Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_H11
(650 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P26779|SAP_BOVIN Proactivator polypeptide precursor [Con... 76 9e-14
sp|P07602|SAP_HUMAN Proactivator polypeptide precursor [Con... 75 1e-13
sp|O13035|SAP_CHICK Proactivator polypeptide precursor [Con... 74 3e-13
sp|P10960|SAP_RAT Sulfated glycoprotein 1 precursor (SGP-1)... 64 3e-10
sp|P20097|SAP_CAVPO Saposin C (CO-beta-glucosidase) (Glucos... 59 1e-08
sp|Q61207|SAP_MOUSE Sulfated glycoprotein 1 precursor (SGP-... 59 1e-08
sp|P50405|PSPB_MOUSE Pulmonary surfactant-associated protei... 48 3e-05
sp|P42211|ASPRX_ORYSA Aspartic proteinase precursor 47 6e-05
sp|Q24824|PFPB_ENTHI Pore-forming peptide ameobapore B prec... 45 2e-04
sp|P22355|PSPB_RAT Pulmonary surfactant-associated protein ... 44 3e-04
>sp|P26779|SAP_BOVIN Proactivator polypeptide precursor [Contains: Saposin A (Protein
A); Saposin B (Sphingolipid activator protein 1) (SAP-1)
(Cerebroside sulfate activator) (CSAct) (Dispersin)
(Sulfatide/GM1 activator); Saposin C
(Co-beta-glucosidase) (A1 activator) (Glucosylceramidase
activator) (Sphingolipid activator protein 2) (SAP-2);
Saposin D (Protein C) (Component C)]
Length = 525
Score = 75.9 bits (185), Expect = 9e-14
Identities = 43/180 (23%), Positives = 87/180 (48%), Gaps = 29/180 (16%)
Frame = +3
Query: 198 CDICKQVIQGVLNAIGGDHS-KEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMIM 374
C C Q++ V A+ + + EA+ + C+ LGP CK ++++++++ + M+M
Sbjct: 199 CQDCIQLVTDVQEALRTNSTFVEALVDHAKEECDRLGPGMSDMCKNYINQYSEVAIQMVM 258
Query: 375 KNLSPDQICRNIGLC-----------------SSNVVEQLQKIKSIQ-----------CM 470
++ P +IC G C S NV+ L ++ I+ C
Sbjct: 259 -HMQPKEICVLAGFCDEVKEMPMKTLVPAEVVSENVIPALGLVEPIKKDPAPAKADIYCE 317
Query: 471 ICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVPMRGDCKNFMNRFSNEIVKLIMNNA 650
+C+ ++KE+ +LI N RTE+ I AL +C+ P + C+ ++ + I+ ++++ A
Sbjct: 318 VCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGRSILSILLDEA 377
Score = 74.7 bits (182), Expect = 2e-13
Identities = 36/155 (23%), Positives = 78/155 (50%), Gaps = 5/155 (3%)
Frame = +3
Query: 192 VQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMI 371
+ C++C+ V++ V I + ++E I A + VC+ L +C+E VD + ++ ++
Sbjct: 314 IYCEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGRSILSIL 373
Query: 372 MKNLSPDQICRNIGLCSSN-----VVEQLQKIKSIQCMICKEIIKEIFRLIGNKRTEDVI 536
+ SP+ +C + LCSS V + + C +CK+++ + R + T++ I
Sbjct: 374 LDEASPELVCSMLHLCSSRGLPAATVRVMPRKDGGFCEVCKKLVGYLDRNLEKNSTKEQI 433
Query: 537 RQALQGICNIFPVPMRGDCKNFMNRFSNEIVKLIM 641
AL+ C+ P R C F+ + ++++++
Sbjct: 434 LAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILV 468
Score = 57.0 bits (136), Expect = 4e-08
Identities = 48/203 (23%), Positives = 84/203 (41%), Gaps = 48/203 (23%)
Frame = +3
Query: 180 TSKSVQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDL-GPFWKTECKEFVDRFADI 356
T KS+ CDICK VI N + + +++ I E C+ L P CKE VD + +
Sbjct: 57 TVKSLPCDICKDVITAAGNLLKDNATEQEILMYLERTCDWLPKPNMSASCKEIVDSYLPV 116
Query: 357 LVDMIMKNLS-PDQICRNIGLCSS--------NVVEQLQ--------------------- 446
++DMI +S P ++C + LC S N +QL+
Sbjct: 117 ILDMIKGQMSHPGEVCSALNLCESLQKHLAELNHQKQLESNQIPELDMAEVVAPFMANIP 176
Query: 447 -------------KIKSIQCMICKEIIKEIFRLIGNKRTEDVIRQAL----QGICNIFPV 575
+ K +C++ I+ + + RT +AL + C+
Sbjct: 177 FLLYPQDGSHSKPQPKKANGNVCQDCIQLVTDVQEALRTNSTFVEALVDHAKEECDRLGP 236
Query: 576 PMRGDCKNFMNRFSNEIVKLIMN 644
M CKN++N++S ++++M+
Sbjct: 237 GMSDMCKNYINQYSEVAIQMVMH 259
Score = 49.3 bits (116), Expect = 9e-06
Identities = 19/74 (25%), Positives = 43/74 (58%)
Frame = +3
Query: 198 CDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMIMK 377
C++CK+++ + + + +KE I A E C+ L ++ +C +FV + +L++++++
Sbjct: 410 CEVCKKLVGYLDRNLEKNSTKEQILAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVE 469
Query: 378 NLSPDQICRNIGLC 419
+ P +C IG C
Sbjct: 470 VMDPSFVCLKIGAC 483
>sp|P07602|SAP_HUMAN Proactivator polypeptide precursor [Contains: Saposin A (Protein
A); Saposin B-Val; Saposin B (Sphingolipid activator
protein 1) (SAP-1) (Cerebroside sulfate activator)
(CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C
(Co-beta-glucosidase) (A1 activator) (Glucosylceramidase
activator) (Sphingolipid activator protein 2) (SAP-2);
Saposin D (Protein C) (Component C)]
Length = 524
Score = 75.5 bits (184), Expect = 1e-13
Identities = 36/155 (23%), Positives = 79/155 (50%), Gaps = 5/155 (3%)
Frame = +3
Query: 192 VQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMI 371
V C++C+ +++ V I + +++ I AF+ +C+ L EC+E VD + ++ ++
Sbjct: 313 VYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSIL 372
Query: 372 MKNLSPDQICRNIGLCSSN-----VVEQLQKIKSIQCMICKEIIKEIFRLIGNKRTEDVI 536
++ +SP+ +C + LCS V Q C +CK+++ + R + T+ I
Sbjct: 373 LEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEI 432
Query: 537 RQALQGICNIFPVPMRGDCKNFMNRFSNEIVKLIM 641
AL+ C+ P P + C F+ + ++++++
Sbjct: 433 LAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILV 467
Score = 71.6 bits (174), Expect = 2e-12
Identities = 39/177 (22%), Positives = 87/177 (49%), Gaps = 29/177 (16%)
Frame = +3
Query: 198 CDICKQVIQGVLNAIGGDHS-KEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMIM 374
C C Q++ + A+ + + +A+ + + C+ LGP CK ++ ++++I + M+M
Sbjct: 198 CQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMM 257
Query: 375 KNLSPDQICRNIGLC-----------------SSNVVEQLQKIKSIQ-----------CM 470
++ P +IC +G C S NV+ L+ ++ I+ C
Sbjct: 258 -HMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCE 316
Query: 471 ICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVPMRGDCKNFMNRFSNEIVKLIM 641
+C+ ++KE+ +LI N +TE I A +C+ P + +C+ ++ + + I+ +++
Sbjct: 317 VCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILL 373
Score = 53.1 bits (126), Expect = 6e-07
Identities = 28/84 (33%), Positives = 45/84 (53%), Gaps = 2/84 (2%)
Frame = +3
Query: 180 TSKSVQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDL-GPFWKTECKEFVDRFADI 356
T KS+ CDICK V+ + + + ++E I E C+ L P CKE VD + +
Sbjct: 57 TVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPV 116
Query: 357 LVDMIMKNLS-PDQICRNIGLCSS 425
++D+I +S P ++C + LC S
Sbjct: 117 ILDIIKGEMSRPGEVCSALNLCES 140
Score = 48.1 bits (113), Expect = 2e-05
Identities = 19/76 (25%), Positives = 44/76 (57%)
Frame = +3
Query: 198 CDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMIMK 377
C++CK+++ + + + +K+ I A E C+ L ++ +C +FV + +L++++++
Sbjct: 409 CEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVE 468
Query: 378 NLSPDQICRNIGLCSS 425
+ P +C IG C S
Sbjct: 469 VMDPSFVCLKIGACPS 484
Score = 36.6 bits (83), Expect = 0.058
Identities = 18/64 (28%), Positives = 34/64 (53%), Gaps = 1/64 (1%)
Frame = +3
Query: 450 IKSIQCMICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVP-MRGDCKNFMNRFSNEI 626
+KS+ C ICK+++ ++ + TE+ I L+ C+ P P M CK ++ + I
Sbjct: 58 VKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVI 117
Query: 627 VKLI 638
+ +I
Sbjct: 118 LDII 121
>sp|O13035|SAP_CHICK Proactivator polypeptide precursor [Contains: Saposin A; Saposin B;
Saposin C; Saposin D]
Length = 518
Score = 73.9 bits (180), Expect = 3e-13
Identities = 43/188 (22%), Positives = 88/188 (46%), Gaps = 10/188 (5%)
Frame = +3
Query: 105 CVDFKRNEFQNNIKIKVHADIEISTTSKSVQ-------CDICKQVIQGVLNAIGGDHSKE 263
C K Q + +V ++++ T K+ C+IC+ +++ V + + ++E
Sbjct: 273 CPSVKSVPLQTLVPAQVVHEVKMETVEKATVQEKTFSVCEICETMVKEVTGLLESNKTEE 332
Query: 264 AIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMIMKNLSPDQICRNIGLCSSNVVEQ- 440
I E VC L K +CK+F++ + L+DM+++ +P+ +C + C++N Q
Sbjct: 333 EIVHEMEVVCYLLPASVKDQCKDFIEVYGQALIDMLLEATNPEAVCVMLKCCAANKPPQQ 392
Query: 441 --LQKIKSIQCMICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVPMRGDCKNFMNRF 614
+ K C ICK I+ + + T I L+ +C+ P + C F+ ++
Sbjct: 393 PVVVKPAGGFCDICKMIVAYADKELEKNATTTEIEALLEKVCHFLPESVSDQCVQFVEQY 452
Query: 615 SNEIVKLI 638
+V+L+
Sbjct: 453 EPVVVQLL 460
Score = 71.2 bits (173), Expect = 2e-12
Identities = 44/199 (22%), Positives = 91/199 (45%), Gaps = 28/199 (14%)
Frame = +3
Query: 129 FQNNIKIKVHADIEISTTSKSVQ--CDICKQVIQGVLNAIGGDHS--KEAIRKAFENVCN 296
F N+ + ++ + SK+ + C C +++ V A+ + + K + A E C+
Sbjct: 172 FMANVPLLLYPQDKPKQKSKATEDVCQDCIRLVTDVQEAVRTNATFVKSLVAHAKEE-CD 230
Query: 297 DLGPFWKTECKEFVDRFADILVDMIM--KNLSPDQICRNIGLCSSNVVEQLQKIKSIQ-- 464
LGP CK ++ ++D+ + M+M K+ P IC +G C S LQ + Q
Sbjct: 231 RLGPGMSDMCKSYISEYSDLAIQMMMHMKDQQPKDICAMVGFCPSVKSVPLQTLVPAQVV 290
Query: 465 --------------------CMICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVPMR 584
C IC+ ++KE+ L+ + +TE+ I ++ +C + P ++
Sbjct: 291 HEVKMETVEKATVQEKTFSVCEICETMVKEVTGLLESNKTEEEIVHEMEVVCYLLPASVK 350
Query: 585 GDCKNFMNRFSNEIVKLIM 641
CK+F+ + ++ +++
Sbjct: 351 DQCKDFIEVYGQALIDMLL 369
Score = 50.1 bits (118), Expect = 5e-06
Identities = 25/81 (30%), Positives = 44/81 (54%), Gaps = 2/81 (2%)
Frame = +3
Query: 189 SVQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDL-GPFWKTECKEFVDRFADILVD 365
S+ CD+CK+++ V + + +++ IR E C L +ECKE VD + +++D
Sbjct: 61 SIPCDLCKELVTVVGKVLKDNGTEDEIRSYLEKRCEFLPDQGLASECKEIVDSYLPVIMD 120
Query: 366 MIMKNL-SPDQICRNIGLCSS 425
MI + P+ +C + LC S
Sbjct: 121 MIKEEFDKPEVVCSALSLCQS 141
Score = 49.7 bits (117), Expect = 7e-06
Identities = 30/142 (21%), Positives = 62/142 (43%), Gaps = 19/142 (13%)
Frame = +3
Query: 57 EIKFLCTFFPEILKEKCVDFKRNEFQNNIKIKVHAD--------IEISTTSKSVQ----- 197
E++ +C P +K++C DF Q I + + A ++ +K Q
Sbjct: 337 EMEVVCYLLPASVKDQCKDFIEVYGQALIDMLLEATNPEAVCVMLKCCAANKPPQQPVVV 396
Query: 198 ------CDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFWKTECKEFVDRFADIL 359
CDICK ++ + + + I E VC+ L +C +FV+++ ++
Sbjct: 397 KPAGGFCDICKMIVAYADKELEKNATTTEIEALLEKVCHFLPESVSDQCVQFVEQYEPVV 456
Query: 360 VDMIMKNLSPDQICRNIGLCSS 425
V ++ + + P +C +G+C +
Sbjct: 457 VQLLAEMMDPTFVCTKLGVCGA 478
Score = 40.8 bits (94), Expect = 0.003
Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 1/81 (1%)
Frame = +3
Query: 399 CRNIGLCSSNVVEQLQKIKSIQCMICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFP-V 575
C + C NV + + SI C +CKE++ + +++ + TED IR L+ C P
Sbjct: 43 CGAVKHCQQNVWSK-PAVNSIPCDLCKELVTVVGKVLKDNGTEDEIRSYLEKRCEFLPDQ 101
Query: 576 PMRGDCKNFMNRFSNEIVKLI 638
+ +CK ++ + I+ +I
Sbjct: 102 GLASECKEIVDSYLPVIMDMI 122
>sp|P10960|SAP_RAT Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin)
Length = 554
Score = 63.9 bits (154), Expect = 3e-10
Identities = 38/178 (21%), Positives = 82/178 (46%), Gaps = 29/178 (16%)
Frame = +3
Query: 198 CDICKQVIQGVLNAIGGDHS-KEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMIM 374
C C +++ + A+ + S + + + C+ LGP CK +VD+++++ V M+M
Sbjct: 197 CQDCMKLVTDIQTAVRTNSSFVQGLVDHVKEDCDRLGPGVSDICKNYVDQYSEVAVQMMM 256
Query: 375 KNLSPDQICRNIGLCSS-------NVVEQLQKIKSIQ---------------------CM 470
++ P +IC +G C +V + IK+I C
Sbjct: 257 -HMQPKEICVMVGFCDEVKRVPMRTLVPATEAIKNILPALELTDPYEQDVIQAQNVIFCQ 315
Query: 471 ICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVPMRGDCKNFMNRFSNEIVKLIMN 644
+C+ +++++ LI N TE+++ + L C++ P P C+ + F ++ ++M+
Sbjct: 316 VCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMH 373
Score = 54.3 bits (129), Expect = 3e-07
Identities = 37/184 (20%), Positives = 79/184 (42%), Gaps = 36/184 (19%)
Frame = +3
Query: 198 CDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMIMK 377
C +C+ V++ + I + ++E + K C+ L T+C+E + F L+D++M
Sbjct: 314 CQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMH 373
Query: 378 NLSPDQICRNIGLCSSN-------------VVEQLQKIKSIQ------------------ 464
++P+ +C I LCS+N +V L K +
Sbjct: 374 EVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQ 433
Query: 465 -----CMICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVPMRGDCKNFMNRFSNEIV 629
C +CK+++ + + T++ I AL+ C+ P P + C F+ + ++
Sbjct: 434 KNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLL 493
Query: 630 KLIM 641
++++
Sbjct: 494 EILV 497
Score = 52.0 bits (123), Expect = 1e-06
Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 2/84 (2%)
Frame = +3
Query: 180 TSKSVQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDL-GPFWKTECKEFVDRFADI 356
T+KS+ CDICK V+ N + + ++E I E C + CKE VD + +
Sbjct: 57 TAKSLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDSSLSASCKEVVDSYLPV 116
Query: 357 LVDMIMKNLS-PDQICRNIGLCSS 425
++DMI +S P ++C + LC S
Sbjct: 117 ILDMIKGEMSNPGEVCSALNLCQS 140
Score = 50.8 bits (120), Expect = 3e-06
Identities = 21/76 (27%), Positives = 46/76 (60%)
Frame = +3
Query: 198 CDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMIMK 377
C++CK+++ + + + + +KE I A E C+ L ++ +C EFV + +L++++++
Sbjct: 439 CEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVE 498
Query: 378 NLSPDQICRNIGLCSS 425
+ P +C IG+C S
Sbjct: 499 VMDPSFVCSKIGVCPS 514
Score = 33.9 bits (76), Expect = 0.38
Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 1/81 (1%)
Frame = +3
Query: 399 CRNIGLCSSNVVEQLQKIKSIQCMICKEIIKEIFRLIGNKRTEDVIRQALQGICN-IFPV 575
CR + C V + KS+ C ICK ++ E L+ + TE+ I L+ C I
Sbjct: 42 CRAVKHCQQMVWSK-PTAKSLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDS 100
Query: 576 PMRGDCKNFMNRFSNEIVKLI 638
+ CK ++ + I+ +I
Sbjct: 101 SLSASCKEVVDSYLPVILDMI 121
>sp|P20097|SAP_CAVPO Saposin C (CO-beta-glucosidase) (Glucosylceramidase activator)
(Sphingolipid activator protein 2) (SAP-2)
Length = 81
Score = 58.9 bits (141), Expect = 1e-08
Identities = 26/80 (32%), Positives = 47/80 (58%)
Frame = +3
Query: 186 KSVQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVD 365
+SV C C+ V++ V+ I + ++E I A ++VC L C+E VD + D +V
Sbjct: 1 ESVTCKACEYVVKKVMELIDNNRTEEKIIHALDSVCALLPESVSEVCQEVVDTYGDSIVA 60
Query: 366 MIMKNLSPDQICRNIGLCSS 425
++++ +SP+ +C +GLC S
Sbjct: 61 LLLQEMSPELVCSELGLCMS 80
Score = 48.5 bits (114), Expect = 1e-05
Identities = 19/63 (30%), Positives = 37/63 (58%)
Frame = +3
Query: 453 KSIQCMICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVPMRGDCKNFMNRFSNEIVK 632
+S+ C C+ ++K++ LI N RTE+ I AL +C + P + C+ ++ + + IV
Sbjct: 1 ESVTCKACEYVVKKVMELIDNNRTEEKIIHALDSVCALLPESVSEVCQEVVDTYGDSIVA 60
Query: 633 LIM 641
L++
Sbjct: 61 LLL 63
>sp|Q61207|SAP_MOUSE Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin)
Length = 557
Score = 58.5 bits (140), Expect = 1e-08
Identities = 57/265 (21%), Positives = 106/265 (40%), Gaps = 51/265 (19%)
Frame = +3
Query: 3 SLIQVYITLGKEIQGSPGEIKF---LCTFFPEILKEKC-----------VDFKR--NEFQ 134
S + V + + K +PGE+ LC E L E+ VD R F
Sbjct: 112 SYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQKQLESNKIPEVDMARVVAPFM 171
Query: 135 NNIKIKV----HADIEISTTSKSVQCDICKQVIQGVLNAIGGDHSK-EAIRKAFENVCND 299
+NI + + H + + C C +++ V A+ + S + + C+
Sbjct: 172 SNIPLLLYPQDHPRSQPQPKANEDVCQDCMKLVSDVQTAVKTNSSFIQGFVDHVKEDCDR 231
Query: 300 LGPFWKTECKEFVDRFADILVDMI--MKNLSPDQICRNIGLCS-------SNVVEQLQKI 452
LGP CK +VD+++++ V M+ M++ P +IC G C+ +V + I
Sbjct: 232 LGPGVSDICKNYVDQYSEVCVQMLMHMQDQQPKEICVLAGFCNEVKRVPMKTLVPATETI 291
Query: 453 KS---------------------IQCMICKEIIKEIFRLIGNKRTEDVIRQALQGICNIF 569
K+ I C C+ ++ + LI N TE+++ + L C +
Sbjct: 292 KNILPALEMMDPYEQNLVQAHNVILCQTCQFVMNKFSELIVNNATEELLVKGLSNACALL 351
Query: 570 PVPMRGDCKNFMNRFSNEIVKLIMN 644
P P R C+ + F ++ + ++
Sbjct: 352 PDPARTKCQEVVGTFGPSLLDIFIH 376
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/186 (19%), Positives = 81/186 (43%), Gaps = 36/186 (19%)
Frame = +3
Query: 192 VQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMI 371
+ C C+ V+ I + ++E + K N C L +T+C+E V F L+D+
Sbjct: 315 ILCQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIF 374
Query: 372 MKNLSPDQICRNIGLCSS--NVVEQLQK-----IKSIQ---------------------- 464
+ ++P +C IGLC++ +VE L++ + ++
Sbjct: 375 IHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALPAHVP 434
Query: 465 -------CMICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVPMRGDCKNFMNRFSNE 623
C +CK+++ + + T++ I AL+ C+ P P + C +F+ +
Sbjct: 435 PQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPL 494
Query: 624 IVKLIM 641
++++++
Sbjct: 495 LLEILV 500
Score = 53.5 bits (127), Expect = 5e-07
Identities = 32/95 (33%), Positives = 49/95 (51%), Gaps = 5/95 (5%)
Frame = +3
Query: 180 TSKSVQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDL-GPFWKTECKEFVDRFADI 356
T+KS+ CDICK V+ N + + ++E I E C + CKE VD + +
Sbjct: 57 TAKSLPCDICKTVVTEAGNLLKDNATQEEILHYLEKTCEWIHDSSLSASCKEVVDSYLPV 116
Query: 357 LVDMIMKNLS-PDQICRNIGLCSS---NVVEQLQK 449
++DMI +S P ++C + LC S + EQ QK
Sbjct: 117 ILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQK 151
Score = 49.7 bits (117), Expect = 7e-06
Identities = 20/76 (26%), Positives = 46/76 (60%)
Frame = +3
Query: 198 CDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFWKTECKEFVDRFADILVDMIMK 377
C++CK+++ + + + + +KE I A E C+ L ++ +C +FV + +L++++++
Sbjct: 442 CEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVE 501
Query: 378 NLSPDQICRNIGLCSS 425
+ P +C IG+C S
Sbjct: 502 VMDPGFVCSKIGVCPS 517
>sp|P50405|PSPB_MOUSE Pulmonary surfactant-associated protein B precursor (SP-B)
(Pulmonary surfactant-associated proteolipid SPL(Phe))
Length = 377
Score = 47.8 bits (112), Expect = 3e-05
Identities = 35/182 (19%), Positives = 70/182 (38%), Gaps = 42/182 (23%)
Frame = +3
Query: 198 CDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLG-PFWKTECKEFVDRFADILVDMIM 374
C C+ ++ + D +EAIRK E C+ L C++ +D + +++D
Sbjct: 68 CQECEDIVHLLTKMTKEDAFQEAIRKFLEQECDILPLKLLVPRCRQVLDVYLPLVIDYFQ 127
Query: 375 KNLSPDQICRNIGLC-----------------------------------------SSNV 431
++P IC ++GLC + +
Sbjct: 128 SQINPKAICNHVGLCPRGQAKPEQNPGMPDAVPNPLLDKLVLPVLPGALLARPGPHTQDF 187
Query: 432 VEQLQKIKSIQCMICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVPMRGDCKNFMNR 611
EQ I C +C+ +IK + +I + V+ A+ +C++ P+ + G C+ R
Sbjct: 188 SEQQLPIPLPFCWLCRTLIKRVQAVI----PKGVLAVAVSQVCHVVPLVVGGICQCLAER 243
Query: 612 FS 617
++
Sbjct: 244 YT 245
Score = 34.3 bits (77), Expect = 0.29
Identities = 19/82 (23%), Positives = 40/82 (48%), Gaps = 2/82 (2%)
Frame = +3
Query: 186 KSVQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFW--KTECKEFVDRFADIL 359
+ +C CK VI N S++A+ +A C FW + +C++FV++ L
Sbjct: 291 QDTECHFCKSVINQAWNT-----SEQAMPQAMHQACLR---FWLDRQKCEQFVEQHMPQL 342
Query: 360 VDMIMKNLSPDQICRNIGLCSS 425
+ ++ ++ C+ +G+C +
Sbjct: 343 LALVPRSQDAHITCQALGVCEA 364
>sp|P42211|ASPRX_ORYSA Aspartic proteinase precursor
Length = 496
Score = 46.6 bits (109), Expect = 6e-05
Identities = 22/98 (22%), Positives = 48/98 (48%), Gaps = 11/98 (11%)
Frame = +3
Query: 318 TECKEFVDRFADILVDMIMKNLSPDQICRNIGLCS-------SNVVEQLQKIKSI----Q 464
TECKE V + ++++++++ P ++C +GLC SN +E + +++
Sbjct: 310 TECKEVVSEYGEMILNLLIAQTDPQKVCSQVGLCMFDGKRSVSNGIESVVDKENLGSDAM 369
Query: 465 CMICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVP 578
C +C+ + I + +T+++I +C P P
Sbjct: 370 CSVCEMAVVWIENQLRENKTKELILNYANQLCERLPSP 407
>sp|Q24824|PFPB_ENTHI Pore-forming peptide ameobapore B precursor (EH-APP)
Length = 96
Score = 44.7 bits (104), Expect = 2e-04
Identities = 22/82 (26%), Positives = 43/82 (52%)
Frame = +3
Query: 174 STTSKSVQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFWKTECKEFVDRFAD 353
+T ++ C++CK ++ V N + D + +A+R+ +N+C F T C++ + D
Sbjct: 16 ATREGAILCNLCKDTVKLVENLLTVDGA-QAVRQYIDNLCGKASGFLGTLCEKILSFGVD 74
Query: 354 ILVDMIMKNLSPDQICRNIGLC 419
LV +I ++ P +C I C
Sbjct: 75 ELVKLIENHVDPVVVCEKIHAC 96
>sp|P22355|PSPB_RAT Pulmonary surfactant-associated protein B precursor (SP-B)
(Pulmonary surfactant-associated proteolipid SPL(Phe))
Length = 376
Score = 44.3 bits (103), Expect = 3e-04
Identities = 32/182 (17%), Positives = 68/182 (37%), Gaps = 42/182 (23%)
Frame = +3
Query: 198 CDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLG-PFWKTECKEFVDRFADILVDMIM 374
C C+ ++ + D ++ IRK E C+ L C++ +D + +++D
Sbjct: 67 CQECEDIVHLLTKMTKEDAFQDTIRKFLEQECDILPLKLLVPRCRQVLDVYLPLVIDYFQ 126
Query: 375 KNLSPDQICRNIGLCSSNVVEQLQKIKSIQ------------------------------ 464
+ P IC ++GLC + QK + +
Sbjct: 127 GQIKPKAICSHVGLCPLGQTKPEQKPEMLDAIPNPLLNKLVLPALPGAFLARPGPHTQDL 186
Query: 465 -----------CMICKEIIKEIFRLIGNKRTEDVIRQALQGICNIFPVPMRGDCKNFMNR 611
C +C+ +IK + +I + V+ A+ +C++ P+ + G C+ R
Sbjct: 187 SEQQLPIPLPFCWLCRTLIKRVQAVI----PKGVLAVAVSQVCHVVPLVVGGICQCLAER 242
Query: 612 FS 617
++
Sbjct: 243 YT 244
Score = 34.7 bits (78), Expect = 0.22
Identities = 19/82 (23%), Positives = 40/82 (48%), Gaps = 2/82 (2%)
Frame = +3
Query: 186 KSVQCDICKQVIQGVLNAIGGDHSKEAIRKAFENVCNDLGPFW--KTECKEFVDRFADIL 359
+ +C CK VI N S++A+ +A C FW + +C++FV++ L
Sbjct: 290 QDTECHFCKSVINQAWNT-----SEQAMPQAMHQACLR---FWLDRQKCEQFVEQHMPQL 341
Query: 360 VDMIMKNLSPDQICRNIGLCSS 425
+ ++ ++ C+ +G+C +
Sbjct: 342 LALVPRSQDAHTSCQALGVCEA 363
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,438,162
Number of Sequences: 369166
Number of extensions: 1412036
Number of successful extensions: 4189
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4012
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4161
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5365037700
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)