Planaria EST Database

Dr_sW_008_I09

ACCESSION : BW637442
GO Category : Not Available
EST Sequence :
>Dr_sW_008_I09 TGGAATGAGCGCAGATTTCTTTATGAACAAAATATGGATCTCCAATTGTTTTATCGCGAT ACTGAGCAAGCTGAAGCATGGATTGCTAAGCAAGAAGCTTTTCTGGAGAATAATGATGTC GGTGATTCGTTAGATTCTGTTGAAGCGTTAATTCGTAAACATGAAGATTTTGAAAAGTCA TTAGCTGCACAAGAAGAAAAAACACAAAGGCTTGATGATATTGCCAATAAATTAGTTGAA AATGGACATTATGCTGCTGCAGATGTTAATAAAAAACGTGATGATTTATTGATAAGGAAG GCTAATTTAGAGGAAAAGGCAAAATTACGAAAAGGAAGTTTGGAGGATTCTCACAACTAT CAATTATTTGATCGAGATGCAGATGAAATAAAGGCTTGGATTGTTGAAAAGTTGAAAACA GCATCTGATGAAAATTATAAAGAACCAACAAATCTTCAATCTAAAGTTCAAAAACATCAG AACTTTTTAGCTGAAATAGCTGCAAATGAGGGTAGAATTGATGATGTAAAAAGTCGAGGA CAAAGTTTATTAGATTCAGATCACAATAAATCAGATGATATTCAACAAAGAATAGAGGAA CTTGATAAATTATGGAAGGATCTAGTTTCAGCATCAAAGATTAAAGAAACAAATCTAACT CAAGCAAGTGGACAGCAACAGTTTATTAGAAATGTTGAAGATATGGAAATATGGTTGGCT GAAGTGGAATCGCAGTTAGGTTCAGACGATTGTGGAAAAGATCTTAATAGTGTTACCAAT TTGCAGAAAAAACATAATTT

BLASTX 2.2.12 [Aug-07-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Dr_sW_008_I09
         (800 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|P13395|SPTCA_DROME  Spectrin alpha chain                       320   2e-87
sp|P07751|SPTA2_CHICK  Spectrin alpha chain, brain (Spectrin...   318   1e-86
sp|Q13813|SPTA2_HUMAN  Spectrin alpha chain, brain (Spectrin...   315   7e-86
sp|P16086|SPTA2_RAT  Spectrin alpha chain, brain (Spectrin, ...   314   2e-85
sp|P16546|SPTA2_MOUSE  Spectrin alpha chain, brain (Spectrin...   243   3e-64
sp|P02549|SPTA1_HUMAN  Spectrin alpha chain, erythrocyte (Er...   241   2e-63
sp|P08032|SPTA1_MOUSE  Spectrin alpha chain, erythrocyte (Er...   237   2e-62
sp|Q01082|SPTB2_HUMAN  Spectrin beta chain, brain 1 (Spectri...   164   3e-40
sp|Q9QWN8|SPTN2_RAT  Spectrin beta chain, brain 2 (Spectrin,...   161   2e-39
sp|O15020|SPTN2_HUMAN  Spectrin beta chain, brain 2 (Spectri...   154   2e-37

>sp|P13395|SPTCA_DROME Spectrin alpha chain
          Length = 2415

 Score =  320 bits (821), Expect = 2e-87
 Identities = 159/265 (60%), Positives = 199/265 (75%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W +RR LYEQ MDLQLFYRDTEQA+ W+AKQEAFL N D+GDSLDSVEALI+KHEDFEKS
Sbjct: 459  WEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKS 518

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            LAAQEEK + LD  A KL++  HYAA DV ++R  LL R+A L+EK+  R+  LEDS+ Y
Sbjct: 519  LAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRY 578

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q F+RD DE K WI EKLK A+D++Y +PTNL  K+QKHQNF  E+ AN+ RI+D+ + G
Sbjct: 579  QQFERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVG 638

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
              L++  H  +D I  R++E+  LW+ LV AS  K T L +A  QQQF R +ED+E+WL+
Sbjct: 639  TELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLS 698

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
            E+E QL S+D GKDL SV NLQKKH
Sbjct: 699  EIEGQLLSEDHGKDLTSVQNLQKKH 723


 Score =  230 bits (587), Expect = 3e-60
 Identities = 119/267 (44%), Positives = 173/267 (64%), Gaps = 2/267 (0%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W ERR   EQN+DLQL+ RD E AE+W++ +EAFL  +D  ++  +VEALI+KHEDF+K+
Sbjct: 1382 WTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKA 1441

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            +   E+K   L  +A++L+   HYA+  V++KR  +L R  +L+E    ++  L D    
Sbjct: 1442 INGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTL 1501

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q F RDADEI+ WI EKL+ A++E+YK+P N+QSK QKHQ F AE+AAN  RI  V + G
Sbjct: 1502 QQFSRDADEIENWIAEKLQLATEESYKDPANIQSKHQKHQAFEAELAANADRIQSVLAMG 1561

Query: 541  QSLLDSDH--NKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIW 714
             +L+D        D +Q+R+ ++   W+ L   +  K   L +A+ Q+ +I  V+D++ W
Sbjct: 1562 GNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFW 1621

Query: 715  LAEVESQLGSDDCGKDLNSVTNLQKKH 795
            L EVES L ++D GKDL SV NL KKH
Sbjct: 1622 LGEVESLLTTEDSGKDLASVQNLMKKH 1648


 Score =  146 bits (368), Expect = 7e-35
 Identities = 71/177 (40%), Positives = 117/177 (66%)
 Frame = +1

Query: 262 DVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDENYK 441
           D+ ++R+ +L R  + + + + ++  LEDS  +Q F RDADE+++WI EKL+ AS+E+Y+
Sbjct: 17  DIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAASEESYR 76

Query: 442 EPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLWKD 621
           +PTNLQ+K+QKHQ F AE++A+   I  + + GQ +++  H  S+ IQ R++EL KLW+ 
Sbjct: 77  DPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWEL 136

Query: 622 LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
           L+S    K   L QA    QF+R  E++  W+ + E+ + +D+ G+DL  V  LQ+K
Sbjct: 137 LLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRK 193


 Score =  136 bits (343), Expect = 6e-32
 Identities = 85/252 (33%), Positives = 130/252 (51%), Gaps = 1/252 (0%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            Q F R  E  E W+++ E  L + D G  L SV+ L +KH   E  + A +++ + +   
Sbjct: 684  QQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVA 743

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            ANK +E+GH+ A ++  K  +L  R A L      RK  L DS   Q   RD ++  AWI
Sbjct: 744  ANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWI 803

Query: 403  VEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDD 579
             EK   A+  N  ++   +Q+ ++KHQ  LAEI  +E R+ +V S G+++L      SDD
Sbjct: 804  REKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLKDQPFASDD 863

Query: 580  IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGK 759
            I+QR+E L + W  L   S  ++ +L  +    Q+  +  + E W+ E E      D GK
Sbjct: 864  IRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPIATGSDYGK 923

Query: 760  DLNSVTNLQKKH 795
            D +S   L KKH
Sbjct: 924  DEDSSEALLKKH 935


 Score =  136 bits (342), Expect = 8e-32
 Identities = 72/264 (27%), Positives = 145/264 (54%), Gaps = 1/264 (0%)
 Frame = +1

Query: 7   ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
           E+    +Q + L  F R  E+   WI  +E F+  ++ G  L+ VE L RK ++F+K +A
Sbjct: 143 EKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMA 202

Query: 187 AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
           +QE +   ++ +A+KLV++GH     + K++++L      L++ A +R+  L  +H  Q 
Sbjct: 203 SQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQR 262

Query: 367 FDRDADEIKAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
           F+RDADE  AWI EK    S ++Y ++  ++Q+  +KH+    ++AA E ++  + +  Q
Sbjct: 263 FNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQ 322

Query: 544 SLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE 723
            L     + SD I+ +  E+   W+ L + ++ ++  L ++    +F+ +  D+  W+  
Sbjct: 323 RLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWING 382

Query: 724 VESQLGSDDCGKDLNSVTNLQKKH 795
           +++ + +D+  KD+     L ++H
Sbjct: 383 MKAIISADELAKDVAGAEALLERH 406


 Score =  134 bits (337), Expect = 3e-31
 Identities = 82/254 (32%), Positives = 136/254 (53%), Gaps = 1/254 (0%)
 Frame = +1

Query: 37   DLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLD 216
            ++Q F+RD ++ + WIA++   L N+D+G  L SV+ L RKHE  E+ LAA  +K ++LD
Sbjct: 1182 EVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQLD 1241

Query: 217  DIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKA 396
            + AN+L+++    A     K+ ++      +  K+  RK  L DS++ Q F  D  ++ A
Sbjct: 1242 ETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLA 1301

Query: 397  WIVEKLK-TASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKS 573
            WI   +    SDE   + T  ++ +++HQ    EI A  G     +  G  LL ++H  S
Sbjct: 1302 WINSMMSLVTSDELANDVTGAEALIERHQEHRTEIDARAGTFGAFEQFGNELLQANHYAS 1361

Query: 574  DDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDC 753
             +I+++IE+L K  +DL  A   +   L Q    Q ++R+ E  E W++  E+ L +DD 
Sbjct: 1362 PEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDD 1421

Query: 754  GKDLNSVTNLQKKH 795
                 +V  L KKH
Sbjct: 1422 ANAGGNVEALIKKH 1435


 Score =  129 bits (325), Expect = 7e-30
 Identities = 71/241 (29%), Positives = 132/241 (54%), Gaps = 1/241 (0%)
 Frame = +1

Query: 79   WIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDIANKLVENGHYAA 258
            W+ + E+ L   D G  L SV+ L++KH+  E  + A E++ + +++ A+ LVE+G +  
Sbjct: 1621 WLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQFDT 1680

Query: 259  ADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEK-LKTASDEN 435
            A + +KR  +  R   +   A  R+  L ++     F RD  + ++WI EK L   SD+ 
Sbjct: 1681 AGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDY 1740

Query: 436  YKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLW 615
             ++ T +Q+  +KH+   AE+ ++E  I  V+  G+ L+D  +    +I+QR++ L++ W
Sbjct: 1741 GRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQAW 1800

Query: 616  KDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKH 795
             +L + +  +   L ++   QQF+  VE+ E W+ E +  L  +D G  + +V  L KKH
Sbjct: 1801 AELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGDSMAAVQGLLKKH 1860

Query: 796  N 798
            +
Sbjct: 1861 D 1861


 Score =  126 bits (316), Expect = 8e-29
 Identities = 79/254 (31%), Positives = 132/254 (51%), Gaps = 1/254 (0%)
 Frame = +1

Query: 37   DLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLD 216
            ++Q F RD ++  AWIA+++  L ++D G  L SV+AL RKHE  E+ LAA E+K   L 
Sbjct: 259  EIQRFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLG 318

Query: 217  DIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKA 396
              A +L       +  +  K+ ++     +L  KA+ RK  L++S+    F  D  ++ +
Sbjct: 319  AEAQRLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVS 378

Query: 397  WIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKS 573
            WI   K   ++DE  K+    ++ +++HQ    EI A E         GQ LL+ +H  +
Sbjct: 379  WINGMKAIISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAA 438

Query: 574  DDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDC 753
             +IQ+++  L+     L+S  + +     Q    Q F R+ E  + W+A+ E+ L ++D 
Sbjct: 439  AEIQEKLAALENDKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDL 498

Query: 754  GKDLNSVTNLQKKH 795
            G  L+SV  L KKH
Sbjct: 499  GDSLDSVEALIKKH 512


 Score =  123 bits (308), Expect = 7e-28
 Identities = 69/265 (26%), Positives = 143/265 (53%), Gaps = 1/265 (0%)
 Frame = +1

Query: 4    NERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSL 183
            ++RR L E +   Q F RD ++ + WI+++  F  ++   D  + +   ++KH++FE  L
Sbjct: 566  SKRRQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSYLDPTN-LNGKMQKHQNFEHEL 624

Query: 184  AAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQ 363
             A + + + + ++  +L+E  HYAA  +N +  ++++    L + +  +   L ++   Q
Sbjct: 625  NANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQ 684

Query: 364  LFDRDADEIKAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
             F+R  ++I+ W+ E + +  S+++ K+ T++Q+  +KH    A++ A++ RI+ +K   
Sbjct: 685  QFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAA 744

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
               ++S H  +D+I+ +   L   +  L +    ++ +L  +   QQ  R++ED   W+ 
Sbjct: 745  NKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWIR 804

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
            E E    S + G+DL  V NL KKH
Sbjct: 805  EKEPIAASTNRGRDLIGVQNLIKKH 829


 Score =  115 bits (287), Expect = 2e-25
 Identities = 71/267 (26%), Positives = 139/267 (52%), Gaps = 4/267 (1%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            E+R        LQ F RD ++ E WIA++          D  + +++  +KH+ FE  LA
Sbjct: 1490 EKRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEESYKDPAN-IQSKHQKHQAFEAELA 1548

Query: 187  AQEEKTQRLDDIANKLVENGHYAAAD--VNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            A  ++ Q +  +   L++    + ++  V K+   +  +   L  K   +   L++++  
Sbjct: 1549 ANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQ 1608

Query: 361  QLFDRDADEIKAWI--VEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKS 534
            + +     ++  W+  VE L T  D   K+  ++Q+ ++KHQ   A+I A+E RI D+ +
Sbjct: 1609 RTYIAAVKDLDFWLGEVESLLTTEDSG-KDLASVQNLMKKHQLVEADIVAHEDRIKDMNN 1667

Query: 535  RGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIW 714
            +  SL++S    +  IQ++ + +++ ++ + + +  ++  L +A    QF R++ D E W
Sbjct: 1668 QADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESW 1727

Query: 715  LAEVESQLGSDDCGKDLNSVTNLQKKH 795
            + E +  +GSDD G+DL  V NL+KKH
Sbjct: 1728 IKEKKLLVGSDDYGRDLTGVQNLKKKH 1754


 Score =  112 bits (279), Expect = 2e-24
 Identities = 68/262 (25%), Positives = 132/262 (50%), Gaps = 1/262 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            R+    + + L  F+RD    E+WI +++  + ++D G  L  V+ L +KH+  E  L +
Sbjct: 1704 RQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGS 1763

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
             E   Q + +   KL++  +    ++ ++   L    A L+  A  R   L++S  YQ F
Sbjct: 1764 HEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQF 1823

Query: 370  DRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
                +E +AWI EK +  S E+Y +    +Q  ++KH  F  +  A++ R   +  +G  
Sbjct: 1824 LAQVEEEEAWITEKQQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSE 1883

Query: 547  LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
            L+++ ++  + I QR ++L     +L + +  ++  L   S   QF+   + +E W+ + 
Sbjct: 1884 LVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDK 1943

Query: 727  ESQLGSDDCGKDLNSVTNLQKK 792
            E+ + SD+ G+DL++V  L  K
Sbjct: 1944 ENYVRSDEFGRDLSTVQTLLTK 1965


 Score =  111 bits (278), Expect = 2e-24
 Identities = 70/264 (26%), Positives = 131/264 (49%), Gaps = 1/264 (0%)
 Frame = +1

Query: 7   ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
           ++R   E +   Q F RD ++ E+WI ++          D  + ++A I+KH+ FE  ++
Sbjct: 38  QKREKLEDSRRFQYFKRDADELESWIHEKLQAASEESYRDPTN-LQAKIQKHQAFEAEVS 96

Query: 187 AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
           A       LD+   +++   H+A+  +  + D+L      L  +   +   L+ +     
Sbjct: 97  AHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLSRLAEKGLKLQQALVLVQ 156

Query: 367 FDRDADEIKAWIVEK-LKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
           F R  +E+  WI +K     +DE  ++  +++   +K   F  ++A+ E R+ +V     
Sbjct: 157 FLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYRVTEVNQLAD 216

Query: 544 SLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE 723
            L+   H + D I +R EEL++ W+ L   + +++  L  A   Q+F R+ ++   W+AE
Sbjct: 217 KLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIAE 276

Query: 724 VESQLGSDDCGKDLNSVTNLQKKH 795
            +  L SDD G+DL SV  LQ+KH
Sbjct: 277 KDVVLSSDDYGRDLASVQALQRKH 300


 Score =  101 bits (252), Expect = 2e-21
 Identities = 67/242 (27%), Positives = 128/242 (52%), Gaps = 2/242 (0%)
 Frame = +1

Query: 25   EQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKT 204
            ++++  Q F    E+ EAWI +++  L   D GDS+ +V+ L++KH+ FE    A +++ 
Sbjct: 1815 DESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHKDRC 1874

Query: 205  QRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDAD 384
              + D  ++LVE  ++    + ++   L ++  NL   A  RKG+L D+  Y  F   AD
Sbjct: 1875 SLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKAD 1934

Query: 385  EIKAWIVEKLK-TASDENYKEPTNLQSKVQKHQNFLAEIAANEGR-IDDVKSRGQSLLDS 558
             +++WI +K     SDE  ++ + +Q+ + K + F A + A E   I ++ +    L+++
Sbjct: 1935 VVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQEGIHNITALKDQLINA 1994

Query: 559  DHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQL 738
             H +S  I +R  ++   W+ L  AS  ++  L   + Q+QF R +E++ +  A+  S  
Sbjct: 1995 SHAQSPAILKRHGDVIARWQKLRDASNTRKDRL--LAMQEQF-RQIEELYLTFAKKASAF 2051

Query: 739  GS 744
             S
Sbjct: 2052 NS 2053


 Score =  101 bits (251), Expect = 3e-21
 Identities = 64/264 (24%), Positives = 133/264 (50%), Gaps = 1/264 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER+   +++  L  F  D     +WI   +A +  +++   +   EAL+ +H++ +  + 
Sbjct: 355  ERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLERHQEHKGEID 414

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            A+E+  +   +   KL+E  HYAAA++ +K   L   K++L    + R+   E   + QL
Sbjct: 415  AREDSFKLTTESGQKLLEREHYAAAEIQEKLAALENDKSSLLSLWEDRRILYEQCMDLQL 474

Query: 367  FDRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
            F RD ++   W+ ++    ++E+  +   ++++ ++KH++F   +AA E +I  +     
Sbjct: 475  FYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALDIFAT 534

Query: 544  SLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE 723
             L+D  H  +DD+ QR + L      L   S  +   L  ++  QQF R+ ++ + W++E
Sbjct: 535  KLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISE 594

Query: 724  VESQLGSDDCGKDLNSVTNLQKKH 795
             + +  +DD   D  ++    +KH
Sbjct: 595  -KLKFATDDSYLDPTNLNGKMQKH 617


 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 50/183 (27%), Positives = 96/183 (52%), Gaps = 6/183 (3%)
 Frame = +1

Query: 265  VNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTAS-----D 429
            + K+++ +  +  NL   A+ R+  L ++    +  R+A ++  WI +K   A       
Sbjct: 1044 IAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIADVVG 1103

Query: 430  ENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSD-DIQQRIEELD 606
            E+ +E   LQ   +K  +F  ++ ANE R+ ++      L      ++   IQ ++++L+
Sbjct: 1104 EDLEEVEVLQ---KKFDDFNDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLN 1160

Query: 607  KLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQ 786
            + W +L + +  K + L  A   Q+F R++++ + W+AE  + L +DD GKDL SV  LQ
Sbjct: 1161 EKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQ 1220

Query: 787  KKH 795
            +KH
Sbjct: 1221 RKH 1223


 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 55/250 (22%), Positives = 114/250 (45%), Gaps = 5/250 (2%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER+     ++ +Q  +RD E   AWI ++E    + + G  L  V+ LI+KH+     + 
Sbjct: 778  ERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEIN 837

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
              E +   +      ++++  +A+ D+ ++ + L  +   L+EK+  RK  L+DS     
Sbjct: 838  NHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQ 897

Query: 367  FDRDADEIKAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
            +  DA+E ++W+ EK   A+  +Y K+  + ++ ++KH          E  + D+++ G 
Sbjct: 898  YFADANEAESWMREKEPIATGSDYGKDEDSSEALLKKH----------EALVSDLEAFGN 947

Query: 544  SLLDSDHNKSDDIQQRIEELDKLWKDLVSA----SKIKETNLTQASGQQQFIRNVEDMEI 711
            ++        +  QQ    +D   K+ V A    ++     ++   G    + N  + + 
Sbjct: 948  TIQALQEQAKNCRQQETPVVDITGKECVVALYDYTEKSpreVSMKKGDVLTLLNSNNKDW 1007

Query: 712  WLAEVESQLG 741
            W  EV  + G
Sbjct: 1008 WKVEVNDRQG 1017


 Score = 34.3 bits (77), Expect = 0.41
 Identities = 22/73 (30%), Positives = 39/73 (53%)
 Frame = +1

Query: 574 DDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDC 753
           +DIQ+R E++   + D    ++ K   L  +   Q F R+ +++E W+ E + Q  S++ 
Sbjct: 16  EDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHE-KLQAASEES 74

Query: 754 GKDLNSVTNLQKK 792
            +D    TNLQ K
Sbjct: 75  YRD---PTNLQAK 84

>sp|P07751|SPTA2_CHICK Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
            (Fodrin alpha chain)
          Length = 2477

 Score =  318 bits (814), Expect = 1e-86
 Identities = 157/265 (59%), Positives = 199/265 (75%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W  RR  YEQ MDLQLFYRDTEQ + W++KQEAFL N D+GDSLDSVEAL++KHEDFEKS
Sbjct: 456  WELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKS 515

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            L+AQEEK   LD+ A KL++N HYA  DV  +RD LL R+  L E+A  R+  L DS + 
Sbjct: 516  LSAQEEKITALDEFATKLIQNNHYAMDDVATRRDALLSRRNALHERAMKRRAQLADSFHL 575

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q F RD+DE+K+W+ EK+KTA+DE YK+P+NLQ KVQKHQ F AE++AN+ RID ++  G
Sbjct: 576  QQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAG 635

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
            Q L+D +H  SD++  R+ E+  LWK L+ A+++K   L +A+ QQQF RNVED+E+WL 
Sbjct: 636  QKLIDVNHYASDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLY 695

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
            EVE  L SDD GKDL SV NLQKKH
Sbjct: 696  EVEGHLASDDYGKDLTSVQNLQKKH 720


 Score =  234 bits (598), Expect = 2e-61
 Identities = 127/272 (46%), Positives = 173/272 (63%), Gaps = 7/272 (2%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W +RR + +Q ++LQLF+RD EQAE W+A +EAFL   D GDSLDSVEALI+KHEDF+K+
Sbjct: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKA 1493

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            +  QEEK   L   A++L+   HYA   +  +R+++L R   L+ +   ++  L +S   
Sbjct: 1494 INVQEEKIAVLQSFADQLIAADHYAKGVIANRRNEVLDRWRRLKAQMIEKRSKLGESQTL 1553

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQ-----SKVQKHQNFLAEIAANEGRIDD 525
            Q F RD DEI+AWI EKL+TASDE+YK+PTN+Q     SK QKHQ F AE+ AN  RI  
Sbjct: 1554 QQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRG 1613

Query: 526  VKSRGQSLLD--SDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVE 699
            V   G  L++  +     D ++ R+  L   W+ LV  S  K   L +A+ QQ F   ++
Sbjct: 1614 VIEMGNPLIERGACAGSEDAVKARLAALADQWEFLVQKSSEKSQKLKEANKQQNFNTGIK 1673

Query: 700  DMEIWLAEVESQLGSDDCGKDLNSVTNLQKKH 795
            D + WL+EVE+ L S+D GKDL SV NL KKH
Sbjct: 1674 DFDFWLSEVEALLASEDYGKDLASVNNLLKKH 1705


 Score =  152 bits (385), Expect = 8e-37
 Identities = 77/179 (43%), Positives = 113/179 (63%)
 Frame = +1

Query: 256 AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDEN 435
           A D+ ++R  +L R    +E + LR+  LEDS+ +Q F RDADE+  WI EKL+ ASDEN
Sbjct: 12  AEDIQERRQQVLDRYHRFKELSSLRRQKLEDSYRFQFFQRDADELGKWIQEKLQIASDEN 71

Query: 436 YKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLW 615
           YK+P+NLQ K+QKHQ F AE+ AN G I  +   G  +++  H  S+ I+ R++EL +LW
Sbjct: 72  YKDPSNLQGKLQKHQAFEAEVQANSGAIVKLDETGNQMINEGHFASETIRTRLQELHRLW 131

Query: 616 KDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
           + L+   + K   L QA    QF+R  ED+  W+ + E+ + S++ G+DL  V  LQKK
Sbjct: 132 ELLLEKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190


 Score =  140 bits (354), Expect = 3e-33
 Identities = 79/252 (31%), Positives = 136/252 (53%), Gaps = 1/252 (0%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            Q F    +  + W+++ EA L + D G  L SV  L++KH+  E  ++A E++ + L+  
Sbjct: 1666 QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            A+ L+ +  +  + V  KR+ +  R   ++  A  R+  L +SH    F RD D+ ++WI
Sbjct: 1726 ADSLMTSSAFDTSQVKDKRETINGRFQRIKSMAAARRAKLNESHRLHQFFRDMDDEESWI 1785

Query: 403  VEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDD 579
             EK    S E+Y ++ T +Q+  +KH+   AE+AA+E  I  V   G+ L D +    ++
Sbjct: 1786 KEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE 1845

Query: 580  IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGK 759
            IQQR+ +    WK+L   +  +   L ++   QQF+ NVE+ E W+ E  + + S+D G 
Sbjct: 1846 IQQRLAQFVDHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD 1905

Query: 760  DLNSVTNLQKKH 795
             L ++  L KKH
Sbjct: 1906 TLAAIQGLLKKH 1917


 Score =  138 bits (348), Expect = 2e-32
 Identities = 79/252 (31%), Positives = 135/252 (53%), Gaps = 1/252 (0%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            Q F R+ E  E W+ + E  L ++D G  L SV+ L +KH   E  +AA ++    +   
Sbjct: 681  QQFNRNVEDIELWLYEVEGHLASDDYGKDLTSVQNLQKKHALLEADVAAHQDPIDGITIQ 740

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            A +  + GH+ A ++ KK++ L+ R   L++    RK  L DS   Q   RD ++ + WI
Sbjct: 741  ARQFQDAGHFDADNIKKKQEALVARYEALKDPMVARKQKLADSLRLQQLFRDIEDEETWI 800

Query: 403  VEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDD 579
             EK   A+  N  K+   +Q+ ++KHQ   AEIA +E RI  V  +G ++++  H  ++D
Sbjct: 801  REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAED 860

Query: 580  IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGK 759
            ++ ++ EL++ W  L + +  +  +L  +   QQ+  +  + + W+ E E  +GS D GK
Sbjct: 861  VKIKLNELNQKWDSLKAKASQRRQDLEDSLQAQQYFADANEAQSWMREKEPIVGSTDYGK 920

Query: 760  DLNSVTNLQKKH 795
            D +S   L KKH
Sbjct: 921  DEDSAEALLKKH 932


 Score =  133 bits (335), Expect = 5e-31
 Identities = 88/265 (33%), Positives = 140/265 (52%), Gaps = 2/265 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER  L     ++Q F+RD ++ + WI ++   L  ++ G  L SV+AL R  E FE+ LA
Sbjct: 1224 ERSQLLGSADEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRNDEGFERDLA 1283

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            A  +K   L + A +L+++    A D+ +K  +L    ++L ++A  RK  L DSH+ Q 
Sbjct: 1284 ALGDKVNSLGETAQRLIQSHPELAEDLQEKCTELNQAWSSLGKRADQRKEKLGDSHDLQR 1343

Query: 367  FDRDADEIKAWI--VEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            F  D  ++ +WI  +  L  +SDE  K+ T  ++ +++HQ    EI A  G     +  G
Sbjct: 1344 FLSDFRDLMSWINGIRGL-VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 1402

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
            Q LL   H  S +I+++++ LD+   DL  A   +   L Q    Q F R+ E  E W+A
Sbjct: 1403 QQLLARGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMA 1462

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
              E+ L ++D G  L+SV  L KKH
Sbjct: 1463 AREAFLNTEDKGDSLDSVEALIKKH 1487


 Score =  128 bits (322), Expect = 2e-29
 Identities = 73/264 (27%), Positives = 144/264 (54%), Gaps = 1/264 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            +RR     +  LQ F+RD+++ ++W+ ++     +    D   +++  ++KH+ FE  L+
Sbjct: 564  KRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP-SNLQGKVQKHQAFEAELS 622

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            A + +   L+    KL++  HYA+ +V  + ++++     L E  +L+   L +++  Q 
Sbjct: 623  ANQSRIDALEKAGQKLIDVNHYASDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQ 682

Query: 367  FDRDADEIKAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
            F+R+ ++I+ W+ E +   ASD+  K+ T++Q+  +KH    A++AA++  ID +  + +
Sbjct: 683  FNRNVEDIELWLYEVEGHLASDDYGKDLTSVQNLQKKHALLEADVAAHQDPIDGITIQAR 742

Query: 544  SLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE 723
               D+ H  +D+I+++ E L   ++ L      ++  L  +   QQ  R++ED E W+ E
Sbjct: 743  QFQDAGHFDADNIKKKQEALVARYEALKDPMVARKQKLADSLRLQQLFRDIEDEETWIRE 802

Query: 724  VESQLGSDDCGKDLNSVTNLQKKH 795
             E    S + GKDL  V NL KKH
Sbjct: 803  KEPIAASTNRGKDLIGVQNLLKKH 826


 Score =  126 bits (317), Expect = 6e-29
 Identities = 74/262 (28%), Positives = 136/262 (51%), Gaps = 1/262 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR    ++  L  F+RD +  E+WI +++  + + D G  L  V+ L +KH+  E  LAA
Sbjct: 1761 RRAKLNESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAA 1820

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
             E   Q + D   KL ++      ++ ++    +     L++ A  R   LE+S  YQ F
Sbjct: 1821 HEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVDHWKELKQLAAARGQRLEESLEYQQF 1880

Query: 370  DRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
              + +E +AWI EK+   + E+Y +    +Q  ++KH+ F  +   ++ R++DV + G+ 
Sbjct: 1881 VANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCANGED 1940

Query: 547  LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
            L+  +++  ++I  +++ L     DL  A+  ++  L + S   QF    + +E W+ E 
Sbjct: 1941 LIKKNNHHVENITAKMKGLKGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEK 2000

Query: 727  ESQLGSDDCGKDLNSVTNLQKK 792
            E+ L +DD G+DL+SV  L  K
Sbjct: 2001 ENSLKTDDYGRDLSSVQTLLTK 2022


 Score =  119 bits (299), Expect = 7e-27
 Identities = 69/257 (26%), Positives = 131/257 (50%), Gaps = 1/257 (0%)
 Frame = +1

Query: 28  QNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQ 207
           Q   L  F R+ E    WI  +EA + + ++G  L+ VE L +K E+F+  LAA EE+  
Sbjct: 147 QAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVN 206

Query: 208 RLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADE 387
            ++  A KL++  H     +  K+D++      L+  A+ R+G L  +   Q F+RD DE
Sbjct: 207 EVNQFAGKLIQEQHPEEELIKSKQDEVNASWQRLKGLAQQRQGKLFGAAEVQRFNRDVDE 266

Query: 388 IKAWIVEKLK-TASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDH 564
             +WI EK +  ASD+  ++  ++Q+ ++KH+    ++AA   ++  + +    L  S  
Sbjct: 267 TISWIKEKGQLMASDDFGRDLASVQALLRKHEGLERDLAAFHHKVKALCAEADRLQQSHP 326

Query: 565 NKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGS 744
             +  IQ + EEL   W+ + + +  +   L  +   Q+F+ +  D+  W+ E+++ + +
Sbjct: 327 INASQIQVKREELIANWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINA 386

Query: 745 DDCGKDLNSVTNLQKKH 795
           D+   D+     L  +H
Sbjct: 387 DELANDVAGAEALLDRH 403


 Score =  112 bits (280), Expect = 1e-24
 Identities = 73/301 (24%), Positives = 140/301 (46%), Gaps = 38/301 (12%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            +R+ + E++    + +R+  + + WI ++EA L N +VG  L+ VE L +K +DF+K L 
Sbjct: 1082 KRKGMLEKSCKKFMLFREANELQQWINEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLK 1141

Query: 187  AQEEKTQRLDDIANKLVENGHYA------------------------------------- 255
            A E + + ++ +AN L   G  A                                     
Sbjct: 1142 ANESRLKDINKVANDLESEGLMAEEVQAVEHQEVYGMMPRDETDSKTVSPWKSARMMVHT 1201

Query: 256  AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDEN 435
             A  N  ++ L  R  +L++ A+ R   L  +   Q F RDADE K WI EK +  + +N
Sbjct: 1202 VATFNSIKE-LNERWRSLQQLAEERSQLLGSADEVQRFHRDADETKEWIEEKNQALNTDN 1260

Query: 436  Y-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKL 612
            Y  +  ++Q+  +  + F  ++AA   +++ +    Q L+ S    ++D+Q++  EL++ 
Sbjct: 1261 YGHDLASVQALQRNDEGFERDLAALGDKVNSLGETAQRLIQSHPELAEDLQEKCTELNQA 1320

Query: 613  WKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
            W  L   +  ++  L  +   Q+F+ +  D+  W+  +   + SD+  KD+     L ++
Sbjct: 1321 WSSLGKRADQRKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380

Query: 793  H 795
            H
Sbjct: 1381 H 1381


 Score =  108 bits (269), Expect = 2e-23
 Identities = 65/263 (24%), Positives = 133/263 (50%), Gaps = 1/263 (0%)
 Frame = +1

Query: 10  RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
           RR   E +   Q F RD ++   WI ++     + +  D   +++  ++KH+ FE  + A
Sbjct: 36  RRQKLEDSYRFQFFQRDADELGKWIQEKLQIASDENYKDP-SNLQGKLQKHQAFEAEVQA 94

Query: 190 QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
                 +LD+  N+++  GH+A+  +  +  +L      L EK + +   L  +     F
Sbjct: 95  NSGAIVKLDETGNQMINEGHFASETIRTRLQELHRLWELLLEKMREKGVKLLQAQKLVQF 154

Query: 370 DRDADEIKAWIVEK-LKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
            R+ +++  WI +K     S+E  ++  +++   +K + F  ++AA+E R+++V      
Sbjct: 155 LRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAGK 214

Query: 547 LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
           L+   H + + I+ + +E++  W+ L   ++ ++  L  A+  Q+F R+V++   W+ E 
Sbjct: 215 LIQEQHPEEELIKSKQDEVNASWQRLKGLAQQRQGKLFGAAEVQRFNRDVDETISWIKEK 274

Query: 727 ESQLGSDDCGKDLNSVTNLQKKH 795
              + SDD G+DL SV  L +KH
Sbjct: 275 GQLMASDDFGRDLASVQALLRKH 297


 Score =  105 bits (263), Expect = 1e-22
 Identities = 66/267 (24%), Positives = 133/267 (49%), Gaps = 3/267 (1%)
 Frame = +1

Query: 4    NERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSL 183
            ++R+     + DLQ F  D     +WI      + ++++   +   EAL+ +H++    +
Sbjct: 1329 DQRKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEI 1388

Query: 184  AAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQ 363
             A+    Q  +    +L+  GHYA+ ++ +K D L   + +LE+    R+  L+     Q
Sbjct: 1389 DARAGTFQAFEQFGQQLLARGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDQCLELQ 1448

Query: 364  LFDRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            LF RD ++ + W+  +    + E+  +   ++++ ++KH++F   I   E +I  ++S  
Sbjct: 1449 LFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAVLQSFA 1508

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
              L+ +DH     I  R  E+   W+ L +    K + L ++   QQF R+V+++E W++
Sbjct: 1509 DQLIAADHYAKGVIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWIS 1568

Query: 721  EVESQLGSDDCGKDLNSV--TNLQKKH 795
            E + Q  SD+  KD  ++  + L  KH
Sbjct: 1569 E-KLQTASDESYKDPTNIQLSKLLSKH 1594


 Score =  102 bits (255), Expect = 9e-22
 Identities = 62/242 (25%), Positives = 128/242 (52%), Gaps = 2/242 (0%)
 Frame = +1

Query: 25   EQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKT 204
            E++++ Q F  + E+ EAWI ++   + + D GD+L +++ L++KHE FE      +++ 
Sbjct: 1872 EESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1931

Query: 205  QRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDAD 384
              +      L++  ++   ++  K   L  + ++LE+ A  RK  L+++  +  F+  AD
Sbjct: 1932 NDVCANGEDLIKKNNHHVENITAKMKGLKGKVSDLEKAAAQRKAKLDENSAFLQFNWKAD 1991

Query: 385  EIKAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAA-NEGRIDDVKSRGQSLLDS 558
             +++WI EK  +   ++Y ++ +++Q+ + K + F A + A  +  I ++ +    LL +
Sbjct: 1992 VVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2051

Query: 559  DHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQL 738
             H +S  I+ R   L K W  L++ S  ++  L +A   Q+  R VED+ +  A+  S  
Sbjct: 2052 KHIQSKAIEVRHASLMKRWNQLLANSAARKKKLLEA---QEHFRKVEDLFLTFAKKASAF 2108

Query: 739  GS 744
             S
Sbjct: 2109 NS 2110


 Score =  100 bits (250), Expect = 4e-21
 Identities = 60/264 (22%), Positives = 132/264 (50%), Gaps = 1/264 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER      +  LQ F  D     +W+ + +A +  +++ + +   EAL+ +H++ +  + 
Sbjct: 352  ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEID 411

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            A E+  +  D+    L+  GHYA+ +V +K   L   ++ L E  +LR+   E   + QL
Sbjct: 412  AHEDSFRSADESGQALLAAGHYASDEVKEKLTILSDERSALLELWELRRQQYEQCMDLQL 471

Query: 367  FDRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
            F RD +++  W+ ++     +E+  +   ++++ ++KH++F   ++A E +I  +     
Sbjct: 472  FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531

Query: 544  SLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE 723
             L+ ++H   DD+  R + L      L   +  +   L  +   QQF R+ ++++ W+ E
Sbjct: 532  KLIQNNHYAMDDVATRRDALLSRRNALHERAMKRRAQLADSFHLQQFFRDSDELKSWVNE 591

Query: 724  VESQLGSDDCGKDLNSVTNLQKKH 795
             + +  +D+  KD +++    +KH
Sbjct: 592  -KMKTATDEAYKDPSNLQGKVQKH 614


 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 65/242 (26%), Positives = 118/242 (48%), Gaps = 5/242 (2%)
 Frame = +1

Query: 31   NMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQR 210
            ++ LQ  +RD E  E WI ++E    + + G  L  V+ L++KH+  +  +A  E + + 
Sbjct: 783  SLRLQQLFRDIEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842

Query: 211  LDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEI 390
            +    N +VE GH+AA DV  K ++L  +  +L+ KA  R+  LEDS   Q +  DA+E 
Sbjct: 843  VTQKGNAMVEEGHFAAEDVKIKLNELNQKWDSLKAKASQRRQDLEDSLQAQQYFADANEA 902

Query: 391  KAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHN 567
            ++W+ EK       +Y K+  + ++ ++KH+  +++++A    I  ++ + QS       
Sbjct: 903  QSWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR----- 957

Query: 568  KSDDIQQRIEELDKLWKDLVSA----SKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQ 735
                 QQ     D+  K+LV A     +     +T   G    + N  + + W  EV  +
Sbjct: 958  -----QQVAPTDDETGKELVLALYDYQEKSpreVTMKKGDILTLLNSTNKDWWKVEVNDR 1012

Query: 736  LG 741
             G
Sbjct: 1013 QG 1014


 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 61/277 (22%), Positives = 129/277 (46%), Gaps = 14/277 (5%)
 Frame = +1

Query: 4    NERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSL 183
            ++RR   E ++  Q ++ D  +A++W+ ++E  + + D G   DS EAL++KHE     L
Sbjct: 880  SQRRQDLEDSLQAQQYFADANEAQSWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDL 939

Query: 184  AAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKA----KLRKGSL--- 342
            +A     Q L + A    +     A   ++   +L++   + +EK+     ++KG +   
Sbjct: 940  SAYGSSIQALREQAQSCRQQ---VAPTDDETGKELVLALYDYQEKSpreVTMKKGDILTL 996

Query: 343  -----EDSHNYQLFDRDADEIKAWI--VEKLKTASDENYKEPTNLQSKVQKHQNFLAEIA 501
                 +D    ++ DR      A++  ++  ++AS EN  E                 IA
Sbjct: 997  LNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQ-------------GSIA 1043

Query: 502  ANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQ 681
              + +ID+     Q+L+  +      +  R++++++L+  L+   + ++  L ++  +  
Sbjct: 1044 LRQEQIDN-----QTLITKE---VGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095

Query: 682  FIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
              R   +++ W+ E E+ L +++ G DL  V  LQKK
Sbjct: 1096 LFREANELQQWINEKEAALTNEEVGADLEQVEVLQKK 1132

>sp|Q13813|SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
            (Alpha-II spectrin) (Fodrin alpha chain)
          Length = 2472

 Score =  315 bits (808), Expect = 7e-86
 Identities = 155/265 (58%), Positives = 198/265 (74%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W  RR  YEQ MDLQLFYRDTEQ + W++KQEAFL N D+GDSLDSVEAL++KHEDFEKS
Sbjct: 456  WELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKS 515

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            L+AQEEK   LD+ A KL++N HYA  DV  +RD LL R+  L E+A  R+  L DS + 
Sbjct: 516  LSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHL 575

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q F RD+DE+K+W+ EK+KTA+DE YK+P+NLQ KVQKHQ F AE++AN+ RID ++  G
Sbjct: 576  QQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAG 635

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
            Q L+D +H   D++  R+ E+  LWK L+ A+++K   L +A+ QQQF RNVED+E+WL 
Sbjct: 636  QKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLY 695

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
            EVE  L SDD GKDL +V NLQKKH
Sbjct: 696  EVEGHLASDDYGKDLTNVQNLQKKH 720


 Score =  249 bits (637), Expect = 5e-66
 Identities = 130/267 (48%), Positives = 177/267 (66%), Gaps = 2/267 (0%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W +RR + +Q ++LQLF+RD EQAE W+A +EAFL   D GDSLDSVEALI+KHEDF+K+
Sbjct: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKA 1493

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            +  QEEK   L   A++L+  GHYA  D++ +R+++L R   L+ +   ++  L +S   
Sbjct: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTL 1553

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q F RD DEI+AWI EKL+TASDE+YK+PTN+QSK QKHQ F AE+ AN  RI  V   G
Sbjct: 1554 QQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMG 1613

Query: 541  QSLLD--SDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIW 714
             SL++  +     D ++ R+  L   W+ LV  S  K   L +A+ QQ F   ++D + W
Sbjct: 1614 NSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFW 1673

Query: 715  LAEVESQLGSDDCGKDLNSVTNLQKKH 795
            L+EVE+ L S+D GKDL SV NL KKH
Sbjct: 1674 LSEVEALLASEDYGKDLASVNNLLKKH 1700


 Score =  147 bits (370), Expect = 4e-35
 Identities = 75/179 (41%), Positives = 111/179 (62%)
 Frame = +1

Query: 256 AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDEN 435
           A D+ ++R  +L R    +E + LR+  LEDS+ +Q F RDA+E++ WI EKL+ ASDEN
Sbjct: 12  AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71

Query: 436 YKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLW 615
           YK+PTNLQ K+QKHQ F AE+ AN G I  +   G  ++   H  S+ I+ R+ EL + W
Sbjct: 72  YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131

Query: 616 KDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
           + L+   + K   L QA    Q++R  ED+  W+ + E+ + S++ G+DL  V  LQKK
Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190


 Score =  142 bits (358), Expect = 1e-33
 Identities = 80/252 (31%), Positives = 137/252 (54%), Gaps = 1/252 (0%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            Q F R+ E  E W+ + E  L ++D G  L +V+ L +KH   E  +AA +++   +   
Sbjct: 681  QQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            A +  + GH+ A ++ KK++ L+ R   L+E    RK  L DS   Q   RD ++ + WI
Sbjct: 741  ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI 800

Query: 403  VEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDD 579
             EK   A+  N  K+   +Q+ ++KHQ   AEIA +E RI  V  +G ++++  H  ++D
Sbjct: 801  REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAED 860

Query: 580  IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGK 759
            ++ ++ EL++ W+ L + +  +  +L  +   QQ+  +  + E W+ E E  +GS D GK
Sbjct: 861  VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGK 920

Query: 760  DLNSVTNLQKKH 795
            D +S   L KKH
Sbjct: 921  DEDSAEALLKKH 932


 Score =  141 bits (355), Expect = 2e-33
 Identities = 79/252 (31%), Positives = 136/252 (53%), Gaps = 1/252 (0%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            Q F    +  + W+++ EA L + D G  L SV  L++KH+  E  ++A E++ + L+  
Sbjct: 1661 QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1720

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            A+ L+ +  +  + V  KRD +  R   ++  A  R+  L +SH    F RD D+ ++WI
Sbjct: 1721 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWI 1780

Query: 403  VEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDD 579
             EK      E+Y ++ T +Q+  +KH+   AE+AA+E  I  V   G+ L D +    ++
Sbjct: 1781 KEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE 1840

Query: 580  IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGK 759
            IQQR+ +  + WK+L   +  +   L ++   QQF+ NVE+ E W+ E  + + S+D G 
Sbjct: 1841 IQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD 1900

Query: 760  DLNSVTNLQKKH 795
             L ++  L KKH
Sbjct: 1901 TLAAIQGLLKKH 1912


 Score =  140 bits (354), Expect = 3e-33
 Identities = 91/265 (34%), Positives = 142/265 (53%), Gaps = 2/265 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER  L     ++Q F+RD ++ + WI ++   L  ++ G  L SV+AL RKHE FE+ LA
Sbjct: 1224 ERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLA 1283

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            A  +K   L + A +L ++   +A D+ +K  +L    ++L ++A  RK  L DSH+ Q 
Sbjct: 1284 ALGDKVNSLGETAERLTQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQR 1343

Query: 367  FDRDADEIKAWI--VEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            F  D  ++ +WI  +  L  +SDE  K+ T  ++ +++HQ    EI A  G     +  G
Sbjct: 1344 FLSDFRDLMSWINGIRGL-VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 1402

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
            Q LL   H  S +I+Q+++ LD+   DL  A   +   L Q    Q F R+ E  E W+A
Sbjct: 1403 QQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMA 1462

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
              E+ L ++D G  L+SV  L KKH
Sbjct: 1463 AREAFLNTEDKGDSLDSVEALIKKH 1487


 Score =  134 bits (337), Expect = 3e-31
 Identities = 76/254 (29%), Positives = 136/254 (53%), Gaps = 1/254 (0%)
 Frame = +1

Query: 37   DLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLD 216
            ++Q F RD ++  +WI ++E  + ++D G  L SV+AL+RKHE  E+ LAA E+K + L 
Sbjct: 256  EVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALC 315

Query: 217  DIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKA 396
              A++L ++   +A  +  KR++L+     +   A  R   L DS+  Q F  D  ++ +
Sbjct: 316  AEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTS 375

Query: 397  WIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKS 573
            W+ E K    +DE   +    ++ + +HQ    EI A+E         GQ+LL + H  S
Sbjct: 376  WVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYAS 435

Query: 574  DDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDC 753
            D++++++  L +    L+   +++     Q    Q F R+ E ++ W+++ E+ L ++D 
Sbjct: 436  DEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDL 495

Query: 754  GKDLNSVTNLQKKH 795
            G  L+SV  L KKH
Sbjct: 496  GDSLDSVEALLKKH 509


 Score =  130 bits (328), Expect = 3e-30
 Identities = 75/263 (28%), Positives = 143/263 (54%), Gaps = 1/263 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR     +  LQ F+RD+++ ++W+ ++     +    D   +++  ++KH+ FE  L+A
Sbjct: 565  RRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP-SNLQGKVQKHQAFEAELSA 623

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
             + +   L+    KL++  HYA  +V  + ++++     L E  +L+   L +++  Q F
Sbjct: 624  NQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQF 683

Query: 370  DRDADEIKAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
            +R+ ++I+ W+ E +   ASD+  K+ TN+Q+  +KH    A++AA++ RID +  + + 
Sbjct: 684  NRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQ 743

Query: 547  LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
              D+ H  +++I+++ E L   ++ L      ++  L  +   QQ  R+VED E W+ E 
Sbjct: 744  FQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK 803

Query: 727  ESQLGSDDCGKDLNSVTNLQKKH 795
            E    S + GKDL  V NL KKH
Sbjct: 804  EPIAASTNRGKDLIGVQNLLKKH 826


 Score =  129 bits (324), Expect = 9e-30
 Identities = 75/262 (28%), Positives = 137/262 (52%), Gaps = 1/262 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR    ++  L  F+RD +  E+WI +++  + + D G  L  V+ L +KH+  E  LAA
Sbjct: 1756 RRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1815

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
             E   Q + D   KL ++      ++ ++    +     L++ A  R   LE+S  YQ F
Sbjct: 1816 HEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQF 1875

Query: 370  DRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
              + +E +AWI EK+   + E+Y +    +Q  ++KH+ F  +   ++ R++DV + GQ 
Sbjct: 1876 VANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQD 1935

Query: 547  LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
            L+  +++  ++I  +++ L+    DL  A+  ++  L + S   QF    + +E W+ E 
Sbjct: 1936 LIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEK 1995

Query: 727  ESQLGSDDCGKDLNSVTNLQKK 792
            E+ L +DD G+DL+SV  L  K
Sbjct: 1996 ENSLKTDDYGRDLSSVQTLLTK 2017


 Score =  117 bits (294), Expect = 3e-26
 Identities = 68/257 (26%), Positives = 131/257 (50%), Gaps = 1/257 (0%)
 Frame = +1

Query: 28  QNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQ 207
           Q   L  + R+ E    WI  +EA + + ++G  L+ VE L +K E+F+  +AA EE+  
Sbjct: 147 QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206

Query: 208 RLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADE 387
            ++  A KL++  H     +  K+D++      L+  A  R+G L  +   Q F+RD DE
Sbjct: 207 EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDE 266

Query: 388 IKAWIVEKLK-TASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDH 564
             +WI EK +  ASD+  ++  ++Q+ ++KH+    ++AA E ++  + +    L  S  
Sbjct: 267 TISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP 326

Query: 565 NKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGS 744
             +  IQ + EEL   W+ + + +  +   L  +   Q+F+ +  D+  W+ E+++ + +
Sbjct: 327 LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINA 386

Query: 745 DDCGKDLNSVTNLQKKH 795
           D+   D+     L  +H
Sbjct: 387 DELASDVAGAEALLDRH 403


 Score =  115 bits (289), Expect = 1e-25
 Identities = 73/301 (24%), Positives = 141/301 (46%), Gaps = 38/301 (12%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            +R+ + E++    + +R+  + + WI ++EA L + +VG  L+ VE L +K +DF+K L 
Sbjct: 1082 KRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLK 1141

Query: 187  AQEEKTQRLDDIANKLVENGHYA------------------------------------- 255
            A E + + ++ +A  L   G  A                                     
Sbjct: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHT 1201

Query: 256  AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDEN 435
             A  N  ++ L  R  +L++ A+ R   L  +H  Q F RDADE K WI EK +  + +N
Sbjct: 1202 VATFNSIKE-LNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN 1260

Query: 436  Y-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKL 612
            Y  +  ++Q+  +KH+ F  ++AA   +++ +    + L  S    ++D+Q++  EL++ 
Sbjct: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLTQSHPESAEDLQEKCTELNQA 1320

Query: 613  WKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
            W  L   +  ++  L  +   Q+F+ +  D+  W+  +   + SD+  KD+     L ++
Sbjct: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380

Query: 793  H 795
            H
Sbjct: 1381 H 1381


 Score =  112 bits (281), Expect = 9e-25
 Identities = 68/265 (25%), Positives = 135/265 (50%), Gaps = 1/265 (0%)
 Frame = +1

Query: 4    NERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSL 183
            ++R+     + DLQ F  D     +WI      + ++++   +   EAL+ +H++    +
Sbjct: 1329 DQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEI 1388

Query: 184  AAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQ 363
             A+    Q  +    +L+ +GHYA+ ++ +K D L   +A+LE+    R+  L+     Q
Sbjct: 1389 DARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQ 1448

Query: 364  LFDRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            LF RD ++ + W+  +    + E+  +   ++++ ++KH++F   I   E +I  +++  
Sbjct: 1449 LFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
              L+ + H    DI  R  E+   W+ L +    K + L ++   QQF R+V+++E W++
Sbjct: 1509 DQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWIS 1568

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
            E + Q  SD+  KD    TN+Q KH
Sbjct: 1569 E-KLQTASDESYKD---PTNIQSKH 1589


 Score =  110 bits (275), Expect = 4e-24
 Identities = 67/263 (25%), Positives = 134/263 (50%), Gaps = 1/263 (0%)
 Frame = +1

Query: 10  RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
           RR   E +   Q F RD E+ E WI ++     + +  D  + ++  ++KH+ FE  + A
Sbjct: 36  RRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTN-LQGKLQKHQAFEAEVQA 94

Query: 190 QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
                 +LD+  N ++  GH+A+  +  +  +L  +   L EK + +   L  +     +
Sbjct: 95  NSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQY 154

Query: 370 DRDADEIKAWIVEK-LKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
            R+ +++  WI +K     S+E  ++  +++   +K + F  ++AA+E R+++V      
Sbjct: 155 LRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAK 214

Query: 547 LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
           L+   H + + I+ + +E++  W+ L   +  ++  L  A+  Q+F R+V++   W+ E 
Sbjct: 215 LIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEK 274

Query: 727 ESQLGSDDCGKDLNSVTNLQKKH 795
           E  + SDD G+DL SV  L +KH
Sbjct: 275 EQLMASDDFGRDLASVQALLRKH 297


 Score =  102 bits (255), Expect = 9e-22
 Identities = 62/242 (25%), Positives = 128/242 (52%), Gaps = 2/242 (0%)
 Frame = +1

Query: 25   EQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKT 204
            E++++ Q F  + E+ EAWI ++   + + D GD+L +++ L++KHE FE      +++ 
Sbjct: 1867 EESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1926

Query: 205  QRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDAD 384
              +      L++  ++   +++ K   L  + ++LE+ A  RK  L+++  +  F+  AD
Sbjct: 1927 NDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKAD 1986

Query: 385  EIKAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAA-NEGRIDDVKSRGQSLLDS 558
             +++WI EK  +   ++Y ++ +++Q+ + K + F A + A  +  I ++ +    LL +
Sbjct: 1987 VVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2046

Query: 559  DHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQL 738
             H +S  I+ R   L K W  L++ S  ++  L +A   Q   R VED+ +  A+  S  
Sbjct: 2047 KHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEA---QSHFRKVEDLFLTFAKKASAF 2103

Query: 739  GS 744
             S
Sbjct: 2104 NS 2105


 Score =  100 bits (248), Expect = 6e-21
 Identities = 60/264 (22%), Positives = 131/264 (49%), Gaps = 1/264 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER      +  LQ F  D     +W+ + +A +  +++   +   EAL+ +H++ +  + 
Sbjct: 352  ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            A E+  +  D+    L+  GHYA+ +V +K   L   +A L E  +LR+   E   + QL
Sbjct: 412  AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471

Query: 367  FDRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
            F RD +++  W+ ++     +E+  +   ++++ ++KH++F   ++A E +I  +     
Sbjct: 472  FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531

Query: 544  SLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE 723
             L+ ++H   +D+  R + L      L   +  +   L  +   QQF R+ ++++ W+ E
Sbjct: 532  KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591

Query: 724  VESQLGSDDCGKDLNSVTNLQKKH 795
             + +  +D+  KD +++    +KH
Sbjct: 592  -KMKTATDEAYKDPSNLQGKVQKH 614


 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 65/242 (26%), Positives = 116/242 (47%), Gaps = 5/242 (2%)
 Frame = +1

Query: 31   NMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQR 210
            ++ LQ  +RD E  E WI ++E    + + G  L  V+ L++KH+  +  +A  E + + 
Sbjct: 783  SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842

Query: 211  LDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEI 390
            +    N +VE GH+AA DV  K  +L  +   L+ KA  R+  LEDS   Q +  DA+E 
Sbjct: 843  VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902

Query: 391  KAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHN 567
            ++W+ EK       +Y K+  + ++ ++KH+  +++++A    I  ++ + QS       
Sbjct: 903  ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR----- 957

Query: 568  KSDDIQQRIEELDKLWKDLVSA----SKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQ 735
                 QQ     D+  K+LV A     +     +T   G    + N  + + W  EV  +
Sbjct: 958  -----QQVAPTDDETGKELVLALYDYQEKSpreVTMKKGDILTLLNSTNKDWWKVEVNDR 1012

Query: 736  LG 741
             G
Sbjct: 1013 QG 1014


 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 62/275 (22%), Positives = 124/275 (45%), Gaps = 12/275 (4%)
 Frame = +1

Query: 4    NERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSL 183
            ++RR   E ++  Q ++ D  +AE+W+ ++E  + + D G   DS EAL++KHE     L
Sbjct: 880  SQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDL 939

Query: 184  AAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKA----KLRKGSL--- 342
            +A     Q L + A    +     A   ++   +L++   + +EK+     ++KG +   
Sbjct: 940  SAYGSSIQALREQAQSCRQQ---VAPTDDETGKELVLALYDYQEKSpreVTMKKGDILTL 996

Query: 343  -----EDSHNYQLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAAN 507
                 +D    ++ DR    + A  V+KL  A   + +     Q  +   Q    E   N
Sbjct: 997  LNSTNKDWWKVEVNDRQG-FVPAAYVKKLDPAQSASRENLLEEQGSIALRQ----EQIDN 1051

Query: 508  EGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFI 687
            + RI                ++  +  R++++++L+  L+   + ++  L ++  +    
Sbjct: 1052 QTRIT--------------KEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLF 1097

Query: 688  RNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
            R   +++ W+ E E+ L S++ G DL  V  LQKK
Sbjct: 1098 REANELQQWINEKEAALTSEEVGADLEQVEVLQKK 1132


 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 50/202 (24%), Positives = 90/202 (44%), Gaps = 38/202 (18%)
 Frame = +1

Query: 304  NLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEK-LKTASDENYKEPTNLQSKVQKHQ 480
            +L E  + RKG LE S    +  R+A+E++ WI EK     S+E   +   ++   +K  
Sbjct: 1075 SLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFD 1134

Query: 481  NFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQ------------------------- 585
            +F  ++ ANE R+ D+    + L +S+   ++++Q                         
Sbjct: 1135 DFQKDLKANESRLKDINKVAEDL-ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWK 1193

Query: 586  ------------QRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVE 729
                          I+EL++ W+ L   ++ +   L  A   Q+F R+ ++ + W+ E  
Sbjct: 1194 SARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKN 1253

Query: 730  SQLGSDDCGKDLNSVTNLQKKH 795
              L +D+ G DL SV  LQ+KH
Sbjct: 1254 QALNTDNYGHDLASVQALQRKH 1275

>sp|P16086|SPTA2_RAT Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
            (Alpha-II spectrin) (Fodrin alpha chain)
          Length = 2472

 Score =  314 bits (804), Expect = 2e-85
 Identities = 154/265 (58%), Positives = 198/265 (74%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W  RR  YEQ MDLQLFYRDTEQ + W++KQEAFL N D+GDSLDSVEAL++KHEDFEKS
Sbjct: 456  WELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKS 515

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            L+AQEEK   LD+ A KL++N HYA  DV  +RD LL R+  L E+A  R+  L DS + 
Sbjct: 516  LSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMHRRAQLADSFHL 575

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q F RD+DE+K+W+ EK+KTA+DE YK+P+NLQ KVQKHQ F AE++AN+ RID ++  G
Sbjct: 576  QQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAG 635

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
            Q L+D +H   +++  R+ E+  LWK L+ A+++K   L +A+ QQQF RNVED+E+WL 
Sbjct: 636  QKLIDVNHYAKEEVAARMNEVISLWKKLLEATELKGVKLREANQQQQFNRNVEDIELWLY 695

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
            EVE  L SDD GKDL +V NLQKKH
Sbjct: 696  EVEGHLASDDYGKDLTNVQNLQKKH 720


 Score =  243 bits (621), Expect = 3e-64
 Identities = 128/267 (47%), Positives = 174/267 (65%), Gaps = 2/267 (0%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W +RR + +  ++LQLF+RD EQAE W+A +EAFL   D GDSLDSVEALI+KHEDF+K+
Sbjct: 1434 WVQRRMMLDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKA 1493

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            +  QEEK   L   A++L+   HYA  D+  +R+++L R   L+ +   ++  L +S   
Sbjct: 1494 INVQEEKIAALQAFADQLIAVDHYAKGDIANRRNEVLDRWRRLKAQMIEKRSKLGESQTL 1553

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q F RD DEI+AWI EKL+TASDE+YK+PTN+QSK QKHQ F AE+ AN  RI  V   G
Sbjct: 1554 QQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMG 1613

Query: 541  QSLLD--SDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIW 714
             SL++  +     D ++ R+  L   W+ LV  S  K   L +A+ QQ F   ++D + W
Sbjct: 1614 NSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFW 1673

Query: 715  LAEVESQLGSDDCGKDLNSVTNLQKKH 795
            L+EVE+ L S+D GKDL SV NL KKH
Sbjct: 1674 LSEVEALLASEDYGKDLASVNNLLKKH 1700


 Score =  147 bits (371), Expect = 3e-35
 Identities = 75/179 (41%), Positives = 111/179 (62%)
 Frame = +1

Query: 256 AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDEN 435
           A D+ ++R  +L R    +E + LR+  LEDS+ +Q F RDA+E++ WI EKL+ ASDEN
Sbjct: 12  AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQVASDEN 71

Query: 436 YKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLW 615
           YK+PTNLQ K+QKHQ F AE+ AN G I  +   G  ++   H  S+ I+ R+ EL + W
Sbjct: 72  YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131

Query: 616 KDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
           + L+   + K   L QA    Q++R  ED+  W+ + E+ + S++ G+DL  V  LQKK
Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190


 Score =  143 bits (361), Expect = 5e-34
 Identities = 80/252 (31%), Positives = 138/252 (54%), Gaps = 1/252 (0%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            Q F    +  + W+++ EA L + D G  L SV  L++KH+  E  ++A E++ + L+  
Sbjct: 1661 QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1720

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            A+ L+ +  +  + V +KRD +  R   ++  A  R+  L +SH    F RD D+ ++WI
Sbjct: 1721 ADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWI 1780

Query: 403  VEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDD 579
             EK    S E+Y ++ T +Q+  +KH+   AE+AA+E  I  V   G+ L D +    ++
Sbjct: 1781 KEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEE 1840

Query: 580  IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGK 759
            IQQR+ +  + WK+L   +  +   L ++   QQF+ NVE+ E W+ E  + + S+D G 
Sbjct: 1841 IQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD 1900

Query: 760  DLNSVTNLQKKH 795
             L ++  L KKH
Sbjct: 1901 TLAAIQGLLKKH 1912


 Score =  142 bits (358), Expect = 1e-33
 Identities = 80/252 (31%), Positives = 137/252 (54%), Gaps = 1/252 (0%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            Q F R+ E  E W+ + E  L ++D G  L +V+ L +KH   E  +AA +++   +   
Sbjct: 681  QQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            A +  + GH+ A ++ KK++ L+ R   L+E    RK  L DS   Q   RD ++ + WI
Sbjct: 741  ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI 800

Query: 403  VEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDD 579
             EK   A+  N  K+   +Q+ ++KHQ   AEIA +E RI  V  +G ++++  H  ++D
Sbjct: 801  REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAED 860

Query: 580  IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGK 759
            ++ ++ EL++ W+ L + +  +  +L  +   QQ+  +  + E W+ E E  +GS D GK
Sbjct: 861  VKAKLSELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGK 920

Query: 760  DLNSVTNLQKKH 795
            D +S   L KKH
Sbjct: 921  DEDSAEALLKKH 932


 Score =  138 bits (348), Expect = 2e-32
 Identities = 89/265 (33%), Positives = 141/265 (53%), Gaps = 2/265 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER  L     ++Q F+RD ++ + WI ++   L  ++ G  L SV+AL RKHE FE+ LA
Sbjct: 1224 ERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLA 1283

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            A  +K   L + A +L+++   +A D+ +K  +L     +L ++A  RK  L DSH+ Q 
Sbjct: 1284 ALGDKVNSLGETAQRLIQSHPESAEDLKEKCTELNQAWTSLGKRADQRKAKLGDSHDLQR 1343

Query: 367  FDRDADEIKAWI--VEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            F  D  ++ +WI  +  L  +SDE  K+ T  ++ +++HQ    EI A  G     +  G
Sbjct: 1344 FLSDFRDLMSWINGIRGL-VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 1402

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
            Q LL   H  S +I+++++ LD+   DL  A   +   L      Q F R+ E  E W+A
Sbjct: 1403 QQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDHCLELQLFHRDCEQAENWMA 1462

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
              E+ L ++D G  L+SV  L KKH
Sbjct: 1463 AREAFLNTEDKGDSLDSVEALIKKH 1487


 Score =  134 bits (336), Expect = 4e-31
 Identities = 76/254 (29%), Positives = 136/254 (53%), Gaps = 1/254 (0%)
 Frame = +1

Query: 37   DLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLD 216
            ++Q F RD ++   WI ++E  + ++D G  L SV+AL+RKHE  E+ LAA E+K + L 
Sbjct: 256  EVQRFNRDVDETIGWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALC 315

Query: 217  DIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKA 396
              A++L ++   +A  +  KR++L+     +   A  R   L+DS+  Q F  D  ++ +
Sbjct: 316  AEADRLQQSHPLSANQIQVKREELITNWEQIRTLAAERHARLDDSYRLQRFLADFRDLTS 375

Query: 397  WIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKS 573
            W+ E K    +DE   +    ++ + +HQ    EI A+E         GQ+LL + H  S
Sbjct: 376  WVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYAS 435

Query: 574  DDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDC 753
            D++++++  L +    L+   +++     Q    Q F R+ E ++ W+++ E+ L ++D 
Sbjct: 436  DEVREKLSILSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDL 495

Query: 754  GKDLNSVTNLQKKH 795
            G  L+SV  L KKH
Sbjct: 496  GDSLDSVEALLKKH 509


 Score =  131 bits (330), Expect = 2e-30
 Identities = 75/263 (28%), Positives = 143/263 (54%), Gaps = 1/263 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR     +  LQ F+RD+++ ++W+ ++     +    D   +++  ++KH+ FE  L+A
Sbjct: 565  RRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP-SNLQGKVQKHQAFEAELSA 623

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
             + +   L+    KL++  HYA  +V  + ++++     L E  +L+   L +++  Q F
Sbjct: 624  NQSRIDALEKAGQKLIDVNHYAKEEVAARMNEVISLWKKLLEATELKGVKLREANQQQQF 683

Query: 370  DRDADEIKAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
            +R+ ++I+ W+ E +   ASD+  K+ TN+Q+  +KH    A++AA++ RID +  + + 
Sbjct: 684  NRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQ 743

Query: 547  LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
              D+ H  +++I+++ E L   ++ L      ++  L  +   QQ  R+VED E W+ E 
Sbjct: 744  FQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK 803

Query: 727  ESQLGSDDCGKDLNSVTNLQKKH 795
            E    S + GKDL  V NL KKH
Sbjct: 804  EPIAASTNRGKDLIGVQNLLKKH 826


 Score =  130 bits (326), Expect = 5e-30
 Identities = 75/262 (28%), Positives = 137/262 (52%), Gaps = 1/262 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR    ++  L  F+RD +  E+WI +++  + + D G  L  V+ L +KH+  E  LAA
Sbjct: 1756 RRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAA 1815

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
             E   Q + D   KL ++      ++ ++    +     L++ A  R   LE+S  YQ F
Sbjct: 1816 HEPAIQGVLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQF 1875

Query: 370  DRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
              + +E +AWI EK+   + E+Y +    +Q  ++KH+ F  +   ++ R++DV + GQ 
Sbjct: 1876 VANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQD 1935

Query: 547  LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
            L+  +++  ++I  +++ L+    DL  A+  ++  L + S   QF    + +E W+ E 
Sbjct: 1936 LIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEK 1995

Query: 727  ESQLGSDDCGKDLNSVTNLQKK 792
            E+ L +DD G+DL+SV  L  K
Sbjct: 1996 ENSLKTDDYGRDLSSVQTLLTK 2017


 Score =  117 bits (292), Expect = 5e-26
 Identities = 68/257 (26%), Positives = 131/257 (50%), Gaps = 1/257 (0%)
 Frame = +1

Query: 28  QNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQ 207
           Q   L  + R+ E    WI  +EA + + ++G  L+ VE L +K E+F+  LAA EE+  
Sbjct: 147 QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVN 206

Query: 208 RLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADE 387
            ++  A KL++  H     +  K++++      L+  A  R+G L  +   Q F+RD DE
Sbjct: 207 EVNQFAAKLIQEQHPEEELIKTKQEEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDE 266

Query: 388 IKAWIVEKLK-TASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDH 564
              WI EK +  ASD+  ++  ++Q+ ++KH+    ++AA E ++  + +    L  S  
Sbjct: 267 TIGWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP 326

Query: 565 NKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGS 744
             ++ IQ + EEL   W+ + + +  +   L  +   Q+F+ +  D+  W+ E+++ + +
Sbjct: 327 LSANQIQVKREELITNWEQIRTLAAERHARLDDSYRLQRFLADFRDLTSWVTEMKALINA 386

Query: 745 DDCGKDLNSVTNLQKKH 795
           D+   D+     L  +H
Sbjct: 387 DELANDVAGAEALLDRH 403


 Score =  116 bits (290), Expect = 8e-26
 Identities = 73/301 (24%), Positives = 142/301 (47%), Gaps = 38/301 (12%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            +R+ + E++    + +R+  + + WI ++EA L + +VG  L+ VE L +K +DF+K L 
Sbjct: 1082 KRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLK 1141

Query: 187  AQEEKTQRLDDIANKLVENGHYA------------------------------------- 255
            A E + + ++ +A  L   G  A                                     
Sbjct: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDEADSKTASPWKSARLMVHT 1201

Query: 256  AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDEN 435
             A  N  ++ L  R  +L++ A+ R   L  +H  Q F RDADE K WI EK +  + +N
Sbjct: 1202 VATFNSIKE-LNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN 1260

Query: 436  Y-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKL 612
            Y  +  ++Q+  +KH+ F  ++AA   +++ +    Q L+ S    ++D++++  EL++ 
Sbjct: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDLKEKCTELNQA 1320

Query: 613  WKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
            W  L   +  ++  L  +   Q+F+ +  D+  W+  +   + SD+  KD+     L ++
Sbjct: 1321 WTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380

Query: 793  H 795
            H
Sbjct: 1381 H 1381


 Score =  112 bits (279), Expect = 2e-24
 Identities = 68/265 (25%), Positives = 134/265 (50%), Gaps = 1/265 (0%)
 Frame = +1

Query: 4    NERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSL 183
            ++R+     + DLQ F  D     +WI      + ++++   +   EAL+ +H++    +
Sbjct: 1329 DQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEI 1388

Query: 184  AAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQ 363
             A+    Q  +    +L+ +GHYA+ ++ +K D L   + +LE+    R+  L+     Q
Sbjct: 1389 DARAGTFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDHCLELQ 1448

Query: 364  LFDRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            LF RD ++ + W+  +    + E+  +   ++++ ++KH++F   I   E +I  +++  
Sbjct: 1449 LFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
              L+  DH    DI  R  E+   W+ L +    K + L ++   QQF R+V+++E W++
Sbjct: 1509 DQLIAVDHYAKGDIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWIS 1568

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
            E + Q  SD+  KD    TN+Q KH
Sbjct: 1569 E-KLQTASDESYKD---PTNIQSKH 1589


 Score =  110 bits (276), Expect = 3e-24
 Identities = 68/263 (25%), Positives = 134/263 (50%), Gaps = 1/263 (0%)
 Frame = +1

Query: 10  RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
           RR   E +   Q F RD E+ E WI ++     + +  D  + ++  ++KH+ FE  + A
Sbjct: 36  RRQKLEDSYRFQFFQRDAEELEKWIQEKLQVASDENYKDPTN-LQGKLQKHQAFEAEVQA 94

Query: 190 QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
                 +LD+  N ++  GH+A+  +  +  +L  +   L EK + +   L  +     +
Sbjct: 95  NSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQY 154

Query: 370 DRDADEIKAWIVEK-LKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
            R+ +++  WI +K     S+E  ++  +++   +K + F  ++AA+E R+++V      
Sbjct: 155 LRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAAK 214

Query: 547 LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
           L+   H + + I+ + EE++  W+ L   +  ++  L  A+  Q+F R+V++   W+ E 
Sbjct: 215 LIQEQHPEEELIKTKQEEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIGWIKEK 274

Query: 727 ESQLGSDDCGKDLNSVTNLQKKH 795
           E  + SDD G+DL SV  L +KH
Sbjct: 275 EQLMASDDFGRDLASVQALLRKH 297


 Score =  102 bits (254), Expect = 1e-21
 Identities = 62/242 (25%), Positives = 128/242 (52%), Gaps = 2/242 (0%)
 Frame = +1

Query: 25   EQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKT 204
            E++++ Q F  + E+ EAWI ++   + + D GD+L +++ L++KHE FE      +++ 
Sbjct: 1867 EESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1926

Query: 205  QRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDAD 384
              +      L++  ++   +++ K   L  + ++LE+ A  RK  L+++  +  F+  AD
Sbjct: 1927 NDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKAD 1986

Query: 385  EIKAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAA-NEGRIDDVKSRGQSLLDS 558
             +++WI EK  +   ++Y ++ +++Q+ + K + F A + A  +  I ++ +    LL +
Sbjct: 1987 VVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2046

Query: 559  DHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQL 738
             H +S  I+ R   L K W  L++ S  ++  L +A   Q   R VED+ +  A+  S  
Sbjct: 2047 KHIQSKAIEARHASLMKRWTQLLANSATRKKKLLEA---QSHFRKVEDLFLTFAKKASAF 2103

Query: 739  GS 744
             S
Sbjct: 2104 NS 2105


 Score =  101 bits (252), Expect = 2e-21
 Identities = 60/264 (22%), Positives = 133/264 (50%), Gaps = 1/264 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER    + +  LQ F  D     +W+ + +A +  +++ + +   EAL+ +H++ +  + 
Sbjct: 352  ERHARLDDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEID 411

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            A E+  +  D+    L+  GHYA+ +V +K   L   +A L E  +LR+   E   + QL
Sbjct: 412  AHEDSFKSADESGQALLAAGHYASDEVREKLSILSEERAALLELWELRRQQYEQCMDLQL 471

Query: 367  FDRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
            F RD +++  W+ ++     +E+  +   ++++ ++KH++F   ++A E +I  +     
Sbjct: 472  FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531

Query: 544  SLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE 723
             L+ ++H   +D+  R + L      L   +  +   L  +   QQF R+ ++++ W+ E
Sbjct: 532  KLIQNNHYAMEDVATRRDALLSRRNALHERAMHRRAQLADSFHLQQFFRDSDELKSWVNE 591

Query: 724  VESQLGSDDCGKDLNSVTNLQKKH 795
             + +  +D+  KD +++    +KH
Sbjct: 592  -KMKTATDEAYKDPSNLQGKVQKH 614


 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 65/242 (26%), Positives = 116/242 (47%), Gaps = 5/242 (2%)
 Frame = +1

Query: 31   NMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQR 210
            ++ LQ  +RD E  E WI ++E    + + G  L  V+ L++KH+  +  +A  E + + 
Sbjct: 783  SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842

Query: 211  LDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEI 390
            +    N +VE GH+AA DV  K  +L  +   L+ KA  R+  LEDS   Q +  DA+E 
Sbjct: 843  VTQKGNAMVEEGHFAAEDVKAKLSELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902

Query: 391  KAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHN 567
            ++W+ EK       +Y K+  + ++ ++KH+  +++++A    I  ++ + QS       
Sbjct: 903  ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR----- 957

Query: 568  KSDDIQQRIEELDKLWKDLVSA----SKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQ 735
                 QQ     D+  K+LV A     +     +T   G    + N  + + W  EV  +
Sbjct: 958  -----QQVAPMDDETGKELVLALYDYQEKSpreVTMKKGDILTLLNSTNKDWWKVEVNDR 1012

Query: 736  LG 741
             G
Sbjct: 1013 QG 1014


 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 63/277 (22%), Positives = 131/277 (47%), Gaps = 14/277 (5%)
 Frame = +1

Query: 4    NERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSL 183
            ++RR   E ++  Q ++ D  +AE+W+ ++E  + + D G   DS EAL++KHE     L
Sbjct: 880  SQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDL 939

Query: 184  AAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKA----KLRKGSL--- 342
            +A     Q L + A    +     A   ++   +L++   + +EK+     ++KG +   
Sbjct: 940  SAYGSSIQALREQAQSCRQQ---VAPMDDETGKELVLALYDYQEKSpreVTMKKGDILTL 996

Query: 343  -----EDSHNYQLFDRDADEIKAWI--VEKLKTASDENYKEPTNLQSKVQKHQNFLAEIA 501
                 +D    ++ DR      A++  ++  ++AS EN  E                 IA
Sbjct: 997  LNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQ-------------GSIA 1043

Query: 502  ANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQ 681
              +G+ID+     Q+ +  +   +  +  R++++++L++ L+   + ++  L ++  +  
Sbjct: 1044 LRQGQIDN-----QTRITKE---AGSVSLRMKQVEELYQSLLELGEKRKGMLEKSCKKFM 1095

Query: 682  FIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
              R   +++ W+ E E+ L S++ G DL  V  LQKK
Sbjct: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKK 1132

>sp|P16546|SPTA2_MOUSE Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
            (Alpha-II spectrin) (Fodrin alpha chain)
          Length = 1458

 Score =  243 bits (621), Expect = 3e-64
 Identities = 128/267 (47%), Positives = 174/267 (65%), Gaps = 2/267 (0%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W +RR + +  ++LQLF+RD EQAE W+A +EAFL   D GDSLDSVEALI+KHEDF+K+
Sbjct: 420  WVQRRMMLDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKA 479

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            +  QEEK   L   A++L+   HYA  D+  +R+++L R   L+ +   ++  L +S   
Sbjct: 480  INVQEEKIAALQAFADQLIAVDHYAKGDIANRRNEVLDRWRRLKAQMIEKRSKLGESQTL 539

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q F RD DEI+AWI EKL+TASDE+YK+PTN+QSK QKHQ F AE+ AN  RI  V   G
Sbjct: 540  QQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMG 599

Query: 541  QSLLD--SDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIW 714
             SL++  +     D ++ R+  L   W+ LV  S  K   L +A+ QQ F   ++D + W
Sbjct: 600  NSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFW 659

Query: 715  LAEVESQLGSDDCGKDLNSVTNLQKKH 795
            L+EVE+ L S+D GKDL SV NL KKH
Sbjct: 660  LSEVEALLASEDYGKDLASVNNLLKKH 686


 Score =  143 bits (361), Expect = 5e-34
 Identities = 80/252 (31%), Positives = 138/252 (54%), Gaps = 1/252 (0%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            Q F    +  + W+++ EA L + D G  L SV  L++KH+  E  ++A E++ + L+  
Sbjct: 647  QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 706

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            A+ L+ +  +  + V +KRD +  R   ++  A  R+  L +SH    F RD D+ ++WI
Sbjct: 707  ADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWI 766

Query: 403  VEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDD 579
             EK    S E+Y ++ T +Q+  +KH+   AE+AA+E  I  V   G+ L D +    ++
Sbjct: 767  KEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEE 826

Query: 580  IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGK 759
            IQQR+ +  + WK+L   +  +   L ++   QQF+ NVE+ E W+ E  + + S+D G 
Sbjct: 827  IQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD 886

Query: 760  DLNSVTNLQKKH 795
             L ++  L KKH
Sbjct: 887  TLAAIQGLLKKH 898


 Score =  138 bits (348), Expect = 2e-32
 Identities = 89/265 (33%), Positives = 141/265 (53%), Gaps = 2/265 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER  L     ++Q F+RD ++ + WI ++   L  ++ G  L SV+AL RKHE FE+ LA
Sbjct: 210  ERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLA 269

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            A  +K   L + A +L+++   +A D+ +K  +L     +L ++A  RK  L DSH+ Q 
Sbjct: 270  ALGDKVNSLGETAQRLIQSHPESAEDLKEKCTELNQAWTSLGKRADQRKAKLGDSHDLQR 329

Query: 367  FDRDADEIKAWI--VEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            F  D  ++ +WI  +  L  +SDE  K+ T  ++ +++HQ    EI A  G     +  G
Sbjct: 330  FLSDFRDLMSWINGIRGL-VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 388

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
            Q LL   H  S +I+++++ LD+   DL  A   +   L      Q F R+ E  E W+A
Sbjct: 389  QQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDHCLELQLFHRDCEQAENWMA 448

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
              E+ L ++D G  L+SV  L KKH
Sbjct: 449  AREAFLNTEDKGDSLDSVEALIKKH 473


 Score =  130 bits (326), Expect = 5e-30
 Identities = 75/262 (28%), Positives = 137/262 (52%), Gaps = 1/262 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR    ++  L  F+RD +  E+WI +++  + + D G  L  V+ L +KH+  E  LAA
Sbjct: 742  RRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAA 801

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
             E   Q + D   KL ++      ++ ++    +     L++ A  R   LE+S  YQ F
Sbjct: 802  HEPAIQGVLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQF 861

Query: 370  DRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
              + +E +AWI EK+   + E+Y +    +Q  ++KH+ F  +   ++ R++DV + GQ 
Sbjct: 862  VANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQD 921

Query: 547  LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
            L+  +++  ++I  +++ L+    DL  A+  ++  L + S   QF    + +E W+ E 
Sbjct: 922  LIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEK 981

Query: 727  ESQLGSDDCGKDLNSVTNLQKK 792
            E+ L +DD G+DL+SV  L  K
Sbjct: 982  ENSLKTDDYGRDLSSVQTLLTK 1003


 Score =  119 bits (297), Expect = 1e-26
 Identities = 74/301 (24%), Positives = 142/301 (47%), Gaps = 38/301 (12%)
 Frame = +1

Query: 7   ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
           +R+ + E++    + +R+  + + WI ++EA L N +VG  L+ VE L +K +DF+K L 
Sbjct: 68  KRKGMLEKSCKKFMLFREANELQQWITEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLK 127

Query: 187 AQEEKTQRLDDIANKLVENGHYA------------------------------------- 255
           A E + + ++ +A  L   G  A                                     
Sbjct: 128 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGAMPRDEADSKTASPWKSARLMVHT 187

Query: 256 AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDEN 435
            A  N  ++ L  R  +L++ A+ R   L  +H  Q F RDADE K WI EK +  + +N
Sbjct: 188 VATFNSIKE-LNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN 246

Query: 436 Y-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKL 612
           Y  +  ++Q+  +KH+ F  ++AA   +++ +    Q L+ S    ++D++++  EL++ 
Sbjct: 247 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDLKEKCTELNQA 306

Query: 613 WKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
           W  L   +  ++  L  +   Q+F+ +  D+  W+  +   + SD+  KD+     L ++
Sbjct: 307 WTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 366

Query: 793 H 795
           H
Sbjct: 367 H 367


 Score =  112 bits (279), Expect = 2e-24
 Identities = 68/265 (25%), Positives = 134/265 (50%), Gaps = 1/265 (0%)
 Frame = +1

Query: 4    NERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSL 183
            ++R+     + DLQ F  D     +WI      + ++++   +   EAL+ +H++    +
Sbjct: 315  DQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEI 374

Query: 184  AAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQ 363
             A+    Q  +    +L+ +GHYA+ ++ +K D L   + +LE+    R+  L+     Q
Sbjct: 375  DARAGTFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDHCLELQ 434

Query: 364  LFDRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            LF RD ++ + W+  +    + E+  +   ++++ ++KH++F   I   E +I  +++  
Sbjct: 435  LFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 494

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
              L+  DH    DI  R  E+   W+ L +    K + L ++   QQF R+V+++E W++
Sbjct: 495  DQLIAVDHYAKGDIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWIS 554

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
            E + Q  SD+  KD    TN+Q KH
Sbjct: 555  E-KLQTASDESYKD---PTNIQSKH 575


 Score =  102 bits (254), Expect = 1e-21
 Identities = 62/242 (25%), Positives = 128/242 (52%), Gaps = 2/242 (0%)
 Frame = +1

Query: 25   EQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKT 204
            E++++ Q F  + E+ EAWI ++   + + D GD+L +++ L++KHE FE      +++ 
Sbjct: 853  EESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 912

Query: 205  QRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDAD 384
              +      L++  ++   +++ K   L  + ++LE+ A  RK  L+++  +  F+  AD
Sbjct: 913  NDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKAD 972

Query: 385  EIKAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAA-NEGRIDDVKSRGQSLLDS 558
             +++WI EK  +   ++Y ++ +++Q+ + K + F A + A  +  I ++ +    LL +
Sbjct: 973  VVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 1032

Query: 559  DHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQL 738
             H +S  I+ R   L K W  L++ S  ++  L +A   Q   R VED+ +  A+  S  
Sbjct: 1033 KHIQSKAIEARHASLMKRWTQLLANSATRKKKLLEA---QSHFRKVEDLFLTFAKKASAF 1089

Query: 739  GS 744
             S
Sbjct: 1090 NS 1091


 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 49/202 (24%), Positives = 90/202 (44%), Gaps = 38/202 (18%)
 Frame = +1

Query: 304 NLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDENY-KEPTNLQSKVQKHQ 480
           +L E  + RKG LE S    +  R+A+E++ WI EK    ++E    +   ++   +K  
Sbjct: 61  SLLELGEKRKGMLEKSCKKFMLFREANELQQWITEKEAALTNEEVGADLEQVEVLQKKFD 120

Query: 481 NFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQ------------------------- 585
           +F  ++ ANE R+ D+    +  L+S+   ++++Q                         
Sbjct: 121 DFQKDLKANESRLKDINKVAED-LESEGLMAEEVQAVQQQEVYGAMPRDEADSKTASPWK 179

Query: 586 ------------QRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVE 729
                         I+EL++ W+ L   ++ +   L  A   Q+F R+ ++ + W+ E  
Sbjct: 180 SARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKN 239

Query: 730 SQLGSDDCGKDLNSVTNLQKKH 795
             L +D+ G DL SV  LQ+KH
Sbjct: 240 QALNTDNYGHDLASVQALQRKH 261


 Score = 37.4 bits (85), Expect = 0.048
 Identities = 26/110 (23%), Positives = 52/110 (47%)
 Frame = +1

Query: 463 KVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKI 642
           +V   Q F+   AA   ++D  +S  +  L  +      I  R  ++D  ++ L+   + 
Sbjct: 14  EVNDRQGFVP--AAYVKKLDPAQSASRENLLEEQGS---IALRQGQIDNQYQSLLELGEK 68

Query: 643 KETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
           ++  L ++  +    R   +++ W+ E E+ L +++ G DL  V  LQKK
Sbjct: 69  RKGMLEKSCKKFMLFREANELQQWITEKEAALTNEEVGADLEQVEVLQKK 118

>sp|P02549|SPTA1_HUMAN Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin)
          Length = 2418

 Score =  241 bits (615), Expect = 2e-63
 Identities = 119/265 (44%), Positives = 178/265 (67%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W+ER   YEQ +D  LFYRD+EQ ++W+++QEAFLEN D+G+SL S EAL++KHEDFE++
Sbjct: 465  WDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEA 524

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
              AQEEK   +D  A KL+ + HY + ++   RD LL R+  L EKA  R+  L++S   
Sbjct: 525  FTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLL 584

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q    D+D++K WI +K K A DE+YK+  NL+S+VQK Q F  E+A N+ ++++++  G
Sbjct: 585  QKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTG 644

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
            Q +++  H  SD++  R+ E+  LW++L+ A+K K T L +A+ Q QF  N ED++ WL 
Sbjct: 645  QEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLE 704

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
            +VE Q+ S+D GK L  V N  +KH
Sbjct: 705  DVEWQVTSEDYGKGLAEVQNRLRKH 729


 Score =  166 bits (420), Expect = 7e-41
 Identities = 92/266 (34%), Positives = 153/266 (57%), Gaps = 1/266 (0%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W +R+ + +Q ++LQ+F  + +Q E+ +  +E  L ++D   SLDS+EAL++K +D +K+
Sbjct: 1384 WEKRKKILDQCLELQMFQGNCDQVESRMVARENSLRSDDKS-SLDSLEALMKKRDDLDKA 1442

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            + AQE K   L+  A  L+ + HYA  ++  +   +L R   L+ +    +  L D  N 
Sbjct: 1443 ITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANL 1502

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            + F RD +E++ WI E L TA DE+YK+ TN+Q K  KHQ F  E+     ++  V + G
Sbjct: 1503 KQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLG 1562

Query: 541  QSLLD-SDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWL 717
             SL++ S     + +++++E+L + W  L+  +  K   L +AS QQ+F  ++ D E WL
Sbjct: 1563 NSLIERSCDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWL 1622

Query: 718  AEVESQLGSDDCGKDLNSVTNLQKKH 795
            +E E+ L   D  +DL S  NL KKH
Sbjct: 1623 SEAETLLAMKDQARDLASAGNLLKKH 1648


 Score =  117 bits (292), Expect = 5e-26
 Identities = 72/256 (28%), Positives = 126/256 (49%), Gaps = 3/256 (1%)
 Frame = +1

Query: 37   DLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLD 216
            +LQ F RD  +A  WI ++E  L + D G  L + E L   H+  E++LA   +K + L 
Sbjct: 265  NLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELC 324

Query: 217  DIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKA 396
              A KL  +    A  + + ++DL+    ++   A  R   L+ ++ Y  F  D DE+  
Sbjct: 325  AKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSG 384

Query: 397  WIVEKLKTASDENYKEPTNL---QSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHN 567
            W+ E  KTA+    + PT++   +  + +HQ    EI + + R       GQ L++++H 
Sbjct: 385  WMNE--KTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHE 442

Query: 568  KSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSD 747
             SD++++++E LD  W  L+     +     Q      F R+ E ++ W++  E+ L ++
Sbjct: 443  ASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENE 502

Query: 748  DCGKDLNSVTNLQKKH 795
            D G  L S   L +KH
Sbjct: 503  DLGNSLGSAEALLQKH 518


 Score =  117 bits (292), Expect = 5e-26
 Identities = 73/261 (27%), Positives = 135/261 (51%), Gaps = 2/261 (0%)
 Frame = +1

Query: 19   LYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEE 198
            L+E N  LQ F  + E  + W+   E  + + D G  L  V+  +RKH   E ++AA+++
Sbjct: 683  LHEANQQLQ-FENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQD 741

Query: 199  KTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRD 378
            +   L D+A    E GH  + D+  +++ L+ R   L+E    RK  L D  + QL  RD
Sbjct: 742  QVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRD 801

Query: 379  ADEIKAWIVEKLKTASDENYKEPTNLQSK--VQKHQNFLAEIAANEGRIDDVKSRGQSLL 552
             ++ +AWI E   +A+   Y     + SK  + +H+  L  IA++E RI ++  RG  ++
Sbjct: 802  TEDEEAWIQETEPSAT-STYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMV 860

Query: 553  DSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVES 732
            +  H  ++D+  R++ L++  + L + +  ++ +L      QQ++ ++ + E W+ E E 
Sbjct: 861  EEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEP 920

Query: 733  QLGSDDCGKDLNSVTNLQKKH 795
             + + + G D  +   L KKH
Sbjct: 921  IVDNTNYGADEEAAGALLKKH 941


 Score =  117 bits (292), Expect = 5e-26
 Identities = 68/252 (26%), Positives = 128/252 (50%), Gaps = 1/252 (0%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            Q F       E W+++ E  L   D    L S   L++KH+  E+ + A+E+  + L+ +
Sbjct: 1609 QRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTL 1668

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            A  L+ +G +    + KK+D++  R  N++E A      L++++    F +D D+ ++WI
Sbjct: 1669 AEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWI 1728

Query: 403  VEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDD 579
             EKL   S ++Y ++   +Q+ ++KH+    E+ A+E  I +V    + L D      ++
Sbjct: 1729 EEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE 1788

Query: 580  IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGK 759
            IQ R+ +  + W+ L   +K +   L ++    QF++N E+ E W+ E  +     DCG 
Sbjct: 1789 IQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGD 1848

Query: 760  DLNSVTNLQKKH 795
             L +  +L  KH
Sbjct: 1849 TLAATQSLLMKH 1860


 Score =  114 bits (285), Expect = 3e-25
 Identities = 58/263 (22%), Positives = 135/263 (51%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            +R+    +     LF       + WI+     + + ++ + L  +E L+ +H++    + 
Sbjct: 1280 DRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADME 1339

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            A+    Q L+D + +L+++GH+A+ ++ KK   + + + +LE+  + RK  L+     Q+
Sbjct: 1340 AEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQM 1399

Query: 367  FDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
            F  + D++++ +V +  +   ++     +L++ ++K  +    I A EG+I D++   +S
Sbjct: 1400 FQGNCDQVESRMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAES 1459

Query: 547  LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
            L+  +H   ++I  R++ +   WK L +    + T L   +  +QF R++E++E W++E+
Sbjct: 1460 LIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM 1519

Query: 727  ESQLGSDDCGKDLNSVTNLQKKH 795
                    C +     TN+Q+K+
Sbjct: 1520 LPTA----CDESYKDATNIQRKY 1538


 Score =  109 bits (273), Expect = 8e-24
 Identities = 55/179 (30%), Positives = 100/179 (55%)
 Frame = +1

Query: 256 AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDEN 435
           A ++ ++R ++L R  + +E+   R   LEDS++ Q+F RDAD++  WI+EK+   +D++
Sbjct: 21  AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80

Query: 436 YKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLW 615
           Y++PTN+Q K QKHQ+  AE+      + +++   +      H+  ++ +  IEEL  LW
Sbjct: 81  YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLW 140

Query: 616 KDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
             L+  +  K   L +A   QQ+++   D+  W+ + E+   S + G+D      L KK
Sbjct: 141 DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKK 199


 Score =  101 bits (252), Expect = 2e-21
 Identities = 68/254 (26%), Positives = 124/254 (48%), Gaps = 4/254 (1%)
 Frame = +1

Query: 49   FYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDIAN 228
            F++D +  E+WI ++   + + D G  L  V+ L++KH+  E  L A E   Q + D+A 
Sbjct: 1717 FFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAE 1776

Query: 229  KLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVE 408
            KL +       ++  +    +     L+E AK R   LE+S  Y  F ++A+E +AWI E
Sbjct: 1777 KLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINE 1836

Query: 409  KLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDS---DHNKSD 576
            K   A   +  +     QS + KH+    + A +E R+ +V ++G+ +L+    + +++ 
Sbjct: 1837 KNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLHEESQNK 1896

Query: 577  DIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCG 756
            +I  +IE L++    L  A    +  L      Q+F    + +E W+A+ E+ L ++  G
Sbjct: 1897 EISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNG 1956

Query: 757  KDLNSVTNLQKKHN 798
             DL     L  K +
Sbjct: 1957 ADLGDFLTLLAKQD 1970


 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 72/266 (27%), Positives = 134/266 (50%), Gaps = 1/266 (0%)
 Frame = +1

Query: 4    NERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSL 183
            +E+R L      +++F+R+ +  +  I K+   L   D G  L SV+AL R+HE FE+ L
Sbjct: 1173 DEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDL 1232

Query: 184  AAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQ 363
                +K   L + A +L E+   A  D+ +++ +L     +L+ + K RK SL ++  + 
Sbjct: 1233 VPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFY 1292

Query: 364  LFDRDADEIKAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            LF   A +++ WI       +S E  ++ T ++  +++HQ   A++ A       ++   
Sbjct: 1293 LFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFS 1352

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
              L+DS H+ S +I+++++ +     DL  A + ++  L Q    Q F  N + +E  + 
Sbjct: 1353 AELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESRMV 1412

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKHN 798
              E+ L SDD    L+S+  L KK +
Sbjct: 1413 ARENSLRSDD-KSSLDSLEALMKKRD 1437


 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 71/273 (26%), Positives = 128/273 (46%), Gaps = 16/273 (5%)
 Frame = +1

Query: 25   EQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKT 204
            E++++   F ++ E+ EAWI ++ A     D GD+L + ++L+ KHE  E   A  E + 
Sbjct: 1815 EESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRV 1874

Query: 205  QRL----DDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFD 372
            Q +    +DI NK++        +++ K + L  +  +L +     K  LED + +Q F+
Sbjct: 1875 QNVCAQGEDILNKVLHE-ESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFN 1933

Query: 373  RDADEIKAWIVEK---LKTASDENYKEPTNLQSKVQKHQNFLAEIAA-NEGRIDDVKSRG 540
              AD ++AWI +K   LKT  + N  +  +  + + K     A + +  + R+ ++    
Sbjct: 1934 WKADVVEAWIADKETSLKT--NGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLK 1991

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSAS-----KIKETNLTQASGQQ---QFIRNV 696
              L+ + HN+S  I++R   L K W+ L+ AS     K+ E  L     +    +F    
Sbjct: 1992 DKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKA 2051

Query: 697  EDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKH 795
              +  W  ++E  L        LN +  LQK H
Sbjct: 2052 SALNNWCEKMEENLSEPVHCVSLNEIRQLQKDH 2084


 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 54/255 (21%), Positives = 114/255 (44%), Gaps = 1/255 (0%)
 Frame = +1

Query: 34  MDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRL 213
           +  Q + ++      WI  +EA   + ++G+  +  E L +K EDF+  L A+E +   +
Sbjct: 158 LKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEV 217

Query: 214 DDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIK 393
           +  AN+  E  H     +  K++++      L   A  R+ +L ++ N Q F RD  E  
Sbjct: 218 NQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAI 277

Query: 394 AWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNK 570
            WI EK    + E+Y K+    +     H+     +A    ++ ++ ++ + L  S  + 
Sbjct: 278 QWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSD 337

Query: 571 SDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDD 750
           +  IQ+  E+L   W+ + + +  +   L       +F  + +++  W+ E  + + +D+
Sbjct: 338 APQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADE 397

Query: 751 CGKDLNSVTNLQKKH 795
              D+     L  +H
Sbjct: 398 LPTDVAGGEVLLDRH 412


 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 48/156 (30%), Positives = 81/156 (51%), Gaps = 1/156 (0%)
 Frame = +1

Query: 34   MDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRL 213
            + LQL  RDTE  EAWI + E    +  +G  L + + L+ +H    +++A+ E + Q +
Sbjct: 793  LHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEI 852

Query: 214  DDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIK 393
             +  NK+VE GH+AA DV  +   L     +L  +A  R+  LE +  +Q +  D  E +
Sbjct: 853  TERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAE 912

Query: 394  AWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEI 498
             WI EK     + NY  +     + ++KH+ FL ++
Sbjct: 913  TWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDL 948


 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 65/265 (24%), Positives = 117/265 (44%), Gaps = 2/265 (0%)
 Frame = +1

Query: 7   ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
           ER    E +  LQ+F RD +    WI ++   L +    D   +++   +KH+  E  + 
Sbjct: 44  ERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDP-TNIQGKYQKHQSLEAEVQ 102

Query: 187 AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKG-SLEDSHNYQ 363
            +      L+    +    GH +A +  K   + L    +L  +  L KG  L  +  +Q
Sbjct: 103 TKSRLMSELEKTREERFTMGH-SAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQ 161

Query: 364 LFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKV-QKHQNFLAEIAANEGRIDDVKSRG 540
            + ++  +I  WI +K   A+     E       + +K ++F  E+ A EGR+ +V    
Sbjct: 162 QYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYA 221

Query: 541 QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
               + +H     IQ +  E++  W+ L   +  ++  L+ A+  Q+F R+V +   W+ 
Sbjct: 222 NECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIK 281

Query: 721 EVESQLGSDDCGKDLNSVTNLQKKH 795
           E E  L S+D GKDL +   L   H
Sbjct: 282 EKEPVLTSEDYGKDLVASEGLFHSH 306


 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 42/178 (23%), Positives = 79/178 (44%)
 Frame = +1

Query: 262  DVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDENYK 441
            ++ ++++ +  +  +L ++A+ R+  L   +N  L   +A ++  WI EK    +     
Sbjct: 1052 NITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELD 1111

Query: 442  EPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLWKD 621
            +   LQ K  + Q    ++  NE R+ D+      LL       +  Q R +EL+  W  
Sbjct: 1112 DVWELQKKFDEFQK---DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELNARWGS 1167

Query: 622  LVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKH 795
            L   +  +   L  A   + F R  +D +  + +    L + D G DL SV  LQ++H
Sbjct: 1168 LQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRH 1225


 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 53/262 (20%), Positives = 104/262 (39%), Gaps = 6/262 (2%)
 Frame = +1

Query: 25   EQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKT 204
            E N+  Q +  D  +AE WI ++E  ++N + G   ++  AL++KHE F   L +  +  
Sbjct: 896  EANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSM 955

Query: 205  QRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFD---- 372
            + L + AN                        A  +++A   +G   +     L+D    
Sbjct: 956  KALRNQAN------------------------ACQQQQAAPVEGVAGEQRVMALYDFQAR 991

Query: 373  --RDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
              R+    K  ++  L + + + +K       +   HQ  +  +       D+     Q 
Sbjct: 992  SpreVTMKKGDVLTLLSSINKDWWK------VEAADHQGIVPAVYVRRLAHDEFPMLPQR 1045

Query: 547  LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
              +   N    I QR E+++  ++ L+  ++ +   L Q   +        DM  W+ E 
Sbjct: 1046 RREEPGN----ITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK 1101

Query: 727  ESQLGSDDCGKDLNSVTNLQKK 792
            +    +++ G +L+ V  LQKK
Sbjct: 1102 K----AENTGVELDDVWELQKK 1119


 Score = 39.7 bits (91), Expect = 0.010
 Identities = 56/236 (23%), Positives = 99/236 (41%), Gaps = 18/236 (7%)
 Frame = +1

Query: 10   RRFLYEQNMDLQ----LFYRDTEQAEA---WIAKQEAFLENNDVGDSLDSVEALIRKHED 168
            R+ L E+ + LQ    LF     +A A   W  K E  L       SL+ +  L + HED
Sbjct: 2027 RQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHED 2086

Query: 169  FEKSLAAQEEKTQRLDDIANKL----VENGHYAAADVN------KKRDDLLIRKANLEEK 318
            F  SLA  +   + L ++  ++    V +  Y    V       K   D++  +    +K
Sbjct: 2087 FLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQK 2146

Query: 319  AKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDEN-YKEPTNLQSKVQKHQNFLAE 495
             + R+  +++    Q F+++A     WI+E      D +  KE   L+S+++ ++    E
Sbjct: 2147 EEARQ--VKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKE 2204

Query: 496  IAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQ 663
            I A + ++  +   G +L D+      DI+     L + W  L       + NL Q
Sbjct: 2205 IQAMKRQLTKIVDLGDNLEDA---LILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQ 2257

>sp|P08032|SPTA1_MOUSE Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin)
          Length = 2415

 Score =  237 bits (605), Expect = 2e-62
 Identities = 117/265 (44%), Positives = 178/265 (67%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W++ +  Y Q +D  LFYRD+EQ ++W+++QEAFLEN D+G+S+ SVEAL++KH+DFE++
Sbjct: 463  WDKCQHQYRQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSVGSVEALLQKHDDFEEA 522

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
              AQEEK   LD+ A KL++N HY + ++   RD LL R+  L E+A  R+  L DS   
Sbjct: 523  FTAQEEKIITLDETATKLIDNDHYDSENIAAIRDGLLARRDALRERAATRRKLLVDSQLL 582

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q   +D+D++K WI +K K A D++YK+  NL+S+VQK Q+F  E+A NE  +++++  G
Sbjct: 583  QQLYQDSDDLKTWINKKKKLADDDDYKDVQNLKSRVQKQQDFEEELAVNEIMLNNLEKTG 642

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
            Q +++  H  S+ +  R+ E+  LWK+L+ A+  K T L +A+   QF  N ED++ WL 
Sbjct: 643  QEMIEDGHYASEAVAARLSEVANLWKELLEATAQKGTQLYEANQLLQFENNAEDLKRWLE 702

Query: 721  EVESQLGSDDCGKDLNSVTNLQKKH 795
            EVE Q+ S+D GK L  V NL +KH
Sbjct: 703  EVEWQVTSEDYGKVLADVQNLLRKH 727


 Score =  177 bits (448), Expect = 4e-44
 Identities = 94/267 (35%), Positives = 156/267 (58%), Gaps = 2/267 (0%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W  R+ + +Q ++LQLF    +Q E+W+  +E  L ++D  D LDS++AL++K +D +K+
Sbjct: 1382 WENRKKMLDQCLELQLFRGKCDQVESWMVARENSLRSDD-RDHLDSLQALMKKRDDLDKA 1440

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            + AQE K   L+++A +L++N HYA  ++  +   +L R   L+E+     G L D  + 
Sbjct: 1441 ITAQEGKISDLENVATRLIDNDHYAKEEIAARLQRVLDRWKALKEQLLTELGKLGDYADL 1500

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            + F RD ++++ WI E L  A DE+YK+PTN+Q K  KHQ F  E+     ++D V + G
Sbjct: 1501 KQFYRDLEDLEEWINEMLPIACDESYKDPTNIQRKYLKHQAFENEVNGRAEQVDGVINLG 1560

Query: 541  QSLLDSD--HNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIW 714
             SL++        +++Q++++ L + W  L+  +  K   L +AS QQ+F  ++ D E W
Sbjct: 1561 NSLIERRVCDGDEENMQEQLDMLKENWDYLLERTTDKGQKLNEASRQQRFNTSIRDFEFW 1620

Query: 715  LAEVESQLGSDDCGKDLNSVTNLQKKH 795
            L+E E  L   D  +DL S  NL KKH
Sbjct: 1621 LSEAEGLLAMKDQARDLTSAGNLLKKH 1647


 Score =  124 bits (311), Expect = 3e-28
 Identities = 77/260 (29%), Positives = 136/260 (52%), Gaps = 1/260 (0%)
 Frame = +1

Query: 19   LYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEE 198
            LYE N  LQ F  + E  + W+ + E  + + D G  L  V+ L+RKH   E  + A++ 
Sbjct: 681  LYEANQLLQ-FENNAEDLKRWLEEVEWQVTSEDYGKVLADVQNLLRKHGLLESDVTARQN 739

Query: 199  KTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRD 378
            +   L D+A    E GH  + D+  +++ LL R   L+E   +RK  L D    Q   RD
Sbjct: 740  QMDTLTDMAAHFEEIGHPDSGDIRARQESLLSRFEALKEPLAIRKKKLIDLLKLQQICRD 799

Query: 379  ADEIKAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLD 555
            +++ +AWI E   +A+  +  K+    ++ + +H+  LA+IA++E RI  +  RG  +++
Sbjct: 800  SEDEEAWIQETEPSAASTHLGKDLVAAKNLLNRHEVILADIASHEPRIQVITERGNKMVE 859

Query: 556  SDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQ 735
              H  ++DI  R+E L+K  + L + +  +E +L      QQ++ ++ + E W+ E E  
Sbjct: 860  EGHFAAEDIASRVESLNKNMESLHARAIRRENDLKANVQLQQYLADLHEAEAWIKEKEPI 919

Query: 736  LGSDDCGKDLNSVTNLQKKH 795
            + + + G D  +   L KKH
Sbjct: 920  VDNKNYGADEEAAGALLKKH 939


 Score =  121 bits (303), Expect = 3e-27
 Identities = 69/252 (27%), Positives = 130/252 (51%), Gaps = 1/252 (0%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            Q F       E W+++ E  L   D    L S   L++KH+  E  + A+E+  + L+D+
Sbjct: 1608 QRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLAREDPLKDLNDL 1667

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            A +L+ +G +    + +K + +  R  N++  A      L++++    F +D D+ +AWI
Sbjct: 1668 AQELISSGTFNIDQIEEKMNGVNERFENVQSLAAAHHEKLKETYALFQFFQDLDDEEAWI 1727

Query: 403  VEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDD 579
             EKL   S ++Y ++  ++Q+ ++KH+    E+ A+E  + +V    +SL D      ++
Sbjct: 1728 EEKLLRVSSQDYGRDLQSVQNLLKKHKRLEGELVAHEPAVQNVLDTAESLRDKAAVGKEE 1787

Query: 580  IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGK 759
            IQ+R+ +  + W+ L   +K +  NL ++    QF+ N E+ E WL E  + +   D G 
Sbjct: 1788 IQERLAQFVQHWEKLKELAKTRGVNLEESLEYLQFMENAEEEEAWLGEKCALVSRGDSGD 1847

Query: 760  DLNSVTNLQKKH 795
             L +  +L KKH
Sbjct: 1848 TLAATQSLLKKH 1859


 Score =  117 bits (293), Expect = 4e-26
 Identities = 75/265 (28%), Positives = 129/265 (48%), Gaps = 1/265 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            +RR       DLQ F RD  +A  W+ ++E  L + D G  L S EAL   H+  E++LA
Sbjct: 253  KRRESLSNAADLQRFKRDVNEAIQWMEEKEPQLTSEDYGKDLVSSEALFHNHKRLERNLA 312

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
              ++K + L   A+KL+ +    A  + + + DL+     +   A  R   L+ S+ Y  
Sbjct: 313  VMDDKVKELCAKADKLMISHSADALQIQQMKLDLVSNWERIRALATNRYAKLKASYGYHR 372

Query: 367  FDRDADEIKAWIVEKLKTA-SDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
            F  D DE+  W+ EK     +DE   +  + ++ + +HQ    EI + + R     + GQ
Sbjct: 373  FLSDYDELSGWMKEKTALINADELPTDVASGEALLARHQQHKHEIDSYDDRFQSADATGQ 432

Query: 544  SLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE 723
             LLD +H  S++I++++  L   W  L+      +    Q      F R+ E ++ W++ 
Sbjct: 433  ELLDGNHEASEEIREKMTILANDWAALLELWDKCQHQYRQCLDFHLFYRDSEQVDSWMSR 492

Query: 724  VESQLGSDDCGKDLNSVTNLQKKHN 798
             E+ L ++D G  + SV  L +KH+
Sbjct: 493  QEAFLENEDLGNSVGSVEALLQKHD 517


 Score =  110 bits (276), Expect = 3e-24
 Identities = 70/252 (27%), Positives = 125/252 (49%), Gaps = 2/252 (0%)
 Frame = +1

Query: 49   FYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDIAN 228
            F++D +  EAWI ++   + + D G  L SV+ L++KH+  E  L A E   Q + D A 
Sbjct: 1716 FFQDLDDEEAWIEEKLLRVSSQDYGRDLQSVQNLLKKHKRLEGELVAHEPAVQNVLDTAE 1775

Query: 229  KLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVE 408
             L +       ++ ++    +     L+E AK R  +LE+S  Y  F  +A+E +AW+ E
Sbjct: 1776 SLRDKAAVGKEEIQERLAQFVQHWEKLKELAKTRGVNLEESLEYLQFMENAEEEEAWLGE 1835

Query: 409  KLKTAS-DENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKS-DDI 582
            K    S  ++       QS ++KH+    + A ++ R+ DV ++G+ +L+ +  ++ D I
Sbjct: 1836 KCALVSRGDSGDTLAATQSLLKKHEALENDFAVHKNRVQDVCAQGEDILNKEETQNKDKI 1895

Query: 583  QQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKD 762
              +I+ L++    L  A    ++ L      QQF    + +E W+ E E+ L +   G D
Sbjct: 1896 STKIQVLNEKTASLAKALAAWKSQLDDVHAFQQFNWKADVVESWIGEKEASLKTKSNGAD 1955

Query: 763  LNSVTNLQKKHN 798
            L +   L  KH+
Sbjct: 1956 LTAFLTLLAKHD 1967


 Score =  110 bits (275), Expect = 4e-24
 Identities = 61/250 (24%), Positives = 126/250 (50%)
 Frame = +1

Query: 46   LFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDIA 225
            LF       E WI      + + ++ + L   E L+ +H++    +  ++   Q L+D  
Sbjct: 1291 LFLSKASDLENWIKTIGGVISSPELAEDLTGTEILLERHQEHHDDIKREDPTFQALEDFG 1350

Query: 226  NKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIV 405
             +L+++GH    +++    ++  ++ NLE+  + RK  L+     QLF    D++++W+V
Sbjct: 1351 TELIDSGHRNRREIDNTLQNINSKRDNLEKSWENRKKMLDQCLELQLFRGKCDQVESWMV 1410

Query: 406  EKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQ 585
             +  +   ++     +LQ+ ++K  +    I A EG+I D+++    L+D+DH   ++I 
Sbjct: 1411 ARENSLRSDDRDHLDSLQALMKKRDDLDKAITAQEGKISDLENVATRLIDNDHYAKEEIA 1470

Query: 586  QRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDL 765
             R++ +   WK L      +   L   +  +QF R++ED+E W+ E+   +  D+  KD 
Sbjct: 1471 ARLQRVLDRWKALKEQLLTELGKLGDYADLKQFYRDLEDLEEWINEM-LPIACDESYKD- 1528

Query: 766  NSVTNLQKKH 795
               TN+Q+K+
Sbjct: 1529 --PTNIQRKY 1536


 Score =  100 bits (249), Expect = 5e-21
 Identities = 54/179 (30%), Positives = 101/179 (56%)
 Frame = +1

Query: 256 AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASDEN 435
           A ++  +R ++L +    +++   R   LE+S++YQ+F RDAD+++ WI+EKL+ A D+ 
Sbjct: 20  AEEIQHRRAEVLNQYQRFKDRVAERGQKLEESYHYQVFRRDADDLEKWIMEKLEIAKDKT 79

Query: 436 YKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLW 615
           Y EPTN+Q K QKH++F++E+ A    + +++   ++    DH   +  +  +++L  LW
Sbjct: 80  Y-EPTNIQGKYQKHESFVSEVQAKSRVLPELEEIREARFAEDHFAHEATKTHLKQLRLLW 138

Query: 616 KDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
             L+  ++ K   L +A    Q+ +  ED+  W+ E E+ +   + G D      L KK
Sbjct: 139 DLLLELTQEKSDVLLRALKFYQYSQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKK 197


 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 74/278 (26%), Positives = 130/278 (46%), Gaps = 12/278 (4%)
 Frame = +1

Query: 1    WNERRFLYEQNMDL-------QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRK 159
            WN  + L ++   L       ++F+R+ +  +  I K+   L   D G  L SV+AL R+
Sbjct: 1163 WNSLKRLADEQYQLLSSAHAVEMFHREADDVKEQIDKKCRALNAADPGSDLLSVQALQRQ 1222

Query: 160  HEDFEKSLAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGS 339
            HE FE+ +    EK   L + A +L E+   A  D+ K+R +L      L+     RK S
Sbjct: 1223 HECFERDIIPLGEKVNTLGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDRKES 1282

Query: 340  LEDSHNYQLFDRDADEIKAWIVEKLKT-----ASDENYKEPTNLQSKVQKHQNFLAEIAA 504
            L ++H + LF   A +++ WI    KT     +S E  ++ T  +  +++HQ    +I  
Sbjct: 1283 LNEAHKFFLFLSKASDLENWI----KTIGGVISSPELAEDLTGTEILLERHQEHHDDIKR 1338

Query: 505  NEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQF 684
             +     ++  G  L+DS H    +I   ++ ++    +L  + + ++  L Q    Q F
Sbjct: 1339 EDPTFQALEDFGTELIDSGHRNRREIDNTLQNINSKRDNLEKSWENRKKMLDQCLELQLF 1398

Query: 685  IRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKHN 798
                + +E W+   E+ L SDD    L+S+  L KK +
Sbjct: 1399 RGKCDQVESWMVARENSLRSDD-RDHLDSLQALMKKRD 1435


 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 61/273 (22%), Positives = 134/273 (49%), Gaps = 8/273 (2%)
 Frame = +1

Query: 1   WNERRFLYEQNMDLQL----FYRDTEQAE---AWIAKQEAFLENNDVGDSLDSVEALIRK 159
           W+    L ++  D+ L    FY+ +++ E    W+ ++EA +   ++GD  +  E L +K
Sbjct: 138 WDLLLELTQEKSDVLLRALKFYQYSQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKK 197

Query: 160 HEDFEKSLAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGS 339
            E+F++ L A++ K  R++  AN+  +  H    ++  K+D++      L   A  R+ S
Sbjct: 198 FEEFQEELTARKGKVDRVNQYANECAQEKHPKLPEIKAKQDEVNAAWDRLWSLALKRRES 257

Query: 340 LEDSHNYQLFDRDADEIKAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGR 516
           L ++ + Q F RD +E   W+ EK    + E+Y K+  + ++    H+     +A  + +
Sbjct: 258 LSNAADLQRFKRDVNEAIQWMEEKEPQLTSEDYGKDLVSSEALFHNHKRLERNLAVMDDK 317

Query: 517 IDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNV 696
           + ++ ++   L+ S    +  IQQ   +L   W+ + + +  +   L  + G  +F+ + 
Sbjct: 318 VKELCAKADKLMISHSADALQIQQMKLDLVSNWERIRALATNRYAKLKASYGYHRFLSDY 377

Query: 697 EDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKH 795
           +++  W+ E  + + +D+   D+ S   L  +H
Sbjct: 378 DELSGWMKEKTALINADELPTDVASGEALLARH 410


 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 67/273 (24%), Positives = 124/273 (45%), Gaps = 16/273 (5%)
 Frame = +1

Query: 25   EQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKT 204
            E++++   F  + E+ EAW+ ++ A +   D GD+L + ++L++KHE  E   A  + + 
Sbjct: 1814 EESLEYLQFMENAEEEEAWLGEKCALVSRGDSGDTLAATQSLLKKHEALENDFAVHKNRV 1873

Query: 205  QRL----DDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFD 372
            Q +    +DI NK           ++ K   L  + A+L +     K  L+D H +Q F+
Sbjct: 1874 QDVCAQGEDILNKEETQN---KDKISTKIQVLNEKTASLAKALAAWKSQLDDVHAFQQFN 1930

Query: 373  RDADEIKAWIVEK---LKTASDENYKEPTNLQSKVQKHQNFLAEIAA-NEGRIDDVKSRG 540
              AD +++WI EK   LKT S  N  + T   + + KH    A + +  + R+ ++    
Sbjct: 1931 WKADVVESWIGEKEASLKTKS--NGADLTAFLTLLAKHDTLDASLQSFQQERLSEIAELK 1988

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQ--------FIRNV 696
              L+  +H+++  I+++   L + W+ L+ AS++    L +     Q        F    
Sbjct: 1989 DQLVAGEHSQAKAIEEQHAALLRHWEQLLEASRVHRQKLLEKQLPLQKAEELFMEFAHKA 2048

Query: 697  EDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKH 795
                 W    E  +        LN +  LQK+H
Sbjct: 2049 SAFNNWCENAEEDMSEPVHCVSLNEIRQLQKEH 2081


 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 66/268 (24%), Positives = 118/268 (44%), Gaps = 5/268 (1%)
 Frame = +1

Query: 7   ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
           ER    E++   Q+F RD +  E WI ++    ++     +  +++   +KHE F   + 
Sbjct: 43  ERGQKLEESYHYQVFRRDADDLEKWIMEKLEIAKDKTYEPT--NIQGKYQKHESFVSEVQ 100

Query: 187 AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
           A+      L++I        H+A          L +    L E  + +   L  +  +  
Sbjct: 101 AKSRVLPELEEIREARFAEDHFAHEATKTHLKQLRLLWDLLLELTQEKSDVLLRALKFYQ 160

Query: 367 FDRDADEIKAWIVEK-----LKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVK 531
           + ++ ++I  W+ EK     L    D+   E T +  K  K + F  E+ A +G++D V 
Sbjct: 161 YSQECEDILEWVKEKEAIVTLVELGDD--WERTEVLHK--KFEEFQEELTARKGKVDRVN 216

Query: 532 SRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEI 711
                     H K  +I+ + +E++  W  L S +  +  +L+ A+  Q+F R+V +   
Sbjct: 217 QYANECAQEKHPKLPEIKAKQDEVNAAWDRLWSLALKRRESLSNAADLQRFKRDVNEAIQ 276

Query: 712 WLAEVESQLGSDDCGKDLNSVTNLQKKH 795
           W+ E E QL S+D GKDL S   L   H
Sbjct: 277 WMEEKEPQLTSEDYGKDLVSSEALFHNH 304


 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 49/171 (28%), Positives = 88/171 (51%), Gaps = 1/171 (0%)
 Frame = +1

Query: 34   MDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRL 213
            + LQ   RD+E  EAWI + E    +  +G  L + + L+ +HE     +A+ E + Q +
Sbjct: 791  LKLQQICRDSEDEEAWIQETEPSAASTHLGKDLVAAKNLLNRHEVILADIASHEPRIQVI 850

Query: 214  DDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIK 393
             +  NK+VE GH+AA D+  + + L     +L  +A  R+  L+ +   Q +  D  E +
Sbjct: 851  TERGNKMVEEGHFAAEDIASRVESLNKNMESLHARAIRRENDLKANVQLQQYLADLHEAE 910

Query: 394  AWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
            AWI EK     ++NY  +     + ++KH+ FL ++ A E  I  ++ + +
Sbjct: 911  AWIKEKEPIVDNKNYGADEEAAGALLKKHEAFLVDLNAFENSIKALRDQAE 961


 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 51/249 (20%), Positives = 119/249 (47%), Gaps = 1/249 (0%)
 Frame = +1

Query: 49   FYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDIAN 228
            F  D ++   W+ ++ A +  +++   + S EAL+ +H+  +  + + +++ Q  D    
Sbjct: 373  FLSDYDELSGWMKEKTALINADELPTDVASGEALLARHQQHKHEIDSYDDRFQSADATGQ 432

Query: 229  KLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVE 408
            +L++  H A+ ++ +K   L    A L E     +       ++ LF RD++++ +W+  
Sbjct: 433  ELLDGNHEASEEIREKMTILANDWAALLELWDKCQHQYRQCLDFHLFYRDSEQVDSWMSR 492

Query: 409  KLKTASDENYKEPT-NLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQ 585
            +     +E+      ++++ +QKH +F     A E +I  +      L+D+DH  S++I 
Sbjct: 493  QEAFLENEDLGNSVGSVEALLQKHDDFEEAFTAQEEKIITLDETATKLIDNDHYDSENIA 552

Query: 586  QRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDL 765
               + L      L   +  +   L  +   QQ  ++ +D++ W+ + + +L  DD  KD+
Sbjct: 553  AIRDGLLARRDALRERAATRRKLLVDSQLLQQLYQDSDDLKTWINK-KKKLADDDDYKDV 611

Query: 766  NSVTNLQKK 792
             ++ +  +K
Sbjct: 612  QNLKSRVQK 620


 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 64/281 (22%), Positives = 126/281 (44%), Gaps = 19/281 (6%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR L ++  +  L Y   +  E WI  QE   EN  V   LD V  L +K ++F++ L +
Sbjct: 1073 RRRLLQRYNEFLLAYEAGDMLE-WI--QEKKTENTGV--ELDDVWELQKKFDEFQRDLKS 1127

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRK------------ 333
             E + +                  D+NK  D+LL  +    E A +R+            
Sbjct: 1128 NEPRLK------------------DINKVADELLFEELLTPEGAHIRQELNTRWNSLKRL 1169

Query: 334  -----GSLEDSHNYQLFDRDADEIKAWIVEKLK--TASDENYKEPTNLQSKVQKHQNFLA 492
                   L  +H  ++F R+AD++K  I +K +   A+D    +  ++Q+  ++H+ F  
Sbjct: 1170 ADEQYQLLSSAHAVEMFHREADDVKEQIDKKCRALNAADPG-SDLLSVQALQRQHECFER 1228

Query: 493  EIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASG 672
            +I     +++ +    + L +S  + ++D+Q++  EL++ W  L   +  ++ +L +A  
Sbjct: 1229 DIIPLGEKVNTLGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDRKESLNEAHK 1288

Query: 673  QQQFIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKH 795
               F+    D+E W+  +   + S +  +DL     L ++H
Sbjct: 1289 FFLFLSKASDLENWIKTIGGVISSPELAEDLTGTEILLERH 1329


 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 57/254 (22%), Positives = 107/254 (42%)
 Frame = +1

Query: 31   NMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQR 210
            N+ LQ +  D  +AEAWI ++E  ++N + G   ++  AL++KHE F   L A E   + 
Sbjct: 896  NVQLQQYLADLHEAEAWIKEKEPIVDNKNYGADEEAAGALLKKHEAFLVDLNAFENSIKA 955

Query: 211  LDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEI 390
            L D A   V     AA      R+  +I   + E +++                R+    
Sbjct: 956  LRDQAE--VCQQQQAAPVDEAGREARVIALYDFEARSR----------------REVSMK 997

Query: 391  KAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNK 570
            K  ++  L + + + +K       +   HQ F+  +   +   D++    Q   +   N 
Sbjct: 998  KNDVLTLLSSINKDWWK------VEADDHQGFVPAVYVRKLAPDELPGFPQHQREEPVN- 1050

Query: 571  SDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDD 750
               I Q  ++++ L+  L+  ++ +   L Q   +        DM  W+ E +    +++
Sbjct: 1051 ---IPQLQQQVETLYHSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----TEN 1103

Query: 751  CGKDLNSVTNLQKK 792
             G +L+ V  LQKK
Sbjct: 1104 TGVELDDVWELQKK 1117


 Score = 36.2 bits (82), Expect = 0.11
 Identities = 54/235 (22%), Positives = 98/235 (41%), Gaps = 17/235 (7%)
 Frame = +1

Query: 10   RRFLYEQNMDLQ----LFYRDTEQAEA---WIAKQEAFLENNDVGDSLDSVEALIRKHED 168
            R+ L E+ + LQ    LF     +A A   W    E  +       SL+ +  L ++HE 
Sbjct: 2024 RQKLLEKQLPLQKAEELFMEFAHKASAFNNWCENAEEDMSEPVHCVSLNEIRQLQKEHEA 2083

Query: 169  FEKSLAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKAN------LEEKAKLR 330
            F  SLA  +E    L ++ +K ++  +  ++       D+L R  N       E + +L+
Sbjct: 2084 FLASLAGAQEDFNYLLEL-DKQIKALNVPSSPYTWLTVDVLGRIWNHLPDIIKEREQELQ 2142

Query: 331  KGSLEDSHNYQL---FDRDADEIKAWIVEKLKTASDEN-YKEPTNLQSKVQKHQNFLAEI 498
            K       N+++   F+++A     WI E      D +  KE   L+S+++ ++    EI
Sbjct: 2143 KEEARQIKNFEMCQEFEQNASAFLQWIQETRAYFLDGSLLKETGTLESQLEANKRKQKEI 2202

Query: 499  AANEGRIDDVKSRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQ 663
             A +  +  ++  G S+   +     DI+     L + W  L       + NL Q
Sbjct: 2203 QAMKRHLTKIEDLGDSM---EEALILDIKYSTIGLAQQWDQLHQLGMRMQHNLEQ 2254

>sp|Q01082|SPTB2_HUMAN Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1)
            (Beta-II spectrin) (Fodrin beta chain)
          Length = 2364

 Score =  164 bits (414), Expect = 3e-40
 Identities = 92/264 (34%), Positives = 146/264 (55%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W  R+ L  Q+   Q F RDT+QAEA++  QE  L + ++  +L+  EA I+K EDF  +
Sbjct: 1158 WENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTT 1217

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            + A EEK   + +   +LV +G+  +  + +K D +  R     E A      L+D+ + 
Sbjct: 1218 MDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL 1277

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q F +D  E+  WI EK+ TA D +Y E  NL SK  KHQ F+AE+A+N+  +D ++  G
Sbjct: 1278 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEG 1337

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
              L+         +++++  L K+W+ L S ++ K   L  A+  + F ++  D++ WL 
Sbjct: 1338 MQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH 1397

Query: 721  EVESQLGSDDCGKDLNSVTNLQKK 792
             +ESQ+ SDD GK L SV  L KK
Sbjct: 1398 GLESQIQSDDYGKHLTSVNILLKK 1421


 Score =  112 bits (279), Expect = 2e-24
 Identities = 73/267 (27%), Positives = 130/267 (48%), Gaps = 5/267 (1%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR   E N+ LQ  +++      W+ + +  + + D G  L  VE L++KH   E  +  
Sbjct: 520  RRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGI 579

Query: 190  QEEKTQRLDDIANKLVENGH-YAAADVNKKRDDLLIRKANLEEKAKL---RKGSLEDSHN 357
            Q E+ + ++  A K   +G  Y   D    RD +   +   +E  +L   R+  LE+S  
Sbjct: 580  QAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRR 639

Query: 358  YQLFDRDADEIKAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKS 534
               F  +  E + WI EK K  S ++Y K+ T++   + KH+ F  E++   G  +    
Sbjct: 640  LWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIK 699

Query: 535  RGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIW 714
             G+ ++  +H  S+ I++RI  + + W +L   S I++  L +AS   QF  + +D++ W
Sbjct: 700  EGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAW 759

Query: 715  LAEVESQLGSDDCGKDLNSVTNLQKKH 795
            + ++   + S D G D  S  +L KKH
Sbjct: 760  MLDILKIVSSSDVGHDEYSTQSLVKKH 786


 Score =  111 bits (277), Expect = 3e-24
 Identities = 58/264 (21%), Positives = 132/264 (50%), Gaps = 2/264 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            R+   +  + L   + + +  E WI ++E +L N  + + L+ +E +  + E  E  +  
Sbjct: 841  RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNN 900

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
            Q  +   ++ IA +L+ +GH +  ++  ++D L  R +   E    +K +L  + + Q +
Sbjct: 901  QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNY 960

Query: 370  DRDADEIKAWIVEKLKT--ASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
              + +E K+WI EK K   ++ +   +   + +  +K      ++ A E ++ D++   +
Sbjct: 961  HLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAE 1020

Query: 544  SLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE 723
             L     +++  I  R+ E+  +W+++ +  K +E +L +AS  QQF+R+++D + WL+ 
Sbjct: 1021 KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSR 1080

Query: 724  VESQLGSDDCGKDLNSVTNLQKKH 795
             ++ + S+D    L     L  +H
Sbjct: 1081 TQTAIASEDMPNTLTEAEKLLTQH 1104


 Score =  110 bits (274), Expect = 6e-24
 Identities = 69/254 (27%), Positives = 133/254 (52%), Gaps = 3/254 (1%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            +LF +     + W+   E+ ++++D G  L SV  L++K +  E  +  ++++ + L   
Sbjct: 1383 ELFTQSCADLDKWLHGLESQIQSDDYGKHLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1442

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            A  L + G  +  +V+ KR  +  +   L E    RK +L  S     F+RD ++   W+
Sbjct: 1443 AQALSQEGK-STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1501

Query: 403  VEK--LKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLL-DSDHNKS 573
             E+  L T++D  +   T +Q  ++K+Q    EI  ++ RIDD+  R Q+++ DS    +
Sbjct: 1502 GERMPLATSTDHGHNLQT-VQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1560

Query: 574  DDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDC 753
            + I+QR+ +L +LW  L+  ++ +   L +A   QQ+  +  + E W++E E  + S++ 
Sbjct: 1561 EAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEK 1620

Query: 754  GKDLNSVTNLQKKH 795
             KD  S  ++ KKH
Sbjct: 1621 AKDEQSAVSMLKKH 1634


 Score =  108 bits (270), Expect = 2e-23
 Identities = 64/263 (24%), Positives = 131/263 (49%), Gaps = 1/263 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ERR   E++  L  F+ +  + E WI ++E  L ++D G  L SV  L+ KH  FE  ++
Sbjct: 629  ERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMS 688

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
             +    ++       ++   H+ +  + ++   +  + ANLE+ + +RK  LE++     
Sbjct: 689  GRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQ 748

Query: 367  FDRDADEIKAWIVEKLKTASDENY-KEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
            F  DAD+I AW+++ LK  S  +   +  + QS V+KH++   EIA     +D +  +  
Sbjct: 749  FQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQA- 807

Query: 544  SLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE 723
            S L  +H +S D++ R+  +++ +K++   +++++  L       +     +  E+W+ E
Sbjct: 808  SALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDE 867

Query: 724  VESQLGSDDCGKDLNSVTNLQKK 792
             E  L +    + L  +  +Q +
Sbjct: 868  KEQWLNNMQIPEKLEDLEVIQHR 890


 Score =  107 bits (268), Expect = 3e-23
 Identities = 72/268 (26%), Positives = 132/268 (49%), Gaps = 5/268 (1%)
 Frame = +1

Query: 4    NERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSL 183
            NER+     + ++  F RD E    W+ ++     + D G +L +V+ LI+K++  +K +
Sbjct: 1475 NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEI 1534

Query: 184  AAQEEKTQRLDDI----ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDS 351
               +    R+DDI     N + ++   +A  + ++  DL      L E+ + R   LE++
Sbjct: 1535 QGHQ---PRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA 1591

Query: 352  HNYQLFDRDADEIKAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDV 528
            H  Q +  DA E +AW+ E +L   S+E  K+  +  S ++KHQ     +      +  +
Sbjct: 1592 HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQL 1651

Query: 529  KSRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDME 708
                ++L+   H +S+ I  R  ++DKL+  L   ++ +   L +     Q  R V+D+E
Sbjct: 1652 SKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLE 1711

Query: 709  IWLAEVESQLGSDDCGKDLNSVTNLQKK 792
             W+AE E   GS + G+D   VT LQ++
Sbjct: 1712 QWIAEREVVAGSHELGQDYEHVTMLQER 1739


 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 68/267 (25%), Positives = 130/267 (48%), Gaps = 4/267 (1%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ERR   ++   L    R+ +  E WIA++E    ++++G   + V  L  +  +F +   
Sbjct: 1689 ERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTG 1748

Query: 187  -AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQ 363
               +E+   ++ +A++L+ +GH  AA + + +D L    A+L E    R   L  S+   
Sbjct: 1749 NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELH 1808

Query: 364  LFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVK---S 534
             F  DA EI   I +K K   +E  ++   +++  + H  F  +I A   ++  ++   +
Sbjct: 1809 KFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAA 1868

Query: 535  RGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIW 714
            R Q+    D  K+DDIQ+R  E+ + WK L+ A + +   L     + +F   V D+ +W
Sbjct: 1869 RLQAAYAGD--KADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLW 1926

Query: 715  LAEVESQLGSDDCGKDLNSVTNLQKKH 795
            + +V  Q+ + +  +D++SV  L   H
Sbjct: 1927 MEDVIRQIEAQEKPRDVSSVELLMNNH 1953


 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 57/255 (22%), Positives = 127/255 (49%), Gaps = 4/255 (1%)
 Frame = +1

Query: 43   QLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDI 222
            Q +Y D  +AEAW+++QE ++ + +      S  ++++KH+  E+++    E   +L   
Sbjct: 1595 QQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKT 1654

Query: 223  ANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWI 402
            +  LV + H  +  ++ ++  +    A L++ A+ R+G L++ H     +R+ D+++ WI
Sbjct: 1655 SRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWI 1714

Query: 403  VEKLKTASD----ENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNK 570
             E+   A      ++Y+  T LQ + ++       I   + R+D V      L++S H+ 
Sbjct: 1715 AEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI--GQERVDTVNHLADELINSGHSD 1772

Query: 571  SDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDD 750
            +  I +  + L++ W DL+     +   L  +    +F  + +++   + +   +L  ++
Sbjct: 1773 AATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEE 1831

Query: 751  CGKDLNSVTNLQKKH 795
             G+D N+V  LQ+ H
Sbjct: 1832 LGRDQNTVETLQRMH 1846


 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 66/254 (25%), Positives = 118/254 (46%), Gaps = 5/254 (1%)
 Frame = +1

Query: 49   FYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDIAN 228
            F R     E W+++ +  +  ++ G  L +VEA  +KHE  E  +AA EE+ Q +  +A 
Sbjct: 427  FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR 486

Query: 229  KLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVE 408
            +L    ++    +  ++D+++     L E  + R+  LE +   Q   ++   I  W+ E
Sbjct: 487  ELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDE 546

Query: 409  -KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSL-LDSDHNKSDD- 579
             K+   S +  K    ++  +QKH    A+I     R+  V +  Q    D +  K  D 
Sbjct: 547  MKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDP 606

Query: 580  --IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDC 753
              I+ R+  ++  +++L   +  +   L ++    +F   + + E W+ E E  L SDD 
Sbjct: 607  QVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDY 666

Query: 754  GKDLNSVTNLQKKH 795
            GKDL SV  L  KH
Sbjct: 667  GKDLTSVMRLLSKH 680


 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 61/251 (24%), Positives = 133/251 (52%), Gaps = 7/251 (2%)
 Frame = +1

Query: 40   LQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDD 219
            LQ F RD +  ++W+++ +  + + D+ ++L   E L+ +HE+ +  +   EE  Q++ D
Sbjct: 1064 LQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRD 1123

Query: 220  IANKLVENGHYAAADVNKKRDDLLIRKAN-LEEKAKLRKGSLEDSHNYQLFDRDADEIKA 396
            +   + +    A     ++R   L    N L +  + R+  L  SH YQ F RD  + +A
Sbjct: 1124 MGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA 1183

Query: 397  WIVEKLKTASDENYKEPTNL---QSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHN 567
            ++  +    +  + + PT L   ++ ++K ++F+  + ANE +I+ V   G+ L+   + 
Sbjct: 1184 FLNNQEYVLA--HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNI 1241

Query: 568  KSDDIQQRIEEL-DKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE--VESQL 738
             SD IQ++++ + D+  K+  +AS++    L      Q+F+++ +++ +W+ E  + +Q 
Sbjct: 1242 NSDRIQEKVDSIDDRHRKNRETASELL-MRLKDNRDLQKFLQDCQELSLWINEKMLTAQD 1300

Query: 739  GSDDCGKDLNS 771
             S D  ++L+S
Sbjct: 1301 MSYDEARNLHS 1311


 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 64/274 (23%), Positives = 122/274 (44%), Gaps = 10/274 (3%)
 Frame = +1

Query: 1    WNERRFLYEQNMD-------LQLFYRDTEQAEAWIAKQEAFLENN-DVGDSLDSVEALIR 156
            W++ R L ++  D       +Q ++ +  + ++WI ++   +E+  D+G+ L  V AL R
Sbjct: 937  WSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQR 996

Query: 157  KHEDFEKSLAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKG 336
            K    E+ L A E K   L   A KL       A  +  +  ++      ++   K R+ 
Sbjct: 997  KLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREA 1056

Query: 337  SLEDSHNYQLFDRDADEIKAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEG 513
            SL ++   Q F RD D+ ++W+   +   AS++     T  +  + +H+N   EI   E 
Sbjct: 1057 SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEE 1116

Query: 514  RIDDVKSRGQSLLDSDHNKSDD-IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIR 690
                ++  G+ +     +     ++QR++ LD  W +L    + ++  L+Q+   QQF+R
Sbjct: 1117 DYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLR 1176

Query: 691  NVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKK 792
            + +  E +L   E  L   +    L       KK
Sbjct: 1177 DTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKK 1210


 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 61/257 (23%), Positives = 120/257 (46%), Gaps = 4/257 (1%)
 Frame = +1

Query: 37   DLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLD 216
            +L  FY D ++    I  +   L   ++G   ++VE L R H  FE  + A   + ++L 
Sbjct: 1806 ELHKFYHDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQ 1864

Query: 217  DIANKLVENGHYA---AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADE 387
            + A +L     YA   A D+ K+ +++L    +L +  + R+  L D+ +   F     +
Sbjct: 1865 EDAARL--QAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRD 1922

Query: 388  IKAWIVEKLKTA-SDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDH 564
            +  W+ + ++   + E  ++ ++++  +  HQ   AEI A           G+SLL   H
Sbjct: 1923 LMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKH 1982

Query: 565  NKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGS 744
              S++I++++ +L +  K+++   + +   L       QF R+    E WL   E  L S
Sbjct: 1983 YASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSS 2042

Query: 745  DDCGKDLNSVTNLQKKH 795
             + G+ ++ V  L K+H
Sbjct: 2043 REIGQSVDEVEKLIKRH 2059


 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 32/94 (34%), Positives = 52/94 (55%), Gaps = 1/94 (1%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W +R       +++  F RD   AEAW+  QE +L + ++G S+D VE LI++HE FEKS
Sbjct: 2006 WEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKS 2065

Query: 181  LAAQEEKTQRLDDIAN-KLVENGHYAAADVNKKR 279
             A  +E+   L+ +   +L+E       +  K+R
Sbjct: 2066 AATWDERFSALERLTTLELLEVRRQQEEEERKRR 2099


 Score = 32.7 bits (73), Expect = 1.2
 Identities = 22/76 (28%), Positives = 34/76 (44%), Gaps = 8/76 (10%)
 Frame = +1

Query: 592 IEELDKLWKDLVSASKIKETNLTQASGQQQ--------FIRNVEDMEIWLAEVESQLGSD 747
           I +++K W+ L  A   +E  L     +Q+        F R     E WL+E +  +  D
Sbjct: 389 ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD 448

Query: 748 DCGKDLNSVTNLQKKH 795
           + G DL +V    KKH
Sbjct: 449 NFGFDLPAVEAATKKH 464

>sp|Q9QWN8|SPTN2_RAT Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2)
            (Beta-III spectrin) (SPNB-3) (Beta SpIII sigma 1)
            (Spectrin-like protein GTRAP41)
          Length = 2388

 Score =  161 bits (408), Expect = 2e-39
 Identities = 91/264 (34%), Positives = 143/264 (54%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W  R+    Q    Q F RD  QAE  ++ QE FL + ++  +L + +A I+K EDF  +
Sbjct: 1161 WESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYFLSHTEMPGTLQAADAAIKKLEDFMST 1220

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            + A  E+ + L +   +LV  G+  A  + +K D +  R    +E  +   G L D+   
Sbjct: 1221 MDANGERIRGLLEAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQEAVQQLLGRLRDNREQ 1280

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q F +D  E+K WI EK+ TA D +Y E  NL +K QKHQ F+AE+AAN+  +D V   G
Sbjct: 1281 QHFLQDCQELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEG 1340

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
            + L          + +++E+L + W +L + ++ K  +L  A+  + F ++   +E WL 
Sbjct: 1341 RELTLEKPELKVLVSEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLE 1400

Query: 721  EVESQLGSDDCGKDLNSVTNLQKK 792
             +++QL SDD GKDL SV  L KK
Sbjct: 1401 SLQAQLHSDDYGKDLTSVNILLKK 1424


 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 71/262 (27%), Positives = 126/262 (48%), Gaps = 1/262 (0%)
 Frame = +1

Query: 13   RFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQ 192
            R L++ N   +LF +     E+W+   +A L ++D G  L SV  L++K +  E+ +A +
Sbjct: 1377 RSLFDANR-AELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVR 1435

Query: 193  EEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFD 372
            E++ + +   A  L +    +A +V +    +  +   L +  K R   L+ S     F 
Sbjct: 1436 EKEVEAIQAQAKALAQEDQ-SAGEVERTSRAVEEKFRALCQPMKDRCRRLQASREQHQFH 1494

Query: 373  RDADEIKAWIVEKLKTASD-ENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSL 549
            RD ++   W+ E+L  AS  E+ K+  ++Q  ++K+Q    EI  +E RI D+K R ++L
Sbjct: 1495 RDVEDEILWVTERLPMASSLEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLKERQRTL 1554

Query: 550  LDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVE 729
                   +      + EL ++WK L    +++   L +A   QQF R+  + E W+ E E
Sbjct: 1555 ------GTAAAGPELAELQEMWKRLSHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQE 1608

Query: 730  SQLGSDDCGKDLNSVTNLQKKH 795
              +   +  KD  S     KKH
Sbjct: 1609 LHMMGQEKAKDELSAQAEVKKH 1630


 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 68/260 (26%), Positives = 119/260 (45%), Gaps = 5/260 (1%)
 Frame = +1

Query: 31   NMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQR 210
            N++LQ  ++D      W+A+ +  L++ D+G  L  VE L++ HE  E  +A Q E+ + 
Sbjct: 530  NLELQKVFQDLLYLMDWMAEMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRA 589

Query: 211  LDDIANKLVENG-HYAAADVNKKRDDLLIRKANLE---EKAKLRKGSLEDSHNYQLFDRD 378
            +   A +  + G  Y   D     + +   + + E   E A  R+  LE+S     F  +
Sbjct: 590  VSASALRFCDPGKEYRPCDPQLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWE 649

Query: 379  ADEIKAWIVEKLKT-ASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLD 555
              E +AW+ E+    AS E  ++ T +   + KH     E++   G +     +GQ L+ 
Sbjct: 650  VGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVA 709

Query: 556  SDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQ 735
              H  ++    R  EL   W+ L + ++ +   L QA+   QF  +  DME WL +    
Sbjct: 710  EGHPGANQASTRAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRL 769

Query: 736  LGSDDCGKDLNSVTNLQKKH 795
            + S + G D  S   L ++H
Sbjct: 770  VSSPEVGHDEFSTQALARQH 789


 Score = 93.2 bits (230), Expect = 7e-19
 Identities = 67/249 (26%), Positives = 119/249 (47%), Gaps = 1/249 (0%)
 Frame = +1

Query: 49   FYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDIAN 228
            F+RD E    W+ ++     + + G  L SV+ L++K++  +K +   E    R+ D+  
Sbjct: 1493 FHRDVEDEILWVTERLPMASSLEHGKDLPSVQLLMKKNQTLQKEIQGHEP---RIADLKE 1549

Query: 229  KLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVE 408
            +    G  AA     +  ++  R   L  + +LR   LE++   Q F RDA E +AW+ E
Sbjct: 1550 RQRTLGTAAAGPELAELQEMWKR---LSHELELRGKRLEEALRAQQFYRDAAEAEAWMGE 1606

Query: 409  K-LKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQ 585
            + L     E  K+  + Q++V+KHQ     +A     I  + +  Q ++D +H +S  + 
Sbjct: 1607 QELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIKQLAASSQDMIDHEHPESTRLT 1666

Query: 586  QRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDCGKDL 765
             R  ++DKL+  L   +  +   L +     Q  R ++D+E W+ E E    S + G+D 
Sbjct: 1667 IRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDY 1726

Query: 766  NSVTNLQKK 792
              VT L+ K
Sbjct: 1727 EHVTMLRDK 1735


 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 65/257 (25%), Positives = 127/257 (49%), Gaps = 2/257 (0%)
 Frame = +1

Query: 31   NMDLQLFYRDTEQAEAWIAKQEAFLENNDVG-DSLDSVEALIRKHEDFEKSLAAQEEKTQ 207
            N + Q F +D ++ + WI   E  L   DV  D   ++    +KH+ F   LAA ++   
Sbjct: 1277 NREQQHFLQDCQELKLWI--DEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLD 1334

Query: 208  RLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADE 387
            ++D    +L          V++K +DL  R   LE   + +  SL D++  +LF +    
Sbjct: 1335 KVDKEGRELTLEKPELKVLVSEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSA 1394

Query: 388  IKAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDH 564
            +++W+   + +  SD+  K+ T++   ++K Q    E+A  E  ++ ++++ ++L   D 
Sbjct: 1395 LESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQ 1454

Query: 565  NKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGS 744
            + + ++++    +++ ++ L    K +   L  +  Q QF R+VED  +W+ E      S
Sbjct: 1455 S-AGEVERTSRAVEEKFRALCQPMKDRCRRLQASREQHQFHRDVEDEILWVTERLPMASS 1513

Query: 745  DDCGKDLNSVTNLQKKH 795
             + GKDL SV  L KK+
Sbjct: 1514 LEHGKDLPSVQLLMKKN 1530


 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 60/261 (22%), Positives = 122/261 (46%), Gaps = 4/261 (1%)
 Frame = +1

Query: 25   EQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKT 204
            E+ +  Q FYRD  +AEAW+ +QE  +   +      S +A ++KH+  E++LA   +  
Sbjct: 1585 EEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTI 1644

Query: 205  QRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDAD 384
            ++L   +  ++++ H  +  +  ++  +    A L+E A  R+  L++        R+ D
Sbjct: 1645 KQLAASSQDMIDHEHPESTRLTIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELD 1704

Query: 385  EIKAWIVEKLKTASD----ENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLL 552
            +++ WI E+   A+     ++Y+  T L+ K ++     + I   + R+D   +    L+
Sbjct: 1705 DLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTI--GQERVDSANALANGLI 1762

Query: 553  DSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVES 732
               H     + +  + L++ W DL+     +   L  A   Q+F+         +   + 
Sbjct: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQ 1822

Query: 733  QLGSDDCGKDLNSVTNLQKKH 795
            QL  D  G+DLN+   LQ++H
Sbjct: 1823 QL-PDGTGRDLNAAEALQRRH 1842


 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 57/254 (22%), Positives = 113/254 (44%), Gaps = 5/254 (1%)
 Frame = +1

Query: 49   FYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDIAN 228
            F R     E W+++ +  +  ++ G  L +VEA +RKHE  E  + A   + Q +D +A 
Sbjct: 430  FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAA 489

Query: 229  KLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVE 408
            +L    ++    +  +++++      L E    R+  L  +   Q   +D   +  W+ E
Sbjct: 490  ELAAEHYHDIKRIAARQNNVARLWDFLREMVAARRERLLLNLELQKVFQDLLYLMDWMAE 549

Query: 409  -KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLD--SDHNKSDD 579
             K +  S +  K    ++  +Q H+   A+IA    R+  V +      D   ++   D 
Sbjct: 550  MKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYRPCDP 609

Query: 580  --IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDC 753
              + +R+  L++ ++ L   +  +   L ++    +F+  V + E W+ E +  L S + 
Sbjct: 610  QLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAET 669

Query: 754  GKDLNSVTNLQKKH 795
            G+DL  V  L  KH
Sbjct: 670  GRDLTGVLRLLNKH 683


 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 54/257 (21%), Positives = 121/257 (47%), Gaps = 2/257 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ERR   ++++ L    R+ +  E WI ++E    ++++G   + V  L  K  +F +  +
Sbjct: 1685 ERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTS 1744

Query: 187  A-QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQ 363
               +E+    + +AN L+  GH A A V + +D L    A+L E    R   L  ++  Q
Sbjct: 1745 TIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQ 1804

Query: 364  LFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
             F   A +  A +  K +   D   ++    ++  ++H  +  +I A   ++  V+  G 
Sbjct: 1805 RFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSTQVQQVQDDGL 1864

Query: 544  SLLDS-DHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
             L  +   +K+++I + ++ + + W  L  +S  +   L   + + +F + V ++ +W+ 
Sbjct: 1865 RLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMD 1924

Query: 721  EVESQLGSDDCGKDLNS 771
             +  Q+ + +  +D++S
Sbjct: 1925 GINLQMDAQERPRDVSS 1941


 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 54/244 (22%), Positives = 114/244 (46%), Gaps = 1/244 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR   E++  L  F  +  +AEAW+ +Q+  L + + G  L  V  L+ KH      ++ 
Sbjct: 633  RRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSG 692

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
            +    +   +   +LV  GH  A   + +  +L  +   LE  A+ R   L  + +   F
Sbjct: 693  RLGPLKLTLEQGQQLVAEGHPGANQASTRAAELQAQWERLEALAEERAQRLAQAASLYQF 752

Query: 370  DRDADEIKAWIVEKLK-TASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
              DA++++AW+V+ L+  +S E   +  + Q+  ++H+    EI A+   +D ++ +  +
Sbjct: 753  QADANDMEAWLVDALRLVSSPEVGHDEFSTQALARQHRALEEEIRAHRPTLDALREQAAA 812

Query: 547  LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
            L  +  + + ++Q R+  L++ +++L + +  +   L  A      +       +W+ E 
Sbjct: 813  LPPA-LSHTPEVQGRVPTLEQHYEELQARAGERARALEAALAFYTMLSEAGACGLWVEEK 871

Query: 727  ESQL 738
            E  L
Sbjct: 872  EQWL 875


 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 56/256 (21%), Positives = 116/256 (45%), Gaps = 7/256 (2%)
 Frame = +1

Query: 49   FYRDTEQAEA---WIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDD 219
            FY    +A A   W+ ++E +L    + + L+ +E + ++ E  E  + A   +   + D
Sbjct: 854  FYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARVTAVSD 913

Query: 220  IANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAW 399
            IA +L++        +   ++ L  R       A  +K +L  + + Q +  +  E +AW
Sbjct: 914  IAEQLLKASPPGKDRIIGTQEQLNQRWQQFRSLADGKKAALTSALSIQNYHLECTETQAW 973

Query: 400  IVEKLKTASDENYKEPTNLQSKVQKHQNFLA----EIAANEGRIDDVKSRGQSLLDSDHN 567
            + EK K    E+ ++  N  + V   Q  LA    ++ A   R+ ++     +L      
Sbjct: 974  MREKTKVI--ESTQDLGNDLAGVLALQRKLAGTERDLEAISARVGELTQEANALAAGHPA 1031

Query: 568  KSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSD 747
            ++  I  R+ E+   W+DL +  + +E +L +A   Q F+R+++D + WL   ++ + S+
Sbjct: 1032 QAPAINTRLGEVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASE 1091

Query: 748  DCGKDLNSVTNLQKKH 795
            +    L     L  +H
Sbjct: 1092 EGPATLPEAEALLAQH 1107


 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 58/256 (22%), Positives = 113/256 (44%), Gaps = 3/256 (1%)
 Frame = +1

Query: 34   MDLQLFYRDTEQAEAWIAKQEAFLENN-DVGDSLDSVEALIRKHEDFEKSLAAQEEKTQR 210
            + +Q ++ +  + +AW+ ++   +E+  D+G+ L  V AL RK    E+ L A   +   
Sbjct: 958  LSIQNYHLECTETQAWMREKTKVIESTQDLGNDLAGVLALQRKLAGTERDLEAISARVGE 1017

Query: 211  LDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEI 390
            L   AN L       A  +N +  ++     +L    + R+ SL ++   Q F R  D+ 
Sbjct: 1018 LTQEANALAAGHPAQAPAINTRLGEVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDF 1077

Query: 391  KAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLL-DSDH 564
            +AW+   +   AS+E        ++ + +H     E+   +     +++ G+ +  D   
Sbjct: 1078 QAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRTLGEEVTRDQAD 1137

Query: 565  NKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGS 744
             +   ++QR+E L   W++L    + ++  L QA G Q F+R+    E  L+  E  L  
Sbjct: 1138 PQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYFLSH 1197

Query: 745  DDCGKDLNSVTNLQKK 792
             +    L +     KK
Sbjct: 1198 TEMPGTLQAADAAIKK 1213


 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 63/264 (23%), Positives = 104/264 (39%), Gaps = 2/264 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER     Q   L  F  D    EAW+      + + +VG    S +AL R+H   E+ + 
Sbjct: 738  ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQALARQHRALEEEIR 797

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            A       L + A  L     +   +V  +   L      L+ +A  R  +LE +  +  
Sbjct: 798  AHRPTLDALREQAAALPPALSH-TPEVQGRVPTLEQHYEELQARAGERARALEAALAFYT 856

Query: 367  FDRDADEIKAWIVEKLKTASDENYKEP-TNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
               +A     W+ EK +  +     E   +L+   Q+ +    E+ A   R+  V    +
Sbjct: 857  MLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARVTAVSDIAE 916

Query: 544  SLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAE 723
             LL +     D I    E+L++ W+   S +  K+  LT A   Q +     + + W+ E
Sbjct: 917  QLLKASPPGKDRIIGTQEQLNQRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMRE 976

Query: 724  VESQLGS-DDCGKDLNSVTNLQKK 792
                + S  D G DL  V  LQ+K
Sbjct: 977  KTKVIESTQDLGNDLAGVLALQRK 1000


 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 59/257 (22%), Positives = 112/257 (43%), Gaps = 4/257 (1%)
 Frame = +1

Query: 37   DLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLD 216
            +LQ F     QA A +  ++  L +   G  L++ EAL R+H  +E  + A   + Q++ 
Sbjct: 1802 ELQRFLHGARQALARVQHKQQQLPDG-TGRDLNAAEALQRRHCAYEHDIQALSTQVQQVQ 1860

Query: 217  DIANKLVENGHYA---AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADE 387
            D   +L +   YA   A ++ +    +    A L+  +  R+  L D+ +   F +   E
Sbjct: 1861 DDGLRLQKA--YAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRE 1918

Query: 388  IKAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDH 564
            +  W+    L+  + E  ++ ++    ++  Q   AEI A   R       GQ LL  +H
Sbjct: 1919 LMLWMDGINLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSACIDMGQELLARNH 1978

Query: 565  NKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGS 744
              +++I +++ +L    ++     + K   L        F R+    E WL   E  + S
Sbjct: 1979 YAAEEISEKLSQLQSRRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRS 2038

Query: 745  DDCGKDLNSVTNLQKKH 795
             + G  ++ V +L K+H
Sbjct: 2039 AELGCTVDEVESLIKRH 2055


 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 39/119 (32%), Positives = 65/119 (54%), Gaps = 3/119 (2%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W E+    +  +++ +F RD   AEAW+  QE  + + ++G ++D VE+LI++HE F+KS
Sbjct: 2002 WQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKS 2061

Query: 181  LAAQEEKTQRLDDI-ANKLVENGHYAAADVNKKRDDLLIRK--ANLEEKAKLRKGSLED 348
              A EE+   L+ + A +  EN      +  +KR++   RK     E  A   +GSL D
Sbjct: 2062 AVAWEERFSALEKLTALEEREN------EQKRKREEEERRKQPPTSEPMASQPEGSLVD 2114


 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 40/198 (20%), Positives = 86/198 (43%), Gaps = 1/198 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR L     D   F++   +   W+      ++  +    + S + +I+  +  +  + A
Sbjct: 1899 RRQLLLDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSADLVIKNQQGIKAEIEA 1958

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
            + ++     D+  +L+   HYAA ++++K   L  R+    EK + +   L+      +F
Sbjct: 1959 RADRFSACIDMGQELLARNHYAAEEISEKLSQLQSRRQETAEKWQEKMDWLQLVLEVLVF 2018

Query: 370  DRDADEIKAWIV-EKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
             RDA   +AW+  ++    S E       ++S +++H+ F     A E R     S  + 
Sbjct: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERF----SALEK 2074

Query: 547  LLDSDHNKSDDIQQRIEE 600
            L   +  +++  ++R EE
Sbjct: 2075 LTALEERENEQKRKREEE 2092


 Score = 38.1 bits (87), Expect = 0.028
 Identities = 39/178 (21%), Positives = 75/178 (42%), Gaps = 20/178 (11%)
 Frame = +1

Query: 322 KLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASD----------ENYKEPTNLQSKVQ 471
           K+   ++E  H  + ++  A E+  WI + + T +D          +N  +  N    V+
Sbjct: 295 KVLDHAMEAEHLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVE 354

Query: 472 KHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQR--IEELDKLWKDLVSASKIK 645
           K   F       +G ++ +    QS L +++ K    ++   I +++K W+ L  A   +
Sbjct: 355 KPPKF-----TEKGNLEVLLFTIQSKLRANNQKVYTpreGRLISDINKAWERLEKAEHER 409

Query: 646 ETNLTQASGQQQ--------FIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKH 795
           E  L     +Q+        F R     E WL+E +  +  D+ G +L +V    +KH
Sbjct: 410 ELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKH 467

>sp|O15020|SPTN2_HUMAN Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2)
            (Beta-III spectrin)
          Length = 2390

 Score =  154 bits (390), Expect = 2e-37
 Identities = 89/264 (33%), Positives = 141/264 (53%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W  R+    Q    Q F RD  QAE  ++ QE  L + ++  +L + +A I+K EDF  +
Sbjct: 1161 WESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMST 1220

Query: 181  LAAQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNY 360
            + A  E+   L +   +LV  G+  A  + +K D +  R    ++ A+   G L D+   
Sbjct: 1221 MDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQ 1280

Query: 361  QLFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRG 540
            Q F +D  E+K WI EK+ TA D +Y E  NL +K QKHQ F+AE+AAN+  +D V   G
Sbjct: 1281 QHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEG 1340

Query: 541  QSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
            + L          + +++ +L + W +L + ++ K  +L  A+  + F ++   +E WL 
Sbjct: 1341 RELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLE 1400

Query: 721  EVESQLGSDDCGKDLNSVTNLQKK 792
             +++QL SDD GKDL SV  L KK
Sbjct: 1401 SLQAQLHSDDYGKDLTSVNILLKK 1424


 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 69/262 (26%), Positives = 123/262 (46%), Gaps = 1/262 (0%)
 Frame = +1

Query: 13   RFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQ 192
            R L++ N   +LF +     E+W+   +A L ++D G  L SV  L++K +  E  +A +
Sbjct: 1377 RSLFDANR-AELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVR 1435

Query: 193  EEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFD 372
            E++ + +   A  L +     A +V +    +  +   L +  + R   L+ S     F 
Sbjct: 1436 EKEVEAIQAQAKALAQEDQ-GAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFH 1494

Query: 373  RDADEIKAWIVEKLKTASD-ENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSL 549
            RD ++   W+ E+L  AS  E+ K+  ++Q  ++K+Q    EI  +E RI D++ R ++L
Sbjct: 1495 RDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL 1554

Query: 550  LDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVE 729
                   +      + EL ++WK L    +++   L  A   QQF R+  + E W+ E E
Sbjct: 1555 ------GAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQE 1608

Query: 730  SQLGSDDCGKDLNSVTNLQKKH 795
              +   +  KD  S     KKH
Sbjct: 1609 LHMMGQEKAKDELSAQAEVKKH 1630


 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 68/260 (26%), Positives = 116/260 (44%), Gaps = 5/260 (1%)
 Frame = +1

Query: 31   NMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQR 210
            N++LQ  ++D      W+ + +  L++ D+G  L  VE L++ HE  E  +A Q E+ + 
Sbjct: 530  NLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRA 589

Query: 211  LDDIANKLVENG-HYAAAD---VNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRD 378
            +   A +    G  Y   D   V+++   L      L E A  R+  LE+S     F  +
Sbjct: 590  VSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWE 649

Query: 379  ADEIKAWIVEKLKT-ASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLD 555
              E +AW+ E+    AS +  ++ T     + KH     E++   G +     +GQ L+ 
Sbjct: 650  VGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVA 709

Query: 556  SDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQ 735
              H  +     R  EL   W+ L + ++ +   L QA+   QF  +  DME WL +    
Sbjct: 710  EGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRL 769

Query: 736  LGSDDCGKDLNSVTNLQKKH 795
            + S + G D  S   L ++H
Sbjct: 770  VSSPELGHDEFSTQALARQH 789


 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 60/261 (22%), Positives = 121/261 (46%), Gaps = 4/261 (1%)
 Frame = +1

Query: 25   EQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKT 204
            E  +  Q FYRD  +AEAW+ +QE  +   +      S +A ++KH+  E++LA   +  
Sbjct: 1585 EDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTI 1644

Query: 205  QRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDAD 384
             +L   +  ++++ H  +  ++ ++  +    A L+E A  R+  L++        R+ D
Sbjct: 1645 HQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELD 1704

Query: 385  EIKAWIVEKLKTASD----ENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLL 552
            +++ WI E+   A+     ++Y+  T L+ K ++     + I   + R+D   +    L+
Sbjct: 1705 DLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTI--GQERVDSANALANGLI 1762

Query: 553  DSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVES 732
               H     + +  + L++ W DL+     +   L  A   Q+F+         +   + 
Sbjct: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQ 1822

Query: 733  QLGSDDCGKDLNSVTNLQKKH 795
            QL  D  G+DLN+   LQ++H
Sbjct: 1823 QL-PDGTGRDLNAAEALQRRH 1842


 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 65/257 (25%), Positives = 125/257 (48%), Gaps = 2/257 (0%)
 Frame = +1

Query: 31   NMDLQLFYRDTEQAEAWIAKQEAFLENNDVG-DSLDSVEALIRKHEDFEKSLAAQEEKTQ 207
            N + Q F +D  + + WI   E  L   DV  D   ++    +KH+ F   LAA ++   
Sbjct: 1277 NREQQHFLQDCHELKLWI--DEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLD 1334

Query: 208  RLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADE 387
            ++D    +L        A V++K  DL  R   LE   + +  SL D++  +LF +    
Sbjct: 1335 KVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCA 1394

Query: 388  IKAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDH 564
            +++W+   + +  SD+  K+ T++   ++K Q    E+A  E  ++ ++++ ++L   D 
Sbjct: 1395 LESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ 1454

Query: 565  NKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGS 744
              + ++++    +++ ++ L    + +   L  +  Q QF R+VED  +W+ E      S
Sbjct: 1455 G-AGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASS 1513

Query: 745  DDCGKDLNSVTNLQKKH 795
             + GKDL SV  L KK+
Sbjct: 1514 MEHGKDLPSVQLLMKKN 1530


 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 56/257 (21%), Positives = 122/257 (47%), Gaps = 2/257 (0%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ERR   ++++ L    R+ +  E WI ++E    ++++G   + V  L  K  +F +  +
Sbjct: 1685 ERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTS 1744

Query: 187  A-QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQ 363
               +E+    + +AN L+  GH A A V + +D L    A+L E    R   L  ++  Q
Sbjct: 1745 TIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQ 1804

Query: 364  LFDRDADEIKAWIVEKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQ 543
             F   A +  A +  K +   D   ++    ++  ++H  +  +I A   ++  V+  G 
Sbjct: 1805 RFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGH 1864

Query: 544  SLLDS-DHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLA 720
             L  +   +K+++I + ++ + + W  L  +S  +   L   + + +F + V ++ +W+ 
Sbjct: 1865 RLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMD 1924

Query: 721  EVESQLGSDDCGKDLNS 771
            EV  Q+ + +  +D++S
Sbjct: 1925 EVNLQMDAQERPRDVSS 1941


 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 53/244 (21%), Positives = 114/244 (46%), Gaps = 1/244 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR   E++  L  F  +  +AEAW+ +Q+  L + D G  L     L+ KH      ++ 
Sbjct: 633  RRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSG 692

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
            +    +   +   +LV  GH  A+  + +  +L  +   LE  A+ R   L  + +   F
Sbjct: 693  RLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQF 752

Query: 370  DRDADEIKAWIVEKLK-TASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQS 546
              DA++++AW+V+ L+  +S E   +  + Q+  ++H+    EI ++   +D ++ +  +
Sbjct: 753  QADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQA-A 811

Query: 547  LLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEV 726
             L    +++ ++Q R+  L++ +++L + +  +   L  A      +       +W+ E 
Sbjct: 812  ALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEK 871

Query: 727  ESQL 738
            E  L
Sbjct: 872  EQWL 875


 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 54/254 (21%), Positives = 112/254 (44%), Gaps = 5/254 (1%)
 Frame = +1

Query: 49   FYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLDDIAN 228
            F R     E W+++ +  +  ++ G  L +VEA +RKHE  E  + A   + Q +D +A 
Sbjct: 430  FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAA 489

Query: 229  KLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEIKAWIVE 408
            +L    ++    +  ++ ++      L +    R+  L  +   Q   +D   +  W+ E
Sbjct: 490  ELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEE 549

Query: 409  -KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLD--SDHNKSDD 579
             K +  S +  +    ++  +Q H+   A+IA    R+  V +      +   ++   D 
Sbjct: 550  MKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDP 609

Query: 580  --IQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGSDDC 753
              + +R+ +L++ ++ L   +  +   L ++    +F+  V + E W+ E +  L S D 
Sbjct: 610  QLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADT 669

Query: 754  GKDLNSVTNLQKKH 795
            G+DL     L  KH
Sbjct: 670  GRDLTGALRLLNKH 683


 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 55/268 (20%), Positives = 114/268 (42%), Gaps = 5/268 (1%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER    E  + L     +      W+ ++E +L    + + L+ +E + ++ E  E  + 
Sbjct: 843  ERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMN 902

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
                +   ++DIA +L++        +   ++ L  R       A  +K +L  + + Q 
Sbjct: 903  TLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQN 962

Query: 367  FDRDADEIKAWIVEKLKTASD-----ENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVK 531
            +  +  E +AW+ EK K          +      LQ K+   +  L  IAA   R+ ++ 
Sbjct: 963  YHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAA---RVGELT 1019

Query: 532  SRGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEI 711
                +L      ++  I  R+ E+   W+DL +  + +E +L +A   Q F+R+++D + 
Sbjct: 1020 REANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQA 1079

Query: 712  WLAEVESQLGSDDCGKDLNSVTNLQKKH 795
            WL   ++ + S++    L     L  +H
Sbjct: 1080 WLGRTQTAVASEEGPATLPEAEALLAQH 1107


 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 57/256 (22%), Positives = 112/256 (43%), Gaps = 3/256 (1%)
 Frame = +1

Query: 34   MDLQLFYRDTEQAEAWIAKQEAFLENND-VGDSLDSVEALIRKHEDFEKSLAAQEEKTQR 210
            + +Q ++ +  + +AW+ ++   +E+   +G+ L  V AL RK    E+ L A   +   
Sbjct: 958  LSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGE 1017

Query: 211  LDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADEI 390
            L   AN L       A  +N +  ++     +L    + R+ SL ++   Q F R  D+ 
Sbjct: 1018 LTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDF 1077

Query: 391  KAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLL-DSDH 564
            +AW+   +   AS+E        ++ + +H     E+   +     +++ G+ +  D   
Sbjct: 1078 QAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQAD 1137

Query: 565  NKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGS 744
             +   ++QR+E L   W++L    + ++  L QA G Q F+R+    E  L+  E  L  
Sbjct: 1138 PQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSH 1197

Query: 745  DDCGKDLNSVTNLQKK 792
             +    L +     KK
Sbjct: 1198 TEMPGTLQAADAAIKK 1213


 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 59/257 (22%), Positives = 113/257 (43%), Gaps = 4/257 (1%)
 Frame = +1

Query: 37   DLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAAQEEKTQRLD 216
            +LQ F     QA A +  ++  L +   G  L++ EAL R+H  +E  + A   + Q++ 
Sbjct: 1802 ELQRFLHGARQALARVQHKQQQLPDG-TGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQ 1860

Query: 217  DIANKLVENGHYA---AADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLFDRDADE 387
            D  ++L +   YA   A ++ +    +    A L+  +  R+  L D+ +   F +   E
Sbjct: 1861 DDGHRLQKA--YAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRE 1918

Query: 388  IKAWIVE-KLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKSRGQSLLDSDH 564
            +  W+ E  L+  + E  ++ ++    ++  Q   AEI A   R       G+ LL   H
Sbjct: 1919 LMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSH 1978

Query: 565  NKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIWLAEVESQLGS 744
              +++I +++ +L    ++     + K   L        F R+    E WL   E  + S
Sbjct: 1979 YAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRS 2038

Query: 745  DDCGKDLNSVTNLQKKH 795
             + G  ++ V +L K+H
Sbjct: 2039 AELGCTVDEVESLIKRH 2055


 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 26/74 (35%), Positives = 46/74 (62%)
 Frame = +1

Query: 1    WNERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKS 180
            W E+    +  +++ +F RD   AEAW+  QE  + + ++G ++D VE+LI++HE F+KS
Sbjct: 2002 WQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKS 2061

Query: 181  LAAQEEKTQRLDDI 222
              A EE+   L+ +
Sbjct: 2062 AVAWEERFCALEKL 2075


 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 58/267 (21%), Positives = 103/267 (38%), Gaps = 5/267 (1%)
 Frame = +1

Query: 7    ERRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLA 186
            ER     Q   L  F  D    EAW+      + + ++G    S +AL R+H   E+ + 
Sbjct: 738  ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIR 797

Query: 187  AQEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQL 366
            +       L + A  L         +V  +   L      L+ +A  R  +LE +     
Sbjct: 798  SHRPTLDALREQAAALPPT-LSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYT 856

Query: 367  FDRDADEIKAWIVEKLK----TASDENYKEPTNLQSKVQKHQNFLAEIAANEGRIDDVKS 534
               +A     W+ EK +     A  E  ++   +Q + +  +  +  +AA    ++D+  
Sbjct: 857  MLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDI-- 914

Query: 535  RGQSLLDSDHNKSDDIQQRIEELDKLWKDLVSASKIKETNLTQASGQQQFIRNVEDMEIW 714
              + LL ++    D I    E+L+  W+     +  K+  LT A   Q +     + + W
Sbjct: 915  -AEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973

Query: 715  LAEVESQLGS-DDCGKDLNSVTNLQKK 792
            + E    + S    G DL  V  LQ+K
Sbjct: 974  MREKTKVIESTQGLGNDLAGVLALQRK 1000


 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 35/170 (20%), Positives = 75/170 (44%), Gaps = 1/170 (0%)
 Frame = +1

Query: 10   RRFLYEQNMDLQLFYRDTEQAEAWIAKQEAFLENNDVGDSLDSVEALIRKHEDFEKSLAA 189
            RR L     D   F++   +   W+ +    ++  +    + S + +I+  +  +  + A
Sbjct: 1899 RRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEA 1958

Query: 190  QEEKTQRLDDIANKLVENGHYAAADVNKKRDDLLIRKANLEEKAKLRKGSLEDSHNYQLF 369
            + ++     D+  +L+   HYAA ++++K   L  R+    EK + +   L+      +F
Sbjct: 1959 RADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVF 2018

Query: 370  DRDADEIKAWIV-EKLKTASDENYKEPTNLQSKVQKHQNFLAEIAANEGR 516
             RDA   +AW+  ++    S E       ++S +++H+ F     A E R
Sbjct: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEER 2068


 Score = 35.0 bits (79), Expect = 0.24
 Identities = 38/178 (21%), Positives = 74/178 (41%), Gaps = 20/178 (11%)
 Frame = +1

Query: 322 KLRKGSLEDSHNYQLFDRDADEIKAWIVEKLKTASD----------ENYKEPTNLQSKVQ 471
           K+   ++E     + ++  A E+  WI + + T +D          +N  +  N    V+
Sbjct: 295 KVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVE 354

Query: 472 KHQNFLAEIAANEGRIDDVKSRGQSLLDSDHNKSDDIQQR--IEELDKLWKDLVSASKIK 645
           K   F       +G ++ +    QS L +++ K    ++   I +++K W+ L  A   +
Sbjct: 355 KPPKF-----TEKGNLEVLLFTIQSKLRANNQKVYTpreGRLISDINKAWERLEKAEHER 409

Query: 646 ETNLTQASGQQQ--------FIRNVEDMEIWLAEVESQLGSDDCGKDLNSVTNLQKKH 795
           E  L     +Q+        F R     E WL+E +  +  D+ G +L +V    +KH
Sbjct: 410 ELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKH 467

  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.310    0.127    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,184,063
Number of Sequences: 369166
Number of extensions: 1509566
Number of successful extensions: 5341
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4468
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5037
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7570361805
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)

Planarian EST Database

Dr_sW_008_I09

BLASTX 2.2.12 [Aug-07-2005]