Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_H21
(697 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9HCC0|MCCC2_HUMAN Methylcrotonoyl-CoA carboxylase beta ... 329 5e-90
sp|Q9V9A7|PCCB_DROME Putative propionyl-CoA carboxylase bet... 312 6e-85
sp|P34385|YLPC_CAEEL Hypothetical protein F02A9.4a in chrom... 294 2e-79
sp|Q9LDD8|MCCB_ARATH Methylcrotonoyl-CoA carboxylase beta c... 254 2e-67
sp|Q8GBW6|12S_PROFR Methylmalonyl-CoA carboxyltransferase 1... 104 2e-22
sp|Q06700|GCDA_ACIFE Glutaconyl-CoA decarboxylase alpha sub... 103 4e-22
sp|P53002|PCCB_MYCLE Probable propionyl-CoA carboxylase bet... 98 2e-20
sp|P96885|PCC5_MYCTU Probable propionyl-CoA carboxylase bet... 95 2e-19
sp|P54541|PCCB_BACSU Putative propionyl-CoA carboxylase bet... 95 2e-19
sp|P53003|PCCB_SACER Propionyl-CoA carboxylase beta chain (... 94 3e-19
>sp|Q9HCC0|MCCC2_HUMAN Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor
(3-Methylcrotonyl-CoA carboxylase 2) (MCCase beta
subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase
beta subunit) (3-Methylcrotonyl-CoA carboxylase
non-biotin-containing subunit)
Length = 563
Score = 329 bits (843), Expect = 5e-90
Identities = 156/226 (69%), Positives = 189/226 (83%)
Frame = +3
Query: 3 GRINGIECMITSNDPTVKGGSYYPITVKKHLRAQEFAKENNLPFIYLVDSGGINLPRQSN 182
GR++G+ECMI +ND TVKGG+YYP+TVKK LRAQE A +N LP IYLVDSGG LPRQ++
Sbjct: 124 GRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPRQAD 183
Query: 183 VFPDRDHVGRLFYNQANLSADRIPQIAVVLGSCTAGGAYISTMVDQSVIVRNQGTIYLAG 362
VFPDRDH GR FYNQA +S+ I QIAVV+GSCTAGGAY+ M D+++IVR QGTI+LAG
Sbjct: 184 VFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIFLAG 243
Query: 363 PPLVKAATGETISAEDLGGADLHCRQSGVIDHYATSDRDAIYITRSIVRNLNRKKRMSVA 542
PPLVKAATGE +SAEDLGGADLHCR+SGV DH+A D A+++TR +VRNLN +K++ V
Sbjct: 244 PPLVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKKLDVT 303
Query: 543 FEKPEPPRYPADELYGIVGANLKRTFNMYEVIARIVDGSKMQEFQA 680
E E P +PADELYGIVGANLKR+F++ EVIARIVDGS+ EF+A
Sbjct: 304 IEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKA 349
>sp|Q9V9A7|PCCB_DROME Putative propionyl-CoA carboxylase beta chain, mitochondrial
precursor (PCCase beta subunit) (Propanoyl-CoA:carbon
dioxide ligase beta subunit)
Length = 578
Score = 312 bits (799), Expect = 6e-85
Identities = 156/243 (64%), Positives = 185/243 (76%), Gaps = 16/243 (6%)
Frame = +3
Query: 3 GRINGIECMITSNDPTVKGGSYYPITVKKHLRAQEFAKENNLPFIYLVDSGGINLPRQSN 182
GR+ G EC++ +ND TVKGGSYYPITVKKHLRAQE A+EN LP IYLVDSGG NLPRQ++
Sbjct: 123 GRVCGTECLVVANDATVKGGSYYPITVKKHLRAQEIAQENRLPCIYLVDSGGANLPRQAD 182
Query: 183 VFPDRDHVGRLFYNQANLSADRIPQIAVVLGSCTAGGAYISTMVDQSVIVRNQGTIYLAG 362
VFPD+ H GR+FYNQAN+SA IPQIAVV+GSCTAGGAY+ M D+S+IV+ QGTI+LAG
Sbjct: 183 VFPDKLHFGRIFYNQANMSAQGIPQIAVVMGSCTAGGAYVPAMADESIIVKKQGTIFLAG 242
Query: 363 PPLVKAATGETISAEDLGGADLHCRQSGVIDHYATSDRDAIYITRSIVRNLNRKKRMS-- 536
PPLVKAATGE +SAEDLGGADLHC+ SGV DHYA D A+Y+ R IV NLN S
Sbjct: 243 PPLVKAATGEEVSAEDLGGADLHCKTSGVTDHYALDDEHALYLARQIVSNLNLSATNSYN 302
Query: 537 --------VAFEKPEP------PRYPADELYGIVGANLKRTFNMYEVIARIVDGSKMQEF 674
V F+ P PRY A+ELYGIVG NL ++F++ EVIARIVDGS+ EF
Sbjct: 303 DQLMHSSQVNFQTATPPSAVEEPRYDAEELYGIVGPNLTKSFDVREVIARIVDGSRFTEF 362
Query: 675 QAI 683
+ +
Sbjct: 363 KKL 365
>sp|P34385|YLPC_CAEEL Hypothetical protein F02A9.4a in chromosome III
Length = 608
Score = 294 bits (752), Expect = 2e-79
Identities = 138/225 (61%), Positives = 178/225 (79%)
Frame = +3
Query: 3 GRINGIECMITSNDPTVKGGSYYPITVKKHLRAQEFAKENNLPFIYLVDSGGINLPRQSN 182
G ++G C+I +ND TVKGG+YYPITVKKHLRAQE A+EN LP IYLVDSGG NLPRQ++
Sbjct: 169 GIVSGRVCVIVANDATVKGGTYYPITVKKHLRAQEIARENKLPCIYLVDSGGANLPRQAD 228
Query: 183 VFPDRDHVGRLFYNQANLSADRIPQIAVVLGSCTAGGAYISTMVDQSVIVRNQGTIYLAG 362
+F D H GR+FYNQA +S++ IPQ+AVV+GSCTAGGAY+ M DQ++IV+ GT++L G
Sbjct: 229 IFADSQHFGRIFYNQATMSSEGIPQLAVVMGSCTAGGAYVPAMSDQAIIVKGTGTVFLGG 288
Query: 363 PPLVKAATGETISAEDLGGADLHCRQSGVIDHYATSDRDAIYITRSIVRNLNRKKRMSVA 542
PPLVKAATGE ISAE+LGGADLHC +SGV D+YA +D+ A+Y+ RS + L +
Sbjct: 289 PPLVKAATGEEISAEELGGADLHCGESGVTDYYAHNDKHALYLARSCIAGLPPVEEHMTF 348
Query: 543 FEKPEPPRYPADELYGIVGANLKRTFNMYEVIARIVDGSKMQEFQ 677
+ P YPA+E+YGIVG+NLK+T+++ EVIARIVDGS+ EF+
Sbjct: 349 NPNADEPLYPAEEIYGIVGSNLKKTYDVREVIARIVDGSRFHEFK 393
>sp|Q9LDD8|MCCB_ARATH Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor
(3-Methylcrotonyl-CoA carboxylase 2) (MCCase beta
subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase
beta subunit)
Length = 587
Score = 254 bits (649), Expect = 2e-67
Identities = 130/231 (56%), Positives = 168/231 (72%), Gaps = 6/231 (2%)
Frame = +3
Query: 3 GRINGIECMITSNDPTVKGGSYYPITVKKHLRAQEFAKENNLPFIYLVDSGGINLPRQSN 182
G I+G CM +NDPTVKGG+YYPIT+KKHLRAQE A LP IYLVDSGG LP+Q+
Sbjct: 142 GPIHGRICMFMANDPTVKGGTYYPITIKKHLRAQEIAARCRLPCIYLVDSGGAYLPKQAE 201
Query: 183 VFPDRDHVGRLFYNQANLSADRIPQIAVVLGSCTAGGAYISTMVDQSVIVRNQGTIYLAG 362
VFPD+++ GR+FYN++ +S+D IPQIA+VLGSCTAGGAYI M D+SV+V+ GTI+LAG
Sbjct: 202 VFPDKENFGRVFYNESVMSSDGIPQIAIVLGSCTAGGAYIPAMADESVMVKGNGTIFLAG 261
Query: 363 PPLVKAATGETISAEDLGGADLHCRQSGVIDHYATSDRDAIYITRSIVRNLN--RKKRMS 536
PPLVKAATGE +SAEDLGGA +HC SGV D++A + + I R+IV+NL+ K+ M
Sbjct: 262 PPLVKAATGEEVSAEDLGGATVHCTVSGVSDYFAQDELHGLAIGRNIVKNLHMAAKQGME 321
Query: 537 VAFEKP----EPPRYPADELYGIVGANLKRTFNMYEVIARIVDGSKMQEFQ 677
F + P Y +EL I + K+ F++ +IARIVDGS+ EF+
Sbjct: 322 GTFGSKNLVYKEPLYDINELRSIAPVDHKQQFDVRSIIARIVDGSEFDEFK 372
>sp|Q8GBW6|12S_PROFR Methylmalonyl-CoA carboxyltransferase 12S subunit (Transcarboxylase
12S subunit)
Length = 611
Score = 104 bits (260), Expect = 2e-22
Identities = 69/226 (30%), Positives = 109/226 (48%)
Frame = +3
Query: 3 GRINGIECMITSNDPTVKGGSYYPITVKKHLRAQEFAKENNLPFIYLVDSGGINLPRQSN 182
G I G S D TV GGS K + E A PF++ DSGG + +
Sbjct: 91 GTILGRPVHAASQDFTVMGGSAGETQSTKVVETMEQALLTGTPFLFFYDSGGARIQEGID 150
Query: 183 VFPDRDHVGRLFYNQANLSADRIPQIAVVLGSCTAGGAYISTMVDQSVIVRNQGTIYLAG 362
G++F+ LS +PQIA++ G C G +Y + D +I+ + +++ G
Sbjct: 151 SLSG---YGKMFFANVKLSGV-VPQIAIIAGPCAGGASYSPALTD-FIIMTKKAHMFITG 205
Query: 363 PPLVKAATGETISAEDLGGADLHCRQSGVIDHYATSDRDAIYITRSIVRNLNRKKRMSVA 542
P ++K+ TGE ++A++LGGA+ H SG I A D A I + ++ L + +
Sbjct: 206 PQVIKSVTGEDVTADELGGAEAHMAISGNIHFVAEDDDAAELIAKKLLSFLPQNNTEEAS 265
Query: 543 FEKPEPPRYPADELYGIVGANLKRTFNMYEVIARIVDGSKMQEFQA 680
F P P EL IV + K+ +++ +VIA+IVD E +A
Sbjct: 266 FVNPNNDVSPNTELRDIVPIDGKKGYDVRDVIAKIVDWGDYLEVKA 311
Score = 33.1 bits (74), Expect = 0.72
Identities = 27/100 (27%), Positives = 41/100 (41%)
Frame = +3
Query: 6 RINGIECMITSNDPTVKGGSYYPITVKKHLRAQEFAKENNLPFIYLVDSGGINLPRQSNV 185
R+NG I +N P+V G K F N+P + LVD G Q
Sbjct: 323 RVNGRSVGIVANQPSVMSGCLDINASDKAAEFVNFCDSFNIPLVQLVDVPGFLPGVQQEY 382
Query: 186 FPDRDHVGRLFYNQANLSADRIPQIAVVLGSCTAGGAYIS 305
H ++ Y + + +P+I VVL GG+Y++
Sbjct: 383 GGIIRHGAKMLYAYSEAT---VPKITVVLRK-AYGGSYLA 418
>sp|Q06700|GCDA_ACIFE Glutaconyl-CoA decarboxylase alpha subunit (Carboxyltransferase)
Length = 587
Score = 103 bits (257), Expect = 4e-22
Identities = 65/243 (26%), Positives = 115/243 (47%), Gaps = 18/243 (7%)
Frame = +3
Query: 3 GRINGIECMITSNDPTVKGGSYYPITVKKHLRAQEFAKENNLPFIYLVDSGGINLPRQSN 182
GR+NG C++ ++D G++ P + LRA + AK ++P +Y+++ G+ Q
Sbjct: 100 GRVNGKWCVVVASDNKKLAGAWVPGQAECLLRASDTAKTLHVPLVYVLNCSGVKFDEQEK 159
Query: 183 VFPDRDHVGRLFYNQANLSADRIPQIAVVLGSCTAGGAYISTMVDQSVIVRNQ------- 341
V+P+R G F+ A L+ IP I + G+ AGG Y S + +VI+ ++
Sbjct: 160 VYPNRRGGGTPFFRNAELNQLGIPVIVGIYGTNPAGGGYHS--ISPTVIIAHEKANMAVG 217
Query: 342 -----------GTIYLAGPPLVKAATGETISAEDLGGADLHCRQSGVIDHYATSDRDAIY 488
G + L + T E G D+H ++G + S+ +
Sbjct: 218 GAGIMGGMNPKGHVDLEYANEIADMVDRTGKTEPPGAVDIHYTETGFMREVYASEEGVLE 277
Query: 489 ITRSIVRNLNRKKRMSVAFEKPEPPRYPADELYGIVGANLKRTFNMYEVIARIVDGSKMQ 668
+ V L + + P+ P +PAD+LY +V N KR +++Y VIAR+ D S++
Sbjct: 278 GIKKYVGMLPKYDPEFFRVDDPKAPAFPADDLYSMVPLNDKRAYDIYNVIARLFDNSELH 337
Query: 669 EFQ 677
E++
Sbjct: 338 EYK 340
>sp|P53002|PCCB_MYCLE Probable propionyl-CoA carboxylase beta chain 5 (PCCase)
(Propanoyl-CoA:carbon dioxide ligase)
Length = 549
Score = 97.8 bits (242), Expect = 2e-20
Identities = 68/234 (29%), Positives = 116/234 (49%), Gaps = 8/234 (3%)
Frame = +3
Query: 3 GRINGIECMITSNDPTVKGGSYYPITVKKHLRAQEFAKENNLPFIYLVDSGGINLPRQSN 182
G I+G + I S D TV GGS + +K ++ QE A + P I + D G + Q
Sbjct: 103 GTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARI--QEG 160
Query: 183 VFPDRDHVGRLFYNQANLSADRIPQIAVVLGSCTAGGAYISTMVDQSVIVRNQGTIYLAG 362
V R+F N L++ IPQI++++G+ G Y + D V+V +++ G
Sbjct: 161 VV-SLGLYSRIFRNNI-LASGVIPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITG 218
Query: 363 PPLVKAATGETISAEDLGGADLHCRQSGVIDHYATSDRDAIYITRSIVRNL-NRKKRMSV 539
P ++K TGE ++ E+LGGA H +SG + A+ ++DA R ++ L + +
Sbjct: 219 PDVIKTVTGEDVTMEELGGAHTHMAKSGTAHYVASGEQDAFDWVRDVLSYLPSNNFTDAP 278
Query: 540 AFEKPEPPRYPAD-------ELYGIVGANLKRTFNMYEVIARIVDGSKMQEFQA 680
+ KP P D EL ++ + + ++M+EV+ R++D + E QA
Sbjct: 279 RYSKPVPHGSIEDNLTAKDLELDTLIPDSPNQPYDMHEVVTRLLDEEEFLEVQA 332
>sp|P96885|PCC5_MYCTU Probable propionyl-CoA carboxylase beta chain 5 (PCCase)
(Propanoyl-CoA:carbon dioxide ligase)
Length = 548
Score = 94.7 bits (234), Expect = 2e-19
Identities = 66/234 (28%), Positives = 113/234 (48%), Gaps = 8/234 (3%)
Frame = +3
Query: 3 GRINGIECMITSNDPTVKGGSYYPITVKKHLRAQEFAKENNLPFIYLVDSGGINLPRQSN 182
G I+G + I S D TV GGS + +K ++ QE A + P I + D G + Q
Sbjct: 103 GTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARI--QEG 160
Query: 183 VFPDRDHVGRLFYNQANLSADRIPQIAVVLGSCTAGGAYISTMVDQSVIVRNQGTIYLAG 362
V R+F N L++ IPQI++++G+ G Y + D ++V +++ G
Sbjct: 161 VV-SLGLYSRIFRNNI-LASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITG 218
Query: 363 PPLVKAATGETISAEDLGGADLHCRQSGVIDHYATSDRDAIYITRSIVRNLNRKKRMSVA 542
P ++K TGE ++ E+LGGA H +SG + A+ ++DA R ++ L
Sbjct: 219 PDVIKTVTGEEVTMEELGGAHTHMAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTDAP 278
Query: 543 FEKPEPPRYPAD--------ELYGIVGANLKRTFNMYEVIARIVDGSKMQEFQA 680
+ P P + EL ++ + + ++M+EVI R++D + E QA
Sbjct: 279 RYQAAAPTGPIEENLTDEDLELDTLIPDSPNQPYDMHEVITRLLD-DEFLEIQA 331
>sp|P54541|PCCB_BACSU Putative propionyl-CoA carboxylase beta chain (PCCase)
(Propanoyl-CoA:carbon dioxide ligase)
Length = 506
Score = 94.7 bits (234), Expect = 2e-19
Identities = 65/232 (28%), Positives = 108/232 (46%), Gaps = 1/232 (0%)
Frame = +3
Query: 3 GRINGIECMITSNDPTVKGGSYYPITVKKHLRAQEFAKENNLPFIYLVDSGGINLPRQSN 182
G I+G + + D TV GG+ +K + A +N P I L DSGG + Q
Sbjct: 75 GTIDGRSVYVFAQDFTVYGGALGETHARKICALMDLAAKNKAPIIGLNDSGGARI--QEG 132
Query: 183 VFPDRDHVGRLFYNQANLSADRIPQIAVVLGSCTAGGAYISTMVDQSVIVRNQGTIYLAG 362
V D G +FY L + IPQI+V+LG C G Y + D + G +++ G
Sbjct: 133 VL-SLDGYGHIFYRNV-LYSGVIPQISVILGPCAGGAVYSPALTDFIFMAEQTGRMFITG 190
Query: 363 PPLVKAATGETISAEDLGGADLHCRQSGVIDHYATSDRDAIYITRSIVRNLNRKKRMSVA 542
P +++ TGE + AE LGGA +H SG ++++ + R ++ L R +
Sbjct: 191 PKVIEKVTGEQVDAESLGGAGIHNAVSGNAHFSGHTEKEVLTGVRKLLSYLPLNGRTT-- 248
Query: 543 FEKPEPPRYPADELYG-IVGANLKRTFNMYEVIARIVDGSKMQEFQAIIWRN 695
+P+P + + L +V A+ + +++ +VI + D E Q +N
Sbjct: 249 --EPKPEKEASRPLLNRLVPADTTKPYDVRKVIRELADPQSFFEIQPFFAKN 298
>sp|P53003|PCCB_SACER Propionyl-CoA carboxylase beta chain (PCCase) (Propanoyl-CoA:carbon
dioxide ligase)
Length = 546
Score = 94.4 bits (233), Expect = 3e-19
Identities = 69/247 (27%), Positives = 112/247 (45%), Gaps = 16/247 (6%)
Frame = +3
Query: 3 GRINGIECMITSNDPTVKGGSYYPITVKKHLRAQEFAKENNLPFIYLVDSGGINLPR--- 173
G ++G + S D TV GGS + +K ++ + A + P + + DSGG +
Sbjct: 99 GTVDGRRVCVFSQDFTVFGGSLGEVFGEKIVKVMDLAMKTGCPLVGINDSGGARIQEGVA 158
Query: 174 ----QSNVFPDRDHVGRLFYNQANLSADRIPQIAVVLGSCTAGGAYISTMVDQSVIVRNQ 341
+ +F H + IPQI++++G C G Y + D +V+V
Sbjct: 159 ALGLYAEIFKRNTHASGV-----------IPQISLIMGPCAGGAVYSPAITDFTVMVDQT 207
Query: 342 GTIYLAGPPLVKAATGETISAEDLGGADLHCRQSGVIDHYATSDRDAIYITRSIVRNL-N 518
+++ GP ++K TGE +S EDLGGA H +SG + AT + DAI + ++ L +
Sbjct: 208 SHMFITGPDVIKTVTGEDVSFEDLGGARTHNERSGNAHYLATDEDDAISYVKELLSFLPS 267
Query: 519 RKKRMSVAFEKPEPPR-YPAD-------ELYGIVGANLKRTFNMYEVIARIVDGSKMQEF 674
S F E AD EL +V + + ++M EVI R+VD + E
Sbjct: 268 NNLSSSPVFPGAEVEEGSVADGVGDADLELDALVPDSPNQPYDMREVITRLVDEGEFLEV 327
Query: 675 QAIIWRN 695
A+ N
Sbjct: 328 SALFAPN 334
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,728,593
Number of Sequences: 369166
Number of extensions: 1602723
Number of successful extensions: 4195
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4087
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4178
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6024953540
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)