Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_D04
(480 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ERI6|RDH14_MOUSE Retinol dehydrogenase 14 (Alcohol deh... 57 3e-08
sp|Q9HBH5|RDH14_HUMAN Retinol dehydrogenase 14 (Alcohol deh... 57 3e-08
sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13 55 8e-08
sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 51 2e-06
sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 (Double subs... 47 2e-05
sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 44 2e-04
sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 (All-trans a... 35 0.068
sp|Q03326|OXIR_STRAT Probable oxidoreductase 34 0.15
sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family me... 33 0.44
sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase 32 0.98
>sp|Q9ERI6|RDH14_MOUSE Retinol dehydrogenase 14 (Alcohol dehydrogenase PAN2)
Length = 334
Score = 56.6 bits (135), Expect = 3e-08
Identities = 33/146 (22%), Positives = 72/146 (49%), Gaps = 2/146 (1%)
Frame = +3
Query: 3 ASESARVVYLVCPQYAKGNVKFDDINMDKNYDQDEAFNQSQLIRMLIMKYFVDNFSSSKL 182
+S +R+V + Y G + F+D+N +++Y++ +++S+L +L + + +
Sbjct: 179 SSAPSRIVVVSSKLYKYGEINFEDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNV 238
Query: 183 TFNACDPG--PTYSGFHDRSRYNSNFVSRNIFKVLNVLFLRGTWQATATPEMLCVSEELK 356
T N PG T G H + ++R +F +++ F + + T L S +++
Sbjct: 239 TVNVLHPGIVRTNLGRH----IHIPLLARPLFNLVSWAFFKTPLEGAQTSIYLACSPDVE 294
Query: 357 GKTGKLFRDLQELTIDNKALDRDLVK 434
G +G+ F D +E + KA+D + +
Sbjct: 295 GVSGRYFGDCKEEELLPKAMDESVAR 320
>sp|Q9HBH5|RDH14_HUMAN Retinol dehydrogenase 14 (Alcohol dehydrogenase PAN2)
Length = 336
Score = 56.6 bits (135), Expect = 3e-08
Identities = 34/146 (23%), Positives = 72/146 (49%), Gaps = 2/146 (1%)
Frame = +3
Query: 3 ASESARVVYLVCPQYAKGNVKFDDINMDKNYDQDEAFNQSQLIRMLIMKYFVDNFSSSKL 182
+S +R+V + Y G++ FDD+N +++Y++ +++S+L +L + + +
Sbjct: 181 SSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNV 240
Query: 183 TFNACDPG--PTYSGFHDRSRYNSNFVSRNIFKVLNVLFLRGTWQATATPEMLCVSEELK 356
T N PG T G H + + + +F +++ F + + T L S E++
Sbjct: 241 TVNVLHPGIVRTNLGRH----IHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVE 296
Query: 357 GKTGKLFRDLQELTIDNKALDRDLVK 434
G +G+ F D +E + KA+D + +
Sbjct: 297 GVSGRYFGDCKEEELLPKAMDESVAR 322
>sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13
Length = 334
Score = 55.1 bits (131), Expect = 8e-08
Identities = 47/162 (29%), Positives = 76/162 (46%), Gaps = 3/162 (1%)
Frame = +3
Query: 3 ASESARVVYLVCPQYAKGNVKFDDINMD-KNYDQDEAFNQSQLIRMLIMKYFVDNFSSSK 179
AS +R++ L + G++ F+D+N K YD A+ QS+L +L K S
Sbjct: 163 ASAPSRIINLSSLAHVAGHIDFEDLNWQMKKYDTKAAYCQSKLAVVLFTKELSHRLQGSG 222
Query: 180 LTFNACDPG--PTYSGFHDRSRYNSNFVSRNIFKVLNVLFLRGTWQATATPEMLCVSEEL 353
+T NA PG T G H +NS F + +LF + A L V+EEL
Sbjct: 223 VTVNALHPGVARTELGRH-TGMHNSAFSGFMLGPFFWLLF-KSPQLAAQPSTYLAVAEEL 280
Query: 354 KGKTGKLFRDLQELTIDNKALDRDLVKYVELLCKKWSKSSQL 479
+ +GK F L+E +A D ++ + + W++S++L
Sbjct: 281 ENVSGKYFDGLREKAPSPEAEDEEVAR------RLWTESARL 316
>sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13
Length = 331
Score = 50.8 bits (120), Expect = 2e-06
Identities = 39/160 (24%), Positives = 72/160 (45%), Gaps = 1/160 (0%)
Frame = +3
Query: 3 ASESARVVYLVCPQYAKGNVKFDDINMD-KNYDQDEAFNQSQLIRMLIMKYFVDNFSSSK 179
AS +R++ L + G++ FDD+N + Y+ A+ QS+L +L K S
Sbjct: 163 ASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSG 222
Query: 180 LTFNACDPGPTYSGFHDRSRYNSNFVSRNIFKVLNVLFLRGTWQATATPEMLCVSEELKG 359
+T NA PG + + + + S + L ++ A L V+EEL
Sbjct: 223 VTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELAD 282
Query: 360 KTGKLFRDLQELTIDNKALDRDLVKYVELLCKKWSKSSQL 479
+GK F L++ +A D ++ + + W++S++L
Sbjct: 283 VSGKYFDGLKQKAPAPEAEDEEVAR------RLWAESARL 316
>sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 (Double substrate-specificity short chain
dehydrogenase/reductase 2)
Length = 316
Score = 47.0 bits (110), Expect = 2e-05
Identities = 41/157 (26%), Positives = 70/157 (44%), Gaps = 5/157 (3%)
Frame = +3
Query: 6 SESARVVYLVCPQYAKGNVKFDDINMDKNYDQDEAFNQSQLIRMLIMKYFVDNFSSSKLT 185
S ARVV L + G ++F D+ DK Y+ A+ S+L +L + + +T
Sbjct: 165 SAPARVVNLSSVAHHLGKIRFHDLQGDKYYNLGFAYCHSKLANVLFTRELAKRLKGTGVT 224
Query: 186 FNACDPGPTYSGFHDRSRYNSNFVSRNIFKVLNVLFLRGTWQATATPEMLCVSEELKGKT 365
A PG S S F+ ++++ + FL+ TW+ T ++E L+ +
Sbjct: 225 TYAVHPGIVRSKLVRHS-----FLLCLLWRLFSP-FLKTTWEGAQTSLHCALAEGLEPLS 278
Query: 366 GKLFRDLQELTI-----DNKALDRDLVKYVELLCKKW 461
GK F D ++ + +NK +R ELL +W
Sbjct: 279 GKYFSDCKKTWVSPRARNNKTAERLWNVSCELLGIRW 315
>sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12
Length = 316
Score = 43.5 bits (101), Expect = 2e-04
Identities = 39/157 (24%), Positives = 67/157 (42%), Gaps = 5/157 (3%)
Frame = +3
Query: 6 SESARVVYLVCPQYAKGNVKFDDINMDKNYDQDEAFNQSQLIRMLIMKYFVDNFSSSKLT 185
S ARVV L + G ++F D+ K Y A+ S+L +L + + +T
Sbjct: 165 SAPARVVNLSSIAHLIGKIRFHDLQGQKRYCSAFAYGHSKLANLLFTRELAKRLQGTGVT 224
Query: 186 FNACDPGPTYSGFHDRSRYNSNFVSRNIFKVLNVLFLRGTWQATATPEMLCVSEELKGKT 365
A PG S R+ Y + R L F + T Q T ++E+L+ +
Sbjct: 225 AYAVHPGVVLSEI-TRNSYLLCLLWR-----LFSPFFKSTSQGAQTSLHCALAEDLEPLS 278
Query: 366 GKLFRDLQELTIDNKALDRDLVKYV-----ELLCKKW 461
GK F D + + + ++A ++ + + ELL +W
Sbjct: 279 GKYFSDCKRMWVSSRARNKKTAERLWNVSCELLGIQW 315
>sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 (All-trans and 9-cis retinol
dehydrogenase)
Length = 316
Score = 35.4 bits (80), Expect = 0.068
Identities = 37/157 (23%), Positives = 65/157 (41%), Gaps = 5/157 (3%)
Frame = +3
Query: 6 SESARVVYLVCPQYAKGNVKFDDINMDKNYDQDEAFNQSQLIRMLIMKYFVDNFSSSKLT 185
S ARVV + + G + F D+ +K Y + A+ S+L +L + + +T
Sbjct: 165 SAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVT 224
Query: 186 FNACDPGPTYSGFHDRSRYNSNFVSRNIFKVLNVLFLRGTWQATATPEMLCVSEELKGKT 365
A PG S + R++S + L F++ + T ++E L+ +
Sbjct: 225 TYAVHPGVVRS---ELVRHSSLLC---LLWRLFSPFVKTAREGAQTSLHCALAEGLEPLS 278
Query: 366 GKLFRDLQELTI-----DNKALDRDLVKYVELLCKKW 461
GK F D + + +NK +R ELL +W
Sbjct: 279 GKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGIRW 315
>sp|Q03326|OXIR_STRAT Probable oxidoreductase
Length = 298
Score = 34.3 bits (77), Expect = 0.15
Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 4/131 (3%)
Frame = +3
Query: 12 SARVVYLVCPQYAKGNVKFDDINMDKN-YDQDEAFNQSQLIRMLIMKYFVDNFSSSKLTF 188
SAR+V + + F+D + + YD A+ QS+ +L +++ +T
Sbjct: 131 SARIVVVSSGAHLDAPFDFEDAHFARRPYDPWVAYGQSKAADVLFT-VGARRWAADGITV 189
Query: 189 NACDPGPTYSGFH---DRSRYNSNFVSRNIFKVLNVLFLRGTWQATATPEMLCVSEELKG 359
NA +PG + D + V + V + + + Q AT +L S LKG
Sbjct: 190 NALNPGYILTRLQRHVDDETMRAFGVMDDQGNVKPLPYYKTPEQGAATSVLLAASPLLKG 249
Query: 360 KTGKLFRDLQE 392
TG+ F D QE
Sbjct: 250 VTGRYFEDNQE 260
>sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member on chromosome X precursor
(DHRSXY)
Length = 330
Score = 32.7 bits (73), Expect = 0.44
Identities = 39/160 (24%), Positives = 69/160 (43%), Gaps = 4/160 (2%)
Frame = +3
Query: 12 SARVVYLVCPQYAKGNVKFDDINMDKNYDQDEAFNQSQLIRMLIMKYFVDNF---SSSKL 182
SARVV + + + DD+ Y A+ QS+L +++ Y + S +
Sbjct: 175 SARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKL-ALVLFTYHLQRLLAAEGSHV 233
Query: 183 TFNACDPGPTYSGFHDRSRYNSNFVSRNIFKVLNVLFLRGTWQATATPEMLCVSEELKGK 362
T N DPG + + + + +R K+L L + + T V+ EL+G
Sbjct: 234 TANVVDPGVVNTDLYK----HVFWATRLAKKLLGWLLFKTPDEGAWTSIYAAVTPELEGV 289
Query: 363 TGKLFRDLQELTIDNKALDRDLVKYVELLCKK-WSKSSQL 479
G+ + +E K+L V Y + L ++ WSKS ++
Sbjct: 290 GGRYLYNEKE----TKSLH---VTYNQKLQQQLWSKSCEM 322
>sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase
Length = 414
Score = 31.6 bits (70), Expect = 0.98
Identities = 28/96 (29%), Positives = 40/96 (41%), Gaps = 4/96 (4%)
Frame = +3
Query: 108 AFNQSQLIRMLIMKYFVDNFSSSKLTFNACDPG-PTYSGFHDRSRYNSNFVSRNIFKVLN 284
A+N+S+L +L S +T NA PG YS H S ++K+L
Sbjct: 292 AYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSAIHRNSW---------VYKLLF 342
Query: 285 VL---FLRGTWQATATPEMLCVSEELKGKTGKLFRD 383
L F + Q AT V+ EL+G G F +
Sbjct: 343 TLARPFTKSMQQGAATTVYCAVAPELEGLGGMYFNN 378
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,021,352
Number of Sequences: 369166
Number of extensions: 962160
Number of successful extensions: 2552
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2520
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2551
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 2822184570
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)