Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_E18
(755 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8BTY1|KAT1_MOUSE Kynurenine--oxoglutarate transaminase ... 216 7e-56
sp|Q16773|KAT1_HUMAN Kynurenine--oxoglutarate transaminase ... 213 4e-55
sp|Q08415|KAT1_RAT Kynurenine--oxoglutarate transaminase I ... 212 8e-55
sp|P47039|BNA3_YEAST Probable aminotransferase BNA3 (Biosyn... 124 4e-28
sp|O14209|YDT4_SCHPO Hypothetical aminotransferase C6B12.04c 112 1e-24
sp|Q9V0L2|AAT_PYRAB Aspartate aminotransferase (Transaminas... 99 1e-20
sp|P77806|YBDL_ECOLI Hypothetical aminotransferase ybdL 90 7e-18
sp|O67781|AAT_AQUAE Aspartate aminotransferase (Transaminas... 86 1e-16
sp|P53001|AAT1_BACSU Aspartate aminotransferase (Transamina... 73 7e-13
sp|Q56232|AAT_THET8 Aspartate aminotransferase (Transaminas... 73 7e-13
>sp|Q8BTY1|KAT1_MOUSE Kynurenine--oxoglutarate transaminase I (Kynurenine
aminotransferase I) (KATI) (Glutamine--phenylpyruvate
transaminase) (Glutamine transaminase K) (GTK)
(Cysteine-S-conjugate beta-lyase)
Length = 424
Score = 216 bits (549), Expect = 7e-56
Identities = 105/228 (46%), Positives = 142/228 (62%)
Frame = +1
Query: 1 ELEMIANICKEFDLICISDEVYEWLVYPPNKHLKIASLPGMWERTITIGSIGKTLSVTGW 180
ELE++A +C++ D++C SDEVY+WLVY ++H+ IASLPGMWERT+TIGS GK+ S TGW
Sbjct: 195 ELELVAALCQQHDVLCFSDEVYQWLVYDGHQHISIASLPGMWERTLTIGSAGKSFSATGW 254
Query: 181 KLGWSIGPSNYIRGLQMVSQNCIYNCATPLQEAAARSLEIELDLLGTPKSYFSNICIELV 360
K+GW +GP N ++ L+ V QN I++C T Q A A+ E E G P SYF + +
Sbjct: 255 KVGWVMGPDNIMKHLRTVHQNSIFHCPTQAQAAVAQCFEREQQHFGQPSSYFLQLPQAMG 314
Query: 361 NKRDRMVKELVELGMNPIIPDGGYFILADFSSMVSDKFKADAKAQGIALDFFFNDWMIKN 540
RD M++ L +G+ P+IP G YF++AD S S A D F WMIKN
Sbjct: 315 LNRDHMIQSLQSVGLKPLIPQGSYFLIADISDFKSSMPDLPG-AMDEPYDTRFAKWMIKN 373
Query: 541 MKVSAIPNSCFYSKSHENIAENYIRFCFFKTDETLESAFKAFREWKNK 684
+SAIP S FYS+ H ++YIRFCF K TL++ K WK +
Sbjct: 374 KGLSAIPVSTFYSQPHHKDFDHYIRFCFVKDKATLQAMDKRLCSWKGE 421
>sp|Q16773|KAT1_HUMAN Kynurenine--oxoglutarate transaminase I (Kynurenine
aminotransferase I) (KATI) (Glutamine--phenylpyruvate
transaminase) (Glutamine transaminase K) (GTK)
(Cysteine-S-conjugate beta-lyase)
Length = 422
Score = 213 bits (542), Expect = 4e-55
Identities = 103/226 (45%), Positives = 143/226 (63%)
Frame = +1
Query: 1 ELEMIANICKEFDLICISDEVYEWLVYPPNKHLKIASLPGMWERTITIGSIGKTLSVTGW 180
ELE++A++C++ D++CI+DEVY+W+VY ++H+ IASLPGMWERT+TIGS GKT S TGW
Sbjct: 195 ELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGW 254
Query: 181 KLGWSIGPSNYIRGLQMVSQNCIYNCATPLQEAAARSLEIELDLLGTPKSYFSNICIELV 360
K+GW +GP + ++ L+ V QN +++C T Q A A S E E L P SYF +
Sbjct: 255 KVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQ 314
Query: 361 NKRDRMVKELVELGMNPIIPDGGYFILADFSSMVSDKFKADAKAQGIALDFFFNDWMIKN 540
RD M++ L +G+ PIIP G YF++ D S K A D F WMIKN
Sbjct: 315 RCRDHMIRSLQSVGLKPIIPQGSYFLITDISDF-KRKMPDLPGAVDEPYDRRFVKWMIKN 373
Query: 541 MKVSAIPNSCFYSKSHENIAENYIRFCFFKTDETLESAFKAFREWK 678
+ AIP S FYS H+ ++YIRFCF K + TL++ + R+WK
Sbjct: 374 KGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWK 419
>sp|Q08415|KAT1_RAT Kynurenine--oxoglutarate transaminase I mitochondrial precursor
(Kynurenine aminotransferase I) (KATI)
(Glutamine--phenylpyruvate transaminase) (Glutamine
transaminase K) (GTK) (Cysteine-S-conjugate beta-lyase)
Length = 457
Score = 212 bits (540), Expect = 8e-55
Identities = 103/226 (45%), Positives = 144/226 (63%)
Frame = +1
Query: 1 ELEMIANICKEFDLICISDEVYEWLVYPPNKHLKIASLPGMWERTITIGSIGKTLSVTGW 180
ELE++AN+C++ D++CISDEVY+WLVY ++H+ IASLPGMW+RT+TIGS GK+ S TGW
Sbjct: 229 ELELVANLCQQHDVVCISDEVYQWLVYDGHQHVSIASLPGMWDRTLTIGSAGKSFSATGW 288
Query: 181 KLGWSIGPSNYIRGLQMVSQNCIYNCATPLQEAAARSLEIELDLLGTPKSYFSNICIELV 360
K+GW +GP N ++ L+ V QN I++C T Q A A+ E E G P SYF + +
Sbjct: 289 KVGWVMGPDNIMKHLRTVHQNSIFHCPTQAQAAVAQCFEREQQHFGQPSSYFLQLPQAME 348
Query: 361 NKRDRMVKELVELGMNPIIPDGGYFILADFSSMVSDKFKADAKAQGIALDFFFNDWMIKN 540
RD M++ L +G+ I G YF++AD S S K A+ D F WMIKN
Sbjct: 349 LNRDHMIRSLQSVGLKLWISQGSYFLIADISDFKS-KMPDLPGAEDEPYDRRFAKWMIKN 407
Query: 541 MKVSAIPNSCFYSKSHENIAENYIRFCFFKTDETLESAFKAFREWK 678
M + IP S F+S+ H+ ++YIRFCF K TL++ + R+WK
Sbjct: 408 MGLVGIPVSTFFSRPHQKDFDHYIRFCFVKDKATLQAMDERLRKWK 453
>sp|P47039|BNA3_YEAST Probable aminotransferase BNA3 (Biosynthesis of nicotinic acid
protein 3)
Length = 444
Score = 124 bits (310), Expect = 4e-28
Identities = 78/230 (33%), Positives = 121/230 (52%), Gaps = 3/230 (1%)
Frame = +1
Query: 1 ELEMIANICKEFDLICISDEVYEWLVYPPNKHLKIASL-PGMWERTITIGSIGKTLSVTG 177
EL + NIC + +++ ISDEVYE L Y + +IA+L P + + T+T+GS GK+ + TG
Sbjct: 219 ELTTLGNICVKHNVVIISDEVYEHL-YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATG 277
Query: 178 WKLGWSIGPSNYIRGLQMVSQNCI-YNCATPLQEAAARSLEIELDLLGTPKSYFSNICIE 354
W++GW + + + + I + +PLQEA A S+ L + YF + E
Sbjct: 278 WRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKI-----GYFEKMRQE 332
Query: 355 LVNKRDRMVKELVELGMNPIIPDGGYFILADFSSM-VSDKFKADAKAQGIALDFFFNDWM 531
+NK ELG+ P+G YF+L DFS + + + + + DF + W+
Sbjct: 333 YINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWL 392
Query: 532 IKNMKVSAIPNSCFYSKSHENIAENYIRFCFFKTDETLESAFKAFREWKN 681
I + V AIP + FY K HE AEN +RF K D LE+A + + K+
Sbjct: 393 INELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKD 442
>sp|O14209|YDT4_SCHPO Hypothetical aminotransferase C6B12.04c
Length = 421
Score = 112 bits (280), Expect = 1e-24
Identities = 72/230 (31%), Positives = 121/230 (52%), Gaps = 3/230 (1%)
Frame = +1
Query: 1 ELEMIANICKEFDLICISDEVYEWLVYPPNKHLKIASL-PGMWERTITIGSIGKTLSVTG 177
EL IA++ + +L+ +SDEVY+ L + P +++A+L P +++ +T+GS GKT TG
Sbjct: 198 ELNEIADLVLKHNLLVVSDEVYDRLSFVP--FVRLATLRPELFKHVVTVGSGGKTFGCTG 255
Query: 178 WKLGWSIGPSNYIRGLQMVSQNCIYNCATPLQEAAARSL-EIELDLLGTPKSYFSNICIE 354
W++GW IG + I+ + +P QEA A + E E +Y+
Sbjct: 256 WRVGWLIGDESLIKYSAAAHTRICFAVNSPCQEALAIAFGEAE------KHNYYEEYKSS 309
Query: 355 LVNKRDRMVKELVELGMNPIIPDGGYFILADFSSMVSDK-FKADAKAQGIALDFFFNDWM 531
+ + + K +L + IPDG Y+ +A+FS + K + + DF W+
Sbjct: 310 YKKRFEILAKAFDQLEIPYTIPDGSYYTMANFSKLKLPKDYPFPEEIANRPRDFKLCYWI 369
Query: 532 IKNMKVSAIPNSCFYSKSHENIAENYIRFCFFKTDETLESAFKAFREWKN 681
+K + V+ IP + FY+ +AENY+RF F KT ETLE A + ++ K+
Sbjct: 370 LKEIGVATIPPTEFYTDEDAPVAENYLRFAFCKTFETLEEAARRLQKLKD 419
>sp|Q9V0L2|AAT_PYRAB Aspartate aminotransferase (Transaminase A) (AspAT)
Length = 389
Score = 99.0 bits (245), Expect = 1e-20
Identities = 78/233 (33%), Positives = 108/233 (46%), Gaps = 7/233 (3%)
Frame = +1
Query: 1 ELEMIANICKEFDLICISDEVYEWLVYPPNKHLKIASLPGMWERTITIGSIGKTLSVTGW 180
+LE IA+ E DLI ISDEVYE +Y KH IASL GM+ERTIT+ KT ++TGW
Sbjct: 181 DLEEIADFAVEHDLIVISDEVYEHFIYDDVKHYSIASLDGMFERTITVNGFSKTFAMTGW 240
Query: 181 KLGWSIGPSNYIRGL---QMVSQNCIYNCATPLQEAAARSLEIELDLLGTPKSYFSNICI 351
+LG+ PS I + QM + C T +Q AAA++L E +
Sbjct: 241 RLGFVAAPSWIIEKMVKFQMYNATC---PVTFIQYAAAKALRDERSWKAV-----EEMRK 292
Query: 352 ELVNKRDRMVKELVELGMNPIIPDGGYFILADFSSMVSDKFKADAKAQGIALDFFFNDWM 531
E +R + K L E+G+ + P G ++I K G+ F++ M
Sbjct: 293 EYDRRRKLVWKRLNEMGLPTVKPKGAFYIFPRI------------KDTGLT-SKEFSELM 339
Query: 532 IKNMKVSAIPNSCFYSKSHENIAENYIRFCFFKTDETLESAF----KAFREWK 678
+ KV+ +P S F E Y+R + E LE A K RE K
Sbjct: 340 LMEAKVAVVPGSAF-----GKAGEGYVRISYATAYEKLEEAMDRMEKVLREKK 387
>sp|P77806|YBDL_ECOLI Hypothetical aminotransferase ybdL
Length = 386
Score = 89.7 bits (221), Expect = 7e-18
Identities = 64/213 (30%), Positives = 98/213 (46%), Gaps = 1/213 (0%)
Frame = +1
Query: 37 DLICISDEVYEWLVYPPNKHLKIASLPGMWERTITIGSIGKTLSVTGWKLGWSIGPSNYI 216
++ ISDEVYE + + H + + P + ER + + S GKT +TGWK+G+ + P+
Sbjct: 196 EIFVISDEVYEHINFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCVAPAPIS 255
Query: 217 RGLQMVSQNCIYNCATPLQEAAARSLEIELD-LLGTPKSYFSNICIELVNKRDRMVKELV 393
++ V Q ++ TP Q A A L E + L P Y KRD +V L
Sbjct: 256 AEIRKVHQYLTFSVNTPAQLALADMLRAEPEHYLALPDFY--------RQKRDILVNALN 307
Query: 394 ELGMNPIIPDGGYFILADFSSMVSDKFKADAKAQGIALDFFFNDWMIKNMKVSAIPNSCF 573
E + + +G YF+L D+S A D F W+ + V+AIP S F
Sbjct: 308 ESRLEILPCEGTYFLLVDYS------------AVSTLDDVEFCQWLTQEHGVAAIPLSVF 355
Query: 574 YSKSHENIAENYIRFCFFKTDETLESAFKAFRE 672
+ + IR CF K + TL +A + R+
Sbjct: 356 CA---DPFPHKLIRLCFAKKESTLLAAAERLRQ 385
>sp|O67781|AAT_AQUAE Aspartate aminotransferase (Transaminase A) (ASPAT)
Length = 394
Score = 85.9 bits (211), Expect = 1e-16
Identities = 62/218 (28%), Positives = 104/218 (47%), Gaps = 13/218 (5%)
Frame = +1
Query: 1 ELEMIANICKEFDLICISDEVYEWLVYPPNKHLKIASLPGMWER-TITIGSIGKTLSVTG 177
EL+ IA C E + ISDE YE+ VY K + AS + T T+ + K+ S+TG
Sbjct: 186 ELKKIAEFCVERGIFIISDECYEYFVYGDAKFVSPASFSDEVKNITFTVNAFSKSYSMTG 245
Query: 178 WKLGWSIGPSNYIRGLQMVSQNCIYNCATPLQEAAARSLEIELDLLGTPKS--YFSNICI 351
W++G+ P Y + + ++ + N T Q A L+ L PKS + + +
Sbjct: 246 WRIGYVACPEEYAKVIASLNSQSVSNVTTFAQYGA-------LEALKNPKSKDFVNEMRN 298
Query: 352 ELVNKRDRMVKELVEL-GMNPIIPDGGYFILADFSSMVSDKFKADAKAQGIALDFFFNDW 528
+RD V+EL ++ GM+ + P+G ++I DFS A A+ + D +++
Sbjct: 299 AFERRRDTAVEELSKIPGMDVVKPEGAFYIFPDFS----------AYAEKLGGDVKLSEF 348
Query: 529 MIKNMKVSAIPNSCF---------YSKSHENIAENYIR 615
+++ KV+ +P S F Y+ S E + E R
Sbjct: 349 LLEKAKVAVVPGSAFGAPGFLRLSYALSEERLVEGIRR 386
>sp|P53001|AAT1_BACSU Aspartate aminotransferase (Transaminase A) (ASPAT)
Length = 393
Score = 73.2 bits (178), Expect = 7e-13
Identities = 53/231 (22%), Positives = 110/231 (47%), Gaps = 2/231 (0%)
Frame = +1
Query: 1 ELEMIANICKEFDLICISDEVYEWLVYPPNKHLKIASLPG-MWERTITIGSIGKTLSVTG 177
EL + +C E D++ +SDE+YE L Y KH+ IA L + E+T+ I + K+ S+TG
Sbjct: 184 ELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSIAQLSDRLKEQTVIINGVSKSHSMTG 243
Query: 178 WKLGWSIGPSNYIRGLQMVSQNCIYNCATPLQEAAARSLEIELDLLGTPKSYFSNICIEL 357
W++G++ G + I+ + ++ + N + Q A + + L + F
Sbjct: 244 WRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQYGAIAAYNGPSEPLEEMREAFE------ 297
Query: 358 VNKRDRMVKELVEL-GMNPIIPDGGYFILADFSSMVSDKFKADAKAQGIALDFFFNDWMI 534
++ + + +L+E+ G + + P+G +++ + K A++ G F ++
Sbjct: 298 -HRLNTIYAKLIEIPGFSCVKPEGAFYLFPN--------AKEAAQSCGFKDVDEFVKALL 348
Query: 535 KNMKVSAIPNSCFYSKSHENIAENYIRFCFFKTDETLESAFKAFREWKNKN 687
+ KV+ +P S F S + +R + + + LE A + + + K+
Sbjct: 349 EEEKVAIVPGSGFGSPEN-------VRLSYATSLDLLEEAIERIKRFVEKH 392
>sp|Q56232|AAT_THET8 Aspartate aminotransferase (Transaminase A) (ASPAT)
Length = 385
Score = 73.2 bits (178), Expect = 7e-13
Identities = 51/221 (23%), Positives = 95/221 (42%)
Frame = +1
Query: 4 LEMIANICKEFDLICISDEVYEWLVYPPNKHLKIASLPGMWERTITIGSIGKTLSVTGWK 183
LE +A + E D +SDE+YE L+Y P E T+T+ K ++TGW+
Sbjct: 186 LEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAP---EHTLTVNGAAKAFAMTGWR 242
Query: 184 LGWSIGPSNYIRGLQMVSQNCIYNCATPLQEAAARSLEIELDLLGTPKSYFSNICIELVN 363
+G++ GP I+ + VS + T Q A +L + +++
Sbjct: 243 IGYACGPKEVIKAMASVSSQSTTSPDTIAQWATLEALTNQ----EASRAFVEMAREAYRR 298
Query: 364 KRDRMVKELVELGMNPIIPDGGYFILADFSSMVSDKFKADAKAQGIALDFFFNDWMIKNM 543
+RD +++ L LG+ + P G +++L D S + D+ +A + +
Sbjct: 299 RRDLLLEGLTALGLKAVRPSGAFYVLMDTSPIAPDEVRAAER--------------LLEA 344
Query: 544 KVSAIPNSCFYSKSHENIAENYIRFCFFKTDETLESAFKAF 666
V+ +P + F + H +R + ++E L A + F
Sbjct: 345 GVAVVPGTDFAAFGH-------VRLSYATSEENLRKALERF 378
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,820,063
Number of Sequences: 369166
Number of extensions: 1952137
Number of successful extensions: 4689
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4539
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4654
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6921714800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)