Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_D22
(604 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ULJ7|YB23_HUMAN Hypothetical protein KIAA1223 90 4e-18
sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4... 87 2e-17
sp|Q8Q0U0|Y045_METMA Hypothetical ANK-repeat protein MM0045 78 2e-14
sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyr... 78 2e-14
sp|Q59H18|TNI3K_HUMAN Serine/threonine-protein kinase TNNI3... 76 7e-14
sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G) 75 1e-13
sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin) 75 2e-13
sp|Q5RF15|TNI3K_PONPY Serine/threonine-protein kinase TNNI3... 75 2e-13
sp|Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase, H... 74 2e-13
sp|Q5GIG6|TNI3K_MOUSE Serine/threonine-protein kinase TNNI3... 74 4e-13
>sp|Q9ULJ7|YB23_HUMAN Hypothetical protein KIAA1223
Length = 768
Score = 90.1 bits (222), Expect = 4e-18
Identities = 51/124 (41%), Positives = 78/124 (62%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGA 196
G T L + QGH+E+ ++LI ADVNAA + + + L AA +GH + V+LL+++GA
Sbjct: 318 GRTALHVSCWQGHMEMVQVLIAYHADVNAAD--NEKRSALQSAAWQGHVKVVQLLIEHGA 375
Query: 197 IVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKE 376
+VD +G T L +A G+IDVV++L+E+ AD N +D T + A K GH +++K
Sbjct: 376 VVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKL 435
Query: 377 LVKY 388
L KY
Sbjct: 436 LEKY 439
Score = 84.7 bits (208), Expect = 2e-16
Identities = 52/157 (33%), Positives = 91/157 (57%), Gaps = 4/157 (2%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
R G L AA +GH ++ +L + ADVN R T+ I+A + T + L
Sbjct: 248 RGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDA-DGRPTLYILALENQLT-MAEYFL 305
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIK 364
+NGA V+A + +G T L ++C G++++V++LI Y ADVN++DN + + L +A +GH+K
Sbjct: 306 ENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVK 365
Query: 365 VVKELVKYVTQFPSEHDCNKHLKSI----KDGDKDIV 463
VV+ L+++ +H CN+ ++ ++G D+V
Sbjct: 366 VVQLLIEHGAVV--DHTCNQGATALCIAAQEGHIDVV 400
Score = 82.0 bits (201), Expect = 1e-15
Identities = 51/125 (40%), Positives = 67/125 (53%), Gaps = 3/125 (2%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRE---TVLIIAADKGHTEFVKLLLK 187
G T L+ AA GH E+ L++ A+VN V L + A KGH V LL+
Sbjct: 16 GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLID 75
Query: 188 NGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKV 367
GA VD +K G TPL +A G++DVV LL+E ADV+ +DN T L+ A GH V
Sbjct: 76 RGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASV 135
Query: 368 VKELV 382
V L+
Sbjct: 136 VNTLL 140
Score = 73.9 bits (180), Expect = 3e-13
Identities = 46/128 (35%), Positives = 71/128 (55%)
Frame = +2
Query: 2 HRAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLL 181
H K G+TPL+ AA +GHV+V +L+ ADV+ ++ T L+ AA GH V L
Sbjct: 82 HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD--HTDNNGRTPLLAAASMGHASVVNTL 139
Query: 182 LKNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHI 361
L GA VD+ + +G T L +A G ++VV+ L++ D N D+ T L A +GH
Sbjct: 140 LFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHR 199
Query: 362 KVVKELVK 385
+ + L++
Sbjct: 200 LICEALIE 207
Score = 70.9 bits (172), Expect = 2e-12
Identities = 45/126 (35%), Positives = 69/126 (54%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
R + L AS+GH V +LI+ A+V+ T L++AA +GH + V LLL
Sbjct: 50 RTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGM--TPLLVAAYEGHVDVVDLLL 107
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIK 364
+ GA VD + G TPL A + G+ VV L+ + A V+S D+ T L A +G+++
Sbjct: 108 EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVE 167
Query: 365 VVKELV 382
VV+ L+
Sbjct: 168 VVRTLL 173
Score = 66.6 bits (161), Expect = 5e-11
Identities = 51/156 (32%), Positives = 79/156 (50%), Gaps = 2/156 (1%)
Frame = +2
Query: 2 HRAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLL 181
H +G TPL+ AAS GH V L+ A V++ + S TVL IA+ +G+ E V+ L
Sbjct: 115 HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS--IDSEGRTVLSIASAQGNVEVVRTL 172
Query: 182 LKNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHI 361
L G + R+ G TPL +A G+ + + LIE A N DN + A ++GH
Sbjct: 173 LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHY 232
Query: 362 KVVKELVKYVTQFPSE-HDCNKHLK-SIKDGDKDIV 463
V+ L++ + +D L+ + +G +DIV
Sbjct: 233 DCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 268
Score = 62.0 bits (149), Expect = 1e-09
Identities = 37/104 (35%), Positives = 56/104 (53%)
Frame = +2
Query: 2 HRAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLL 181
HR +G TPL AA +GH + LI A N + + I+A+ +GH + V++L
Sbjct: 181 HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNE--IDNDGRIPFILASQEGHYDCVQIL 238
Query: 182 LKNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSD 313
L+N + +D R G L +A G+ D+V+LL + ADVN D
Sbjct: 239 LENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKD 282
Score = 55.8 bits (133), Expect = 8e-08
Identities = 41/109 (37%), Positives = 59/109 (54%), Gaps = 5/109 (4%)
Frame = +2
Query: 74 LINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAIVDARNKKGDTPLWLAC-- 247
L+ A+VN A + T LI AA GH E V+ LL +GA V+ + G T L +A
Sbjct: 2 LLQHGAEVNKAD--NEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC 59
Query: 248 ---NGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKELVK 385
+ G+ VV LLI+ A+V+ D MT L+ A +GH+ VV L++
Sbjct: 60 VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 108
Score = 53.1 bits (126), Expect = 5e-07
Identities = 33/89 (37%), Positives = 53/89 (59%)
Frame = +2
Query: 29 LMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAIVDA 208
L AA QGHV+V ++LI A V+ + T L IAA +GH + V++LL++GA +
Sbjct: 355 LQSAAWQGHVKVVQLLIEHGAVVDHTC--NQGATALCIAAQEGHIDVVQVLLEHGADPNH 412
Query: 209 RNKKGDTPLWLACNGGYIDVVKLLIEYKA 295
++ G T + +A G+ ++KLL +Y A
Sbjct: 413 ADQFGRTAMRVAAKNGHSQIIKLLEKYGA 441
Score = 31.2 bits (69), Expect = 2.1
Identities = 13/37 (35%), Positives = 24/37 (64%)
Frame = +2
Query: 278 LIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKELVKY 388
L+++ A+VN +DN T L+ A GH ++V+ L+ +
Sbjct: 2 LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH 38
>sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4 (Receptor-interacting
serine/threonine-protein kinase 4) (Ankyrin repeat domain
protein 3) (PKC-delta-interacting protein kinase)
Length = 832
Score = 87.4 bits (215), Expect = 2e-17
Identities = 54/122 (44%), Positives = 70/122 (57%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGA 196
G TPL AA +GH V RILI+ +DVN + + +T L +AA+ GHT +LLL GA
Sbjct: 652 GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLA--QTPLHVAAETGHTSTARLLLHRGA 709
Query: 197 IVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKE 376
+A G T L LA G++ VKLL+E KADV + T L A GH +VV+E
Sbjct: 710 GKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEE 769
Query: 377 LV 382
LV
Sbjct: 770 LV 771
Score = 52.4 bits (124), Expect = 9e-07
Identities = 38/125 (30%), Positives = 59/125 (47%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
+ G TPL A + V +L+ VNA + T L AA G +LLL+
Sbjct: 517 RRGSTPLHMAVERRVRGVVELLLARKISVNAKD--EDQWTALHFAAQNGDESSTRLLLEK 574
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
A V+ + +G TP+ +AC G ++V++L+ DV+ L A +GH+ +V
Sbjct: 575 NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIV 634
Query: 371 KELVK 385
K L K
Sbjct: 635 KLLAK 639
>sp|Q8Q0U0|Y045_METMA Hypothetical ANK-repeat protein MM0045
Length = 360
Score = 78.2 bits (191), Expect = 2e-14
Identities = 49/138 (35%), Positives = 76/138 (55%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
++G T L+ AA + H ++ +LI A AD+N +S +T L+ A GH V+LL+
Sbjct: 198 ENGETALICAADRAHRDIAELLIKAGADLNIQD--NSGKTALVAATKIGHKGIVELLVNA 255
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
GA ++ ++K G+T L A + GY D+V LLIE A +N D +T LM + + G +V
Sbjct: 256 GADLNLQDKNGNTALIYAADRGYRDIVNLLIEGGASLNIPDEAGLTALMFSAQTGRKDIV 315
Query: 371 KELVKYVTQFPSEHDCNK 424
+ L+K E NK
Sbjct: 316 ELLIKAGADINIEDKNNK 333
Score = 70.9 bits (172), Expect = 2e-12
Identities = 44/127 (34%), Positives = 67/127 (52%)
Frame = +2
Query: 14 SGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNG 193
SG T L+ A GH + +L+NA AD+N + T LI AAD+G+ + V LL++ G
Sbjct: 232 SGKTALVAATKIGHKGIVELLVNAGADLNLQD--KNGNTALIYAADRGYRDIVNLLIEGG 289
Query: 194 AIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVK 373
A ++ ++ G T L + G D+V+LLI+ AD+N D T A + G ++V
Sbjct: 290 ASLNIPDEAGLTALMFSAQTGRKDIVELLIKAGADINIEDKNNKTAADLAAEVGFEEIVD 349
Query: 374 ELVKYVT 394
L T
Sbjct: 350 LLTSVRT 356
Score = 61.2 bits (147), Expect = 2e-09
Identities = 39/118 (33%), Positives = 65/118 (55%), Gaps = 1/118 (0%)
Frame = +2
Query: 32 MEAASQGHVE-VGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAIVDA 208
+EA+ QG E V ++L + DVN +T LI AADKG+ + + LL+++G +D
Sbjct: 72 LEASKQGQTENVEKLLRSNKVDVNYQDAYG--KTALISAADKGYRDVIGLLIESGPNLDL 129
Query: 209 RNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKELV 382
+++ G+T L A D++ LL++ AD+N D T L A K G+ + +L+
Sbjct: 130 QDENGNTALISAAKIERGDIIDLLVKNGADLNFQDENGETALKFAVKVGYKNIADQLI 187
Score = 58.9 bits (141), Expect = 9e-09
Identities = 43/151 (28%), Positives = 75/151 (49%), Gaps = 2/151 (1%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGA 196
G T L+ AA +G+ +V +LI + +++ + T LI AA + + LL+KNGA
Sbjct: 101 GKTALISAADKGYRDVIGLLIESGPNLDLQD--ENGNTALISAAKIERGDIIDLLVKNGA 158
Query: 197 IVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKE 376
++ +++ G+T L A GY ++ LI+ D+N D T L+ A + H + +
Sbjct: 159 DLNFQDENGETALKFAVKVGYKNIADQLIDAGTDLNIQDENGETALICAADRAHRDIAEL 218
Query: 377 LVKYVTQFPSEHDCNKH--LKSIKDGDKDIV 463
L+K + + K + + K G K IV
Sbjct: 219 LIKAGADLNIQDNSGKTALVAATKIGHKGIV 249
Score = 57.4 bits (137), Expect = 3e-08
Identities = 38/124 (30%), Positives = 64/124 (51%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
++G T L+ AA ++ +L+ AD+N + ET L A G+ L+
Sbjct: 132 ENGNTALISAAKIERGDIIDLLVKNGADLNFQD--ENGETALKFAVKVGYKNIADQLIDA 189
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
G ++ +++ G+T L A + + D+ +LLI+ AD+N DN T L+ A K GH +V
Sbjct: 190 GTDLNIQDENGETALICAADRAHRDIAELLIKAGADLNIQDNSGKTALVAATKIGHKGIV 249
Query: 371 KELV 382
+ LV
Sbjct: 250 ELLV 253
Score = 40.8 bits (94), Expect = 0.003
Identities = 28/82 (34%), Positives = 46/82 (56%), Gaps = 1/82 (1%)
Frame = +2
Query: 143 AADKGHTEFVKLLLKNGAI-VDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNR 319
A+ +G TE V+ LL++ + V+ ++ G T L A + GY DV+ LLIE +++ D
Sbjct: 74 ASKQGQTENVEKLLRSNKVDVNYQDAYGKTALISAADKGYRDVIGLLIESGPNLDLQDEN 133
Query: 320 RMTCLMTAFKKGHIKVVKELVK 385
T L++A K ++ LVK
Sbjct: 134 GNTALISAAKIERGDIIDLLVK 155
>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
Length = 1881
Score = 77.8 bits (190), Expect = 2e-14
Identities = 57/179 (31%), Positives = 86/179 (48%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
RA +G TPL A + HV V +L+ A ++A V S T L +A+ GH VK LL
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDA--VTESGLTPLHVASFMGHLPIVKNLL 424
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIK 364
+ GA + N K +TPL +A G+ +V K L++ KA VN+ T L A + GH
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 365 VVKELVKYVTQFPSEHDCNKHLKSIKDGDKDIVNRCEACKEIILKAKERQECEAAKNAK 541
+VK L+ E++ N +L + + E E +L E++ +A K
Sbjct: 485 MVKLLL--------ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK 535
Score = 77.4 bits (189), Expect = 3e-14
Identities = 45/123 (36%), Positives = 72/123 (58%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGA 196
G+TPL AA +GH E+ +L++ A+ N S T L + A +GH +L+K+G
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 197 IVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKE 376
+VDA + G TPL +A + G I +VK L++++ADVN+ + L A ++GH +V
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 377 LVK 385
L+K
Sbjct: 753 LLK 755
Score = 72.4 bits (176), Expect = 8e-13
Identities = 62/183 (33%), Positives = 92/183 (50%), Gaps = 3/183 (1%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
KSGLTPL A +GHV V +LI V+A T L +A+ G+ + VK LL++
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKV- 367
A V+A+ K G +PL A G+ D+V LL++ A N + T L A + G+I V
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 368 -VKELVKYVTQFPSEHDCNKHLKSIKDGDKDIVNRCE-ACKEIILKAKERQECEAAKNAK 541
V ++V T F D KH S + +I++ E +E+I ER++ K
Sbjct: 784 DVLKVVTDETSFVLVSD--KHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEK 841
Query: 542 DLL 550
+LL
Sbjct: 842 ELL 844
Score = 72.0 bits (175), Expect = 1e-12
Identities = 49/127 (38%), Positives = 67/127 (52%)
Frame = +2
Query: 8 AKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLK 187
A +G TPL AA Q VEV R L+ NA V T L +AA +GH E V LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLS 656
Query: 188 NGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKV 367
A + NK G TPL L G++ V +LI++ V+++ T L A G+IK+
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 368 VKELVKY 388
VK L+++
Sbjct: 717 VKFLLQH 723
Score = 69.7 bits (169), Expect = 5e-12
Identities = 40/127 (31%), Positives = 71/127 (55%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
+ K+GL+P+ AA H++ R+L+ A+++ + T L +AA GH K+LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIK 364
GA ++R G TPL +AC ++ V++LL++ A +++ +T L A GH+
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418
Query: 365 VVKELVK 385
+VK L++
Sbjct: 419 IVKNLLQ 425
Score = 69.3 bits (168), Expect = 7e-12
Identities = 44/129 (34%), Positives = 72/129 (55%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
++GL L A+ +GHV++ L++ ++ T L IAA G E V+ L+
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
GA V+A+++KG TPL++A +++VVK L+E A+ N + T L A ++GH VV
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 371 KELVKYVTQ 397
L+ Y T+
Sbjct: 161 AHLINYGTK 169
Score = 69.3 bits (168), Expect = 7e-12
Identities = 45/121 (37%), Positives = 62/121 (51%)
Frame = +2
Query: 23 TPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAIV 202
TPL AA GH EV + L+ A VNA +T L AA GHT VKLLL+N A
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKA--KDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 203 DARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKELV 382
+ G TPL +A G+++ V L+E +A + T L A K G ++V + L+
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 383 K 385
+
Sbjct: 557 E 557
Score = 66.6 bits (161), Expect = 5e-11
Identities = 38/127 (29%), Positives = 71/127 (55%)
Frame = +2
Query: 8 AKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLK 187
+K+G TPL AA ++ V ++L+N A VN P + T L IA+ +G+ V+LLL
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP--QNGITPLHIASRRGNVIMVRLLLD 260
Query: 188 NGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKV 367
GA ++ + K TPL A G++ + ++L+++ A + + ++ + A + H+
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 368 VKELVKY 388
V+ L++Y
Sbjct: 321 VRLLLQY 327
Score = 65.5 bits (158), Expect = 1e-10
Identities = 45/126 (35%), Positives = 67/126 (53%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
+AK TPL AA GH + ++L+ +A+ N A ++ T L IAA +GH E V LL
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT--TAGHTPLHIAAREGHVETVLALL 523
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIK 364
+ A KKG TPL +A G + V +LL+E A N++ +T L A ++
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583
Query: 365 VVKELV 382
+VK L+
Sbjct: 584 IVKLLL 589
Score = 60.5 bits (145), Expect = 3e-09
Identities = 40/124 (32%), Positives = 61/124 (49%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
K G TPL AA G V V +L+ A NAA + T L +A + + VKLLL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG--KNGLTPLHVAVHHNNLDIVKLLLPR 591
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
G + G TPL +A ++V + L++Y N+ + +T L A ++GH ++V
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651
Query: 371 KELV 382
L+
Sbjct: 652 ALLL 655
Score = 58.2 bits (139), Expect = 2e-08
Identities = 42/125 (33%), Positives = 63/125 (50%)
Frame = +2
Query: 14 SGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNG 193
+G TPL AA +GHVE L+ A + A + T L +AA G +LLL+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 194 AIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVK 373
A +A K G TPL +A + +D+VKLL+ +S T L A K+ ++V +
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619
Query: 374 ELVKY 388
L++Y
Sbjct: 620 SLLQY 624
Score = 51.2 bits (121), Expect = 2e-06
Identities = 42/153 (27%), Positives = 69/153 (45%), Gaps = 27/153 (17%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVN----------AAPVPSSRETV------- 133
+++ G TPL AA + H+EV + L+ A+ N A + E V
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 134 ----------LIIAADKGHTEFVKLLLKNGAIVDARNKKGDTPLWLACNGGYIDVVKLLI 283
L IAA T +LL+N D +K G TPL +A + ++V +LL+
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 284 EYKADVNSSDNRRMTCLMTAFKKGHIKVVKELV 382
A VN + +T L A ++G++ +V+ L+
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Score = 51.2 bits (121), Expect = 2e-06
Identities = 41/153 (26%), Positives = 64/153 (41%), Gaps = 27/153 (17%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASA---------------------------DVNAAP 109
+ G TPL A QGH V LIN D N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 110 VPSSRETVLIIAADKGHTEFVKLLLKNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEY 289
+ + T L IAA + +LLL GA V+ + G TPL +A G + +V+LL++
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 290 KADVNSSDNRRMTCLMTAFKKGHIKVVKELVKY 388
A + + +T L A + GH+++ + L+ +
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
Score = 39.7 bits (91), Expect = 0.006
Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 3/111 (2%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
+ K G +PL +AA QGH ++ V LLL
Sbjct: 730 KTKLGYSPLHQAAQQGHTDI-----------------------------------VTLLL 754
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYI---DVVKLLIEYKADVNSSDNRRMT 328
KNGA + + G TPL +A GYI DV+K++ + + V SD RM+
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMS 805
>sp|Q59H18|TNI3K_HUMAN Serine/threonine-protein kinase TNNI3K (TNNI3-interacting kinase)
(Cardiac ankyrin repeat kinase)
Length = 936
Score = 75.9 bits (185), Expect = 7e-14
Identities = 62/166 (37%), Positives = 85/166 (51%), Gaps = 7/166 (4%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGA 196
GLT L A GH+E +L+ A+VN T L IAA GH + +LLLK GA
Sbjct: 235 GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFF--TPLHIAAYYGHEQVTRLLLKFGA 292
Query: 197 IVDARNKKGDTPLWLACNGGYIDVVKLLIEY--KADVNSSDNRRMTCLMTAFKKGHIKVV 370
V+ + GD PL LA G++++ KLL+E KADVN+ DN L + GH
Sbjct: 293 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH---- 348
Query: 371 KELVKYVTQFPSEHDCNKHLKSIKDGDKDIVNRC-----EACKEII 493
++VKY+ Q S+ + H+ +I GD + C E KEII
Sbjct: 349 HDIVKYLLQ--SDLEVQPHVVNIY-GDTPLHLACYNGKFEVAKEII 391
Score = 59.3 bits (142), Expect = 7e-09
Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 11/155 (7%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHT-EFVKLLLKNG 193
G TPL A G EV + +I S + ET A G + + VK LL
Sbjct: 371 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 430
Query: 194 AI-VDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVN---------SSDNRRMTCLMTA 343
I ++ + + G T L AC G+I +V+ L++ AD+N S + TCLM A
Sbjct: 431 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWA 490
Query: 344 FKKGHIKVVKELVKYVTQFPSEHDCNKHLKSIKDG 448
++KGH +V L+K+ + E CN++ + DG
Sbjct: 491 YEKGHDAIV-TLLKHYKRPQDELPCNEYSQPGGDG 524
Score = 53.9 bits (128), Expect = 3e-07
Identities = 40/125 (32%), Positives = 65/125 (52%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
++G T L A + + E+ L+++ AD+ V T L IA GH E +LL++
Sbjct: 200 RNGFTALHLAVYKDNAELITSLLHSGADIQQ--VGYGGLTALHIATIAGHLEAADVLLQH 257
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
GA V+ ++ TPL +A G+ V +LL+++ ADVN S L A KG + +
Sbjct: 258 GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA 317
Query: 371 KELVK 385
K L++
Sbjct: 318 KLLME 322
Score = 44.7 bits (104), Expect = 2e-04
Identities = 37/125 (29%), Positives = 49/125 (39%), Gaps = 37/125 (29%)
Frame = +2
Query: 23 TPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAIV 202
TPL AA GH +V R+L+ ADVN + R L +A+ KG KLL++ G+
Sbjct: 270 TPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRP--LHLASAKGFLNIAKLLMEEGSKA 327
Query: 203 DAR-------------------------------------NKKGDTPLWLACNGGYIDVV 271
D N GDTPL LAC G +V
Sbjct: 328 DVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVA 387
Query: 272 KLLIE 286
K +I+
Sbjct: 388 KEIIQ 392
Score = 37.4 bits (85), Expect = 0.029
Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 7/67 (10%)
Frame = +2
Query: 2 HRAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSR-------ETVLIIAADKGH 160
H+ + G T L A GH+ + + L++ AD+N SR +T L+ A +KGH
Sbjct: 436 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 495
Query: 161 TEFVKLL 181
V LL
Sbjct: 496 DAIVTLL 502
>sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G)
Length = 4377
Score = 75.1 bits (183), Expect = 1e-13
Identities = 47/129 (36%), Positives = 77/129 (59%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
++GL L A+ +GHVEV L+ A+V+AA + T L IA+ G E VK+L+ N
Sbjct: 72 QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGN--TALHIASLAGQAEVVKVLVTN 129
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
GA V+A+++ G TPL++A +++VVK L++ A + + T L A ++GH +VV
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVV 189
Query: 371 KELVKYVTQ 397
L++ T+
Sbjct: 190 SLLLENDTK 198
Score = 71.2 bits (173), Expect = 2e-12
Identities = 40/125 (32%), Positives = 70/125 (56%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
+ G+ + AA +GHV++ +L+ +A+VN + S T L +AA + ++L+
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSN--KSGLTPLHLAAQEDRVNVAEVLVNQ 719
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
GA VDA+ K G TPL + C+ G I +V L+++ A VN+ T L A ++GH ++
Sbjct: 720 GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHII 779
Query: 371 KELVK 385
L++
Sbjct: 780 NVLLQ 784
Score = 70.1 bits (170), Expect = 4e-12
Identities = 45/144 (31%), Positives = 78/144 (54%)
Frame = +2
Query: 8 AKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLK 187
+KSG TPL AA G++ V +L+N +A V+ + T L +A+ +G+ VKLLL
Sbjct: 232 SKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA--RNDITPLHVASKRGNANMVKLLLD 289
Query: 188 NGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKV 367
GA +DA+ + G TPL G+ VV++L++ A + S ++ L A + H+
Sbjct: 290 RGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNC 349
Query: 368 VKELVKYVTQFPSEHDCNKHLKSI 439
V+ L+++ P + N +L ++
Sbjct: 350 VQLLLQH--NVPVDDVTNDYLTAL 371
Score = 67.8 bits (164), Expect = 2e-11
Identities = 44/124 (35%), Positives = 64/124 (51%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
K G TPL AA G +EV +L+ SA +AA S T L +AA + + LLL
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG--KSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
GA A K G TPL +A +D+ L+EY AD N+ + + + A ++GH+ +V
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680
Query: 371 KELV 382
L+
Sbjct: 681 SLLL 684
Score = 67.4 bits (163), Expect = 3e-11
Identities = 43/126 (34%), Positives = 68/126 (53%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
+SGLTP+ AA GHV + L++ A N V ET L +AA G E V+ L+++
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG--ETALHMAARSGQAEVVRYLVQD 488
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
GA V+A+ K TPL ++ G D+V+ L++ A N++ T L + ++GH V
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
Query: 371 KELVKY 388
L+ +
Sbjct: 549 AFLLDH 554
Score = 67.4 bits (163), Expect = 3e-11
Identities = 43/127 (33%), Positives = 66/127 (51%)
Frame = +2
Query: 8 AKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLK 187
AK+G TPL AA + +++ L+ AD NA V + +AA +GH + V LLL
Sbjct: 628 AKNGYTPLHIAAKKNQMDIATTLLEYGADANA--VTRQGIASVHLAAQEGHVDMVSLLLG 685
Query: 188 NGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKV 367
A V+ NK G TPL LA ++V ++L+ A V++ T L G+IK+
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI 745
Query: 368 VKELVKY 388
V L+++
Sbjct: 746 VNFLLQH 752
Score = 66.6 bits (161), Expect = 5e-11
Identities = 42/122 (34%), Positives = 70/122 (57%)
Frame = +2
Query: 20 LTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAI 199
LT L AA GH +V ++L++ A+ NA + T L IA K + ++LLLK+GA
Sbjct: 368 LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGF--TPLHIACKKNRIKVMELLLKHGAS 425
Query: 200 VDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKEL 379
+ A + G TP+ +A G++++V L+ + A N+++ R T L A + G +VV+ L
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 380 VK 385
V+
Sbjct: 486 VQ 487
Score = 66.2 bits (160), Expect = 6e-11
Identities = 42/117 (35%), Positives = 62/117 (52%)
Frame = +2
Query: 32 MEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAIVDAR 211
+ AA GH+E I D+N + L +A+ +GH E V LL+ A VDA
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICN--QNGLNALHLASKEGHVEVVSELLQREANVDAA 103
Query: 212 NKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKELV 382
KKG+T L +A G +VVK+L+ A+VN+ T L A ++ H++VVK L+
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLL 160
Score = 65.5 bits (158), Expect = 1e-10
Identities = 39/127 (30%), Positives = 72/127 (56%), Gaps = 2/127 (1%)
Frame = +2
Query: 8 AKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRE--TVLIIAADKGHTEFVKLL 181
A++ +TPL A+ +G+ + ++L++ A ++A +R+ T L A GH + V++L
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDA----KTRDGLTPLHCGARSGHEQVVEML 320
Query: 182 LKNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHI 361
L A + ++ K G +PL +A G +++ V+LL+++ V+ N +T L A GH
Sbjct: 321 LDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHY 380
Query: 362 KVVKELV 382
KV K L+
Sbjct: 381 KVAKVLL 387
Score = 62.8 bits (151), Expect = 7e-10
Identities = 38/128 (29%), Positives = 68/128 (53%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
+ K+GL+PL A H+ ++L+ + V+ V + T L +AA GH + K+LL
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD--DVTNDYLTALHVAAHCGHYKVAKVLL 387
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIK 364
A +A+ G TPL +AC I V++LL+++ A + + +T + A GH+
Sbjct: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447
Query: 365 VVKELVKY 388
+V +L+ +
Sbjct: 448 IVSQLMHH 455
Score = 60.1 bits (144), Expect = 4e-09
Identities = 37/127 (29%), Positives = 65/127 (51%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
+A +G TPL A + ++V +L+ A + A V S T + +AA GH V L+
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQA--VTESGLTPIHVAAFMGHVNIVSQLM 453
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIK 364
+GA + N +G+T L +A G +VV+ L++ A V + T L + + G
Sbjct: 454 HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 513
Query: 365 VVKELVK 385
+V++L++
Sbjct: 514 IVQQLLQ 520
Score = 59.7 bits (143), Expect = 6e-09
Identities = 43/124 (34%), Positives = 61/124 (49%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
+ G TPL A QGH +V +L+ R L IAA K T+ LLL+N
Sbjct: 171 EDGFTPLAVALQQGHDQVVSLLLENDTKGKV------RLPALHIAARKDDTKAAALLLQN 224
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
D +K G TPL +A + G I+V LL+ A V+ + +T L A K+G+ +V
Sbjct: 225 DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMV 284
Query: 371 KELV 382
K L+
Sbjct: 285 KLLL 288
Score = 57.4 bits (137), Expect = 3e-08
Identities = 43/131 (32%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRE---TVLIIAADKGHTEFVK 175
+ + GLTPL A GH +V +L++ AAP+ S + + L +A H V+
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLD-----RAAPILSKTKNGLSPLHMATQGDHLNCVQ 351
Query: 176 LLLKNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKG 355
LLL++ VD T L +A + G+ V K+L++ KA+ N+ T L A KK
Sbjct: 352 LLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKN 411
Query: 356 HIKVVKELVKY 388
IKV++ L+K+
Sbjct: 412 RIKVMELLLKH 422
Score = 56.6 bits (135), Expect = 5e-08
Identities = 39/121 (32%), Positives = 62/121 (51%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
+AK TPL +A G ++ + L+ A NAA +S T L ++A +GH + LL
Sbjct: 495 KAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT--TSGYTPLHLSAREGHEDVAAFLL 552
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIK 364
+GA + KKG TPL +A G ++V LL++ A +++ +T L A + K
Sbjct: 553 DHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQK 612
Query: 365 V 367
V
Sbjct: 613 V 613
Score = 55.8 bits (133), Expect = 8e-08
Identities = 40/125 (32%), Positives = 60/125 (48%)
Frame = +2
Query: 14 SGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNG 193
SG TPL +A +GH +V L++ A ++ T L +AA G E LLL+
Sbjct: 531 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGF--TPLHVAAKYGKLEVANLLLQKS 588
Query: 194 AIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVK 373
A DA K G TPL +A + V LL++ A +++ T L A KK + +
Sbjct: 589 ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIAT 648
Query: 374 ELVKY 388
L++Y
Sbjct: 649 TLLEY 653
Score = 51.2 bits (121), Expect = 2e-06
Identities = 33/92 (35%), Positives = 47/92 (51%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
+ K G TPL G++++ L+ SA VNA + T L AA +GHT + +LL
Sbjct: 726 QTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT--KNGYTPLHQAAQQGHTHIINVLL 783
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLL 280
+N A + G+T L +A GYI VV L
Sbjct: 784 QNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 31.2 bits (69), Expect = 2.1
Identities = 18/61 (29%), Positives = 30/61 (49%), Gaps = 2/61 (3%)
Frame = +2
Query: 209 RNKKGDT--PLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKELV 382
R KK D A G+++ I+ D+N + + L A K+GH++VV EL+
Sbjct: 35 RKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELL 94
Query: 383 K 385
+
Sbjct: 95 Q 95
>sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin)
Length = 1862
Score = 74.7 bits (182), Expect = 2e-13
Identities = 44/123 (35%), Positives = 71/123 (57%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGA 196
G+TPL AA +GH E+ +L++ A+ N S T L + + +GH +L+K+G
Sbjct: 631 GVTPLHLAAQEGHTEMVALLLSKQANGNLGN--KSGLTPLHLVSQEGHVLVADVLIKHGV 688
Query: 197 IVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKE 376
VDA + G TPL +A + G I +VK L++++ADVN+ + L A ++GH +V
Sbjct: 689 TVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 748
Query: 377 LVK 385
L+K
Sbjct: 749 LLK 751
Score = 74.3 bits (181), Expect = 2e-13
Identities = 48/125 (38%), Positives = 68/125 (54%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
+SGLTPL A+ GH+ + + L+ A N + V ET L +AA GHTE K LL+N
Sbjct: 398 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV--ETPLHMAARAGHTEVAKYLLQN 455
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
A +A+ K TPL A G+ +VKLL+E A N + T L TA ++GH+
Sbjct: 456 KAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTA 515
Query: 371 KELVK 385
L++
Sbjct: 516 LALLE 520
Score = 73.9 bits (180), Expect = 3e-13
Identities = 46/127 (36%), Positives = 68/127 (53%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
RA +G TPL A + H+ V +L+ A ++A V S T L +A+ GH VK LL
Sbjct: 363 RALNGFTPLHIACKKNHIRVMELLLKTGASIDA--VTESGLTPLHVASFMGHLPIVKNLL 420
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIK 364
+ GA + N K +TPL +A G+ +V K L++ KA N+ T L A + GH
Sbjct: 421 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTG 480
Query: 365 VVKELVK 385
+VK L++
Sbjct: 481 MVKLLLE 487
Score = 72.8 bits (177), Expect = 6e-13
Identities = 49/127 (38%), Positives = 68/127 (53%)
Frame = +2
Query: 8 AKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLK 187
A +G TPL AA Q +EV R L+ NA V T L +AA +GHTE V LLL
Sbjct: 595 AWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGV--TPLHLAAQEGHTEMVALLLS 652
Query: 188 NGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKV 367
A + NK G TPL L G++ V +LI++ V+++ T L A G+IK+
Sbjct: 653 KQANGNLGNKSGLTPLHLVSQEGHVLVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKL 712
Query: 368 VKELVKY 388
VK L+++
Sbjct: 713 VKFLLQH 719
Score = 70.1 bits (170), Expect = 4e-12
Identities = 46/122 (37%), Positives = 68/122 (55%)
Frame = +2
Query: 20 LTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAI 199
LTPL AA GH V ++L++ A N+ + T L IA K H ++LLLK GA
Sbjct: 335 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHIRVMELLLKTGAS 392
Query: 200 VDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKEL 379
+DA + G TPL +A G++ +VK L++ A N S+ + T L A + GH +V K L
Sbjct: 393 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 452
Query: 380 VK 385
++
Sbjct: 453 LQ 454
Score = 70.1 bits (170), Expect = 4e-12
Identities = 59/182 (32%), Positives = 92/182 (50%), Gaps = 2/182 (1%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
KSGLTPL + +GHV V +LI V+A T L +A+ G+ + VK LL++
Sbjct: 662 KSGLTPLHLVSQEGHVLVADVLIKHGVTVDATT--RMGYTPLHVASHYGNIKLVKFLLQH 719
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
A V+A+ K G +PL A G+ D+V LL++ A N + T L A + G+I V
Sbjct: 720 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISVT 779
Query: 371 KELVKYVTQFPS-EHDCNKHLKSIKDGDKDIVNRCE-ACKEIILKAKERQECEAAKNAKD 544
+++K VT S +KH S + +I++ E E++ ER++ K+
Sbjct: 780 -DVLKVVTDETSVVLVSDKHRMSYPETVDEILDVSEDEGDELVGSKAERRDSRDVGEEKE 838
Query: 545 LL 550
LL
Sbjct: 839 LL 840
Score = 69.3 bits (168), Expect = 7e-12
Identities = 44/129 (34%), Positives = 72/129 (55%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
++GL L A+ +GHV++ L++ ++ T L IAA G E V+ L+
Sbjct: 39 QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 96
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
GA V+A+++KG TPL++A +++VVK L+E A+ N + T L A ++GH VV
Sbjct: 97 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 156
Query: 371 KELVKYVTQ 397
L+ Y T+
Sbjct: 157 AHLINYGTK 165
Score = 68.2 bits (165), Expect = 2e-11
Identities = 44/122 (36%), Positives = 61/122 (50%)
Frame = +2
Query: 23 TPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAIV 202
TPL AA GH EV + L+ A NA +T L AA GHT VKLLL+NGA
Sbjct: 435 TPLHMAARAGHTEVAKYLLQNKAKANAKA--KDDQTPLHCAARIGHTGMVKLLLENGASP 492
Query: 203 DARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKELV 382
+ G TPL A G++D L+E +A + T L A K G +++ + L+
Sbjct: 493 NLATTAGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLL 552
Query: 383 KY 388
++
Sbjct: 553 EH 554
Score = 67.8 bits (164), Expect = 2e-11
Identities = 39/127 (30%), Positives = 71/127 (55%)
Frame = +2
Query: 8 AKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLK 187
+K+G TPL AA ++ V ++L+N A VN P + T L IA+ +G+ V+LLL
Sbjct: 199 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP--QNGITPLHIASRRGNVIMVRLLLD 256
Query: 188 NGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKV 367
GA ++ R K TPL A G++ + ++L+++ A + + ++ + A + H+
Sbjct: 257 RGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 316
Query: 368 VKELVKY 388
V+ L++Y
Sbjct: 317 VRLLLQY 323
Score = 63.5 bits (153), Expect = 4e-10
Identities = 45/127 (35%), Positives = 67/127 (52%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
R K LTPL AA GHV + IL++ A + A + + + +AA H + V+LLL
Sbjct: 264 RTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT--KNGLSPIHMAAQGDHLDCVRLLL 321
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIK 364
+ A +D TPL +A + G+ V K+L++ A NS T L A KK HI+
Sbjct: 322 QYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIR 381
Query: 365 VVKELVK 385
V++ L+K
Sbjct: 382 VMELLLK 388
Score = 60.1 bits (144), Expect = 4e-09
Identities = 42/125 (33%), Positives = 64/125 (51%)
Frame = +2
Query: 14 SGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNG 193
+G TPL AA +GHV+ L+ A + A + T L +AA G +LLL++
Sbjct: 498 AGHTPLHTAAREGHVDTALALLEKEA--SQACMTKKGFTPLHVAAKYGKVRLAELLLEHD 555
Query: 194 AIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVK 373
A +A K G TPL +A + +D+VKLL+ +S T L A K+ I+V +
Sbjct: 556 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVAR 615
Query: 374 ELVKY 388
L++Y
Sbjct: 616 SLLQY 620
Score = 59.7 bits (143), Expect = 6e-09
Identities = 41/126 (32%), Positives = 64/126 (50%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
+AK TPL AA GH + ++L+ A N A ++ T L AA +GH + LL
Sbjct: 462 KAKDDQTPLHCAARIGHTGMVKLLLENGASPNLA--TTAGHTPLHTAAREGHVDTALALL 519
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIK 364
+ A KKG TPL +A G + + +LL+E+ A N++ +T L A ++
Sbjct: 520 EKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLD 579
Query: 365 VVKELV 382
+VK L+
Sbjct: 580 IVKLLL 585
Score = 59.3 bits (142), Expect = 7e-09
Identities = 40/124 (32%), Positives = 61/124 (49%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
K G TPL AA G V + +L+ A NAA + T L +A + + VKLLL
Sbjct: 530 KKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAG--KNGLTPLHVAVHHNNLDIVKLLLPR 587
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
G + G TPL +A I+V + L++Y N+ + +T L A ++GH ++V
Sbjct: 588 GGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMV 647
Query: 371 KELV 382
L+
Sbjct: 648 ALLL 651
Score = 51.2 bits (121), Expect = 2e-06
Identities = 42/153 (27%), Positives = 69/153 (45%), Gaps = 27/153 (17%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVN----------AAPVPSSRETV------- 133
+++ G TPL AA + H+EV + L+ A+ N A + E V
Sbjct: 103 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 162
Query: 134 ----------LIIAADKGHTEFVKLLLKNGAIVDARNKKGDTPLWLACNGGYIDVVKLLI 283
L IAA T +LL+N D +K G TPL +A + ++V +LL+
Sbjct: 163 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 222
Query: 284 EYKADVNSSDNRRMTCLMTAFKKGHIKVVKELV 382
A VN + +T L A ++G++ +V+ L+
Sbjct: 223 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 255
Score = 50.8 bits (120), Expect = 3e-06
Identities = 41/153 (26%), Positives = 64/153 (41%), Gaps = 27/153 (17%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASA---------------------------DVNAAP 109
+ G TPL A QGH V LIN D N
Sbjct: 138 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 197
Query: 110 VPSSRETVLIIAADKGHTEFVKLLLKNGAIVDARNKKGDTPLWLACNGGYIDVVKLLIEY 289
+ + T L IAA + +LLL GA V+ + G TPL +A G + +V+LL++
Sbjct: 198 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 257
Query: 290 KADVNSSDNRRMTCLMTAFKKGHIKVVKELVKY 388
A + + +T L A + GH+++ + L+ +
Sbjct: 258 GAQIETRTKDELTPLHCAARNGHVRISEILLDH 290
Score = 40.0 bits (92), Expect = 0.005
Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 3/111 (2%)
Frame = +2
Query: 5 RAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLL 184
+ K G +PL +AA QGH ++ V LLL
Sbjct: 726 KTKLGYSPLHQAAQQGHTDI-----------------------------------VTLLL 750
Query: 185 KNGAIVDARNKKGDTPLWLACNGGYI---DVVKLLIEYKADVNSSDNRRMT 328
KNGA + + G TPL +A GYI DV+K++ + + V SD RM+
Sbjct: 751 KNGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETSVVLVSDKHRMS 801
>sp|Q5RF15|TNI3K_PONPY Serine/threonine-protein kinase TNNI3K (TNNI3-interacting kinase)
Length = 618
Score = 74.7 bits (182), Expect = 2e-13
Identities = 61/166 (36%), Positives = 85/166 (51%), Gaps = 7/166 (4%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGA 196
GLT L A GH+E +L+ A+VN T L IAA GH + +LLLK GA
Sbjct: 134 GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFF--TPLHIAAYYGHEQVTRLLLKFGA 191
Query: 197 IVDARNKKGDTPLWLACNGGYIDVVKLLIEY--KADVNSSDNRRMTCLMTAFKKGHIKVV 370
V+ + GD PL LA G++++ KLL+E KADVN+ DN L + GH
Sbjct: 192 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH---- 247
Query: 371 KELVKYVTQFPSEHDCNKHLKSIKDGDKDIVNRC-----EACKEII 493
++VKY+ Q ++ + H+ +I GD + C E KEII
Sbjct: 248 HDIVKYLLQ--NDLEVQPHVVNIY-GDTPLHLACYNGKFEVAKEII 290
Score = 59.7 bits (143), Expect = 6e-09
Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 11/155 (7%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHT-EFVKLLLKNG 193
G TPL A G EV + +I S + ET A G + + VK LL
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 329
Query: 194 AI-VDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVN---------SSDNRRMTCLMTA 343
I ++ + + G T L AC G+I +V+ L++ AD+N S + TCLM A
Sbjct: 330 VININHQGRDGHTGLHSACYHGHIHLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWA 389
Query: 344 FKKGHIKVVKELVKYVTQFPSEHDCNKHLKSIKDG 448
++KGH +V L+K+ + E CN++ + DG
Sbjct: 390 YEKGHDAIV-TLLKHYKRPQDELPCNEYSQPGGDG 423
Score = 53.5 bits (127), Expect = 4e-07
Identities = 40/125 (32%), Positives = 64/125 (51%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
++G T L A + + E+ L++ AD+ V T L IA GH E +LL++
Sbjct: 99 RNGFTALHLAVYKDNAELITSLLHGGADIQQ--VGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
GA V+ ++ TPL +A G+ V +LL+++ ADVN S L A KG + +
Sbjct: 157 GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA 216
Query: 371 KELVK 385
K L++
Sbjct: 217 KLLME 221
Score = 45.8 bits (107), Expect = 8e-05
Identities = 33/94 (35%), Positives = 49/94 (52%), Gaps = 4/94 (4%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILIN--ASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
G PL A+++G + + ++L+ + ADVNA + L + GH + VK LL+N
Sbjct: 200 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQD--NEDHVPLHFCSRFGHHDIVKYLLQN 257
Query: 191 GAIVDAR--NKKGDTPLWLACNGGYIDVVKLLIE 286
V N GDTPL LAC G +V K +I+
Sbjct: 258 DLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQ 291
Score = 37.4 bits (85), Expect = 0.029
Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 7/67 (10%)
Frame = +2
Query: 2 HRAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSR-------ETVLIIAADKGH 160
H+ + G T L A GH+ + + L++ AD+N SR +T L+ A +KGH
Sbjct: 335 HQGRDGHTGLHSACYHGHIHLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 394
Query: 161 TEFVKLL 181
V LL
Sbjct: 395 DAIVTLL 401
>sp|Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (Histone
H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic
histone-lysine N-methyltransferase 1) (Eu-HMTase1)
(G9a-like protein 1) (GLP1)
Length = 1267
Score = 74.3 bits (181), Expect = 2e-13
Identities = 47/121 (38%), Positives = 68/121 (56%), Gaps = 1/121 (0%)
Frame = +2
Query: 23 TPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAI- 199
TPLMEAA H+E + LI A A V+ P + T L +AA KGH E V+ LL NG +
Sbjct: 777 TPLMEAAENNHLEAVKYLIKAGALVD--PKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMD 834
Query: 200 VDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKEL 379
V+ ++ G TP+ A ++D+VKLL+ +D+N DN CL A G + + + L
Sbjct: 835 VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 894
Query: 380 V 382
+
Sbjct: 895 L 895
Score = 73.2 bits (178), Expect = 5e-13
Identities = 53/168 (31%), Positives = 88/168 (52%), Gaps = 7/168 (4%)
Frame = +2
Query: 23 TPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAIV 202
+PL AA GHV++ +L+ A A+++ + T L+ AA+ H E VK L+K GA+V
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTC--SEDQRTPLMEAAENNHLEAVKYLIKAGALV 801
Query: 203 DARNKKGDTPLWLACNGGYIDVVK-LLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKEL 379
D ++ +G T L LA G+ +VV+ LL + DVN D+ T ++ A + H+ +VK L
Sbjct: 802 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 861
Query: 380 VKYVTQFPSEHDCNKHLKSIKDGDKDI------VNRCEACKEIILKAK 505
+ + +I+D +++I + C EI+L AK
Sbjct: 862 LSKGSDI-----------NIRDNEENICLHWAAFSGCVDIAEILLAAK 898
Score = 60.8 bits (146), Expect = 2e-09
Identities = 36/115 (31%), Positives = 61/115 (53%)
Frame = +2
Query: 38 AASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAIVDARNK 217
+A QG ++ +++ D N ++ + L AA+ GH + +L++ GA +D ++
Sbjct: 714 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 773
Query: 218 KGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVVKELV 382
TPL A +++ VK LI+ A V+ D TCL A KKGH +VV+ L+
Sbjct: 774 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 828
Score = 48.1 bits (113), Expect = 2e-05
Identities = 32/98 (32%), Positives = 52/98 (53%), Gaps = 1/98 (1%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILI-NASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNG 193
G T L AA +GH EV + L+ N DVN T +I A + H + VKLLL G
Sbjct: 808 GSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQD--DGGWTPMIWATEYKHVDLVKLLLSKG 865
Query: 194 AIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNS 307
+ ++ R+ + + L A G +D+ ++L+ K D+++
Sbjct: 866 SDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHA 903
Score = 42.7 bits (99), Expect = 7e-04
Identities = 25/88 (28%), Positives = 50/88 (56%), Gaps = 4/88 (4%)
Frame = +2
Query: 134 LIIAADKGHTEFVKLLLKNGAI----VDARNKKGDTPLWLACNGGYIDVVKLLIEYKADV 301
L +A +G + V L+L +G ++ +NK+ +PL A G++D+ +L++ A++
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR--SPLHAAAEAGHVDICHMLVQAGANI 768
Query: 302 NSSDNRRMTCLMTAFKKGHIKVVKELVK 385
++ + T LM A + H++ VK L+K
Sbjct: 769 DTCSEDQRTPLMEAAENNHLEAVKYLIK 796
Score = 38.1 bits (87), Expect = 0.017
Identities = 24/69 (34%), Positives = 38/69 (55%)
Frame = +2
Query: 38 AASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGAIVDARNK 217
AA G V++ IL+ A D++A + ++ L IAA + + V L L + V +NK
Sbjct: 882 AAFSGCVDIAEILLAAKCDLHAVNIHG--DSPLHIAARENRYDCVVLFLSRDSDVTLKNK 939
Query: 218 KGDTPLWLA 244
+G+TPL A
Sbjct: 940 EGETPLQCA 948
>sp|Q5GIG6|TNI3K_MOUSE Serine/threonine-protein kinase TNNI3K (TNNI3-interacting kinase)
(Cardiac ankyrin repeat kinase)
Length = 834
Score = 73.6 bits (179), Expect = 4e-13
Identities = 60/165 (36%), Positives = 82/165 (49%), Gaps = 6/165 (3%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKNGA 196
GLT L AA GH E +L+ A+VN T L IAA GH + +LLK GA
Sbjct: 134 GLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFF--TPLHIAAYYGHEQVTSVLLKFGA 191
Query: 197 IVDARNKKGDTPLWLACNGGYIDVVKLLIE-YKADVNSSDNRRMTCLMTAFKKGHIKVVK 373
V+ + GD PL LA G+ ++VKLL+E KADVN+ DN L + GH +V
Sbjct: 192 DVNVSGEVGDRPLHLASAKGFFNIVKLLVEGNKADVNAQDNEDHVPLHFCSRFGHHNIVS 251
Query: 374 ELVKYVTQFPSEHDCNKHLKSIKDGDKDIVNRC-----EACKEII 493
L++ S+ + H+ +I GD + C E KEI+
Sbjct: 252 YLLQ------SDLEVQPHVINIY-GDTPLHLACYNGNFEVAKEIV 289
Score = 62.0 bits (149), Expect = 1e-09
Identities = 47/155 (30%), Positives = 76/155 (49%), Gaps = 11/155 (7%)
Frame = +2
Query: 17 GLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKG-HTEFVKLLLKNG 193
G TPL A G+ EV + +++ + + ET A G + + VK LL
Sbjct: 269 GDTPLHLACYNGNFEVAKEIVHVTGTESLTKENIFSETAFHSACTYGKNIDLVKFLLDQN 328
Query: 194 AI-VDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVN---------SSDNRRMTCLMTA 343
A+ ++ R + G T L AC G+I +V+ L++ AD+N S + TCLM A
Sbjct: 329 AVNINHRGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWA 388
Query: 344 FKKGHIKVVKELVKYVTQFPSEHDCNKHLKSIKDG 448
++KGH +V L+K+ + E CN++ + DG
Sbjct: 389 YEKGHDAIV-TLLKHYKRPQDELPCNEYSQPGGDG 422
Score = 56.6 bits (135), Expect = 5e-08
Identities = 43/125 (34%), Positives = 66/125 (52%)
Frame = +2
Query: 11 KSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSRETVLIIAADKGHTEFVKLLLKN 190
++G L A + +E+ L+++ ADV A T L IAA GH E V++LL++
Sbjct: 99 RNGFPALHLAVYKDSLELITSLLHSGADVQQAGYGGL--TALHIAAIAGHPEAVEVLLQH 156
Query: 191 GAIVDARNKKGDTPLWLACNGGYIDVVKLLIEYKADVNSSDNRRMTCLMTAFKKGHIKVV 370
GA V+ ++ TPL +A G+ V +L+++ ADVN S L A KG +V
Sbjct: 157 GANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIV 216
Query: 371 KELVK 385
K LV+
Sbjct: 217 KLLVE 221
Score = 38.9 bits (89), Expect = 0.010
Identities = 23/67 (34%), Positives = 33/67 (49%), Gaps = 7/67 (10%)
Frame = +2
Query: 2 HRAKSGLTPLMEAASQGHVEVGRILINASADVNAAPVPSSR-------ETVLIIAADKGH 160
HR + G T L A GH+ + + L++ AD+N SR +T L+ A +KGH
Sbjct: 334 HRGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 393
Query: 161 TEFVKLL 181
V LL
Sbjct: 394 DAIVTLL 400
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,455,289
Number of Sequences: 369166
Number of extensions: 1008253
Number of successful extensions: 5651
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3979
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5085
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4650991475
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)