Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_D15
(847 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P37276|DYHC_DROME Dynein heavy chain, cytosolic (DYHC) 277 3e-74
sp|Q9JHU4|DYHC_MOUSE Dynein heavy chain, cytosolic (DYHC) (... 270 3e-72
sp|P38650|DYHC_RAT Dynein heavy chain, cytosolic (DYHC) (Cy... 266 7e-71
sp|Q14204|DYHC_HUMAN Dynein heavy chain, cytosolic (DYHC) (... 266 7e-71
sp|Q19020|DYHC_CAEEL Dynein heavy chain, cytosolic (DYHC) 219 7e-57
sp|P34036|DYHC_DICDI Dynein heavy chain, cytosolic (DYHC) 186 7e-47
sp|Q27171|DYHC_PARTE Dynein heavy chain, cytosolic (DYHC) (... 162 8e-40
sp|P78716|DYHC_FUSSO Dynein heavy chain, cytosolic (DYHC) 61 4e-09
sp|P45443|DYHC_NEUCR Dynein heavy chain, cytosolic (DYHC) 59 1e-08
sp|Q9NYC9|DYH9_HUMAN Ciliary dynein heavy chain 9 (Axonemal... 57 6e-08
>sp|P37276|DYHC_DROME Dynein heavy chain, cytosolic (DYHC)
Length = 4639
Score = 277 bits (708), Expect = 3e-74
Identities = 149/289 (51%), Positives = 192/289 (66%), Gaps = 7/289 (2%)
Frame = +1
Query: 1 WIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEI---VVDQRKSK 171
WI L D QTPSWLGLPN+AEKVLLT G L+ +LKMQQ LEDD+E+ V DQ +
Sbjct: 4296 WIENLTDRQTPSWLGLPNNAEKVLLTTRGTDLVSKLLKMQQ-LEDDDELAYSVEDQSEQS 4354
Query: 172 RTIELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLL 351
D RP WM+ L+ S WL+LLPK + L+RT ENIKDP+YR FEREV SGS LL
Sbjct: 4355 AVGRGEDGRPSWMKTLHNSATAWLELLPKNLQVLKRTVENIKDPLYRYFEREVTSGSRLL 4414
Query: 352 LIVRKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFAD 531
V DL+D+ +C G KK TNHHRSM++ L +GIIP W +Y + +G TVIQWI DF++
Sbjct: 4415 QTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVPAGCTVIQWITDFSN 4474
Query: 532 RVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVE 711
RV+QL +S +GA L+ +WLGGL EAY TA RQ VAQ+N W+LEEL LDV
Sbjct: 4475 RVQQLQKVSQLVSQAGAKELQGFPVWLGGLLNPEAYITATRQCVAQANSWSLEELALDVT 4534
Query: 712 LGEG--KIDKNTCI--VTGLRLMGSEIVDSKTLKLSTTIYKDIDICRLK 846
+ + K D+ C VTGL+L G++ +++ L L++TI D+ + LK
Sbjct: 4535 ITDAGLKNDQKDCCFGVTGLKLQGAQCKNNELL-LASTIMMDLPVTILK 4582
>sp|Q9JHU4|DYHC_MOUSE Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain)
Length = 4644
Score = 270 bits (691), Expect = 3e-72
Identities = 135/285 (47%), Positives = 191/285 (67%), Gaps = 3/285 (1%)
Frame = +1
Query: 1 WIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTI 180
W+ LPD+QTPSWLGLPN+AE+VLLT G +I +LKMQ ++D+ + K RT
Sbjct: 4306 WVELLPDAQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKARTD 4365
Query: 181 ELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIV 360
D RP WMR L+ + WL L+P+ + PL+RT ENIKDP++R FEREV G+ LL V
Sbjct: 4366 STSDGRPAWMRTLHTTASNWLHLIPQTLSPLKRTVENIKDPLFRFFEREVKMGAKLLQDV 4425
Query: 361 RKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVK 540
R+DL D+ +VC G KK TN+ R+++ L KGI+P SW Y + +G+TVIQW+ DF++R+K
Sbjct: 4426 RQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIK 4485
Query: 541 QLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELGE 720
QL +IS A + GA L+++ + LGGLF+ EAY TA RQ VAQ+N W+LEEL L+V +
Sbjct: 4486 QLQNISQAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTA 4545
Query: 721 GK---IDKNTCIVTGLRLMGSEIVDSKTLKLSTTIYKDIDICRLK 846
+ +D + VTGL+L G+ ++K L LS I + + +L+
Sbjct: 4546 SQSATLDACSFGVTGLKLQGATCSNNK-LSLSNAISTVLPLTQLR 4589
>sp|P38650|DYHC_RAT Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain)
(MAP 1C)
Length = 4644
Score = 266 bits (679), Expect = 7e-71
Identities = 134/285 (47%), Positives = 189/285 (66%), Gaps = 3/285 (1%)
Frame = +1
Query: 1 WIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTI 180
W+ LPD+QTPSWLGLPN+AE+VLLT G +I +LKMQ ++D+ + K RT
Sbjct: 4306 WVELLPDAQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTD 4365
Query: 181 ELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIV 360
D RP WMR L+ + WL L+P+ + PL+RT ENIKDP++R FEREV G+ LL V
Sbjct: 4366 FTSDGRPAWMRTLHTTASNWLHLIPQTLSPLKRTVENIKDPLFRFFEREVKMGAKLLQDV 4425
Query: 361 RKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVK 540
R+DL D+ +VC G KK TN+ R+++ L KGI+P SW Y + +G+TVIQW+ DF++R+K
Sbjct: 4426 RQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIK 4485
Query: 541 QLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELGE 720
QL +IS A GA L+++ + LG LF+ EAY TA RQ VAQ+N W+LEEL L+V +
Sbjct: 4486 QLQNISQAAAAGGAKELKNIHVCLGALFVPEAYITATRQYVAQANSWSLEELCLEVNVTA 4545
Query: 721 GK---IDKNTCIVTGLRLMGSEIVDSKTLKLSTTIYKDIDICRLK 846
+ +D + VTGL+L G+ ++K L LS I + + +L+
Sbjct: 4546 SQSTTLDACSFGVTGLKLQGATCSNNK-LSLSNAISTVLPLTQLR 4589
>sp|Q14204|DYHC_HUMAN Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain
1) (DHC1)
Length = 4646
Score = 266 bits (679), Expect = 7e-71
Identities = 134/285 (47%), Positives = 190/285 (66%), Gaps = 3/285 (1%)
Frame = +1
Query: 1 WIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTI 180
W+ LPD+QTPSWLGLPN+AE+VLLT G +I +LKMQ ++D+ + K RT
Sbjct: 4308 WVELLPDTQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTD 4367
Query: 181 ELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIV 360
D RP WMR L+ + WL L+P+ + L+RT ENIKDP++R FEREV G+ LL V
Sbjct: 4368 STSDGRPAWMRTLHTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDV 4427
Query: 361 RKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVK 540
R+DL D+ +VC G KK TN+ R+++ L KGI+P SW Y + +G+TVIQW+ DF++R+K
Sbjct: 4428 RQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIK 4487
Query: 541 QLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELGE 720
QL +IS A + GA L+++ + LGGLF+ EAY TA RQ VAQ+N W+LEEL L+V +
Sbjct: 4488 QLQNISLAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTT 4547
Query: 721 GK---IDKNTCIVTGLRLMGSEIVDSKTLKLSTTIYKDIDICRLK 846
+ +D + VTGL+L G+ ++K L LS I + + +L+
Sbjct: 4548 SQGATLDACSFGVTGLKLQGATCNNNK-LSLSNAISTALPLTQLR 4591
>sp|Q19020|DYHC_CAEEL Dynein heavy chain, cytosolic (DYHC)
Length = 4568
Score = 219 bits (558), Expect = 7e-57
Identities = 115/278 (41%), Positives = 168/278 (60%)
Frame = +1
Query: 1 WIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTI 180
W+ +L + Q P+WLGLPN+AEKVLLT G+S++ N+LK+ DEE+ ++ +
Sbjct: 4256 WVEELKNEQLPAWLGLPNNAEKVLLTKRGESMLRNMLKVT-----DEELAFNEDGKEEV- 4309
Query: 181 ELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIV 360
+P WM QL + + WLQLLPK ++ ++RT ENIKDP++R FEREVN GS LL +
Sbjct: 4310 -----KPQWMAQLGELAKQWLQLLPKEIVKMRRTVENIKDPLFRFFEREVNLGSQLLKDI 4364
Query: 361 RKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVK 540
R+DL +IS VC KK N R++ +L KG +P W +Y + +TV+ W+ D +R+K
Sbjct: 4365 RRDLNEISAVCRAEKKQNNETRALAASLQKGEVPTGWKRYTVpreVTVMDWMTDLNERLK 4424
Query: 541 QLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELGE 720
QLI I GA L+ WLGG F EAY TA RQ VAQ+N W+LE+L L + +G
Sbjct: 4425 QLIRI------GGADNLKRETFWLGGTFSPEAYITATRQQVAQANTWSLEQLNLHIHIGR 4478
Query: 721 GKIDKNTCIVTGLRLMGSEIVDSKTLKLSTTIYKDIDI 834
+ ++G+ + G++ V L+L + + DI
Sbjct: 4479 TD-STDVFRISGIDIRGAKSVGGNKLELCELVKSECDI 4515
>sp|P34036|DYHC_DICDI Dynein heavy chain, cytosolic (DYHC)
Length = 4725
Score = 186 bits (472), Expect = 7e-47
Identities = 109/289 (37%), Positives = 165/289 (57%), Gaps = 12/289 (4%)
Frame = +1
Query: 1 WIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTI 180
WI LP+ TP WLGLP +AE +LL+N + +I ++ KMQ + ED E+ V SK+
Sbjct: 4390 WIEALPEISTPIWLGLPENAESLLLSNKARKMINDLQKMQSSEEDGEDDQVSG-SSKKES 4448
Query: 181 ELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIV 360
S +L + W +LLPK + L+RTT+NIKDP++RCFERE+++G L+ +
Sbjct: 4449 SSSSSEDKGKAKLRATITEWTKLLPKPLKQLKRTTQNIKDPLFRCFEREISTGGKLVKKI 4508
Query: 361 RKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRVK 540
DL ++ E+ SG K TN+ RS+ T+++KGI+P W Y + +++ WI DF+ R++
Sbjct: 4509 TNDLANLLELISGNIKSTNYLRSLTTSISKGIVPKEWKWYSVPETISLSVWISDFSKRMQ 4568
Query: 541 QLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELGE 720
QL IS ++ S S+++WLGGL EAY TA RQ+ +Q N W+LE L L
Sbjct: 4569 QLSEISESSDYS------SIQVWLGGLLNPEAYITATRQSASQLNGWSLENLRLHAS-SL 4621
Query: 721 GKIDKN---TCIVTGLRLMGS---------EIVDSKTLKLSTTIYKDID 831
GKI + V G+ L G+ + S + ++T +KD D
Sbjct: 4622 GKISSEGGASFNVKGMALEGAVWNNDQLTPTDILSTPISIATLTWKDKD 4670
>sp|Q27171|DYHC_PARTE Dynein heavy chain, cytosolic (DYHC) (DHC08)
Length = 4540
Score = 162 bits (411), Expect = 8e-40
Identities = 87/269 (32%), Positives = 152/269 (56%), Gaps = 1/269 (0%)
Frame = +1
Query: 1 WIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDD-EEIVVDQRKSKRT 177
WI +LP +++P W GLP++ E+V L Q LI + +QQ E++ +I V K+++
Sbjct: 4209 WIEQLPKTESPEWSGLPSNVERVQRDQLTQKLITKVQNLQQEGEEEITQIEVQTEKTQKK 4268
Query: 178 IELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLI 357
+ W++ L + + + +LP + PL+RT ++I DP++R +RE+ S LL
Sbjct: 4269 DNKKSDQVQWLQDLLEKVEKFKAILPNKISPLERTADSINDPLFRFLDREITVASKLLKA 4328
Query: 358 VRKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIHDFADRV 537
VR+++E++ ++ G TN R + ++ I+P W KY + + + + W+ DF R+
Sbjct: 4329 VRQNIEELIQLAQGKILATNILRQLAKDVFNNIVPAQWNKYNVIT-MPLNDWVGDFKRRI 4387
Query: 538 KQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVELG 717
Q + T + ++W GGL EAY TA RQ VAQ+NKW+LEEL L +
Sbjct: 4388 DQFDLLGKT------KDFQKGQVWFGGLLFPEAYLTATRQYVAQANKWSLEELELQMIPE 4441
Query: 718 EGKIDKNTCIVTGLRLMGSEIVDSKTLKL 804
+ ID+++ ++ G+ + G + DSKTL++
Sbjct: 4442 DQGIDEDSFVIEGVSMEGGHL-DSKTLQV 4469
>sp|P78716|DYHC_FUSSO Dynein heavy chain, cytosolic (DYHC)
Length = 4349
Score = 60.8 bits (146), Expect = 4e-09
Identities = 25/52 (48%), Positives = 42/52 (80%)
Frame = +1
Query: 1 WIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVD 156
WI++LP+ + P++LGLP +AEK+LL LG+SLIGN+ K+ + L++ E++V +
Sbjct: 4297 WIHRLPEREPPTYLGLPANAEKLLLGGLGRSLIGNLRKVTELLDEGEQLVTE 4348
>sp|P45443|DYHC_NEUCR Dynein heavy chain, cytosolic (DYHC)
Length = 4367
Score = 59.3 bits (142), Expect = 1e-08
Identities = 26/52 (50%), Positives = 39/52 (75%)
Frame = +1
Query: 1 WIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVD 156
WI KLP+ + P++LGLP +AEK+LL LG+SLIGN+ K+ L++ E I+ +
Sbjct: 4311 WIQKLPEREPPTYLGLPANAEKLLLVGLGKSLIGNLKKVTDLLDEGEAIMAE 4362
>sp|Q9NYC9|DYH9_HUMAN Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9)
Length = 4486
Score = 57.0 bits (136), Expect = 6e-08
Identities = 52/235 (22%), Positives = 102/235 (43%), Gaps = 5/235 (2%)
Frame = +1
Query: 25 QTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVDQRKSKRTIELGDSRPV 204
++P GL +AE LT + L +L++Q R S+ G +R
Sbjct: 4172 ESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQP------------RDSQARDGAGATREE 4219
Query: 205 WMRQLYQSTQTWLQ---LLPKVVIPLQRTTENIKDPIYRCFEREVNSGSNLLLIVRKDLE 375
++ L + + +P+++ ++ T I C + L +++ L
Sbjct: 4220 KVKALLEEILERVTDEFNIPELMAKVEERTPYIVVAFQECGRMNI-----LTREIQRSLR 4274
Query: 376 DISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIK--YPISSGLTVIQWIHDFADRVKQLI 549
++ G T+H ++ L ++P SW + YP ++GL W D +R+K+L
Sbjct: 4275 ELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAA--WFPDLLNRIKEL- 4331
Query: 550 HISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVEL 714
+G + S +WL G F +++ TAI Q+ A+ N+W L+++ L ++
Sbjct: 4332 -----EAWTGDFTMPST-VWLTGFFNPQSFLTAIMQSTARKNEWPLDQIALQCDM 4380
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,529,583
Number of Sequences: 369166
Number of extensions: 1824883
Number of successful extensions: 4971
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4803
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4956
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)