Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_P04
(690 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9BY32|ITPA_HUMAN Inosine triphosphate pyrophosphatase (... 148 1e-35
sp|Q9D892|ITPA_MOUSE Inosine triphosphate pyrophosphatase (... 145 1e-34
sp|P47119|HAM1_YEAST HAM1 protein 119 6e-27
sp|Q57679|NTPA_METJA Nucleoside-triphosphatase (Nucleoside ... 101 2e-21
sp|Q8TV07|HAM1_METKA HAM1 protein homolog 91 3e-18
sp|Q8TJS1|HAM1_METAC HAM1 protein homolog 87 5e-17
sp|Q8PZ91|HAM1_METMA HAM1 protein homolog 84 3e-16
sp|Q8A327|HAM1_BACTN HAM1 protein homolog 82 1e-15
sp|Q5JEX8|HAM1_PYRKO HAM1 protein homolog 79 9e-15
sp|Q8U446|HAM1_PYRFU HAM1 protein homolog 78 2e-14
>sp|Q9BY32|ITPA_HUMAN Inosine triphosphate pyrophosphatase (ITPase) (Inosine
triphosphatase) (Putative oncogene protein hlc14-06-p)
Length = 194
Score = 148 bits (374), Expect = 1e-35
Identities = 84/190 (44%), Positives = 113/190 (59%)
Frame = +2
Query: 41 KITFISGNSKKISEMKSILGNDNKIKIMSQSIDIPEYQEEIIEISLLKAKYAYSIIKEPV 220
KI F++GN+KK+ E+ ILG+ +++Q ID+PEYQ E EIS+ K + A ++ PV
Sbjct: 9 KIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAVRQVQGPV 68
Query: 221 FVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKMLVGFNDFRAEAVTIISYYD 400
VEDT LCFNAL G+PGPYIKWF+ EK K +GL ++L GF D A A+ +
Sbjct: 69 LVEDTCLCFNALGGLPGPYIKWFL-----EKLKP-EGLHQLLAGFEDKSAYALCTFALST 122
Query: 401 PKIMQDPKAFIGKMLGEIVEPRGPMDFDWDCVFQPVAQCQDTLQTYAEMDYKYKNKISNR 580
Q + F G+ G IV PRG DF WD FQP QTYAEM KN +S+R
Sbjct: 123 GDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQP----DGYEQTYAEMPKAEKNAVSHR 178
Query: 581 YNAAQEFKKF 610
+ A E +++
Sbjct: 179 FRALLELQEY 188
>sp|Q9D892|ITPA_MOUSE Inosine triphosphate pyrophosphatase (ITPase) (Inosine
triphosphatase)
Length = 198
Score = 145 bits (366), Expect = 1e-34
Identities = 83/190 (43%), Positives = 113/190 (59%)
Frame = +2
Query: 41 KITFISGNSKKISEMKSILGNDNKIKIMSQSIDIPEYQEEIIEISLLKAKYAYSIIKEPV 220
KI F++GN+KK+ E+ ILG++ + +Q ID+PEYQ E EIS+ K + A ++ PV
Sbjct: 9 KIVFVTGNAKKLEEVIQILGDNFPCTLEAQKIDLPEYQGEPDEISIQKCREAARQVQGPV 68
Query: 221 FVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKMLVGFNDFRAEAVTIISYYD 400
VEDT LCFNAL G+PGPYIKWF+ +K K +GL ++L GF D A A+ +
Sbjct: 69 LVEDTCLCFNALGGLPGPYIKWFL-----QKLKP-EGLHQLLAGFEDKSAYALCTFALST 122
Query: 401 PKIMQDPKAFIGKMLGEIVEPRGPMDFDWDCVFQPVAQCQDTLQTYAEMDYKYKNKISNR 580
Q F G+ G+IV PRG DF WD FQP QTYAEM KN IS+R
Sbjct: 123 GDPSQPVLLFRGQTSGQIVMPRGSRDFGWDPCFQP----DGYEQTYAEMPKSEKNTISHR 178
Query: 581 YNAAQEFKKF 610
+ A + +++
Sbjct: 179 FRALHKLQEY 188
>sp|P47119|HAM1_YEAST HAM1 protein
Length = 197
Score = 119 bits (299), Expect = 6e-27
Identities = 77/202 (38%), Positives = 117/202 (57%), Gaps = 8/202 (3%)
Frame = +2
Query: 41 KITFISGNSKKISEMKSIL-----GNDNKIKIMSQSIDIPEYQE-EIIEISLLKAKYAYS 202
+I F++GN+ K+ E++SIL N+ I ++++++D+ E Q+ ++ I+L K K A +
Sbjct: 5 EIVFVTGNANKLKEVQSILTQEVDNNNKTIHLINEALDLEELQDTDLNAIALAKGKQAVA 64
Query: 203 IIKE--PVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKMLVGFNDFRAEA 376
+ + PVFVEDT+L F+ G+PG YIKWF+ K L+ + KML F + AEA
Sbjct: 65 ALGKGKPVFVEDTALRFDEFNGLPGAYIKWFL------KSMGLEKIVKMLEPFENKNAEA 118
Query: 377 VTIISYYDPKIMQDPKAFIGKMLGEIVEPRGPMDFDWDCVFQPVAQCQDTLQTYAEMDYK 556
VT I + D + + F G G+IV RGP F WD +F+P TYAEM
Sbjct: 119 VTTICFADSR--GEYHFFQGITRGKIVPSRGPTTFGWDSIFEPF---DSHGLTYAEMSKD 173
Query: 557 YKNKISNRYNAAQEFKKFLLEN 622
KN IS+R A +FK++L +N
Sbjct: 174 AKNAISHRGKAFAQFKEYLYQN 195
>sp|Q57679|NTPA_METJA Nucleoside-triphosphatase (Nucleoside triphosphate
phosphohydrolase) (NTPase)
Length = 193
Score = 101 bits (252), Expect = 2e-21
Identities = 67/196 (34%), Positives = 107/196 (54%)
Frame = +2
Query: 32 DMVKITFISGNSKKISEMKSILGNDNKIKIMSQSIDIPEYQEEIIEISLLKAKYAYSIIK 211
+++KI F +GN KI E IL + ++I I PE Q + E++ AK+ Y+I+K
Sbjct: 7 EIMKIYFATGNPNKIKEANIILKDLKDVEIEQIKISYPEIQGTLEEVAEFGAKWVYNILK 66
Query: 212 EPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKMLVGFNDFRAEAVTIIS 391
+PV VED+ AL G PG Y K FV + +G+ K+L G ++ A T+I
Sbjct: 67 KPVIVEDSGFFVEALNGFPGTYSK-FVQETIGN-----EGILKLLEGKDNRNAYFKTVIG 120
Query: 392 YYDPKIMQDPKAFIGKMLGEIVEPRGPMDFDWDCVFQPVAQCQDTLQTYAEMDYKYKNKI 571
Y D ++ K + + E + +G F +D +F P ++ +T+AEM + K++I
Sbjct: 121 YCDENGVRLFKGIVKGRVSEEIRSKG-YGFAYDSIFIP----EEEERTFAEMTTEEKSQI 175
Query: 572 SNRYNAAQEFKKFLLE 619
S+R A +EFKKFLL+
Sbjct: 176 SHRKKAFEEFKKFLLD 191
>sp|Q8TV07|HAM1_METKA HAM1 protein homolog
Length = 188
Score = 90.9 bits (224), Expect = 3e-18
Identities = 65/199 (32%), Positives = 101/199 (50%), Gaps = 4/199 (2%)
Frame = +2
Query: 38 VKITFISGNSKKISEMKSILGNDNKIKIMSQSIDIPEYQEEIIE-ISLLKAKYAYSIIKE 214
+K+ F +GN K E K IL I++ +D PE Q + +E I+ A+Y + +
Sbjct: 1 MKVLFATGNIGKYHEAKQILARYG-IEVERVDLDYPELQSDSLEEIAAYGARYCAESLGQ 59
Query: 215 PVFVEDTSLCFNALYGMPGPYIKWFVH--GNLDEKFKKLQGLRKMLVGFNDFRAEAVTII 388
PV VED+ L AL G PGPY + GN +G+ K+L G + +AE ++++
Sbjct: 60 PVIVEDSGLFIEALNGFPGPYSAYVFDTIGN--------EGILKLLEGEENRKAEFISVV 111
Query: 389 SYYDPKIMQDPKAFIGKMLGEIV-EPRGPMDFDWDCVFQPVAQCQDTLQTYAEMDYKYKN 565
Y +P P F G++ G I EPRG F +D +F P + T+AE+ + K
Sbjct: 112 GYCEPG--GRPVTFTGEIRGRIAEEPRGEEGFGYDPIFIPEGED----STFAELGVEEKC 165
Query: 566 KISNRYNAAQEFKKFLLEN 622
KIS+R A + F ++ N
Sbjct: 166 KISHRTKALERFAEWYKNN 184
>sp|Q8TJS1|HAM1_METAC HAM1 protein homolog
Length = 184
Score = 86.7 bits (213), Expect = 5e-17
Identities = 64/191 (33%), Positives = 102/191 (53%), Gaps = 2/191 (1%)
Frame = +2
Query: 35 MVKITFISGNSKKISEMKSILGNDNKIKIMSQSIDIPEYQEEIIE-ISLLKAKYAYSIIK 211
M KI F++GN K +E++ IL I+++ + PE QE+ +E I+ A+Y + +
Sbjct: 1 MHKIVFVTGNKGKFAEIRDILKTFG-IEVIQEKNGYPELQEDELEPIAAHGAQYVANKLN 59
Query: 212 EPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKMLVGFNDFRAEAVTIIS 391
PV V+D+ + NAL G PGPY ++ +++K L+ L KM+ G D A T+I
Sbjct: 60 MPVMVDDSGIFINALNGFPGPYSRF-----VEDKLGNLKVL-KMMEGEEDRTAYFKTVIG 113
Query: 392 YYDPKIMQDPKAFIGKMLGEIV-EPRGPMDFDWDCVFQPVAQCQDTLQTYAEMDYKYKNK 568
Y +P ++P F G + G+I E RG F +D +F+ T+ E+ KNK
Sbjct: 114 YCEPG--KEPLVFPGVVEGKIAYEERGTGGFGYDPIFEYQG------LTFGELGDTEKNK 165
Query: 569 ISNRYNAAQEF 601
+S+R A EF
Sbjct: 166 VSHRRRAVDEF 176
>sp|Q8PZ91|HAM1_METMA HAM1 protein homolog
Length = 184
Score = 84.3 bits (207), Expect = 3e-16
Identities = 64/196 (32%), Positives = 100/196 (51%), Gaps = 2/196 (1%)
Frame = +2
Query: 35 MVKITFISGNSKKISEMKSILGNDNKIKIMSQSIDIPEYQEEIIE-ISLLKAKYAYSIIK 211
M KI F++GN K +E++ IL N I+ + PE QE+ +E I+ A+Y + +
Sbjct: 1 MHKIVFVTGNKGKFAEVRDILKNFG-IEAIQNKDGYPELQEDELEPIAANGAQYVANKLN 59
Query: 212 EPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKMLVGFNDFRAEAVTIIS 391
PV V+D+ + NAL G PGPY + FV L + K++ G D A T+I
Sbjct: 60 MPVMVDDSGIFINALNGFPGPYSR-FVEDKLGN-----PKVLKLMEGEKDRSAYFKTVIG 113
Query: 392 YYDPKIMQDPKAFIGKMLGEIV-EPRGPMDFDWDCVFQPVAQCQDTLQTYAEMDYKYKNK 568
Y +P Q+P F G + G+I E RG F +D +F+ T+ E+ + KNK
Sbjct: 114 YCEPG--QEPLVFPGVVEGKIAYEERGTGGFGYDPIFEYNG------MTFGELGDEEKNK 165
Query: 569 ISNRYNAAQEFKKFLL 616
+S+R A F ++ +
Sbjct: 166 VSHRRRAVDNFLEWFI 181
>sp|Q8A327|HAM1_BACTN HAM1 protein homolog
Length = 193
Score = 82.4 bits (202), Expect = 1e-15
Identities = 64/199 (32%), Positives = 105/199 (52%), Gaps = 8/199 (4%)
Frame = +2
Query: 41 KITFISGNSKKISEMKSILGNDNKIKIMSQS-----IDIPEYQEEIIEISLLKAKYAYSI 205
K+ F + N+ K+ E+ +ILG+ K++++S + DIPE E + +LLK+ + Y
Sbjct: 4 KLVFATNNAHKLEEIAAILGD--KVELLSLNDIDCHTDIPETAETLEGNALLKSSFIYRN 61
Query: 206 IKEPVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKMLVGFNDFRAEAVTI 385
+ F +DT L AL G PG Y + G + ++ L L G + +A+ T
Sbjct: 62 YQLDCFADDTGLEVEALNGAPGVYSARYAEGEGHDAQANMRKLLHELEGKENRKAQFRTA 121
Query: 386 ISYYDPKIMQDPKAFI--GKMLGEIV-EPRGPMDFDWDCVFQPVAQCQDTLQTYAEMDYK 556
IS ++ D K ++ G + GEI+ E RG F +D +F+P + QT+AE+ +
Sbjct: 122 IS-----LILDGKEYLFEGVIKGEIIKEKRGDSGFGYDPIFKP----EGYEQTFAELGNE 172
Query: 557 YKNKISNRYNAAQEFKKFL 613
KNKIS+R A Q+ +FL
Sbjct: 173 TKNKISHRALAVQKLCEFL 191
>sp|Q5JEX8|HAM1_PYRKO HAM1 protein homolog
Length = 184
Score = 79.3 bits (194), Expect = 9e-15
Identities = 57/197 (28%), Positives = 101/197 (51%), Gaps = 2/197 (1%)
Frame = +2
Query: 38 VKITFISGNSKKISEMKSILGNDNKIKIMSQSIDIPEYQEEIIE-ISLLKAKYAYSIIKE 214
+++ F++ N K+ E + +++ + PE Q + +E ++ AK+ +
Sbjct: 1 MRLAFVTSNPGKVEEARKYF-EPLGVEVYQLKVSYPEIQADTLEEVAEYGAKWLAQRVDG 59
Query: 215 PVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKMLVGFNDFRAEAVTIISY 394
P F++D+ L AL G PG Y + K QG+ K+L G + +A ++I+Y
Sbjct: 60 PFFLDDSGLFVEALKGFPGVYSAYVY------KTIGYQGILKLLQGEKNRKAHFKSVIAY 113
Query: 395 YDPKIMQDPKAFIGKMLGEIV-EPRGPMDFDWDCVFQPVAQCQDTLQTYAEMDYKYKNKI 571
+D ++ F G++ G+I EPRG F +D +F P + +T+AEM + KN+I
Sbjct: 114 WDGEL----HIFTGRVDGKIATEPRGSGGFGFDPIFIP----EGFDRTFAEMTTEEKNRI 165
Query: 572 SNRYNAAQEFKKFLLEN 622
S+R A +EF +L EN
Sbjct: 166 SHRGRALREFANWLKEN 182
>sp|Q8U446|HAM1_PYRFU HAM1 protein homolog
Length = 185
Score = 78.2 bits (191), Expect = 2e-14
Identities = 56/197 (28%), Positives = 99/197 (50%), Gaps = 2/197 (1%)
Frame = +2
Query: 38 VKITFISGNSKKISEMKSILGNDNKIKIMSQSIDIPEYQEEIIE-ISLLKAKYAYSIIKE 214
+++ FI+ N K+ E K L I ++ + ++ PE Q + +E + + + + +
Sbjct: 1 MELFFITSNDGKVREAKKFL-EPLGINVIKKPLEYPEIQADTLEDVVVFGLNWLKDKVDK 59
Query: 215 PVFVEDTSLCFNALYGMPGPYIKWFVHGNLDEKFKKLQGLRKMLVGFNDFRAEAVTIISY 394
P +ED+ L AL G PG Y + K L G+ K++ G + +A ++I +
Sbjct: 60 PFIIEDSGLFIEALNGFPGVYSAYVY------KTIGLDGILKLMEGIENRKAYFKSVIGF 113
Query: 395 YDPKIMQDPKAFIGKMLGEIV-EPRGPMDFDWDCVFQPVAQCQDTLQTYAEMDYKYKNKI 571
YD +I F+G++ G I E RG F +D +F P +T+AEM + KN +
Sbjct: 114 YDGEI----HLFVGEVRGRISNEKRGLHGFGYDPIFVP----DGFDKTFAEMSTEEKNSV 165
Query: 572 SNRYNAAQEFKKFLLEN 622
S+R A +EF +++ EN
Sbjct: 166 SHRGKALKEFYRWMKEN 182
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,695,484
Number of Sequences: 369166
Number of extensions: 1475904
Number of successful extensions: 3747
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3617
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3713
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5927776870
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)