Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_E08
(839 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (En... 107 3e-23
sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor... 99 1e-20
sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor... 99 2e-20
sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metal... 99 2e-20
sp|P23097|MMP13_RAT Collagenase 3 precursor (Matrix metallo... 98 2e-20
sp|P91953|HE_HEMPU 50 kDa hatching enzyme precursor (HE) (H... 98 3e-20
sp|P45452|MMP13_HUMAN Collagenase 3 precursor (Matrix metal... 97 6e-20
sp|P51512|MMP16_HUMAN Matrix metalloproteinase-16 precursor... 97 6e-20
sp|Q9WTR0|MMP16_MOUSE Matrix metalloproteinase-16 precursor... 97 7e-20
sp|O35548|MMP16_RAT Matrix metalloproteinase-16 precursor (... 97 7e-20
>sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (Envelysin)
(Sea-urchin-hatching proteinase) [Contains: Hatching
enzyme 18 kDa form]
Length = 587
Score = 107 bits (268), Expect = 3e-23
Identities = 51/86 (59%), Positives = 64/86 (74%)
Frame = +2
Query: 110 GGVLAHAYFPRNGNLHCDNAETWTEGKDSGINLRIVAAHEMGHAIGLHHSQDPSALMAPW 289
GGVLAHA+ PRNG+ H D++ETWTEG SG NL VAAHE GH++GL+HS SALM P+
Sbjct: 245 GGVLAHAFLPRNGDAHFDDSETWTEGTRSGTNLFQVAAHEFGHSLGLYHSTVRSALMYPY 304
Query: 290 YGGYISEAEYRLPNDDTLGAQSIYGA 367
Y GY+ +RL NDD G +S+YG+
Sbjct: 305 YQGYV--PNFRLDNDDIAGIRSLYGS 328
>sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor (MMP-19) (Matrix
metalloproteinase RASI)
Length = 527
Score = 99.4 bits (246), Expect = 1e-20
Identities = 68/188 (36%), Positives = 96/188 (51%), Gaps = 10/188 (5%)
Frame = +2
Query: 107 PGGVLAHAYFPRNGNLHCDNAETWTEGKDSGINLRIVAAHEMGHAIGLHHSQDPSALMAP 286
PG VLAHA P G++H D E WTEG G+NLRI+AAHE+GHA+GL HS+ ALMAP
Sbjct: 174 PGKVLAHADIPELGSIHFDKDELWTEGTYQGVNLRIIAAHEVGHALGLGHSRYTQALMAP 233
Query: 287 WYGGYISEAEYRLPNDDTLGAQSIYGARGKRALPSKKR----ELGKIQSR---LCNVKSF 445
Y GY + ++L DD G Q++YG R ++ + + ++ + N S
Sbjct: 234 VYAGY--QPFFKLHPDDVAGIQALYGKRSPETRDEEEETEMLTVSPVTAKPGPMPNPCSG 291
Query: 446 E-DVFTFSD-GKVYVLADGGNLFRMNDDKVDETFEPVKINEALM-NVDSTFYDNVKKRLI 616
E D GK Y G ++ + D F+ + E L N+D+ Y +R
Sbjct: 292 EVDAMVLGPRGKTYAF-KGDYVWTVTDSGPGPLFQISALWEGLPGNLDAAVYSPRTRRTH 350
Query: 617 AFKGEKAF 640
FKG K +
Sbjct: 351 FFKGNKVW 358
>sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 98.6 bits (244), Expect = 2e-20
Identities = 77/223 (34%), Positives = 103/223 (46%), Gaps = 11/223 (4%)
Frame = +2
Query: 29 SGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPRNG---NLHCDNAETWTEGKDSG 199
SG+ +M + +N D P D P G LAHA+ P G + H DNAE WT G + G
Sbjct: 162 SGEADIMISFENG--DHGDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTN-G 217
Query: 200 INLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGAR--- 370
NL VAAHE GHA+GL HS DPSALM P Y Y + + LP DD G Q++YG R
Sbjct: 218 FNLFTVAAHEFGHALGLAHSTDPSALMYPTY-KYKNPYGFHLPKDDVKGIQALYGPRKVF 276
Query: 371 -GKRALPSKKRELGKIQSRLCNVKSFEDVFTFSDGKVYVLADGGNLFRMNDDKVDETFEP 547
GK LP I LC+ S D T ++ + D +F + P
Sbjct: 277 LGKPTLPHAPHHKPSIPD-LCDSSSSFDAVTMLGKELLLFKD--RIFWRRQVHLRTGIRP 333
Query: 548 VKIN----EALMNVDSTFYDNVKKRLIAFKGEKAFSVTGSDIE 664
I + + NVD+ + + FKG + G ++
Sbjct: 334 STITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQ 376
>sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/219 (33%), Positives = 106/219 (48%), Gaps = 5/219 (2%)
Frame = +2
Query: 20 ISFSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPR---NGNLHCDNAETWTEGK 190
ISF K+H D P D P G+LAHA+ P G+ H D+ ETWT
Sbjct: 165 ISFGTKEH------------GDFYPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSS 211
Query: 191 DSGINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGAR 370
G NL +VAAHE GH++GL HS+DP ALM P Y Y ++ + LP+DD G QS+YG
Sbjct: 212 -KGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPG 269
Query: 371 GKRALPSKKRELGKIQSRLCNVKSFEDVFTFSDGKVYVLADGGNLFRMNDDKVD-ETFEP 547
+ P + K C+ D T G+ + D +R++ +VD E F
Sbjct: 270 DEDPNPKHPKTPDK-----CDPSLSLDAITSLRGETMIFKD-RFFWRLHPQQVDAELFLT 323
Query: 548 VKINEALMN-VDSTFYDNVKKRLIAFKGEKAFSVTGSDI 661
L N +D+ + + + F+G+K ++ G DI
Sbjct: 324 KSFWPELPNRIDAAYEHPARDLIFIFRGKKFWAPNGYDI 362
>sp|P23097|MMP13_RAT Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
(UMRCASE)
Length = 466
Score = 98.2 bits (243), Expect = 2e-20
Identities = 75/219 (34%), Positives = 107/219 (48%), Gaps = 5/219 (2%)
Frame = +2
Query: 20 ISFSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPR---NGNLHCDNAETWTEGK 190
ISF K+H D P D P G+LAHA+ P G+ H D+ ETWT
Sbjct: 160 ISFGTKEH------------GDFYPFDG-PSGLLAHAFPPGPNLGGDAHFDDDETWTSSS 206
Query: 191 DSGINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGAR 370
G NL IVAAHE+GH++GL HS+DP ALM P Y Y ++ + LP+DD G QS+YG
Sbjct: 207 -KGYNLFIVAAHELGHSLGLDHSKDPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPG 264
Query: 371 GKRALPSKKRELGKIQSRLCNVKSFEDVFTFSDGKVYVLADGGNLFRMNDDKVD-ETFEP 547
+ P + K C+ D T G+ + D +R++ +V+ E F
Sbjct: 265 DEDPNPKHPKTPEK-----CDPALSLDAITSLRGETMIFKD-RFFWRLHPQQVEPELFLT 318
Query: 548 VKINEALMN-VDSTFYDNVKKRLIAFKGEKAFSVTGSDI 661
L N VD+ + + + F+G K +++ G DI
Sbjct: 319 KSFWPELPNHVDAAYEHPSRDLMFIFRGRKFWALNGYDI 357
>sp|P91953|HE_HEMPU 50 kDa hatching enzyme precursor (HE) (HEZ) (Envelysin)
(Sea-urchin-hatching proteinase) [Contains: 38 kDa
hatching enzyme; 32 kDa hatching enzyme non-specific; 15
kDa peptide]
Length = 591
Score = 97.8 bits (242), Expect = 3e-20
Identities = 47/85 (55%), Positives = 58/85 (68%)
Frame = +2
Query: 110 GGVLAHAYFPRNGNLHCDNAETWTEGKDSGINLRIVAAHEMGHAIGLHHSQDPSALMAPW 289
GGVLAHA+ PRNG+ H D++E WT G +SG NL VAAHE GH++GL+HS SALM P+
Sbjct: 248 GGVLAHAFLPRNGDAHFDDSERWTIGTNSGTNLFQVAAHEFGHSLGLYHSDVQSALMYPY 307
Query: 290 YGGYISEAEYRLPNDDTLGAQSIYG 364
Y GY + L DD G S+YG
Sbjct: 308 YRGY--NPNFNLDRDDIAGITSLYG 330
>sp|P45452|MMP13_HUMAN Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 97.1 bits (240), Expect = 6e-20
Identities = 70/195 (35%), Positives = 98/195 (50%), Gaps = 5/195 (2%)
Frame = +2
Query: 92 PLDNVPGGVLAHAYFPR---NGNLHCDNAETWTEGKDSGINLRIVAAHEMGHAIGLHHSQ 262
P D P G+LAHA+ P G+ H D+ ETWT G NL +VAAHE GH++GL HS+
Sbjct: 177 PFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSS-KGYNLFLVAAHEFGHSLGLDHSK 234
Query: 263 DPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGARGKRALPSKKRELGKIQSRLCNVKS 442
DP ALM P Y Y ++ + LP+DD G QS+YG + P + K C+
Sbjct: 235 DPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDK-----CDPSL 288
Query: 443 FEDVFTFSDGKVYVLADGGNLFRMNDDKVD-ETFEPVKINEALMNVDSTFYDNVKKRLI- 616
D T G+ + D +R++ +VD E F L N Y++ LI
Sbjct: 289 SLDAITSLRGETMIFKD-RFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIF 347
Query: 617 AFKGEKAFSVTGSDI 661
F+G K +++ G DI
Sbjct: 348 IFRGRKFWALNGYDI 362
>sp|P51512|MMP16_HUMAN Matrix metalloproteinase-16 precursor (MMP-16) (Membrane-type
matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP) (MMP-X2)
Length = 607
Score = 97.1 bits (240), Expect = 6e-20
Identities = 53/109 (48%), Positives = 68/109 (62%), Gaps = 5/109 (4%)
Frame = +2
Query: 83 DPSPLDNVPGGVLAHAYFPR---NGNLHCDNAETWTEGKDS--GINLRIVAAHEMGHAIG 247
D SP D GG LAHAYFP G+ H D+ E WT G + G +L +VA HE+GHA+G
Sbjct: 195 DSSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALG 253
Query: 248 LHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGARGKRALPSK 394
L HS DP+A+MAP+Y Y+ ++LPNDD G Q IYG K P++
Sbjct: 254 LEHSNDPTAIMAPFY-QYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTR 301
>sp|Q9WTR0|MMP16_MOUSE Matrix metalloproteinase-16 precursor (MMP-16) (Membrane-type
matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 96.7 bits (239), Expect = 7e-20
Identities = 53/109 (48%), Positives = 68/109 (62%), Gaps = 5/109 (4%)
Frame = +2
Query: 83 DPSPLDNVPGGVLAHAYFPR---NGNLHCDNAETWTEGKDS--GINLRIVAAHEMGHAIG 247
D SP D GG LAHAYFP G+ H D+ E WT G + G +L +VA HE+GHA+G
Sbjct: 195 DRSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALG 253
Query: 248 LHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGARGKRALPSK 394
L HS DP+A+MAP+Y Y+ ++LPNDD G Q IYG K P++
Sbjct: 254 LEHSNDPTAIMAPFY-QYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTR 301
>sp|O35548|MMP16_RAT Matrix metalloproteinase-16 precursor (MMP-16) (Membrane-type
matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 96.7 bits (239), Expect = 7e-20
Identities = 53/109 (48%), Positives = 68/109 (62%), Gaps = 5/109 (4%)
Frame = +2
Query: 83 DPSPLDNVPGGVLAHAYFPR---NGNLHCDNAETWTEGKDS--GINLRIVAAHEMGHAIG 247
D SP D GG LAHAYFP G+ H D+ E WT G + G +L +VA HE+GHA+G
Sbjct: 195 DRSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALG 253
Query: 248 LHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGARGKRALPSK 394
L HS DP+A+MAP+Y Y+ ++LPNDD G Q IYG K P++
Sbjct: 254 LEHSNDPTAIMAPFY-QYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTR 301
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,214,614
Number of Sequences: 369166
Number of extensions: 2218409
Number of successful extensions: 6422
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6022
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6278
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8197207050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)