Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= Dr_sW_009_D09 (850 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 189 6e-48 sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 188 1e-47 sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (C... 177 4e-44 sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 176 1e-43 sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 175 1e-43 sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 174 2e-43 sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 174 3e-43 sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 174 3e-43 sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 172 1e-42 sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 172 1e-42
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor Length = 326 Score = 189 bits (481), Expect = 6e-48 Identities = 100/271 (36%), Positives = 148/271 (54%), Gaps = 6/271 (2%) Frame = +3 Query: 51 WEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDMNQIEF 230 W +K ++NK+Y+ D RRNIWE+N++ I++HNL+ DLG +++GLN+F+DM EF Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80 Query: 231 QSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITT------PNNIKLPDSWDWREKGAVSP 392 ++ L+ +SR I + NN +PD DWRE G V+ Sbjct: 81 KAKYLT------------------EMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTE 122 Query: 393 VGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAYA 572 V +Q N +AF+ G +EGQ +T S+QQ++DCS +GN+GC GG++ AY Sbjct: 123 VKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQ 182 Query: 573 YLADYGSELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAA 752 YL +G E + YP+ C+Y+K L K G+ V G E +L N V P + A Sbjct: 183 YLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVA 242 Query: 753 IDASPTSFKQYKTGIYDDTSCSSNNVNHAVL 845 +D + F Y++GIY +CS VNHAVL Sbjct: 243 VDVE-SDFMMYRSGIYQSQTCSPLRVNHAVL 272
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U) Length = 334 Score = 188 bits (478), Expect = 1e-47 Identities = 102/274 (37%), Positives = 148/274 (54%), Gaps = 1/274 (0%) Frame = +3 Query: 30 NSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFS 209 + L+ W +K + Y + RR +WE+NM+ I+ HN ++ GK F++ +N F Sbjct: 22 DQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFG 81 Query: 210 DMNQIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVS 389 DM EF+ + + P + LP S DWR+KG V+ Sbjct: 82 DMTNEEFRQMM--------------GCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVT 127 Query: 390 PVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAY 569 PV NQ+ +AF+A GALEGQ F T L LS+Q ++DCS GN GC GG +++A+ Sbjct: 128 PVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAF 187 Query: 570 AYLADYGS-ELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPIS 746 Y+ + G + +E YP+V + CKY + GF V+ GKE LM AV +GPIS Sbjct: 188 QYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPIS 247 Query: 747 AAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLV 848 A+DA +SF+ YK+GIY + CSS N++H VLV Sbjct: 248 VAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLV 281
>sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (Catlrp-p) Length = 333 Score = 177 bits (448), Expect = 4e-44 Identities = 110/277 (39%), Positives = 152/277 (54%), Gaps = 6/277 (2%) Frame = +3 Query: 36 QLNKDWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDM 215 +L+ +W+D+KT + K YS E + +RR +WEENM IK HN + LGK F++ +N+F D Sbjct: 24 KLDAEWKDWKTKYAKSYSPE-EALRRAVWEENMRMIKLHNKENSLGKNNFTMKMNKFGDQ 82 Query: 216 NQIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPN-----NIKLPDSWDWREKG 380 EF+ +I ++ +T P+ +I LPD DWRE+G Sbjct: 83 TSEEFRKSIDNIPIPAA-------------------MTDPHAQNHVSIGLPDYKDWREEG 123 Query: 381 AVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILS 560 V+PV NQ +AFAAAGA+EGQ F T L LS Q ++DCS GN GC G Sbjct: 124 YVTPVRNQGKCGSCWAFAAAGAIEGQMFWKTGNLTPLSVQNLLDCSKTVGNKGCQSGTAH 183 Query: 561 KAYAY-LADYGSELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIG 737 +A+ Y L + G E + YP+ + C+Y A+ + + E L AV +IG Sbjct: 184 QAFEYVLKNKGLEAEATYPYEGKDGPCRYRSENASANITDYVNLP-PNELYLWVAVASIG 242 Query: 738 PISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLV 848 P+SAAIDAS SF+ Y GIY + +CSS VNHAVLV Sbjct: 243 PVSAAIDASHDSFRFYNGGIYYEPNCSSYFVNHAVLV 279
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 333 Score = 176 bits (445), Expect = 1e-43 Identities = 100/271 (36%), Positives = 142/271 (52%), Gaps = 1/271 (0%) Frame = +3 Query: 39 LNKDWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDMN 218 L W +K + N+ Y + RR +WE+NM+ I+ HN ++ GK F++ +N F DM Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84 Query: 219 QIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVG 398 EF+ + + P + P S DWREKG V+PV Sbjct: 85 SEEFRQVMNGFQNRKPR--------------KGKVFQEPLFYEAPRSVDWREKGYVTPVK 130 Query: 399 NQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAYAYL 578 NQ +AF+A GALEGQ F T L LS+Q ++DCS GN GC GG++ A+ Y+ Sbjct: 131 NQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYV 190 Query: 579 ADYGS-ELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAAI 755 D G + +E YP+ +CKY+ + GF + + ++A LM AV +GPIS AI Sbjct: 191 QDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKA-LMKAVATVGPISVAI 249 Query: 756 DASPTSFKQYKTGIYDDTSCSSNNVNHAVLV 848 DA SF YK GIY + CSS +++H VLV Sbjct: 250 DAGHESFLFYKEGIYFEPDCSSEDMDHGVLV 280
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 333 Score = 175 bits (444), Expect = 1e-43 Identities = 100/275 (36%), Positives = 143/275 (52%), Gaps = 2/275 (0%) Frame = +3 Query: 30 NSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFS 209 + LN W +K + Y + RR +WE+NM+ I+ HN ++ GK F++ +N F Sbjct: 22 DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFG 81 Query: 210 DMNQIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVS 389 DM EF+ + + P ++P S DWREKG V+ Sbjct: 82 DMTNEEFRQVMNGFQNQKH--------------KKGKMFQEPLFAEIPKSVDWREKGYVT 127 Query: 390 PVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAY 569 PV NQ +AF+A GALEGQ F T L LS+Q ++DCS GN GC GG++ A+ Sbjct: 128 PVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAF 187 Query: 570 AYLADYGS-ELDEDYPFV-KCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPI 743 Y+ D G + +E YP++ + C Y + GF + + +E LM AV +GPI Sbjct: 188 RYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ-REKALMKAVATLGPI 246 Query: 744 SAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLV 848 S AIDA SF+ YK+GIY D CSS +++H VLV Sbjct: 247 SVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLV 281
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine proteinase) [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 334 Score = 174 bits (442), Expect = 2e-43 Identities = 97/268 (36%), Positives = 144/268 (53%), Gaps = 1/268 (0%) Frame = +3 Query: 48 DWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDMNQIE 227 +W +K+ + Y + RR IWE+NM I+ HN ++ G+ FS+ +N F DM E Sbjct: 28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEE 87 Query: 228 FQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQR 407 F+ + + P +K+P S DWREKG V+PV NQ Sbjct: 88 FRQVVNGYRHQKH--------------KKGRLFQEPLMLKIPKSVDWREKGCVTPVKNQG 133 Query: 408 NNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAYAYLADY 587 +AF+A+G LEGQ F T L LS+Q ++DCS GN GC GG++ A+ Y+ + Sbjct: 134 QCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKEN 193 Query: 588 GS-ELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAAIDAS 764 G + +E YP+ + +CKY A GF + + ++A LM AV +GPIS A+DAS Sbjct: 194 GGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEKA-LMKAVATVGPISVAMDAS 252 Query: 765 PTSFKQYKTGIYDDTSCSSNNVNHAVLV 848 S + Y +GIY + +CSS N++H VL+ Sbjct: 253 HPSLQFYSSGIYYEPNCSSKNLDHGVLL 280
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 341 Score = 174 bits (441), Expect = 3e-43 Identities = 93/270 (34%), Positives = 147/270 (54%), Gaps = 2/270 (0%) Frame = +3 Query: 45 KDWEDYKTIFNKKYSDETD-LIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDMNQ 221 ++W +K K Y DET+ R I+ EN I +HN +F GK F + +N+++D+ Sbjct: 27 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLH 86 Query: 222 IEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGN 401 EF+ + FI+ P ++ LP S DWR KGAV+ V + Sbjct: 87 HEFRQ----LMNGFNYTLHKQLRAADESFKGVTFIS-PAHVTLPKSVDWRTKGAVTAVKD 141 Query: 402 QRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAYAYLA 581 Q + +AF++ GALEGQ+F + L LS+Q ++DCS YGN+GC GG++ A+ Y+ Sbjct: 142 QGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIK 201 Query: 582 DYGS-ELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAAID 758 D G + ++ YP+ + +C ++K GF + +G E + AV +GP+S AID Sbjct: 202 DNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAID 261 Query: 759 ASPTSFKQYKTGIYDDTSCSSNNVNHAVLV 848 AS SF+ Y G+Y++ C + N++H VLV Sbjct: 262 ASHESFQFYSEGVYNEPQCDAQNLDHGVLV 291
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 334 Score = 174 bits (441), Expect = 3e-43 Identities = 103/283 (36%), Positives = 149/283 (52%), Gaps = 2/283 (0%) Frame = +3 Query: 6 ASRIDSNVNSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKF 185 A ++D N L+ DW +K + Y + RR +WE+NM+ I+ HN ++ GK F Sbjct: 18 APKLDQN----LDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGF 73 Query: 186 SVGLNEFSDMNQIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWD 365 S+ +N F DM EF+ + + +++P S D Sbjct: 74 SMAMNAFGDMTNEEFRQVMNGFQNQKH--------------KKGKVFHESLVLEVPKSVD 119 Query: 366 WREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCY 545 WREKG V+ V NQ +AF+A GALEGQ F T L LS+Q ++DCS GN GC Sbjct: 120 WREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCN 179 Query: 546 GGILSKAYAYLADYGS-ELDEDYPFVKCNSN-CKYDKSLATVKPYGFKYVSRGKEADLMN 719 GG++ A+ Y+ D G + +E YP++ +N C Y + GF + + +E LM Sbjct: 180 GGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIPQ-REKALMK 238 Query: 720 AVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLV 848 AV +GPIS AIDA +SF+ YK+GIY D CSS +++H VLV Sbjct: 239 AVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLV 281
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 339 Score = 172 bits (435), Expect = 1e-42 Identities = 93/272 (34%), Positives = 146/272 (53%), Gaps = 2/272 (0%) Frame = +3 Query: 39 LNKDWEDYKTIFNKKYSDETD-LIRRNIWEENMEFIKQHNLQFDLGKTKFSVGLNEFSDM 215 + ++W YK K Y++E + R I+ EN I +HN F GK + +GLN+++DM Sbjct: 24 IKEEWHTYKLQHRKNYANEVEERFRMKIFNENRHKIAKHNQLFAQGKVSYKLGLNKYADM 83 Query: 216 NQIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPV 395 EF+ + L +I P ++ +P S DWRE GAV+ V Sbjct: 84 LHHEFKETM-----NGYNHTLRQLMRERTGLVGATYI-PPAHVTVPKSVDWREHGAVTGV 137 Query: 396 GNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCYGGILSKAYAY 575 +Q + +AF++ GALEGQ+F L LS+Q ++DCS YGN+GC GG++ A+ Y Sbjct: 138 KDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRY 197 Query: 576 LADYGS-ELDEDYPFVKCNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAA 752 + D G + ++ YP+ + +C ++K+ GF + G E + AV +GP+S A Sbjct: 198 IKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVA 257 Query: 753 IDASPTSFKQYKTGIYDDTSCSSNNVNHAVLV 848 IDAS SF+ Y G+Y++ C N++H VLV Sbjct: 258 IDASHESFQLYSEGVYNEPECDEQNLDHGVLV 289
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 334 Score = 172 bits (435), Expect = 1e-42 Identities = 99/283 (34%), Positives = 146/283 (51%), Gaps = 2/283 (0%) Frame = +3 Query: 6 ASRIDSNVNSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENMEFIKQHNLQFDLGKTKF 185 A ++D N+++ W +K + Y + RR +WE+N + I HN ++ GK F Sbjct: 18 APKLDPNLDAH----WHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHAF 73 Query: 186 SVGLNEFSDMNQIEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWD 365 + +N F DM EF+ + + P + +P S D Sbjct: 74 RMAMNAFGDMTNEEFRQVMNGFQNQKH--------------KKGKLFHEPLLVDVPKSVD 119 Query: 366 WREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSVYYGNSGCY 545 W +KG V+PV NQ +AF+A GALEGQ F T L LS+Q ++DCS GN GC Sbjct: 120 WTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCN 179 Query: 546 GGILSKAYAYLADYGS-ELDEDYPFVKCNSN-CKYDKSLATVKPYGFKYVSRGKEADLMN 719 GG++ A+ Y+ D G + +E YP++ ++N C Y + GF + + +E LM Sbjct: 180 GGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQ-REKALMK 238 Query: 720 AVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLV 848 AV +GPIS AIDA TSF+ YK+GIY D CS +++H VLV Sbjct: 239 AVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLV 281
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 81,787,668 Number of Sequences: 369166 Number of extensions: 1464596 Number of successful extensions: 4625 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 4164 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 4338 length of database: 68,354,980 effective HSP length: 109 effective length of database: 48,218,865 effective search space used: 8341863645 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)