Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_H14
(912 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q91XW8|FKBP6_MOUSE FK506-binding protein 6 (Peptidyl-pro... 112 1e-24
sp|O75344|FKBP6_HUMAN FK506-binding protein 6 (Peptidyl-pro... 104 3e-22
sp|Q38931|FKB70_ARATH 70 kDa peptidylprolyl isomerase (Pept... 65 3e-10
sp|Q02790|FKBP4_HUMAN FK506-binding protein 4 (Peptidyl-pro... 59 2e-08
sp|Q43207|FKB70_WHEAT 70 kDa peptidylprolyl isomerase (Pept... 59 2e-08
sp|P27124|FKBP4_RABIT FK506-binding protein 4 (Peptidyl-pro... 59 2e-08
sp|Q13451|FKBP5_HUMAN FK506-binding protein 5 (Peptidyl-pro... 55 4e-07
sp|Q64378|FKBP5_MOUSE FK506-binding protein 5 (Peptidyl-pro... 55 4e-07
sp|Q5RF88|FKBP5_PONPY FK506-binding protein 5 (Peptidyl-pro... 55 4e-07
sp|Q9XT11|FKBP5_AOTNA FK506-binding protein 5 (Peptidyl-pro... 54 5e-07
>sp|Q91XW8|FKBP6_MOUSE FK506-binding protein 6 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (36 kDa FK506 binding protein)
(FKBP-36) (Immunophilin FKBP36)
Length = 327
Score = 112 bits (280), Expect = 1e-24
Identities = 69/221 (31%), Positives = 116/221 (52%)
Frame = +2
Query: 209 YKNIASKMTDISGGQKLIFKRLISKGEGSKAPEGSLVIYNYKFYCEPEPEPFDSTRFKKR 388
Y+ ++ +M DISG + ++ K +I +G G + V+ Y Y E +PFDS F+K
Sbjct: 22 YERLSQRMLDISGDRGVL-KDIIREGTGDTVTPDASVLVKYSGYLEHMDKPFDSNCFRKT 80
Query: 389 PDRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVI 568
P ++G L G+++ L SM + E A F+F + +G LG PP IP A + EIE+I
Sbjct: 81 PRLMKLGEDITLWGMELGLLSMRKGELARFLFKPAYAYGTLGCPPLIPPNATVLFEIELI 140
Query: 569 DFTEKNLIDDFFEKTVEERLELSFSDMIKLVIQCRDDANVAVRDKRFGGALNKYQRGLDI 748
DF + D F + E++ + ++K+ R+ N R RF A +Y+R L +
Sbjct: 141 DFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKVRYKRALLL 200
Query: 749 LYSMPICTDDEERIRSGHVTKLHLNMAHCNLKLNRGPSAIK 871
L+ + T +E+ + V + LN++ LKL+R A++
Sbjct: 201 LHRR-LATCEEQHLVEPAVLLVLLNLSFVYLKLDRPAMALR 240
>sp|O75344|FKBP6_HUMAN FK506-binding protein 6 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (36 kDa FK506 binding protein)
(FKBP-36) (Immunophilin FKBP36)
Length = 327
Score = 104 bits (260), Expect = 3e-22
Identities = 66/220 (30%), Positives = 111/220 (50%)
Frame = +2
Query: 209 YKNIASKMTDISGGQKLIFKRLISKGEGSKAPEGSLVIYNYKFYCEPEPEPFDSTRFKKR 388
Y+ ++ +M DISG + ++ K +I +G G + V+ Y Y E PFDS F+K
Sbjct: 22 YERLSQRMLDISGDRGVL-KDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKT 80
Query: 389 PDRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVI 568
P ++G L G+++ L SM R E A F+F + +G LG PP IP + EIE++
Sbjct: 81 PRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELL 140
Query: 569 DFTEKNLIDDFFEKTVEERLELSFSDMIKLVIQCRDDANVAVRDKRFGGALNKYQRGLDI 748
DF + D F + E++ + ++K+ R+ N R RF A +Y+R L +
Sbjct: 141 DFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLL 200
Query: 749 LYSMPICTDDEERIRSGHVTKLHLNMAHCNLKLNRGPSAI 868
L +++ + + + L LN++ LKL+R A+
Sbjct: 201 LRRRSAPPEEQHLVEAAKLPVL-LNLSFTYLKLDRPTIAL 239
>sp|Q38931|FKB70_ARATH 70 kDa peptidylprolyl isomerase (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rotamase) (Peptidylprolyl isomerase
ROF1)
Length = 551
Score = 65.1 bits (157), Expect = 3e-10
Identities = 37/130 (28%), Positives = 69/130 (53%)
Frame = +2
Query: 179 NDPDSVDFPSYKNIASKMTDISGGQKLIFKRLISKGEGSKAPEGSLVIYNYKFYCEPEPE 358
ND D +DF + K+ + Q+ + K+L+ +GEG + PE + + +
Sbjct: 14 NDDDDMDFGDGASFL-KVGEEKEIQQGLKKKLLKEGEGYETPENGDEVEVHYTGTLLDGT 72
Query: 359 PFDSTRFKKRPDRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPER 538
FDS+R + P + +G GQ++ G D+ +++M + E A F + + +GE G PP IP
Sbjct: 73 KFDSSRDRATPFKFTLGQGQVIKGWDIGIKTMKKGENAVFTIPAELAYGESGSPPTIPAN 132
Query: 539 ADIYAEIEVI 568
A + ++E++
Sbjct: 133 ATLQFDVELL 142
Score = 50.4 bits (119), Expect = 7e-06
Identities = 58/259 (22%), Positives = 116/259 (44%), Gaps = 19/259 (7%)
Frame = +2
Query: 191 SVDFPSYKNIASKMTDISGGQKLIFKRLISKGEGSKAP-EGSLV------------IYNY 331
+++ S+K + S++TD + K+++ +G+G + P EG++V ++
Sbjct: 255 NLELVSWKTV-SEVTD----DNKVVKKVLKEGDGYERPNEGAVVKVKLIGKLQDGTVFLK 309
Query: 332 KFYCEPEPEPFDSTRFKKRPDRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFG-- 505
K + E E EPF+ FK + Q++ GLD A+ M + E A D FG
Sbjct: 310 KGHGENE-EPFE---FKTDEE-------QVVDGLDRAVMKMKKGEVALVTIDPEYAFGSN 358
Query: 506 ----ELGVPPRIPERADIYAEIEVIDFTEKNLIDDFFEKTVEERLELSFSDMIKLVIQCR 673
EL V +P + + E++++ F ++ + ++ EE++E + +
Sbjct: 359 ESQQELAV---VPPNSTVTYEVDLLTFDKER---ESWDMNTEEKIEAASKK--------K 404
Query: 674 DDANVAVRDKRFGGALNKYQRGLDILYSMPICTDDEERIRSGHVTKLHLNMAHCNLKLNR 853
++ N + ++ A +Y++ + + +++E++ +LN A C LKL
Sbjct: 405 EEGNSKFKGGKYSLASKRYEKAVKFIEYDTSFSEEEKKQAKALKVACNLNDAACKLKLKD 464
Query: 854 GPSAIKCCNVVLGKQPHNV 910
A K C VL + NV
Sbjct: 465 YKQAEKLCTKVLELESTNV 483
>sp|Q02790|FKBP4_HUMAN FK506-binding protein 4 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (p59 protein) (HSP binding
immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506
binding protein) (FKBP59)
Length = 459
Score = 58.9 bits (141), Expect = 2e-08
Identities = 57/222 (25%), Positives = 104/222 (46%), Gaps = 6/222 (2%)
Frame = +2
Query: 260 IFKRLISKGEGSKAP-EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQLLP--- 427
I +R+ ++GEG P EG++V + Y + F +R R +G G+ L
Sbjct: 150 IIRRIQTRGEGYAKPNEGAIVEVALEGY-------YKDKLFDQRELRFEIGEGENLDLPY 202
Query: 428 GLDVALQSMSRKERAHFVFDSSVMFGELGVPP-RIPERADIYAEIEVIDFTEKNLIDDFF 604
GL+ A+Q M + E + S FG +G +IP A++ E+ + F + + +
Sbjct: 203 GLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAK---ESW 259
Query: 605 EKTVEERLELSFSDMIKLVIQCRDDANVAVRDKRFGGALNKYQRGLDIL-YSMPICTDDE 781
E EE+LE S ++ V ++ ++ AL +Y++ + L Y ++
Sbjct: 260 EMNSEEKLEQSTI--------VKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEA 311
Query: 782 ERIRSGHVTKLHLNMAHCNLKLNRGPSAIKCCNVVLGKQPHN 907
++ ++ + HLN+A C+LKL +AI+ CN L +N
Sbjct: 312 QKAQALRLAS-HLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Score = 47.8 bits (112), Expect = 4e-05
Identities = 30/119 (25%), Positives = 56/119 (47%), Gaps = 6/119 (5%)
Frame = +2
Query: 260 IFKRLISKGEGSKAPE-GSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQR-----VGVGQL 421
+ K + +G G++ P G V +Y + D T+F DR+ +G G++
Sbjct: 33 VLKVIKREGTGTEMPMIGDRVFVHYTGWL------LDGTKFDSSLDRKDKFSFDLGKGEV 86
Query: 422 LPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVIDFTEKNLIDD 598
+ D+A+ +M E H +G G PP+IP A + E+E+ +F ++L ++
Sbjct: 87 IKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEE 145
>sp|Q43207|FKB70_WHEAT 70 kDa peptidylprolyl isomerase (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rotamase)
Length = 559
Score = 58.9 bits (141), Expect = 2e-08
Identities = 35/128 (27%), Positives = 70/128 (54%), Gaps = 3/128 (2%)
Frame = +2
Query: 248 GQKLIFKRLISKGEGSKAPEGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQLLP 427
G++ + K+L+ +GEG PE + + + + FDS+R + + ++G GQ++
Sbjct: 39 GKQGLKKKLLKEGEGWDTPEVGDEVEVHYTGTLLDGKKFDSSRDRDDTFKFKLGQGQVIK 98
Query: 428 GLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVIDFTE-KNLIDD-- 598
G D +++M + E A F + +GE G PP IP A + ++E++ +T +++ D
Sbjct: 99 GWDQGIKTMKKGENALFTIPPELAYGESGSPPTIPANATLQFDVELLSWTSVRDIAKDGG 158
Query: 599 FFEKTVEE 622
F+K ++E
Sbjct: 159 IFKKILKE 166
Score = 51.2 bits (121), Expect = 4e-06
Identities = 54/238 (22%), Positives = 101/238 (42%), Gaps = 16/238 (6%)
Frame = +2
Query: 245 GGQKLIFKRLISKGEGSKAP-EGSLV------------IYNYKFYCEPEPEPFDSTRFKK 385
G K I K+++ + EG + P EG++V ++ K + E EP F+
Sbjct: 271 GDDKKILKKVLKEXEGYERPNEGAVVTVKITGKLQDGTVFLKKGHDEQEP-------FEF 323
Query: 386 RPDRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFG--ELGVPPRIPERADIYAEI 559
+ D + V + GLD A+ +M + E A +G E +P + + E+
Sbjct: 324 KTDEEAV-----IEGLDRAVLNMKKGEVALVTIPPEYAYGSTESKQDAIVPPNSTVIYEV 378
Query: 560 EVIDFTEKNLIDDFFEKTVEERLELSFSDMIKLVIQCRDDANVAVRDKRFGGALNKYQRG 739
E++ F + +E +L+ S+ I+ +++ N + ++ A +Y++
Sbjct: 379 ELVSFVKD-----------KESWDLNNSEKIEAAGTKKEEGNALFKSGKYARASKRYEKA 427
Query: 740 LDIL-YSMPICTDDEERIRSGHVTKLHLNMAHCNLKLNRGPSAIKCCNVVLGKQPHNV 910
+ Y D++++ + +T +LN A C LKL A K C VL NV
Sbjct: 428 AKFIEYDTSFSEDEKKQSKQLKIT-CNLNNAACKLKLKDYKQAEKLCTKVLELDSRNV 484
>sp|P27124|FKBP4_RABIT FK506-binding protein 4 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (p59 protein) (HSP binding
immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506
binding protein) (FKBP59)
Length = 458
Score = 58.5 bits (140), Expect = 2e-08
Identities = 59/230 (25%), Positives = 108/230 (46%), Gaps = 6/230 (2%)
Frame = +2
Query: 236 DISGGQKLIFKRLISKGEGSKAP-EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGV 412
D GG I +R+ ++GEG P +G++V + Y + F +R R VG
Sbjct: 145 DEDGG---IIRRIRTRGEGYARPNDGAIVEVALEGY-------YKDRLFDQRELRFEVGE 194
Query: 413 GQLLP---GLDVALQSMSRKERAHFVFDSSVMFGELGVPP-RIPERADIYAEIEVIDFTE 580
G+ L GL+ A+Q M + E + S FG G +IP A++ E+ + F +
Sbjct: 195 GESLDLPCGLEKAIQRMEKGEHSILYLKPSYAFGNAGKEKFQIPPYAELKYEVHLKSFEK 254
Query: 581 KNLIDDFFEKTVEERLELSFSDMIKLVIQCRDDANVAVRDKRFGGALNKYQRGLDIL-YS 757
+ +E + EE+LE S ++ V ++ ++ AL +Y++ + L Y
Sbjct: 255 AK---ESWEMSSEEKLEQSAI--------VKERGTVYFKEGKYKQALLQYKKIVSWLEYE 303
Query: 758 MPICTDDEERIRSGHVTKLHLNMAHCNLKLNRGPSAIKCCNVVLGKQPHN 907
+++ ++ ++ + HLN+A C+LKL +A++ CN L +N
Sbjct: 304 SSFSSEEVQKAQALRLAS-HLNLAMCHLKLQAFSAAVESCNKALELDSNN 352
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/119 (26%), Positives = 55/119 (46%), Gaps = 6/119 (5%)
Frame = +2
Query: 260 IFKRLISKGEGSKAPE-GSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQR-----VGVGQL 421
+ K + +G G++ P G V +Y + D T+F DR+ +G G++
Sbjct: 33 VLKVIKREGTGTETPMIGDRVFVHYTGWL------LDGTKFDSSLDRKDKFSFDLGKGEV 86
Query: 422 LPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVIDFTEKNLIDD 598
+ D+A+ +M E +G G PP+IP A + E+E+ +F ++L DD
Sbjct: 87 IKAWDIAVATMKVGELCRITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTDD 145
>sp|Q13451|FKBP5_HUMAN FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (51 kDa FK506-binding protein)
(FKBP-51) (54 kDa progesterone receptor-associated
immunophilin) (FKBP54) (P54) (FF1 antigen)
(HSP90-binding immunophilin) (Androgen-regulated protein
6)
Length = 457
Score = 54.7 bits (130), Expect = 4e-07
Identities = 34/129 (26%), Positives = 64/129 (49%), Gaps = 2/129 (1%)
Frame = +2
Query: 218 IASKMTDISGGQKLIFKRLISK-GEGSKAPE-GSLVIYNYKFYCEPEPEPFDSTRFKKRP 391
+A + DI+ + +++ + G G + P G V +YK + FDS+ + P
Sbjct: 18 VAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS-NGKKFDSSHDRNEP 76
Query: 392 DRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVID 571
+G GQ++ D+ + +M + E H + +G G P+IP A ++ EIE++D
Sbjct: 77 FVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLD 136
Query: 572 FTEKNLIDD 598
F ++L +D
Sbjct: 137 FKGEDLFED 145
Score = 50.1 bits (118), Expect = 9e-06
Identities = 52/221 (23%), Positives = 89/221 (40%), Gaps = 5/221 (2%)
Frame = +2
Query: 260 IFKRLISKGEGSKAP-EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQ---LLP 427
I +R KGEG P EG+ V + + C F R VG G+ +
Sbjct: 148 IIRRTKRKGEGYSNPNEGATVEIHLEGRC-------GGRMFDCRDVAFTVGEGEDHDIPI 200
Query: 428 GLDVALQSMSRKERAHFVFDSSVMFGELGVPP-RIPERADIYAEIEVIDFTEKNLIDDFF 604
G+D AL+ M R+E+ FGE G P I A++ E+ + F +
Sbjct: 201 GIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEK-------- 252
Query: 605 EKTVEERLELSFSDMIKLVIQCRDDANVAVRDKRFGGALNKYQRGLDILYSMPICTDDEE 784
+E E+ + ++ ++ V + ++ A+ +Y + + L ++ E
Sbjct: 253 ---AKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKES 309
Query: 785 RIRSGHVTKLHLNMAHCNLKLNRGPSAIKCCNVVLGKQPHN 907
+ + LN+A C LKL A++CC+ LG N
Sbjct: 310 KASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSAN 350
>sp|Q64378|FKBP5_MOUSE FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (51 kDa FK506-binding protein)
(FKBP-51)
Length = 456
Score = 54.7 bits (130), Expect = 4e-07
Identities = 31/106 (29%), Positives = 55/106 (51%), Gaps = 1/106 (0%)
Frame = +2
Query: 284 GEGSKAPE-GSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQLLPGLDVALQSMSR 460
G +AP G V +YK + + FDS+ +K+P +G GQ++ D+ + +M +
Sbjct: 41 GTSDEAPMFGDKVYVHYKGMLS-DGKKFDSSHDRKKPFAFSLGQGQVIKAWDIGVSTMKK 99
Query: 461 KERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVIDFTEKNLIDD 598
E H + +G G +IP A ++ EIE++DF ++L +D
Sbjct: 100 GEICHLLCKPEYAYGSAGHLQKIPSNATLFFEIELLDFKGEDLFED 145
Score = 48.1 bits (113), Expect = 3e-05
Identities = 51/221 (23%), Positives = 89/221 (40%), Gaps = 5/221 (2%)
Frame = +2
Query: 260 IFKRLISKGEGSKAP-EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQ---LLP 427
+ +R+ KGEG P EG+ V + + C F R VG G+ +
Sbjct: 148 VIRRIKRKGEGYSNPNEGATVKVHLEGCC-------GGRTFDCRDVVFVVGEGEDHDIPI 200
Query: 428 GLDVALQSMSRKERAHFVFDSSVMFGELGVPP-RIPERADIYAEIEVIDFTEKNLIDDFF 604
G+D AL M R+E+ FGE G P I A++ E+ + F +
Sbjct: 201 GIDKALVKMQREEQCILYLGPRYGFGEAGKPKFGIDPNAELMYEVTLKSFEK-------- 252
Query: 605 EKTVEERLELSFSDMIKLVIQCRDDANVAVRDKRFGGALNKYQRGLDILYSMPICTDDEE 784
+E E+ + + ++ V + ++ A+ +Y++ + L ++ E
Sbjct: 253 ---AKESWEMDTKEKLTQAAIVKEKGTVYFKGGKYTQAVIQYRKIVSWLEMEYGLSEKES 309
Query: 785 RIRSGHVTKLHLNMAHCNLKLNRGPSAIKCCNVVLGKQPHN 907
+ + LN+A C LKL A++CC+ LG N
Sbjct: 310 KASESFLLAAFLNLAMCYLKLREYNKAVECCDKALGLDSAN 350
>sp|Q5RF88|FKBP5_PONPY FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase)
Length = 457
Score = 54.7 bits (130), Expect = 4e-07
Identities = 34/129 (26%), Positives = 64/129 (49%), Gaps = 2/129 (1%)
Frame = +2
Query: 218 IASKMTDISGGQKLIFKRLISK-GEGSKAPE-GSLVIYNYKFYCEPEPEPFDSTRFKKRP 391
+A + DI+ + +++ + G G + P G V +YK + FDS+ + P
Sbjct: 18 VAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS-NGKKFDSSHDRNEP 76
Query: 392 DRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVID 571
+G GQ++ D+ + +M + E H + +G G P+IP A ++ EIE++D
Sbjct: 77 FVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLD 136
Query: 572 FTEKNLIDD 598
F ++L +D
Sbjct: 137 FKGEDLFED 145
Score = 48.9 bits (115), Expect = 2e-05
Identities = 52/221 (23%), Positives = 90/221 (40%), Gaps = 5/221 (2%)
Frame = +2
Query: 260 IFKRLISKGEGSKAP-EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQ--LLP- 427
I +R KGEG P EG+ V + + C F R VG G+ ++P
Sbjct: 148 IIRRTKRKGEGYSNPNEGATVEIHLEGRC-------GGRMFDCRDVAFTVGEGEDHVIPI 200
Query: 428 GLDVALQSMSRKERAHFVFDSSVMFGELGVPP-RIPERADIYAEIEVIDFTEKNLIDDFF 604
G+D AL+ M R+E+ FGE G P I A++ E+ + F +
Sbjct: 201 GIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEK-------- 252
Query: 605 EKTVEERLELSFSDMIKLVIQCRDDANVAVRDKRFGGALNKYQRGLDILYSMPICTDDEE 784
+E E+ + ++ ++ V + ++ A+ +Y + + L ++ E
Sbjct: 253 ---AKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKES 309
Query: 785 RIRSGHVTKLHLNMAHCNLKLNRGPSAIKCCNVVLGKQPHN 907
+ + LN+A C KL A++CC+ LG N
Sbjct: 310 KASESFLLAAFLNLAMCYSKLREYTKAVECCDKALGLDSAN 350
>sp|Q9XT11|FKBP5_AOTNA FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase) (51
kDa FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 54.3 bits (129), Expect = 5e-07
Identities = 31/108 (28%), Positives = 54/108 (50%), Gaps = 3/108 (2%)
Frame = +2
Query: 284 GEGSKAP---EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQLLPGLDVALQSM 454
G G + P + V YN K + FDS+ + P +G GQ++ D+ + +M
Sbjct: 41 GHGEETPMIGDKVYVHYNGKL---SNGKKFDSSHDRNEPFVFSIGKGQVIKAWDIGVATM 97
Query: 455 SRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVIDFTEKNLIDD 598
+ E H + +G G P+IP A ++ EIE++DF ++L++D
Sbjct: 98 KKGEICHLLCKPEYAYGATGSLPKIPSNATLFFEIELLDFKGEDLLED 145
Score = 45.8 bits (107), Expect = 2e-04
Identities = 50/221 (22%), Positives = 89/221 (40%), Gaps = 5/221 (2%)
Frame = +2
Query: 260 IFKRLISKGEGSKAP-EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQ---LLP 427
I +R +GEG P EG+ V + + C F R VG G+ +
Sbjct: 148 IIRRTKRRGEGYSNPNEGARVQIHLEGRC-------GGRVFDCRDVAFTVGEGEDHDIPI 200
Query: 428 GLDVALQSMSRKERAHFVFDSSVMFGELGVPP-RIPERADIYAEIEVIDFTEKNLIDDFF 604
G+D AL+ M R+E+ FGE G P I A++ E+ + F +
Sbjct: 201 GIDKALEKMQREEQCILHLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEK-------- 252
Query: 605 EKTVEERLELSFSDMIKLVIQCRDDANVAVRDKRFGGALNKYQRGLDILYSMPICTDDEE 784
+E E+ + ++ ++ + + ++ A+ +Y + + L ++ E
Sbjct: 253 ---AKESWEMDTKEKLEQAAIVKEKGTLYFKGGKYVQAVIQYGKIVSWLEMEYGLSEKES 309
Query: 785 RIRSGHVTKLHLNMAHCNLKLNRGPSAIKCCNVVLGKQPHN 907
+ + LN+A C LKL A++CC+ LG N
Sbjct: 310 KASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSAN 350
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,717,095
Number of Sequences: 369166
Number of extensions: 1859122
Number of successful extensions: 5159
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4908
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5138
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9270587090
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)