Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_J18
(765 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P12955|PEPD_HUMAN Xaa-Pro dipeptidase (X-Pro dipeptidase... 308 1e-83
sp|Q11136|PEPD_MOUSE Xaa-Pro dipeptidase (X-Pro dipeptidase... 306 4e-83
sp|P43590|YFH6_YEAST Hypothetical 61.8 kDa peptidase in MPR... 156 7e-38
sp|P15034|AMPP_ECOLI Xaa-Pro aminopeptidase (X-Pro aminopep... 149 1e-35
sp|P44881|AMPP_HAEIN Xaa-Pro aminopeptidase (X-Pro aminopep... 140 3e-33
sp|P0A3Z2|AMPP1_STRLI Xaa-Pro aminopeptidase I (X-Pro amino... 115 1e-25
sp|P0A3Z4|AMPP2_STRLI Xaa-Pro aminopeptidase II (X-Pro amin... 102 1e-21
sp|P21165|PEPQ_ECOLI Xaa-Pro dipeptidase (X-Pro dipeptidase... 92 1e-18
sp|P40051|YEQ8_YEAST Hypothetical 58.0 kDa peptidase in PTP... 82 1e-15
sp|P81535|PEPQ_PYRFU Xaa-Pro dipeptidase (X-Pro dipeptidase... 77 7e-14
>sp|P12955|PEPD_HUMAN Xaa-Pro dipeptidase (X-Pro dipeptidase) (Proline dipeptidase)
(Prolidase) (Imidodipeptidase)
Length = 493
Score = 308 bits (788), Expect = 1e-83
Identities = 151/254 (59%), Positives = 181/254 (71%)
Frame = +3
Query: 3 IMRSVHPGMYEYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPNDRKIE 182
+M++V GM EY++ESLF H+CY G MR+ +YT I +G N +VLHYGHAGAPNDR I+
Sbjct: 209 VMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQ 268
Query: 183 DGDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVLAASRAVKNACKPGVRWTD 362
+GDMCLFDMGGEYYC++SDITCSFP NG FT DQK VYEAVL +SRAV A KPGV W D
Sbjct: 269 NGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPD 328
Query: 363 MHLLAERIILSSLKEAGLLQGDVNEMMAVRLGAVFMPHGLGHLLGVDVHDVGGYIEDAIP 542
MH LA+RI L L G+L G V+ M+ LGAVFMPHGLGH LG+DVHDVGGY E +
Sbjct: 329 MHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPE-GVE 387
Query: 543 XXXXXXXXXXXXXXXXQENMVLTVEPGCYFIDFLLDAAINNPEQARFMVINEINRFRRFG 722
Q MVLTVEPG YFID LLD A+ +P +A F+ + RFR FG
Sbjct: 388 RIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFG 447
Query: 723 GVRIEDDIIVTSTG 764
GVRIE+D++VT +G
Sbjct: 448 GVRIEEDVVVTDSG 461
>sp|Q11136|PEPD_MOUSE Xaa-Pro dipeptidase (X-Pro dipeptidase) (Proline dipeptidase)
(Prolidase) (Imidodipeptidase) (Peptidase 4)
Length = 493
Score = 306 bits (784), Expect = 4e-83
Identities = 149/254 (58%), Positives = 180/254 (70%)
Frame = +3
Query: 3 IMRSVHPGMYEYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPNDRKIE 182
+M++V GM EY++ESLF H+CY G MR+ +YT I +G N +VLHYGHAGAPNDR I+
Sbjct: 209 VMKAVKVGMKEYEMESLFQHYCYSRGGMRHTSYTCICCSGENAAVLHYGHAGAPNDRTIK 268
Query: 183 DGDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVLAASRAVKNACKPGVRWTD 362
DGD+CLFDMGGEYYC++SDITCSFP NG FT+DQK +YEAVL + R V + KPGV W D
Sbjct: 269 DGDICLFDMGGEYYCFASDITCSFPANGKFTEDQKAIYEAVLRSCRTVMSTMKPGVWWPD 328
Query: 363 MHLLAERIILSSLKEAGLLQGDVNEMMAVRLGAVFMPHGLGHLLGVDVHDVGGYIEDAIP 542
MH LA+RI L L GLL G V+ M+ V LGAVFMPHGLGH LG+DVHDVGGY E +
Sbjct: 329 MHRLADRIHLEELARIGLLSGSVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYPE-GVE 387
Query: 543 XXXXXXXXXXXXXXXXQENMVLTVEPGCYFIDFLLDAAINNPEQARFMVINEINRFRRFG 722
+ MVLTVEPG YFID LLD A+ +P QA F + RFR FG
Sbjct: 388 RIDEPGLRSLRTARHLEPGMVLTVEPGIYFIDHLLDQALADPAQACFFNQEVLQRFRNFG 447
Query: 723 GVRIEDDIIVTSTG 764
GVRIE+D++VT +G
Sbjct: 448 GVRIEEDVVVTDSG 461
>sp|P43590|YFH6_YEAST Hypothetical 61.8 kDa peptidase in MPR1-GCN20 intergenic region
Length = 535
Score = 156 bits (394), Expect = 7e-38
Identities = 92/259 (35%), Positives = 134/259 (51%), Gaps = 5/259 (1%)
Frame = +3
Query: 3 IMRSVHPGMYEYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPNDRKIE 182
+M ++ + E QI++ F +H G R++ Y I +G C LHY N I+
Sbjct: 254 VMSALPIELNELQIQAEFEYHATRQGG-RSLGYDPICCSGPACGTLHY----VKNSEDIK 308
Query: 183 DGDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVLAASRAVKNACKPGVRWTD 362
L D G E+ Y+SDIT FP +G FT + + VYE VL KPG +W D
Sbjct: 309 GKHSILIDAGAEWRQYTSDITRCFPTSGKFTAEHREVYETVLDMQNQAMERIKPGAKWDD 368
Query: 363 MHLLAERIILSSLKEAGLLQGDV--NEMMAVRLGAVFMPHGLGHLLGVDVHDVGG--YIE 530
+H L ++++ G+ + + +E+ R F PHGLGH+LG+DVHDVGG +
Sbjct: 369 LHALTHKVLIKHFLSMGIFKKEFSEDEIFKRRASCAFYPHGLGHMLGLDVHDVGGNPNYD 428
Query: 531 DAIPXXXXXXXXXXXXXXXXQENMVLTVEPGCYFIDFLLDAAI-NNPEQARFMVINEINR 707
D P +ENMV+T EPGCYF FL+ + +PE+ + ++ + R
Sbjct: 429 DPDP-----MFRYLRIRRPLKENMVITNEPGCYFNQFLIKEFLEKHPERLEVVDMSVLKR 483
Query: 708 FRRFGGVRIEDDIIVTSTG 764
+ GGVRIEDDI+VT G
Sbjct: 484 YMYVGGVRIEDDILVTKDG 502
>sp|P15034|AMPP_ECOLI Xaa-Pro aminopeptidase (X-Pro aminopeptidase) (Aminopeptidase P II)
(APP-II) (Aminoacylproline aminopeptidase)
Length = 441
Score = 149 bits (375), Expect = 1e-35
Identities = 96/253 (37%), Positives = 132/253 (52%)
Frame = +3
Query: 6 MRSVHPGMYEYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPNDRKIED 185
M PGM+EY +E H HGA R +Y +I +G N +LHY N+ ++ D
Sbjct: 200 MEKCRPGMFEYHLEGEIHHEFNRHGA-RYPSYNTIVGSGENGCILHY----TENECEMRD 254
Query: 186 GDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVLAASRAVKNACKPGVRWTDM 365
GD+ L D G EY Y+ DIT +FPVNG FT+ Q+ +Y+ VL + +PG ++
Sbjct: 255 GDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYDIVLESLETSLRLYRPGTSILEV 314
Query: 366 HLLAERIILSSLKEAGLLQGDVNEMMAVRLGAVFMPHGLGHLLGVDVHDVGGYIEDAIPX 545
RI++S L + G+L+GDV+E++A F HGL H LG+DVHDVG Y +D
Sbjct: 315 TGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDVHDVGVYGQD---- 370
Query: 546 XXXXXXXXXXXXXXXQENMVLTVEPGCYFIDFLLDAAINNPEQARFMVINEINRFRRFGG 725
+ MVLTVEPG Y DA + PEQ R + G
Sbjct: 371 ----------RSRILEPGMVLTVEPGLYIAP---DAEV--PEQYRGI------------G 403
Query: 726 VRIEDDIIVTSTG 764
+RIEDDI++T TG
Sbjct: 404 IRIEDDIVITETG 416
>sp|P44881|AMPP_HAEIN Xaa-Pro aminopeptidase (X-Pro aminopeptidase) (Aminopeptidase P II)
(APP-II) (Aminoacylproline aminopeptidase)
Length = 430
Score = 140 bits (354), Expect = 3e-33
Identities = 94/253 (37%), Positives = 130/253 (51%)
Frame = +3
Query: 6 MRSVHPGMYEYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPNDRKIED 185
M++ P +EY+IES LH H A R +Y SI A G N +LHY NDR + D
Sbjct: 193 MQTTRPNRFEYEIESDILHEFNRHCA-RFPSYNSIVAGGSNACILHY----TENDRPLND 247
Query: 186 GDMCLFDMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVLAASRAVKNACKPGVRWTDM 365
GD+ L D G E+ Y+ DIT +FPVNG F++ Q+ +YE VL A + PG
Sbjct: 248 GDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYELVLKAQKRAIELLVPGNSIKQA 307
Query: 366 HLLAERIILSSLKEAGLLQGDVNEMMAVRLGAVFMPHGLGHLLGVDVHDVGGYIEDAIPX 545
+ RI L + G+L+GDV+ ++ + F HGLGH LG+DVHDVG Y +D
Sbjct: 308 NDEVIRIKTQGLVDLGILKGDVDTLIEQQAYRQFYMHGLGHWLGLDVHDVGSYGQD---- 363
Query: 546 XXXXXXXXXXXXXXXQENMVLTVEPGCYFIDFLLDAAINNPEQARFMVINEINRFRRFGG 725
+ MV+TVEPG Y + DA + PEQ + + G
Sbjct: 364 ----------KQRILEIGMVITVEPGIYISE---DADV--PEQYKGI------------G 396
Query: 726 VRIEDDIIVTSTG 764
VRIED++++T G
Sbjct: 397 VRIEDNLLMTEYG 409
>sp|P0A3Z2|AMPP1_STRLI Xaa-Pro aminopeptidase I (X-Pro aminopeptidase I) (Aminopeptidase P
I) (APP) (PEPP I) (Aminoacylproline aminopeptidase I)
sp|P0A3Z1|AMPP1_STRCO Xaa-Pro aminopeptidase I (X-Pro aminopeptidase I) (Aminopeptidase P
I) (APP) (PEPP I) (Aminoacylproline aminopeptidase I)
Length = 491
Score = 115 bits (289), Expect = 1e-25
Identities = 83/250 (33%), Positives = 124/250 (49%), Gaps = 6/250 (2%)
Frame = +3
Query: 33 EYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPNDRKIEDGDMCLFDMG 212
E IE F G +V Y SI A G + LH+ ND + GD+ L D G
Sbjct: 257 ERYIEGTFFLRARVEG--NDVGYGSICAAGPHACTLHW----VRNDGPVRSGDLLLLDAG 310
Query: 213 GEYYCY-SSDITCSFPVNGHFTKDQKIVYEAVLAASRAVKNACKPGVRWTDMHLLAERII 389
E + Y ++D+T + P++G +++ QK +Y+AV A A A +PG ++ D H ++R++
Sbjct: 311 VETHTYYTADVTRTLPISGTYSELQKKIYDAVYDAQEAGIAAVRPGAKYRDFHDASQRVL 370
Query: 390 LSSLKEAGLLQGDVNEMMAVRLGAVFMPHGLGHLLGVDVHD-----VGGYIEDAIPXXXX 554
L E GL++G V ++ + L + HG GH+LG+DVHD V Y++ +
Sbjct: 371 AERLVEWGLVEGPVERVLELGLQRRWTLHGTGHMLGMDVHDCAAARVESYVDGTL----- 425
Query: 555 XXXXXXXXXXXXQENMVLTVEPGCYFIDFLLDAAINNPEQARFMVINEINRFRRFGGVRI 734
+ MVLTVEPG YF QA + + E +R GVRI
Sbjct: 426 ------------EPGMVLTVEPGLYF-------------QADDLTVPE--EYRGI-GVRI 457
Query: 735 EDDIIVTSTG 764
EDDI+VT+ G
Sbjct: 458 EDDILVTADG 467
>sp|P0A3Z4|AMPP2_STRLI Xaa-Pro aminopeptidase II (X-Pro aminopeptidase II) (Aminopeptidase
P II) (APP) (PEPP II) (Aminoacylproline aminopeptidase
II)
sp|P0A3Z3|AMPP2_STRCO Xaa-Pro aminopeptidase II (X-Pro aminopeptidase II) (Aminopeptidase
P II) (APP) (PEPP II) (Aminoacylproline aminopeptidase
II)
Length = 470
Score = 102 bits (254), Expect = 1e-21
Identities = 78/250 (31%), Positives = 112/250 (44%), Gaps = 6/250 (2%)
Frame = +3
Query: 33 EYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPNDRKIEDGDMCLFDMG 212
E +E F G V Y +I A G + +++H+ ND + GD+ L D G
Sbjct: 236 ERWLEGTFFRRARLEG--NAVGYGTICAAGEHATIMHW----TDNDGPVRPGDLLLLDAG 289
Query: 213 GEYYC-YSSDITCSFPVNGHFTKDQKIVYEAVLAASRAVKNACKPGVRWTDMHLLAERII 389
E Y++D+T + P++G FT Q+ VY+AV A A KPG + D H A+R +
Sbjct: 290 VETRSLYTADVTRTLPISGTFTPLQREVYDAVYEAQEAGIATVKPGAAYRDFHEAAQRHL 349
Query: 390 LSSLKEAGLLQGDVNEMMAVRLGAVFMPHGLGHLLGVDVHDVG-----GYIEDAIPXXXX 554
+ L E G ++G + L F G GH+LG+DVHD Y+E +
Sbjct: 350 AARLVEWGFIEGPAERAYELGLQRRFTMAGTGHMLGLDVHDCARARTEEYVEGVL----- 404
Query: 555 XXXXXXXXXXXXQENMVLTVEPGCYFIDFLLDAAINNPEQARFMVINEINRFRRFGGVRI 734
+ M LTVEPG YF + PE+ R + GVRI
Sbjct: 405 ------------EPGMCLTVEPGLYF----QADDLTVPEEWRGI------------GVRI 436
Query: 735 EDDIIVTSTG 764
EDD++VT G
Sbjct: 437 EDDLVVTEDG 446
>sp|P21165|PEPQ_ECOLI Xaa-Pro dipeptidase (X-Pro dipeptidase) (Proline dipeptidase)
(Prolidase) (Imidodipeptidase)
Length = 443
Score = 92.4 bits (228), Expect = 1e-18
Identities = 72/246 (29%), Positives = 114/246 (46%), Gaps = 3/246 (1%)
Frame = +3
Query: 24 GMYEYQIESLFLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPNDRKIEDGDMCLF 203
GM E+ I +L +V Y++I A + +VLHY + + E+ L
Sbjct: 191 GMSEFDINIAYLTATGHRDT--DVPYSNIVALNEHAAVLHYTKL---DHQAPEEMRSFLL 245
Query: 204 DMGGEYYCYSSDITCSFPVNGHFTKDQKIVYEAVLAASRAVKNACKPGVRWTDMHLLAER 383
D G EY Y++D+T ++ D + + V A+ K GV + D H+ +
Sbjct: 246 DAGAEYNGYAADLTRTWSAKSD--NDYAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQ 303
Query: 384 IILSSLKEAGLLQGDVNEMMAVR-LGAVFMPHGLGHLLGVDVHDVGGYIED--AIPXXXX 554
I L++ ++ E M L FMPHG+GH LG+ VHDV G+++D
Sbjct: 304 RIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAP 363
Query: 555 XXXXXXXXXXXXQENMVLTVEPGCYFIDFLLDAAINNPEQARFMVINEINRFRRFGGVRI 734
Q MVLT+EPG YFI+ LL A + ++ +I + FGG+RI
Sbjct: 364 AKYPYLRCTRILQPGMVLTIEPGIYFIESLL-APWREGQFSKHFNWQKIEALKPFGGIRI 422
Query: 735 EDDIIV 752
ED++++
Sbjct: 423 EDNVVI 428
>sp|P40051|YEQ8_YEAST Hypothetical 58.0 kDa peptidase in PTP3-ILV1 intergenic region
Length = 511
Score = 82.4 bits (202), Expect = 1e-15
Identities = 67/235 (28%), Positives = 102/235 (43%), Gaps = 2/235 (0%)
Frame = +3
Query: 54 FLHHCYFHGAMRNVAYTSIGATGCNCSVLHYGHAGAPNDRKIEDGDMCLFDMGGEYYCYS 233
FLH+ + G AY + ATG N +HY ND + D +M L D G Y
Sbjct: 281 FLHYKFISGGCDKDAYIPVVATGSNSLCIHYTR----NDDVMFDDEMVLVDAAGSLGGYC 336
Query: 234 SDITCSFPVNGHFTKDQKIVYEAVLAASRAVKNACKPGVRWT--DMHLLAERIILSSLKE 407
+DI+ ++P +G FT Q+ +YEAVL R CK ++ D+H + ++ LK
Sbjct: 337 ADISRTWPNSGKFTDAQRDLYEAVLNVQRDCIKLCKASNNYSLHDIHEKSITLMKQELKN 396
Query: 408 AGLLQGDVNEMMAVRLGAVFMPHGLGHLLGVDVHDVGGYIEDAIPXXXXXXXXXXXXXXX 587
G ++++ + ++ PH +GH LG+DVHDV
Sbjct: 397 LG-----IDKVSGWNVEKLY-PHYIGHNLGLDVHDV----------------PKVSRYEP 434
Query: 588 XQENMVLTVEPGCYFIDFLLDAAINNPEQARFMVINEINRFRRFGGVRIEDDIIV 752
+ V+T+EPG Y P + F + R G+RIEDDI +
Sbjct: 435 LKVGQVITIEPGLYI-----------PNEESF------PSYFRNVGIRIEDDIAI 472
>sp|P81535|PEPQ_PYRFU Xaa-Pro dipeptidase (X-Pro dipeptidase) (Proline dipeptidase)
(Prolidase) (Imidodipeptidase)
Length = 348
Score = 76.6 bits (187), Expect = 7e-14
Identities = 64/226 (28%), Positives = 100/226 (44%), Gaps = 3/226 (1%)
Frame = +3
Query: 96 AYTSIGATGCNCSVLHYGHAGAPNDRKIEDGDMCLFDMGGEYYCYSSDITCSFPVNGHFT 275
A+ +I A+G ++ H G +D++IE GD+ + D+G Y Y+SDIT + V G
Sbjct: 177 AFDTIIASGHRSALPH----GVASDKRIERGDLVVIDLGALYNHYNSDITRTIVV-GSPN 231
Query: 276 KDQKIVYEAVLAASRAVKNACKPGVRWTDMHLLAERIILSSLKEAGLLQGDVNEMMAVRL 455
+ Q+ +YE VL A + A KPG+ ++ +A II KE G GD
Sbjct: 232 EKQREIYEIVLEAQKRAVEAAKPGMTAKELDSIAREII----KEYG--YGD--------- 276
Query: 456 GAVFMPHGLGHLLGVDVHD---VGGYIEDAIPXXXXXXXXXXXXXXXXQENMVLTVEPGC 626
+ H LGH +G+++H+ + Y E + +E MV+T+EPG
Sbjct: 277 ---YFIHSLGHGVGLEIHEWPRISQYDETVL-----------------KEGMVITIEPGI 316
Query: 627 YFIDFLLDAAINNPEQARFMVINEINRFRRFGGVRIEDDIIVTSTG 764
Y + GGVRIED +++T G
Sbjct: 317 Y--------------------------IPKLGGVRIEDTVLITENG 336
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,999,364
Number of Sequences: 369166
Number of extensions: 1793719
Number of successful extensions: 4165
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3980
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4106
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7066925600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)