Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_C22
(880 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9DGM7|MVP_ICTPU Major vault protein (MVP) 414 e-115
sp|P34118|MVPA_DICDI Major vault protein alpha (MVP-alpha) 402 e-112
sp|Q90405|MVP_DISOM Major vault protein (MVP100) (P100) 402 e-112
sp|Q14764|MVP_HUMAN Major vault protein (MVP) (Lung resista... 394 e-109
sp|Q62667|MVP_RAT Major vault protein (MVP) 388 e-107
sp|Q9EQK5|MVP_MOUSE Major vault protein (MVP) 386 e-107
sp|P54659|MVPB_DICDI Major vault protein beta (MVP-beta) 335 1e-91
sp|P19934|TOLA_ECOLI Protein tolA 53 1e-06
sp|Q9UL16|CCDCJ_HUMAN Coiled-coil domain-containing protein... 41 0.004
sp|Q8XZV6|IF2_RALSO Translation initiation factor IF-2 41 0.005
>sp|Q9DGM7|MVP_ICTPU Major vault protein (MVP)
Length = 871
Score = 414 bits (1064), Expect = e-115
Identities = 209/293 (71%), Positives = 244/293 (83%)
Frame = +2
Query: 2 HNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLLLGPDFC 181
HNAAVQ+YDY+EK AR+ +GPDLVMLGPDE FT LSLSG KPK+ N+IK++CLLLGPDFC
Sbjct: 489 HNAAVQVYDYREKKARVVFGPDLVMLGPDEQFTVLSLSGEKPKRANVIKAICLLLGPDFC 548
Query: 182 TDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALASRIRGTV 361
TDII +ET+DHARL LQ++YNWHF+ + LFSVPDFVGDACKA+ASRIRG V
Sbjct: 549 TDIITIETADHARLQLQLAYNWHFEVKNHSDPAQAAALFSVPDFVGDACKAIASRIRGAV 608
Query: 362 AAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEPVDQRTRES 541
A+V+FDDFHKNS RII S+VFG D VR F QN L I+S+DIQSVEPVDQRTR++
Sbjct: 609 ASVQFDDFHKNSIRIICSAVFGFDEKLAVRSSLRFNQNGLVISSVDIQSVEPVDQRTRDA 668
Query: 542 LQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELLQLRAAS 721
LQKSVQLAIEITT SQEA+ARHEA+R+EQ+A+G+LERQ ITDQAEAER R ELL+L A S
Sbjct: 669 LQKSVQLAIEITTNSQEATARHEAERLEQEARGKLERQKITDQAEAERARKELLELEALS 728
Query: 722 AAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENELARVIAAR 880
AAVESTG AKAEAQSRAEA+RI+GEA V++AKLK EA IEAE E+ R+ AR
Sbjct: 729 AAVESTGAAKAEAQSRAEAARIQGEAAVQEAKLKVEALRIEAEAEMVRLAKAR 781
>sp|P34118|MVPA_DICDI Major vault protein alpha (MVP-alpha)
Length = 843
Score = 402 bits (1034), Expect = e-112
Identities = 202/293 (68%), Positives = 247/293 (84%)
Frame = +2
Query: 2 HNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLLLGPDFC 181
HN+AVQIYDYKEK +R+ +GPDLVMLGPDEHFT LSLSG KPK+P+ IK++ L LGPDF
Sbjct: 449 HNSAVQIYDYKEKKSRVVFGPDLVMLGPDEHFTVLSLSGDKPKRPHQIKAIALFLGPDFM 508
Query: 182 TDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALASRIRGTV 361
TD+++VETSDHARLSL++SYNW FK + K ++ K+F VPDFVGD+CKA+ASR+RG V
Sbjct: 509 TDVVIVETSDHARLSLKLSYNWEFKVDRSKIEDA-QKIFQVPDFVGDSCKAIASRVRGAV 567
Query: 362 AAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEPVDQRTRES 541
AAV FDDFHK SA +IR SVFG+D + +VR+ F F NNL IT+IDIQSVEPVDQRTR+S
Sbjct: 568 AAVSFDDFHKRSAEVIRQSVFGLDESGEVRKNFSFNSNNLVITNIDIQSVEPVDQRTRDS 627
Query: 542 LQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELLQLRAAS 721
LQKSVQLAIEITTKSQEA+ARHEA+R+EQ A+GRLERQ I D+A+AE R +LLQL+A S
Sbjct: 628 LQKSVQLAIEITTKSQEAAARHEAERLEQGARGRLERQKIHDEAQAELARKDLLQLQAQS 687
Query: 722 AAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENELARVIAAR 880
AAVESTGQA AEAQ+ AEA+ I EANV+QA+LKA+AT I +E+E++ + A R
Sbjct: 688 AAVESTGQATAEAQATAEAANIAAEANVKQAELKAQATKIRSESEISLLKAKR 740
>sp|Q90405|MVP_DISOM Major vault protein (MVP100) (P100)
Length = 852
Score = 402 bits (1032), Expect = e-112
Identities = 200/293 (68%), Positives = 244/293 (83%)
Frame = +2
Query: 2 HNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLLLGPDFC 181
HNAAVQ+YDY +K+AR+ +GP+LVML DE T LSLSGG+PK+P +I+SLCLLLGPDF
Sbjct: 464 HNAAVQVYDYSQKSARVVFGPELVMLETDEQLTVLSLSGGRPKRPGVIRSLCLLLGPDFF 523
Query: 182 TDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALASRIRGTV 361
TD+IV+ET+DHARL LQ++YNWHF+ + K+FSV DFVGDACKA+ASRIRG V
Sbjct: 524 TDVIVIETADHARLQLQLAYNWHFEVKDRSDPMESAKVFSVLDFVGDACKAIASRIRGAV 583
Query: 362 AAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEPVDQRTRES 541
A+V+FDDFHKNS+RI+R++VFG+D +VRE +FPQN+LC+TS+D+ SVEPVDQRTR++
Sbjct: 584 ASVQFDDFHKNSSRILRAAVFGLDPELRVRERLLFPQNSLCVTSVDVHSVEPVDQRTRDA 643
Query: 542 LQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELLQLRAAS 721
LQ+SVQLAIEITTKSQEA+AR EA R+EQ+AKGRLERQ I DQAE+ER R ELL L A S
Sbjct: 644 LQRSVQLAIEITTKSQEAAARQEAARLEQEAKGRLERQRILDQAESERARRELLLLEADS 703
Query: 722 AAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENELARVIAAR 880
AVES G A+AEA+SRAEASRIEGE +V QAKLKA+A IE E EL R+ AR
Sbjct: 704 TAVESRGAARAEAESRAEASRIEGEGSVLQAKLKAQALDIETEAELERLTKAR 756
>sp|Q14764|MVP_HUMAN Major vault protein (MVP) (Lung resistance-related protein)
Length = 893
Score = 394 bits (1011), Expect = e-109
Identities = 197/303 (65%), Positives = 243/303 (80%), Gaps = 10/303 (3%)
Frame = +2
Query: 2 HNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLLLGPDFC 181
HNAAVQ+YDY+EK AR+ +GP+LV LGP+E FT LSLS G+PK+P+ ++LCLLLGPDF
Sbjct: 464 HNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFF 523
Query: 182 TDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALASRIRGTV 361
TD+I +ET+DHARL LQ++YNWHF+ K KLFSVPDFVGDACKA+ASR+RG V
Sbjct: 524 TDVITIETADHARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAV 583
Query: 362 AAVRFDDFHKNSARIIRSSVFGVDANN----------KVREEFVFPQNNLCITSIDIQSV 511
A+V FDDFHKNSARIIR++VFG + + + R++ VFPQN L ++S+D+QSV
Sbjct: 584 ASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSV 643
Query: 512 EPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTR 691
EPVDQRTR++LQ+SVQLAIEITT SQEA+A+HEA R+EQ+A+GRLERQ I DQ+EAE+ R
Sbjct: 644 EPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKAR 703
Query: 692 TELLQLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENELARVI 871
ELL+L A S AVESTG AKAEA+SRAEA+RIEGE +V QAKLKA+A IE E EL RV
Sbjct: 704 KELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQ 763
Query: 872 AAR 880
R
Sbjct: 764 KVR 766
>sp|Q62667|MVP_RAT Major vault protein (MVP)
Length = 861
Score = 388 bits (996), Expect = e-107
Identities = 195/303 (64%), Positives = 240/303 (79%), Gaps = 10/303 (3%)
Frame = +2
Query: 2 HNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLLLGPDFC 181
HNAAVQ+YDY+ K AR+ +GP+LV L P+E FT LSLS G+PK+P+ ++LCLLLGPDF
Sbjct: 464 HNAAVQVYDYRAKRARVVFGPELVTLDPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFF 523
Query: 182 TDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALASRIRGTV 361
TD+I +ET+DHARL LQ++YNWHF+ + KLFSVPDFVGDACKA+ASR+RG V
Sbjct: 524 TDVITIETADHARLQLQLAYNWHFELKNRNDPAEAAKLFSVPDFVGDACKAIASRVRGAV 583
Query: 362 AAVRFDDFHKNSARIIRSSVFGVDANN----------KVREEFVFPQNNLCITSIDIQSV 511
A+V FDDFHKNSARIIR +VFG + + K R++ VFPQN L ++S+D+QSV
Sbjct: 584 ASVTFDDFHKNSARIIRMAVFGFEMSEDTGPDGTLLPKARDQAVFPQNGLVVSSVDVQSV 643
Query: 512 EPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTR 691
EPVDQRTR++LQ+SVQLAIEITT SQEA+A+HEA R+EQ+A+GRLERQ I DQ+EAE+ R
Sbjct: 644 EPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKAR 703
Query: 692 TELLQLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENELARVI 871
ELL+L A S AVESTG AKAEA+SRAEA+RIEGE +V QAKLKA+A IE E EL RV
Sbjct: 704 KELLELEAMSMAVESTGNAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELERVK 763
Query: 872 AAR 880
R
Sbjct: 764 KVR 766
>sp|Q9EQK5|MVP_MOUSE Major vault protein (MVP)
Length = 861
Score = 386 bits (991), Expect = e-107
Identities = 194/303 (64%), Positives = 239/303 (78%), Gaps = 10/303 (3%)
Frame = +2
Query: 2 HNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLLLGPDFC 181
HNAAVQ+YDY+ K AR+ +GP+LV L P+E FT LSLS G+PK+P+ ++LCLLLGPDF
Sbjct: 464 HNAAVQVYDYRAKRARVVFGPELVSLDPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFF 523
Query: 182 TDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALASRIRGTV 361
TD+I +ET+DHARL LQ++YNWHF+ + KLFSVPDFVGDACKA+ASR+RG V
Sbjct: 524 TDVITIETADHARLQLQLAYNWHFELKNRNDPEETAKLFSVPDFVGDACKAIASRVRGAV 583
Query: 362 AAVRFDDFHKNSARIIRSSVFGVDANN----------KVREEFVFPQNNLCITSIDIQSV 511
A+V FDDFHKNSARIIR +VFG + + + R+ VFPQN L ++S+D+QSV
Sbjct: 584 ASVTFDDFHKNSARIIRMAVFGFEMSEDAGPDGALLPRARDRAVFPQNGLVVSSVDVQSV 643
Query: 512 EPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTR 691
EPVDQRTR++LQ+SVQLAIEITT SQEA+A+HEA R+EQ+A+GRLERQ I DQ+EAE+ R
Sbjct: 644 EPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKAR 703
Query: 692 TELLQLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENELARVI 871
ELL+L A S AVESTG AKAEA+SRAEA+RIEGE +V QAKLKA+A IE E EL RV
Sbjct: 704 KELLELEAMSMAVESTGNAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELERVK 763
Query: 872 AAR 880
R
Sbjct: 764 KVR 766
>sp|P54659|MVPB_DICDI Major vault protein beta (MVP-beta)
Length = 846
Score = 335 bits (858), Expect = 1e-91
Identities = 176/291 (60%), Positives = 223/291 (76%)
Frame = +2
Query: 2 HNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLLLGPDFC 181
HNAAVQI+DY++K AR+ +GP+LVML PDE FT LSLSG PK+PN I+SL L LGPDF
Sbjct: 465 HNAAVQIFDYRKKEARVVFGPELVMLEPDEEFTVLSLSGKIPKRPNHIRSLALFLGPDFM 524
Query: 182 TDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALASRIRGTV 361
TD+I VET+DHARLSL++SYNWHFK E Q+ +KLF+ DF GD CKA S +R V
Sbjct: 525 TDLITVETADHARLSLKLSYNWHFKVE----QDNPSKLFATSDFTGDLCKATGSLVRAAV 580
Query: 362 AAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEPVDQRTRES 541
AA FD+FHK+S+ II+ +VFG + + F N L IT+ID+QSVEPVDQRT +S
Sbjct: 581 AASTFDNFHKHSSDIIQQAVFG-STDGSSNDCLYFETNGLVITNIDVQSVEPVDQRTLDS 639
Query: 542 LQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELLQLRAAS 721
LQKSVQLAIEITTKSQEA+AR EA+R+EQ A+G LERQ I D+A+ E +R++L+QL+A S
Sbjct: 640 LQKSVQLAIEITTKSQEATARQEAERLEQMARGELERQKIIDEAKNEESRSKLVQLQAQS 699
Query: 722 AAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENELARVIA 874
AAVESTGQA AEA++RAEA+ IE E+ ++QA+L A IEA +E+ + A
Sbjct: 700 AAVESTGQAVAEARARAEAAIIEAESEIKQARLSTRAIEIEALSEIENLKA 750
>sp|P19934|TOLA_ECOLI Protein tolA
Length = 421
Score = 52.8 bits (125), Expect = 1e-06
Identities = 40/119 (33%), Positives = 59/119 (49%)
Frame = +2
Query: 500 IQSVEPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEA 679
+QS E +R+ E + Q A E + Q A E +R++Q K RL Q QAE
Sbjct: 67 MQSQESSAKRSDEQRKMKEQQAAEELREKQAA----EQERLKQLEKERLAAQEQKKQAEE 122
Query: 680 ERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENE 856
+ EL Q +A AA ++ AKA+A++ A+A+ + AK KAEA +A E
Sbjct: 123 AAKQAELKQKQAEEAAAKAAADAKAKAEADAKAAEEAAKKAAADAKKKAEAEAAKAAAE 181
Score = 32.3 bits (72), Expect = 1.8
Identities = 28/98 (28%), Positives = 42/98 (42%)
Frame = +2
Query: 536 ESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELLQLRA 715
E QK + A +A A +A E+ AK +AEA + E Q +A
Sbjct: 128 ELKQKQAEEAAAKAAADAKAKAEADAKAAEEAAKKAAADAKKKAEAEAAKAAAE-AQKKA 186
Query: 716 ASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAE 829
+AA +A+A + AEA + E+AK +AE
Sbjct: 187 EAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAE 224
>sp|Q9UL16|CCDCJ_HUMAN Coiled-coil domain-containing protein 19 (Nasopharyngeal
epithelium-specific protein 1)
Length = 386
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/105 (25%), Positives = 50/105 (47%), Gaps = 1/105 (0%)
Frame = +2
Query: 518 VDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTR-T 694
+DQ QKS+Q E+ K +E R +EQ K + ER ++ +Q E E+ +
Sbjct: 90 LDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQML 149
Query: 695 ELLQLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAE 829
E ++ + + + + + +AE RI E ++A+L A+
Sbjct: 150 EYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQ 194
>sp|Q8XZV6|IF2_RALSO Translation initiation factor IF-2
Length = 964
Score = 40.8 bits (94), Expect = 0.005
Identities = 35/133 (26%), Positives = 56/133 (42%), Gaps = 6/133 (4%)
Frame = +2
Query: 494 IDIQSVEPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQA 673
+D++ V ++ R + + E+ + QEA R EA+R +Q E++ + A
Sbjct: 121 VDVEEVARREEEQRRQAELLARQEAELKAR-QEAMEREEAERRARQEAAEAEQRRQAELA 179
Query: 674 EAERTRTELLQLRAASAAVESTGQAKAE------AQSRAEASRIEGEANVEQAKLKAEAT 835
A++ E RAA+ A + + KAE A R A + EA K+KAE
Sbjct: 180 -AKKAEEEAAAARAAAEASDEAPRRKAEEDAARLASEREAAQKAAEEARAAADKIKAEED 238
Query: 836 TIEAENELARVIA 874
E A A
Sbjct: 239 GARKRREAAEAEA 251
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,147,153
Number of Sequences: 369166
Number of extensions: 1596291
Number of successful extensions: 5397
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5167
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5350
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8742211660
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)