Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_K24
(871 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9SMH3|DYH1A_CHLRE Dynein 1-alpha heavy chain, flagellar... 222 1e-57
sp|Q9NYC9|DYH9_HUMAN Ciliary dynein heavy chain 9 (Axonemal... 125 1e-28
sp|Q39610|DYHA_CHLRE Dynein alpha chain, flagellar outer ar... 121 3e-27
sp|P23098|DYHC_TRIGR Dynein beta chain, ciliary 121 3e-27
sp|P39057|DYHC_ANTCR Dynein beta chain, ciliary 120 6e-27
sp|Q39565|DYHB_CHLRE Dynein beta chain, flagellar outer arm 118 2e-26
sp|Q96DT5|DYH11_HUMAN Ciliary dynein heavy chain 11 (Axonem... 115 2e-25
sp|Q9MBF8|DYH1B_CHLRE Dynein 1-beta heavy chain, flagellar ... 104 3e-22
sp|Q8TE73|DYH5_HUMAN Ciliary dynein heavy chain 5 (Axonemal... 104 3e-22
sp|Q8VHE6|DYH5_MOUSE Ciliary dynein heavy chain 5 (Axonemal... 103 6e-22
>sp|Q9SMH3|DYH1A_CHLRE Dynein 1-alpha heavy chain, flagellar inner arm I1 complex (1-alpha
DHC) (Dynein 1, subspecies f)
Length = 4625
Score = 222 bits (565), Expect = 1e-57
Identities = 112/231 (48%), Positives = 150/231 (64%)
Frame = -2
Query: 828 LLKKMFTSLTILKKALVGEAGMSNELDDINRSLANGMLPNCWRILAPETMKMLGSWLEHL 649
+L M +SL L++AL GE G S+ L+++ SL NG LP W L P T K LG+W+
Sbjct: 4398 VLGVMVSSLRDLQRALSGEIGFSSRLEELASSLYNGKLPAMWARLNPATEKALGAWMLWF 4457
Query: 648 QQRRRQYEAWIEAGKIDLPIIWLSGLHLPESYLTALIQKACRRNNWALDACTLATIVTKV 469
+R RQY+ W E G + +IWLSGLH+PE+Y+ AL+Q ACR W LD TL T VTK
Sbjct: 4458 GRRYRQYKDWTEHG--EPKVIWLSGLHIPETYIAALVQAACRDKGWPLDKSTLYTKVTK- 4514
Query: 468 DIRSSETLTMTPEFGCYAVGFYLEGCGWNVEKGCVQPQKSRELIQSMPVIQLHPIESHKY 289
++ P++GCY G YLEG W++E ++ Q + L+ +P++Q+ PIE++K
Sbjct: 4515 -FTDPYQVSERPKYGCYMSGLYLEGAAWDLEASQLRKQDPKVLVNELPILQVIPIEANKL 4573
Query: 288 KTTNTIQVPVYVTSQRRNAMGIGLVTVLDLATTEHSSHWVLQGIALALNSD 136
K NT + PVYVT RRNAMG+GLV DLA+ EHSSHWVLQG+AL LN D
Sbjct: 4574 KLANTFRAPVYVTQARRNAMGVGLVFDADLASAEHSSHWVLQGVALVLNID 4624
>sp|Q9NYC9|DYH9_HUMAN Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9)
Length = 4486
Score = 125 bits (315), Expect = 1e-28
Identities = 75/230 (32%), Positives = 117/230 (50%), Gaps = 1/230 (0%)
Frame = -2
Query: 831 LLLKKMFTSLTILKKALVGEAGMSNELDDINRSLANGMLPNCWRILAPETMKMLGSWLEH 652
+L +++ SL L+ L GE M++ ++++ +L M+P W A + L +W
Sbjct: 4264 ILTREIQRSLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPD 4323
Query: 651 LQQRRRQYEAWIEAGKIDLP-IIWLSGLHLPESYLTALIQKACRRNNWALDACTLATIVT 475
L R ++ EAW G +P +WL+G P+S+LTA++Q R+N W LD L +T
Sbjct: 4324 LLNRIKELEAW--TGDFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPLDQIALQCDMT 4381
Query: 474 KVDIRSSETLTMTPEFGCYAVGFYLEGCGWNVEKGCVQPQKSRELIQSMPVIQLHPIESH 295
K ++ E P G Y G ++EG W+ + G + K ++L MPV+ + I +
Sbjct: 4382 K---KNREEFRSPpreGAYIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPAD 4438
Query: 294 KYKTTNTIQVPVYVTSQRRNAMGIGLVTVLDLATTEHSSHWVLQGIALAL 145
K + PVY TSQR G V +L T E+ S WVL G+AL L
Sbjct: 4439 KQDCRSVYSCPVYKTSQR----GPTYVWTFNLKTKENPSKWVLAGVALLL 4484
>sp|Q39610|DYHA_CHLRE Dynein alpha chain, flagellar outer arm (DHC alpha)
Length = 4499
Score = 121 bits (303), Expect = 3e-27
Identities = 72/234 (30%), Positives = 114/234 (48%), Gaps = 3/234 (1%)
Frame = -2
Query: 828 LLKKMFTSLTILKKALVGEAGMSNELDDINRSLANGMLPNCWRILAPETMK---MLGSWL 658
LL +M S+ L+ L G MS+ ++ + + +A+ +P W ++ L +W
Sbjct: 4266 LLSEMKRSMEELQLGLDGALNMSDNMEKLAKGIASNTVPELWMSCMSTRVQEVYTLTAWY 4325
Query: 657 EHLQQRRRQYEAWIEAGKIDLPIIWLSGLHLPESYLTALIQKACRRNNWALDACTLATIV 478
+ + +R Q AW I +WL GL P+++LTA++Q R N LD T V
Sbjct: 4326 QDVVKRHDQLSAWTAGDIITPHSVWLPGLFNPKAFLTAVMQTFARANKLPLDVMKFMTEV 4385
Query: 477 TKVDIRSSETLTMTPEFGCYAVGFYLEGCGWNVEKGCVQPQKSRELIQSMPVIQLHPIES 298
T++ S E +T G Y G LEG W+ E GC++ K EL +MPV+Q+ P+ +
Sbjct: 4386 TRMT--SPEQVTEAAPLGVYVHGLVLEGARWDREDGCLRDSKPNELHPAMPVLQVKPVTA 4443
Query: 297 HKYKTTNTIQVPVYVTSQRRNAMGIGLVTVLDLATTEHSSHWVLQGIALALNSD 136
++ + PVY QR N +V+ L T + + WVL +AL L D
Sbjct: 4444 DQFNLEGYYECPVYTNMQRANVYS-PVVSTFTLRTQDMPAKWVLASVALLLQDD 4496
>sp|P23098|DYHC_TRIGR Dynein beta chain, ciliary
Length = 4466
Score = 121 bits (303), Expect = 3e-27
Identities = 74/230 (32%), Positives = 115/230 (50%), Gaps = 1/230 (0%)
Frame = -2
Query: 831 LLLKKMFTSLTILKKALVGEAGMSNELDDINRSLANGMLPNCWRILAPETMKMLGSWLEH 652
+L ++ SL L L GE ++ +++D++ +L +P W A ++ L SW
Sbjct: 4244 MLTSEIRRSLKELDLGLKGELTITPDMEDLSNALFLDQIPATWVKRAYPSLFGLTSWYAD 4303
Query: 651 LQQRRRQYEAWIEAGKIDLP-IIWLSGLHLPESYLTALIQKACRRNNWALDACTLATIVT 475
L QR ++ E W LP ++WL G P+S+LTA++Q R+N W LD L VT
Sbjct: 4304 LLQRIKELEQW--TADFALPNVVWLGGFFNPQSFLTAIMQSMARKNEWPLDKMCLQCDVT 4361
Query: 474 KVDIRSSETLTMTPEFGCYAVGFYLEGCGWNVEKGCVQPQKSRELIQSMPVIQLHPIESH 295
K ++ E + P G Y G ++EG W+ + + + +EL +MPVI + I
Sbjct: 4362 K---KNKEDFSSApreGSYVHGLFMEGARWDTQTNMIADARLKELAPNMPVIFIKAIPVD 4418
Query: 294 KYKTTNTIQVPVYVTSQRRNAMGIGLVTVLDLATTEHSSHWVLQGIALAL 145
K T N + PVY T QR G V +L + E ++ W L G+AL L
Sbjct: 4419 KQDTRNIYECPVYKTKQR----GPTFVWTFNLKSKEKAAKWTLAGVALLL 4464
>sp|P39057|DYHC_ANTCR Dynein beta chain, ciliary
Length = 4466
Score = 120 bits (300), Expect = 6e-27
Identities = 73/229 (31%), Positives = 114/229 (49%), Gaps = 1/229 (0%)
Frame = -2
Query: 828 LLKKMFTSLTILKKALVGEAGMSNELDDINRSLANGMLPNCWRILAPETMKMLGSWLEHL 649
L ++ SL L L GE ++ +++D++ +L +P W A ++ L +W L
Sbjct: 4245 LTSEIRRSLKELDLGLKGELTITPDMEDLSNALFLDQIPASWVKRAYPSLFGLSAWYADL 4304
Query: 648 QQRRRQYEAWIEAGKIDLP-IIWLSGLHLPESYLTALIQKACRRNNWALDACTLATIVTK 472
QR ++ E W LP ++WL G P+S+LTA++Q R+N W LD L VTK
Sbjct: 4305 LQRIKELEQW--TADFALPNVVWLGGFFNPQSFLTAIMQSMARKNEWPLDKMCLQCDVTK 4362
Query: 471 VDIRSSETLTMTPEFGCYAVGFYLEGCGWNVEKGCVQPQKSRELIQSMPVIQLHPIESHK 292
++ E + P G Y G ++EG W+ + + + +EL +MPVI + I K
Sbjct: 4363 ---KNKEDFSSApreGSYVHGLFMEGARWDTQTNMIADARLKELAPNMPVIFIKAIPVDK 4419
Query: 291 YKTTNTIQVPVYVTSQRRNAMGIGLVTVLDLATTEHSSHWVLQGIALAL 145
T N + PVY T QR G V +L + E ++ W L G+AL L
Sbjct: 4420 QDTRNIYECPVYKTKQR----GPTFVWTFNLKSKEKAAKWTLAGVALLL 4464
>sp|Q39565|DYHB_CHLRE Dynein beta chain, flagellar outer arm
Length = 4568
Score = 118 bits (295), Expect = 2e-26
Identities = 75/231 (32%), Positives = 114/231 (49%), Gaps = 1/231 (0%)
Frame = -2
Query: 831 LLLKKMFTSLTILKKALVGEAGMSNELDDINRSLANGMLPNCWRILAPETMKMLGSWLEH 652
+LL +M SL L L G+ M+ ++ + ++LA +P WR LA +++ LGSWL +
Sbjct: 4345 MLLAEMKRSLLELDLGLKGDLTMTEPMERLLKALATDAVPGSWRNLAYPSLRPLGSWLGN 4404
Query: 651 LQQRRRQYEAWIEAGKIDLP-IIWLSGLHLPESYLTALIQKACRRNNWALDACTLATIVT 475
L R Q W ++ P +WLSGL P+S+LTA++Q RRN+W LD + T VT
Sbjct: 4405 LLARHAQLVDW--TAELSTPKAVWLSGLFNPQSFLTAVMQATARRNDWPLDKTVIITEVT 4462
Query: 474 KVDIRSSETLTMTPEFGCYAVGFYLEGCGWNVEKGCVQPQKSRELIQSMPVIQLHPIESH 295
K + + + G + G LEG W+ + G + K +EL MPVI + +
Sbjct: 4463 K---KQPDQIEANSRDGAFIHGLTLEGARWDDKIGALDDSKPKELFCPMPVILVRAVTQD 4519
Query: 294 KYKTTNTIQVPVYVTSQRRNAMGIGLVTVLDLATTEHSSHWVLQGIALALN 142
K + + + PVY T R V L + WVL G+ L L+
Sbjct: 4520 KAEMKDVYKCPVYTTEARFREE----VFEAQLKSKHTEIKWVLAGVCLFLD 4566
>sp|Q96DT5|DYH11_HUMAN Ciliary dynein heavy chain 11 (Axonemal beta dynein heavy chain 11)
Length = 4523
Score = 115 bits (288), Expect = 2e-25
Identities = 72/232 (31%), Positives = 115/232 (49%), Gaps = 1/232 (0%)
Frame = -2
Query: 831 LLLKKMFTSLTILKKALVGEAGMSNELDDINRSLANGMLPNCWRILAPETMKMLGSWLEH 652
+L++++ SL L +L GE +S ++ +L+ +P+ W LA + L W
Sbjct: 4301 ILIREIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFND 4360
Query: 651 LQQRRRQYEAWIEAGKIDLP-IIWLSGLHLPESYLTALIQKACRRNNWALDACTLATIVT 475
L R R+ + W + + LP ++WLSG P+S+LTA++Q R+N W LD L VT
Sbjct: 4361 LLLRCRELDTWTQ--DLTLPAVVWLSGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVT 4418
Query: 474 KVDIRSSETLTMTPEFGCYAVGFYLEGCGWNVEKGCVQPQKSRELIQSMPVIQLHPIESH 295
K ++ E P G Y G ++EG W+ + G + + +EL MPVI
Sbjct: 4419 K---KTKEDYGHPpreGAYLHGLFMEGARWDTQAGTIVEARLKELACPMPVIFAKATPVD 4475
Query: 294 KYKTTNTIQVPVYVTSQRRNAMGIGLVTVLDLATTEHSSHWVLQGIALALNS 139
+ +T T + PVY T R G + L + E ++ WVL G+AL L +
Sbjct: 4476 RQETKQTYECPVYRTKLR----GPSYIWTFRLKSEEKTAKWVLAGVALLLEA 4523
>sp|Q9MBF8|DYH1B_CHLRE Dynein 1-beta heavy chain, flagellar inner arm I1 complex (1-beta
DHC) (Dynein 1, subspecies f)
Length = 4513
Score = 104 bits (260), Expect = 3e-22
Identities = 70/235 (29%), Positives = 110/235 (46%), Gaps = 6/235 (2%)
Frame = -2
Query: 828 LLKKMFTSLTILKKALVGEAGMSNELDDINRSLANGMLPNCWRILAPETMKMLGSWLEHL 649
LL + S L++ + G MS +LD I SL +P W P ++K LG W L
Sbjct: 4286 LLVAVRRSCVELQRGIKGLVVMSADLDLIFESLYAAKVPAAWLKTYP-SLKPLGPWTRDL 4344
Query: 648 QQRRRQYEAWIEAGKIDLPIIWLSGLHLPESYLTALIQKACRRNNWALDACTLATIVTKV 469
QR Q W+E + + WLSG P +LTA++Q R+ + +D + + +
Sbjct: 4345 LQRIEQLATWVE--ETYPRVYWLSGFTYPTGFLTAVLQTTARKASVPIDTLSFEFSIINL 4402
Query: 468 DIRSSETLTMTPEFGCYAVGFYLEGCGWNVEKGCVQPQKSRELIQSMPVIQLHPIESHKY 289
D R + P+ G Y G +LEG GW+ E GC+ ELI MP++ P+E+ K
Sbjct: 4403 DERE---INAPPKEGVYIKGLFLEGAGWDFENGCLCEPNPMELIVPMPILLFRPVENKKR 4459
Query: 288 KTTNTIQVPVYV------TSQRRNAMGIGLVTVLDLATTEHSSHWVLQGIALALN 142
P+Y+ T +R + M + V + + HW+++G AL L+
Sbjct: 4460 TAKGIYTCPLYLYPLRTGTRERPSFM----INVDLRSGSADPDHWIMRGTALLLS 4510
>sp|Q8TE73|DYH5_HUMAN Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5)
(HL1)
Length = 4624
Score = 104 bits (260), Expect = 3e-22
Identities = 69/227 (30%), Positives = 110/227 (48%), Gaps = 1/227 (0%)
Frame = -2
Query: 828 LLKKMFTSLTILKKALVGEAGMSNELDDINRSLANGMLPNCWRILAPETMKMLGSWLEHL 649
+L + ++LT LK A+ G MS L D + + +P W+ A LG W L
Sbjct: 4403 VLSLVRSTLTELKLAIDGTIIMSENLRDALDCMFDARIPAWWK-KASWISSTLGFWFTEL 4461
Query: 648 QQRRRQYEAWIEAGKIDLPIIWLSGLHLPESYLTALIQKACRRNN-WALDACTLATIVTK 472
+R Q+ +W+ G+ W++G P+ +LTA+ Q+ R N WALD L VTK
Sbjct: 4462 IERNSQFTSWVFNGRPHC--FWMTGFFNPQGFLTAMRQEITRANKGWALDNMVLCNEVTK 4519
Query: 471 VDIRSSETLTMTPEFGCYAVGFYLEGCGWNVEKGCVQPQKSRELIQSMPVIQLHPIESHK 292
+ ++ P G Y G YLEG GW+ + K + L + MPVI+++ E++
Sbjct: 4520 W---MKDDISAPPTEGVYVYGLYLEGAGWDKRNMKLIESKPKVLFELMPVIRIY-AENNT 4575
Query: 291 YKTTNTIQVPVYVTSQRRNAMGIGLVTVLDLATTEHSSHWVLQGIAL 151
+ P+Y R + + + +DL T + HWVL+G+AL
Sbjct: 4576 LRDPRFYSCPIYKKPVRTD---LNYIAAVDLRTAQTPEHWVLRGVAL 4619
>sp|Q8VHE6|DYH5_MOUSE Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5)
(Mdnah5)
Length = 4621
Score = 103 bits (257), Expect = 6e-22
Identities = 69/227 (30%), Positives = 109/227 (48%), Gaps = 1/227 (0%)
Frame = -2
Query: 828 LLKKMFTSLTILKKALVGEAGMSNELDDINRSLANGMLPNCWRILAPETMKMLGSWLEHL 649
+L + ++LT LK A+ G MS L D + + +P W+ A LG W L
Sbjct: 4400 VLSLVRSTLTELKLAVDGTIIMSENLRDALDCMFDARIPARWK-KASWVSSTLGFWFTEL 4458
Query: 648 QQRRRQYEAWIEAGKIDLPIIWLSGLHLPESYLTALIQKACRRNN-WALDACTLATIVTK 472
+R Q+ +W+ G+ W++G P+ +LTA+ Q+ R N WALD L VTK
Sbjct: 4459 LERNCQFTSWVSNGRPHC--FWMTGFFNPQGFLTAMRQEITRANKGWALDNMVLCNEVTK 4516
Query: 471 VDIRSSETLTMTPEFGCYAVGFYLEGCGWNVEKGCVQPQKSRELIQSMPVIQLHPIESHK 292
+ ++ P G Y G YLEG GW+ + K + L + MPVI++ E++
Sbjct: 4517 F---MKDDISAPPTEGVYVYGLYLEGAGWDKRNMKLIESKPKVLFELMPVIRIF-AENNT 4572
Query: 291 YKTTNTIQVPVYVTSQRRNAMGIGLVTVLDLATTEHSSHWVLQGIAL 151
+ P+Y R + + + +DL T + HWVL+G+AL
Sbjct: 4573 ARDPRLYCCPIYKKPVRTD---LNYIAAVDLKTAQAPEHWVLRGVAL 4616
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,506,438
Number of Sequences: 369166
Number of extensions: 1736340
Number of successful extensions: 4325
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4179
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4299
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8598109270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)