Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_M01
(569 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 190 2e-48
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 190 2e-48
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 186 4e-47
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 185 6e-47
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 181 1e-45
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 181 1e-45
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 179 3e-45
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 179 3e-45
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 176 4e-44
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 176 4e-44
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 190 bits (482), Expect = 2e-48
Identities = 94/165 (56%), Positives = 109/165 (66%), Gaps = 2/165 (1%)
Frame = +3
Query: 12 VDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFT 188
VDCS LMDNAFRYIKD G I++E YPY D +C N + I TGF
Sbjct: 175 VDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFV 234
Query: 189 DIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT 368
DI +E + AVAT+GPVSVAIDA H SFQLY G+YNE C LDHGVL VGYGT
Sbjct: 235 DIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGT 294
Query: 369 -QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
+ G YW+VKNSW TWGE GYIKM++++ NQCGIAT +SYP V
Sbjct: 295 DESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 190 bits (482), Expect = 2e-48
Identities = 93/165 (56%), Positives = 111/165 (67%), Gaps = 2/165 (1%)
Frame = +3
Query: 12 VDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFT 188
VDCS LMDNAFRYIKD G I++E YPY A D +C N + GFT
Sbjct: 177 VDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFT 236
Query: 189 DIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT 368
DI +E +A AVATVGPVSVAIDA H SFQ Y G+YNE C LDHGVL VG+GT
Sbjct: 237 DIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGT 296
Query: 369 -QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
+ G+ YW+VKNSW TWG+ G+IKM ++K+NQCGIA+ +SYPLV
Sbjct: 297 DESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 186 bits (472), Expect = 4e-47
Identities = 86/164 (52%), Positives = 116/164 (70%), Gaps = 1/164 (0%)
Frame = +3
Query: 12 VDCSXXXXXXXXXXXLMDNAFRYIK-DQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFT 188
VDCS M++AF YIK + GI++E YPY A DG+C+ + + + C+G T
Sbjct: 160 VDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHT 219
Query: 189 DIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT 368
+I S +ET L AV +GP+SV IDA H+SFQ Y SG+Y E SCS + LDH VLAVGYG+
Sbjct: 220 NIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGS 279
Query: 369 QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
+ G+ +W+VKNSW +WG++GYIKMS+++ N CGIAT+ASYPLV
Sbjct: 280 EGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 185 bits (470), Expect = 6e-47
Identities = 95/165 (57%), Positives = 109/165 (66%), Gaps = 2/165 (1%)
Frame = +3
Query: 12 VDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFT 188
VD S LMDNAF+YIK+ G ++SE YPY ATD +C P K TGF
Sbjct: 54 VDSSRPQGNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFV 113
Query: 189 DIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT 368
DI Q E L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG
Sbjct: 114 DIP-QREKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGF 172
Query: 369 Q-IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
+ K+WIVKNSW WG GY+KM+KD+ N CGIAT ASYP V
Sbjct: 173 EGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 181 bits (459), Expect = 1e-45
Identities = 92/168 (54%), Positives = 109/168 (64%), Gaps = 5/168 (2%)
Frame = +3
Query: 12 VDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFT 188
VDCS LMD AF+Y++D G ++SE YPY AT+ +CK NP V TGF
Sbjct: 167 VDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFV 226
Query: 189 DIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT 368
DI Q E L AVATVGP+SVAIDAGH SF YK GIY E CS+ +DHGVL VGYG
Sbjct: 227 DIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGF 285
Query: 369 QI----GKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
+ KYW+VKNSW WG GY+KM+KD++N CGIA+ ASYP V
Sbjct: 286 ESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 181 bits (458), Expect = 1e-45
Identities = 96/169 (56%), Positives = 108/169 (63%), Gaps = 6/169 (3%)
Frame = +3
Query: 12 VDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATD-GTCKRNPSKIVTKCTGF 185
VDCS LMDNAF+YIKD G ++SE YPY ATD +C P TGF
Sbjct: 167 VDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGF 226
Query: 186 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG 365
DI Q E L AVATVGP+SVAIDAGH SFQ YKSGIY + CS LDHGVL VGYG
Sbjct: 227 VDIP-QREKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYG 285
Query: 366 TQ----IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
+ K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 286 FEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 179 bits (455), Expect = 3e-45
Identities = 90/168 (53%), Positives = 105/168 (62%), Gaps = 5/168 (2%)
Frame = +3
Query: 12 VDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFT 188
VDCS M AF+Y+K+ G ++SE YPY A D CK P V TGFT
Sbjct: 167 VDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFT 226
Query: 189 DIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG- 365
+ E L AVATVGP+SVA+DAGH+SFQ YKSGIY E CS+ LDHGVL VGYG
Sbjct: 227 VVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGF 286
Query: 366 ---TQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
KYW+VKNSW WG +GY+K++KDK N CGIAT ASYP V
Sbjct: 287 EGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 179 bits (455), Expect = 3e-45
Identities = 94/168 (55%), Positives = 107/168 (63%), Gaps = 5/168 (2%)
Frame = +3
Query: 12 VDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDG-TCKRNPSKIVTKCTGF 185
VDCS LMDNAFRY+KD G ++SE YPY D TC P TGF
Sbjct: 167 VDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGF 226
Query: 186 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY- 362
D+ Q E L AVAT+GP+SVAIDAGH SFQ YKSGIY + CS+ LDHGVL VGY
Sbjct: 227 VDLP-QREKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYG 285
Query: 363 --GTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
GT K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 286 FEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 176 bits (446), Expect = 4e-44
Identities = 93/168 (55%), Positives = 108/168 (64%), Gaps = 5/168 (2%)
Frame = +3
Query: 12 VDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFT 188
VDCS LMD AF+YIK+ G ++SE YPY A DG+CK V TGF
Sbjct: 167 VDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFV 226
Query: 189 DIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY-- 362
DI Q E L AVATVGP+SVA+DA H S Q Y SGIY E +CS+ LDHGVL VGY
Sbjct: 227 DIPQQ-EKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGY 285
Query: 363 -GTQIGK-KYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
GT K KYW+VKNSW WG GYIK++KD+ N CG+AT ASYP+V
Sbjct: 286 EGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 176 bits (446), Expect = 4e-44
Identities = 87/164 (53%), Positives = 110/164 (67%), Gaps = 1/164 (0%)
Frame = +3
Query: 12 VDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFT 188
VDCS M +AF YIKD G I++E YPY A D +C+ + + I CTG
Sbjct: 159 VDCSTDYGNDGCGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSV 218
Query: 189 DIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT 368
++Q E L AV+ VGP+SVAIDA H SFQ Y SG+Y E++CS T LDHGVLAVGYGT
Sbjct: 219 EVQHTEEA-LQEAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGT 277
Query: 369 QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
+ K YW+VKNSW +WG++GYIKMS+++ N CGIA+ SYP V
Sbjct: 278 ESTKDYWLVKNSWGSSWGDAGYIKMSRNRDNNCGIASEPSYPTV 321
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,249,879
Number of Sequences: 369166
Number of extensions: 1251836
Number of successful extensions: 3823
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3441
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3517
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4177115900
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)