Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_O06
(488 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O15393|TMPS2_HUMAN Transmembrane protease, serine 2 prec... 55 9e-08
sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma pre... 53 4e-07
sp|P56677|ST14_MOUSE Suppressor of tumorigenicity 14 (Epithin) 53 4e-07
sp|P16295|FA9_CAVPO Coagulation factor IX (Christmas factor) 52 1e-06
sp|P19540|FA9_CANFA Coagulation factor IX precursor (Christ... 51 2e-06
sp|Q9Y5Y6|ST14_HUMAN Suppressor of tumorigenicity 14 (Matri... 51 2e-06
sp|P16293|FA9_PIG Coagulation factor IX (Christmas factor) ... 51 2e-06
sp|Q6SA95|FA9_FELCA Coagulation factor IX precursor (Christ... 50 2e-06
sp|P23578|ACRO_MOUSE Acrosin precursor [Contains: Acrosin l... 50 4e-06
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 50 4e-06
>sp|O15393|TMPS2_HUMAN Transmembrane protease, serine 2 precursor [Contains: Transmembrane
protease, serine 2 non-catalytic chain; Transmembrane
protease, serine 2 catalytic chain]
Length = 492
Score = 55.1 bits (131), Expect = 9e-08
Identities = 43/162 (26%), Positives = 64/162 (39%)
Frame = +1
Query: 1 LSTITLAFKTNAKIMKRVIGGEEAPPDKFRWAVSIKGDVDELKSSGACGASILKTKGNIS 180
L I N+ R++GGE A P + W VS+ +++ CG SI+ +
Sbjct: 239 LRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSL-----HVQNVHVCGGSIITPE---- 289
Query: 181 WLVTAAHCFYPSNKKKTFDLTKPELWHARVGLMKVDFIYNKHGRGFLTNNKLITFFSKAF 360
W+VTAAHC L P W A G+++ F++ +G G+
Sbjct: 290 WIVTAAHCVEK-------PLNNPWHWTAFAGILRQSFMF--YGAGY-------------- 326
Query: 361 RKLFQSKQNEVVTTGDIHIKNIIIHPYYKSNRLEYDIALMKL 486
++ +I HP Y S DIALMKL
Sbjct: 327 -----------------QVEKVISHPNYDSKTKNNDIALMKL 351
>sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 52.8 bits (125), Expect = 4e-07
Identities = 43/150 (28%), Positives = 65/150 (43%)
Frame = +1
Query: 37 KIMKRVIGGEEAPPDKFRWAVSIKGDVDELKSSGACGASILKTKGNISWLVTAAHCFYPS 216
KI R++GG + ++ W VS++ V + + CG SI+ + W++TAAHCF
Sbjct: 386 KINARIVGGTNSSLGEWPWQVSLQ--VKLVSQNHMCGGSIIGRQ----WILTAAHCF--- 436
Query: 217 NKKKTFDLTKPELWHARVGLMKVDFIYNKHGRGFLTNNKLITFFSKAFRKLFQSKQNEVV 396
+ P++W G++ + I NK T FS
Sbjct: 437 -----DGIPYPDVWRIYGGILNLSEITNK------------TPFSS-------------- 465
Query: 397 TTGDIHIKNIIIHPYYKSNRLEYDIALMKL 486
IK +IIH YK + YDIAL+KL
Sbjct: 466 ------IKELIIHQKYKMSEGSYDIALIKL 489
>sp|P56677|ST14_MOUSE Suppressor of tumorigenicity 14 (Epithin)
Length = 855
Score = 52.8 bits (125), Expect = 4e-07
Identities = 43/146 (29%), Positives = 61/146 (41%)
Frame = +1
Query: 49 RVIGGEEAPPDKFRWAVSIKGDVDELKSSGACGASILKTKGNISWLVTAAHCFYPSNKKK 228
RV+GG A ++ W VS+ L CGAS++ WLV+AAHCF K
Sbjct: 614 RVVGGTNADEGEWPWQVSLHA----LGQGHLCGASLISP----DWLVSAAHCFQDDKNFK 665
Query: 229 TFDLTKPELWHARVGLMKVDFIYNKHGRGFLTNNKLITFFSKAFRKLFQSKQNEVVTTGD 408
D T +W A +GL L QSK++ +
Sbjct: 666 YSDYT---MWTAFLGL------------------------------LDQSKRS-ASGVQE 691
Query: 409 IHIKNIIIHPYYKSNRLEYDIALMKL 486
+ +K II HP + +YDIAL++L
Sbjct: 692 LKLKRIITHPSFNDFTFDYDIALLEL 717
>sp|P16295|FA9_CAVPO Coagulation factor IX (Christmas factor)
Length = 285
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/148 (27%), Positives = 61/148 (41%), Gaps = 2/148 (1%)
Frame = +1
Query: 49 RVIGGEEAPPDKFRWAVSIKGDVDELKSSGACGASILKTKGNISWLVTAAHCFYPSNKKK 228
RV+GGE+A P +F W V + G+ + CG SI+ K W+VTAAHC P
Sbjct: 58 RVVGGEDAKPGQFPWQVLLNGETEAF-----CGGSIVNEK----WIVTAAHCILPG---- 104
Query: 229 TFDLTKPELWHARVGLMKVDFIYNKHGRGFLTNNKLITFFSKAFRKLFQSKQNEVVTTGD 408
+K++ + KH K ++Q VT
Sbjct: 105 ----------------IKIEVVAGKHN----------------IEKKEDTEQRRNVT--- 129
Query: 409 IHIKNIIIHPYYKS--NRLEYDIALMKL 486
II+H Y + N+ +DIAL++L
Sbjct: 130 ----QIILHHSYNASFNKYSHDIALLEL 153
>sp|P19540|FA9_CANFA Coagulation factor IX precursor (Christmas factor) [Contains:
Coagulation factor IXa light chain; Coagulation factor
IXa heavy chain]
Length = 452
Score = 50.8 bits (120), Expect = 2e-06
Identities = 26/58 (44%), Positives = 33/58 (56%)
Frame = +1
Query: 49 RVIGGEEAPPDKFRWAVSIKGDVDELKSSGACGASILKTKGNISWLVTAAHCFYPSNK 222
RV+GG++A P +F W V + G VD CG SI+ K W+VTAAHC P K
Sbjct: 217 RVVGGKDAKPGQFPWQVLLNGKVDAF-----CGGSIINEK----WVVTAAHCIEPDVK 265
>sp|Q9Y5Y6|ST14_HUMAN Suppressor of tumorigenicity 14 (Matriptase) (Membrane-type serine
protease 1) (MT-SP1) (Prostamin) (Serine protease
TADG-15) (Tumor associated differentially-expressed
gene-15 protein)
Length = 855
Score = 50.8 bits (120), Expect = 2e-06
Identities = 38/146 (26%), Positives = 58/146 (39%)
Frame = +1
Query: 49 RVIGGEEAPPDKFRWAVSIKGDVDELKSSGACGASILKTKGNISWLVTAAHCFYPSNKKK 228
RV+GG +A ++ W VS+ L CGAS++ +WLV+AAHC+ +
Sbjct: 614 RVVGGTDADEGEWPWQVSLHA----LGQGHICGASLISP----NWLVSAAHCYIDD---R 662
Query: 229 TFDLTKPELWHARVGLMKVDFIYNKHGRGFLTNNKLITFFSKAFRKLFQSKQNEVVTTGD 408
F + P W A +G L Q +
Sbjct: 663 GFRYSDPTQWTAFLG-------------------------------LHDQSQRSAPGVQE 691
Query: 409 IHIKNIIIHPYYKSNRLEYDIALMKL 486
+K II HP++ +YDIAL++L
Sbjct: 692 RRLKRIISHPFFNDFTFDYDIALLEL 717
>sp|P16293|FA9_PIG Coagulation factor IX (Christmas factor) [Contains: Coagulation
factor IXa light chain; Coagulation factor IXa heavy
chain]
Length = 409
Score = 50.8 bits (120), Expect = 2e-06
Identities = 25/58 (43%), Positives = 32/58 (55%)
Frame = +1
Query: 49 RVIGGEEAPPDKFRWAVSIKGDVDELKSSGACGASILKTKGNISWLVTAAHCFYPSNK 222
R++GGE A P +F W V + G +D CG SI+ K W+VTAAHC P K
Sbjct: 182 RIVGGENAKPGQFPWQVLLNGKIDAF-----CGGSIINEK----WVVTAAHCIEPGVK 230
>sp|Q6SA95|FA9_FELCA Coagulation factor IX precursor (Christmas factor) [Contains:
Coagulation factor IXa light chain; Coagulation factor
IXa heavy chain]
Length = 466
Score = 50.4 bits (119), Expect = 2e-06
Identities = 24/57 (42%), Positives = 33/57 (57%)
Frame = +1
Query: 43 MKRVIGGEEAPPDKFRWAVSIKGDVDELKSSGACGASILKTKGNISWLVTAAHCFYP 213
+ R++GG+ A P +F W V +KG +D CG SI+ K W+VTAAHC P
Sbjct: 229 LTRIVGGKTAKPGQFPWQVLLKGKIDAF-----CGGSIINEK----WVVTAAHCINP 276
>sp|P23578|ACRO_MOUSE Acrosin precursor [Contains: Acrosin light chain; Acrosin heavy
chain]
Length = 436
Score = 49.7 bits (117), Expect = 4e-06
Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 1/97 (1%)
Frame = +1
Query: 16 LAFKTNAKIMKRVIGGEEAPPDKFRWAVSIKGDVDE-LKSSGACGASILKTKGNISWLVT 192
L F+ N++ R++ G+ A + W VS++ + ACG S+L N W++T
Sbjct: 31 LRFRQNSQAGTRIVSGQSAQLGAWPWMVSLQIFTSHNSRRYHACGGSLL----NSHWVLT 86
Query: 193 AAHCFYPSNKKKTFDLTKPELWHARVGLMKVDFIYNK 303
AAHCF NKKK +D W G ++++ NK
Sbjct: 87 AAHCF--DNKKKVYD------WRLVFGAQEIEYGRNK 115
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 49.7 bits (117), Expect = 4e-06
Identities = 40/150 (26%), Positives = 62/150 (41%)
Frame = +1
Query: 37 KIMKRVIGGEEAPPDKFRWAVSIKGDVDELKSSGACGASILKTKGNISWLVTAAHCFYPS 216
KI R++GG A ++ W VS++ V + + CG SI+ + W++TAAHCF
Sbjct: 386 KINARIVGGTNASLGEWPWQVSLQ--VKLVSQTHLCGGSIIGRQ----WVLTAAHCF--- 436
Query: 217 NKKKTFDLTKPELWHARVGLMKVDFIYNKHGRGFLTNNKLITFFSKAFRKLFQSKQNEVV 396
+ P++W G++ + I +
Sbjct: 437 -----DGIPYPDVWRIYGGILSLSEITKE------------------------------- 460
Query: 397 TTGDIHIKNIIIHPYYKSNRLEYDIALMKL 486
T IK +IIH YK + YDIAL+KL
Sbjct: 461 -TPSSRIKELIIHQEYKVSEGNYDIALIKL 489
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,918,420
Number of Sequences: 369166
Number of extensions: 854703
Number of successful extensions: 2786
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2515
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2654
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 2970720600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)