Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_M04
(823 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P50580|PA2G4_MOUSE Proliferation-associated protein 2G4 ... 213 5e-55
sp|Q9UQ80|PA2G4_HUMAN Proliferation-associated protein 2G4 ... 210 4e-54
sp|Q09184|CDB4_SCHPO Curved DNA-binding protein (42 kDa pro... 159 9e-39
sp|O28438|AMPM_ARCFU Methionine aminopeptidase (MAP) (Pepti... 70 9e-12
sp|Q9UYT4|AMPM_PYRAB Methionine aminopeptidase (MAP) (Pepti... 60 7e-09
sp|O58362|AMPM_PYRHO Methionine aminopeptidase (MAP) (Pepti... 56 1e-07
sp|O08663|AMPM2_MOUSE Methionine aminopeptidase 2 (MetAP 2)... 52 2e-06
sp|P50579|AMPM2_HUMAN Methionine aminopeptidase 2 (MetAP 2)... 52 3e-06
sp|P56218|AMPM_PYRFU Methionine aminopeptidase (MAP) (Pepti... 52 3e-06
sp|P22624|AMPM_METFE Probable methionine aminopeptidase (MA... 51 3e-06
>sp|P50580|PA2G4_MOUSE Proliferation-associated protein 2G4 (Proliferation-associated
protein 1) (Protein p38-2G4)
Length = 394
Score = 213 bits (542), Expect = 5e-55
Identities = 110/267 (41%), Positives = 167/267 (62%), Gaps = 3/267 (1%)
Frame = +1
Query: 25 EAELEVNNLEDETIVNKYKMAADIVQRILKELITKCQPGANLLELCTYGDQXXXXXXXXX 204
E E + + ++ +V KYKM DI R+L+ L+ G ++L LC GD
Sbjct: 4 EDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKI 63
Query: 205 XXXXXXXXXGCAYPTSISKNNIVANFCPEQSNETF--ENGDLVKIDLGCYIDGYAAVVGH 378
G A+PTSIS NN V +F P +S++ + + GDLVKIDLG ++DG+ A V H
Sbjct: 64 FKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAH 123
Query: 379 TFVIGASKDNKVTGRKADVILAAHNCVEAALRLFKPGKDSKGVTEPLIHVAGDYNCKVLE 558
TFVIG ++ +VTGRKADVI AAH C EAALRL KPG + VTE VA +NC +E
Sbjct: 124 TFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIE 183
Query: 559 NCMANGMEKNIFENDKTFMINPSDDLKKS-EKVDFDVNQVWTIDVVVTTGDAKVKEREVK 735
+++ +++++ + +KT + NP+D KK EK +F+V++V+ +DV+V++G+ K K+ +
Sbjct: 184 GMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQR 243
Query: 736 STVYRRILADKKYQLKLKASRQIYSDV 816
+T+Y+R K+Y LK+K SR +S+V
Sbjct: 244 TTIYKRD-PSKQYGLKMKTSRAFFSEV 269
>sp|Q9UQ80|PA2G4_HUMAN Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4
homolog) (hG4-1)
Length = 394
Score = 210 bits (534), Expect = 4e-54
Identities = 108/267 (40%), Positives = 166/267 (62%), Gaps = 3/267 (1%)
Frame = +1
Query: 25 EAELEVNNLEDETIVNKYKMAADIVQRILKELITKCQPGANLLELCTYGDQXXXXXXXXX 204
E E + + ++ +V KYKM DI R+L+ L+ G ++L LC GD
Sbjct: 4 EDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKI 63
Query: 205 XXXXXXXXXGCAYPTSISKNNIVANFCPEQSNETF--ENGDLVKIDLGCYIDGYAAVVGH 378
G A+PTSIS NN V +F P +S++ + + GDLVKIDLG ++DG+ A V H
Sbjct: 64 FKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAH 123
Query: 379 TFVIGASKDNKVTGRKADVILAAHNCVEAALRLFKPGKDSKGVTEPLIHVAGDYNCKVLE 558
TFV+ ++ +VTGRKADVI AAH C EAALRL KPG + VTE VA +NC +E
Sbjct: 124 TFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIE 183
Query: 559 NCMANGMEKNIFENDKTFMINPSDDLKKS-EKVDFDVNQVWTIDVVVTTGDAKVKEREVK 735
+++ +++++ + +KT + NP+D KK EK +F+V++V+ +DV+V++G+ K K+ +
Sbjct: 184 GMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQR 243
Query: 736 STVYRRILADKKYQLKLKASRQIYSDV 816
+T+Y+R K+Y LK+K SR +S+V
Sbjct: 244 TTIYKRD-PSKQYGLKMKTSRAFFSEV 269
>sp|Q09184|CDB4_SCHPO Curved DNA-binding protein (42 kDa protein)
Length = 381
Score = 159 bits (402), Expect = 9e-39
Identities = 91/276 (32%), Positives = 159/276 (57%), Gaps = 6/276 (2%)
Frame = +1
Query: 7 TMSSDSEAELEVNNLEDETIVNKYKMAADIVQRILKELITKCQPGANLLELCTYGDQXXX 186
T + SE ++ + ET VNKYK+A ++ Q ++K+++ CQPGA + ++C GD+
Sbjct: 3 TKEATSETAVDYSLSNPET-VNKYKIAGEVSQNVIKKVVELCQPGAKIYDICVRGDELLN 61
Query: 187 XXXXXXXXXXXXXXXGCAYPTSISKNNIVANFCPEQS----NETFENGDLVKIDLGCYID 354
G A+PT++S N++ A+ P +S N ++GD+VKI LG +ID
Sbjct: 62 EAIKKVYRTKDAYK-GIAFPTAVSPNDMAAHLSPLKSDPEANLALKSGDVVKILLGAHID 120
Query: 355 GYAAVVGHTFVIGASKDNKVTGRKADVILAAHNCVEAALRLFKPGKDSKGVTEPLIHVAG 534
G+A++V T V+ + VTG ADVI AA ++AA R KPG + VT+ + +A
Sbjct: 121 GFASLVATTTVVS---EEPVTGPAADVIAAASAALKAAQRTIKPGNTNWQVTDIVDKIAT 177
Query: 535 DYNCKVLENCMANGMEKNIFENDKTFMINPSDDLK-KSEKVDFDVNQVWTIDVVVTTG-D 708
Y CK + +++ E+ + + K ++NPSD + + + F+ +V+ +D++V+T
Sbjct: 178 SYGCKPVAGMLSHQQEREVIDGKKQVILNPSDSQRSEMDTFTFEEGEVYGVDILVSTSPS 237
Query: 709 AKVKEREVKSTVYRRILADKKYQLKLKASRQIYSDV 816
KVK ++ + +Y++ D Y LKL+ASR++YS++
Sbjct: 238 GKVKRSDIATRIYKK--TDTTYMLKLQASRKVYSEI 271
>sp|O28438|AMPM_ARCFU Methionine aminopeptidase (MAP) (Peptidase M)
Length = 291
Score = 69.7 bits (169), Expect = 9e-12
Identities = 66/259 (25%), Positives = 117/259 (45%), Gaps = 5/259 (1%)
Frame = +1
Query: 55 DETIVNKYKMAADIVQRILKELITKCQPGANLLELCTYGDQXXXXXXXXXXXXXXXXXXG 234
D+ + K A I+++ + E K PG +LE+ + +
Sbjct: 2 DDEVREKLIEAGKILKQAVNEAAEKIAPGVKILEVAEFVENRIIELGAKP---------- 51
Query: 235 CAYPTSISKNNIVANFCPEQSNE-TFENGDLVKIDLGCYIDGYAAVVGHTFVIGASKDNK 411
A+P +IS N+ A+F P++++E TF+ GD+VK+D+G +IDGY A + T +G DN
Sbjct: 52 -AFPANISINSDAAHFTPKKNDERTFKEGDVVKLDVGAHIDGYIADMAVTVDLG---DN- 106
Query: 412 VTGRKADVILAAHNCVEAALRLFKPGKDSKGVTEPLIHVAGDYNCKVLENCMANGMEKNI 591
+++ AA +EAA+ + + G + + + +Y K + N +G+ +
Sbjct: 107 -----TELVKAAKEALEAAMEVVRAGVSVSEIGKAIEDAITNYGFKPIVNLTGHGLLPYL 161
Query: 592 FENDKTFMINPSDDLKKSEK-VDFDVNQVWTIDVVVTTGDAKVKER---EVKSTVYRRIL 759
PS +EK V + V I+ T G KV ER E+ S + R
Sbjct: 162 NH------APPSIYNYATEKGVTLEEGMVVAIEPFATNGVGKVGERGECEIYSLLNPR-- 213
Query: 760 ADKKYQLKLKASRQIYSDV 816
+++K +R+I +V
Sbjct: 214 -----PVRMKMAREILKEV 227
>sp|Q9UYT4|AMPM_PYRAB Methionine aminopeptidase (MAP) (Peptidase M)
Length = 295
Score = 60.1 bits (144), Expect = 7e-09
Identities = 54/222 (24%), Positives = 96/222 (43%), Gaps = 3/222 (1%)
Frame = +1
Query: 67 VNKYKMAADIVQRILKELITKCQPGANLLELCTYGDQXXXXXXXXXXXXXXXXXXGCAYP 246
V+K A I +++ +E + +PG +LLEL + A+P
Sbjct: 3 VDKLIEAGKIAKKVREEAVKLAKPGVSLLELAEKIEGRIIELGAKP-----------AFP 51
Query: 247 TSISKNNIVANFCPEQSNET-FENGDLVKIDLGCYIDGYAAVVGHTFVIGASKDNKVTGR 423
++S N I A++ P + +ET + GD +KID+G +IDGY A T +G +D
Sbjct: 52 VNLSLNEIAAHYTPYKGDETTLKEGDYLKIDIGVHIDGYIADTAVTVRVGMEED------ 105
Query: 424 KADVILAAHNCVEAALRLFKPGKDSKGVTEPLIHVAGDYNCKVLENCMANGMEKNIFEND 603
D++ AA +E+A+ + + G + K + + + N + +E+
Sbjct: 106 --DLMEAAREALESAISVARAGVEIKELGRAIEDEIRKRGFNPIVNLSGHKIERYKLHAG 163
Query: 604 KTF--MINPSDDLKKSEKVDFDVNQVWTIDVVVTTGDAKVKE 723
+ + P D+ K E V+ I+ TTG +V E
Sbjct: 164 ISIPNIYRPHDNYKLRE------GDVFAIEPFATTGAGQVIE 199
>sp|O58362|AMPM_PYRHO Methionine aminopeptidase (MAP) (Peptidase M)
Length = 295
Score = 56.2 bits (134), Expect = 1e-07
Identities = 39/146 (26%), Positives = 70/146 (47%), Gaps = 1/146 (0%)
Frame = +1
Query: 67 VNKYKMAADIVQRILKELITKCQPGANLLELCTYGDQXXXXXXXXXXXXXXXXXXGCAYP 246
V+K A I +++ +E + +PG +LLEL + A+P
Sbjct: 3 VDKLIEAGKIAKKVREEAVKLAKPGVSLLELAEKIESRIVELGGKP-----------AFP 51
Query: 247 TSISKNNIVANFCPEQSNET-FENGDLVKIDLGCYIDGYAAVVGHTFVIGASKDNKVTGR 423
++S N + A++ P + ++T + GD +KIDLG +IDGY A T +G D
Sbjct: 52 ANLSLNEVAAHYTPYKGDQTVLKEGDYLKIDLGVHIDGYIADTAVTVRVGMDFD------ 105
Query: 424 KADVILAAHNCVEAALRLFKPGKDSK 501
+++ AA +E+A+ + + G + K
Sbjct: 106 --ELMEAAKEALESAISVARAGVEVK 129
>sp|O08663|AMPM2_MOUSE Methionine aminopeptidase 2 (MetAP 2) (Peptidase M 2) (Initiation
factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2)
Length = 478
Score = 52.0 bits (123), Expect = 2e-06
Identities = 52/225 (23%), Positives = 88/225 (39%), Gaps = 3/225 (1%)
Frame = +1
Query: 58 ETIVNKYKMAADIVQRILKELITKCQPGANLLELCTYGDQXXXXXXXXXXXXXXXXXXGC 237
E I N ++ AA+ +++ K +++ +PG ++E+C G
Sbjct: 163 EEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEIC-----EKLEDCSRKLIKENGLNAGL 217
Query: 238 AYPTSISKNNIVANFCPEQSNET-FENGDLVKIDLGCYIDGYAAVVGHTFVIGASKDNKV 414
A+PT S NN A++ P + T + D+ KID G +I G T D +
Sbjct: 218 AFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILL 277
Query: 415 TGRKADVILAAHNCVEAALRLFKPGKDSKGVTEPL-IHVAG-DYNCKVLENCMANGMEKN 588
T K D C +RL G+ + V E + + G Y K + N + +
Sbjct: 278 TAVK-DATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPY 336
Query: 589 IFENDKTFMINPSDDLKKSEKVDFDVNQVWTIDVVVTTGDAKVKE 723
KT I +K E + +V+ I+ +TG V +
Sbjct: 337 RIHAGKTVPI-----VKGGEATRMEEGEVYAIETFGSTGKGVVHD 376
>sp|P50579|AMPM2_HUMAN Methionine aminopeptidase 2 (MetAP 2) (Peptidase M 2) (Initiation
factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2)
Length = 478
Score = 51.6 bits (122), Expect = 3e-06
Identities = 51/225 (22%), Positives = 88/225 (39%), Gaps = 3/225 (1%)
Frame = +1
Query: 58 ETIVNKYKMAADIVQRILKELITKCQPGANLLELCTYGDQXXXXXXXXXXXXXXXXXXGC 237
E I N ++ AA+ +++ K +++ +PG ++E+C G
Sbjct: 163 EEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEIC-----EKLEDCSRKLIKENGLNAGL 217
Query: 238 AYPTSISKNNIVANFCPEQSNET-FENGDLVKIDLGCYIDGYAAVVGHTFVIGASKDNKV 414
A+PT S NN A++ P + T + D+ KID G +I G T D +
Sbjct: 218 AFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLL 277
Query: 415 TGRKADVILAAHNCVEAALRLFKPGKDSKGVTEPL-IHVAG-DYNCKVLENCMANGMEKN 588
K D C +RL G+ + V E + + G Y K + N + + +
Sbjct: 278 KAVK-DATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQY 336
Query: 589 IFENDKTFMINPSDDLKKSEKVDFDVNQVWTIDVVVTTGDAKVKE 723
KT I +K E + +V+ I+ +TG V +
Sbjct: 337 RIHAGKTVPI-----VKGGEATRMEEGEVYAIETFGSTGKGVVHD 376
>sp|P56218|AMPM_PYRFU Methionine aminopeptidase (MAP) (Peptidase M)
Length = 295
Score = 51.6 bits (122), Expect = 3e-06
Identities = 40/160 (25%), Positives = 76/160 (47%), Gaps = 6/160 (3%)
Frame = +1
Query: 73 KYKMAADIVQRILKELITKCQPGANLLELCTYGDQXXXXXXXXXXXXXXXXXXGCAYPTS 252
K A +I +++ ++ I +PG LLEL ++ A+P +
Sbjct: 5 KLMKAGEIAKKVREKAIKLARPGMLLLELAESIEKMIMELGGKP-----------AFPVN 53
Query: 253 ISKNNIVANFCPEQSNET-FENGDLVKIDLGCYIDGYAAVVGHTFVIGASKDNKVTGRKA 429
+S N I A++ P + + T + GD +KID+G +IDG+ A T +G +D + K
Sbjct: 54 LSINEIAAHYTPYKGDTTVLKEGDYLKIDVGVHIDGFIADTAVTVRVGMEEDELMEAAK- 112
Query: 430 DVILAAHNCVEAALRLFKPGKD-----SKGVTEPLIHVAG 534
+ + AA + A + + + GK K +P+++++G
Sbjct: 113 EALNAAISVARAGVEIKELGKAIENEIRKRGFKPIVNLSG 152
>sp|P22624|AMPM_METFE Probable methionine aminopeptidase (MAP) (Peptidase M)
Length = 188
Score = 51.2 bits (121), Expect = 3e-06
Identities = 37/179 (20%), Positives = 80/179 (44%), Gaps = 6/179 (3%)
Frame = +1
Query: 67 VNKYKMAADIVQRILKELITKCQPGANLLELCTYGDQXXXXXXXXXXXXXXXXXXGCAYP 246
+ K+K A I ++ K+ I + +L+L + + A+P
Sbjct: 1 MEKFKKAGKIASKVRKKAIKAVKGEMKILDLAEFIENEIEKMGAKP-----------AFP 49
Query: 247 TSISKNNIVANFCPEQSNET-FENGDLVKIDLGCYIDGYAAVVGHTFVIGASKD-----N 408
+IS N I A++ P +++ GDLVKID+G ++DG+ T ++ +D +
Sbjct: 50 CNISVNEITAHYSPPCNDDRKILPGDLVKIDIGVHVDGFIGDTATTVLVEGYEDLKNYND 109
Query: 409 KVTGRKADVILAAHNCVEAALRLFKPGKDSKGVTEPLIHVAGDYNCKVLENCMANGMEK 585
++ + +I AA + +E A+ + G + + E + + + K + N + +++
Sbjct: 110 ELAEKNKKMIEAAESALENAINTIRDGVEIGKIGEVIENTINKFGFKPISNLTGHTIDR 168
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.316 0.133 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,666,256
Number of Sequences: 369166
Number of extensions: 1274827
Number of successful extensions: 3896
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3764
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3872
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7907893860
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)