Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_B07
(816 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P37276|DYHC_DROME Dynein heavy chain, cytosolic (DYHC) 192 1e-48
sp|Q9JHU4|DYHC_MOUSE Dynein heavy chain, cytosolic (DYHC) (... 178 2e-44
sp|Q14204|DYHC_HUMAN Dynein heavy chain, cytosolic (DYHC) (... 177 4e-44
sp|P38650|DYHC_RAT Dynein heavy chain, cytosolic (DYHC) (Cy... 172 1e-42
sp|Q19020|DYHC_CAEEL Dynein heavy chain, cytosolic (DYHC) 136 6e-32
sp|P34036|DYHC_DICDI Dynein heavy chain, cytosolic (DYHC) 112 2e-24
sp|Q27171|DYHC_PARTE Dynein heavy chain, cytosolic (DYHC) (... 107 5e-23
sp|Q9NYC9|DYH9_HUMAN Ciliary dynein heavy chain 9 (Axonemal... 54 5e-07
sp|P23098|DYHC_TRIGR Dynein beta chain, ciliary 53 1e-06
sp|P39057|DYHC_ANTCR Dynein beta chain, ciliary 52 1e-06
>sp|P37276|DYHC_DROME Dynein heavy chain, cytosolic (DYHC)
Length = 4639
Score = 192 bits (487), Expect = 1e-48
Identities = 109/241 (45%), Positives = 149/241 (61%), Gaps = 6/241 (2%)
Frame = -2
Query: 809 F*KRSESGSNLLLIVRKDLEDISDVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSG 630
F + SGS LL V DL+D+ +C G KK TNHHRSM++ L +GIIP W +Y + +G
Sbjct: 4403 FEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVPAG 4462
Query: 629 LTVIQWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSN 450
TVIQWI DF++RV+QL +S +GA L+ +WLGGL EAY TA RQ VAQ+N
Sbjct: 4463 CTVIQWITDFSNRVQQLQKVSQLVSQAGAKELQGFPVWLGGLLNPEAYITATRQCVAQAN 4522
Query: 449 KWALEELFLDVELGEG--KIDKNTCI--VTGLRLMGSEIVDSKTLKLSTTIYKDIDICRL 282
W+LEEL LDV + + K D+ C VTGL+L G++ +++ L L++TI D+ + L
Sbjct: 4523 SWSLEELALDVTITDAGLKNDQKDCCFGVTGLKLQGAQCKNNELL-LASTIMMDLPVTIL 4581
Query: 281 KWIRIEKFEHFEENLIRDKVCLPVYLNAARTSILFT--LYFNTTDFINDFYKRGVAILAS 108
KWI+I K+ LPVYLN+ RT +LFT L + FY+RGVA+L S
Sbjct: 4582 KWIKISSEPRI------SKLTLPVYLNSTRTELLFTVDLAVAAGQESHSFYERGVAVLTS 4635
Query: 107 S 105
+
Sbjct: 4636 T 4636
>sp|Q9JHU4|DYHC_MOUSE Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain)
Length = 4644
Score = 178 bits (451), Expect = 2e-44
Identities = 100/239 (41%), Positives = 148/239 (61%), Gaps = 5/239 (2%)
Frame = -2
Query: 809 F*KRSESGSNLLLIVRKDLEDISDVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSG 630
F + + G+ LL VR+DL D+ VC G KK TN+ R+++ L KGI+P SW Y + +G
Sbjct: 4411 FEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAG 4470
Query: 629 LTVIQWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSN 450
+TVIQW+ DF++R+KQL +IS A + GA L+++ + LGGLF+ EAY TA RQ VAQ+N
Sbjct: 4471 MTVIQWVSDFSERIKQLQNISQAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQAN 4530
Query: 449 KWALEELFLDVELGEGK---IDKNTCIVTGLRLMGSEIVDSKTLKLSTTIYKDIDICRLK 279
W+LEEL L+V + + +D + VTGL+L G+ ++K L LS I + + +L+
Sbjct: 4531 SWSLEELCLEVNVTASQSATLDACSFGVTGLKLQGATCSNNK-LSLSNAISTVLPLTQLR 4589
Query: 278 WIRIEKFEHFEENLIRDKVCLPVYLNAARTSILFTLYFN--TTDFINDFYKRGVAILAS 108
W++ E V LPVYLN R ++FT+ F T + FY+RGVA+L +
Sbjct: 4590 WVKQTSAEK-----KASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVAVLCT 4643
>sp|Q14204|DYHC_HUMAN Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain
1) (DHC1)
Length = 4646
Score = 177 bits (448), Expect = 4e-44
Identities = 100/239 (41%), Positives = 148/239 (61%), Gaps = 5/239 (2%)
Frame = -2
Query: 809 F*KRSESGSNLLLIVRKDLEDISDVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSG 630
F + + G+ LL VR+DL D+ VC G KK TN+ R+++ L KGI+P SW Y + +G
Sbjct: 4413 FEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAG 4472
Query: 629 LTVIQWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSN 450
+TVIQW+ DF++R+KQL +IS A + GA L+++ + LGGLF+ EAY TA RQ VAQ+N
Sbjct: 4473 MTVIQWVSDFSERIKQLQNISLAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQAN 4532
Query: 449 KWALEELFLDVELGEGK---IDKNTCIVTGLRLMGSEIVDSKTLKLSTTIYKDIDICRLK 279
W+LEEL L+V + + +D + VTGL+L G+ ++K L LS I + + +L+
Sbjct: 4533 SWSLEELCLEVNVTTSQGATLDACSFGVTGLKLQGATCNNNK-LSLSNAISTALPLTQLR 4591
Query: 278 WIRIEKFEHFEENLIRDKVCLPVYLNAARTSILFTLYFN--TTDFINDFYKRGVAILAS 108
W++ E V LPVYLN R ++FT+ F T + FY+RGVA+L +
Sbjct: 4592 WVKQTNTEK-----KASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVAVLCT 4645
>sp|P38650|DYHC_RAT Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain)
(MAP 1C)
Length = 4644
Score = 172 bits (435), Expect = 1e-42
Identities = 99/239 (41%), Positives = 145/239 (60%), Gaps = 5/239 (2%)
Frame = -2
Query: 809 F*KRSESGSNLLLIVRKDLEDISDVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSG 630
F + + G+ LL VR+DL D+ VC G KK TN+ R+++ L KGI+P SW Y + +G
Sbjct: 4411 FEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAG 4470
Query: 629 LTVIQWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSN 450
+TVIQW+ DF++R+KQL +IS A GA L+++ + LG LF+ EAY TA RQ VAQ+N
Sbjct: 4471 MTVIQWVSDFSERIKQLQNISQAAAAGGAKELKNIHVCLGALFVPEAYITATRQYVAQAN 4530
Query: 449 KWALEELFLDVELGEGK---IDKNTCIVTGLRLMGSEIVDSKTLKLSTTIYKDIDICRLK 279
W+LEEL L+V + + +D + VTGL+L G+ ++K L LS I + + +L+
Sbjct: 4531 SWSLEELCLEVNVTASQSTTLDACSFGVTGLKLQGATCSNNK-LSLSNAISTVLPLTQLR 4589
Query: 278 WIRIEKFEHFEENLIRDKVCLPVYLNAARTSILFTLYFN--TTDFINDFYKRGVAILAS 108
W + E V LPVYLN R ++FT+ F T + FY+RGVA+L +
Sbjct: 4590 WGKQTSAEK-----KASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVAVLCT 4643
>sp|Q19020|DYHC_CAEEL Dynein heavy chain, cytosolic (DYHC)
Length = 4568
Score = 136 bits (343), Expect = 6e-32
Identities = 80/228 (35%), Positives = 121/228 (53%)
Frame = -2
Query: 788 GSNLLLIVRKDLEDISDVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWI 609
GS LL +R+DL +IS VC KK N R++ +L KG +P W +Y + +TV+ W+
Sbjct: 4357 GSQLLKDIRRDLNEISAVCRAEKKQNNETRALAASLQKGEVPTGWKRYTVpreVTVMDWM 4416
Query: 608 HDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEEL 429
D +R+KQLI I GA L+ WLGG F EAY TA RQ VAQ+N W+LE+L
Sbjct: 4417 TDLNERLKQLIRI------GGADNLKRETFWLGGTFSPEAYITATRQQVAQANTWSLEQL 4470
Query: 428 FLDVELGEGKIDKNTCIVTGLRLMGSEIVDSKTLKLSTTIYKDIDICRLKWIRIEKFEHF 249
L + +G + ++G+ + G++ V L+L + + DI W
Sbjct: 4471 NLHIHIGRTD-STDVFRISGIDIRGAKSVGGNKLELCELVKSECDIVEFSW--------- 4520
Query: 248 EENLIRDKVCLPVYLNAARTSILFTLYFNTTDFINDFYKRGVAILASS 105
+ + D LP+YL R ++ L F+ + FY+RGVA++A+S
Sbjct: 4521 -KQDVADGTRLPLYLYGDRRQLISPLAFHLSS-ATVFYQRGVALVANS 4566
>sp|P34036|DYHC_DICDI Dynein heavy chain, cytosolic (DYHC)
Length = 4725
Score = 112 bits (279), Expect = 2e-24
Identities = 77/236 (32%), Positives = 128/236 (54%), Gaps = 5/236 (2%)
Frame = -2
Query: 809 F*KRSESGSNLLLIVRKDLEDISDVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSG 630
F + +G L+ + DL ++ ++ SG K TN+ RS+ T+++KGI+P W Y +
Sbjct: 4494 FEREISTGGKLVKKITNDLANLLELISGNIKSTNYLRSLTTSISKGIVPKEWKWYSVPET 4553
Query: 629 LTVIQWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSN 450
+++ WI DF+ R++QL IS ++ S S+++WLGGL EAY TA RQ+ +Q N
Sbjct: 4554 ISLSVWISDFSKRMQQLSEISESSDYS------SIQVWLGGLLNPEAYITATRQSASQLN 4607
Query: 449 KWALEELFLDVELGEGKIDKN---TCIVTGLRLMGSEIVDSKTLKLSTTIYKDIDICRLK 279
W+LE L L GKI + V G+ L G+ + ++ L + + I I L
Sbjct: 4608 GWSLENLRLHAS-SLGKISSEGGASFNVKGMALEGA-VWNNDQLTPTDILSTPISIATLT 4665
Query: 278 WIRIEKFEHFEENLIRDKVCLPVYLNAARTSILFT--LYFNTTDFINDFYKRGVAI 117
W +K + N K+ +PVYLN R+ +LF+ L ++ + ++Y+R V+I
Sbjct: 4666 W--KDKDDPIFNN-SSSKLSVPVYLNETRSELLFSIDLPYDQSTSKQNWYQRSVSI 4718
>sp|Q27171|DYHC_PARTE Dynein heavy chain, cytosolic (DYHC) (DHC08)
Length = 4540
Score = 107 bits (266), Expect = 5e-23
Identities = 67/206 (32%), Positives = 116/206 (56%), Gaps = 1/206 (0%)
Frame = -2
Query: 785 SNLLLIVRKDLEDISDVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVIQWIH 606
S LL VR+++E++ + G TN R + ++ I+P W KY + + + + W+
Sbjct: 4323 SKLLKAVRQNIEELIQLAQGKILATNILRQLAKDVFNNIVPAQWNKYNVIT-MPLNDWVG 4381
Query: 605 DFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELF 426
DF R+ Q + T + ++W GGL EAY TA RQ VAQ+NKW+LEEL
Sbjct: 4382 DFKRRIDQFDLLGKTK------DFQKGQVWFGGLLFPEAYLTATRQYVAQANKWSLEELE 4435
Query: 425 LDVELGEGKIDKNTCIVTGLRLMGSEIVDSKTLKLSTTIYKDIDICRLKWIRIEKFEHFE 246
L + + ID+++ ++ G+ + G + DSKTL++ I +I + LK I ++ + +
Sbjct: 4436 LQMIPEDQGIDEDSFVIEGVSMEGGHL-DSKTLQV--RIVNEISVA-LKPITLKWCKTSQ 4491
Query: 245 ENLI-RDKVCLPVYLNAARTSILFTL 171
+ ++ D++ LPVYLN R +++F+L
Sbjct: 4492 KGVVGDDEIVLPVYLNKTRKNLIFSL 4517
>sp|Q9NYC9|DYH9_HUMAN Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9)
Length = 4486
Score = 53.9 bits (128), Expect = 5e-07
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 2/121 (1%)
Frame = -2
Query: 767 VRKDLEDISDVCSGTKKPTNHHRSMMTNLAKGIIPISWIK--YPISSGLTVIQWIHDFAD 594
+++ L ++ G T+H ++ L ++P SW + YP ++GL W D +
Sbjct: 4269 IQRSLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAA--WFPDLLN 4326
Query: 593 RVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVE 414
R+K+L +G + S +WL G F +++ TAI Q+ A+ N+W L+++ L +
Sbjct: 4327 RIKEL------EAWTGDFTMPST-VWLTGFFNPQSFLTAIMQSTARKNEWPLDQIALQCD 4379
Query: 413 L 411
+
Sbjct: 4380 M 4380
>sp|P23098|DYHC_TRIGR Dynein beta chain, ciliary
Length = 4466
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 2/121 (1%)
Frame = -2
Query: 767 VRKDLEDISDVCSGTKKPTNHHRSMMTNLAKGIIPISWIK--YPISSGLTVIQWIHDFAD 594
+R+ L+++ G T + L IP +W+K YP GLT W D
Sbjct: 4249 IRRSLKELDLGLKGELTITPDMEDLSNALFLDQIPATWVKRAYPSLFGLT--SWYADLLQ 4306
Query: 593 RVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVE 414
R+K+L + L +V +WLGG F +++ TAI Q++A+ N+W L+++ L +
Sbjct: 4307 RIKELEQWT------ADFALPNV-VWLGGFFNPQSFLTAIMQSMARKNEWPLDKMCLQCD 4359
Query: 413 L 411
+
Sbjct: 4360 V 4360
>sp|P39057|DYHC_ANTCR Dynein beta chain, ciliary
Length = 4466
Score = 52.4 bits (124), Expect = 1e-06
Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 2/121 (1%)
Frame = -2
Query: 767 VRKDLEDISDVCSGTKKPTNHHRSMMTNLAKGIIPISWIK--YPISSGLTVIQWIHDFAD 594
+R+ L+++ G T + L IP SW+K YP GL+ W D
Sbjct: 4249 IRRSLKELDLGLKGELTITPDMEDLSNALFLDQIPASWVKRAYPSLFGLSA--WYADLLQ 4306
Query: 593 RVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWALEELFLDVE 414
R+K+L + L +V +WLGG F +++ TAI Q++A+ N+W L+++ L +
Sbjct: 4307 RIKELEQWT------ADFALPNV-VWLGGFFNPQSFLTAIMQSMARKNEWPLDKMCLQCD 4359
Query: 413 L 411
+
Sbjct: 4360 V 4360
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,133,366
Number of Sequences: 369166
Number of extensions: 1543438
Number of successful extensions: 3935
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3829
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3914
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7811456130
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)