Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_K12
(867 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P22892|AP1G1_MOUSE Adapter-related protein complex 1 gam... 128 2e-29
sp|O43747|AP1G1_HUMAN Adapter-related protein complex 1 gam... 126 7e-29
sp|O88512|AP1G2_MOUSE Adapter-related protein complex 1 gam... 92 1e-18
sp|O75843|AP1G2_HUMAN Adapter-related protein complex 1 gam... 85 2e-16
sp|Q9NZ52|GGA3_HUMAN ADP-ribosylation factor binding protei... 55 3e-07
sp|P38817|GGA2_YEAST ADP-ribosylation factor binding protei... 54 7e-07
sp|Q8R0H9|GGA1_MOUSE ADP-ribosylation factor binding protei... 53 1e-06
sp|Q99128|ADG_USTMA Gamma-adaptin (Golgi adaptor HA1/AP1 ad... 53 1e-06
sp|Q9UJY5|GGA1_HUMAN ADP-ribosylation factor binding protei... 53 1e-06
sp|Q8BMI3|GGA3_MOUSE ADP-ribosylation factor binding protei... 51 4e-06
>sp|P22892|AP1G1_MOUSE Adapter-related protein complex 1 gamma 1 subunit (Gamma-adaptin)
(Adaptor protein complex AP-1 gamma-1 subunit) (Golgi
adaptor HA1/AP1 adaptin gamma-1 subunit) (Clathrin
assembly protein complex 1 gamma-1 large chain)
Length = 822
Score = 128 bits (322), Expect = 2e-29
Identities = 98/284 (34%), Positives = 144/284 (50%), Gaps = 19/284 (6%)
Frame = +2
Query: 14 QQRSVEFSSIFRNYDNLRIGLLEAMPVMETRVLSGTLTGNNELTVTEKSNNMPGQLNGYG 193
QQR+VE++++F+ YD++R LLE MPVME T G +E+ T P L
Sbjct: 560 QQRAVEYNALFKKYDHMRSALLERMPVME----KVTTNGPSEIVQTNGETE-PAPLE--- 611
Query: 194 CEIISDVPEN---KTNNAGQLLDLLSLTD--PVSSTNNQSTDLNLNGTAISNNSTGNIFD 358
+ P + T+ A LLDLL D PV T S + G + D
Sbjct: 612 ----TKPPPSGPQPTSQANDLLDLLGGNDITPVIPTAPTSKPASAGG---------ELLD 658
Query: 359 LLGDLSLN---------SEMPPISNHK--APSTNATPQISDTKPAISSIIVYESSHGLKL 505
LLGD++L + +P IS ++ P +D P I SI Y S +GLK+
Sbjct: 659 LLGDITLTGAPAAAPTPASVPQISQPPFLLDGLSSQPLFNDIAPGIPSITAY-SKNGLKI 717
Query: 506 TFSFERISNSQST--VTLHAINNGNQLIDQFLFQAAVPKSFQLVLLAPSSDNLMPFG-GS 676
F+FER + + S +T+ A N+ + F+FQAAVPK+FQL LL+PSS + F G+
Sbjct: 718 EFTFERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSVVPAFNTGT 777
Query: 677 LTQLLKLSNPNKQPWKMKIRLQYRLNGEVKSVQHQLDTFPSDLW 808
+TQ++K+ NP KQ +M+I+L Y G +++ FP W
Sbjct: 778 ITQVIKVLNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQSW 821
>sp|O43747|AP1G1_HUMAN Adapter-related protein complex 1 gamma 1 subunit (Gamma-adaptin)
(Adaptor protein complex AP-1 gamma-1 subunit) (Golgi
adaptor HA1/AP1 adaptin gamma-1 subunit) (Clathrin
assembly protein complex 1 gamma-1 large chain)
Length = 822
Score = 126 bits (317), Expect = 7e-29
Identities = 97/284 (34%), Positives = 146/284 (51%), Gaps = 19/284 (6%)
Frame = +2
Query: 14 QQRSVEFSSIFRNYDNLRIGLLEAMPVMETRVLSGTLTGNNELTVTEKSNNMPGQLNGYG 193
QQR+VE++++F+ YD++R LLE MPVME T G E+ T P L
Sbjct: 560 QQRAVEYNALFKKYDHMRSALLERMPVME----KVTTNGPTEIVQTNGETE-PAPLE--- 611
Query: 194 CEIISDVPEN---KTNNAGQLLDLLSLTD--PVSSTNNQSTDLNLNGTAISNNSTGNIFD 358
+ P + T+ A LLDLL D PV T T+ +++ G + D
Sbjct: 612 ----TKPPPSGPQPTSQANDLLDLLGGNDITPVIPTAP---------TSKPSSAGGELLD 658
Query: 359 LLGDLSLN---------SEMPPIS--NHKAPSTNATPQISDTKPAISSIIVYESSHGLKL 505
LLGD++L + +P IS + ++ P +D I SI Y S +GLK+
Sbjct: 659 LLGDINLTGAPAAAPAPASVPQISQPHFLLDGLSSQPLFNDIAAGIPSITAY-SKNGLKI 717
Query: 506 TFSFERISNSQST--VTLHAINNGNQLIDQFLFQAAVPKSFQLVLLAPSSDNLMPFG-GS 676
F+FER + + S +T+ A N+ + F+FQAAVPK+FQL LL+PSS + F G+
Sbjct: 718 EFTFERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSIVPAFNTGT 777
Query: 677 LTQLLKLSNPNKQPWKMKIRLQYRLNGEVKSVQHQLDTFPSDLW 808
+TQ++K+ NP KQ +M+I+L Y G +++ FP W
Sbjct: 778 ITQVIKVLNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQSW 821
>sp|O88512|AP1G2_MOUSE Adapter-related protein complex 1 gamma 2 subunit (Gamma2-adaptin)
(Adaptor protein complex AP-1 gamma-2 subunit) (G2ad)
Length = 791
Score = 92.4 bits (228), Expect = 1e-18
Identities = 82/272 (30%), Positives = 126/272 (46%), Gaps = 7/272 (2%)
Frame = +2
Query: 14 QQRSVEFSSIFRNYDNLRIGLLEAMPVMETRVLSGTLTGNNELTVTEKSNNMPGQLNGYG 193
QQR+VE++++F+ YD++R +LE MP++E G+ + K Q
Sbjct: 561 QQRAVEYNTLFQKYDHMRAAILEKMPLVER--------GDPHV----KEGGKEKQTEAQP 608
Query: 194 CEIISDVPENKTNNAGQLLDLLSL----TDPVSSTNNQSTDLNLNGTAISNNSTGNIFDL 361
E+ + P A +LLDLL L ++P+SS + Q S G
Sbjct: 609 LEVTAPAPTEP--QATKLLDLLDLLGDTSEPLSSGHAQHLPPQ-------TPSPGEALIH 659
Query: 362 LGDLSLNSEMPPISNHKAPSTNATPQISDTKPAISSIIVYESSHGLKLTFSFERISNSQS 541
L DL P AP I S+ V+E GL+L SF R + +
Sbjct: 660 LLDLPCTPPPP------AP--------------IPSVRVFERE-GLQLDLSFMRPLETPA 698
Query: 542 T--VTLHAINNGNQLIDQFLFQAAVPKSFQLVLLAPSSDNLMPFGG-SLTQLLKLSNPNK 712
VT N+ + + F+ QAAVPKSFQL L APS + + GG +TQ+ ++ NPN+
Sbjct: 699 LLLVTATTTNSSKEDVTHFVCQAAVPKSFQLQLQAPSGNTIPAQGGLPITQVFRILNPNQ 758
Query: 713 QPWKMKIRLQYRLNGEVKSVQHQLDTFPSDLW 808
P ++K+RL Y +G+ ++D P + W
Sbjct: 759 APLRLKLRLTYNHSGQPVQEIFEVDNLPVETW 790
>sp|O75843|AP1G2_HUMAN Adapter-related protein complex 1 gamma 2 subunit (Gamma2-adaptin)
(Adaptor protein complex AP-1 gamma-2 subunit) (G2ad)
Length = 785
Score = 85.1 bits (209), Expect = 2e-16
Identities = 77/268 (28%), Positives = 118/268 (44%), Gaps = 3/268 (1%)
Frame = +2
Query: 14 QQRSVEFSSIFRNYDNLRIGLLEAMPVMETRVLSGTLTGNNELTVTEKSNNMPGQLNGYG 193
QQR+VE+ ++FR YD++R +LE MP++E + K + QL+
Sbjct: 561 QQRAVEYDTLFRKYDHMRAAILEKMPLVE--------RDGPQADEEAKESKEAAQLS--- 609
Query: 194 CEIISDVPENKTNNAGQLLDLLSLTDPVSSTNNQSTDLNLNGTAISNNSTGNIFDLLGDL 373
P A QLLDLL L D S L+ + G + LL
Sbjct: 610 ----EAAPVPTEPQASQLLDLLDLLDGASGDVQHPPHLD-------PSPGGALVHLL--- 655
Query: 374 SLNSEMPPISNHKAPSTNATPQISDTKPAISSIIVYESSHGLKLTFSFERISNSQS--TV 547
++P + AP I + V+E G++L SF R + + +
Sbjct: 656 ----DLPCVPPPPAP--------------IPDLKVFE-REGVQLNLSFIRPPENPALLLI 696
Query: 548 TLHAINNGNQLIDQFLFQAAVPKSFQLVLLAPSSDNLMPFGG-SLTQLLKLSNPNKQPWK 724
T+ A N + F+ QAAVPKS QL L APS + + GG +TQL ++ NPNK P +
Sbjct: 697 TITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGLPITQLFRILNPNKAPLR 756
Query: 725 MKIRLQYRLNGEVKSVQHQLDTFPSDLW 808
+K+RL Y + +++ P + W
Sbjct: 757 LKLRLTYDHFHQSVQEIFEVNNLPVESW 784
>sp|Q9NZ52|GGA3_HUMAN ADP-ribosylation factor binding protein GGA3 (Golgi-localized, gamma
ear-containing, ARF-binding protein 3)
Length = 723
Score = 55.1 bits (131), Expect = 3e-07
Identities = 39/162 (24%), Positives = 72/162 (44%), Gaps = 9/162 (5%)
Frame = +2
Query: 338 STGNIFDLLGDLSLNSEMPPISNHKAPSTNATPQISDTKPAISSIIVYESSHGLKLTFSF 517
STG L LS S+ P + + + KP+ + + +G ++ F F
Sbjct: 554 STGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHF 613
Query: 518 ERISNSQS----TVTLHAINNGNQLIDQFLFQAAVPKSFQLVLLAPSSDNLMPFG----- 670
+ V + +N + + QAAVPKS ++ L PS L PF
Sbjct: 614 AKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPP 673
Query: 671 GSLTQLLKLSNPNKQPWKMKIRLQYRLNGEVKSVQHQLDTFP 796
++TQ++ L+NP K+ +++ +L + L ++ + ++D FP
Sbjct: 674 AAITQVMLLANPLKEKVRLRYKLTFALGEQLSTEVGEVDQFP 715
>sp|P38817|GGA2_YEAST ADP-ribosylation factor binding protein GGA2 (Golgi-localized,
gamma ear-containing, ARF-binding protein 2)
Length = 585
Score = 53.5 bits (127), Expect = 7e-07
Identities = 57/189 (30%), Positives = 80/189 (42%), Gaps = 2/189 (1%)
Frame = +2
Query: 215 PENKTNNAGQLLDLLSLTDPVSSTNNQSTDLNLNGTAISNNSTGNIFDLLGDLSLNSEMP 394
P TNN+ LDLL L+ P S TN+Q+ NS+G FDLL +
Sbjct: 421 PVTTTNNSNNTLDLLGLSTPQSPTNSQAV-----------NSSG--FDLLMGFN------ 461
Query: 395 PISNHKAPSTNATPQISDTKPAISSIIVYESSHGLKLTFSFERISNSQSTVTLHAINNGN 574
P+T T T PA + + S LK+ F R SNS + N +
Sbjct: 462 -------PTTGTT-----TAPARTLV---NQSPNLKIEFEISRESNSVIRIKSFFTNLSS 506
Query: 575 QLIDQFLFQAAVPKSFQLVLLAPSSDNLMPFGG--SLTQLLKLSNPNKQPWKMKIRLQYR 748
I +F AVPKS L L P S N M ++Q + N P K ++++++
Sbjct: 507 SPISNLVFLLAVPKSMSL-KLQPQSSNFMIGNAKDGISQEGTIENAPANPSK-ALKVKWK 564
Query: 749 LNGEVKSVQ 775
+N V S Q
Sbjct: 565 VNYSVNSTQ 573
>sp|Q8R0H9|GGA1_MOUSE ADP-ribosylation factor binding protein GGA1 (Golgi-localized,
gamma ear-containing, ARF-binding protein 1)
(Gamma-adaptin-related protein 1)
Length = 635
Score = 53.1 bits (126), Expect = 1e-06
Identities = 37/135 (27%), Positives = 66/135 (48%), Gaps = 10/135 (7%)
Frame = +2
Query: 422 TNATPQISDTKPA-ISSIIVYESSHGLKLTFSFERIS----NSQSTVTLHAINNGNQLID 586
T+ T + KP+ I + VY+ HG ++ F F R + V + ++ Q I
Sbjct: 494 TSITVPLESIKPSSILPVTVYDQ-HGFRVLFHFARDPLPGRSDVLVVVVSMLSTAPQPIR 552
Query: 587 QFLFQAAVPKSFQLVLLAPSSDNLMPFG-----GSLTQLLKLSNPNKQPWKMKIRLQYRL 751
+FQ+AVPK ++ L PS L F ++TQ+L L+NP K+ +++ +L + +
Sbjct: 553 NIVFQSAVPKVMKVRLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLIFTM 612
Query: 752 NGEVKSVQHQLDTFP 796
+ + +D FP
Sbjct: 613 GDQTYNEMGDVDQFP 627
>sp|Q99128|ADG_USTMA Gamma-adaptin (Golgi adaptor HA1/AP1 adaptin gamma subunit) (Clathrin
assembly protein complex 1 gamma large chain) (Gamma-ADA)
Length = 853
Score = 52.8 bits (125), Expect = 1e-06
Identities = 67/289 (23%), Positives = 118/289 (40%), Gaps = 31/289 (10%)
Frame = +2
Query: 14 QQRSVEFSSIFRNYDNLRIGLLEAMPVMETR-VLSGTLTGNNELTVTEKSNNMPGQLNGY 190
QQRSVEF+++ + D +R G+LE+MP E + + GT++ + T + L G
Sbjct: 566 QQRSVEFATLLKRSD-IRQGVLESMPPPEIKQTVLGTVSEAKPVGSTRSDKDALLDLMGD 624
Query: 191 GCEIIS-------DVPENKTNNAGQLLDLLSLTDPVSSTNNQSTDLNLNGTAISNNSTGN 349
+ S + P T + DLL+ + + + +
Sbjct: 625 EMPVTSGGGTGADNAPSGATQQSTH--DLLADIFGGGDMGGMPSAAPAASASAAQKPKSS 682
Query: 350 IFDLLGDLSLNSEMPPISNHKAP----------------------STNATPQISDTKPAI 463
+ D+LG + P + +AP S+ +TP +
Sbjct: 683 VNDILGLFGDGASAPAAAAQQAPTPAPAATSSYGGLDLLGGLGASSSASTPAATPASTVA 742
Query: 464 SSIIVYESSHGLKLTFSFERISNSQSTVTLHA-INNGNQLIDQFLFQAAVPKSFQLVLLA 640
S VY + HGL +T + V + A + I FQAAVPK+ +L + A
Sbjct: 743 KSHTVY-TKHGLTITLTPTTNPARPEIVHITARFTSATSAISNINFQAAVPKTHKLQMQA 801
Query: 641 PSSDNLMPFGGSLTQLLKLSNPNKQPWKMKIRLQYRLNGEVKSVQHQLD 787
S+ + P + TQ L++ P ++++R+ ++++G SVQ Q D
Sbjct: 802 ISNSTVHP-DSTETQPLRVMVPPGAAVRLRLRIAFQVDGH--SVQDQTD 847
>sp|Q9UJY5|GGA1_HUMAN ADP-ribosylation factor binding protein GGA1 (Golgi-localized,
gamma ear-containing, ARF-binding protein 1)
(Gamma-adaptin related protein 1)
Length = 639
Score = 52.8 bits (125), Expect = 1e-06
Identities = 36/132 (27%), Positives = 64/132 (48%), Gaps = 10/132 (7%)
Frame = +2
Query: 431 TPQISDTKPA-ISSIIVYESSHGLKLTFSFERIS----NSQSTVTLHAINNGNQLIDQFL 595
T + KP+ I + VY+ HG ++ F F R + V + ++ Q I +
Sbjct: 501 TVPLESIKPSNILPVTVYDQ-HGFRILFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIV 559
Query: 596 FQAAVPKSFQLVLLAPSSDNLMPFG-----GSLTQLLKLSNPNKQPWKMKIRLQYRLNGE 760
FQ+AVPK ++ L PS L F ++TQ+L L+NP K+ +++ +L + + +
Sbjct: 560 FQSAVPKVMKVKLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLTFTMGDQ 619
Query: 761 VKSVQHQLDTFP 796
+ +D FP
Sbjct: 620 TYNEMGDVDQFP 631
>sp|Q8BMI3|GGA3_MOUSE ADP-ribosylation factor binding protein GGA3 (Golgi-localized,
gamma ear-containing, ARF-binding protein 3)
Length = 718
Score = 51.2 bits (121), Expect = 4e-06
Identities = 31/128 (24%), Positives = 61/128 (47%), Gaps = 9/128 (7%)
Frame = +2
Query: 440 ISDTKPAISSIIVYESSHGLKLTFSFERISNSQS----TVTLHAINNGNQLIDQFLFQAA 607
+ KP+ + + +G ++ F F + V + +N + + QAA
Sbjct: 583 LESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAA 642
Query: 608 VPKSFQLVLLAPSSDNLMPFG-----GSLTQLLKLSNPNKQPWKMKIRLQYRLNGEVKSV 772
VPKS ++ L PS L PF ++TQ++ L+NP K+ +++ +L + L ++ +
Sbjct: 643 VPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPMKEKVRLRYKLTFALGEQLSTE 702
Query: 773 QHQLDTFP 796
++D FP
Sbjct: 703 LGEVDQFP 710
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 104,361,933
Number of Sequences: 369166
Number of extensions: 2150884
Number of successful extensions: 5300
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4976
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5217
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8550075140
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)