Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_G04
(855 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor... 133 5e-31
sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor... 132 1e-30
sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (... 131 3e-30
sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor... 129 8e-30
sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor... 127 5e-29
sp|Q9R0S2|MMP24_MOUSE Matrix metalloproteinase-24 precursor... 126 7e-29
sp|Q99PW6|MMP24_RAT Matrix metalloproteinase-24 precursor (... 126 7e-29
sp|P09237|MMP7_HUMAN Matrilysin precursor (Pump-1 protease)... 126 9e-29
sp|Q9Y5R2|MMP24_HUMAN Matrix metalloproteinase-24 precursor... 124 3e-28
sp|Q9NPA2|MMP25_HUMAN Matrix metalloproteinase-25 precursor... 124 3e-28
>sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 481
Score = 133 bits (335), Expect = 5e-31
Identities = 85/224 (37%), Positives = 120/224 (53%), Gaps = 4/224 (1%)
Frame = +2
Query: 125 VKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKGT-TYRFYIH 301
+K +Q+ GL GK+++ + + + RCG DV N R KW K T TYR
Sbjct: 70 IKELQEFFGLRVTGKLDRATMDVIKRPRCGVPDVA--NYRLFPGEPKWKKNTLTYRI--- 124
Query: 302 DERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNN 481
++ +MT E+ RA+ + L WS+A + F +++ + + +SF +H
Sbjct: 125 -SKYTPSMTPAEVDRAMEMALRAWSSAVPLNFVRINAGEADIM-ISFETGDH-------- 174
Query: 482 FVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLVAAHEMGH 652
D YP D P G LAHAF P G + HFD+AE+WT G +G NL VAAHE GH
Sbjct: 175 ----GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTVAAHEFGH 228
Query: 653 AIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTK 784
A+GL HS DP+ALM P Y Y + F+LP DD +G +YG +
Sbjct: 229 ALGLAHSTDPSALMFPTY-KYQNPYGFRLPKDDVKGIQALYGPR 271
>sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 132 bits (332), Expect = 1e-30
Identities = 87/230 (37%), Positives = 124/230 (53%), Gaps = 4/230 (1%)
Frame = +2
Query: 125 VKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKGT-TYRFYIH 301
+K +Q GL GK+++ + + K RCG DV N R KW K T TYR
Sbjct: 72 IKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVA--NYRLFPGEPKWKKNTLTYRI--- 126
Query: 302 DERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNN 481
++ +M+ E+ +A+ + L WS+A + F ++++ + + +SF + +H
Sbjct: 127 -SKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIM-ISFENGDH-------- 176
Query: 482 FVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLVAAHEMGH 652
D YP D P G LAHAF P G + HFD+AE+WT G +G NL VAAHE GH
Sbjct: 177 ----GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTVAAHEFGH 230
Query: 653 AIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFV 802
A+GL HS DP+ALM P Y Y + F LP DD +G +YG + KVF+
Sbjct: 231 ALGLAHSTDPSALMYPTY-KYKNPYGFHLPKDDVKGIQALYGPR--KVFL 277
>sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 131 bits (329), Expect = 3e-30
Identities = 85/224 (37%), Positives = 118/224 (52%), Gaps = 4/224 (1%)
Frame = +2
Query: 125 VKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKGT-TYRFYIH 301
+K +Q GL GK+++ + + + RCG DV N R KW K T TYR
Sbjct: 72 IKELQAFFGLRVTGKLDRTTMDVIKRPRCGVPDVA--NYRLFPGEPKWKKNTLTYRI--- 126
Query: 302 DERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNN 481
++ +MT E+ +A+ + L WS+A + F +V+ + + +SF +H
Sbjct: 127 -SKYTPSMTPAEVDKAMEMALQAWSSAVPLSFVRVNAGEADIM-ISFETGDH-------- 176
Query: 482 FVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLVAAHEMGH 652
D YP D P G LAHAF P G + HFD+AE+WT G +G NL VAAHE GH
Sbjct: 177 ----GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGM-NGFNLFTVAAHEFGH 230
Query: 653 AIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTK 784
A+GL HS DP+ALM P Y Y + F LP DD +G +YG +
Sbjct: 231 ALGLAHSTDPSALMYPTY-KYQNPYGFHLPKDDVKGIQALYGPR 273
>sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 482
Score = 129 bits (325), Expect = 8e-30
Identities = 86/229 (37%), Positives = 121/229 (52%), Gaps = 4/229 (1%)
Frame = +2
Query: 125 VKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKGT-TYRFYIH 301
+K +Q GL GK+++ + + K RCG DV N R KW K TYR
Sbjct: 71 IKELQIFFGLKVTGKLDQNTMNVIKKPRCGVPDVA--NYRLFPGEPKWKKNILTYRI--- 125
Query: 302 DERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNN 481
++ +M+ E+ +A+ + L WSTA + F ++++ + + +SF +H
Sbjct: 126 -SKYTPSMSPTEVDKAIQMALHAWSTAVPLNFVRINSGEADIM-ISFETGDH-------- 175
Query: 482 FVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLVAAHEMGH 652
D YP D P G LAHAF P G + HFD+AE+WT G +G NL VAAHE GH
Sbjct: 176 ----GDSYPFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTVAAHEFGH 229
Query: 653 AIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVF 799
A+GL HS DP+ALM P Y Y + F LP DD +G +YG + K+F
Sbjct: 230 ALGLGHSTDPSALMYPTY-KYQNPYRFHLPKDDVKGIQALYGPR--KIF 275
>sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor (MMP-19) (Matrix
metalloproteinase RASI)
Length = 527
Score = 127 bits (318), Expect = 5e-29
Identities = 83/244 (34%), Positives = 126/244 (51%), Gaps = 1/244 (0%)
Frame = +2
Query: 59 YVEKFLSDFYDYNENTDRLNDAVKNIQKMAGLPTDGKINKELLAHVGKSRCGGKD-VKPK 235
Y++K L D+ + + +A++ Q+ +GLP G+++ A + + RCG +D K
Sbjct: 38 YLQKPLEGADDFR--LEDITEALRTFQEASGLPISGQMDDATRARMKQPRCGLEDPFNQK 95
Query: 236 NKRYNAANSKWDKGTTYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNK 415
+ +Y K T+R + P+T++L ++ AL YWS+ + F +V
Sbjct: 96 SLKYLLLGHWRKKNLTFRIF----NVPSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAG 151
Query: 416 QGSMFSLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNGNLHFDSAEEWT 595
+ LSF + + N F + PG VLAHA P G++HFD E WT
Sbjct: 152 WADI-RLSFHGRQSLYCS--NTF----------DGPGKVLAHADIPELGSIHFDKDELWT 198
Query: 596 EGKEDGINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIY 775
EG G+NLR++AAHE+GHA+GL HS ALMAP Y GY + FKL DD G +Y
Sbjct: 199 EGTYQGVNLRIIAAHEVGHALGLGHSRYTQALMAPVYAGY--QPFFKLHPDDVAGIQALY 256
Query: 776 GTKN 787
G ++
Sbjct: 257 GKRS 260
>sp|Q9R0S2|MMP24_MOUSE Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP) (MMP-21)
Length = 618
Score = 126 bits (317), Expect = 7e-29
Identities = 88/241 (36%), Positives = 121/241 (50%), Gaps = 19/241 (7%)
Frame = +2
Query: 113 LNDAVKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDV-----KPKNKRYNAANSKW-DK 274
L AV +Q+ G+P G +++ + + K RCG D + +NKRY KW K
Sbjct: 80 LQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQK 139
Query: 275 GTTYRFYIHDERHPTTMTLGEI--QRALMIGLSYWSTAGDIYFAKV------SNKQGSMF 430
TY H T +GE+ ++A+ W + F +V S+++ +
Sbjct: 140 HITYSI------HNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADI 193
Query: 431 SLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEG 601
+ FA H D P D GG LAHA+FP G+ HFDS E WT G
Sbjct: 194 MIFFASGFH------------GDSSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 240
Query: 602 K--EDGINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIY 775
DG +L LVA HE+GHA+GL HSNDP+A+MAP+Y Y+ ++FKLP DD QG IY
Sbjct: 241 NANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFY-QYMETHNFKLPQDDLQGIQKIY 299
Query: 776 G 778
G
Sbjct: 300 G 300
>sp|Q99PW6|MMP24_RAT Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP)
Length = 618
Score = 126 bits (317), Expect = 7e-29
Identities = 88/241 (36%), Positives = 121/241 (50%), Gaps = 19/241 (7%)
Frame = +2
Query: 113 LNDAVKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDV-----KPKNKRYNAANSKW-DK 274
L AV +Q+ G+P G +++ + + K RCG D + +NKRY KW K
Sbjct: 80 LQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQK 139
Query: 275 GTTYRFYIHDERHPTTMTLGEI--QRALMIGLSYWSTAGDIYFAKV------SNKQGSMF 430
TY H T +GE+ ++A+ W + F +V S+++ +
Sbjct: 140 HITYSI------HNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADI 193
Query: 431 SLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEG 601
+ FA H D P D GG LAHA+FP G+ HFDS E WT G
Sbjct: 194 MIFFASGFH------------GDSSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 240
Query: 602 K--EDGINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIY 775
DG +L LVA HE+GHA+GL HSNDP+A+MAP+Y Y+ ++FKLP DD QG IY
Sbjct: 241 NANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFY-QYMETHNFKLPQDDLQGIQKIY 299
Query: 776 G 778
G
Sbjct: 300 G 300
>sp|P09237|MMP7_HUMAN Matrilysin precursor (Pump-1 protease) (Uterine metalloproteinase)
(Matrix metalloproteinase-7) (MMP-7) (Matrin)
Length = 267
Score = 126 bits (316), Expect = 9e-29
Identities = 88/250 (35%), Positives = 119/250 (47%), Gaps = 9/250 (3%)
Frame = +2
Query: 65 EKFLSDFYDYNENTDRLNDA---VKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDVKPK 235
+ +L FY Y+ T N +K +QK GLP G +N ++ + K RCG DV
Sbjct: 36 QDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEY 95
Query: 236 NKRYNAANSKW-DKGTTYRF--YIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKV 406
+ N+ KW K TYR Y D H T + R + L+ W ++F KV
Sbjct: 96 SLFPNSP--KWTSKVVTYRIVSYTRDLPHIT------VDRLVSKALNMWGKEIPLHFRKV 147
Query: 407 SNKQGSMFSLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPRNG---NLHFD 577
+ + FA H D YP D PG LAHAF P G + HFD
Sbjct: 148 VWGTADIM-IGFARGAH------------GDSYPFDG-PGNTLAHAFAPGTGLGGDAHFD 193
Query: 578 SAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQ 757
E WT+G GIN A HE+GH++G+ HS+DPNA+M P YG +N FKL DD +
Sbjct: 194 EDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQN-FKLSQDDIK 252
Query: 758 GAAFIYGTKN 787
G +YG ++
Sbjct: 253 GIQKLYGKRS 262
>sp|Q9Y5R2|MMP24_HUMAN Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP)
Length = 645
Score = 124 bits (312), Expect = 3e-28
Identities = 87/241 (36%), Positives = 121/241 (50%), Gaps = 19/241 (7%)
Frame = +2
Query: 113 LNDAVKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDV-----KPKNKRYNAANSKW-DK 274
L AV +Q+ G+P G +++ + + K RCG D + +NKRY KW K
Sbjct: 107 LQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQK 166
Query: 275 GTTYRFYIHDERHPTTMTLGEI--QRALMIGLSYWSTAGDIYFAKV------SNKQGSMF 430
TY H T +GE+ ++A+ W + F +V S+++ +
Sbjct: 167 HITYSI------HNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADI 220
Query: 431 SLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEG 601
+ FA H D P D GG LAHA+FP G+ HFDS E WT G
Sbjct: 221 MIFFASGFH------------GDSSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 267
Query: 602 K--EDGINLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIY 775
DG +L LVA HE+GHA+GL HS+DP+A+MAP+Y Y+ ++FKLP DD QG IY
Sbjct: 268 NANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFY-QYMETHNFKLPQDDLQGIQKIY 326
Query: 776 G 778
G
Sbjct: 327 G 327
>sp|Q9NPA2|MMP25_HUMAN Matrix metalloproteinase-25 precursor (MMP-25) (Membrane-type
matrix metalloproteinase 6) (MT-MMP 6) (Membrane-type-6
matrix metalloproteinase) (MT6-MMP) (Leukolysin)
Length = 562
Score = 124 bits (311), Expect = 3e-28
Identities = 88/245 (35%), Positives = 125/245 (51%), Gaps = 18/245 (7%)
Frame = +2
Query: 98 ENTDRLNDAVKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDVKP------KNKRYNAAN 259
++ ++L DA+K +Q+ AGLP G+++ +A + K RC DV + +RY +
Sbjct: 53 QSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSG 112
Query: 260 SKWDKGT-TYRFYIHDERHPTTMTLG-EIQRALM-IGLSYWSTAGDIYFAKVSNKQGSM- 427
S W K T T+R P + L E R LM L W + F +V + QG
Sbjct: 113 SVWKKRTLTWRV----RSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEP 168
Query: 428 -FSLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFPR----NGNLHFDSAEEW 592
+ FA A H +D YP D + GG LAHAFFP +G+ HFD E W
Sbjct: 169 DILIDFARAFH------------QDSYPFDGL-GGTLAHAFFPGEHPISGDTHFDDEETW 215
Query: 593 TEGKEDG--INLRLVAAHEMGHAIGLFHSNDPNALMAPWYGGYISEND-FKLPDDDSQGA 763
T G +DG +L VA HE GHA+GL HS+ PN++M P+Y G + + D ++L DD G
Sbjct: 216 TFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGL 275
Query: 764 AFIYG 778
+YG
Sbjct: 276 QQLYG 280
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,267,793
Number of Sequences: 369166
Number of extensions: 2183397
Number of successful extensions: 6794
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6262
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6583
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8438301375
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)