPEVLRGQQY 1409
Query: 670 TRKSDVWSFGAVLVELVTGRQPFYGLESIN---IILKIADEQTIDYVpreGMSDHLRDFI 840
R DVWS G ++E+ + P+ + N +I KIA T +P +S LRD
Sbjct: 1410 GRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSH-LSPGLRDVA 1468
Query: 841 AKCL 852
+CL
Sbjct: 1469 LRCL 1472
>sp|P53349|M3K1_MOUSE Mitogen-activated protein kinase kinase kinase 1 (MAPK/ERK kinase
kinase 1) (MEK kinase 1) (MEKK 1)
Length = 1493
Score = 118 bits (296), Expect = 2e-26
Identities = 78/244 (31%), Positives = 128/244 (52%), Gaps = 10/244 (4%)
Frame = +1
Query: 151 VAVGQFSQVYTARIVGNETVILMKRYTVA------EQSYKPVLRELVSFAKLDDHPRIIN 312
+ +G FS Y A+ VG T++ +K+ T ++ LRE + +HP II
Sbjct: 1230 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMGHLNHPNIIR 1289
Query: 313 LLGFFKDELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGLSYLHKNRVIHC 492
+LG ++ + + +E M GS+ + + E ++ ++ Q+L+GLSYLH+N++IH
Sbjct: 1290 MLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHR 1349
Query: 493 DLKSSNILLDN-NLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPEVLIDQKI 669
D+K +N+L+D+ ++I+ F + LA + T E F GT FMAPEVL Q+
Sbjct: 1350 DVKGANLLIDSTGQRLRIADFGAAARLA-SKGTGAGE-FQGQLLGTIAFMAPEVLRGQQY 1407
Query: 670 TRKSDVWSFGAVLVELVTGRQPFYGLESIN---IILKIADEQTIDYVpreGMSDHLRDFI 840
R DVWS G ++E+ + P+ + N +I KIA T +P +S LRD
Sbjct: 1408 GRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSH-LSPGLRDVA 1466
Query: 841 AKCL 852
+CL
Sbjct: 1467 VRCL 1470
>sp|Q9Y7J6|KOIA_SCHPO Putative serine/threonine-protein kinase C1778.10c
Length = 550
Score = 118 bits (295), Expect = 2e-26
Identities = 66/193 (34%), Positives = 103/193 (53%), Gaps = 5/193 (2%)
Frame = +1
Query: 211 ILMKRYTVAEQSYKPVLRELVSFAKLDDHPRIINLLGFFKDELYFYIAMEHMERGSLHFY 390
+L K+Y V E K V E S +L+ P I L F+D+L Y +E G L Y
Sbjct: 84 VLDKKYIVKENKVKYVNIERDSMMRLNGFPGISRLFHTFQDDLKLYYVLELAPNGELLQY 143
Query: 391 IKNNSSINEDLIRKWSLQILQGLSYLHKNRVIHCDLKSSNILLDNNLDIKISGFSLS--- 561
IK ++E+ +R ++ +IL + Y+H +IH DLK NIL D N+ +KI+ F +
Sbjct: 144 IKKYRFLDENCVRFYAAEILSSIEYMHSCGIIHRDLKPENILFDGNMHVKITDFGTAKIL 203
Query: 562 --KYLAGANSTVMSEGFMQSKPGTCNFMAPEVLIDQKITRKSDVWSFGAVLVELVTGRQP 735
KY+ + T F+ GT ++APE+L Q +++ SD+W+F V+ +++ G P
Sbjct: 204 PPKYVNSPDYTTFPSSFV----GTAEYVAPELLSRQVVSKSSDLWAFACVVYQMIVGSPP 259
Query: 736 FYGLESINIILKI 774
F+G NI KI
Sbjct: 260 FHGSNPNNIFKKI 272
>sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase
kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis
signal-regulating kinase 1) (ASK-1)
Length = 1374
Score = 117 bits (292), Expect = 5e-26
Identities = 79/250 (31%), Positives = 125/250 (50%), Gaps = 9/250 (3%)
Frame = +1
Query: 127 ELIEGNNHVAVGQ--FSQVYTARIVGNETVILMKRYTVAEQSYKPVLRELVSFAKLDDHP 300
E E + V +G+ + VY R + N+ I +K + Y L E ++ K H
Sbjct: 676 EYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHK 735
Query: 301 RIINLLGFFKDELYFYIAMEHMERGSLHFYIKNN---SSINEDLIRKWSLQILQGLSYLH 471
I+ LG F + + I ME + GSL +++ NE I ++ QIL+GL YLH
Sbjct: 736 NIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLH 795
Query: 472 KNRVIHCDLKSSNILLDNNLDI-KISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPE 648
N+++H D+K N+L++ + KIS F SK LAG N ++ GT +MAPE
Sbjct: 796 DNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCT------ETFTGTLQYMAPE 849
Query: 649 VLI--DQKITRKSDVWSFGAVLVELVTGRQPFYGL-ESINIILKIADEQTIDYVpreGMS 819
++ + + +D+WS G ++E+ TG+ PFY L E + K+ + +P E MS
Sbjct: 850 IIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIP-ESMS 908
Query: 820 DHLRDFIAKC 849
+ FI KC
Sbjct: 909 AEAKAFILKC 918
>sp|Q62925|M3K1_RAT Mitogen-activated protein kinase kinase kinase 1 (MAPK/ERK kinase
kinase 1) (MEK kinase 1) (MEKK 1)
Length = 1493
Score = 116 bits (291), Expect = 7e-26
Identities = 77/244 (31%), Positives = 127/244 (52%), Gaps = 10/244 (4%)
Frame = +1
Query: 151 VAVGQFSQVYTARIVGNETVILMKRYTVA------EQSYKPVLRELVSFAKLDDHPRIIN 312
+ +G FS Y A+ VG T++ +K+ T ++ LRE + +HP II
Sbjct: 1230 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 1289
Query: 313 LLGFFKDELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGLSYLHKNRVIHC 492
+LG ++ + + +E M S+ + + E ++ ++ Q+L+GLSYLH+N++IH
Sbjct: 1290 MLGATCEKSNYNLFIEWMAGASVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHR 1349
Query: 493 DLKSSNILLDN-NLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPEVLIDQKI 669
D+K +N+L+D+ ++I+ F + LA + T E F GT FMAPEVL Q+
Sbjct: 1350 DVKGANLLIDSTGQRLRIADFGAAARLA-SKGTGAGE-FQGQLLGTIAFMAPEVLRGQQY 1407
Query: 670 TRKSDVWSFGAVLVELVTGRQPFYGLESIN---IILKIADEQTIDYVpreGMSDHLRDFI 840
R DVWS G ++E+ + P+ + N +I KIA T +P +S LRD
Sbjct: 1408 GRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSH-LSPGLRDVA 1466
Query: 841 AKCL 852
+CL
Sbjct: 1467 LRCL 1470
>sp|P27636|CDC15_YEAST Cell division control protein 15
Length = 974
Score = 114 bits (286), Expect = 3e-25
Identities = 70/231 (30%), Positives = 117/231 (50%), Gaps = 1/231 (0%)
Frame = +1
Query: 160 GQFSQVYTARIVGNETVILMKRYTVAEQSYKPVLRELVSFAKLDDHPRIINLLGFFKDEL 339
G + VY A + V+ +K + +S K +H I+ GF +
Sbjct: 34 GSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSY 93
Query: 340 YFYIAMEHMERGSLHFYIKNNSS-INEDLIRKWSLQILQGLSYLHKNRVIHCDLKSSNIL 516
YI +E+ GSL I +S+ ++E+ + + Q L GL YLH VIH D+K++NIL
Sbjct: 94 ELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANIL 153
Query: 517 LDNNLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPEVLIDQKITRKSDVWSF 696
L + +K++ F +S + + T+ GT N+MAPE+L ++ + SD+WS
Sbjct: 154 LSADNTVKLADFGVSTIVNSSALTLA---------GTLNWMAPEILGNRGASTLSDIWSL 204
Query: 697 GAVLVELVTGRQPFYGLESINIILKIADEQTIDYVpreGMSDHLRDFIAKC 849
GA +VE++T P++ L NI + ++ Y P S+ L+DF++KC
Sbjct: 205 GATVVEMLTKNPPYHNLTDANIYYAVEND---TYYPPSSFSEPLKDFLSKC 252
>sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase
kinase 2) (MEK kinase 2) (MEKK 2)
Length = 618
Score = 114 bits (286), Expect = 3e-25
Identities = 67/186 (36%), Positives = 108/186 (58%), Gaps = 2/186 (1%)
Frame = +1
Query: 295 HPRIINLLGFFKD--ELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGLSYL 468
H RI+ G +D E I ME+M GS+ +K ++ E+ RK++ QIL+G+ YL
Sbjct: 414 HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENGTRKYTRQILEGVHYL 473
Query: 469 HKNRVIHCDLKSSNILLDNNLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPE 648
H N ++H D+K +NIL D+ ++K+ F SK L + +S M+S GT +M+PE
Sbjct: 474 HSNMILHRDIKGANILRDSTGNVKLGDFGASKRL---QTICLSGTGMKSVTGTPYWMSPE 530
Query: 649 VLIDQKITRKSDVWSFGAVLVELVTGRQPFYGLESINIILKIADEQTIDYVpreGMSDHL 828
V+ Q RK+D+WS +VE++T + P+ E++ I KIA + T +P +SD+
Sbjct: 531 VISGQGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPH-VSDYT 589
Query: 829 RDFIAK 846
RDF+ +
Sbjct: 590 RDFLKR 595
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 104,093,266
Number of Sequences: 369166
Number of extensions: 2214725
Number of successful extensions: 9045
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6952
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7316
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8438301375
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)