Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_B08
(758 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P40427|EXD_DROME Homeobox protein extradenticle 204 3e-52
sp|P40426|PBX3_HUMAN Pre-B-cell leukemia transcription fact... 200 4e-51
sp|O35317|PBX3_MOUSE Pre-B-cell leukemia transcription fact... 200 4e-51
sp|P40425|PBX2_HUMAN Pre-B-cell leukemia transcription fact... 197 2e-50
sp|O35984|PBX2_MOUSE Pre-B-cell leukemia transcription fact... 197 2e-50
sp|P41778|PBX1_MOUSE Pre-B-cell leukemia transcription fact... 194 2e-49
sp|Q99NE9|PBX4_MOUSE Pre-B-cell leukemia transcription fact... 176 6e-44
sp|Q9BYU1|PBX4_HUMAN Pre-B-cell leukemia transcription fact... 161 2e-39
sp|P41779|HM20_CAEEL Homeobox protein ceh-20 134 2e-31
sp|Q19503|HM40_CAEEL Homeobox protein ceh-40 50 5e-06
>sp|P40427|EXD_DROME Homeobox protein extradenticle
Length = 376
Score = 204 bits (518), Expect = 3e-52
Identities = 111/180 (61%), Positives = 129/180 (71%), Gaps = 8/180 (4%)
Frame = +2
Query: 239 GRELQNILSVAHQSLDEAQERKHSLNNHRLKPALYSVFCEIKEKTSLSLRNTAQINSEDD 418
G LQ I+S++ QSLDEAQ RKH+LN HR+KPAL+SV CEIKEKT LS+RNT +
Sbjct: 44 GEILQQIMSISEQSLDEAQARKHTLNCHRMKPALFSVLCEIKEKTVLSIRNT------QE 97
Query: 419 SNSPDPQLLRLDKMLIAEGVTGNNSSNIGDIDSE-----YGGNQS---ESNQIEHADYRA 574
PDPQL+RLD MLIAEGV G G + GG+ S N IEH+DYRA
Sbjct: 98 EEPPDPQLMRLDNMLIAEGVAGPEKGGGGAAAASAAAASQGGSLSIDGADNAIEHSDYRA 157
Query: 575 KLAQIRQIYHSELEKYKNACNEFTGHVINLLREQSRSRPISPAEIELMVGIIKKKFRAIE 754
KLAQIRQIYH ELEKY+ ACNEFT HV+NLLREQSR+RPI+P EIE MV II KKF +I+
Sbjct: 158 KLAQIRQIYHQELEKYEQACNEFTTHVMNLLREQSRTRPITPKEIERMVQIIHKKFSSIQ 217
>sp|P40426|PBX3_HUMAN Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3)
Length = 434
Score = 200 bits (508), Expect = 4e-51
Identities = 107/183 (58%), Positives = 131/183 (71%), Gaps = 4/183 (2%)
Frame = +2
Query: 218 DQKIQCTGRELQNILSVAHQSLDEAQERKHSLNNHRLKPALYSVFCEIKEKTSLSLRNTA 397
D + Q G L I+++ QSLDEAQ +KH+LN HR+KPAL+SV CEIKEKT LS+R
Sbjct: 40 DGRKQDIGDILHQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGA- 98
Query: 398 QINSEDDSNSPDPQLLRLDKMLIAEGVTG----NNSSNIGDIDSEYGGNQSESNQIEHAD 565
+ + PDPQL+RLD ML+AEGV+G S+ + GG S N IEH+D
Sbjct: 99 -----QEEDPPDPQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAASGG--SSDNSIEHSD 151
Query: 566 YRAKLAQIRQIYHSELEKYKNACNEFTGHVINLLREQSRSRPISPAEIELMVGIIKKKFR 745
YRAKL QIRQIYH+ELEKY+ ACNEFT HV+NLLREQSR+RPISP EIE MVGII +KF
Sbjct: 152 YRAKLTQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFS 211
Query: 746 AIE 754
+I+
Sbjct: 212 SIQ 214
>sp|O35317|PBX3_MOUSE Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3)
Length = 434
Score = 200 bits (508), Expect = 4e-51
Identities = 107/183 (58%), Positives = 131/183 (71%), Gaps = 4/183 (2%)
Frame = +2
Query: 218 DQKIQCTGRELQNILSVAHQSLDEAQERKHSLNNHRLKPALYSVFCEIKEKTSLSLRNTA 397
D + Q G L I+++ QSLDEAQ +KH+LN HR+KPAL+SV CEIKEKT LS+R
Sbjct: 40 DGRKQDIGDILHQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGA- 98
Query: 398 QINSEDDSNSPDPQLLRLDKMLIAEGVTG----NNSSNIGDIDSEYGGNQSESNQIEHAD 565
+ + PDPQL+RLD ML+AEGV+G S+ + GG S N IEH+D
Sbjct: 99 -----QEEDPPDPQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAASGG--SSDNSIEHSD 151
Query: 566 YRAKLAQIRQIYHSELEKYKNACNEFTGHVINLLREQSRSRPISPAEIELMVGIIKKKFR 745
YRAKL QIRQIYH+ELEKY+ ACNEFT HV+NLLREQSR+RPISP EIE MVGII +KF
Sbjct: 152 YRAKLTQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFS 211
Query: 746 AIE 754
+I+
Sbjct: 212 SIQ 214
>sp|P40425|PBX2_HUMAN Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2)
(G17 protein)
Length = 430
Score = 197 bits (502), Expect = 2e-50
Identities = 104/179 (58%), Positives = 127/179 (70%), Gaps = 4/179 (2%)
Frame = +2
Query: 230 QCTGRELQNILSVAHQSLDEAQERKHSLNNHRLKPALYSVFCEIKEKTSLSLRNTAQINS 409
Q G LQ I+++ QSLDEAQ +KH+LN HR+KPAL+SV CEIKEKT LS+R S
Sbjct: 51 QDIGDILQQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIR------S 104
Query: 410 EDDSNSPDPQLLRLDKMLIAEGVTG----NNSSNIGDIDSEYGGNQSESNQIEHADYRAK 577
+ DPQL+RLD ML+AEGV G S+ + GG S N IEH+DYR+K
Sbjct: 105 SQEEEPVDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGGVSPDNSIEHSDYRSK 164
Query: 578 LAQIRQIYHSELEKYKNACNEFTGHVINLLREQSRSRPISPAEIELMVGIIKKKFRAIE 754
LAQIR IYHSELEKY+ ACNEFT HV+NLLREQSR+RP++P E+E MV II +KF AI+
Sbjct: 165 LAQIRHIYHSELEKYEQACNEFTTHVMNLLREQSRTRPVAPKEMERMVSIIHRKFSAIQ 223
>sp|O35984|PBX2_MOUSE Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2)
Length = 430
Score = 197 bits (502), Expect = 2e-50
Identities = 104/179 (58%), Positives = 127/179 (70%), Gaps = 4/179 (2%)
Frame = +2
Query: 230 QCTGRELQNILSVAHQSLDEAQERKHSLNNHRLKPALYSVFCEIKEKTSLSLRNTAQINS 409
Q G LQ I+++ QSLDEAQ +KH+LN HR+KPAL+SV CEIKEKT LS+R S
Sbjct: 51 QDIGDILQQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIR------S 104
Query: 410 EDDSNSPDPQLLRLDKMLIAEGVTG----NNSSNIGDIDSEYGGNQSESNQIEHADYRAK 577
+ DPQL+RLD ML+AEGV G S+ + GG S N IEH+DYR+K
Sbjct: 105 SQEEEPVDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGGVSPDNSIEHSDYRSK 164
Query: 578 LAQIRQIYHSELEKYKNACNEFTGHVINLLREQSRSRPISPAEIELMVGIIKKKFRAIE 754
LAQIR IYHSELEKY+ ACNEFT HV+NLLREQSR+RP++P E+E MV II +KF AI+
Sbjct: 165 LAQIRHIYHSELEKYEQACNEFTTHVMNLLREQSRTRPVAPKEMERMVSIIHRKFSAIQ 223
>sp|P41778|PBX1_MOUSE Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1)
sp|P40424|PBX1_HUMAN Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1)
(Homeobox protein PRL)
Length = 430
Score = 194 bits (494), Expect = 2e-49
Identities = 102/178 (57%), Positives = 124/178 (69%), Gaps = 3/178 (1%)
Frame = +2
Query: 230 QCTGRELQNILSVAHQSLDEAQERKHSLNNHRLKPALYSVFCEIKEKTSLSLRNTAQINS 409
Q G LQ I+++ QSLDEAQ RKH+LN HR+KPAL++V CEIKEKT LS+R
Sbjct: 41 QDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGA----- 95
Query: 410 EDDSNSPDPQLLRLDKMLIAEGVTG---NNSSNIGDIDSEYGGNQSESNQIEHADYRAKL 580
+ DPQL+RLD ML+AEGV G S + G N +EH+DYRAKL
Sbjct: 96 -QEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKL 154
Query: 581 AQIRQIYHSELEKYKNACNEFTGHVINLLREQSRSRPISPAEIELMVGIIKKKFRAIE 754
+QIRQIYH+ELEKY+ ACNEFT HV+NLLREQSR+RPISP EIE MV II +KF +I+
Sbjct: 155 SQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQ 212
>sp|Q99NE9|PBX4_MOUSE Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)
Length = 378
Score = 176 bits (446), Expect = 6e-44
Identities = 99/175 (56%), Positives = 117/175 (66%), Gaps = 2/175 (1%)
Frame = +2
Query: 236 TGRELQNILSVAHQSLDEAQERKHSLNNHRLKPALYSVFCEIKEKTSLSLRNTAQINSED 415
T LQ I+++ QSLDEAQ RKH+LN HR+K AL+SV CEIK KT++S+ Q ED
Sbjct: 27 TSDVLQQIMAITDQSLDEAQARKHALNCHRMKSALFSVLCEIKGKTAVSI----QFQEED 82
Query: 416 DSNSPDPQLLRLDKMLIAEGVTGNNSSNIGDIDSEYG--GNQSESNQIEHADYRAKLAQI 589
PD QLLRLD ML+AEGV+ G G N IEH+DYRAKL+QI
Sbjct: 83 P---PDAQLLRLDNMLLAEGVSRPEKRGRGAAAGSTATPGGCPNDNSIEHSDYRAKLSQI 139
Query: 590 RQIYHSELEKYKNACNEFTGHVINLLREQSRSRPISPAEIELMVGIIKKKFRAIE 754
RQIYHSELEKY+ AC EFT HV NLLREQSR RP+S E+E MV I+ KF AI+
Sbjct: 140 RQIYHSELEKYEQACREFTTHVTNLLREQSRVRPVSCREMEHMVNTIQSKFSAIQ 194
>sp|Q9BYU1|PBX4_HUMAN Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)
Length = 330
Score = 161 bits (407), Expect = 2e-39
Identities = 88/151 (58%), Positives = 101/151 (66%), Gaps = 4/151 (2%)
Frame = +2
Query: 314 NNHRLKPALYSVFCEIKEKTSLSLRNTAQINSEDDSNSPDPQLLRLDKMLIAEGVTGNNS 493
N HR+KPAL+SV CEIKEKT +S+R D + PD QLLRLD ML+AEGV
Sbjct: 1 NCHRMKPALFSVLCEIKEKTVVSIRGI------QDEDPPDAQLLRLDNMLLAEGVCRPEK 54
Query: 494 SNIGDIDSEYG----GNQSESNQIEHADYRAKLAQIRQIYHSELEKYKNACNEFTGHVIN 661
G + G G N IEH+DYRAKL+QIRQIYHSELEKY+ AC EFT HV N
Sbjct: 55 RGRGGAVARAGTATPGGCPNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTN 114
Query: 662 LLREQSRSRPISPAEIELMVGIIKKKFRAIE 754
LL+EQSR RP+SP EIE MVG I KF AI+
Sbjct: 115 LLQEQSRMRPVSPKEIERMVGAIHGKFSAIQ 145
>sp|P41779|HM20_CAEEL Homeobox protein ceh-20
Length = 338
Score = 134 bits (338), Expect = 2e-31
Identities = 77/170 (45%), Positives = 104/170 (61%), Gaps = 1/170 (0%)
Frame = +2
Query: 248 LQNILSVAHQSLDEAQE-RKHSLNNHRLKPALYSVFCEIKEKTSLSLRNTAQINSEDDSN 424
L +L + Q+LD+ +K L H ++ AL+ V CE KEKT L++RN D
Sbjct: 13 LDAVLKINEQTLDDNDSAKKQELQCHPMRQALFDVLCETKEKTVLTVRNQV------DET 66
Query: 425 SPDPQLLRLDKMLIAEGVTGNNSSNIGDIDSEYGGNQSESNQIEHADYRAKLAQIRQIYH 604
DPQL+RLD ML+AEGV G + G + S+ G + ADYR KL QIR +Y+
Sbjct: 67 PEDPQLMRLDNMLVAEGVAGPDKG--GSLGSDASGG-------DQADYRQKLHQIRVLYN 117
Query: 605 SELEKYKNACNEFTGHVINLLREQSRSRPISPAEIELMVGIIKKKFRAIE 754
EL KY+ ACNEFT HV +LL++QS+ RPI+ EIE MV II++KF I+
Sbjct: 118 EELRKYEEACNEFTQHVRSLLKDQSQVRPIAHKEIERMVYIIQRKFNGIQ 167
>sp|Q19503|HM40_CAEEL Homeobox protein ceh-40
Length = 329
Score = 50.4 bits (119), Expect = 5e-06
Identities = 40/170 (23%), Positives = 76/170 (44%), Gaps = 2/170 (1%)
Frame = +2
Query: 248 LQNILSVAHQSLDE--AQERKHSLNNHRLKPALYSVFCEIKEKTSLSLRNTAQINSEDDS 421
L ++ + ++D + K + + A+ V E K K LS + + ++++
Sbjct: 12 LSEVVKITDMTMDNEAVNKLKPQIKINPFYRAVQDVLVEQKSKIDLSTKMMKDLEAQEND 71
Query: 422 NSPDPQLLRLDKMLIAEGVTGNNSSNIGDIDSEYGGNQSESNQIEHADYRAKLAQIRQIY 601
RLD ML AEGV G + S + I G +Q E YR +L ++R+
Sbjct: 72 E-------RLDTMLKAEGVAGPDDSLL-RIQEAAGTDQYE--------YRQQLLKVRREL 115
Query: 602 HSELEKYKNACNEFTGHVINLLREQSRSRPISPAEIELMVGIIKKKFRAI 751
+E + + C ++ +V ++L++Q RPI+ E + + KF +
Sbjct: 116 ENETKAFDKHCKKWCEYVEDVLQQQGEFRPITQQSTEKFMNKMSGKFNKV 165
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,604,228
Number of Sequences: 369166
Number of extensions: 1249173
Number of successful extensions: 3403
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3294
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3379
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6970118400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)