Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_K13
(852 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P13395|SPTCA_DROME Spectrin alpha chain 350 3e-96
sp|P16086|SPTA2_RAT Spectrin alpha chain, brain (Spectrin, ... 345 7e-95
sp|Q13813|SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin... 345 9e-95
sp|P07751|SPTA2_CHICK Spectrin alpha chain, brain (Spectrin... 345 1e-94
sp|P02549|SPTA1_HUMAN Spectrin alpha chain, erythrocyte (Er... 246 4e-65
sp|P08032|SPTA1_MOUSE Spectrin alpha chain, erythrocyte (Er... 241 2e-63
sp|Q00963|SPTCB_DROME Spectrin beta chain 123 6e-28
sp|P16546|SPTA2_MOUSE Spectrin alpha chain, brain (Spectrin... 117 3e-26
sp|Q01082|SPTB2_HUMAN Spectrin beta chain, brain 1 (Spectri... 116 7e-26
sp|Q62261|SPTB2_MOUSE Spectrin beta chain, brain 1 (Spectri... 108 2e-23
>sp|P13395|SPTCA_DROME Spectrin alpha chain
Length = 2415
Score = 350 bits (898), Expect = 3e-96
Identities = 166/283 (58%), Positives = 224/283 (79%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKEPIA STN GRDLIGVQNLIKKHQA+ AE+ HE R+L V + G+ M+ +A+
Sbjct: 803 IREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLKDQPFASD 862
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
DI ++++ ++ W+ LK K+ +R+Q LDDSL+A QY ADA+EAESWMREKEP+ +++G
Sbjct: 863 DIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPIATGSDYG 922
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
KDEDS+EALLKKH+AL++D+EA+ +TI +L+ QA C+ QE PV D GKE V+ALYDY
Sbjct: 923 KDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDITGKECVVALYDYT 982
Query: 541 EKNpreVSMRKGDVLTLLNSNHKDWWKVEINDRQGHVPAAYVKKVDAMMSDIDPNAPEQI 720
EK+preVSM+KGDVLTLLNSN+KDWWKVE+NDRQG VPAAY+KK+DA +S N +
Sbjct: 983 EKSpreVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQQNLVDNH 1042
Query: 721 TVASQQKNLENQYENLLSLGKDRRDRLKDSVQAYQLVREANDL 849
++A +Q + +QY+NLL+L ++R+++L ++V+AY LVREA DL
Sbjct: 1043 SIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADL 1085
Score = 122 bits (305), Expect = 2e-27
Identities = 60/144 (41%), Positives = 91/144 (63%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK+ + GS + GRDL GVQNL KKH+ ++AE+ HEP I V G+K++D ++
Sbjct: 1728 IKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLMDVSNLGVP 1787
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+IE+++ + W++LKN A R Q LD+SL QQ+LA E E+W+ EK+ L+ ++G
Sbjct: 1788 EIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYG 1847
Query: 361 KDEDSTEALLKKHDALMADIEAYR 432
+ + LLKKHDA D A++
Sbjct: 1848 DSMAAVQGLLKKHDAFETDFTAHK 1871
Score = 100 bits (249), Expect = 5e-21
Identities = 69/258 (26%), Positives = 124/258 (48%), Gaps = 15/258 (5%)
Frame = +1
Query: 28 STNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDM 207
S + G+DL VQNL KKH ++A+V H+ RI + K I+ H+ +I K ++
Sbjct: 706 SEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNL 765
Query: 208 KNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEAL 387
++ L +R+Q L DSL+ QQ D + +W+REKEP+ ST G+D + L
Sbjct: 766 SARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNL 825
Query: 388 LKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQEKNpreVSM 567
+KKH A++A+I + + + ++ + + +++ P + ++ + AL + + S
Sbjct: 826 IKKHQAVLAEINNHEARLLNVISSGEN-MLKDQPFASDDIRQRLEALQEQWNTLKEKSSQ 884
Query: 568 RKGDVLTLL-------NSNHKDWWKVEIN--------DRQGHVPAAYVKKVDAMMSDIDP 702
RK D+ L ++N + W E + A +KK +A++SD++
Sbjct: 885 RKQDLDDSLQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEA 944
Query: 703 NAPEQITVASQQKNLENQ 756
+ Q KN Q
Sbjct: 945 FGNTIQALQEQAKNCRQQ 962
Score = 100 bits (248), Expect = 7e-21
Identities = 46/149 (30%), Positives = 88/149 (59%)
Frame = +1
Query: 7 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDI 186
E E + + + G+DL VQNL+KKHQ ++A++ HE RI ++ N+ +++ + I
Sbjct: 1624 EVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQFDTAGI 1683
Query: 187 EKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKD 366
++K + + + N A R+ L+++L Q+ D ++ ESW++EK+ LVGS ++G+D
Sbjct: 1684 QEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRD 1743
Query: 367 EDSTEALLKKHDALMADIEAYRSTIDSLR 453
+ L KKH L A++ ++ I +++
Sbjct: 1744 LTGVQNLKKKHKRLEAELGSHEPAIQAVQ 1772
Score = 96.7 bits (239), Expect = 7e-20
Identities = 75/316 (23%), Positives = 140/316 (44%), Gaps = 33/316 (10%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
IHEK A + RD +Q I+KHQA +AEV+ H I+ + N GQ+MI+ H+A+
Sbjct: 63 IHEKLQAASEESY-RDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASE 121
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I+ ++D++ LW L ++ ++ L +L Q+L E W+++KE V + EFG
Sbjct: 122 SIQVRLDELHKLWELLLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFG 181
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGK---------- 510
+D + E L +K D D+ + + + AD P D+ K
Sbjct: 182 QDLEHVEVLQRKFDEFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQ 241
Query: 511 ----------ETVMALYDYQEKNpreVS-----MRKGDVLTLLNSNHKDWWKVEINDRQG 645
E + ++ Q N R+ + + DV+ + +D V+ R+
Sbjct: 242 RLKQLAIVRQEKLFGAHEIQRFN-RDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKH 300
Query: 646 HVP----AAYVKKVDAMMSDIDP----NAPEQITVASQQKNLENQYENLLSLGKDRRDRL 801
AA KV + ++ +A + +Q + N +++L + ++R+ +L
Sbjct: 301 EGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKL 360
Query: 802 KDSVQAYQLVREANDL 849
+S ++ + + DL
Sbjct: 361 DESYYLHRFLADFRDL 376
Score = 90.1 bits (222), Expect = 7e-18
Identities = 77/303 (25%), Positives = 134/303 (44%), Gaps = 36/303 (11%)
Frame = +1
Query: 46 DLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD 225
D + ++KHQ + E+ ++ RI ++ N G ++I+ HYA I ++ ++ LW
Sbjct: 606 DPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLWET 665
Query: 226 LKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDA 405
L +DK+ L+++ + QQ+ + E W+ E E + S + GKD S + L KKH
Sbjct: 666 LVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHAL 725
Query: 406 LMADIEAYRSTIDSLRT-----------QADACKMQEAPVSDSYGK------ETVMALYD 534
L AD+ A++ I+S++ AD + +E +S Y E L D
Sbjct: 726 LEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLD 785
Query: 535 -----------------YQEKNpreVSMRKGDVLTLLNSNHKDWWKV--EINDRQGHVPA 657
+EK P S +G L + + K V EIN+ + +
Sbjct: 786 SLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARL-L 844
Query: 658 AYVKKVDAMMSDIDPNAPEQITVASQQKNLENQYENLLSLGKDRRDRLKDSVQAYQLVRE 837
+ + M+ D P A + I + + L+ Q+ L R+ L DS+QA+Q +
Sbjct: 845 NVISSGENMLKD-QPFASDDI--RQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFAD 901
Query: 838 AND 846
AN+
Sbjct: 902 ANE 904
Score = 85.5 bits (210), Expect = 2e-16
Identities = 54/199 (27%), Positives = 96/199 (48%), Gaps = 2/199 (1%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I+ + S + D+ G + LI++HQ + E+ G +++ NHYA+
Sbjct: 1303 INSMMSLVTSDELANDVTGAEALIERHQEHRTEIDARAGTFGAFEQFGNELLQANHYASP 1362
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I++KI+D+ DL+ +RR L+ +L+ Q Y+ D AESWM +E + + +
Sbjct: 1363 EIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDA 1422
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSD--SYGKETVMALYD 534
+ EAL+KKH+ I + I +L+T AD Q S+ ++ V+ +
Sbjct: 1423 NAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVLERWR 1482
Query: 535 YQEKNpreVSMRKGDVLTL 591
+ ++ E R GD TL
Sbjct: 1483 HLKEGLIEKRSRLGDEQTL 1501
Score = 84.0 bits (206), Expect = 5e-16
Identities = 51/187 (27%), Positives = 96/187 (51%), Gaps = 9/187 (4%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK+ + S + GRDL VQ L +KH+ ++ ++ E ++ + E Q++ + +
Sbjct: 274 IAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSD 333
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I K ++ N W L KA +R+Q LD+S ++LAD + SW+ + ++ + E
Sbjct: 334 QIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELA 393
Query: 361 KDEDSTEALLKKHDALMADIEA----YRSTIDS-----LRTQADACKMQEAPVSDSYGKE 513
KD EALL++H +I+A ++ T +S R A ++QE + K
Sbjct: 394 KDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAAEIQEKLAALENDKS 453
Query: 514 TVMALYD 534
++++L++
Sbjct: 454 SLLSLWE 460
Score = 84.0 bits (206), Expect = 5e-16
Identities = 41/150 (27%), Positives = 80/150 (53%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I+ + I + + +D+ G + L+++HQ + E+ E GQK+++ HYA
Sbjct: 380 INGMKAIISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAA 439
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I++K+ ++N S L + + RR L + ++ Q + D +A++WM ++E + + + G
Sbjct: 440 EIQEKLAALENDKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLG 499
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
DS EAL+KKH+ + A I +L
Sbjct: 500 DSLDSVEALIKKHEDFEKSLAAQEEKIKAL 529
Score = 80.9 bits (198), Expect = 4e-15
Identities = 40/143 (27%), Positives = 75/143 (52%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK+ + + G + VQ L+KKH A + + T H+ R +C++G ++++ ++
Sbjct: 1834 ITEKQQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNHHGE 1893
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I ++ ++ +L A +R+ L D+ Q++ A ESW+ +KE V S EFG
Sbjct: 1894 SIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFG 1953
Query: 361 KDEDSTEALLKKHDALMADIEAY 429
+D + + LL K + A + A+
Sbjct: 1954 RDLSTVQTLLTKQETFDAGLNAF 1976
Score = 79.0 bits (193), Expect = 2e-14
Identities = 67/297 (22%), Positives = 131/297 (44%), Gaps = 34/297 (11%)
Frame = +1
Query: 58 VQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNK 237
V+ LIKKH+ + GHE +I + ++I NHYA+ +++K + W LK
Sbjct: 1428 VEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEG 1487
Query: 238 ADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMAD 417
++R L D QQ+ DA E E+W+ EK L + E KD + ++ +KH A A+
Sbjct: 1488 LIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQL-ATEESYKDPANIQSKHQKHQAFEAE 1546
Query: 418 IEAYRSTIDSLRTQA-------------DACKMQEAPVSDSY---GKETVMALYDYQEKN 549
+ A I S+ DA + + ++D + +T +E N
Sbjct: 1547 LAANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEAN 1606
Query: 550 P--------REVSMRKGDVLTLLNS--NHKDWWKVEINDRQGHVPAAYVKKVDAMMSDID 699
+++ G+V +LL + + KD V+ ++ + A + + + D++
Sbjct: 1607 KQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMN 1666
Query: 700 PNAPEQIT--------VASQQKNLENQYENLLSLGKDRRDRLKDSVQAYQLVREAND 846
A + + +++++ +YE + +L R+ RL +++ +Q R+ D
Sbjct: 1667 NQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIAD 1723
Score = 77.8 bits (190), Expect = 4e-14
Identities = 79/319 (24%), Positives = 133/319 (41%), Gaps = 39/319 (12%)
Frame = +1
Query: 7 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDI 186
++E + ++G L V+ LIKKH+ + + E +I + K+IDG HYA D+
Sbjct: 488 KQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALDIFATKLIDGQHYAADDV 547
Query: 187 EKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKD 366
++ + + L+ K+ KRRQLL+DS QQ+ D E + W+ EK + D
Sbjct: 548 AQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSY-LD 606
Query: 367 EDSTEALLKKHDALMADIEAYRSTIDSLRT-----------QADA--CKMQEAPV----- 492
+ ++KH ++ A +S I+ + AD +MQE V
Sbjct: 607 PTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLWETL 666
Query: 493 ---SDSYGKETVMALYDYQ-------------EKNpreVSMRKGDVLTLLNSNHKDWWKV 624
SD G + A Q E + +S G LT + + K +
Sbjct: 667 VQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALL 726
Query: 625 EIN-----DRQGHVPAAYVKKVDAMMSDIDPNAPEQITVASQQKNLENQYENLLSLGKDR 789
E + DR + A K +++ D D + +++ NL +Y L + +R
Sbjct: 727 EADVMAHQDRIESIKVAANKFIESGHFDAD-------NIRNKEGNLSARYAALAAPMGER 779
Query: 790 RDRLKDSVQAYQLVREAND 846
+ L DS+Q QL R+ D
Sbjct: 780 KQHLLDSLQVQQLFRDLED 798
Score = 76.6 bits (187), Expect = 8e-14
Identities = 41/144 (28%), Positives = 77/144 (53%), Gaps = 2/144 (1%)
Frame = +1
Query: 43 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD--IEKKIDDMKNL 216
+D +Q+ +KHQA +AE+ + RI V G +ID + + ++K++ + +
Sbjct: 1528 KDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQ 1587
Query: 217 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 396
W L +K ++ L ++ + + Y+A + + W+ E E L+ + + GKD S + L+KK
Sbjct: 1588 WEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKK 1647
Query: 397 HDALMADIEAYRSTIDSLRTQADA 468
H + ADI A+ I + QAD+
Sbjct: 1648 HQLVEADIVAHEDRIKDMNNQADS 1671
Score = 68.2 bits (165), Expect = 3e-11
Identities = 35/146 (23%), Positives = 71/146 (48%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK + ++G+DL VQ L +KH+ ++ ++ +I ++ +++ +
Sbjct: 1197 IAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQLDETANRLMQSHPDTAE 1256
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
K ++ +W + K+ R++ L DS + Q++L+D + +W+ LV S E
Sbjct: 1257 QTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELA 1316
Query: 361 KDEDSTEALLKKHDALMADIEAYRST 438
D EAL+++H +I+A T
Sbjct: 1317 NDVTGAEALIERHQEHRTEIDARAGT 1342
Score = 61.6 bits (148), Expect = 3e-09
Identities = 42/162 (25%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Frame = +1
Query: 37 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMID-GNHYANRDIEKKIDDMKN 213
VG DL V+ L KK ++ +E R+ + ++ G A I+ ++ D+
Sbjct: 1102 VGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNE 1161
Query: 214 LWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLK 393
W++L+ ++ L + E Q++ D E + W+ EK + + + GKD S + L +
Sbjct: 1162 KWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQR 1221
Query: 394 KHDALMADIEAYRSTIDSLRTQADACKMQEAP--VSDSYGKE 513
KH+ + D+ A R I L A+ MQ P +Y K+
Sbjct: 1222 KHEGVERDLAALRDKIRQLDETANRL-MQSHPDTAEQTYAKQ 1262
Score = 55.1 bits (131), Expect = 2e-07
Identities = 32/107 (29%), Positives = 58/107 (54%)
Frame = +1
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
DI+++ + + + ++D K + ++R+ L+DS Q + DA E ESW+ EK S E
Sbjct: 17 DIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQ-AASEESY 75
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDS 501
+D + +A ++KH A A++ A+ + I SL Q+ S+S
Sbjct: 76 RDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASES 122
Score = 38.9 bits (89), Expect = 0.018
Identities = 22/85 (25%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Frame = +1
Query: 175 NRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTE 354
N I K+ + + + + +L A +R+ L+++++A + +A++ W+R+KE +
Sbjct: 1041 NHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIAD 1100
Query: 355 -FGKDEDSTEALLKKHDALMADIEA 426
G+D + E L KK D D++A
Sbjct: 1101 VVGEDLEEVEVLQKKFDDFNDDLKA 1125
Score = 38.5 bits (88), Expect = 0.024
Identities = 41/184 (22%), Positives = 73/184 (39%), Gaps = 1/184 (0%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR-ILEVCNEGQKMIDGNHYAN 177
I +KE S GRDL VQ L+ K + A + E I + ++I+ +H +
Sbjct: 1940 IDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQEGIHNITALKDQLINASHAQS 1999
Query: 178 RDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEF 357
I K+ D+ W L++ ++ R+ D L Q+ E +K S
Sbjct: 2000 PAILKRHGDVIARWQKLRDASNTRK---DRLLAMQEQFRQIEELYLTFAKKASAFNSWFE 2056
Query: 358 GKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDY 537
+ED T+ + ++I+ +R DA +A +S + +A D
Sbjct: 2057 NAEEDLTDPV-------------RCNSIEEIRALRDAHAQFQASLSSAEADFKALAALDQ 2103
Query: 538 QEKN 549
+ K+
Sbjct: 2104 KIKS 2107
>sp|P16086|SPTA2_RAT Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 2472
Score = 345 bits (886), Expect = 7e-95
Identities = 173/304 (56%), Positives = 222/304 (73%), Gaps = 21/304 (6%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKEPIA STN G+DLIGVQNL+KKHQA+QAE+ GHEPRI V +G M++ H+A
Sbjct: 800 IREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAE 859
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
D++ K+ ++ W LK KA +RRQ L+DSL+AQQY ADA+EAESWMREKEP+VGST++G
Sbjct: 860 DVKAKLSELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYG 919
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
KDEDS EALLKKH+ALM+D+ AY S+I +LR QA +C+ Q AP+ D GKE V+ALYDYQ
Sbjct: 920 KDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPMDDETGKELVLALYDYQ 979
Query: 541 EKNpreVSMRKGDVLTLLNSNHKDWWKVEINDRQGHVPAAYVKKVDAMMSDIDPN-APEQ 717
EK+preV+M+KGD+LTLLNS +KDWWKVE+NDRQG VPAAYVKK+D S N EQ
Sbjct: 980 EKSpreVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQ 1039
Query: 718 ITVASQQKNLENQ--------------------YENLLSLGKDRRDRLKDSVQAYQLVRE 837
++A +Q ++NQ Y++LL LG+ R+ L+ S + + L RE
Sbjct: 1040 GSIALRQGQIDNQTRITKEAGSVSLRMKQVEELYQSLLELGEKRKGMLEKSCKKFMLFRE 1099
Query: 838 ANDL 849
AN+L
Sbjct: 1100 ANEL 1103
Score = 117 bits (294), Expect = 3e-26
Identities = 58/152 (38%), Positives = 91/152 (59%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK+ + S + GRDL GVQNL KKH+ ++AE+ HEP I V + G+K+ D N
Sbjct: 1780 IKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQE 1839
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I++++ W +LK A R Q L++SLE QQ++A+ E E+W+ EK LV S ++G
Sbjct: 1840 EIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG 1899
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRT 456
+ + LLKKH+A D ++ ++ + T
Sbjct: 1900 DTLAAIQGLLKKHEAFETDFTVHKDRVNDVCT 1931
Score = 111 bits (277), Expect = 3e-24
Identities = 77/247 (31%), Positives = 119/247 (48%), Gaps = 15/247 (6%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
++E E S + G+DL VQNL KKH ++A+V H+ RI + + ++ D H+
Sbjct: 694 LYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAE 753
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I+KK + + + LK R+Q L DSL QQ D + E+W+REKEP+ ST G
Sbjct: 754 NIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG 813
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
KD + LLKKH AL A+I + I ++ TQ ++E + K + L
Sbjct: 814 KDLIGVQNLLKKHQALQAEIAGHEPRIKAV-TQKGNAMVEEGHFAAEDVKAKLSELNQKW 872
Query: 541 EKNpreVSMRKGDVLTLL-------NSNHKDWWKVEINDRQGHV--------PAAYVKKV 675
E + S R+ D+ L ++N + W E G A +KK
Sbjct: 873 EALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKH 932
Query: 676 DAMMSDI 696
+A+MSD+
Sbjct: 933 EALMSDL 939
Score = 101 bits (252), Expect = 2e-21
Identities = 79/305 (25%), Positives = 147/305 (48%), Gaps = 37/305 (12%)
Frame = +1
Query: 43 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWS 222
+D +Q ++KHQA +AE++ ++ RI + GQK+ID NHYA ++ +++++ +LW
Sbjct: 602 KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKEEVAARMNEVISLWK 661
Query: 223 DLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHD 402
L + + L ++ + QQ+ + + E W+ E E + S ++GKD + + L KKH
Sbjct: 662 KLLEATELKGVKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHA 721
Query: 403 ALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYG----KETVMALYD------------ 534
L AD+ A++ ID + QA + Q+A D+ +E ++A Y+
Sbjct: 722 LLEADVAAHQDRIDGITIQAR--QFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
Query: 535 ----------YQEKNpreVSMRKGDVLTLLNSNHKDWWKVE--INDRQ-------GHVP- 654
+++ E +R+ + + + KD V+ + Q GH P
Sbjct: 780 LADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR 839
Query: 655 -AAYVKKVDAMMSDIDPNAPEQITVASQQKNLENQYENLLSLGKDRRDRLKDSVQAYQLV 831
A +K +AM+ + A + V ++ L ++E L + RR L+DS+QA Q
Sbjct: 840 IKAVTQKGNAMVEEGHFAAED---VKAKLSELNQKWEALKAKASQRRQDLEDSLQAQQYF 896
Query: 832 REAND 846
+AN+
Sbjct: 897 ADANE 901
Score = 99.0 bits (245), Expect = 1e-20
Identities = 57/165 (34%), Positives = 90/165 (54%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I++KE I S +G+DL V+ L KK + Q ++ HE R+ EV K+I H
Sbjct: 165 INDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAAKLIQEQHPEEE 224
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I+ K +++ W LK A +R+ L + E Q++ D E W++EKE L+ S +FG
Sbjct: 225 LIKTKQEEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIGWIKEKEQLMASDDFG 284
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVS 495
+D S +ALL+KH+ L D+ A + +L +AD + Q P+S
Sbjct: 285 RDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQ-QSHPLS 328
Score = 98.2 bits (243), Expect = 3e-20
Identities = 45/150 (30%), Positives = 85/150 (56%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E E + S + G+DL V NL+KKHQ ++A+++ HE R+ ++ ++ ++ + +
Sbjct: 1674 LSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTS 1733
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+++K D + + +K+ A RR L +S Q+ D + ESW++EK+ LV S ++G
Sbjct: 1734 QVKEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYG 1793
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
+D + L KKH L A++ A+ I +
Sbjct: 1794 RDLTGVQNLRKKHKRLEAELAAHEPAIQGV 1823
Score = 94.0 bits (232), Expect = 5e-19
Identities = 71/258 (27%), Positives = 122/258 (47%), Gaps = 8/258 (3%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I+EK + S + G L +Q L+KKH+A + + T H+ R+ +VC GQ +I N++
Sbjct: 1886 INEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE 1945
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I K+ + SDL+ A +R+ LD++ Q+ A ESW+ EKE + + ++G
Sbjct: 1946 NISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYG 2005
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
+D S + LL K + A ++A++ QE + + K+ ++A Q
Sbjct: 2006 RDLSSVQTLLTKQETFDAGLQAFQ---------------QEGIANITALKDQLLAAKHIQ 2050
Query: 541 EK--NpreVSMRKGDVLTLLNSNHKDWWKVEINDRQGH------VPAAYVKKVDAMMSDI 696
K R S+ K L NS + K ++ + Q H + + KK A S
Sbjct: 2051 SKAIEARHASLMKRWTQLLANSATR---KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWF 2107
Query: 697 DPNAPEQITVASQQKNLE 750
+ NA E +T + +LE
Sbjct: 2108 E-NAEEDLTDPVRCNSLE 2124
Score = 91.3 bits (225), Expect = 3e-18
Identities = 44/149 (29%), Positives = 79/149 (53%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKE + S + GRDL VQ L++KH+ ++ ++ E ++ +C E ++ + +
Sbjct: 271 IKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSAN 330
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I+ K +++ W ++ A +R LDDS Q++LAD + SW+ E + L+ + E
Sbjct: 331 QIQVKREELITNWEQIRTLAAERHARLDDSYRLQRFLADFRDLTSWVTEMKALINADELA 390
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDS 447
D EALL +H +I+A+ + S
Sbjct: 391 NDVAGAEALLDRHQEHKGEIDAHEDSFKS 419
Score = 84.7 bits (208), Expect = 3e-16
Identities = 77/320 (24%), Positives = 136/320 (42%), Gaps = 40/320 (12%)
Frame = +1
Query: 7 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDI 186
++E + ++G L V+ L+KKH+ + ++ E +I + K+I NHYA D+
Sbjct: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
Query: 187 EKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKD 366
+ D + + + L +A RR L DS QQ+ D+ E +SW+ EK + E KD
Sbjct: 545 ATRRDALLSRRNALHERAMHRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKD 603
Query: 367 EDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYD---- 534
+ + ++KH A A++ A +S ID+L Q+ + Y KE V A +
Sbjct: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAG-----QKLIDVNHYAKEEVAARMNEVIS 658
Query: 535 -----YQEKNpreVSMRKGDVLTLLNSNHKD--WWKVEINDRQGHVP------------- 654
+ + V +R+ + N N +D W E+ +GH+
Sbjct: 659 LWKKLLEATELKGVKLREANQQQQFNRNVEDIELWLYEV---EGHLASDDYGKDLTNVQN 715
Query: 655 ------------AAYVKKVDAMMSDI----DPNAPEQITVASQQKNLENQYENLLSLGKD 786
AA+ ++D + D + + +Q+ L +YE L
Sbjct: 716 LQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVA 775
Query: 787 RRDRLKDSVQAYQLVREAND 846
R+ +L DS++ QL R+ D
Sbjct: 776 RKQKLADSLRLQQLFRDVED 795
Score = 84.3 bits (207), Expect = 4e-16
Identities = 43/149 (28%), Positives = 76/149 (51%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK + N G DL VQ L +KH+ + ++ ++ + Q++I + +
Sbjct: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAE 1308
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
D+++K ++ W+ L +AD+R+ L DS + Q++L+D + SW+ LV S E
Sbjct: 1309 DLKEKCTELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDS 447
KD EALL++H +I+A T +
Sbjct: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQA 1397
Score = 83.2 bits (204), Expect = 8e-16
Identities = 44/149 (29%), Positives = 78/149 (52%)
Frame = +1
Query: 19 IAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKI 198
+ S + +D+ G + L+++HQ + E+ GQ+++ HYA+ +I++K+
Sbjct: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKEKL 1420
Query: 199 DDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDST 378
D + +DL+ +RR +LD LE Q + D +AE+WM +E + + + G DS
Sbjct: 1421 DILDQERTDLEKAWVQRRMMLDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
Query: 379 EALLKKHDALMADIEAYRSTIDSLRTQAD 465
EAL+KKH+ I I +L+ AD
Sbjct: 1481 EALIKKHEDFDKAINVQEEKIAALQAFAD 1509
Score = 79.3 bits (194), Expect = 1e-14
Identities = 74/318 (23%), Positives = 142/318 (44%), Gaps = 35/318 (11%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK +A N +D +Q ++KHQA +AEV + I+++ G MI H+A+
Sbjct: 60 IQEKLQVASDENY-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE 118
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I ++ ++ W L K ++ L + + QYL + + W+ +KE +V S E G
Sbjct: 119 TIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELG 178
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL-----------RTQADACKMQEAPVSDSYG 507
+D + E L KK + D+ A+ ++ + + + K ++ V+ ++
Sbjct: 179 QDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQEEVNAAWQ 238
Query: 508 KETVMALY---------DYQEKNpreVS-----MRKGDVLTLLNSNHKDWWKVE--INDR 639
+ +AL + Q N R+V +++ + L + +D V+ +
Sbjct: 239 RLKGLALQRQGKLFGAAEVQRFN-RDVDETIGWIKEKEQLMASDDFGRDLASVQALLRKH 297
Query: 640 QG--HVPAAYVKKVDAMMSDID------PNAPEQITVASQQKNLENQYENLLSLGKDRRD 795
+G AA KV A+ ++ D P + QI V +++ L +E + +L +R
Sbjct: 298 EGLERDLAALEDKVKALCAEADRLQQSHPLSANQIQV--KREELITNWEQIRTLAAERHA 355
Query: 796 RLKDSVQAYQLVREANDL 849
RL DS + + + + DL
Sbjct: 356 RLDDSYRLQRFLADFRDL 373
Score = 77.8 bits (190), Expect = 4e-14
Identities = 44/150 (29%), Positives = 78/150 (52%), Gaps = 2/150 (1%)
Frame = +1
Query: 43 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD--IEKKIDDMKNL 216
+D +Q+ +KHQA +AE+ + RI V + G +I+ A + ++ ++ + +
Sbjct: 1580 KDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQ 1639
Query: 217 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 396
W L K+ ++ Q L ++ + Q + + + W+ E E L+ S ++GKD S LLKK
Sbjct: 1640 WQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKK 1699
Query: 397 HDALMADIEAYRSTIDSLRTQADACKMQEA 486
H L ADI A+ + L +QAD+ A
Sbjct: 1700 HQLLEADISAHEDRLKDLNSQADSLMTSSA 1729
Score = 77.0 bits (188), Expect = 6e-14
Identities = 37/150 (24%), Positives = 73/150 (48%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E + + + + D+ G + L+ +HQ + E+ HE GQ ++ HYA+
Sbjct: 377 VTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASD 436
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
++ +K+ + + L + RRQ + ++ Q + D + ++WM ++E + + + G
Sbjct: 437 EVREKLSILSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
DS EALLKKH+ + A I +L
Sbjct: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITAL 526
Score = 71.6 bits (174), Expect = 3e-12
Identities = 71/313 (22%), Positives = 133/313 (42%), Gaps = 34/313 (10%)
Frame = +1
Query: 10 KEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIE 189
+E + + G L V+ LIKKH+ + E +I + ++I +HYA DI
Sbjct: 1464 REAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAVDHYAKGDIA 1523
Query: 190 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE 369
+ +++ + W LK + ++R L +S QQ+ D E E+W+ EK S E KD
Sbjct: 1524 NRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ-TASDESYKDP 1582
Query: 370 DSTEALLKKHDALMADIEA----YRSTID---------SLRTQADACKMQEAPVSDSY-- 504
+ ++ +KH A A++ A R ID + DA K + A ++D +
Sbjct: 1583 TNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQF 1642
Query: 505 ----GKETVMALYDYQEKNpreVSMRKGD-----VLTLLNSNH--KDWWKVEINDRQGHV 651
E L + ++ ++ D V LL S KD V ++ +
Sbjct: 1643 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQL 1702
Query: 652 PAAYVKKVDAMMSDIDPNAPEQIT--------VASQQKNLENQYENLLSLGKDRRDRLKD 807
A + + + D++ A +T V ++ + +++ + S+ RR +L +
Sbjct: 1703 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSE 1762
Query: 808 SVQAYQLVREAND 846
S + +Q R+ +D
Sbjct: 1763 SHRLHQFFRDMDD 1775
Score = 62.4 bits (150), Expect = 2e-09
Identities = 44/187 (23%), Positives = 78/187 (41%), Gaps = 37/187 (19%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I+EKE S VG DL V+ L KK Q ++ +E R+ ++ N+ + ++
Sbjct: 1107 INEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDI-NKVAEDLESEGLMAE 1165
Query: 181 DIE-------------------------------------KKIDDMKNLWSDLKNKADKR 249
+++ I ++ W L+ A++R
Sbjct: 1166 EVQAVQQQEVYGMMPRDEADSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEER 1225
Query: 250 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 429
QLL + E Q++ DA E + W+ EK + + +G D S +AL +KH+ D+ A
Sbjct: 1226 SQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAAL 1285
Query: 430 RSTIDSL 450
++SL
Sbjct: 1286 GDKVNSL 1292
Score = 51.2 bits (121), Expect = 4e-06
Identities = 25/94 (26%), Positives = 47/94 (50%)
Frame = +1
Query: 184 IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGK 363
+ ++ ++ L+ L +KR+ +L+ S + +A+E + W+ EKE + S E G
Sbjct: 1062 VSLRMKQVEELYQSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGA 1121
Query: 364 DEDSTEALLKKHDALMADIEAYRSTIDSLRTQAD 465
D + E L KK D D++A S + + A+
Sbjct: 1122 DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAE 1155
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/90 (33%), Positives = 47/90 (52%)
Frame = +1
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
DI+++ + + + K + RRQ L+DS Q + DA E E W++EK V S E
Sbjct: 14 DIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-VASDENY 72
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
KD + + L+KH A A+++A I L
Sbjct: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKL 102
>sp|Q13813|SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 2472
Score = 345 bits (885), Expect = 9e-95
Identities = 173/304 (56%), Positives = 221/304 (72%), Gaps = 21/304 (6%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKEPIA STN G+DLIGVQNL+KKHQA+QAE+ GHEPRI V +G M++ H+A
Sbjct: 800 IREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAE 859
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
D++ K+ ++ W LK KA +RRQ L+DSL+AQQY ADA+EAESWMREKEP+VGST++G
Sbjct: 860 DVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYG 919
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
KDEDS EALLKKH+ALM+D+ AY S+I +LR QA +C+ Q AP D GKE V+ALYDYQ
Sbjct: 920 KDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ 979
Query: 541 EKNpreVSMRKGDVLTLLNSNHKDWWKVEINDRQGHVPAAYVKKVDAMMSDIDPN-APEQ 717
EK+preV+M+KGD+LTLLNS +KDWWKVE+NDRQG VPAAYVKK+D S N EQ
Sbjct: 980 EKSpreVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQ 1039
Query: 718 ITVASQQKNLENQ--------------------YENLLSLGKDRRDRLKDSVQAYQLVRE 837
++A +Q+ ++NQ Y +LL LG+ R+ L+ S + + L RE
Sbjct: 1040 GSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
Query: 838 ANDL 849
AN+L
Sbjct: 1100 ANEL 1103
Score = 120 bits (300), Expect = 6e-27
Identities = 59/152 (38%), Positives = 92/152 (60%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK+ + GS + GRDL GVQNL KKH+ ++AE+ HEP I V + G+K+ D N
Sbjct: 1780 IKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKE 1839
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I++++ W +LK A R Q L++SLE QQ++A+ E E+W+ EK LV S ++G
Sbjct: 1840 EIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG 1899
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRT 456
+ + LLKKH+A D ++ ++ + T
Sbjct: 1900 DTLAAIQGLLKKHEAFETDFTVHKDRVNDVCT 1931
Score = 110 bits (276), Expect = 4e-24
Identities = 77/247 (31%), Positives = 119/247 (48%), Gaps = 15/247 (6%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
++E E S + G+DL VQNL KKH ++A+V H+ RI + + ++ D H+
Sbjct: 694 LYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAE 753
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I+KK + + + LK R+Q L DSL QQ D + E+W+REKEP+ ST G
Sbjct: 754 NIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG 813
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
KD + LLKKH AL A+I + I ++ TQ ++E + K + L
Sbjct: 814 KDLIGVQNLLKKHQALQAEIAGHEPRIKAV-TQKGNAMVEEGHFAAEDVKAKLHELNQKW 872
Query: 541 EKNpreVSMRKGDVLTLL-------NSNHKDWWKVEINDRQGHV--------PAAYVKKV 675
E + S R+ D+ L ++N + W E G A +KK
Sbjct: 873 EALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKH 932
Query: 676 DAMMSDI 696
+A+MSD+
Sbjct: 933 EALMSDL 939
Score = 102 bits (253), Expect = 2e-21
Identities = 59/165 (35%), Positives = 91/165 (55%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I++KE I S +G+DL V+ L KK + Q ++ HE R+ EV K+I H
Sbjct: 165 INDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE 224
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I+ K D++ W LK A +R+ L + E Q++ D E SW++EKE L+ S +FG
Sbjct: 225 LIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFG 284
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVS 495
+D S +ALL+KH+ L D+ A + +L +AD + Q P+S
Sbjct: 285 RDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQ-QSHPLS 328
Score = 100 bits (248), Expect = 7e-21
Identities = 79/305 (25%), Positives = 147/305 (48%), Gaps = 37/305 (12%)
Frame = +1
Query: 43 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWS 222
+D +Q ++KHQA +AE++ ++ RI + GQK+ID NHYA ++ +++++ +LW
Sbjct: 602 KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWK 661
Query: 223 DLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHD 402
L + + L ++ + QQ+ + + E W+ E E + S ++GKD + + L KKH
Sbjct: 662 KLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHA 721
Query: 403 ALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYG----KETVMALYD------------ 534
L AD+ A++ ID + QA + Q+A D+ +E ++A Y+
Sbjct: 722 LLEADVAAHQDRIDGITIQAR--QFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
Query: 535 ----------YQEKNpreVSMRKGDVLTLLNSNHKDWWKVE--INDRQ-------GHVP- 654
+++ E +R+ + + + KD V+ + Q GH P
Sbjct: 780 LADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR 839
Query: 655 -AAYVKKVDAMMSDIDPNAPEQITVASQQKNLENQYENLLSLGKDRRDRLKDSVQAYQLV 831
A +K +AM+ + A + V ++ L ++E L + RR L+DS+QA Q
Sbjct: 840 IKAVTQKGNAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYF 896
Query: 832 REAND 846
+AN+
Sbjct: 897 ADANE 901
Score = 99.8 bits (247), Expect = 9e-21
Identities = 46/150 (30%), Positives = 86/150 (57%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E E + S + G+DL V NL+KKHQ ++A+++ HE R+ ++ ++ ++ + +
Sbjct: 1674 LSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTS 1733
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
++ K D + + +K+ A RR L++S Q+ D + ESW++EK+ LVGS ++G
Sbjct: 1734 QVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG 1793
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
+D + L KKH L A++ A+ I +
Sbjct: 1794 RDLTGVQNLRKKHKRLEAELAAHEPAIQGV 1823
Score = 93.6 bits (231), Expect = 6e-19
Identities = 51/162 (31%), Positives = 89/162 (54%), Gaps = 4/162 (2%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I+EK + S + G L +Q L+KKH+A + + T H+ R+ +VC GQ +I N++
Sbjct: 1886 INEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE 1945
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I K+ + SDL+ A +R+ LD++ Q+ A ESW+ EKE + + ++G
Sbjct: 1946 NISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYG 2005
Query: 361 KDEDSTEALLKKHDALMADIEAYR----STIDSLRTQADACK 474
+D S + LL K + A ++A++ + I +L+ Q A K
Sbjct: 2006 RDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAK 2047
Score = 89.0 bits (219), Expect = 2e-17
Identities = 43/149 (28%), Positives = 79/149 (53%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKE + S + GRDL VQ L++KH+ ++ ++ E ++ +C E ++ + +
Sbjct: 271 IKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSAT 330
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I+ K +++ W ++ A +R L+DS Q++LAD + SW+ E + L+ + E
Sbjct: 331 QIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELA 390
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDS 447
D EALL +H +I+A+ + S
Sbjct: 391 SDVAGAEALLDRHQEHKGEIDAHEDSFKS 419
Score = 84.3 bits (207), Expect = 4e-16
Identities = 75/320 (23%), Positives = 137/320 (42%), Gaps = 40/320 (12%)
Frame = +1
Query: 7 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDI 186
++E + ++G L V+ L+KKH+ + ++ E +I + K+I NHYA D+
Sbjct: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
Query: 187 EKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKD 366
+ D + + + L +A +RR L DS QQ+ D+ E +SW+ EK + E KD
Sbjct: 545 ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKD 603
Query: 367 EDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYD---- 534
+ + ++KH A A++ A +S ID+L Q+ + Y K+ V A +
Sbjct: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAG-----QKLIDVNHYAKDEVAARMNEVIS 658
Query: 535 -----YQEKNpreVSMRKGDVLTLLNSNHKD--WWKVEINDRQGHVP------------- 654
+ + + +R+ + N N +D W E+ +GH+
Sbjct: 659 LWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEV---EGHLASDDYGKDLTNVQN 715
Query: 655 ------------AAYVKKVDAMMSDI----DPNAPEQITVASQQKNLENQYENLLSLGKD 786
AA+ ++D + D + + +Q+ L +YE L
Sbjct: 716 LQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVA 775
Query: 787 RRDRLKDSVQAYQLVREAND 846
R+ +L DS++ QL R+ D
Sbjct: 776 RKQKLADSLRLQQLFRDVED 795
Score = 83.6 bits (205), Expect = 6e-16
Identities = 44/149 (29%), Positives = 78/149 (52%)
Frame = +1
Query: 19 IAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKI 198
+ S + +D+ G + L+++HQ + E+ GQ+++ HYA+ +I++K+
Sbjct: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKL 1420
Query: 199 DDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDST 378
D + +DL+ +RR +LD LE Q + D +AE+WM +E + + + G DS
Sbjct: 1421 DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
Query: 379 EALLKKHDALMADIEAYRSTIDSLRTQAD 465
EAL+KKH+ I I +L+ AD
Sbjct: 1481 EALIKKHEDFDKAINVQEEKIAALQAFAD 1509
Score = 82.8 bits (203), Expect = 1e-15
Identities = 42/149 (28%), Positives = 75/149 (50%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK + N G DL VQ L +KH+ + ++ ++ + +++ + +
Sbjct: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLTQSHPESAE 1308
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
D+++K ++ WS L +AD+R+ L DS + Q++L+D + SW+ LV S E
Sbjct: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDS 447
KD EALL++H +I+A T +
Sbjct: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQA 1397
Score = 79.0 bits (193), Expect = 2e-14
Identities = 75/318 (23%), Positives = 142/318 (44%), Gaps = 35/318 (11%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK IA N +D +Q ++KHQA +AEV + I+++ G MI H+A+
Sbjct: 60 IQEKLQIASDENY-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE 118
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I ++ ++ W L K ++ L + + QYL + + W+ +KE +V S E G
Sbjct: 119 TIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELG 178
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL-----------RTQADACKMQEAPVSDSYG 507
+D + E L KK + D+ A+ ++ + + + K ++ V+ ++
Sbjct: 179 QDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQ 238
Query: 508 KETVMALY---------DYQEKNpreVS-----MRKGDVLTLLNSNHKDWWKVE--INDR 639
+ +AL + Q N R+V +++ + L + +D V+ +
Sbjct: 239 RLKGLALQRQGKLFGAAEVQRFN-RDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH 297
Query: 640 QG--HVPAAYVKKVDAMMSDID------PNAPEQITVASQQKNLENQYENLLSLGKDRRD 795
+G AA KV A+ ++ D P + QI V +++ L +E + +L +R
Sbjct: 298 EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQV--KREELITNWEQIRTLAAERHA 355
Query: 796 RLKDSVQAYQLVREANDL 849
RL DS + + + + DL
Sbjct: 356 RLNDSYRLQRFLADFRDL 373
Score = 77.8 bits (190), Expect = 4e-14
Identities = 44/150 (29%), Positives = 78/150 (52%), Gaps = 2/150 (1%)
Frame = +1
Query: 43 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD--IEKKIDDMKNL 216
+D +Q+ +KHQA +AE+ + RI V + G +I+ A + ++ ++ + +
Sbjct: 1580 KDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQ 1639
Query: 217 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 396
W L K+ ++ Q L ++ + Q + + + W+ E E L+ S ++GKD S LLKK
Sbjct: 1640 WQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKK 1699
Query: 397 HDALMADIEAYRSTIDSLRTQADACKMQEA 486
H L ADI A+ + L +QAD+ A
Sbjct: 1700 HQLLEADISAHEDRLKDLNSQADSLMTSSA 1729
Score = 76.3 bits (186), Expect = 1e-13
Identities = 37/150 (24%), Positives = 73/150 (48%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E + + + + D+ G + L+ +HQ + E+ HE GQ ++ HYA+
Sbjct: 377 VTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASD 436
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
++ +K+ + + L + RRQ + ++ Q + D + ++WM ++E + + + G
Sbjct: 437 EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
DS EALLKKH+ + A I +L
Sbjct: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITAL 526
Score = 72.8 bits (177), Expect = 1e-12
Identities = 71/313 (22%), Positives = 132/313 (42%), Gaps = 34/313 (10%)
Frame = +1
Query: 10 KEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIE 189
+E + + G L V+ LIKKH+ + E +I + ++I HYA DI
Sbjct: 1464 REAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDIS 1523
Query: 190 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE 369
+ +++ + W LK + ++R L +S QQ+ D E E+W+ EK S E KD
Sbjct: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ-TASDESYKDP 1582
Query: 370 DSTEALLKKHDALMADIEA----YRSTID---------SLRTQADACKMQEAPVSDSY-- 504
+ ++ +KH A A++ A R ID + DA K + A ++D +
Sbjct: 1583 TNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQF 1642
Query: 505 ----GKETVMALYDYQEKNpreVSMRKGD-----VLTLLNSNH--KDWWKVEINDRQGHV 651
E L + ++ ++ D V LL S KD V ++ +
Sbjct: 1643 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQL 1702
Query: 652 PAAYVKKVDAMMSDIDPNAPEQIT--------VASQQKNLENQYENLLSLGKDRRDRLKD 807
A + + + D++ A +T V ++ + +++ + S+ RR +L +
Sbjct: 1703 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNE 1762
Query: 808 SVQAYQLVREAND 846
S + +Q R+ +D
Sbjct: 1763 SHRLHQFFRDMDD 1775
Score = 63.2 bits (152), Expect = 9e-10
Identities = 45/192 (23%), Positives = 80/192 (41%), Gaps = 37/192 (19%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I+EKE S VG DL V+ L KK Q ++ +E R+ ++ N+ + ++
Sbjct: 1107 INEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDI-NKVAEDLESEGLMAE 1165
Query: 181 DIE-------------------------------------KKIDDMKNLWSDLKNKADKR 249
+++ I ++ W L+ A++R
Sbjct: 1166 EVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEER 1225
Query: 250 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 429
QLL + E Q++ DA E + W+ EK + + +G D S +AL +KH+ D+ A
Sbjct: 1226 SQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAAL 1285
Query: 430 RSTIDSLRTQAD 465
++SL A+
Sbjct: 1286 GDKVNSLGETAE 1297
Score = 51.2 bits (121), Expect = 4e-06
Identities = 28/110 (25%), Positives = 53/110 (48%), Gaps = 3/110 (2%)
Frame = +1
Query: 145 QKMIDGNHYANRD---IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAES 315
Q+ ID ++ + ++ ++ L+ L +KR+ +L+ S + +A+E +
Sbjct: 1046 QEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQ 1105
Query: 316 WMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQAD 465
W+ EKE + S E G D + E L KK D D++A S + + A+
Sbjct: 1106 WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAE 1155
Score = 48.9 bits (115), Expect = 2e-05
Identities = 29/90 (32%), Positives = 47/90 (52%)
Frame = +1
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
DI+++ + + + K + RRQ L+DS Q + DA E E W++EK + S E
Sbjct: 14 DIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-IASDENY 72
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
KD + + L+KH A A+++A I L
Sbjct: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKL 102
>sp|P07751|SPTA2_CHICK Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Fodrin alpha chain)
Length = 2477
Score = 345 bits (884), Expect = 1e-94
Identities = 172/304 (56%), Positives = 222/304 (73%), Gaps = 21/304 (6%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKEPIA STN G+DLIGVQNL+KKHQA+QAE+ GHEPRI V +G M++ H+A
Sbjct: 800 IREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAE 859
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
D++ K++++ W LK KA +RRQ L+DSL+AQQY ADA+EA+SWMREKEP+VGST++G
Sbjct: 860 DVKIKLNELNQKWDSLKAKASQRRQDLEDSLQAQQYFADANEAQSWMREKEPIVGSTDYG 919
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
KDEDS EALLKKH+ALM+D+ AY S+I +LR QA +C+ Q AP D GKE V+ALYDYQ
Sbjct: 920 KDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ 979
Query: 541 EKNpreVSMRKGDVLTLLNSNHKDWWKVEINDRQGHVPAAYVKKVDAMMSDIDPN-APEQ 717
EK+preV+M+KGD+LTLLNS +KDWWKVE+NDRQG VPAAYVKK+D S N EQ
Sbjct: 980 EKSpreVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQ 1039
Query: 718 ITVASQQKNLENQ--------------------YENLLSLGKDRRDRLKDSVQAYQLVRE 837
++A +Q+ ++NQ Y +LL LG+ R+ L+ S + + L RE
Sbjct: 1040 GSIALRQEQIDNQTLITKEVGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
Query: 838 ANDL 849
AN+L
Sbjct: 1100 ANEL 1103
Score = 117 bits (293), Expect = 4e-26
Identities = 57/150 (38%), Positives = 91/150 (60%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK+ + S + GRDL GVQNL KKH+ ++AE+ HEP I V + G+K+ D N
Sbjct: 1785 IKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKE 1844
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I++++ + W +LK A R Q L++SLE QQ++A+ E E+W+ EK LV S ++G
Sbjct: 1845 EIQQRLAQFVDHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG 1904
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
+ + LLKKH+A D ++ ++ +
Sbjct: 1905 DTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
Score = 105 bits (261), Expect = 2e-22
Identities = 75/247 (30%), Positives = 118/247 (47%), Gaps = 15/247 (6%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
++E E S + G+DL VQNL KKH ++A+V H+ I + + ++ D H+
Sbjct: 694 LYEVEGHLASDDYGKDLTSVQNLQKKHALLEADVAAHQDPIDGITIQARQFQDAGHFDAD 753
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I+KK + + + LK+ R+Q L DSL QQ D + E+W+REKEP+ ST G
Sbjct: 754 NIKKKQEALVARYEALKDPMVARKQKLADSLRLQQLFRDIEDEETWIREKEPIAASTNRG 813
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
KD + LLKKH AL A+I + I ++ TQ ++E + K + L
Sbjct: 814 KDLIGVQNLLKKHQALQAEIAGHEPRIKAV-TQKGNAMVEEGHFAAEDVKIKLNELNQKW 872
Query: 541 EKNpreVSMRKGDVLTLL-------NSNHKDWWKVEINDRQGHV--------PAAYVKKV 675
+ + S R+ D+ L ++N W E G A +KK
Sbjct: 873 DSLKAKASQRRQDLEDSLQAQQYFADANEAQSWMREKEPIVGSTDYGKDEDSAEALLKKH 932
Query: 676 DAMMSDI 696
+A+MSD+
Sbjct: 933 EALMSDL 939
Score = 102 bits (253), Expect = 2e-21
Identities = 58/167 (34%), Positives = 92/167 (55%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I++KE I S +G+DL V+ L KK + Q ++ HE R+ EV K+I H
Sbjct: 165 INDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAGKLIQEQHPEEE 224
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I+ K D++ W LK A +R+ L + E Q++ D E SW++EK L+ S +FG
Sbjct: 225 LIKSKQDEVNASWQRLKGLAQQRQGKLFGAAEVQRFNRDVDETISWIKEKGQLMASDDFG 284
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDS 501
+D S +ALL+KH+ L D+ A+ + +L +AD + Q P++ S
Sbjct: 285 RDLASVQALLRKHEGLERDLAAFHHKVKALCAEADRLQ-QSHPINAS 330
Score = 100 bits (249), Expect = 5e-21
Identities = 80/306 (26%), Positives = 147/306 (48%), Gaps = 38/306 (12%)
Frame = +1
Query: 43 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWS 222
+D +Q ++KHQA +AE++ ++ RI + GQK+ID NHYA+ ++ +++++ +LW
Sbjct: 602 KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYASDEVAARMNEVISLWK 661
Query: 223 DLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHD 402
L + + L ++ + QQ+ + + E W+ E E + S ++GKD S + L KKH
Sbjct: 662 KLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTSVQNLQKKHA 721
Query: 403 ALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYG----KETVMALYD------------ 534
L AD+ A++ ID + QA + Q+A D+ +E ++A Y+
Sbjct: 722 LLEADVAAHQDPIDGITIQAR--QFQDAGHFDADNIKKKQEALVARYEALKDPMVARKQK 779
Query: 535 --------------------YQEKNpreVSMRKGDVLTLLNSNHKDWWKVEINDRQGHVP 654
+EK P S +G L + + K ++ + GH P
Sbjct: 780 LADSLRLQQLFRDIEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA-EIAGHEP 838
Query: 655 --AAYVKKVDAMMSDIDPNAPEQITVASQQKNLENQYENLLSLGKDRRDRLKDSVQAYQL 828
A +K +AM+ + A E + + + L ++++L + RR L+DS+QA Q
Sbjct: 839 RIKAVTQKGNAMVEE-GHFAAEDVKI--KLNELNQKWDSLKAKASQRRQDLEDSLQAQQY 895
Query: 829 VREAND 846
+AN+
Sbjct: 896 FADANE 901
Score = 95.1 bits (235), Expect = 2e-19
Identities = 44/150 (29%), Positives = 85/150 (56%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E E + S + G+DL V NL+KKHQ ++A+++ HE R+ ++ ++ ++ + +
Sbjct: 1679 LSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTS 1738
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
++ K + + + +K+ A RR L++S Q+ D + ESW++EK+ LV S ++G
Sbjct: 1739 QVKDKRETINGRFQRIKSMAAARRAKLNESHRLHQFFRDMDDEESWIKEKKLLVSSEDYG 1798
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
+D + L KKH L A++ A+ I +
Sbjct: 1799 RDLTGVQNLRKKHKRLEAELAAHEPAIQGV 1828
Score = 91.7 bits (226), Expect = 2e-18
Identities = 51/162 (31%), Positives = 90/162 (55%), Gaps = 4/162 (2%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I+EK + S + G L +Q L+KKH+A + + T H+ R+ +VC G+ +I N++
Sbjct: 1891 INEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCANGEDLIKKNNHHVE 1950
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I K+ +K SDL+ A +R+ LD++ Q+ A ESW+ EKE + + ++G
Sbjct: 1951 NITAKMKGLKGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYG 2010
Query: 361 KDEDSTEALLKKHDALMADIEAYR----STIDSLRTQADACK 474
+D S + LL K + A ++A++ + I +L+ Q A K
Sbjct: 2011 RDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAK 2052
Score = 83.2 bits (204), Expect = 8e-16
Identities = 47/167 (28%), Positives = 84/167 (50%)
Frame = +1
Query: 19 IAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKI 198
+ S + +D+ G + L+++HQ + E+ GQ+++ HYA+ +I++K+
Sbjct: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLARGHYASPEIKEKL 1420
Query: 199 DDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDST 378
D + +DL+ +RR +LD LE Q + D +AE+WM +E + + + G DS
Sbjct: 1421 DILDQERTDLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
Query: 379 EALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETV 519
EAL+KKH+ I I L++ AD + +D Y K +
Sbjct: 1481 EALIKKHEDFDKAINVQEEKIAVLQSFAD-----QLIAADHYAKGVI 1522
Score = 82.8 bits (203), Expect = 1e-15
Identities = 48/178 (26%), Positives = 84/178 (47%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK + S + GRDL VQ L++KH+ ++ ++ ++ +C E ++ +
Sbjct: 271 IKEKGQLMASDDFGRDLASVQALLRKHEGLERDLAAFHHKVKALCAEADRLQQSHPINAS 330
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I+ K +++ W ++ A +R L+DS Q++LAD + SW+ E + L+ + E
Sbjct: 331 QIQVKREELIANWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELA 390
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYD 534
D EALL +H +I+A+ + S A SD KE + L D
Sbjct: 391 NDVAGAEALLDRHQEHKGEIDAHEDSFRSADESGQALLAAGHYASDEV-KEKLTILSD 447
Score = 82.4 bits (202), Expect = 1e-15
Identities = 45/163 (27%), Positives = 82/163 (50%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK IA N +D +Q ++KHQA +AEV + I+++ G +MI+ H+A+
Sbjct: 60 IQEKLQIASDENY-KDPSNLQGKLQKHQAFEAEVQANSGAIVKLDETGNQMINEGHFASE 118
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I ++ ++ LW L K ++ L + + Q+L + + W+ +KE +V S E G
Sbjct: 119 TIRTRLQELHRLWELLLEKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAIVTSEELG 178
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAP 489
+D + E L KK + D+ A+ ++ + A ++ P
Sbjct: 179 QDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAGKLIQEQHP 221
Score = 82.4 bits (202), Expect = 1e-15
Identities = 75/315 (23%), Positives = 134/315 (42%), Gaps = 35/315 (11%)
Frame = +1
Query: 7 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDI 186
++E + ++G L V+ L+KKH+ + ++ E +I + K+I NHYA D+
Sbjct: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMDDV 544
Query: 187 EKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKD 366
+ D + + + L +A KRR L DS QQ+ D+ E +SW+ EK + E KD
Sbjct: 545 ATRRDALLSRRNALHERAMKRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKD 603
Query: 367 EDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYG--KETVMALYD-- 534
+ + ++KH A A++ A +S ID+L SD V++L+
Sbjct: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYASDEVAARMNEVISLWKKL 663
Query: 535 YQEKNpreVSMRKGDVLTLLNSNHKD--WWKVEINDRQGHVP------------------ 654
+ + + +R+ + N N +D W E+ +GH+
Sbjct: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEV---EGHLASDDYGKDLTSVQNLQKKH 720
Query: 655 -------AAYVKKVDAMMSDI----DPNAPEQITVASQQKNLENQYENLLSLGKDRRDRL 801
AA+ +D + D + + +Q+ L +YE L R+ +L
Sbjct: 721 ALLEADVAAHQDPIDGITIQARQFQDAGHFDADNIKKKQEALVARYEALKDPMVARKQKL 780
Query: 802 KDSVQAYQLVREAND 846
DS++ QL R+ D
Sbjct: 781 ADSLRLQQLFRDIED 795
Score = 80.9 bits (198), Expect = 4e-15
Identities = 42/149 (28%), Positives = 74/149 (49%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK + N G DL VQ L + + + ++ ++ + Q++I +
Sbjct: 1249 IEEKNQALNTDNYGHDLASVQALQRNDEGFERDLAALGDKVNSLGETAQRLIQSHPELAE 1308
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
D+++K ++ WS L +AD+R++ L DS + Q++L+D + SW+ LV S E
Sbjct: 1309 DLQEKCTELNQAWSSLGKRADQRKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDS 447
KD EALL++H +I+A T +
Sbjct: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQA 1397
Score = 78.6 bits (192), Expect = 2e-14
Identities = 38/150 (25%), Positives = 75/150 (50%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E + + + + D+ G + L+ +HQ + E+ HE GQ ++ HYA+
Sbjct: 377 VTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFRSADESGQALLAAGHYASD 436
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
++++K+ + + S L + RRQ + ++ Q + D + ++WM ++E + + + G
Sbjct: 437 EVKEKLTILSDERSALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
DS EALLKKH+ + A I +L
Sbjct: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITAL 526
Score = 74.7 bits (182), Expect = 3e-13
Identities = 42/140 (30%), Positives = 72/140 (51%), Gaps = 2/140 (1%)
Frame = +1
Query: 73 KKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD--IEKKIDDMKNLWSDLKNKADK 246
+KHQA +AE+ + RI V G +I+ A + ++ ++ + + W L K+ +
Sbjct: 1595 QKHQAFEAELHANADRIRGVIEMGNPLIERGACAGSEDAVKARLAALADQWEFLVQKSSE 1654
Query: 247 RRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEA 426
+ Q L ++ + Q + + + W+ E E L+ S ++GKD S LLKKH L ADI A
Sbjct: 1655 KSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISA 1714
Query: 427 YRSTIDSLRTQADACKMQEA 486
+ + L +QAD+ A
Sbjct: 1715 HEDRLKDLNSQADSLMTSSA 1734
Score = 64.7 bits (156), Expect = 3e-10
Identities = 68/323 (21%), Positives = 132/323 (40%), Gaps = 44/323 (13%)
Frame = +1
Query: 10 KEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIE 189
+E + + G L V+ LIKKH+ + E +I + + ++I +HYA I
Sbjct: 1464 REAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAVLQSFADQLIAADHYAKGVIA 1523
Query: 190 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE 369
+ +++ + W LK + ++R L +S QQ+ D E E+W+ EK S E KD
Sbjct: 1524 NRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ-TASDESYKDP 1582
Query: 370 DSTE--ALLKKHDALMADIEAYRSTIDSLR---------TQADACKMQEAPVSDSYGKET 516
+ + LL KH A + D +R + AC E V K
Sbjct: 1583 TNIQLSKLLSKHQKHQAFEAELHANADRIRGVIEMGNPLIERGACAGSEDAV-----KAR 1637
Query: 517 VMALYD-----YQEKNpreVSMRKGDVLTLLNSNHK--DWWKVEIND------------- 636
+ AL D Q+ + + +++ + N+ K D+W E+
Sbjct: 1638 LAALADQWEFLVQKSSEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLAS 1697
Query: 637 -----RQGHVPAAYVKKVDAMMSDIDPNAPEQIT--------VASQQKNLENQYENLLSL 777
++ + A + + + D++ A +T V +++ + +++ + S+
Sbjct: 1698 VNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRETINGRFQRIKSM 1757
Query: 778 GKDRRDRLKDSVQAYQLVREAND 846
RR +L +S + +Q R+ +D
Sbjct: 1758 AAARRAKLNESHRLHQFFRDMDD 1780
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/187 (21%), Positives = 75/187 (40%), Gaps = 37/187 (19%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I+EKE + VG DL V+ L KK Q ++ +E R+ ++ N+ ++
Sbjct: 1107 INEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDI-NKVANDLESEGLMAE 1165
Query: 181 DIE-------------------------------------KKIDDMKNLWSDLKNKADKR 249
+++ I ++ W L+ A++R
Sbjct: 1166 EVQAVEHQEVYGMMPRDETDSKTVSPWKSARMMVHTVATFNSIKELNERWRSLQQLAEER 1225
Query: 250 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 429
QLL + E Q++ DA E + W+ EK + + +G D S +AL + + D+ A
Sbjct: 1226 SQLLGSADEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRNDEGFERDLAAL 1285
Query: 430 RSTIDSL 450
++SL
Sbjct: 1286 GDKVNSL 1292
Score = 50.1 bits (118), Expect = 8e-06
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 3/110 (2%)
Frame = +1
Query: 145 QKMIDGNHYANRDIEK---KIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAES 315
Q+ ID +++ ++ ++ L+ L +KR+ +L+ S + +A+E +
Sbjct: 1046 QEQIDNQTLITKEVGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQ 1105
Query: 316 WMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQAD 465
W+ EKE + + E G D + E L KK D D++A S + + A+
Sbjct: 1106 WINEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAN 1155
Score = 47.8 bits (112), Expect = 4e-05
Identities = 53/260 (20%), Positives = 100/260 (38%), Gaps = 38/260 (14%)
Frame = +1
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
DI+++ + + + K + RRQ L+DS Q + DA E W++EK + S E
Sbjct: 14 DIQERRQQVLDRYHRFKELSSLRRQKLEDSYRFQFFQRDADELGKWIQEKLQ-IASDENY 72
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETV------- 519
KD + + L+KH A A+++A I L + + + ET+
Sbjct: 73 KDPSNLQGKLQKHQAFEAEVQANSGAIVKLDETGN-----QMINEGHFASETIRTRLQEL 127
Query: 520 -----MALYDYQEKNpreVSMRK--------GDVLTLLNSNHKDWWKVEINDRQGHVPAA 660
+ L +EK + + +K DV+ +N E+ HV
Sbjct: 128 HRLWELLLEKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVL 187
Query: 661 YVKKVDAMMSD------------------IDPNAPEQITVASQQKNLENQYENLLSLGKD 786
KK + +D I PE+ + S+Q + ++ L L +
Sbjct: 188 Q-KKFEEFQTDLAAHEERVNEVNQFAGKLIQEQHPEEELIKSKQDEVNASWQRLKGLAQQ 246
Query: 787 RRDRLKDSVQAYQLVREAND 846
R+ +L + + + R+ ++
Sbjct: 247 RQGKLFGAAEVQRFNRDVDE 266
>sp|P02549|SPTA1_HUMAN Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin)
Length = 2418
Score = 246 bits (629), Expect = 4e-65
Identities = 124/289 (42%), Positives = 186/289 (64%), Gaps = 6/289 (2%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I E EP A ST +G+DLI + L+ +H+ I + HEPRI E+ G KM++ H+A
Sbjct: 809 IQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAE 868
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
D+ ++ + L+ +A +R+ L+ +++ QQYLAD EAE+W+REKEP+V +T +G
Sbjct: 869 DVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYG 928
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQE-APVSDSYGKETVMALYDY 537
DE++ ALLKKH+A + D+ ++ ++ +LR QA+AC+ Q+ APV G++ VMALYD+
Sbjct: 929 ADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDF 988
Query: 538 QEKNpreVSMRKGDVLTLLNSNHKDWWKVEINDRQGHVPAAYVKKVDAMMSDIDPNAP-- 711
Q ++preV+M+KGDVLTLL+S +KDWWKVE D QG VPA YV++ + D P P
Sbjct: 989 QARSpreVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRR---LAHDEFPMLPQR 1045
Query: 712 ---EQITVASQQKNLENQYENLLSLGKDRRDRLKDSVQAYQLVREANDL 849
E + +Q+ +ENQY +LL ++RR RL + L EA D+
Sbjct: 1046 RREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDM 1094
Score = 99.4 bits (246), Expect = 1e-20
Identities = 58/184 (31%), Positives = 93/184 (50%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK S + GRDL GVQNL+KKH+ ++ E+ HEP I V + +K+ D
Sbjct: 1728 IEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQE 1787
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I+ ++ W LK A R L++SLE Q++ +A E E+W+ EK L + G
Sbjct: 1788 EIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCG 1847
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
+T++LL KH+AL D + + + ++ Q + + + +S KE +
Sbjct: 1848 DTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDI-LNKVLHEESQNKEISSKIEALN 1906
Query: 541 EKNP 552
EK P
Sbjct: 1907 EKTP 1910
Score = 80.5 bits (197), Expect = 5e-15
Identities = 45/155 (29%), Positives = 80/155 (51%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I +KE IA S +G D + L KK + Q E+ E R++EV + + NH
Sbjct: 174 IGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLP 233
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I+ K +++ W L+ A +R++ L ++ Q++ D +EA W++EKEP++ S ++G
Sbjct: 234 LIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYG 293
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQAD 465
KD ++E L H L ++ + L +A+
Sbjct: 294 KDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAE 328
Score = 76.3 bits (186), Expect = 1e-13
Identities = 50/167 (29%), Positives = 84/167 (50%)
Frame = +1
Query: 19 IAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKI 198
+ S + DL G++ L+++HQ +A++ P + + ++ID H+A+ +IEKK+
Sbjct: 1311 MVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKL 1370
Query: 199 DDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDST 378
+K DL+ +KR+++LD LE Q + + + ES M +E + S + DS
Sbjct: 1371 QAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESRMVARENSLRSDD-KSSLDSL 1429
Query: 379 EALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETV 519
EAL+KK D L I A I L A++ E Y KE +
Sbjct: 1430 EALMKKRDDLDKAITAQEGKITDLEHFAESLIADE-----HYAKEEI 1471
Score = 75.5 bits (184), Expect = 2e-13
Identities = 43/181 (23%), Positives = 84/181 (46%), Gaps = 3/181 (1%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
++EK + + D+ G + L+ +HQ + E+ ++ R GQ +++ NH A+
Sbjct: 386 MNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASD 445
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
++ +K++ + N W+ L D+R + + L+ + D+ + +SWM +E + + + G
Sbjct: 446 EVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLG 505
Query: 361 KDEDSTEALLKKHDALMADIEAYRS---TIDSLRTQADACKMQEAPVSDSYGKETVMALY 531
S EALL+KH+ A T+D T+ D Y E + A+
Sbjct: 506 NSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIG--------DDHYDSENIKAIR 557
Query: 532 D 534
D
Sbjct: 558 D 558
Score = 74.3 bits (181), Expect = 4e-13
Identities = 41/162 (25%), Positives = 78/162 (48%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E E + + RDL NL+KKHQ ++ E+ E + ++ + ++ +
Sbjct: 1622 LSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVD 1681
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I KK D++ + +++ A + L ++ Q+ D + ESW+ EK V S ++G
Sbjct: 1682 QIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYG 1741
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEA 486
+D + LLKKH L ++ A+ I ++ A+ K + A
Sbjct: 1742 RDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAA 1783
Score = 70.1 bits (170), Expect = 7e-12
Identities = 34/150 (22%), Positives = 83/150 (55%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I++K+ +A + +D+ +++ ++K Q + E+ ++ ++ + GQ+MI+G HYA+
Sbjct: 598 INKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASD 656
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
++ ++ ++ +LW +L ++ L ++ + Q+ +A + + W+ + E V S ++G
Sbjct: 657 NVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYG 716
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
K + L+KH L + + A + +D L
Sbjct: 717 KGLAEVQNRLRKHGLLESAVAARQDQVDIL 746
Score = 68.2 bits (165), Expect = 3e-11
Identities = 35/149 (23%), Positives = 69/149 (46%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKEP+ S + G+DL+ + L H+ ++ + ++ E+C + +K+ +
Sbjct: 280 IKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAP 339
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I++ +D+ + W ++ A R + L + ++ +D E WM EK + + E
Sbjct: 340 QIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELP 399
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDS 447
D E LL +H +I++Y S
Sbjct: 400 TDVAGGEVLLDRHQQHKHEIDSYDDRFQS 428
Score = 67.0 bits (162), Expect = 6e-11
Identities = 36/148 (24%), Positives = 73/148 (49%)
Frame = +1
Query: 46 DLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD 225
D +Q +KHQ+++AEV + E+ ++ H A+ + + I+++++LW
Sbjct: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDL 142
Query: 226 LKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDA 405
L ++ L +L+ QQY+ + ++ W+ +KE + S E G+D + TE L KK +
Sbjct: 143 LLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFED 202
Query: 406 LMADIEAYRSTIDSLRTQADACKMQEAP 489
++ A + + A+ C + P
Sbjct: 203 FQVELVAKEGRVVEVNQYANECAEENHP 230
Score = 65.9 bits (159), Expect = 1e-10
Identities = 33/150 (22%), Positives = 76/150 (50%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I +K + + G DL VQ L ++H+ + ++ ++ + +++ + + A
Sbjct: 1199 IEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATE 1258
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
D++++ ++ W DL+ + R++ L+++ + +L+ A + ++W+ +V S E
Sbjct: 1259 DLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELA 1318
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
+D E LL++H AD+EA T +L
Sbjct: 1319 EDLTGIEILLERHQEHRADMEAEAPTFQAL 1348
Score = 63.9 bits (154), Expect = 5e-10
Identities = 38/147 (25%), Positives = 71/147 (48%), Gaps = 3/147 (2%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDG---NHY 171
I+EK +A + G L Q+L+ KH+A++ + HE R+ VC +G+ +++
Sbjct: 1834 INEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLHEES 1893
Query: 172 ANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGST 351
N++I KI+ + L + L+D Q++ A E+W+ +KE + +
Sbjct: 1894 QNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTN 1953
Query: 352 EFGKDEDSTEALLKKHDALMADIEAYR 432
G D LL K D L A +++++
Sbjct: 1954 GNGADLGDFLTLLAKQDTLDASLQSFQ 1980
Score = 62.0 bits (149), Expect = 2e-09
Identities = 35/141 (24%), Positives = 70/141 (49%)
Frame = +1
Query: 28 STNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDM 207
S + G+ L VQN ++KH +++ V + ++ + + + H ++DI + + +
Sbjct: 712 SEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESL 771
Query: 208 KNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEAL 387
+ LK R++ L D L Q D + E+W++E EP ST GKD +++ L
Sbjct: 772 VCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKL 831
Query: 388 LKKHDALMADIEAYRSTIDSL 450
L +H ++ +I ++ I +
Sbjct: 832 LNRHRVILENIASHEPRIQEI 852
Score = 62.0 bits (149), Expect = 2e-09
Identities = 35/142 (24%), Positives = 68/142 (47%), Gaps = 1/142 (0%)
Frame = +1
Query: 43 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD-IEKKIDDMKNLW 219
+D +Q KHQ EV G ++ V N G +I+ + N + ++++++ +K W
Sbjct: 1529 KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIERSCDGNEEAMKEQLEQLKEHW 1588
Query: 220 SDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKH 399
L + + + + L+++ Q++ + E W+ E E L+ + +D S LLKKH
Sbjct: 1589 DHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKH 1648
Query: 400 DALMADIEAYRSTIDSLRTQAD 465
L ++ A + L T A+
Sbjct: 1649 QLLEREMLAREDALKDLNTLAE 1670
Score = 61.6 bits (148), Expect = 3e-09
Identities = 33/148 (22%), Positives = 77/148 (52%)
Frame = +1
Query: 10 KEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIE 189
+E + ++G L + L++KH+ + T E +I+ V K+I +HY + +I+
Sbjct: 495 QEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIK 554
Query: 190 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE 369
D + L+ KA RR+LL +SL Q+ D+ + ++W+ +K+ L ++ KD
Sbjct: 555 AIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY-KDI 613
Query: 370 DSTEALLKKHDALMADIEAYRSTIDSLR 453
+ ++ ++K ++ ++ +++++
Sbjct: 614 QNLKSRVQKQQVFEKELAVNKTQLENIQ 641
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/129 (21%), Positives = 60/129 (46%)
Frame = +1
Query: 34 NVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKN 213
N G +L V L KK Q ++ +EPR+ ++ ++ + + ++
Sbjct: 1105 NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELNA 1163
Query: 214 LWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLK 393
W L+ AD++RQLL + + + +A + + + +K + + + G D S +AL +
Sbjct: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQR 1223
Query: 394 KHDALMADI 420
+H+ D+
Sbjct: 1224 RHEGFERDL 1232
Score = 40.4 bits (93), Expect = 0.006
Identities = 32/159 (20%), Positives = 74/159 (46%), Gaps = 2/159 (1%)
Frame = +1
Query: 115 PRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLA 294
P+ V + G K+++ +I+++ ++ + K + +R Q L+DS Q +
Sbjct: 5 PKETVVESSGPKVLE----TAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKR 60
Query: 295 DASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACK 474
DA + W+ EK ++ + +D + + +KH +L A+++ T L ++ + +
Sbjct: 61 DADDLGKWIMEKVNILTDKSY-EDPTNIQGKYQKHQSLEAEVQ----TKSRLMSELEKTR 115
Query: 475 MQEAPVSDSYGKETVMALYDYQE--KNpreVSMRKGDVL 585
+ + S +ET + + + E+++ KGD L
Sbjct: 116 EERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQL 154
>sp|P08032|SPTA1_MOUSE Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin)
Length = 2415
Score = 241 bits (614), Expect = 2e-63
Identities = 118/286 (41%), Positives = 181/286 (63%), Gaps = 3/286 (1%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I E EP A ST++G+DL+ +NL+ +H+ I A++ HEPRI + G KM++ H+A
Sbjct: 807 IQETEPSAASTHLGKDLVAAKNLLNRHEVILADIASHEPRIQVITERGNKMVEEGHFAAE 866
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
DI +++ + L +A +R L +++ QQYLAD EAE+W++EKEP+V + +G
Sbjct: 867 DIASRVESLNKNMESLHARAIRRENDLKANVQLQQYLADLHEAEAWIKEKEPIVDNKNYG 926
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKET-VMALYDY 537
DE++ ALLKKH+A + D+ A+ ++I +LR QA+ C+ Q+A D G+E V+ALYD+
Sbjct: 927 ADEEAAGALLKKHEAFLVDLNAFENSIKALRDQAEVCQQQQAAPVDEAGREARVIALYDF 986
Query: 538 QEKNpreVSMRKGDVLTLLNSNHKDWWKVEINDRQGHVPAAYVKKV--DAMMSDIDPNAP 711
+ ++ REVSM+K DVLTLL+S +KDWWKVE +D QG VPA YV+K+ D +
Sbjct: 987 EARSRREVSMKKNDVLTLLSSINKDWWKVEADDHQGFVPAVYVRKLAPDELPGFPQHQRE 1046
Query: 712 EQITVASQQKNLENQYENLLSLGKDRRDRLKDSVQAYQLVREANDL 849
E + + Q+ +E Y +LL ++RR RL + L EA D+
Sbjct: 1047 EPVNIPQLQQQVETLYHSLLDRAEERRRRLLQRYNEFLLAYEAGDM 1092
Score = 97.1 bits (240), Expect = 6e-20
Identities = 51/155 (32%), Positives = 84/155 (54%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK S + GRDL VQNL+KKH+ ++ E+ HEP + V + + + D
Sbjct: 1727 IEEKLLRVSSQDYGRDLQSVQNLLKKHKRLEGELVAHEPAVQNVLDTAESLRDKAAVGKE 1786
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I++++ W LK A R L++SLE Q++ +A E E+W+ EK LV + G
Sbjct: 1787 EIQERLAQFVQHWEKLKELAKTRGVNLEESLEYLQFMENAEEEEAWLGEKCALVSRGDSG 1846
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQAD 465
+T++LLKKH+AL D +++ + + Q +
Sbjct: 1847 DTLAATQSLLKKHEALENDFAVHKNRVQDVCAQGE 1881
Score = 79.3 bits (194), Expect = 1e-14
Identities = 44/173 (25%), Positives = 89/173 (51%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E E + + RDL NL+KKHQ ++AE+ E + ++ + Q++I +
Sbjct: 1621 LSEAEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLAREDPLKDLNDLAQELISSGTFNID 1680
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
IE+K++ + + ++++ A + L ++ Q+ D + E+W+ EK V S ++G
Sbjct: 1681 QIEEKMNGVNERFENVQSLAAAHHEKLKETYALFQFFQDLDDEEAWIEEKLLRVSSQDYG 1740
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETV 519
+D S + LLKKH L ++ A+ + ++ A++ + + A GKE +
Sbjct: 1741 RDLQSVQNLLKKHKRLEGELVAHEPAVQNVLDTAESLRDKAA-----VGKEEI 1788
Score = 79.0 bits (193), Expect = 2e-14
Identities = 47/155 (30%), Positives = 76/155 (49%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ EKE I +G D + L KK + Q E+T + ++ V + H
Sbjct: 172 VKEKEAIVTLVELGDDWERTEVLHKKFEEFQEELTARKGKVDRVNQYANECAQEKHPKLP 231
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I+ K D++ W L + A KRR+ L ++ + Q++ D +EA WM EKEP + S ++G
Sbjct: 232 EIKAKQDEVNAAWDRLWSLALKRRESLSNAADLQRFKRDVNEAIQWMEEKEPQLTSEDYG 291
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQAD 465
KD S+EAL H L ++ + L +AD
Sbjct: 292 KDLVSSEALFHNHKRLERNLAVMDDKVKELCAKAD 326
Score = 78.2 bits (191), Expect = 3e-14
Identities = 47/176 (26%), Positives = 84/176 (47%)
Frame = +1
Query: 7 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDI 186
EK + + + D+ + L+ +HQ + E+ ++ R GQ+++DGNH A+ +I
Sbjct: 386 EKTALINADELPTDVASGEALLARHQQHKHEIDSYDDRFQSADATGQELLDGNHEASEEI 445
Query: 187 EKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKD 366
+K+ + N W+ L DK + L+ + D+ + +SWM +E + + + G
Sbjct: 446 REKMTILANDWAALLELWDKCQHQYRQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNS 505
Query: 367 EDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYD 534
S EALL+KHD A I +L A K+ + +D Y E + A+ D
Sbjct: 506 VGSVEALLQKHDDFEEAFTAQEEKIITL--DETATKLID---NDHYDSENIAAIRD 556
Score = 77.0 bits (188), Expect = 6e-14
Identities = 63/272 (23%), Positives = 127/272 (46%), Gaps = 7/272 (2%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E E S + G+ L VQNL++KH ++++VT + ++ + + + H +
Sbjct: 701 LEEVEWQVTSEDYGKVLADVQNLLRKHGLLESDVTARQNQMDTLTDMAAHFEEIGHPDSG 760
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
DI + + + + + LK R++ L D L+ QQ D+ + E+W++E EP ST G
Sbjct: 761 DIRARQESLLSRFEALKEPLAIRKKKLIDLLKLQQICRDSEDEEAWIQETEPSAASTHLG 820
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
KD + + LL +H+ ++ADI ++ I + + + KM E + E + + +
Sbjct: 821 KDLVAAKNLLNRHEVILADIASHEPRIQVITERGN--KMVE---EGHFAAEDIASRVESL 875
Query: 541 EKNpreVSMRKGDVLTLLNSNHKDWWKVEINDRQG--HVPAAYVKKVDAMMSDIDPNAPE 714
KN + R L +N V++ H A++K+ + ++ + + A E
Sbjct: 876 NKNMESLHARAIRRENDLKAN------VQLQQYLADLHEAEAWIKEKEPIVDNKNYGADE 929
Query: 715 QITVASQQKNLE-----NQYENLLSLGKDRRD 795
+ A +K+ N +EN + +D+ +
Sbjct: 930 EAAGALLKKHEAFLVDLNAFENSIKALRDQAE 961
Score = 72.4 bits (176), Expect = 1e-12
Identities = 39/154 (25%), Positives = 85/154 (55%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I++K+ +A + +D+ +++ ++K Q + E+ +E + + GQ+MI+ HYA+
Sbjct: 596 INKKKKLADDDDY-KDVQNLKSRVQKQQDFEEELAVNEIMLNNLEKTGQEMIEDGHYASE 654
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+ ++ ++ NLW +L ++ L ++ + Q+ +A + + W+ E E V S ++G
Sbjct: 655 AVAARLSEVANLWKELLEATAQKGTQLYEANQLLQFENNAEDLKRWLEEVEWQVTSEDYG 714
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQA 462
K + LL+KH L +D+ A ++ +D+L A
Sbjct: 715 KVLADVQNLLRKHGLLESDVTARQNQMDTLTDMA 748
Score = 70.9 bits (172), Expect = 4e-12
Identities = 55/233 (23%), Positives = 104/233 (44%), Gaps = 3/233 (1%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ EKEP S + G+DL+ + L H+ ++ + + ++ E+C + K++ +
Sbjct: 278 MEEKEPQLTSEDYGKDLVSSEALFHNHKRLERNLAVMDDKVKELCAKADKLMISHSADAL 337
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I++ D+ + W ++ A R L S ++L+D E WM+EK L+ + E
Sbjct: 338 QIQQMKLDLVSNWERIRALATNRYAKLKASYGYHRFLSDYDELSGWMKEKTALINADELP 397
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
D S EALL +H +I++Y S +D+ G+E + ++
Sbjct: 398 TDVASGEALLARHQQHKHEIDSYDDRFQS---------------ADATGQELLDGNHEAS 442
Query: 541 EKNpreVSMRKGDVLTLLNSNHKDWWKVEINDRQ---GHVPAAYVKKVDAMMS 690
E+ ++++ D LL W K + RQ H+ ++VD+ MS
Sbjct: 443 EEIREKMTILANDWAALLEL----WDKCQHQYRQCLDFHLFYRDSEQVDSWMS 491
Score = 70.9 bits (172), Expect = 4e-12
Identities = 46/170 (27%), Positives = 81/170 (47%), Gaps = 1/170 (0%)
Frame = +1
Query: 19 IAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKI 198
+ S + DL G + L+++HQ ++ +P + + G ++ID H R+I+ +
Sbjct: 1309 VISSPELAEDLTGTEILLERHQEHHDDIKREDPTFQALEDFGTELIDSGHRNRREIDNTL 1368
Query: 199 DDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE-DS 375
++ + +L+ + R+++LD LE Q + + ESWM +E + S + +D DS
Sbjct: 1369 QNINSKRDNLEKSWENRKKMLDQCLELQLFRGKCDQVESWMVARENSLRSDD--RDHLDS 1426
Query: 376 TEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMA 525
+AL+KK D L I A I L A +D Y KE + A
Sbjct: 1427 LQALMKKRDDLDKAITAQEGKISDLENVA-----TRLIDNDHYAKEEIAA 1471
Score = 70.9 bits (172), Expect = 4e-12
Identities = 48/165 (29%), Positives = 81/165 (49%), Gaps = 5/165 (3%)
Frame = +1
Query: 7 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD- 183
EK + + G L Q+L+KKH+A++ + H+ R+ +VC +G+ +++ N+D
Sbjct: 1835 EKCALVSRGDSGDTLAATQSLLKKHEALENDFAVHKNRVQDVCAQGEDILNKEETQNKDK 1894
Query: 184 IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGK 363
I KI + + L + LDD QQ+ A ESW+ EKE + + G
Sbjct: 1895 ISTKIQVLNEKTASLAKALAAWKSQLDDVHAFQQFNWKADVVESWIGEKEASLKTKSNGA 1954
Query: 364 DEDSTEALLKKHDALMADIEAYR----STIDSLRTQADACKMQEA 486
D + LL KHD L A +++++ S I L+ Q A + +A
Sbjct: 1955 DLTAFLTLLAKHDTLDASLQSFQQERLSEIAELKDQLVAGEHSQA 1999
Score = 62.8 bits (151), Expect = 1e-09
Identities = 33/144 (22%), Positives = 68/144 (47%)
Frame = +1
Query: 58 VQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNK 237
+Q +KH++ +EV + E+ + +H+A+ + + ++ LW L
Sbjct: 85 IQGKYQKHESFVSEVQAKSRVLPELEEIREARFAEDHFAHEATKTHLKQLRLLWDLLLEL 144
Query: 238 ADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMAD 417
++ +L +L+ QY + + W++EKE +V E G D + TE L KK + +
Sbjct: 145 TQEKSDVLLRALKFYQYSQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKKFEEFQEE 204
Query: 418 IEAYRSTIDSLRTQADACKMQEAP 489
+ A + +D + A+ C ++ P
Sbjct: 205 LTARKGKVDRVNQYANECAQEKHP 228
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/159 (27%), Positives = 75/159 (47%), Gaps = 5/159 (3%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI-----DGN 165
I+E PIA + +D +Q KHQA + EV G ++ V N G +I DG+
Sbjct: 1514 INEMLPIACDESY-KDPTNIQRKYLKHQAFENEVNGRAEQVDGVINLGNSLIERRVCDGD 1572
Query: 166 HYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVG 345
++++++D +K W L + + Q L+++ Q++ + E W+ E E L+
Sbjct: 1573 E---ENMQEQLDMLKENWDYLLERTTDKGQKLNEASRQQRFNTSIRDFEFWLSEAEGLLA 1629
Query: 346 STEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQA 462
+ +D S LLKKH L A++ A + L A
Sbjct: 1630 MKDQARDLTSAGNLLKKHQLLEAEMLAREDPLKDLNDLA 1668
Score = 61.2 bits (147), Expect = 3e-09
Identities = 68/317 (21%), Positives = 132/317 (41%), Gaps = 38/317 (11%)
Frame = +1
Query: 10 KEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIE 189
+E + ++G + V+ L++KH + T E +I+ + K+ID +HY + +I
Sbjct: 493 QEAFLENEDLGNSVGSVEALLQKHDDFEEAFTAQEEKIITLDETATKLIDNDHYDSENIA 552
Query: 190 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE 369
D + L+ +A RR+LL DS QQ D+ + ++W+ +K+ L ++ KD
Sbjct: 553 AIRDGLLARRDALRERAATRRKLLVDSQLLQQLYQDSDDLKTWINKKKKLADDDDY-KDV 611
Query: 370 DSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQE-- 543
+ ++ ++K ++ +++L QE Y E V A
Sbjct: 612 QNLKSRVQKQQDFEEELAVNEIMLNNLEKTG-----QEMIEDGHYASEAVAARLSEVANL 666
Query: 544 -KNpreVSMRKGDVLTLLN---------SNHKDW-----WKVEINDRQGHVPA---AYVK 669
K E + +KG L N + K W W+V D G V A ++
Sbjct: 667 WKELLEATAQKGTQLYEANQLLQFENNAEDLKRWLEEVEWQVTSED-YGKVLADVQNLLR 725
Query: 670 KVDAMMSDI------------------DPNAPEQITVASQQKNLENQYENLLSLGKDRRD 795
K + SD+ + P+ + ++Q++L +++E L R+
Sbjct: 726 KHGLLESDVTARQNQMDTLTDMAAHFEEIGHPDSGDIRARQESLLSRFEALKEPLAIRKK 785
Query: 796 RLKDSVQAYQLVREAND 846
+L D ++ Q+ R++ D
Sbjct: 786 KLIDLLKLQQICRDSED 802
Score = 60.5 bits (145), Expect = 6e-09
Identities = 61/303 (20%), Positives = 124/303 (40%), Gaps = 37/303 (12%)
Frame = +1
Query: 49 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 228
L +Q L+KK + +T E +I ++ N ++ID +HYA +I ++ + + W L
Sbjct: 1424 LDSLQALMKKRDDLDKAITAQEGKISDLENVATRLIDNDHYAKEEIAARLQRVLDRWKAL 1483
Query: 229 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 408
K + L D + +Q+ D + E W+ E P + E KD + + KH A
Sbjct: 1484 KEQLLTELGKLGDYADLKQFYRDLEDLEEWINEMLP-IACDESYKDPTNIQRKYLKHQAF 1542
Query: 409 MADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQEKNpreVSMRKGDVLT 588
++ +D + ++ + E V D +E + D ++N + R D
Sbjct: 1543 ENEVNGRAEQVDGVINLGNS--LIERRVCDG-DEENMQEQLDMLKENWDYLLERTTDKGQ 1599
Query: 589 LLNSNHK-----------DWWKVE------INDRQGHVPAA--YVKKVDAM--------- 684
LN + ++W E + D+ + +A +KK +
Sbjct: 1600 KLNEASRQQRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLARED 1659
Query: 685 -MSDIDPNAPEQIT--------VASQQKNLENQYENLLSLGKDRRDRLKDSVQAYQLVRE 837
+ D++ A E I+ + + + ++EN+ SL ++LK++ +Q ++
Sbjct: 1660 PLKDLNDLAQELISSGTFNIDQIEEKMNGVNERFENVQSLAAAHHEKLKETYALFQFFQD 1719
Query: 838 AND 846
+D
Sbjct: 1720 LDD 1722
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/151 (21%), Positives = 68/151 (45%), Gaps = 7/151 (4%)
Frame = +1
Query: 34 NVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI-------DGNHYANRDIEK 192
N G +L V L KK Q ++ +EPR+ ++ +++ +G H
Sbjct: 1103 NTGVELDDVWELQKKFDEFQRDLKSNEPRLKDINKVADELLFEELLTPEGAHIRQ----- 1157
Query: 193 KIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDED 372
++ W+ LK AD++ QLL + + + +A + + + +K + + + G D
Sbjct: 1158 ---ELNTRWNSLKRLADEQYQLLSSAHAVEMFHREADDVKEQIDKKCRALNAADPGSDLL 1214
Query: 373 STEALLKKHDALMADIEAYRSTIDSLRTQAD 465
S +AL ++H+ DI +++L A+
Sbjct: 1215 SVQALQRQHECFERDIIPLGEKVNTLGETAE 1245
Score = 41.2 bits (95), Expect = 0.004
Identities = 38/174 (21%), Positives = 66/174 (37%), Gaps = 9/174 (5%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTG-HEPRILEVCNEGQKMIDGNHYAN 177
I EKE + + G DL L+ KH + A + + R+ E+ +++ G H
Sbjct: 1940 IGEKEASLKTKSNGADLTAFLTLLAKHDTLDASLQSFQQERLSEIAELKDQLVAGEHSQA 1999
Query: 178 RDIEKKIDDMKNLWSDLKNKADKRRQ-LLDDSLEAQ-------QYLADASEAESWMREKE 333
+ IE++ + W L + RQ LL+ L Q ++ AS +W E
Sbjct: 2000 KAIEEQHAALLRHWEQLLEASRVHRQKLLEKQLPLQKAEELFMEFAHKASAFNNWCENAE 2059
Query: 334 PLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVS 495
+ + L K+H+A +A + + + L K P S
Sbjct: 2060 EDMSEPVHCVSLNEIRQLQKEHEAFLASLAGAQEDFNYLLELDKQIKALNVPSS 2113
>sp|Q00963|SPTCB_DROME Spectrin beta chain
Length = 2291
Score = 123 bits (309), Expect = 6e-28
Identities = 64/150 (42%), Positives = 89/150 (59%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK P+A S + G L V L KK+Q++ E+ HEPRI +CN G+K+ID H +
Sbjct: 1503 IDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAK 1562
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
E I D+ W +LK+ + RR+ L +S + QQY DA EAESWM E+E + + G
Sbjct: 1563 KFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRG 1622
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
KDE S + L+KKH+ L +E Y +TI L
Sbjct: 1623 KDEISAQNLMKKHENLEQSVEDYANTIRQL 1652
Score = 116 bits (291), Expect = 7e-26
Identities = 55/162 (33%), Positives = 97/162 (59%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKE I + VG DL V ++ KH+A+++E+T H+P++ V G ++I H+
Sbjct: 651 IKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGAD 710
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I+ ++ ++ N W L + RRQ L++++E Q ADA + ++WM + +V S + G
Sbjct: 711 RIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVG 770
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEA 486
+DE + ++LLKKH + +++ Y ID+L QA++ K+ EA
Sbjct: 771 RDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEA 812
Score = 85.1 bits (209), Expect = 2e-16
Identities = 73/319 (22%), Positives = 150/319 (47%), Gaps = 38/319 (11%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI--DGNHYA 174
+ E + + + + G+ L+GV++L++KH ++A++ R+ V QK + D Y
Sbjct: 540 MEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYK 599
Query: 175 NRDIE---KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVG 345
D E ++ +++ +++L A +RR L++S + Q+ D ++ E+W++EKE +V
Sbjct: 600 PCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVS 659
Query: 346 STEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL-----------RTQADACKMQEAPV 492
+ E G D + +L KH AL ++I ++ + ++ AD K + +
Sbjct: 660 TDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEI 719
Query: 493 SDSYGKETVMALYDYQE-----------KNpreVSMRKGDVLTLLNSNHKDWWKVEINDR 639
+ + + Y Q + +V D L +++S +D + E N +
Sbjct: 720 LNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSS--EDVGRDEANVQ 777
Query: 640 ---QGHVPAA-----YVKKVDAMMSDIDP---NAPEQITVASQQKNLENQYENLLSLGKD 786
+ H A Y + +DA+ + N E+ V + + ++N+Y+ L L K
Sbjct: 778 SLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKL 837
Query: 787 RRDRLKDSVQAYQLVREAN 843
R+ RL D++ Y+L+ EA+
Sbjct: 838 RKQRLLDALSLYKLMSEAD 856
Score = 80.5 bits (197), Expect = 5e-15
Identities = 43/136 (31%), Positives = 75/136 (55%)
Frame = +1
Query: 43 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWS 222
RD+ GV+ L+ HQ+++AE+ E + G++++ NHYA+ DI+ ++ + N +
Sbjct: 1942 RDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRN 2001
Query: 223 DLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHD 402
L + ++R + L LE Q+ DA+ AE+W+ +EP + S+E G D E L+KKH+
Sbjct: 2002 ALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHE 2061
Query: 403 ALMADIEAYRSTIDSL 450
A A +L
Sbjct: 2062 AFEKSAAAQEERFSAL 2077
Score = 74.7 bits (182), Expect = 3e-13
Identities = 80/329 (24%), Positives = 146/329 (44%), Gaps = 46/329 (13%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR---ILEVCNEGQKMIDGNHY 171
+ E + + N G DL V+ KKH+AI+ ++ +E R ++ VC+E + + H
Sbjct: 434 LSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELES--ERYHD 491
Query: 172 ANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGST 351
R + +K D++ LW+ L RR L+ SL+ QQ + M E + L+ +
Sbjct: 492 VKRILLRK-DNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTD 550
Query: 352 EFGKDEDSTEALLKKHDALMADIEAYRSTI-----DSLRTQAD-------------ACKM 477
++GK E LL+KH + ADI + +S + +D ++
Sbjct: 551 DYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRV 610
Query: 478 QEAPVSDSYGKETVMALYDYQEKNpreVSMRKGDVLTLLNSNHKDWWK----VEINDRQG 645
Q+ + D+Y + +A+ E+ R RK ++ ++W K + D G
Sbjct: 611 QQ--LEDAYAELVRLAV----ERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVG 664
Query: 646 H---VPAAYVKKVDAMMSDIDPNAPEQITVA------------------SQQKNLENQYE 762
H + K A+ S+I + P+ VA + K + N+++
Sbjct: 665 HDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWD 724
Query: 763 NLLSLGKDRRDRLKDSVQAYQLVREANDL 849
+LL L K RR RL+++V+ +QL +A+D+
Sbjct: 725 HLLDLTKYRRQRLENAVEYFQLFADADDV 753
Score = 67.8 bits (164), Expect = 4e-11
Identities = 39/160 (24%), Positives = 81/160 (50%)
Frame = +1
Query: 19 IAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKI 198
I S +VGRD VQ+L+KKH+ + E+ + +++ ++ + + N +++K++
Sbjct: 763 IVSSEDVGRDEANVQSLLKKHKDVADELKNYA-EVIDALHKQAESLKLNEAEKANVDKRL 821
Query: 199 DDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDST 378
+ + N + +L A R+Q L D+L + +++A E W++EK ++ + GKD +
Sbjct: 822 EAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDV 881
Query: 379 EALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSD 498
E + + + ++ A S + + A E P SD
Sbjct: 882 EIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSD 921
Score = 62.8 bits (151), Expect = 1e-09
Identities = 36/130 (27%), Positives = 68/130 (52%), Gaps = 1/130 (0%)
Frame = +1
Query: 40 GRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD-IEKKIDDMKNL 216
G+D I QNL+KKH+ ++ V + I ++ E + G+ ++ D + K + L
Sbjct: 1622 GKDEISAQNLMKKHENLEQSVEDYANTIRQL-GEVARQFSGDDISSGDAVAVKQSQLDKL 1680
Query: 217 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 396
++ LK+ A +RR L+++L+ + + E W+ ++E + GS E G+D D L ++
Sbjct: 1681 YAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSER 1740
Query: 397 HDALMADIEA 426
+ D EA
Sbjct: 1741 FNEFARDTEA 1750
Score = 60.5 bits (145), Expect = 6e-09
Identities = 46/168 (27%), Positives = 77/168 (45%), Gaps = 2/168 (1%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQ--AIQAEVTGHEPRILEVCNEGQKMIDGNHYA 174
I ++E +AGS +G+D V L ++ A E G E R+ +V +I H
Sbjct: 1715 ITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGE-RVAKVNGIADNLIQAGHSD 1773
Query: 175 NRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTE 354
+ I + D++ W DL + R Q+L S E ++ D + + EK+ V S E
Sbjct: 1774 SATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGV-SDE 1832
Query: 355 FGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSD 498
G+D S L +KH + D+ S + + Q ++ K+Q+A D
Sbjct: 1833 LGRDAGSVSTLQRKHYNFLQDLITLYSQVQQI--QEESAKLQDAYAGD 1878
Score = 54.7 bits (130), Expect = 3e-07
Identities = 63/268 (23%), Positives = 108/268 (40%), Gaps = 49/268 (18%)
Frame = +1
Query: 190 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLAD--------ASEAESWMREKEPLVG 345
K I D+ W L+ +R L + L Q+ L AS E+W+ E + LV
Sbjct: 383 KMISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVS 442
Query: 346 STEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSD----SYGKE 513
FG D + EA KKH+A+ DI AY + ++ D +++ D K+
Sbjct: 443 QDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCD--ELESERYHDVKRILLRKD 500
Query: 514 TVMALYDYQEKNpreVSMRK----------GDVLTLLNSNHKDWWKVEINDRQGHVPAA- 660
VM L+ Y + R MR ++L +L++ + + +D H+
Sbjct: 501 NVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVE 560
Query: 661 -YVKKVDAMMSDID-------------------------PNAPEQITVASQQKNLENQYE 762
++K + +DI+ P PE + S+ + LE+ Y
Sbjct: 561 DLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPE--IIVSRVQQLEDAYA 618
Query: 763 NLLSLGKDRRDRLKDSVQAYQLVREAND 846
L+ L +RR RL++S + +Q + D
Sbjct: 619 ELVRLAVERRSRLEESRKLWQFYWDTAD 646
Score = 48.9 bits (115), Expect = 2e-05
Identities = 30/157 (19%), Positives = 73/157 (46%), Gaps = 1/157 (0%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK + + G+D+ V+ + + + E+ + R+ V ++++ H +
Sbjct: 862 IKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSD 921
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTE-F 357
+I ++ + + WS L+ KA+ + L + Q + + E SW+ +K+ ++ T+
Sbjct: 922 EILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSL 981
Query: 358 GKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADA 468
D L ++ + D+ A ++ + SL +A++
Sbjct: 982 EMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANS 1018
Score = 48.9 bits (115), Expect = 2e-05
Identities = 51/315 (16%), Positives = 120/315 (38%), Gaps = 33/315 (10%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ ++E + +L +N +K+H+A + ++ +I + +++ +H+
Sbjct: 1185 LSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDAD 1244
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I K+ +++ D + +A + + L + ++ ++L D E W++EK E
Sbjct: 1245 KIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKY-ATSQDESY 1303
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSD-------------- 498
+ + + +H A A+I A + + A ++ D
Sbjct: 1304 RSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFD 1363
Query: 499 ---SYGKETVMALYDYQEK--------------NpreVSMRKGDVLTLLNSNHKDWWKVE 627
+ KE L+D + E + GD L S + K +
Sbjct: 1364 DLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQ 1423
Query: 628 INDRQGHVPAAYVKKVDAMMSDIDPNAPEQ--ITVASQQKNLENQYENLLSLGKDRRDRL 801
+ Q V A V+++D + PE+ + ++ + ++E + + +R+ L
Sbjct: 1424 VIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKAL 1483
Query: 802 KDSVQAYQLVREAND 846
+ +A+Q R+ D
Sbjct: 1484 EKKKEAFQFCRDVED 1498
Score = 47.0 bits (110), Expect = 7e-05
Identities = 28/144 (19%), Positives = 67/144 (46%), Gaps = 1/144 (0%)
Frame = +1
Query: 1 IHEKEPIAGSTN-VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYAN 177
I +K+ I T+ + DL GV L ++ + ++ + ++ + E + D +
Sbjct: 968 IEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEA 1027
Query: 178 RDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEF 357
+ I ++I ++ +W L +R L+++ + ++L D ++W+ + + V S +
Sbjct: 1028 KIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDT 1087
Query: 358 GKDEDSTEALLKKHDALMADIEAY 429
E LL +H ++ +I+ Y
Sbjct: 1088 PTSLPEAEKLLNQHQSIREEIDNY 1111
Score = 46.2 bits (108), Expect = 1e-04
Identities = 31/135 (22%), Positives = 62/135 (45%), Gaps = 3/135 (2%)
Frame = +1
Query: 28 STNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYAN---RDIEKKI 198
S +GRD V L +KH ++ ++ ++ E K+ D YA ++I +
Sbjct: 1830 SDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDA--YAGDKAKEITNRE 1887
Query: 199 DDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDST 378
++ + W +L+ D R+Q L D+ + ++ WM + + ++E +D
Sbjct: 1888 QEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGV 1947
Query: 379 EALLKKHDALMADIE 423
E L+ H +L A+I+
Sbjct: 1948 ELLMNNHQSLKAEID 1962
Score = 32.0 bits (71), Expect = 2.2
Identities = 30/143 (20%), Positives = 61/143 (42%)
Frame = +1
Query: 10 KEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIE 189
+EP S+ +G + V+NLIKKH+A + E R + R
Sbjct: 2037 QEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSAL--------------ERLTT 2082
Query: 190 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE 369
++ +MK +L +A+++R + +A A+ ++ E+ R+ + VG++ +
Sbjct: 2083 FELKEMKRR-QELAEEAERQRIKEEQEAKAASEAAEQAKREAERRD-DVDVGASHDDSER 2140
Query: 370 DSTEALLKKHDALMADIEAYRST 438
T + H+ + + ST
Sbjct: 2141 GGTPGAGEGHEGYVTRKHEWDST 2163
>sp|P16546|SPTA2_MOUSE Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 1458
Score = 117 bits (294), Expect = 3e-26
Identities = 58/152 (38%), Positives = 91/152 (59%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK+ + S + GRDL GVQNL KKH+ ++AE+ HEP I V + G+K+ D N
Sbjct: 766 IKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQE 825
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I++++ W +LK A R Q L++SLE QQ++A+ E E+W+ EK LV S ++G
Sbjct: 826 EIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG 885
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRT 456
+ + LLKKH+A D ++ ++ + T
Sbjct: 886 DTLAAIQGLLKKHEAFETDFTVHKDRVNDVCT 917
Score = 98.2 bits (243), Expect = 3e-20
Identities = 45/150 (30%), Positives = 85/150 (56%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E E + S + G+DL V NL+KKHQ ++A+++ HE R+ ++ ++ ++ + +
Sbjct: 660 LSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTS 719
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+++K D + + +K+ A RR L +S Q+ D + ESW++EK+ LV S ++G
Sbjct: 720 QVKEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYG 779
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL 450
+D + L KKH L A++ A+ I +
Sbjct: 780 RDLTGVQNLRKKHKRLEAELAAHEPAIQGV 809
Score = 94.4 bits (233), Expect = 4e-19
Identities = 47/88 (53%), Positives = 63/88 (71%), Gaps = 1/88 (1%)
Frame = +1
Query: 589 LLNSNHKDWWKVEINDRQGHVPAAYVKKVDAMMSDIDPN-APEQITVASQQKNLENQYEN 765
LLNS +KDWWKVE+NDRQG VPAAYVKK+D S N EQ ++A +Q ++NQY++
Sbjct: 2 LLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQGQIDNQYQS 61
Query: 766 LLSLGKDRRDRLKDSVQAYQLVREANDL 849
LL LG+ R+ L+ S + + L REAN+L
Sbjct: 62 LLELGEKRKGMLEKSCKKFMLFREANEL 89
Score = 94.0 bits (232), Expect = 5e-19
Identities = 71/258 (27%), Positives = 122/258 (47%), Gaps = 8/258 (3%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I+EK + S + G L +Q L+KKH+A + + T H+ R+ +VC GQ +I N++
Sbjct: 872 INEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE 931
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+I K+ + SDL+ A +R+ LD++ Q+ A ESW+ EKE + + ++G
Sbjct: 932 NISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYG 991
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 540
+D S + LL K + A ++A++ QE + + K+ ++A Q
Sbjct: 992 RDLSSVQTLLTKQETFDAGLQAFQ---------------QEGIANITALKDQLLAAKHIQ 1036
Query: 541 EK--NpreVSMRKGDVLTLLNSNHKDWWKVEINDRQGH------VPAAYVKKVDAMMSDI 696
K R S+ K L NS + K ++ + Q H + + KK A S
Sbjct: 1037 SKAIEARHASLMKRWTQLLANSATR---KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWF 1093
Query: 697 DPNAPEQITVASQQKNLE 750
+ NA E +T + +LE
Sbjct: 1094 E-NAEEDLTDPVRCNSLE 1110
Score = 84.3 bits (207), Expect = 4e-16
Identities = 43/149 (28%), Positives = 76/149 (51%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EK + N G DL VQ L +KH+ + ++ ++ + Q++I + +
Sbjct: 235 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAE 294
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
D+++K ++ W+ L +AD+R+ L DS + Q++L+D + SW+ LV S E
Sbjct: 295 DLKEKCTELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 354
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDS 447
KD EALL++H +I+A T +
Sbjct: 355 KDVTGAEALLERHQEHRTEIDARAGTFQA 383
Score = 83.2 bits (204), Expect = 8e-16
Identities = 44/149 (29%), Positives = 78/149 (52%)
Frame = +1
Query: 19 IAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKI 198
+ S + +D+ G + L+++HQ + E+ GQ+++ HYA+ +I++K+
Sbjct: 347 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKEKL 406
Query: 199 DDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDST 378
D + +DL+ +RR +LD LE Q + D +AE+WM +E + + + G DS
Sbjct: 407 DILDQERTDLEKAWVQRRMMLDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 466
Query: 379 EALLKKHDALMADIEAYRSTIDSLRTQAD 465
EAL+KKH+ I I +L+ AD
Sbjct: 467 EALIKKHEDFDKAINVQEEKIAALQAFAD 495
Score = 77.8 bits (190), Expect = 4e-14
Identities = 44/150 (29%), Positives = 78/150 (52%), Gaps = 2/150 (1%)
Frame = +1
Query: 43 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD--IEKKIDDMKNL 216
+D +Q+ +KHQA +AE+ + RI V + G +I+ A + ++ ++ + +
Sbjct: 566 KDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQ 625
Query: 217 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 396
W L K+ ++ Q L ++ + Q + + + W+ E E L+ S ++GKD S LLKK
Sbjct: 626 WQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKK 685
Query: 397 HDALMADIEAYRSTIDSLRTQADACKMQEA 486
H L ADI A+ + L +QAD+ A
Sbjct: 686 HQLLEADISAHEDRLKDLNSQADSLMTSSA 715
Score = 71.6 bits (174), Expect = 3e-12
Identities = 71/313 (22%), Positives = 133/313 (42%), Gaps = 34/313 (10%)
Frame = +1
Query: 10 KEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIE 189
+E + + G L V+ LIKKH+ + E +I + ++I +HYA DI
Sbjct: 450 REAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAVDHYAKGDIA 509
Query: 190 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE 369
+ +++ + W LK + ++R L +S QQ+ D E E+W+ EK S E KD
Sbjct: 510 NRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ-TASDESYKDP 568
Query: 370 DSTEALLKKHDALMADIEA----YRSTID---------SLRTQADACKMQEAPVSDSY-- 504
+ ++ +KH A A++ A R ID + DA K + A ++D +
Sbjct: 569 TNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQF 628
Query: 505 ----GKETVMALYDYQEKNpreVSMRKGD-----VLTLLNSNH--KDWWKVEINDRQGHV 651
E L + ++ ++ D V LL S KD V ++ +
Sbjct: 629 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQL 688
Query: 652 PAAYVKKVDAMMSDIDPNAPEQIT--------VASQQKNLENQYENLLSLGKDRRDRLKD 807
A + + + D++ A +T V ++ + +++ + S+ RR +L +
Sbjct: 689 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSE 748
Query: 808 SVQAYQLVREAND 846
S + +Q R+ +D
Sbjct: 749 SHRLHQFFRDMDD 761
Score = 60.1 bits (144), Expect = 8e-09
Identities = 43/187 (22%), Positives = 77/187 (41%), Gaps = 37/187 (19%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKE + VG DL V+ L KK Q ++ +E R+ ++ N+ + ++
Sbjct: 93 ITEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDI-NKVAEDLESEGLMAE 151
Query: 181 DIE-------------------------------------KKIDDMKNLWSDLKNKADKR 249
+++ I ++ W L+ A++R
Sbjct: 152 EVQAVQQQEVYGAMPRDEADSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEER 211
Query: 250 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 429
QLL + E Q++ DA E + W+ EK + + +G D S +AL +KH+ D+ A
Sbjct: 212 SQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAAL 271
Query: 430 RSTIDSL 450
++SL
Sbjct: 272 GDKVNSL 278
Score = 47.8 bits (112), Expect = 4e-05
Identities = 24/85 (28%), Positives = 42/85 (49%)
Frame = +1
Query: 211 NLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALL 390
N + L +KR+ +L+ S + +A+E + W+ EKE + + E G D + E L
Sbjct: 57 NQYQSLLELGEKRKGMLEKSCKKFMLFREANELQQWITEKEAALTNEEVGADLEQVEVLQ 116
Query: 391 KKHDALMADIEAYRSTIDSLRTQAD 465
KK D D++A S + + A+
Sbjct: 117 KKFDDFQKDLKANESRLKDINKVAE 141
>sp|Q01082|SPTB2_HUMAN Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1)
(Beta-II spectrin) (Fodrin beta chain)
Length = 2364
Score = 116 bits (291), Expect = 7e-26
Identities = 63/167 (37%), Positives = 98/167 (58%), Gaps = 1/167 (0%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI-DGNHYAN 177
+ E+ P+A ST+ G +L VQ LIKK+Q +Q E+ GH+PRI ++ Q ++ D + +
Sbjct: 1501 VGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1560
Query: 178 RDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEF 357
I +++ D+K LW L + +KR + L+++ AQQY DA+EAE+WM E+E + S E
Sbjct: 1561 EAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEK 1620
Query: 358 GKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSD 498
KDE S ++LKKH L +E Y T+ L + A P S+
Sbjct: 1621 AKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESE 1667
Score = 110 bits (276), Expect = 4e-24
Identities = 56/170 (32%), Positives = 97/170 (57%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKE I S + G+DL V L+ KH+A + E++G + EG+ MI H+ +
Sbjct: 654 IREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSE 713
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I ++I ++ W++L+ + R++ L+++ Q+ ADA + ++WM + +V S++ G
Sbjct: 714 KIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVG 773
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGK 510
DE ST++L+KKH + +I YR T+D+L QA A + A D G+
Sbjct: 774 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGR 823
Score = 75.1 bits (183), Expect = 2e-13
Identities = 38/121 (31%), Positives = 66/121 (54%)
Frame = +1
Query: 43 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWS 222
RD+ V+ L+ HQ I+AE+ G+ ++ HYA+ +I++K+ +
Sbjct: 1941 RDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRK 2000
Query: 223 DLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHD 402
++ +K + R + L LE Q+ DAS AE+W+ +EP + S E G+ D E L+K+H+
Sbjct: 2001 EMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHE 2060
Query: 403 A 405
A
Sbjct: 2061 A 2061
Score = 73.9 bits (180), Expect = 5e-13
Identities = 73/319 (22%), Positives = 138/319 (43%), Gaps = 40/319 (12%)
Frame = +1
Query: 7 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI-DGNHYANRD 183
E + + S + G+ L+GV++L++KH ++A++ R+ V QK DG Y D
Sbjct: 546 EMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCD 605
Query: 184 ---IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTE 354
I ++ M+ + +L A +RR L++S ++ + +E E W+REKE ++ S +
Sbjct: 606 PQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDD 665
Query: 355 FGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYD 534
+GKD S LL KH A ++ + + ++ + +G E +
Sbjct: 666 YGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG-----EDMIAEEHFGSEKIRERII 720
Query: 535 Y---QEKNpreVSMRKGDVLTLLNSNHK--------DWWKVEI-----NDRQGH---VPA 657
Y Q N ++S + L + H+ D W ++I + GH
Sbjct: 721 YIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQ 780
Query: 658 AYVKKVDAMMSDIDPNAP------EQITVASQQ-----------KNLENQYENLLSLGKD 786
+ VKK + +I P EQ + Q+ +E +Y+ + L +
Sbjct: 781 SLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL 840
Query: 787 RRDRLKDSVQAYQLVREAN 843
R+ L+D++ Y++ EA+
Sbjct: 841 RKQALQDTLALYKMFSEAD 859
Score = 69.7 bits (169), Expect = 1e-11
Identities = 42/140 (30%), Positives = 70/140 (50%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E + + N G DL V+ KKH+AI+ ++ +E R+ V +++ N++ +
Sbjct: 438 LSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIK 497
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I + D++ LW L RRQ L+ +L Q+ + WM E + LV S ++G
Sbjct: 498 RITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYG 557
Query: 361 KDEDSTEALLKKHDALMADI 420
K E LL+KH + ADI
Sbjct: 558 KHLLGVEDLLQKHTLVEADI 577
Score = 67.8 bits (164), Expect = 4e-11
Identities = 69/319 (21%), Positives = 141/319 (44%), Gaps = 36/319 (11%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+H E S + G+ L V L+KK Q ++ ++ + I E+ ++ Q + +
Sbjct: 1396 LHGLESQIQSDDYGKHLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTD- 1454
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
+++ K ++ + +L ++R+ L S E Q+ D + W+ E+ PL ST+ G
Sbjct: 1455 EVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHG 1514
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSL--RTQ----------ADACKMQEAPVSDSY 504
+ + + L+KK+ L +I+ ++ ID + R+Q A+A + + A + +
Sbjct: 1515 HNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLW 1574
Query: 505 G-------------KETVMALYDYQEKNpreVSMRKGDVLTLLNSNHKDWW-------KV 624
G +E A Y + E M + ++ + KD K
Sbjct: 1575 GLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKH 1634
Query: 625 EINDRQGHVPAAYVKKVD----AMMSDIDPNAPEQITVASQQKNLENQYENLLSLGKDRR 792
+I ++ A V ++ A+++D + PE ++ +Q ++ Y L L ++RR
Sbjct: 1635 QILEQAVEDYAETVHQLSKTSRALVAD---SHPESERISMRQSKVDKLYAGLKDLAEERR 1691
Query: 793 DRLKDSVQAYQLVREANDL 849
+L + + +QL RE +DL
Sbjct: 1692 GKLDERHRLFQLNREVDDL 1710
Score = 67.4 bits (163), Expect = 5e-11
Identities = 57/271 (21%), Positives = 116/271 (42%), Gaps = 14/271 (5%)
Frame = +1
Query: 76 KHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQ 255
KHQA AE+ ++ + ++ EG ++I +++K+ + +W L++ + Q
Sbjct: 1315 KHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ 1374
Query: 256 LLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRS 435
L D+ +A+ + ++ + W+ E + S ++GK S LLKK L +E +
Sbjct: 1375 RLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKHLTSVNILLKKQQMLENQMEVRKK 1434
Query: 436 TIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQE----KNpreVSMRKGDVLTLLNSN 603
I+ L++QA A QE +D + + + E N R+ ++ + N +
Sbjct: 1435 EIEELQSQAQALS-QEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRD 1493
Query: 604 HKD---W----WKVEINDRQGH---VPAAYVKKVDAMMSDIDPNAPEQITVASQQKNLEN 753
+D W + + GH +KK + +I + P + + +N+
Sbjct: 1494 VEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVT 1553
Query: 754 QYENLLSLGKDRRDRLKDSVQAYQLVREAND 846
+L + + R RL D Q + L+ E +
Sbjct: 1554 DSSSLSA--EAIRQRLADLKQLWGLLIEETE 1582
Score = 65.9 bits (159), Expect = 1e-10
Identities = 35/156 (22%), Positives = 77/156 (49%), Gaps = 1/156 (0%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKE + + L ++ + + ++++ E+ R+ V ++++ H + +
Sbjct: 865 IDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEK 924
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGST-EF 357
+I+ + D + WS + D+++ L +L Q Y + +E +SW+REK ++ ST +
Sbjct: 925 EIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDL 984
Query: 358 GKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQAD 465
G D AL +K + D+ A + + L+ +A+
Sbjct: 985 GNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAE 1020
Score = 65.5 bits (158), Expect = 2e-10
Identities = 36/177 (20%), Positives = 82/177 (46%), Gaps = 1/177 (0%)
Frame = +1
Query: 1 IHEKEPIAGST-NVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYAN 177
I EK + ST ++G DL GV L +K ++ ++ E ++ ++ E +K+ +
Sbjct: 971 IREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQA 1030
Query: 178 RDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEF 357
+ I ++ ++ ++W ++K R L ++ + QQ+L D + +SW+ + + S +
Sbjct: 1031 QAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDM 1090
Query: 358 GKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMAL 528
E LL +H+ + +I+ Y +R + + + ++ + AL
Sbjct: 1091 PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQAL 1147
Score = 63.2 bits (152), Expect = 9e-10
Identities = 48/168 (28%), Positives = 82/168 (48%), Gaps = 2/168 (1%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGH--EPRILEVCNEGQKMIDGNHYA 174
I E+E +AGS +G+D V L ++ + A TG+ + R+ V + ++I+ H
Sbjct: 1714 IAEREVVAGSHELGQDYEHVTMLQERFREF-ARDTGNIGQERVDTVNHLADELINSGHSD 1772
Query: 175 NRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTE 354
I + D + W+DL D R Q+L S E ++ DA E +++K + E
Sbjct: 1773 AATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-E 1831
Query: 355 FGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSD 498
G+D+++ E L + H DI+A + + L Q DA ++Q A D
Sbjct: 1832 LGRDQNTVETLQRMHTTFEHDIQALGTQVRQL--QEDAARLQAAYAGD 1877
Score = 59.3 bits (142), Expect = 1e-08
Identities = 30/141 (21%), Positives = 68/141 (48%)
Frame = +1
Query: 19 IAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKI 198
I S++VG D Q+L+KKH+ + E+ + P L+ +E + H + D+ ++
Sbjct: 766 IVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPT-LDTLHEQASALPQEHAESPDVRGRL 824
Query: 199 DDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDST 378
++ + ++ R+Q L D+L + ++A E W+ EKE + + + + +
Sbjct: 825 SGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDL 884
Query: 379 EALLKKHDALMADIEAYRSTI 441
E + + ++L ++ S +
Sbjct: 885 EVIQHRFESLEPEMNNQASRV 905
Score = 57.8 bits (138), Expect = 4e-08
Identities = 38/180 (21%), Positives = 85/180 (47%), Gaps = 1/180 (0%)
Frame = +1
Query: 28 STNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYAN-RDIEKKIDD 204
S ++ L + L+ +H+ I+ E+ +E ++ + G+ + G A + +++
Sbjct: 1087 SEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQA 1146
Query: 205 MKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEA 384
+ W++L + R+ LL S QQ+L D +AE+++ +E ++ TE + EA
Sbjct: 1147 LDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEA 1206
Query: 385 LLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQEKNpreVS 564
+KK + M ++A I+++ + + + ++ +E V ++ D KN S
Sbjct: 1207 AIKKQEDFMTTMDANEEKINAV-VETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETAS 1265
Score = 55.1 bits (131), Expect = 2e-07
Identities = 30/130 (23%), Positives = 63/130 (48%)
Frame = +1
Query: 7 EKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDI 186
E+E S +D +++KKHQ ++ V + + ++ + ++ +H + I
Sbjct: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
Query: 187 EKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKD 366
+ + L++ LK+ A++RR LD+ Q + + E W+ E+E + GS E G+D
Sbjct: 1670 SMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQD 1729
Query: 367 EDSTEALLKK 396
+ L ++
Sbjct: 1730 YEHVTMLQER 1739
Score = 50.1 bits (118), Expect = 8e-06
Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 8/95 (8%)
Frame = +1
Query: 190 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLAD--------ASEAESWMREKEPLVG 345
K I D+ W L+ +R L + L Q+ L A+ E+W+ E + LV
Sbjct: 387 KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVS 446
Query: 346 STEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 450
FG D + EA KKH+A+ DI AY + ++
Sbjct: 447 QDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAV 481
>sp|Q62261|SPTB2_MOUSE Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1)
(Beta-II spectrin) (Fodrin beta chain)
Length = 2363
Score = 108 bits (269), Expect = 2e-23
Identities = 57/170 (33%), Positives = 94/170 (55%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKE I S + G+DL V L+ KH+A + E++G + EG+ MI H+ +
Sbjct: 654 IREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSE 713
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I ++I ++ W++L+ + R + L+++ Q+ ADA + ++WM + +V S + G
Sbjct: 714 KIRERIIYIREQWANLEQLSAIRIKRLEEASLLHQFQADADDIDAWMLDILKIVSSNDVG 773
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGK 510
DE ST++L+KKH + +I YR TID+L QA A A D G+
Sbjct: 774 HDEYSTQSLVKKHKDVAEEITNYRPTIDTLHEQASALPQAHAESPDVKGR 823
Score = 107 bits (266), Expect = 5e-23
Identities = 59/167 (35%), Positives = 97/167 (58%), Gaps = 1/167 (0%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E+ P+ ST+ G +L VQ LIKK+Q +Q E+ GH+PRI ++ Q +I + N
Sbjct: 1501 VGERMPLRTSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIITDSSSLNA 1560
Query: 181 D-IEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEF 357
+ I +++ D+K LW L + +KR + L+++ +AQQY DA+EAE+WM E+E + S +
Sbjct: 1561 EAIRQRLADLKQLWGLLIEETEKRHRRLEEAHKAQQYYFDAAEAEAWMSEQELYMMSEKR 1620
Query: 358 GKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSD 498
+ + S ++LKKH L +E Y T+ L + A P S+
Sbjct: 1621 PRMKQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESE 1667
Score = 75.1 bits (183), Expect = 2e-13
Identities = 38/121 (31%), Positives = 66/121 (54%)
Frame = +1
Query: 43 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWS 222
RD+ V+ L+ HQ I+AE+ G+ ++ HYA+ +I++K+ +
Sbjct: 1941 RDVSSVELLMNNHQGIKAEIDARNDSFTACIELGKSLLARKHYASEEIKEKLLQLTEKRK 2000
Query: 223 DLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHD 402
++ +K + R + L LE Q+ DAS AE+W+ +EP + S E G+ D E L+K+H+
Sbjct: 2001 EMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHE 2060
Query: 403 A 405
A
Sbjct: 2061 A 2061
Score = 72.4 bits (176), Expect = 1e-12
Identities = 42/130 (32%), Positives = 71/130 (54%), Gaps = 4/130 (3%)
Frame = +1
Query: 28 STNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI-DGNHYANRD---IEKK 195
S + G+ L+GV++L++KH ++A++ R+ V QK DG Y D I +
Sbjct: 553 SQDYGKHLLGVEDLLQKHALVEADIAIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDR 612
Query: 196 IDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDS 375
+ M+ + +L A +RR L++S ++ + +E E W+REKE ++ S ++GKD S
Sbjct: 613 VAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS 672
Query: 376 TEALLKKHDA 405
LL KH A
Sbjct: 673 VMRLLSKHRA 682
Score = 68.6 bits (166), Expect = 2e-11
Identities = 42/154 (27%), Positives = 73/154 (47%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
+ E + + N G DL V+ KKH+AI+ ++ +E R+ V +++ N++ +
Sbjct: 438 LSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIK 497
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 360
I + D++ LW L RRQ L+ +L Q+ + WM E + L+ S ++G
Sbjct: 498 RITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLLLSQDYG 557
Query: 361 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQA 462
K E LL+KH + ADI + + A
Sbjct: 558 KHLLGVEDLLQKHALVEADIAIQAERVRGVNASA 591
Score = 65.5 bits (158), Expect = 2e-10
Identities = 35/156 (22%), Positives = 76/156 (48%), Gaps = 1/156 (0%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANR 180
I EKE + + L ++ + + ++++ E+ R+ V ++++ H + +
Sbjct: 865 IDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHNGHPSEK 924
Query: 181 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGST-EF 357
+I + D + WS + D+++ L +L Q Y + +E +SW+REK ++ ST +
Sbjct: 925 EIRAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDL 984
Query: 358 GKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQAD 465
G D AL +K + D+ A + + L+ +A+
Sbjct: 985 GNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAE 1020
Score = 65.5 bits (158), Expect = 2e-10
Identities = 36/177 (20%), Positives = 82/177 (46%), Gaps = 1/177 (0%)
Frame = +1
Query: 1 IHEKEPIAGST-NVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYAN 177
I EK + ST ++G DL GV L +K ++ ++ E ++ ++ E +K+ +
Sbjct: 971 IREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQA 1030
Query: 178 RDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEF 357
+ I ++ ++ ++W ++K R L ++ + QQ+L D + +SW+ + + S +
Sbjct: 1031 QAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDM 1090
Query: 358 GKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMAL 528
E LL +H+ + +I+ Y +R + + + ++ + AL
Sbjct: 1091 PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQAL 1147
Score = 65.5 bits (158), Expect = 2e-10
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 2/168 (1%)
Frame = +1
Query: 1 IHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGH--EPRILEVCNEGQKMIDGNHYA 174
I E+E +AGS +G+D V L ++ + A TG+ + R+ V N ++I+ H
Sbjct: 1714 IAEREVVAGSHELGQDYEHVTMLQERFREF-ARDTGNIGQERVDTVNNMADELINSGHSD 1772
Query: 175 NRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTE 354
I + D + W+DL D R Q+L S E ++ DA E +++K + E
Sbjct: 1773 AATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE-E 1831
Query: 355 FGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSD 498
G+D+++ E L + H DI+A + + L Q DA ++Q A D
Sbjct: 1832 LGRDQNTVETLQRMHTTFEHDIQALGTQVRQL--QEDAARLQAAYAGD 1877
Score = 57.8 bits (138), Expect = 4e-08
Identities = 31/141 (21%), Positives = 68/141 (48%)
Frame = +1
Query: 19 IAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKI 198
I S +VG D Q+L+KKH+ + E+T + P I + +E + H + D++ ++
Sbjct: 766 IVSSNDVGHDEYSTQSLVKKHKDVAEEITNYRPTI-DTLHEQASALPQAHAESPDVKGRL 824
Query: 199 DDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDST 378
++ ++ R+Q L D+L + ++A E W+ EKE + + + + +
Sbjct: 825 AGIEERCKEMAELTRLRKQALRDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDL 884
Query: 379 EALLKKHDALMADIEAYRSTI 441
E + + ++L ++ S +
Sbjct: 885 EVIQHRFESLEPEMNNQASRV 905
Score = 57.8 bits (138), Expect = 4e-08
Identities = 38/180 (21%), Positives = 85/180 (47%), Gaps = 1/180 (0%)
Frame = +1
Query: 28 STNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYAN-RDIEKKIDD 204
S ++ L + L+ +H+ I+ E+ +E ++ + G+ + G A + +++
Sbjct: 1087 SEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQA 1146
Query: 205 MKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEA 384
+ W++L + R+ LL S QQ+L D +AE+++ +E ++ TE + EA
Sbjct: 1147 LDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEA 1206
Query: 385 LLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQEKNpreVS 564
+KK + M ++A I+++ + + + ++ +E V ++ D KN S
Sbjct: 1207 AIKKQEDFMTTMDANEEKINAV-VETGRRLVSDGNINSDRIQEKVDSIDDRHRKNREAAS 1265
Score = 55.1 bits (131), Expect = 2e-07
Identities = 30/135 (22%), Positives = 65/135 (48%), Gaps = 1/135 (0%)
Frame = +1
Query: 64 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 243
+++KKHQ ++ V + + ++ + ++ +H + I + + L++ LK+ A+
Sbjct: 1629 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAE 1688
Query: 244 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI- 420
+RR LD+ Q + + E W+ E+E + GS E G+D + L ++ D
Sbjct: 1689 ERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTG 1748
Query: 421 EAYRSTIDSLRTQAD 465
+ +D++ AD
Sbjct: 1749 NIGQERVDTVNNMAD 1763
Score = 51.6 bits (122), Expect = 3e-06
Identities = 57/269 (21%), Positives = 107/269 (39%), Gaps = 43/269 (15%)
Frame = +1
Query: 172 ANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGST 351
A ++ K ++ + +L +R+ L S E Q+ D + W+ E+ PL ST
Sbjct: 1452 AQMRVDSKRLTVQTKFMELLEPLSERKHNLLASKEIHQFNRDVEDEILWVGERMPLRTST 1511
Query: 352 EFGKDEDSTEALLKKHDALMADIEAYRSTIDSL--------------------------- 450
+ G + + + L+KK+ L +I+ ++ ID +
Sbjct: 1512 DHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIITDSSSLNAEAIRQRLADLK 1571
Query: 451 --------RTQADACKMQEAPVSDSYGKETVMA--------LYDYQEKNpreVSMRKGDV 582
T+ +++EA + Y + A LY EK PR K
Sbjct: 1572 QLWGLLIEETEKRHRRLEEAHKAQQYYFDAAEAEAWMSEQELYMMSEKRPR----MKQSA 1627
Query: 583 LTLLNSNHKDWWKVEINDRQGHVPAAYVKKVDAMMSDIDPNAPEQITVASQQKNLENQYE 762
+++L + VE H + K A+++D + PE ++ +Q ++ Y
Sbjct: 1628 VSMLKKHQILEQAVEDYAETVHQLS---KTSRALVAD---SHPESERISMRQSKVDKLYA 1681
Query: 763 NLLSLGKDRRDRLKDSVQAYQLVREANDL 849
L L ++RR +L + + +QL RE +DL
Sbjct: 1682 GLKDLAEERRGKLDERHRLFQLNREVDDL 1710
Score = 50.1 bits (118), Expect = 8e-06
Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 8/95 (8%)
Frame = +1
Query: 190 KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLAD--------ASEAESWMREKEPLVG 345
K I D+ W L+ +R L + L Q+ L A+ E+W+ E + LV
Sbjct: 387 KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVS 446
Query: 346 STEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 450
FG D + EA KKH+A+ DI AY + ++
Sbjct: 447 QDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAV 481
Score = 45.8 bits (107), Expect = 1e-04
Identities = 23/98 (23%), Positives = 50/98 (51%), Gaps = 1/98 (1%)
Frame = +1
Query: 76 KHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQ 255
KHQA AE+ ++ + ++ EG ++I +++K+ + +W L++ + Q
Sbjct: 1315 KHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ 1374
Query: 256 LLDDSLEAQQYLADASEAESWMREKE-PLVGSTEFGKD 366
L D+ +A+ + ++ + W+ E P S ++GKD
Sbjct: 1375 RLFDANKAELFTQSCADLDKWLHGLEKPGFQSDDYGKD 1412
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.311 0.128 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,375,928
Number of Sequences: 369166
Number of extensions: 1530266
Number of successful extensions: 4967
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4271
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4836
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8390082510
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)