Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_P05
(886 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q91ZT5|FGD4_MOUSE FYVE, RhoGEF and PH domain containing ... 87 8e-17
sp|Q96M96|FGD4_HUMAN FYVE, RhoGEF and PH domain containing ... 86 1e-16
sp|O88387|FGD4_RAT FYVE, RhoGEF and PH domain containing pr... 86 1e-16
sp|Q8BY35|FGD2_MOUSE FYVE, RhoGEF and PH domain containing ... 85 3e-16
sp|Q7Z6J4|FGD2_HUMAN FYVE, RhoGEF and PH domain containing ... 84 7e-16
sp|P98174|FGD1_HUMAN FYVE, RhoGEF and PH domain containing ... 79 1e-14
sp|P52734|FGD1_MOUSE FYVE, RhoGEF and PH domain containing ... 78 3e-14
sp|Q6ZV73|FGD6_HUMAN FYVE, RhoGEF and PH domain containing ... 67 5e-11
sp|O95405|ZFYV9_HUMAN Zinc finger FYVE domain-containing pr... 66 1e-10
sp|Q69ZL1|FGD6_MOUSE FYVE, RhoGEF and PH domain containing ... 65 3e-10
>sp|Q91ZT5|FGD4_MOUSE FYVE, RhoGEF and PH domain containing protein 4 (Actin-binding
protein frabin) (FGD1-related F-actin-binding protein)
Length = 766
Score = 86.7 bits (213), Expect = 8e-17
Identities = 62/214 (28%), Positives = 97/214 (45%), Gaps = 15/214 (7%)
Frame = +2
Query: 59 NVNTKFIAKGLVTKYSKKNNTELSRQLVLFSDYLYVTTPTHH-VNETSKVRQELSLKYMN 235
N + + I +G + K + +N + R L LF++ L P V VR + + M
Sbjct: 418 NPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMK 477
Query: 236 VSPISMDENERSSSMFGLTINTKESNLEFYFEDENTLNVWMERLESAID----------- 382
+ +E + + G KE LE E W++ L+ +ID
Sbjct: 478 IVETHNEEYPHTFQISG-----KERTLELQASSEQDKEEWIKALQESIDAFHQRHETFRN 532
Query: 383 -VLKKFINPSKVPT-NLGEIAPEWQKDESCGYCNGFKCCKKFTAFSRR-HHCRADGLIYC 553
+ K+ P +V T LG+ AP W +D C KC + F A +RR HHCRA G + C
Sbjct: 533 AIAKENDIPLEVSTAELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGHVVC 590
Query: 554 DQCSIYRVKLKYERSDWSRVCNLCYIIIHSKNDA 655
+CS Y+ +L+Y+ ++VC CY II D+
Sbjct: 591 WKCSDYKAQLEYDGGRLNKVCKDCYQIISGFTDS 624
>sp|Q96M96|FGD4_HUMAN FYVE, RhoGEF and PH domain containing protein 4 (Actin-filament
binding protein frabin) (FGD1-related F-actin-binding
protein) (Zinc finger FYVE domain containing protein 6)
Length = 766
Score = 85.9 bits (211), Expect = 1e-16
Identities = 68/249 (27%), Positives = 109/249 (43%), Gaps = 15/249 (6%)
Frame = +2
Query: 59 NVNTKFIAKGLVTKYSKKNNTELSRQLVLFSDYLYVTTPTHH-VNETSKVRQELSLKYMN 235
N + + I +G + K + +N + R L LF++ L P V VR + + M
Sbjct: 418 NPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMK 477
Query: 236 VSPISMDENERSSSMFGLTINTKESNLEFYFEDENTLNVWMERLESAIDVLKK----FIN 403
+ +E + + G KE LE W++ L+ ID + F N
Sbjct: 478 IVETQNEEYPHTFQVSG-----KERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRN 532
Query: 404 P--------SKVPT-NLGEIAPEWQKDESCGYCNGFKCCKKFTAFSRR-HHCRADGLIYC 553
S+V T LG+ AP W +D C KC + F A +RR HHCRA G + C
Sbjct: 533 AIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMC--MKCKEPFNALTRRRHHCRACGYVVC 590
Query: 554 DQCSIYRVKLKYERSDWSRVCNLCYIIIHSKNDATISESEVVEAKNQLNIVFERITRKGA 733
+CS Y+ +L+Y+ S+VC CY II + ++SE + K L I ++
Sbjct: 591 WKCSDYKAQLEYDGGKLSKVCKDCYQII-----SGFTDSEEKKRKGILEIESAEVSGNSV 645
Query: 734 KMGWLKFSD 760
+L++ +
Sbjct: 646 VCSFLQYME 654
>sp|O88387|FGD4_RAT FYVE, RhoGEF and PH domain containing protein 4 (Actin-filament
binding protein frabin) (FGD1-related F-actin-binding
protein)
Length = 766
Score = 85.9 bits (211), Expect = 1e-16
Identities = 66/249 (26%), Positives = 111/249 (44%), Gaps = 15/249 (6%)
Frame = +2
Query: 59 NVNTKFIAKGLVTKYSKKNNTELSRQLVLFSDYLYVTTPTHH-VNETSKVRQELSLKYMN 235
N + + I +G + K + +N + R L LF++ L P V VR + + M
Sbjct: 418 NPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMK 477
Query: 236 VSPISMDENERSSSMFGLTINTKESNLEFYFEDENTLNVWMERLESAID----------- 382
+ +E + + G KE LE E W++ L+ +ID
Sbjct: 478 IVETHNEEYPHTFQVSG-----KERTLELQASSEQDKEEWIKALQESIDAFHQRHETFRN 532
Query: 383 -VLKKFINPSKVPT-NLGEIAPEWQKDESCGYCNGFKCCKKFTAFSRR-HHCRADGLIYC 553
+ K+ P +V T LG+ AP W +D C KC + F A +RR HHCRA G + C
Sbjct: 533 AIAKENDIPLEVSTAELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGHVVC 590
Query: 554 DQCSIYRVKLKYERSDWSRVCNLCYIIIHSKNDATISESEVVEAKNQLNIVFERITRKGA 733
+CS Y+ +L+Y+ ++VC CY I+ + +ESE + + L I ++
Sbjct: 591 WKCSDYKAQLEYDGGRLNKVCKDCYQIM-----SGFAESEEKKRRGILEIESAEVSGNSE 645
Query: 734 KMGWLKFSD 760
+L++ +
Sbjct: 646 VCSFLQYME 654
>sp|Q8BY35|FGD2_MOUSE FYVE, RhoGEF and PH domain containing protein 2
Length = 655
Score = 84.7 bits (208), Expect = 3e-16
Identities = 60/204 (29%), Positives = 94/204 (46%), Gaps = 17/204 (8%)
Frame = +2
Query: 77 IAKGLVTKYSKKNNTELSRQLVLFSDYLYVTTP-THHVNETSKVRQELSLKYMNVSPISM 253
+ +G V K S + + + R LVLF++ L P V +VR + + M V ++
Sbjct: 321 LREGPVLKISFRRSDPMERYLVLFNNMLLYCVPRVLQVGAQFQVRTRIDVAGMKVRELTD 380
Query: 254 DENERSSSMFGLTINTKESNLEFYFEDENTLNVWMERLESAIDVLKKFINPSKVPTN--- 424
E S + G K+ LE + + WM+ ++AID ++K K
Sbjct: 381 AEFPHSFLVSG-----KQRTLELQARSRDEMVSWMQACQAAIDQVEKRSETFKAAVQGPQ 435
Query: 425 ------------LGEIAPEWQKDESCGYCNGFKCCKKFTAFSRR-HHCRADGLIYCDQCS 565
LG AP+W +D+ C +C + F A +RR HHCRA G + C +CS
Sbjct: 436 GDTQEPKPQVEELGLRAPQWVRDKMVTMC--MRCQEPFNALTRRRHHCRACGYVVCAKCS 493
Query: 566 IYRVKLKYERSDWSRVCNLCYIII 637
YR +LKY+ + +RVC CY +
Sbjct: 494 DYRAELKYDSNRPNRVCLTCYTFL 517
>sp|Q7Z6J4|FGD2_HUMAN FYVE, RhoGEF and PH domain containing protein 2 (Zinc finger FYVE
domain containing protein 4)
Length = 655
Score = 83.6 bits (205), Expect = 7e-16
Identities = 60/204 (29%), Positives = 92/204 (45%), Gaps = 17/204 (8%)
Frame = +2
Query: 77 IAKGLVTKYSKKNNTELSRQLVLFSDYLYVTTP-THHVNETSKVRQELSLKYMNVSPISM 253
+ +G V K S + N + R L LF++ L P V +VR + + M V +
Sbjct: 321 LREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMD 380
Query: 254 DENERSSSMFGLTINTKESNLEFYFEDENTLNVWMERLESAIDVLKKFINPSKVPTN--- 424
E S + G K+ LE + + WM+ ++AID ++K K
Sbjct: 381 AEFPHSFLVSG-----KQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPE 435
Query: 425 ------------LGEIAPEWQKDESCGYCNGFKCCKKFTAFSRR-HHCRADGLIYCDQCS 565
LG AP+W +D+ C +C + F A +RR HHCRA G + C +CS
Sbjct: 436 GDIQEQELQSEELGLRAPQWVRDKMVTMC--MRCQEPFNALTRRRHHCRACGYVVCARCS 493
Query: 566 IYRVKLKYERSDWSRVCNLCYIII 637
YR +LKY+ + +RVC CY +
Sbjct: 494 DYRAELKYDDNRPNRVCLHCYAFL 517
>sp|P98174|FGD1_HUMAN FYVE, RhoGEF and PH domain containing protein 1 (Faciogenital
dysplasia 1 protein) (Zinc finger FYVE domain containing
protein 3) (Rho/Rac guanine nucleotide exchange factor
FGD1) (Rho/Rac GEF)
Length = 961
Score = 79.3 bits (194), Expect = 1e-14
Identities = 65/261 (24%), Positives = 116/261 (44%), Gaps = 34/261 (13%)
Frame = +2
Query: 71 KFIAKGLVTKYSKKNNTELSRQLVLFSDYLYVTTPTHHVNETSKVRQELSLKY-MNVSPI 247
+ I +G + K S KN T R L+LF+D L P + + Q+ S++ ++V +
Sbjct: 590 ELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRL-----LGQKFSVRARIDVDGM 644
Query: 248 SMDENERSSSMFGLTINTKESNLEFYFEDENTLNVWMERLESAIDVLK--------KFIN 403
+ E+ + ++ K+ +LE E W++ + S + LK K +N
Sbjct: 645 ELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTL--LKHEQTLETFKLLN 702
Query: 404 ----------PSKVPTNLGEIAPEWQKDESCGYCNGFKCCKKFTAFS-RRHHCRADGLIY 550
P+ +LG+ AP +++ C +C + F + + RRHHC+A G +
Sbjct: 703 STNREDEDTPPNSPNVDLGKRAPTPIREKEVTMC--MRCQEPFNSITKRRHHCKACGHVV 760
Query: 551 CDQCSIYRVKLKYERSDWSRVCNLCYIIIH--------------SKNDATISESEVVEAK 688
C +CS +R +L Y+ + +RVC CY+ +H + + + + V A+
Sbjct: 761 CGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAAE 820
Query: 689 NQLNIVFERITRKGAKMGWLK 751
N + F KG K GW K
Sbjct: 821 NSVICSFLHYMEKGGK-GWHK 840
>sp|P52734|FGD1_MOUSE FYVE, RhoGEF and PH domain containing protein 1 (Faciogenital
dysplasia 1 protein homolog) (Zinc finger FYVE domain
containing protein 3) (Rho/Rac guanine nucleotide
exchange factor FGD1) (Rho/Rac GEF)
Length = 960
Score = 78.2 bits (191), Expect = 3e-14
Identities = 64/261 (24%), Positives = 116/261 (44%), Gaps = 34/261 (13%)
Frame = +2
Query: 71 KFIAKGLVTKYSKKNNTELSRQLVLFSDYLYVTTPTHHVNETSKVRQELSLKY-MNVSPI 247
+ I +G + K S KN T R L+LF+D L P + + Q+ +++ ++V +
Sbjct: 589 ELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRL-----LGQKFTVRARIDVDGM 643
Query: 248 SMDENERSSSMFGLTINTKESNLEFYFEDENTLNVWMERLESAIDVLK--------KFIN 403
+ E+ + ++ K+ +LE E W++ + S + LK K +N
Sbjct: 644 ELKESSNLNMPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTL--LKHEQTLETFKLLN 701
Query: 404 ----------PSKVPTNLGEIAPEWQKDESCGYCNGFKCCKKFTAFS-RRHHCRADGLIY 550
P+ +LG+ AP +++ C +C + F + + RRHHC+A G +
Sbjct: 702 STNRDDEDTPPNSPNVDLGKRAPTPIREKEVTMC--MRCQEPFNSITKRRHHCKACGHVV 759
Query: 551 CDQCSIYRVKLKYERSDWSRVCNLCYIIIH--------------SKNDATISESEVVEAK 688
C +CS +R +L Y+ + +RVC CY+ +H + + + + V A+
Sbjct: 760 CGKCSEFRARLIYDNNRSNRVCTDCYVALHGAPGSSPACSQHTPQRRRSILEKQASVAAE 819
Query: 689 NQLNIVFERITRKGAKMGWLK 751
N + F KG K GW K
Sbjct: 820 NSVICSFLHYMEKGGK-GWHK 839
>sp|Q6ZV73|FGD6_HUMAN FYVE, RhoGEF and PH domain containing protein 6 (Zinc finger FYVE
domain containing protein 24)
Length = 1430
Score = 67.4 bits (163), Expect = 5e-11
Identities = 63/221 (28%), Positives = 90/221 (40%), Gaps = 14/221 (6%)
Frame = +2
Query: 8 INTHHELQLLSSRTVNHNVNTKFIAKGLVTKYSKKNNTELSRQLVLFSDYLYVTTPTHHV 187
+N HHE+ F+ +G++ K S+K R LF+D L TTP
Sbjct: 1077 LNGHHEIV---------QPGRVFLKEGILMKLSRK--VMQPRMFFLFNDALLYTTPVQ-- 1123
Query: 188 NETSKVRQELSLKYMNVSPISMDENERSSSMFGLTINTKESNLEFYFEDENTLNVWMERL 367
+ K+ LSL M V + + + L I + E + + W+E +
Sbjct: 1124 SGMYKLNNMLSLAGMKVRKPTQEAYQNE-----LKIESVERSFILSASSATERDEWLEAI 1178
Query: 368 ESAID-VLKKFIN--PSKV-----------PTNLGEIAPEWQKDESCGYCNGFKCCKKFT 505
AI+ KK I PS+ + LG AP W D C C +FT
Sbjct: 1179 SRAIEEYAKKRITFCPSRSLDEADSENKEEVSPLGSKAPIWIPDTRATMC--MICTSEFT 1236
Query: 506 AFSRRHHCRADGLIYCDQCSIYRVKLKYERSDWSRVCNLCY 628
RRHHCRA G I C CS + L Y ++ +RVC C+
Sbjct: 1237 LTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEHCF 1277
>sp|O95405|ZFYV9_HUMAN Zinc finger FYVE domain-containing protein 9 (Mothers against
decapentaplegic homolog interacting protein)
(Madh-interacting protein) (Smad anchor for receptor
activation) (Receptor activation anchor) (hSARA) (Novel
serine protease) (NSP)
Length = 1425
Score = 65.9 bits (159), Expect = 1e-10
Identities = 32/80 (40%), Positives = 43/80 (53%)
Frame = +2
Query: 398 INPSKVPTNLGEIAPEWQKDESCGYCNGFKCCKKFTAFSRRHHCRADGLIYCDQCSIYRV 577
I+ K T LGE+AP W D C KC +FT RRHHCRA G ++C C +
Sbjct: 680 ISARKPFTTLGEVAPVWVPDSQAPNC--MKCEARFTFTKRRHHCRACGKVFCASCCSLKC 737
Query: 578 KLKYERSDWSRVCNLCYIII 637
KL Y +RVC +C+ ++
Sbjct: 738 KLLYMDRKEARVCVICHSVL 757
>sp|Q69ZL1|FGD6_MOUSE FYVE, RhoGEF and PH domain containing protein 6
Length = 1399
Score = 65.1 bits (157), Expect = 3e-10
Identities = 59/198 (29%), Positives = 83/198 (41%), Gaps = 13/198 (6%)
Frame = +2
Query: 74 FIAKGLVTKYSKKNNTELSRQLVLFSDYLYVTTPTHHVNETSKVRQELSLKYMNVSPISM 253
F+ +G + K S+K R LF+D L TTP + K+ LSL M V +
Sbjct: 1060 FLKEGTLMKLSRK--VMQPRMFFLFNDALLYTTPMQ--SGMYKLNNMLSLAGMKVRKPTQ 1115
Query: 254 DENERSSSMFGLTINTKESNLEFYFEDENTLNVWMERLESAID-VLKKFIN--PSKV--- 415
+ + L I + E + + W+E + S+I+ KK I PS+
Sbjct: 1116 EAYQNE-----LKIESVERSFILSASSAAERDDWLEAISSSIEEYAKKRITFCPSRSLDE 1170
Query: 416 -------PTNLGEIAPEWQKDESCGYCNGFKCCKKFTAFSRRHHCRADGLIYCDQCSIYR 574
+ LG AP W D C C +FT RRHHCRA G I C CS +
Sbjct: 1171 DSERKEEVSPLGAKAPIWIPDTRATMC--MICTSEFTLTWRRHHCRACGKIVCQACSSNK 1228
Query: 575 VKLKYERSDWSRVCNLCY 628
L Y + +RVC C+
Sbjct: 1229 YGLDYLKGQLARVCEHCF 1246
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,277,415
Number of Sequences: 369166
Number of extensions: 1629506
Number of successful extensions: 4153
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4041
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4135
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8838279920
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)