Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_G11
(721 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 270 2e-72
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 270 3e-72
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 269 5e-72
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 268 1e-71
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 266 5e-71
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 266 5e-71
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 262 8e-70
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 261 1e-69
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 258 1e-68
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 257 3e-68
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 270 bits (691), Expect = 2e-72
Identities = 134/218 (61%), Positives = 154/218 (70%), Gaps = 2/218 (0%)
Frame = +2
Query: 5 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 184
+P SVDW +KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVD S
Sbjct: 1 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQ 60
Query: 185 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNE 361
LMDNAF+YIK+ G++SE YPY ATD +C P K TGF DI Q E
Sbjct: 61 GNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDI-PQRE 119
Query: 362 TDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKY 538
L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+
Sbjct: 120 KALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKF 179
Query: 539 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 652
WIVKNSW WG GY+KM+KD+ N CGIAT ASYP V
Sbjct: 180 WIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 270 bits (690), Expect = 3e-72
Identities = 134/220 (60%), Positives = 154/220 (70%), Gaps = 5/220 (2%)
Frame = +2
Query: 8 PASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXX 187
P SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK RLIS SEQ LVDCS
Sbjct: 115 PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQG 174
Query: 188 XXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNET 364
LMD AF+Y++D G++SE YPY AT+ +CK NP V TGF DI Q E
Sbjct: 175 NEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EK 233
Query: 365 DLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQI----GK 532
L AVATVGP+SVAIDAGH SF YK GIY E CS+ +DHGVL VGYG +
Sbjct: 234 ALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNN 293
Query: 533 KYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 652
KYW+VKNSW WG GY+KM+KD++N CGIA+ ASYP V
Sbjct: 294 KYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 269 bits (688), Expect = 5e-72
Identities = 131/221 (59%), Positives = 152/221 (68%), Gaps = 5/221 (2%)
Frame = +2
Query: 5 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 184
LP SVDWR+KGYVTPVKNQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 114 LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQ 173
Query: 185 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNE 361
M AF+Y+K+ G++SE YPY A D CK P V TGFT + E
Sbjct: 174 GNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKE 233
Query: 362 TDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG----TQIG 529
L AVATVGP+SVA+DAGH+SFQ YKSGIY E CS+ LDHGVL VGYG
Sbjct: 234 KALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNN 293
Query: 530 KKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 652
KYW+VKNSW WG +GY+K++KDK N CGIAT ASYP V
Sbjct: 294 SKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 268 bits (684), Expect = 1e-71
Identities = 134/221 (60%), Positives = 153/221 (69%), Gaps = 5/221 (2%)
Frame = +2
Query: 5 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 184
+P SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 114 IPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQ 173
Query: 185 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQN 358
LMDNAFRY+KD G++SE YPY D TC P TGF D+ Q
Sbjct: 174 GNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDL-PQR 232
Query: 359 ETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIG 529
E L AVAT+GP+SVAIDAGH SFQ YKSGIY + CS+ LDHGVL VGY GT
Sbjct: 233 EKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSN 292
Query: 530 KKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 652
K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 293 NKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 266 bits (679), Expect = 5e-71
Identities = 129/218 (59%), Positives = 154/218 (70%), Gaps = 2/218 (0%)
Frame = +2
Query: 5 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 184
LP SVDWR KG VT VK+Q CGSCW+FS+TG+LEGQ+FRK+ L+S SEQ LVDCS
Sbjct: 124 LPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKY 183
Query: 185 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNE 361
LMDNAFRYIKD GI++E YPY A D +C N + GFTDI +E
Sbjct: 184 GNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDE 243
Query: 362 TDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKY 538
+A AVATVGPVSVAIDA H SFQ Y G+YNE C LDHGVL VG+GT + G+ Y
Sbjct: 244 KKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDY 303
Query: 539 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 652
W+VKNSW TWG+ G+IKM ++K+NQCGIA+ +SYPLV
Sbjct: 304 WLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 266 bits (679), Expect = 5e-71
Identities = 135/222 (60%), Positives = 153/222 (68%), Gaps = 6/222 (2%)
Frame = +2
Query: 5 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 184
+P SVDW +KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 114 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQ 173
Query: 185 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQN 358
LMDNAF+YIKD G++SE YPY ATD +C P TGF DI Q
Sbjct: 174 GNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDI-PQR 232
Query: 359 ETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----I 526
E L AVATVGP+SVAIDAGH SFQ YKSGIY + CS LDHGVL VGYG +
Sbjct: 233 EKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSN 292
Query: 527 GKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 652
K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 293 NNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 262 bits (669), Expect = 8e-70
Identities = 128/218 (58%), Positives = 151/218 (69%), Gaps = 2/218 (0%)
Frame = +2
Query: 5 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 184
+P SVDWR+ G VT VK+Q CGSCW+FS+TG+LEGQ+FRK L+S SEQ LVDCS
Sbjct: 122 VPKSVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKY 181
Query: 185 XXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNE 361
LMDNAFRYIKD G I++E YPY D +C N + I TGF DI +E
Sbjct: 182 GNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDE 241
Query: 362 TDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKY 538
+ AVAT+GPVSVAIDA H SFQLY G+YNE C LDHGVL VGYGT + G Y
Sbjct: 242 EKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDY 301
Query: 539 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 652
W+VKNSW TWGE GYIKM++++ NQCGIAT +SYP V
Sbjct: 302 WLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 261 bits (667), Expect = 1e-69
Identities = 122/213 (57%), Positives = 156/213 (73%), Gaps = 1/213 (0%)
Frame = +2
Query: 17 VDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXX 196
VDWR KG VTPVK+Q QCGSCW+FS TGSLEGQ+F K LIS +EQQLVDCS
Sbjct: 111 VDWRTKGAVTPVKDQGQCGSCWAFSTTGSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQG 170
Query: 197 XXXXLMDNAFRYIK-DQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLA 373
M++AF YIK + GI++E YPY A DG+C+ + + + C+G T+I S +ET L
Sbjct: 171 CNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQ 230
Query: 374 NAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKN 553
AV +GP+SV IDA H+SFQ Y SG+Y E SCS + LDH VLAVGYG++ G+ +W+VKN
Sbjct: 231 QAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKN 290
Query: 554 SWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 652
SW +WG++GYIKMS+++ N CGIAT+ASYPLV
Sbjct: 291 SWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 258 bits (659), Expect = 1e-68
Identities = 129/222 (58%), Positives = 153/222 (68%), Gaps = 6/222 (2%)
Frame = +2
Query: 5 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 184
+P SVDWR+KGYVT VKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 114 VPKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQ 173
Query: 185 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQN 358
LMDNAF+Y+KD G+++E YPY + +C P TGF DI Q
Sbjct: 174 GNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDI-PQR 232
Query: 359 ETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----I 526
E L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG +
Sbjct: 233 EKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSN 292
Query: 527 GKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 652
K+WIVKNSW WG +GY+KM+KD+ N CGI+T ASYP V
Sbjct: 293 SSKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 257 bits (656), Expect = 3e-68
Identities = 124/217 (57%), Positives = 155/217 (71%), Gaps = 1/217 (0%)
Frame = +2
Query: 5 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 184
+ A VDWR K VTPVK+Q+QCGSCW+FSATG+LEGQ+F KN+ L+S SEQQLVDCS
Sbjct: 106 MAADVDWRTKALVTPVKDQEQCGSCWAFSATGALEGQHFLKNDELVSLSEQQLVDCSTDY 165
Query: 185 XXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNE 361
M +AF YIKD G I++E YPY A D +C+ + + I CTG ++Q E
Sbjct: 166 GNDGCGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSVEVQHTEE 225
Query: 362 TDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYW 541
L AV+ VGP+SVAIDA H SFQ Y SG+Y E++CS T LDHGVLAVGYGT+ K YW
Sbjct: 226 A-LQEAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYW 284
Query: 542 IVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 652
+VKNSW +WG++GYIKMS+++ N CGIA+ SYP V
Sbjct: 285 LVKNSWGSSWGDAGYIKMSRNRDNNCGIASEPSYPTV 321
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,636,521
Number of Sequences: 369166
Number of extensions: 1502102
Number of successful extensions: 4816
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4199
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4337
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6413660220
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)