Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_N13
(803 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P24298|ALAT_HUMAN Alanine aminotransferase (Glutamic--py... 227 3e-59
sp|P25409|ALAT_RAT Alanine aminotransferase (Glutamic--pyru... 221 1e-57
sp|Q8QZR5|ALAT_MOUSE Alanine aminotransferase (Glutamic--py... 221 2e-57
sp|P52894|ALA2_HORVU Alanine aminotransferase 2 (GPT) (Glut... 169 1e-41
sp|P34106|ALA2_PANMI Alanine aminotransferase 2 (GPT) (Glut... 166 7e-41
sp|P52892|ALAT_YEAST Putative alanine aminotransferase (Glu... 159 6e-39
sp|P52893|ALAM_YEAST Putative alanine aminotransferase, mit... 156 5e-38
sp|Q10334|ALAT_SCHPO Putative alanine aminotransferase (Glu... 142 8e-34
sp|P71348|Y286_HAEIN Probable aminotransferase HI0286 49 1e-05
sp|P63499|AAT_MYCBO Probable aspartate aminotransferase (Tr... 46 1e-04
>sp|P24298|ALAT_HUMAN Alanine aminotransferase (Glutamic--pyruvic transaminase) (GPT)
(Glutamic--alanine transaminase)
Length = 496
Score = 227 bits (578), Expect = 3e-59
Identities = 111/213 (52%), Positives = 148/213 (69%), Gaps = 1/213 (0%)
Frame = +1
Query: 163 LSIHNMNANIKNLEYAVRGPIVIKAQELEKRLAQGENLPFKEVIKCNIGDCHAMGQQPIT 342
L++ MN ++ +EYAVRGPIV +A ELE+ L QG PF EVI+ NIGD AMGQ+PIT
Sbjct: 21 LTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPFTEVIRANIGDAQAMGQRPIT 80
Query: 343 FLRQVVTLTAMPEFLKSKHFPQDAKNRAKRILESCGGESVGAYSQSTGVEVVRHDVAEFI 522
FLRQV+ L P+ L S +FP DAK RA+RIL++CGG S+GAYS S+G++++R DVA +I
Sbjct: 81 FLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHSLGAYSVSSGIQLIREDVARYI 140
Query: 523 SKRD-GIPSNPNDIFLSTGASEAIKVILQMMATQTHGKDKAGIMVPIPQYPLYSATNAEY 699
+RD GIP++PN++FLSTGAS+AI +L+++ G + G+++PIPQYPLYSAT AE
Sbjct: 141 ERRDGGIPADPNNVFLSTGASDAIVTVLKLLVA-GEGHTRTGVLIPIPQYPLYSATLAEL 199
Query: 700 NAYQIGYYLSEETNWGXXXXXXXXXXXXXXKHC 798
A Q+ YYL EE W HC
Sbjct: 200 GAVQVDYYLDEERAWALDVAELHRALGQARDHC 232
>sp|P25409|ALAT_RAT Alanine aminotransferase (Glutamic--pyruvic transaminase) (GPT)
(Glutamic--alanine transaminase)
Length = 496
Score = 221 bits (564), Expect = 1e-57
Identities = 108/195 (55%), Positives = 146/195 (74%), Gaps = 1/195 (0%)
Frame = +1
Query: 163 LSIHNMNANIKNLEYAVRGPIVIKAQELEKRLAQGENLPFKEVIKCNIGDCHAMGQQPIT 342
L++ MN ++ +EYAVRGPIV +A ELE+ L QG PF EVI+ NIGD AMGQ+PIT
Sbjct: 21 LTLDTMNPCVRRVEYAVRGPIVQRALELEQELRQGVKKPFTEVIRANIGDAQAMGQRPIT 80
Query: 343 FLRQVVTLTAMPEFLKSKHFPQDAKNRAKRILESCGGESVGAYSQSTGVEVVRHDVAEFI 522
F RQV+ L P L S FP+DAK RA+RIL++CGG S+GAYS S+G++ +R DVA++I
Sbjct: 81 FFRQVLALCVYPNLLSSPDFPEDAKRRAERILQACGGHSLGAYSISSGIQPIREDVAQYI 140
Query: 523 SKRD-GIPSNPNDIFLSTGASEAIKVILQMMATQTHGKDKAGIMVPIPQYPLYSATNAEY 699
+RD GIP++PN+IFLSTGAS+AI +L+++ + G+ + G+++PIPQYPLYSA AE
Sbjct: 141 ERRDGGIPADPNNIFLSTGASDAIVTMLKLLVS-GEGRARTGVLIPIPQYPLYSAALAEL 199
Query: 700 NAYQIGYYLSEETNW 744
+A Q+ YYL EE W
Sbjct: 200 DAVQVDYYLDEERAW 214
>sp|Q8QZR5|ALAT_MOUSE Alanine aminotransferase (Glutamic--pyruvic transaminase) (GPT)
(Glutamic--alanine transaminase)
Length = 496
Score = 221 bits (563), Expect = 2e-57
Identities = 108/195 (55%), Positives = 145/195 (74%), Gaps = 1/195 (0%)
Frame = +1
Query: 163 LSIHNMNANIKNLEYAVRGPIVIKAQELEKRLAQGENLPFKEVIKCNIGDCHAMGQQPIT 342
L++ MN ++ +EYAVRGPIV +A ELE+ L QG PF EVI+ NIGD AMGQ+PIT
Sbjct: 21 LTLDTMNPCVRRVEYAVRGPIVQRALELEQELRQGVKKPFTEVIRANIGDAQAMGQRPIT 80
Query: 343 FLRQVVTLTAMPEFLKSKHFPQDAKNRAKRILESCGGESVGAYSQSTGVEVVRHDVAEFI 522
F RQV+ L P L S FP+DAK RA+RIL++CGG S+GAYS S+G++ +R DVA++I
Sbjct: 81 FFRQVLALCVYPNLLSSPDFPEDAKRRAERILQACGGHSLGAYSISSGIQPIREDVAQYI 140
Query: 523 SKRD-GIPSNPNDIFLSTGASEAIKVILQMMATQTHGKDKAGIMVPIPQYPLYSATNAEY 699
+RD GIP++PN+IFLSTGAS+AI +L+++ G+ + G+++PIPQYPLYSA AE
Sbjct: 141 ERRDGGIPADPNNIFLSTGASDAIVTMLKLLVA-GEGRARTGVLIPIPQYPLYSAALAEL 199
Query: 700 NAYQIGYYLSEETNW 744
+A Q+ YYL EE W
Sbjct: 200 DAVQVDYYLDEERAW 214
>sp|P52894|ALA2_HORVU Alanine aminotransferase 2 (GPT) (Glutamic--pyruvic transaminase 2)
(Glutamic--alanine transaminase 2) (ALAAT-2)
Length = 482
Score = 169 bits (427), Expect = 1e-41
Identities = 87/201 (43%), Positives = 132/201 (65%), Gaps = 5/201 (2%)
Frame = +1
Query: 160 SLSIHNMNANIKNLEYAVRGPIVIKAQELEKRL-AQGENLPFKEVIKCNIGDCHAMGQQP 336
++++ N+N + EYAVRG IVI AQ L+++L Q +LPF E++ CNIG+ ++GQQP
Sbjct: 4 TVAVDNLNPKVLKCEYAVRGEIVIHAQRLQEQLKTQPGSLPFDEILYCNIGNPQSLGQQP 63
Query: 337 ITFLRQVVTLTAMPEFLKSKH----FPQDAKNRAKRILESCGGESVGAYSQSTGVEVVRH 504
+TF R+V+ L P+ L+ + F D+ +RAK+IL G + GAYS S G++ +R
Sbjct: 64 VTFFREVLALCDHPDLLQREEIKTLFSADSISRAKQILAMIPGRATGAYSHSQGIKGLRD 123
Query: 505 DVAEFISKRDGIPSNPNDIFLSTGASEAIKVILQMMATQTHGKDKAGIMVPIPQYPLYSA 684
+A I+ RDG P+N +DIFL+ GAS + +++Q++ +K GI+VPIPQYPLYSA
Sbjct: 124 AIASGIASRDGFPANADDIFLTDGASPGVHLMMQLLIR----NEKDGILVPIPQYPLYSA 179
Query: 685 TNAEYNAYQIGYYLSEETNWG 747
+ A + + YYL+E T WG
Sbjct: 180 SIALHGGALVPYYLNESTGWG 200
>sp|P34106|ALA2_PANMI Alanine aminotransferase 2 (GPT) (Glutamic--pyruvic transaminase 2)
(Glutamic--alanine transaminase 2) (ALAAT-2)
Length = 482
Score = 166 bits (420), Expect = 7e-41
Identities = 86/201 (42%), Positives = 131/201 (65%), Gaps = 5/201 (2%)
Frame = +1
Query: 160 SLSIHNMNANIKNLEYAVRGPIVIKAQELEKRL-AQGENLPFKEVIKCNIGDCHAMGQQP 336
++++ N+N + EYAVRG IVI AQ L+++L Q +LPF E++ CNIG+ ++GQQP
Sbjct: 4 TVAVENLNPKVLKCEYAVRGEIVIHAQHLQQQLQTQPGSLPFDEILYCNIGNPQSLGQQP 63
Query: 337 ITFLRQVVTLTAMPEFLKSKH----FPQDAKNRAKRILESCGGESVGAYSQSTGVEVVRH 504
+TF R+V+ L P L+ + F DA +RAK+IL + G + GAYS S G++ +R
Sbjct: 64 VTFFREVLALCDHPCLLEKEETKSLFSADAISRAKQILSTIPGRATGAYSHSQGIKGLRD 123
Query: 505 DVAEFISKRDGIPSNPNDIFLSTGASEAIKVILQMMATQTHGKDKAGIMVPIPQYPLYSA 684
+A I+ RDG P+N +DIF++ GAS + +++Q++ +K GI+ PIPQYPLYSA
Sbjct: 124 AIAAGIASRDGFPANADDIFVTDGASPGVHMMMQLLIR----NEKDGILCPIPQYPLYSA 179
Query: 685 TNAEYNAYQIGYYLSEETNWG 747
+ A + + YYL E+T WG
Sbjct: 180 SIALHGGTLVPYYLDEKTGWG 200
>sp|P52892|ALAT_YEAST Putative alanine aminotransferase (Glutamic--pyruvic transaminase)
(GPT) (Glutamic--alanine transaminase)
Length = 507
Score = 159 bits (403), Expect = 6e-39
Identities = 86/200 (43%), Positives = 127/200 (63%), Gaps = 10/200 (5%)
Frame = +1
Query: 175 NMNANIKNLEYAVRGPIVIKAQELEKRLAQG-ENLPFKEVIKCNIGDCHAMGQQPITFLR 351
++N + EYAVRG I +A EL++ L + E LPF ++I NIG+ + Q+P+TF R
Sbjct: 30 DLNTGVTKAEYAVRGAIPTRADELKEELKKNPEVLPFDDIINANIGNPQQLDQKPLTFTR 89
Query: 352 QVVTLTAMPEFLKSKH--------FPQDAKNRAKRILESCGGESVGAYSQSTGVEVVRHD 507
QV+ + PE L+ H F +DA RA+R+L GG S+GAYS S GV +R
Sbjct: 90 QVLAILEYPEILRVGHNELASLNLFSRDALERAERLLNDIGG-SIGAYSHSQGVPGIRQT 148
Query: 508 VAEFISKRDG-IPSNPNDIFLSTGASEAIKVILQMMATQTHGKDKAGIMVPIPQYPLYSA 684
VA+FI++RDG P+ P DI+L+TGAS A +L ++ + + G+++PIPQYPLY+A
Sbjct: 149 VADFITRRDGGEPATPEDIYLTTGASSAATSLLSLLCKDS----QTGLLIPIPQYPLYTA 204
Query: 685 TNAEYNAYQIGYYLSEETNW 744
+ + +NA + YYL EE+NW
Sbjct: 205 SASLFNAQVLPYYLDEESNW 224
>sp|P52893|ALAM_YEAST Putative alanine aminotransferase, mitochondrial precursor
(Glutamic--pyruvic transaminase) (GPT)
(Glutamic--alanine transaminase)
Length = 592
Score = 156 bits (395), Expect = 5e-38
Identities = 90/204 (44%), Positives = 128/204 (62%), Gaps = 10/204 (4%)
Frame = +1
Query: 163 LSIHNMNANIKNLEYAVRGPIVIKAQELEKRLAQG-ENLPFKEVIKCNIGDCHAMGQQPI 339
L++ ++N N+ +YAVRG I ++A+EL+ +L + ++LPF +I NIG+ + Q+P+
Sbjct: 111 LTLEDVNENVLKAKYAVRGAIPMRAEELKAQLEKDPQSLPFDRIINANIGNPQQLQQKPL 170
Query: 340 TFLRQVVTLTAMPEFLK--------SKHFPQDAKNRAKRILESCGGESVGAYSQSTGVEV 495
T+ RQV++L PE L SK F DA RAK ++E GG SVGAYS S GVE
Sbjct: 171 TYYRQVLSLLQYPELLNQNEQQLVDSKLFKLDAIKRAKSLMEDIGG-SVGAYSSSQGVEG 229
Query: 496 VRHDVAEFISKRD-GIPSNPNDIFLSTGASEAIKVILQMMATQTHGKDKAGIMVPIPQYP 672
+R VAEFI+KRD G S P DIFL+ GAS A+ +L + + G+++PIPQYP
Sbjct: 230 IRKSVAEFITKRDEGEISYPEDIFLTAGASAAVNYLLSIFCRGP----ETGVLIPIPQYP 285
Query: 673 LYSATNAEYNAYQIGYYLSEETNW 744
LY+AT A N+ + YYL E + W
Sbjct: 286 LYTATLALNNSQALPYYLDENSGW 309
>sp|Q10334|ALAT_SCHPO Putative alanine aminotransferase (Glutamic--pyruvic transaminase)
(GPT) (Glutamic--alanine transaminase)
Length = 505
Score = 142 bits (359), Expect = 8e-34
Identities = 79/200 (39%), Positives = 115/200 (57%), Gaps = 8/200 (4%)
Frame = +1
Query: 169 IHNMNANIKNLEYAVRGPIVIKAQELEKRLAQG-ENLPFKEVIKCNIGDCHAMGQQPITF 345
++++N + YAVRG + I A E++ L + + PF E++ NIG+ MGQ PITF
Sbjct: 30 LNSLNQQVFKANYAVRGALAILADEIQDDLLENPSSYPFSEIVYANIGNPQQMGQSPITF 89
Query: 346 LRQVVTLTAMPEFLKSKH-------FPQDAKNRAKRILESCGGESVGAYSQSTGVEVVRH 504
+RQV++L P L FP D R+K +L+ G S+GAYS S G+ +VR
Sbjct: 90 VRQVLSLCQYPTLLDHAEEKWFQNLFPTDVVQRSKMLLKESG--SLGAYSASQGIPLVRR 147
Query: 505 DVAEFISKRDGIPSNPNDIFLSTGASEAIKVILQMMATQTHGKDKAGIMVPIPQYPLYSA 684
VA+FI RDG P+DI+L++GAS A ++I+ ++ + G+MVP PQYPLY A
Sbjct: 148 HVADFIRARDGFDCEPSDIYLTSGASHAARLIMTLII----ARPTDGVMVPAPQYPLYGA 203
Query: 685 TNAEYNAYQIGYYLSEETNW 744
+ + Y LSEE NW
Sbjct: 204 QIDLMSGSMVSYSLSEENNW 223
>sp|P71348|Y286_HAEIN Probable aminotransferase HI0286
Length = 404
Score = 49.3 bits (116), Expect = 1e-05
Identities = 40/185 (21%), Positives = 74/185 (40%)
Frame = +1
Query: 190 IKNLEYAVRGPIVIKAQELEKRLAQGENLPFKEVIKCNIGDCHAMGQQPITFLRQVVTLT 369
++++ Y +RGP+ +A LE+ +++K NIG+ G +
Sbjct: 10 LEHVCYDIRGPVHKEALRLEEE--------GNKILKLNIGNPAPFGFEA----------- 50
Query: 370 AMPEFLKSKHFPQDAKNRAKRILESCGGESVGAYSQSTGVEVVRHDVAEFISKRDGIPSN 549
P + R L S G Y S G+ R + ++ + + +
Sbjct: 51 -----------PDEILVDVLRNLPSAQG-----YCDSKGLYSARKAIVQYYQSKGILGAT 94
Query: 550 PNDIFLSTGASEAIKVILQMMATQTHGKDKAGIMVPIPQYPLYSATNAEYNAYQIGYYLS 729
ND+++ G SE I + +Q + D ++VP+P YPL++A + Y
Sbjct: 95 VNDVYIGNGVSELITMAMQALLN-----DGDEVLVPMPDYPLWTAAVTLSGGKAVHYLCD 149
Query: 730 EETNW 744
E+ NW
Sbjct: 150 EDANW 154
>sp|P63499|AAT_MYCBO Probable aspartate aminotransferase (Transaminase A) (ASPAT)
sp|P63498|AAT_MYCTU Probable aspartate aminotransferase (Transaminase A) (ASPAT)
Length = 429
Score = 46.2 bits (108), Expect = 1e-04
Identities = 46/190 (24%), Positives = 77/190 (40%), Gaps = 2/190 (1%)
Frame = +1
Query: 181 NANIKNLEYAVRGPIVIKAQELEKRLAQGENLPFKEVIKCNIGDCHAMG-QQPITFLRQV 357
+A ++++ Y +RGP+ A LE A+G ++K NIG+ G + P +R +
Sbjct: 31 SAKLQDVLYEIRGPVHQHAARLE---AEGHR-----ILKLNIGNPAPFGFEAPDVIMRDI 82
Query: 358 VTLTAMPEFLKSKHFPQDAKNRAKRILESCGGESVGAYSQSTGVEVVRHDVAEFISKRDG 537
+ A+P YS S G+ R V G
Sbjct: 83 IQ--ALPY--------------------------AQGYSDSQGILSARRAVVTRYELVPG 114
Query: 538 IPS-NPNDIFLSTGASEAIKVILQMMATQTHGKDKAGIMVPIPQYPLYSATNAEYNAYQI 714
P + +D++L G SE I + LQ A +G +++P P YPL++A+ + +
Sbjct: 115 FPRFDVDDVYLGNGVSELITMTLQ--ALLDNGDQ---VLIPSPDYPLWTASTSLAGGTPV 169
Query: 715 GYYLSEETNW 744
Y E W
Sbjct: 170 HYLCDETQGW 179
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,798,669
Number of Sequences: 369166
Number of extensions: 1556915
Number of successful extensions: 3834
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3709
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3811
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)