Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_F13
(846 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UKB1|FBW1B_HUMAN F-box/WD-repeat protein 11 (F-box/WD-... 130 5e-30
sp|Q9Y297|FBW1A_HUMAN F-box/WD-repeat protein 1A (F-box and... 129 8e-30
sp|Q91854|TRCB_XENLA Beta-TrCP (Beta-transducin repeat-cont... 129 8e-30
sp|Q09990|LIN23_CAEEL F-box/WD-repeat protein lin-23 (Abnor... 121 2e-27
sp|Q969H0|FBXW7_HUMAN F-box/WD-repeat protein 7 (F-box and ... 65 2e-10
sp|Q8VBV4|FBXW7_MOUSE F-box/WD-repeat protein 7 (F-box and ... 65 2e-10
sp|Q9VZF4|FBXW7_DROME F-box/WD-repeat protein 7 (F-box and ... 64 4e-10
sp|Q09855|POF11_SCHPO F-box/WD-repeat protein pof11 50 6e-06
sp|Q01277|SCON2_NEUCR Sulfur controller 2 (SCON2) 50 1e-05
sp|Q93794|SEL10_CAEEL F-box/WD-repeat protein sel-10 (Suppr... 48 3e-05
>sp|Q9UKB1|FBW1B_HUMAN F-box/WD-repeat protein 11 (F-box/WD-repeat protein 1B) (F-box and
WD-repeats protein beta-TrCP2)
Length = 542
Score = 130 bits (327), Expect = 5e-30
Identities = 63/87 (72%), Positives = 74/87 (85%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
RFD+K IVSGAYDGKIKVWDL AAL+P++PA++LCL+TL +H+GRVFRLQFDEFQI+SSS
Sbjct: 450 RFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSS 509
Query: 183 HDDTILIWDFLDTGVNQDSGMNMVRSP 263
HDDTILIWDFL+ S N RSP
Sbjct: 510 HDDTILIWDFLNV---PPSAQNETRSP 533
Score = 57.0 bits (136), Expect = 6e-08
Identities = 30/74 (40%), Positives = 43/74 (58%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
++D + I+SG D IK+WD + CL+ LT HTG V LQ+DE IV+ S
Sbjct: 247 QYDDEKIISGLRDNSIKIWDKTSLE---------CLKVLTGHTGSVLCLQYDERVIVTGS 297
Query: 183 HDDTILIWDFLDTG 224
D T+ +WD ++TG
Sbjct: 298 SDSTVRVWD-VNTG 310
Score = 44.3 bits (103), Expect = 4e-04
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Frame = +3
Query: 6 FDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLC--LQTLTQHTGRVFRLQFDEFQIVSS 179
FD KYIVS + D IKVW + S C ++TL H + LQ+ + +VS
Sbjct: 371 FDDKYIVSASGDRTIKVW-----------STSTCEFVRTLNGHKRGIACLQYRDRLVVSG 419
Query: 180 SHDDTILIWD 209
S D+TI +WD
Sbjct: 420 SSDNTIRLWD 429
Score = 42.0 bits (97), Expect = 0.002
Identities = 21/69 (30%), Positives = 36/69 (52%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
++ + +VSG+ D I++WD+ CL+ L H V ++FD +IVS +
Sbjct: 410 QYRDRLVVSGSSDNTIRLWDIECGA---------CLRVLEGHEELVRCIRFDNKRIVSGA 460
Query: 183 HDDTILIWD 209
+D I +WD
Sbjct: 461 YDGKIKVWD 469
Score = 36.2 bits (82), Expect = 0.12
Identities = 22/68 (32%), Positives = 34/68 (50%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
RF + +V+ + D I VWD+ +A + + L H V + FD+ IVS+S
Sbjct: 327 RFSNGLMVTCSKDRSIAVWDMASA------TDITLRRVLVGHRAAVNVVDFDDKYIVSAS 380
Query: 183 HDDTILIW 206
D TI +W
Sbjct: 381 GDRTIKVW 388
Score = 30.4 bits (67), Expect = 6.4
Identities = 12/34 (35%), Positives = 24/34 (70%)
Frame = +3
Query: 108 LQTLTQHTGRVFRLQFDEFQIVSSSHDDTILIWD 209
+Q ++++ V+ LQ+D+ +I+S D++I IWD
Sbjct: 233 IQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWD 266
>sp|Q9Y297|FBW1A_HUMAN F-box/WD-repeat protein 1A (F-box and WD-repeats protein beta-TrCP)
(E3RSIkappaB) (pIkappaBalpha-E3 receptor subunit)
Length = 605
Score = 129 bits (325), Expect = 8e-30
Identities = 60/72 (83%), Positives = 69/72 (95%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
RFD+K IVSGAYDGKIKVWDLVAAL+P++PA +LCL+TL +H+GRVFRLQFDEFQIVSSS
Sbjct: 513 RFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSS 572
Query: 183 HDDTILIWDFLD 218
HDDTILIWDFL+
Sbjct: 573 HDDTILIWDFLN 584
Score = 54.7 bits (130), Expect = 3e-07
Identities = 31/75 (41%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSL-CLQTLTQHTGRVFRLQFDEFQIVSS 179
++D + IVSG D IK+WD N+L C + LT HTG V LQ+DE I++
Sbjct: 310 QYDDQKIVSGLRDNTIKIWD----------KNTLECKRILTGHTGSVLCLQYDERVIITG 359
Query: 180 SHDDTILIWDFLDTG 224
S D T+ +WD ++TG
Sbjct: 360 SSDSTVRVWD-VNTG 373
Score = 44.3 bits (103), Expect = 4e-04
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Frame = +3
Query: 6 FDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLC--LQTLTQHTGRVFRLQFDEFQIVSS 179
FD KYIVS + D IKVW+ S C ++TL H + LQ+ + +VS
Sbjct: 434 FDDKYIVSASGDRTIKVWN-----------TSTCEFVRTLNGHKRGIACLQYRDRLVVSG 482
Query: 180 SHDDTILIWD 209
S D+TI +WD
Sbjct: 483 SSDNTIRLWD 492
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/71 (29%), Positives = 37/71 (52%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
++ + +VSG+ D I++WD+ CL+ L H V ++FD +IVS +
Sbjct: 473 QYRDRLVVSGSSDNTIRLWDIECGA---------CLRVLEGHEELVRCIRFDNKRIVSGA 523
Query: 183 HDDTILIWDFL 215
+D I +WD +
Sbjct: 524 YDGKIKVWDLV 534
Score = 39.3 bits (90), Expect = 0.014
Identities = 23/69 (33%), Positives = 36/69 (52%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
RF++ +V+ + D I VWD+ SP + + L H V + FD+ IVS+S
Sbjct: 390 RFNNGMMVTCSKDRSIAVWDMA------SPTDITLRRVLVGHRAAVNVVDFDDKYIVSAS 443
Query: 183 HDDTILIWD 209
D TI +W+
Sbjct: 444 GDRTIKVWN 452
Score = 30.4 bits (67), Expect = 6.4
Identities = 13/24 (54%), Positives = 18/24 (75%)
Frame = +3
Query: 138 VFRLQFDEFQIVSSSHDDTILIWD 209
V+ LQ+D+ +IVS D+TI IWD
Sbjct: 306 VYCLQYDDQKIVSGLRDNTIKIWD 329
>sp|Q91854|TRCB_XENLA Beta-TrCP (Beta-transducin repeat-containing protein)
Length = 518
Score = 129 bits (325), Expect = 8e-30
Identities = 60/72 (83%), Positives = 69/72 (95%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
RFD+K IVSGAYDGKIKVWDLVAAL+P++PA +LCL+TL +H+GRVFRLQFDEFQIVSSS
Sbjct: 442 RFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSS 501
Query: 183 HDDTILIWDFLD 218
HDDTILIWDFL+
Sbjct: 502 HDDTILIWDFLN 513
Score = 52.8 bits (125), Expect = 1e-06
Identities = 30/75 (40%), Positives = 43/75 (57%), Gaps = 1/75 (1%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSL-CLQTLTQHTGRVFRLQFDEFQIVSS 179
++D + IVSG D IK+WD N+L C + L HTG V LQ+DE I++
Sbjct: 239 QYDDQKIVSGLRDNTIKIWD----------KNTLECKRVLMGHTGSVLCLQYDERVIITG 288
Query: 180 SHDDTILIWDFLDTG 224
S D T+ +WD ++TG
Sbjct: 289 SSDSTVRVWD-VNTG 302
Score = 44.3 bits (103), Expect = 4e-04
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Frame = +3
Query: 6 FDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLC--LQTLTQHTGRVFRLQFDEFQIVSS 179
FD KYIVS + D IKVW+ S C ++TL H + LQ+ + +VS
Sbjct: 363 FDDKYIVSASGDRTIKVWN-----------TSTCEFVRTLNGHKRGIACLQYRDRLVVSG 411
Query: 180 SHDDTILIWD 209
S D+TI +WD
Sbjct: 412 SSDNTIRLWD 421
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/71 (29%), Positives = 37/71 (52%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
++ + +VSG+ D I++WD+ CL+ L H V ++FD +IVS +
Sbjct: 402 QYRDRLVVSGSSDNTIRLWDIECGA---------CLRVLEGHEELVRCIRFDNKRIVSGA 452
Query: 183 HDDTILIWDFL 215
+D I +WD +
Sbjct: 453 YDGKIKVWDLV 463
Score = 37.0 bits (84), Expect = 0.069
Identities = 22/69 (31%), Positives = 36/69 (52%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
RF++ +V+ + D I VWD+ +A + + L H V + FD+ IVS+S
Sbjct: 319 RFNNGMMVTCSKDRSIAVWDMASA------TDITLRRVLVGHRAAVNVVDFDDKYIVSAS 372
Query: 183 HDDTILIWD 209
D TI +W+
Sbjct: 373 GDRTIKVWN 381
Score = 30.4 bits (67), Expect = 6.4
Identities = 13/24 (54%), Positives = 18/24 (75%)
Frame = +3
Query: 138 VFRLQFDEFQIVSSSHDDTILIWD 209
V+ LQ+D+ +IVS D+TI IWD
Sbjct: 235 VYCLQYDDQKIVSGLRDNTIKIWD 258
>sp|Q09990|LIN23_CAEEL F-box/WD-repeat protein lin-23 (Abnormal cell lineage protein 23)
Length = 665
Score = 121 bits (304), Expect = 2e-27
Identities = 57/72 (79%), Positives = 65/72 (90%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
RFD K IVSGAYDGKIKVWDL AAL+P++ ++ +CL +L QHTGRVFRLQFD+FQIVSSS
Sbjct: 432 RFDEKRIVSGAYDGKIKVWDLQAALDPRALSSEICLCSLVQHTGRVFRLQFDDFQIVSSS 491
Query: 183 HDDTILIWDFLD 218
HDDTILIWDFLD
Sbjct: 492 HDDTILIWDFLD 503
Score = 50.1 bits (118), Expect = 8e-06
Identities = 28/74 (37%), Positives = 40/74 (54%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
++D IVSG D IK+WD + C + L+ HTG V LQ+D I+S S
Sbjct: 229 QYDDDKIVSGLRDNTIKIWDR---------KDYSCSRILSGHTGSVLCLQYDNRVIISGS 279
Query: 183 HDDTILIWDFLDTG 224
D T+ +WD ++TG
Sbjct: 280 SDATVRVWD-VETG 292
Score = 45.1 bits (105), Expect = 3e-04
Identities = 22/69 (31%), Positives = 39/69 (56%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
++ + +VSG+ D I++WD+ + +CL+ L H V ++FDE +IVS +
Sbjct: 392 QYRGRLVVSGSSDNTIRLWDI---------HSGVCLRVLEGHEELVRCIRFDEKRIVSGA 442
Query: 183 HDDTILIWD 209
+D I +WD
Sbjct: 443 YDGKIKVWD 451
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/71 (29%), Positives = 38/71 (53%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
++D++ I+SG+ D ++VWD+ C++TL H V L+F +V+ S
Sbjct: 269 QYDNRVIISGSSDATVRVWDV---------ETGECIKTLIHHCEAVLHLRFANGIMVTCS 319
Query: 183 HDDTILIWDFL 215
D +I +WD +
Sbjct: 320 KDRSIAVWDMV 330
Score = 39.7 bits (91), Expect = 0.011
Identities = 24/68 (35%), Positives = 34/68 (50%)
Frame = +3
Query: 6 FDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSH 185
FD +YIVS + D IKVW + ++TL H + LQ+ +VS S
Sbjct: 353 FDDRYIVSASGDRTIKVWSMDTLE---------FVRTLAGHRRGIACLQYRGRLVVSGSS 403
Query: 186 DDTILIWD 209
D+TI +WD
Sbjct: 404 DNTIRLWD 411
Score = 39.3 bits (90), Expect = 0.014
Identities = 26/73 (35%), Positives = 38/73 (52%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
RF + +V+ + D I VWD+V SP + + L H V + FD+ IVS+S
Sbjct: 309 RFANGIMVTCSKDRSIAVWDMV------SPRDITIRRVLVGHRAAVNVVDFDDRYIVSAS 362
Query: 183 HDDTILIWDFLDT 221
D TI +W +DT
Sbjct: 363 GDRTIKVWS-MDT 374
Score = 31.2 bits (69), Expect = 3.8
Identities = 14/33 (42%), Positives = 23/33 (69%)
Frame = +3
Query: 120 TQHTGRVFRLQFDEFQIVSSSHDDTILIWDFLD 218
++++ V+ LQ+D+ +IVS D+TI IWD D
Sbjct: 219 SENSKGVYCLQYDDDKIVSGLRDNTIKIWDRKD 251
>sp|Q969H0|FBXW7_HUMAN F-box/WD-repeat protein 7 (F-box and WD-40 domain protein 7) (F-box
protein FBX30) (hCdc4) (Archipelago homolog) (hAgo)
(SEL-10)
Length = 707
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/74 (44%), Positives = 44/74 (59%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
++D + +VSGAYD +KVWD P CL TL HT RV+ LQFD +VS S
Sbjct: 508 QYDGRRVVSGAYDFMVKVWD---------PETETCLHTLQGHTNRVYSLQFDGIHVVSGS 558
Query: 183 HDDTILIWDFLDTG 224
D +I +WD ++TG
Sbjct: 559 LDTSIRVWD-VETG 571
Score = 44.3 bits (103), Expect = 4e-04
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Frame = +3
Query: 21 IVSGAYDGKIKVWDLVAALNPQSPANSLCLQTL---TQHTGRVFRLQFDEFQIVSSSHDD 191
+VSG D +K+WD+ CLQTL +H V LQF++ +++SS D
Sbjct: 594 LVSGNADSTVKIWDI---------KTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDG 644
Query: 192 TILIWD-----FLDTGVNQDSGMNMVRSPVVSLDNDDEPIKPVGEQGSMNNASTSQNLVF 356
T+ +WD F+ V +SG + + N K V GS N ++ LV
Sbjct: 645 TVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASN----TKLVCAVGSRNGTEETKLLVL 700
Query: 357 EYDLN 371
++D++
Sbjct: 701 DFDVD 705
Score = 43.9 bits (102), Expect = 6e-04
Identities = 25/69 (36%), Positives = 35/69 (50%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
+F IVSG+ D +KVW V CL+TL HTG V+ Q + I+S S
Sbjct: 388 QFCGNRIVSGSDDNTLKVWSAVTGK---------CLRTLVGHTGGVWSSQMRDNIIISGS 438
Query: 183 HDDTILIWD 209
D T+ +W+
Sbjct: 439 TDRTLKVWN 447
Score = 41.2 bits (95), Expect = 0.004
Identities = 20/65 (30%), Positives = 33/65 (50%)
Frame = +3
Query: 15 KYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHDDT 194
K +VSG+ D ++VWD+ CL L H V +Q+D ++VS ++D
Sbjct: 472 KRVVSGSRDATLRVWDI---------ETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFM 522
Query: 195 ILIWD 209
+ +WD
Sbjct: 523 VKVWD 527
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/68 (33%), Positives = 35/68 (51%)
Frame = +3
Query: 21 IVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHDDTIL 200
I+SG+ D +KVW+ C+ TL HT V + E ++VS S D T+
Sbjct: 434 IISGSTDRTLKVWNA---------ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLR 484
Query: 201 IWDFLDTG 224
+WD ++TG
Sbjct: 485 VWD-IETG 491
>sp|Q8VBV4|FBXW7_MOUSE F-box/WD-repeat protein 7 (F-box and WD-40 domain protein 7) (F-box
protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat
protein 6) (SEL-10)
Length = 629
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/74 (44%), Positives = 44/74 (59%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
++D + +VSGAYD +KVWD P CL TL HT RV+ LQFD +VS S
Sbjct: 430 QYDGRRVVSGAYDFMVKVWD---------PETETCLHTLQGHTNRVYSLQFDGIHVVSGS 480
Query: 183 HDDTILIWDFLDTG 224
D +I +WD ++TG
Sbjct: 481 LDTSIRVWD-VETG 493
Score = 44.7 bits (104), Expect = 3e-04
Identities = 36/125 (28%), Positives = 59/125 (47%), Gaps = 8/125 (6%)
Frame = +3
Query: 21 IVSGAYDGKIKVWDLVAALNPQSPANSLCLQTL---TQHTGRVFRLQFDEFQIVSSSHDD 191
+VSG D +K+WD+ CLQTL ++H V LQF++ +++SS D
Sbjct: 516 LVSGNADSTVKIWDI---------KTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDG 566
Query: 192 TILIWD-----FLDTGVNQDSGMNMVRSPVVSLDNDDEPIKPVGEQGSMNNASTSQNLVF 356
T+ +WD F+ V +SG + + N K V GS N ++ LV
Sbjct: 567 TVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASN----TKLVCAVGSRNGTEETKLLVL 622
Query: 357 EYDLN 371
++D++
Sbjct: 623 DFDVD 627
Score = 43.9 bits (102), Expect = 6e-04
Identities = 25/69 (36%), Positives = 35/69 (50%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
+F IVSG+ D +KVW V CL+TL HTG V+ Q + I+S S
Sbjct: 310 QFCGNRIVSGSDDNTLKVWSAVTGK---------CLRTLVGHTGGVWSSQMRDNIIISGS 360
Query: 183 HDDTILIWD 209
D T+ +W+
Sbjct: 361 TDRTLKVWN 369
Score = 41.2 bits (95), Expect = 0.004
Identities = 20/65 (30%), Positives = 33/65 (50%)
Frame = +3
Query: 15 KYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHDDT 194
K +VSG+ D ++VWD+ CL L H V +Q+D ++VS ++D
Sbjct: 394 KRVVSGSRDATLRVWDI---------ETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFM 444
Query: 195 ILIWD 209
+ +WD
Sbjct: 445 VKVWD 449
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/68 (33%), Positives = 35/68 (51%)
Frame = +3
Query: 21 IVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHDDTIL 200
I+SG+ D +KVW+ C+ TL HT V + E ++VS S D T+
Sbjct: 356 IISGSTDRTLKVWNA---------ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLR 406
Query: 201 IWDFLDTG 224
+WD ++TG
Sbjct: 407 VWD-IETG 413
>sp|Q9VZF4|FBXW7_DROME F-box/WD-repeat protein 7 (F-box and WD-40 domain protein 7)
(Archipelago protein)
Length = 1326
Score = 64.3 bits (155), Expect = 4e-10
Identities = 41/108 (37%), Positives = 57/108 (52%), Gaps = 9/108 (8%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
++D K IVSGAYD +K+W P CL TL HT RV+ LQFD +VS S
Sbjct: 1122 QYDGKLIVSGAYDYMVKIWH---------PERQECLHTLQGHTNRVYSLQFDGLHVVSGS 1172
Query: 183 HDDTILIWDFLDTG---------VNQDSGMNMVRSPVVSLDNDDEPIK 299
D +I +WD ++TG + SGM + ++ +VS N D +K
Sbjct: 1173 LDTSIRVWD-VETGNCKHTLMGHQSLTSGMELRQNILVS-GNADSTVK 1218
Score = 49.7 bits (117), Expect = 1e-05
Identities = 29/74 (39%), Positives = 39/74 (52%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
+F IVSG+ D +KVW V N CL+TL HTG V+ Q I+S S
Sbjct: 1002 QFSGNRIVSGSDDNTLKVWSAV---------NGKCLRTLVGHTGGVWSSQMSGNIIISGS 1052
Query: 183 HDDTILIWDFLDTG 224
D T+ +WD +D+G
Sbjct: 1053 TDRTLKVWD-MDSG 1065
Score = 45.1 bits (105), Expect = 3e-04
Identities = 40/129 (31%), Positives = 61/129 (47%), Gaps = 13/129 (10%)
Frame = +3
Query: 21 IVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLT---QHTGRVFRLQFDEFQIVSSSHDD 191
+VSG D +KVWD+ CLQTL+ +H V LQF+ +V+SS D
Sbjct: 1208 LVSGNADSTVKVWDITTGQ---------CLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDG 1258
Query: 192 TILIW-----DFLDTGVNQDSGMN-----MVRSPVVSLDNDDEPIKPVGEQGSMNNASTS 341
T+ +W DF+ V DSG + +R+ ND + I V GS N +
Sbjct: 1259 TVKLWDVKTGDFIRNLVALDSGGSGGVVWRIRA------NDTKLICAV---GSRNGTEET 1309
Query: 342 QNLVFEYDL 368
+ +V ++D+
Sbjct: 1310 KLMVLDFDV 1318
Score = 41.2 bits (95), Expect = 0.004
Identities = 21/63 (33%), Positives = 32/63 (50%)
Frame = +3
Query: 21 IVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHDDTIL 200
I+SG+ D +KVWD+ + C+ TL HT V + ++VS S D T+
Sbjct: 1048 IISGSTDRTLKVWDM---------DSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDATLR 1098
Query: 201 IWD 209
+WD
Sbjct: 1099 VWD 1101
Score = 37.4 bits (85), Expect = 0.053
Identities = 20/62 (32%), Positives = 30/62 (48%)
Frame = +3
Query: 21 IVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHDDTIL 200
+VSG+ D ++VWD+ CL L H V +Q+D IVS ++D +
Sbjct: 1088 VVSGSRDATLRVWDI---------EQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVK 1138
Query: 201 IW 206
IW
Sbjct: 1139 IW 1140
>sp|Q09855|POF11_SCHPO F-box/WD-repeat protein pof11
Length = 506
Score = 50.4 bits (119), Expect = 6e-06
Identities = 25/72 (34%), Positives = 43/72 (59%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
RF+ + IVSG YDG +++W+ + C+ ++++ RVF LQFD +I++ +
Sbjct: 436 RFNDEKIVSGGYDGTVRIWNF-------NTGEQHCVLHNSRNS-RVFGLQFDHRRIIACT 487
Query: 183 HDDTILIWDFLD 218
H IL+W+F D
Sbjct: 488 HSSEILVWNFDD 499
Score = 39.3 bits (90), Expect = 0.014
Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 2/72 (2%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQ--IVS 176
++D + +VSG+ D + VWD+ + L L H+G V L F + +VS
Sbjct: 228 QYDDEIMVSGSKDRTVSVWDV---------NSRFILYKLYGHSGSVLCLDFCRRRNLLVS 278
Query: 177 SSHDDTILIWDF 212
S D TI+IWD+
Sbjct: 279 GSSDSTIIIWDW 290
Score = 38.1 bits (87), Expect = 0.031
Identities = 27/98 (27%), Positives = 49/98 (50%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
+++ K+IVSG+ D I++++ ++ L+ L H + ++F++ +IVS
Sbjct: 396 QYNGKFIVSGSSDLTIRIFEA---------SSGKLLRMLQGHEDLIRTVRFNDEKIVSGG 446
Query: 183 HDDTILIWDFLDTGVNQDSGMNMVRSPVVSLDNDDEPI 296
+D T+ IW+F +TG N S V L D I
Sbjct: 447 YDGTVRIWNF-NTGEQHCVLHNSRNSRVFGLQFDHRRI 483
Score = 35.0 bits (79), Expect = 0.26
Identities = 25/87 (28%), Positives = 41/87 (47%)
Frame = +3
Query: 21 IVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHDDTIL 200
+VSG+ D I +WD N L+ HT V + E I+SSS D T
Sbjct: 276 LVSGSSDSTIIIWDW---------QNRRPLKVYFGHTDNVLGVVVSENYIISSSRDHTAR 326
Query: 201 IWDFLDTGVNQDSGMNMVRSPVVSLDN 281
+W LD ++ M+++R + S+++
Sbjct: 327 VWR-LDATSPAEACMHVLRGHLASVNS 352
>sp|Q01277|SCON2_NEUCR Sulfur controller 2 (SCON2)
Length = 650
Score = 49.7 bits (117), Expect = 1e-05
Identities = 22/70 (31%), Positives = 39/70 (55%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
+ D + +G+YD IK+W++ C++TL HT + LQFD+ +++S S
Sbjct: 301 QLDDNILATGSYDTTIKIWNI---------ETEECIRTLVGHTAGIRALQFDDSKLISGS 351
Query: 183 HDDTILIWDF 212
D TI +W++
Sbjct: 352 LDHTIKVWNW 361
Score = 44.3 bits (103), Expect = 4e-04
Identities = 24/70 (34%), Positives = 33/70 (47%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSS 182
+FD ++SG+ D IKVW+ CL T HT V + FD + S S
Sbjct: 341 QFDDSKLISGSLDHTIKVWNW---------HTGECLSTFAAHTDSVISVHFDGHLLASGS 391
Query: 183 HDDTILIWDF 212
D T+ I+DF
Sbjct: 392 SDKTVKIFDF 401
Score = 37.0 bits (84), Expect = 0.069
Identities = 17/65 (26%), Positives = 32/65 (49%)
Frame = +3
Query: 15 KYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHDDT 194
+Y ++G D +++WD A CL+TL H V+ L D +++S ++D
Sbjct: 549 RYFMTGGLDSTMRLWD---------SATGRCLRTLFGHLEGVWSLAGDTIRVISGANDGM 599
Query: 195 ILIWD 209
+ W+
Sbjct: 600 VKTWE 604
Score = 36.2 bits (82), Expect = 0.12
Identities = 21/68 (30%), Positives = 31/68 (45%)
Frame = +3
Query: 9 DSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHD 188
D+ ++SGA DG +K W+ P + C T T H G V + + + S S D
Sbjct: 587 DTIRVISGANDGMVKTWE---------PRSGKCDATYTGHCGPVTCVGLSDSLMASGSED 637
Query: 189 DTILIWDF 212
TI + F
Sbjct: 638 GTIRLHSF 645
>sp|Q93794|SEL10_CAEEL F-box/WD-repeat protein sel-10 (Suppressor/enhancer of lin-12)
(Sel-10 protein)
Length = 587
Score = 48.1 bits (113), Expect = 3e-05
Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Frame = +3
Query: 3 RFDSKYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQ--IVS 176
+FD +VSG YD +K+W + C++TLT H RV+ L F+ + + S
Sbjct: 385 QFDGTTVVSGGYDFTVKIW---------NAHTGRCIRTLTGHNNRVYSLLFESERSIVCS 435
Query: 177 SSHDDTILIWDF 212
S D +I +WDF
Sbjct: 436 GSLDTSIRVWDF 447
Score = 37.7 bits (86), Expect = 0.040
Identities = 22/65 (33%), Positives = 31/65 (47%)
Frame = +3
Query: 15 KYIVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHDDT 194
+YIVSG+ D +KVW S + L TL HT V + +V+ S D T
Sbjct: 309 RYIVSGSTDRTVKVW---------STVDGSLLHTLQGHTSTVRCMAMAGSILVTGSRDTT 359
Query: 195 ILIWD 209
+ +WD
Sbjct: 360 LRVWD 364
Score = 35.8 bits (81), Expect = 0.15
Identities = 20/63 (31%), Positives = 33/63 (52%)
Frame = +3
Query: 21 IVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHDDTIL 200
+V+G+ D ++VWD+ + + L TL H V +QFD +VS +D T+
Sbjct: 351 LVTGSRDTTLRVWDVESGRH---------LATLHGHHAAVRCVQFDGTTVVSGGYDFTVK 401
Query: 201 IWD 209
IW+
Sbjct: 402 IWN 404
Score = 34.3 bits (77), Expect = 0.45
Identities = 26/86 (30%), Positives = 38/86 (44%), Gaps = 1/86 (1%)
Frame = +3
Query: 21 IVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEFQIVSSSHDDTIL 200
+ SG+ D I+VWD P C+ L HT +Q +VS + D +
Sbjct: 433 VCSGSLDTSIRVWDFTR------PEGQECVALLQGHTSLTSGMQLRGNILVSCNADSHVR 486
Query: 201 IWDFLD-TGVNQDSGMNMVRSPVVSL 275
+WD + T V+ SG RS + SL
Sbjct: 487 VWDIHEGTCVHMLSGH---RSAITSL 509
Score = 32.3 bits (72), Expect = 1.7
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 2/68 (2%)
Frame = +3
Query: 21 IVSGAYDGKIKVWDLVAALNPQSPANSLCLQTLTQHTGRVFRLQFDEF--QIVSSSHDDT 194
+V+G+ D +KVW + + TL HTG V+ Q + IVS S D T
Sbjct: 269 LVTGSDDNTLKVWCI---------DKGEVMYTLVGHTGGVWTSQISQCGRYIVSGSTDRT 319
Query: 195 ILIWDFLD 218
+ +W +D
Sbjct: 320 VKVWSTVD 327
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,432,599
Number of Sequences: 369166
Number of extensions: 1339832
Number of successful extensions: 4248
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3414
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4069
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)