Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_H11
(841 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 216 6e-56
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 214 2e-55
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 213 4e-55
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 213 7e-55
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 213 7e-55
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 211 3e-54
sp|P55097|CATK_MOUSE Cathepsin K precursor 208 2e-53
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 208 2e-53
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 207 2e-53
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 206 5e-53
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 216 bits (550), Expect = 6e-56
Identities = 124/267 (46%), Positives = 166/267 (62%), Gaps = 16/267 (5%)
Frame = +3
Query: 87 EWQVFKTKFNKNYT-AIDELIRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFSDLTYK 263
EW FK + KNY +E R I+ EN I HN ++ G S L +N+++DL +
Sbjct: 28 EWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHH 87
Query: 264 EFEKL-----YLLSKNIEYND----GIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCG 416
EF +L Y L K + D G+ ++ P ++ LP SVDWRTKG VT VK+QG CG
Sbjct: 88 EFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCG 146
Query: 417 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSH-GI 587
SCWAFS+TG+LEGQHFRK VL ++SEQ LVDC TK N+GCNGG M+ AF YI + GI
Sbjct: 147 SCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGI 206
Query: 588 ESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDV---G 758
++E +YPY+A +C F+K V A +GF +I +EK +A AVATVGP+SVAID
Sbjct: 207 DTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHES 266
Query: 759 YSFHIQQVFTMKLNVILHTNHAVLVVG 839
+ F+ + V+ + +H VLVVG
Sbjct: 267 FQFYSEGVYNEPQCDAQNLDHGVLVVG 293
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 214 bits (545), Expect = 2e-55
Identities = 105/256 (41%), Positives = 162/256 (63%), Gaps = 6/256 (2%)
Frame = +3
Query: 90 WQVFKTKFNKNYTAIDELIRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFSDLTYKEF 269
W +K +NK Y D+ R+ IW +N+K+IQ HN+++DLG +++LG+N+F+D+T++EF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 270 EKLYLLSKNIEYNDGIDYLPPLNIDN--LPDSVDWRTKGYVTNVKNQGQCGSCWAFSTTG 443
+ YL + +D + + P +N +PD +DWR GYVT VK+QG CGSCWAFSTTG
Sbjct: 81 KAKYLTEMS-RASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTG 139
Query: 444 SLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSHGIESEDNYPYQA 617
++EGQ+ + + + SEQQLVDC N+GC+GG M A++Y+ G+E+E +YPY A
Sbjct: 140 TMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTA 199
Query: 618 KQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGYSFHIQQ--VFTM 791
+G C ++K VA G+ ++S +E +L V P +VA+DV F + + ++
Sbjct: 200 VEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVDVESDFMMYRSGIYQS 259
Query: 792 KLNVILHTNHAVLVVG 839
+ L NHAVL VG
Sbjct: 260 QTCSPLRVNHAVLAVG 275
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 213 bits (543), Expect = 4e-55
Identities = 116/271 (42%), Positives = 169/271 (62%), Gaps = 9/271 (3%)
Frame = +3
Query: 54 SNLIINEEFNAEWQVFKTKFNKNYTA-IDELIRKTIWIENIKYIQHHNVKYDLGHHSHSL 230
S L E + +W+++K + K Y + +DE+ R+ IW +N+K+I HN++ LG H++ L
Sbjct: 15 SALYPEEILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYEL 74
Query: 231 GINEFSDLTYKEFEK----LYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVK 398
+N D+T +E + L + + ND + Y+P PDS+D+R KGYVT VK
Sbjct: 75 AMNHLGDMTSEEVVQKMTGLKVPPSHSRSNDTL-YIPDWE-GRTPDSIDYRKKGYVTPVK 132
Query: 399 NQGQCGSCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYI-S 575
NQGQCGSCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+
Sbjct: 133 NQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQK 192
Query: 576 SHGIESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAID- 752
+ GI+SED YPY + NC+++ + A C+G++ I NEK L AVA VGP+SVAID
Sbjct: 193 NRGIDSEDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDA 252
Query: 753 --VGYSFHIQQVFTMKLNVILHTNHAVLVVG 839
+ F+ + V+ + + NHAVL VG
Sbjct: 253 SLTSFQFYSKGVYYDENCNSDNLNHAVLAVG 283
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 213 bits (541), Expect = 7e-55
Identities = 115/264 (43%), Positives = 166/264 (62%), Gaps = 8/264 (3%)
Frame = +3
Query: 72 EEFNAEWQVFKTKFNKNYT-AIDELIRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 248
E + W+++K K Y +DE+ R+ IW +N+KYI HN++ LG H++ L +N
Sbjct: 20 EILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLG 79
Query: 249 DLTYKEF-EKLYLLSKNIEYNDGID--YLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGS 419
D+T +E +K+ L + ++ D Y+P PDSVD+R KGYVT VKNQGQCGS
Sbjct: 80 DMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWE-GRAPDSVDYRKKGYVTPVKNQGQCGS 138
Query: 420 CWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYI-SSHGIESE 596
CWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+SE
Sbjct: 139 CWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSE 198
Query: 597 DNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAID---VGYSF 767
D YPY ++ +C+++ + A C+G++ I NEK L AVA VGP+SVAID + F
Sbjct: 199 DAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQF 258
Query: 768 HIQQVFTMKLNVILHTNHAVLVVG 839
+ + V+ + + NHAVL VG
Sbjct: 259 YSKGVYYDESCNSDNLNHAVLAVG 282
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 213 bits (541), Expect = 7e-55
Identities = 115/265 (43%), Positives = 167/265 (63%), Gaps = 9/265 (3%)
Frame = +3
Query: 72 EEFNAEWQVFKTKFNKNYTA-IDELIRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 248
E + W+++K K Y + +DE+ R+ IW +N+KYI HN++ LG H++ L +N
Sbjct: 20 EILDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLG 79
Query: 249 DLTYKEFEK----LYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCG 416
D+T +E + L + + + ND + Y+P PDSVD+R KGYVT VKNQGQCG
Sbjct: 80 DMTNEEVVQKMTGLKVPASHSRSNDTL-YIPDWE-GRAPDSVDYRKKGYVTPVKNQGQCG 137
Query: 417 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYI-SSHGIES 593
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+S
Sbjct: 138 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDS 197
Query: 594 EDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAID---VGYS 764
ED YPY ++ +C+++ + A C+G++ I NEK L AVA VGP+SVAID +
Sbjct: 198 EDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 765 FHIQQVFTMKLNVILHTNHAVLVVG 839
F+ + V+ + + NHAVL VG
Sbjct: 258 FYSKGVYYDESCNSDNLNHAVLAVG 282
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 211 bits (536), Expect = 3e-54
Identities = 113/265 (42%), Positives = 167/265 (63%), Gaps = 9/265 (3%)
Frame = +3
Query: 72 EEFNAEWQVFKTKFNKNYTA-IDELIRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 248
E + +W+++K ++K Y + +DE+ R+ IW +N+K+I HN++ LG H++ L +N
Sbjct: 20 EILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLG 79
Query: 249 DLTYKEFEK----LYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCG 416
D+T +E + L + ND + Y+P PDS+D+R KGYVT VKNQGQCG
Sbjct: 80 DMTSEEVVQKMTGLKVPPSRSHSNDTL-YIPDWE-GRTPDSIDYRKKGYVTPVKNQGQCG 137
Query: 417 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYIS-SHGIES 593
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++N GC GG+M AF+Y+ + GI+S
Sbjct: 138 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGGYMTNAFQYVQRNRGIDS 197
Query: 594 EDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAID---VGYS 764
ED YPY + +C+++ + A C+G++ I NEK L AVA VGP+SVAID +
Sbjct: 198 EDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 765 FHIQQVFTMKLNVILHTNHAVLVVG 839
F+ + V+ + + NHAVL VG
Sbjct: 258 FYSKGVYYDENCSSDNVNHAVLAVG 282
>sp|P55097|CATK_MOUSE Cathepsin K precursor
Length = 329
Score = 208 bits (529), Expect = 2e-53
Identities = 112/264 (42%), Positives = 164/264 (62%), Gaps = 8/264 (3%)
Frame = +3
Query: 72 EEFNAEWQVFKTKFNKNYTA-IDELIRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 248
E + +W+++K K Y + +DE+ R+ IW +N+K I HN++ LG H++ L +N
Sbjct: 20 EMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLG 79
Query: 249 DLTYKEFEKLYL---LSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGS 419
D+T +E + + + Y++ Y P +PDS+D+R KGYVT VKNQGQCGS
Sbjct: 80 DMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWE-GRVPDSIDYRKKGYVTPVKNQGQCGS 138
Query: 420 CWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTKNSGCNGGWMNIAFEYISSH-GIESE 596
CWAFS+ G+LEGQ +K L +S Q LVDCVT+N GC GG+M AF+Y+ + GI+SE
Sbjct: 139 CWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTENYGCGGGYMTTAFQYVQQNGGIDSE 198
Query: 597 DNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAID---VGYSF 767
D YPY + +C+++ + A C+G++ I NEK L AVA VGPISV+ID + F
Sbjct: 199 DAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQF 258
Query: 768 HIQQVFTMKLNVILHTNHAVLVVG 839
+ + V+ + + NHAVLVVG
Sbjct: 259 YSRGVYYDENCDRDNVNHAVLVVG 282
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 208 bits (529), Expect = 2e-53
Identities = 115/263 (43%), Positives = 160/263 (60%), Gaps = 6/263 (2%)
Frame = +3
Query: 69 NEEFNAEWQVFKTKFNKNYTAIDELIRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFS 248
++ + +W +K + Y A +E R+ +W +N+K I+ HN +Y G H ++ +N F
Sbjct: 22 DQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFG 81
Query: 249 DLTYKEFEKLYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGSCWA 428
D+T +EF ++ +N ++ G + PL +D LP SVDWR KGYVT VKNQ QCGSCWA
Sbjct: 82 DMTNEEFRQMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWA 140
Query: 429 FSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYISSH-GIESED 599
FS TG+LEGQ FRK L ++SEQ LVDC N GCNGG+M AF+Y+ + G++SE+
Sbjct: 141 FSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEE 200
Query: 600 NYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGYS---FH 770
+YPY A C + VAN GF + EK L AVATVGPISVA+D G+S F+
Sbjct: 201 SYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFY 260
Query: 771 IQQVFTMKLNVILHTNHAVLVVG 839
++ + +H VLVVG
Sbjct: 261 KSGIYFEPDCSSKNLDHGVLVVG 283
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 207 bits (528), Expect = 2e-53
Identities = 118/268 (44%), Positives = 164/268 (61%), Gaps = 6/268 (2%)
Frame = +3
Query: 54 SNLIINEEFNAEWQVFKTKFNKNYTAIDELIRKTIWIENIKYIQHHNVKYDLGHHSHSLG 233
+ L + A+W +K N+ Y +E R+ +W +N+K I+ HN +Y G HS ++
Sbjct: 17 ATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMA 76
Query: 234 INEFSDLTYKEFEKLYLLSKNIEYNDGIDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQC 413
+N F D+T +EF ++ +N + G + PL + P SVDWR KGYVT VKNQGQC
Sbjct: 77 MNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYE-APRSVDWREKGYVTPVKNQGQC 135
Query: 414 GSCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDC--VTKNSGCNGGWMNIAFEYISSH-G 584
GSCWAFS TG+LEGQ FRK L ++SEQ LVDC N GCNGG M+ AF+Y+ + G
Sbjct: 136 GSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGG 195
Query: 585 IESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGYS 764
++SE++YPY+A + +C ++ VAN GF +I EK L AVATVGPISVAID G+
Sbjct: 196 LDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHE 254
Query: 765 ---FHIQQVFTMKLNVILHTNHAVLVVG 839
F+ + ++ +H VLVVG
Sbjct: 255 SFLFYKEGIYFEPDCSSEDMDHGVLVVG 282
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 206 bits (525), Expect = 5e-53
Identities = 117/259 (45%), Positives = 157/259 (60%), Gaps = 9/259 (3%)
Frame = +3
Query: 90 WQVFKTKFNKNYT-AIDELIRKTIWIENIKYIQHHNVKYDLGHHSHSLGINEFSDLTYKE 266
W+ FK K+ + Y A ++ R+ I+ +N KYI+ N KY+ G + +L +N+F D+T +E
Sbjct: 20 WEHFKGKYGRQYVDAEEDSYRRVIFEQNQKYIEEFNKKYENGEVTFNLAMNKFGDMTLEE 79
Query: 267 FEKLYLLSKNIEYNDG--IDYLPPLNIDNLPDSVDWRTKGYVTNVKNQGQCGSCWAFSTT 440
F + + NI + P VDWRTKG VT VK+QGQCGSCWAFSTT
Sbjct: 80 FNAV--MKGNIPRRSAPVSVFYPKKETGPQATEVDWRTKGAVTPVKDQGQCGSCWAFSTT 137
Query: 441 GSLEGQHFRKHKVLQNISEQQLVDCVTK--NSGCNGGWMNIAFEYI-SSHGIESEDNYPY 611
GSLEGQHF K L +++EQQLVDC GCNGGWMN AF+YI +++GI++E YPY
Sbjct: 138 GSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPY 197
Query: 612 QAKQGNCVFDKSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGYS---FHIQQV 782
+A+ G+C FD + V A C G NI S +E L AV +GPISV ID +S F+ V
Sbjct: 198 EARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGV 257
Query: 783 FTMKLNVILHTNHAVLVVG 839
+ + +HAVL VG
Sbjct: 258 YYEPSCSPSYLDHAVLAVG 276
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,484,800
Number of Sequences: 369166
Number of extensions: 1949254
Number of successful extensions: 6187
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5513
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5775
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8197207050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)