Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_B16
(897 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O95425|SVIL_HUMAN Supervillin (Archvillin) (p205/p250) 140 5e-33
sp|Q8K4L3|SVIL_MOUSE Supervillin (Archvillin) (p205/p250) 138 2e-32
sp|Q28046|ADSV_BOVIN Adseverin (Scinderin) (SC) 70 1e-11
sp|Q9Y6U3|ADSV_HUMAN Adseverin (Scinderin) 69 2e-11
sp|Q60604|ADSV_MOUSE Adseverin (Scinderin) (Gelsolin-like p... 68 4e-11
sp|Q62468|VILI_MOUSE Villin-1 67 5e-11
sp|Q07171|GELS_DROME Gelsolin precursor 66 1e-10
sp|O88398|AVIL_MOUSE Advillin (p92) (Actin-binding protein ... 64 4e-10
sp|Q27319|GELS_HOMAM Gelsolin, cytoplasmic (Actin-depolymer... 64 7e-10
sp|P09327|VILI_HUMAN Villin-1 63 1e-09
>sp|O95425|SVIL_HUMAN Supervillin (Archvillin) (p205/p250)
Length = 2214
Score = 140 bits (353), Expect = 5e-33
Identities = 82/250 (32%), Positives = 137/250 (54%), Gaps = 8/250 (3%)
Frame = +3
Query: 3 QGISTSITEKTASALLTIDLDKDRTTQIRVKQHHESPAFCRLFGGTMVVHIG-KQQFSEN 179
QG ++++EK SAL+T++LD++R Q++V Q E P F + F G MVVH G +++ EN
Sbjct: 1817 QGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEEN 1876
Query: 180 V-SKSRLFVIRGEIESEAHFVEVLCESQSLRERGVFLLLNIKRSKCYLWLGNCASAESRS 356
V S+ RL+ +RGE+ E + +EV C SLR R ++LN+ ++ YLW G A A ++
Sbjct: 1877 VQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKE 1936
Query: 357 SAFFCIKQLLAKKPIDLRI-TLNDIKIEEIEQGKEPRTFWEDMGIIKKWKSSYIYHD--- 524
++ + P++ + + + + I E ++G EP FW+ +G + + D
Sbjct: 1937 VGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGS 1996
Query: 525 --LVPIRGWFVSGLTGVFILNEMNYSLCPDGENNIVPAFPLLQATLYKSSQPTLFLIWTP 698
P R + +S +G F E Y P ++V + P LQ LY + QP LFL+
Sbjct: 1997 FNFAP-RLFILSSSSGDFAATEFVY---PARAPSVVSSMPFLQEDLYSAPQPALFLVDNH 2052
Query: 699 VHIFIWEGWW 728
+++W+GWW
Sbjct: 2053 HEVYLWQGWW 2062
Score = 30.0 bits (66), Expect = 9.1
Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 5/102 (4%)
Frame = +3
Query: 195 LFVIRGEIESEAHFVEVLCESQSLRERGVFLLLNIKRSKCYLWLGNCASAESRSSAFFCI 374
L I+G + VE + +L FLLL+ C+LW+G A+ ++ A
Sbjct: 1445 LLQIKGRRHVQTRLVEP--RASALNSGDCFLLLS--PHCCFLWVGEFANVIEKAKASELA 1500
Query: 375 KQLLAKKPIDLRITLNDIKIEEIEQGKEPRT-----FWEDMG 485
+ K+ + R T I+ IE+G T FW+ +G
Sbjct: 1501 TLIQTKRELGCRATY----IQTIEEGINTHTHAAKDFWKLLG 1538
>sp|Q8K4L3|SVIL_MOUSE Supervillin (Archvillin) (p205/p250)
Length = 2170
Score = 138 bits (348), Expect = 2e-32
Identities = 82/250 (32%), Positives = 136/250 (54%), Gaps = 8/250 (3%)
Frame = +3
Query: 3 QGISTSITEKTASALLTIDLDKDRTTQIRVKQHHESPAFCRLFGGTMVVHIG-KQQFSEN 179
QG ++++EK SAL+T++LD++R Q++V Q E P F + F G MVVH G +++ EN
Sbjct: 1773 QGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEEN 1832
Query: 180 V-SKSRLFVIRGEIESEAHFVEVLCESQSLRERGVFLLLNIKRSKCYLWLGNCASAESRS 356
V S+ RL+ +RGE+ E + +EV C SLR R ++LNI ++ YLW G A ++
Sbjct: 1833 VQSEWRLYCVRGEVPMEGNLLEVACHCSSLRSRTSMVVLNINKALIYLWHGCKAQGHTKE 1892
Query: 357 SAFFCIKQLLAKKPIDLRI-TLNDIKIEEIEQGKEPRTFWEDMGIIKKWKSSYIYHD--- 524
++ + P++ + + +++ I E ++G EP FW+ +G + + D
Sbjct: 1893 VGRTAANKIKEECPLEAGLHSSSNVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGS 1952
Query: 525 --LVPIRGWFVSGLTGVFILNEMNYSLCPDGENNIVPAFPLLQATLYKSSQPTLFLIWTP 698
P R + +S +G F E Y P + V + P LQ LY + QP LFL+
Sbjct: 1953 FNFAP-RLFILSSSSGDFSATEFVY---PAQAPSAVSSMPFLQEDLYSAPQPALFLVDNH 2008
Query: 699 VHIFIWEGWW 728
+++W+GWW
Sbjct: 2009 HEVYLWQGWW 2018
Score = 31.6 bits (70), Expect = 3.1
Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 5/105 (4%)
Frame = +3
Query: 186 KSRLFVIRGEIESEAHFVEVLCESQSLRERGVFLLLNIKRSKCYLWLGNCASAESRSSAF 365
K L I+G + VE + SL FLLL+ + C+LW+G ++ ++ A
Sbjct: 1398 KLMLLQIKGRRHVQTRLVEP--RASSLNSGDCFLLLSPQY--CFLWVGEFSNVIEKAKAS 1453
Query: 366 FCIKQLLAKKPIDLRITLNDIKIEEIEQGKEPRT-----FWEDMG 485
+ K+ + R T I+ IE+G T FW+ +G
Sbjct: 1454 ELATLIQTKRELGCRATY----IQTIEEGINTHTHAAKDFWKLLG 1494
>sp|Q28046|ADSV_BOVIN Adseverin (Scinderin) (SC)
Length = 715
Score = 69.7 bits (169), Expect = 1e-11
Identities = 56/205 (27%), Positives = 90/205 (43%), Gaps = 10/205 (4%)
Frame = +3
Query: 3 QGISTSITEKTASALLTIDLDKD---RTTQIRVKQHHESPAFCRLFGGTMVV----HIGK 161
QG + + E T SA LT+ LD+ + QIRV Q E LF ++ K
Sbjct: 441 QGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPAHLLSLFKDKPLIIYKNGTSK 500
Query: 162 QQFSENVSKSRLFVIRGEIESEAHFVEVLCESQSLRERGVFLLLNIKRSKCYLWLGNCAS 341
++ RLF +R + S +EV ++ SL VF+L ++++ Y+W+G ++
Sbjct: 501 KEGQAPAPPIRLFQVRRNLASITRIMEVDVDANSLNSNDVFVL-KLRQNNGYIWIGKGST 559
Query: 342 AESRSSAFFCIKQLLAKKPIDLRITLNDIKIEEIEQGKEPRTFWEDMGIIKKWKSSYIYH 521
E A + L K I++GKEP FW +G K +++S +
Sbjct: 560 QEEEKGAEYVASVLKCKT-------------STIQEGKEPEEFWNSLGGKKDYQTSPLLE 606
Query: 522 DLV---PIRGWFVSGLTGVFILNEM 587
P R + S TG FI+ E+
Sbjct: 607 SQAEDHPPRLYGCSNKTGRFIIEEV 631
>sp|Q9Y6U3|ADSV_HUMAN Adseverin (Scinderin)
Length = 715
Score = 68.6 bits (166), Expect = 2e-11
Identities = 59/205 (28%), Positives = 91/205 (44%), Gaps = 10/205 (4%)
Frame = +3
Query: 3 QGISTSITEKTASALLTIDLDKD---RTTQIRVKQHHESPAFCRLFGGTMVV----HIGK 161
QG + + E T SA LT+ LD+ + QIRV Q E LF ++ K
Sbjct: 441 QGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSK 500
Query: 162 QQFSENVSKSRLFVIRGEIESEAHFVEVLCESQSLRERGVFLLLNIKRSKCYLWLGNCAS 341
+ +RLF +R + S VEV ++ SL VF+L + ++ Y+W+G AS
Sbjct: 501 KGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVL-KLPQNSGYIWVGKGAS 559
Query: 342 AESRSSAFFCIKQLLAKKPIDLRITLNDIKIEEIEQGKEPRTFWEDMGIIKKWKSSYIYH 521
E A + L K TL I++G+EP FW +G K +++S +
Sbjct: 560 QEEEKGAEYVASVLKCK-------TLR------IQEGEEPEEFWNSLGGKKDYQTSPLLE 606
Query: 522 DLV---PIRGWFVSGLTGVFILNEM 587
P R + S TG F++ E+
Sbjct: 607 TQAEDHPPRLYGCSNKTGRFVIEEI 631
>sp|Q60604|ADSV_MOUSE Adseverin (Scinderin) (Gelsolin-like protein)
Length = 715
Score = 67.8 bits (164), Expect = 4e-11
Identities = 56/205 (27%), Positives = 88/205 (42%), Gaps = 10/205 (4%)
Frame = +3
Query: 3 QGISTSITEKTASALLTIDLDKD---RTTQIRVKQHHESPAFCRLFGGTMVV----HIGK 161
QG + + E T SA LT+ LD+ + Q+RV Q E LF ++ K
Sbjct: 441 QGANATRDELTMSAFLTVQLDRSLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKNGTSK 500
Query: 162 QQFSENVSKSRLFVIRGEIESEAHFVEVLCESQSLRERGVFLLLNIKRSKCYLWLGNCAS 341
++ +RLF +R + S VEV ++ SL F+L + R+ ++W+G AS
Sbjct: 501 KEGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDTFVL-KLPRNNGFIWIGKGAS 559
Query: 342 AESRSSAFFCIKQLLAKKPIDLRITLNDIKIEEIEQGKEPRTFWEDMGIIKKWKSSYIYH 521
E A + L K I++GKEP FW +G +++S +
Sbjct: 560 QEEEKGAEYVADVLKCKA-------------SRIQEGKEPEEFWNSLGGRGDYQTSPLLE 606
Query: 522 DLV---PIRGWFVSGLTGVFILNEM 587
P R + S TG FI+ E+
Sbjct: 607 TRAEDHPPRLYGCSNKTGRFIIEEV 631
>sp|Q62468|VILI_MOUSE Villin-1
Length = 827
Score = 67.4 bits (163), Expect = 5e-11
Identities = 54/167 (32%), Positives = 74/167 (44%), Gaps = 6/167 (3%)
Frame = +3
Query: 3 QGISTSITEKTASALLTIDLDK---DRTTQIRVKQHHESPAFCRLFGGTMVVHIG---KQ 164
QG S E ASA + LD+ D QIRV E P +F G MVV+ G ++
Sbjct: 447 QGSQASQDEIAASAYQAVLLDQKYNDEPVQIRVTMGKEPPHLMSIFKGRMVVYQGGTSRK 506
Query: 165 QFSENVSKSRLFVIRGEIESEAHFVEVLCESQSLRERGVFLLLNIKRSKCYLWLGNCASA 344
E V +RLF +RG EV + SL VF+L S CYLW G S
Sbjct: 507 NNLEPVPSTRLFQVRGTNADNTKAFEVTARATSLNSNDVFILKT--PSCCYLWCGKGCSG 564
Query: 345 ESRSSAFFCIKQLLAKKPIDLRITLNDIKIEEIEQGKEPRTFWEDMG 485
+ R +AK D T++ + + + +G+EP FW +G
Sbjct: 565 DERE---------MAKMVAD---TISRTEKQVVVEGQEPANFWMALG 599
>sp|Q07171|GELS_DROME Gelsolin precursor
Length = 798
Score = 66.2 bits (160), Expect = 1e-10
Identities = 40/133 (30%), Positives = 66/133 (49%)
Frame = +3
Query: 84 IRVKQHHESPAFCRLFGGTMVVHIGKQQFSENVSKSRLFVIRGEIESEAHFVEVLCESQS 263
++ Q HE F ++F G ++ F+ ++LF IRG +ES+ H EV +S S
Sbjct: 540 VQTNQGHEPRHFYKIFKGKLLT-----SFTALPVTAQLFRIRGTVESDVHASEVAADSSS 594
Query: 264 LRERGVFLLLNIKRSKCYLWLGNCASAESRSSAFFCIKQLLAKKPIDLRITLNDIKIEEI 443
L F+L + K K Y+W G ASA + +A +D+++E++
Sbjct: 595 LASSDAFVLHSGKSHKIYIWNGLGASAFEKQAAVDRFSDY-----------WDDVELEQV 643
Query: 444 EQGKEPRTFWEDM 482
E+G EP FWE++
Sbjct: 644 EEGAEPDEFWEEL 656
Score = 30.8 bits (68), Expect = 5.4
Identities = 21/77 (27%), Positives = 31/77 (40%), Gaps = 6/77 (7%)
Frame = +3
Query: 315 YLWLGNCASAESRSSAFFCIKQLLAKKPIDLRITLNDIKIEEIEQGKEPRTF------WE 476
YLW+G S E K +P + + + I + QGKEPR F W+
Sbjct: 717 YLWVGYGVSEEENGKLLDTAKLYFNLEPTAR--SFDTVSIIRVPQGKEPRVFKRMFPNWD 774
Query: 477 DMGIIKKWKSSYIYHDL 527
D W++ Y D+
Sbjct: 775 D----NYWQNQPSYEDM 787
>sp|O88398|AVIL_MOUSE Advillin (p92) (Actin-binding protein DOC6)
Length = 819
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/208 (29%), Positives = 95/208 (45%), Gaps = 13/208 (6%)
Frame = +3
Query: 3 QGISTSITEKTASALLTIDLDK--DRT-TQIRVKQHHESPAFCRLFGGTMVVHIGKQQFS 173
QG S E ASA +++D+ DR Q+RV E F +F G +V++ G
Sbjct: 444 QGRHASRDELAASAYRAVEVDQQFDRAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRK 503
Query: 174 ENVSKS---RLFVIRGEIESEAHFVEVLCESQSLRERGVFLLLNIKRSKCYLWLGNCASA 344
N RLF I G +S VEV + SL VFLL +++ YLW G +S
Sbjct: 504 GNEEPDPPVRLFQIHGNDKSNTKAVEVSASASSLISNDVFLLRT--QAEHYLWYGKGSSG 561
Query: 345 ESRSSAFFCIKQLLAKKPIDLRITLNDIKIEEIEQGKEPRTFWEDMGIIKKWKSSYIYHD 524
+ R+ +AK+ +DL L D + + +G+EP FW+ +G K++Y
Sbjct: 562 DERA---------MAKELVDL---LCDGNADTVAEGQEPPEFWDLLG----GKTAYANDK 605
Query: 525 L-------VPIRGWFVSGLTGVFILNEM 587
V +R + S TG F++ E+
Sbjct: 606 RLQQETLDVQVRLFECSNKTGRFLVTEV 633
>sp|Q27319|GELS_HOMAM Gelsolin, cytoplasmic (Actin-depolymerizing factor) (ADF)
Length = 754
Score = 63.5 bits (153), Expect = 7e-10
Identities = 49/173 (28%), Positives = 83/173 (47%), Gaps = 12/173 (6%)
Frame = +3
Query: 3 QGISTSITEKTASALLTIDLDKD---RTTQIRVKQHHESPAFCRLFGGTMVVHIG----- 158
QG ++S EK +SA+ T+ LD + + Q+RV Q +E F R+F G MV+ +G
Sbjct: 453 QGCASSQDEKASSAIHTVRLDNELCGKAVQVRVVQGYEPAHFLRIFKGRMVIFLGGKASG 512
Query: 159 ----KQQFSENVSKSRLFVIRGEIESEAHFVEVLCESQSLRERGVFLLLNIKRSKCYLWL 326
+ +V +RLF +RG + + ++ + SL VF+L K YLW+
Sbjct: 513 FKNVHDHDTYDVDGTRLFRVRGTCDFDTRAIQQTEVAGSLNSDDVFVLET--PGKTYLWI 570
Query: 327 GNCASAESRSSAFFCIKQLLAKKPIDLRITLNDIKIEEIEQGKEPRTFWEDMG 485
G AS E ++ + +K ++L D + + +G+E FW +G
Sbjct: 571 GKGASEEEKA---------MGEKVVELVSPGRD--MVTVAEGEEDDDFWGGLG 612
>sp|P09327|VILI_HUMAN Villin-1
Length = 827
Score = 62.8 bits (151), Expect = 1e-09
Identities = 51/167 (30%), Positives = 74/167 (44%), Gaps = 6/167 (3%)
Frame = +3
Query: 3 QGISTSITEKTASALLTIDLDKD---RTTQIRVKQHHESPAFCRLFGGTMVVHIGKQQFS 173
QG S E TASA + LD+ QIRV E P +F G MVV+ G +
Sbjct: 447 QGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIFKGRMVVYQGGTSRT 506
Query: 174 ENVS---KSRLFVIRGEIESEAHFVEVLCESQSLRERGVFLLLNIKRSKCYLWLGNCASA 344
N+ +RLF ++G + EV + L VF+L +S CYLW G S
Sbjct: 507 NNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKT--QSCCYLWCGKGCSG 564
Query: 345 ESRSSAFFCIKQLLAKKPIDLRITLNDIKIEEIEQGKEPRTFWEDMG 485
+ R +AK D T++ + + + +G+EP FW +G
Sbjct: 565 DERE---------MAKMVAD---TISRTEKQVVVEGQEPANFWMALG 599
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,894,308
Number of Sequences: 369166
Number of extensions: 2190003
Number of successful extensions: 4927
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4737
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4897
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9030416440
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)