Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_E12
(784 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q99611|SPS2_HUMAN Selenide, water dikinase 2 (Selenophos... 204 2e-52
sp|P97364|SPS2_MOUSE Selenide, water dikinase 2 (Selenophos... 202 6e-52
sp|P49903|SPS1_HUMAN Selenide, water dikinase 1 (Selenophos... 198 2e-50
sp|Q8BH69|SPS1_MOUSE Selenide, water dikinase 1 (Selenophos... 198 2e-50
sp|O18373|SPS1_DROME Selenide, water dikinase (Selenophosph... 191 2e-48
sp|Q94497|SELD_DICDI Selenide, water dikinase (Selenophosph... 187 2e-47
sp|O62461|SELD_CAEEL Probable selenide, water dikinase (Sel... 178 2e-44
sp|Q9VKY8|SPS2_DROME Selenide, water dikinase 2 (Selenophos... 171 2e-42
sp|Q8TVM0|SELD_METKA Selenide, water dikinase (Selenophosph... 109 7e-24
sp|P60819|SELD_METJA Selenide, water dikinase (Selenophosph... 106 6e-23
>sp|Q99611|SPS2_HUMAN Selenide, water dikinase 2 (Selenophosphate synthetase 2) (Selenium
donor protein 2)
Length = 448
Score = 204 bits (520), Expect = 2e-52
Identities = 109/208 (52%), Positives = 141/208 (67%), Gaps = 7/208 (3%)
Frame = +1
Query: 1 VTGGQTVVNPWLIIGGVATAVCPINEIIMPNNAEIGDVLVLTKPLGTQVAVNAYQWMNDK 180
VTGGQTVVNPW+IIGGVAT VC NE IMP++A +GDVLVLTKPLGTQVAVNA+QW+ D
Sbjct: 210 VTGGQTVVNPWIIIGGVATVVCQPNEFIMPDSAVVGDVLVLTKPLGTQVAVNAHQWL-DN 268
Query: 181 TPRYEKIKHILTDKEIDSLFETATKQMATLNQKGAQLMHKYAAKACTDVTGFGILGHATN 360
R+ K+K +++ +E++ ++ A MATLN+ A LMH + A A TD+TGFGILGH+ N
Sbjct: 269 PERWNKVKMVVSREEVELAYQEAMFNMATLNRTAAGLMHTFNAHAATDITGFGILGHSQN 328
Query: 361 LVECQLASVDFLIEKLPCLQYTMAIDDVLDGAMKLRRGFSPETSGGLFIVLKKENAEKFV 540
L + Q V F+I LP + A+ G L +G S ETSGGL I L +E A +F
Sbjct: 329 LAKQQRNEVSFVIHNLPIIAKMAAVSKA-SGRFGLLQGTSAETSGGLLICLpreQAARFC 387
Query: 541 SEMPSN-------AWIIGRVESGSRCAK 603
SE+ S+ AWI+G VE G+R A+
Sbjct: 388 SEIKSSKYGEGHQAWIVGIVEKGNRTAR 415
>sp|P97364|SPS2_MOUSE Selenide, water dikinase 2 (Selenophosphate synthetase 2) (Selenium
donor protein 2)
Length = 452
Score = 202 bits (515), Expect = 6e-52
Identities = 109/208 (52%), Positives = 140/208 (67%), Gaps = 7/208 (3%)
Frame = +1
Query: 1 VTGGQTVVNPWLIIGGVATAVCPINEIIMPNNAEIGDVLVLTKPLGTQVAVNAYQWMNDK 180
VTGGQTVVNPW+IIGGVAT VC NE IMP++A +GDVLVLTKPLGTQVA NA+QW+ D
Sbjct: 213 VTGGQTVVNPWIIIGGVATVVCQQNEFIMPDSAVVGDVLVLTKPLGTQVAANAHQWL-DN 271
Query: 181 TPRYEKIKHILTDKEIDSLFETATKQMATLNQKGAQLMHKYAAKACTDVTGFGILGHATN 360
++ KIK +++ +E++ ++ A MATLN+ A LMH + A A TD+TGFGILGH+ N
Sbjct: 272 PEKWNKIKMVVSREEVELAYQEAMFNMATLNRTAAGLMHTFNAHAATDITGFGILGHSQN 331
Query: 361 LVECQLASVDFLIEKLPCLQYTMAIDDVLDGAMKLRRGFSPETSGGLFIVLKKENAEKFV 540
L + Q V F+I LP + AI G L +G S ETSGGL I L +E A +F
Sbjct: 332 LAKQQKNEVSFVIHNLPIIAKMAAISKA-SGRFGLLQGTSAETSGGLLICLpreQAARFC 390
Query: 541 SEMPSN-------AWIIGRVESGSRCAK 603
SE+ S+ AWI+G VE G+R A+
Sbjct: 391 SEIKSSKYGEGHQAWIVGIVEKGNRTAR 418
>sp|P49903|SPS1_HUMAN Selenide, water dikinase 1 (Selenophosphate synthetase 1) (Selenium
donor protein 1)
Length = 392
Score = 198 bits (503), Expect = 2e-50
Identities = 105/208 (50%), Positives = 134/208 (64%), Gaps = 7/208 (3%)
Frame = +1
Query: 1 VTGGQTVVNPWLIIGGVATAVCPINEIIMPNNAEIGDVLVLTKPLGTQVAVNAYQWMNDK 180
VTGGQTV+NPW+++GGVAT VC NE IMP+NA GDVLVLTKPLGTQVAV +QW+ D
Sbjct: 159 VTGGQTVLNPWIVLGGVATTVCQPNEFIMPDNAVPGDVLVLTKPLGTQVAVAVHQWL-DI 217
Query: 181 TPRYEKIKHILTDKEIDSLFETATKQMATLNQKGAQLMHKYAAKACTDVTGFGILGHATN 360
++ KIK ++T ++++ ++ A MA LN+ A LMH + A A TD+TGFGILGHA N
Sbjct: 218 PEKWNKIKLVVTQEDVELAYQEAMMNMARLNRTAAGLMHTFNAHAATDITGFGILGHAQN 277
Query: 361 LVECQLASVDFLIEKLPCLQYTMAIDDVLDGAMKLRRGFSPETSGGLFIVLKKENAEKFV 540
L + Q V F+I LP L A+ L G PETSGGL I L +E A +F
Sbjct: 278 LAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETSGGLLICLpreQAARFC 337
Query: 541 SEMPS-------NAWIIGRVESGSRCAK 603
+E+ S AWIIG VE G+R A+
Sbjct: 338 AEIKSPKYGEGHQAWIIGIVEKGNRTAR 365
>sp|Q8BH69|SPS1_MOUSE Selenide, water dikinase 1 (Selenophosphate synthetase 1) (Selenium
donor protein 1)
Length = 392
Score = 198 bits (503), Expect = 2e-50
Identities = 105/208 (50%), Positives = 134/208 (64%), Gaps = 7/208 (3%)
Frame = +1
Query: 1 VTGGQTVVNPWLIIGGVATAVCPINEIIMPNNAEIGDVLVLTKPLGTQVAVNAYQWMNDK 180
VTGGQTV+NPW+++GGVAT VC NE IMP+NA GDVLVLTKPLGTQVAV +QW+ D
Sbjct: 159 VTGGQTVLNPWIVLGGVATTVCQPNEFIMPDNAVPGDVLVLTKPLGTQVAVAVHQWL-DI 217
Query: 181 TPRYEKIKHILTDKEIDSLFETATKQMATLNQKGAQLMHKYAAKACTDVTGFGILGHATN 360
++ KIK ++T ++++ ++ A MA LN+ A LMH + A A TD+TGFGILGHA N
Sbjct: 218 PEKWNKIKLVVTQEDVELAYQEAMMNMARLNRTAAGLMHTFNAHAATDITGFGILGHAQN 277
Query: 361 LVECQLASVDFLIEKLPCLQYTMAIDDVLDGAMKLRRGFSPETSGGLFIVLKKENAEKFV 540
L + Q V F+I LP L A+ L G PETSGGL I L +E A +F
Sbjct: 278 LAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETSGGLLICLpreQAARFC 337
Query: 541 SEMPS-------NAWIIGRVESGSRCAK 603
+E+ S AWIIG VE G+R A+
Sbjct: 338 AEIKSPKYGEGHQAWIIGIVEKGNRTAR 365
>sp|O18373|SPS1_DROME Selenide, water dikinase (Selenophosphate synthetase) (Selenium
donor protein) (Patufet protein) (dSelD)
Length = 398
Score = 191 bits (485), Expect = 2e-48
Identities = 98/205 (47%), Positives = 133/205 (64%), Gaps = 4/205 (1%)
Frame = +1
Query: 1 VTGGQTVVNPWLIIGGVATAVCPINEIIMPNNAEIGDVLVLTKPLGTQVAVNAYQWMNDK 180
VTGGQ+VVNPW IGGVA+ +C NE I+P+NA +GDVLVLTKPLGTQVAVNA+QW+ D+
Sbjct: 181 VTGGQSVVNPWCTIGGVASTICQPNEYIVPDNAVVGDVLVLTKPLGTQVAVNAHQWI-DQ 239
Query: 181 TPRYEKIKHILTDKEIDSLFETATKQMATLNQKGAQLMHKYAAKACTDVTGFGILGHATN 360
R+ +IK +++++++ + A MA LN+ A+LMHKY A TD+TGFG+LGHA
Sbjct: 240 PERWNRIKLVVSEEDVRKAYHRAMNSMARLNRVAARLMHKYNAHGATDITGFGLLGHAQT 299
Query: 361 LVECQLASVDFLIEKLPCLQYTMAIDDVLDGAMKLRRGFSPETSGGLFIVLKKENAEKFV 540
L Q V F+I LP + A+ +L +G S ETSGGL I L +E A +
Sbjct: 300 LAAHQKKDVSFVIHNLPVIAKMAAVAKACGNMFQLLQGHSAETSGGLLICLpreQAAAYC 359
Query: 541 SEMPS----NAWIIGRVESGSRCAK 603
++ AWIIG VE G++ A+
Sbjct: 360 KDIEKQEGYQAWIIGIVEKGNKTAR 384
>sp|Q94497|SELD_DICDI Selenide, water dikinase (Selenophosphate synthetase) (Selenium
donor protein)
Length = 370
Score = 187 bits (476), Expect = 2e-47
Identities = 104/197 (52%), Positives = 128/197 (64%), Gaps = 4/197 (2%)
Frame = +1
Query: 1 VTGGQTVVNPWLIIGGVATAVCPINEIIMPNNAEIGDVLVLTKPLGTQVAVNAYQWMNDK 180
V+GGQTV NPW I+GGVAT++ NE I P NA GDVLVLT PLGTQ VN +QW++ K
Sbjct: 173 VSGGQTVKNPWPIVGGVATSILKTNEFIKPVNAVPGDVLVLTNPLGTQFCVNFHQWLS-K 231
Query: 181 TPRYEKIKHILTDKEIDSLFETATKQMATLNQKGAQLMHKYAAKACTDVTGFGILGHATN 360
R EKI I KE + +F AT MA LN+ GA+LM Y A A TDVTGFGILGH+TN
Sbjct: 232 PKRGEKINTITNAKECEQVFNYATLSMAKLNRVGAKLMKNYNAHAATDVTGFGILGHSTN 291
Query: 361 LVECQLASVDFLIEKLPCLQYTMAIDDVLDGAMKLRRGFSPETSGGLFIVLKKENAEKFV 540
L + QL + F I LP +++ ++D L+ KL +G S ETSGGL I + +ENAE F
Sbjct: 292 LAQNQLLPIRFEIHTLPIIKHMKKLEDHLNHPFKLLKGTSAETSGGLLISMSRENAEAFC 351
Query: 541 SEM----PSNAWIIGRV 579
E+ AWIIG V
Sbjct: 352 KEIYEIEKQPAWIIGDV 368
>sp|O62461|SELD_CAEEL Probable selenide, water dikinase (Selenophosphate synthetase)
(Selenium donor protein)
Length = 378
Score = 178 bits (451), Expect = 2e-44
Identities = 95/201 (47%), Positives = 134/201 (66%), Gaps = 8/201 (3%)
Frame = +1
Query: 1 VTGGQTVVNPWLIIGGVATAVCPINEIIMPNNAEIGDVLVLTKPLGTQVAVNAYQWMNDK 180
+ GGQTV PWL++GGVAT+V +EII + A GDVL+LTKP+G QVAVN+Y+W+ K
Sbjct: 155 IRGGQTVRCPWLLLGGVATSVAHESEIIKVDQAVPGDVLILTKPIGGQVAVNSYEWIKKK 214
Query: 181 TPRYEKIKHILTDKEIDSLFETATKQMATLNQKGAQLMHKYAAKACTDVTGFGILGHATN 360
+ E++ L +I+ F+ +QM+ LN+ A+L+HKY A + TDVTGFG+LGHA N
Sbjct: 215 NGKIEELN--LEIPKIEKAFKQVCEQMSRLNRNAAKLLHKYDAHSSTDVTGFGLLGHAEN 272
Query: 361 LVECQLASVDFLIEKLPCLQYTMAIDDVL----DGAMKLRRGFSPETSGGLFIVLKKENA 528
L Q ++F+IEKLP ++Y I D + KL +G S ETSGGL I + +ENA
Sbjct: 273 LARVQKQPMEFIIEKLPIIEYMDEIADKMIAKGGEGFKLYQGTSAETSGGLLIAMSEENA 332
Query: 529 EKFVSEMPS----NAWIIGRV 579
+K+++E+ S AWIIG+V
Sbjct: 333 KKYIAELSSLDNAPAWIIGKV 353
>sp|Q9VKY8|SPS2_DROME Selenide, water dikinase 2 (Selenophosphate synthetase 2) (Selenium
donor protein 2) (Dsps2)
Length = 370
Score = 171 bits (433), Expect = 2e-42
Identities = 86/175 (49%), Positives = 115/175 (65%)
Frame = +1
Query: 13 QTVVNPWLIIGGVATAVCPINEIIMPNNAEIGDVLVLTKPLGTQVAVNAYQWMNDKTPRY 192
Q +NPW IIGG+AT+VC EII+P+NA+ GDVLVLTKPLG Q+A++A+ W ++T +Y
Sbjct: 155 QLKINPWCIIGGIATSVCRSEEIILPSNAQPGDVLVLTKPLGGQMAMDAHLWQLNQTEKY 214
Query: 193 EKIKHILTDKEIDSLFETATKQMATLNQKGAQLMHKYAAKACTDVTGFGILGHATNLVEC 372
+K+ +D +I FE A K M LN+ A LMHKY A TD+TGFG+LGHA NL +
Sbjct: 215 KKLLSECSDADIKETFEIAVKSMTYLNKNAALLMHKYQAHCATDITGFGLLGHANNLAQF 274
Query: 373 QLASVDFLIEKLPCLQYTMAIDDVLDGAMKLRRGFSPETSGGLFIVLKKENAEKF 537
Q V F I KLP ++ + ++ + K R G S ETSGGL I L + A+KF
Sbjct: 275 QKEKVLFQINKLPIIKNVLKFSTLVGQSTKFRSGRSVETSGGLLICLPADAADKF 329
>sp|Q8TVM0|SELD_METKA Selenide, water dikinase (Selenophosphate synthetase) (Selenium
donor protein)
Length = 334
Score = 109 bits (273), Expect = 7e-24
Identities = 74/200 (37%), Positives = 101/200 (50%), Gaps = 3/200 (1%)
Frame = +1
Query: 1 VTGGQTVVNPWLIIGGVATAVCPINEIIMPNNAEIGDVLVLTKPLGTQVAVNAYQWMNDK 180
+ GG T++NPW I+GG T + AE GDVL LTKPLGTQ A+ A + D
Sbjct: 132 IVGGHTIMNPWPILGGCVTGFA--ERYVTVGGAEPGDVLYLTKPLGTQPAMAALRLPEDV 189
Query: 181 TPRYEKIKHILTDKEIDSLFETATKQMATLNQKGAQLMHKYAAKACTDVTGFGILGHATN 360
K LTD E++ + A + M + A+ + A TDVTGFG+ GHA
Sbjct: 190 R------KQFLTDSELEEAVDLAVEVMTEPLKDAAEAALEVGVHAMTDVTGFGLKGHAGE 243
Query: 361 LVECQLASVDFLIEKLPCLQYTMAIDDVLDGAMKLRRGFSPETSGGLFIVLKKENAEKFV 540
+ E + V +IE+LP + T + L L RG S ET+GGL + + +E+AE
Sbjct: 244 MAEA--SGVRVVIERLPVIPGTTELSRAL--GYGLERGESAETAGGLLVAVPEEHAEDLE 299
Query: 541 SEMP-SNAWI--IGRVESGS 591
+ W IGRVE GS
Sbjct: 300 DAFERRDVWYRRIGRVEEGS 319
>sp|P60819|SELD_METJA Selenide, water dikinase (Selenophosphate synthetase) (Selenium
donor protein)
Length = 349
Score = 106 bits (265), Expect = 6e-23
Identities = 68/203 (33%), Positives = 105/203 (51%), Gaps = 10/203 (4%)
Frame = +1
Query: 1 VTGGQTVVNPWLIIGGVATAVCPINEIIMPNNAEIGDVLVLTKPLGTQVAVNAYQWMNDK 180
+ GG T++NPW +IGG T V E++ ++GDVL+LTKPLGTQ A+ +
Sbjct: 137 IVGGHTILNPWPLIGGAVTGVGREEEVLTKAGVKVGDVLILTKPLGTQTAMAL-----SR 191
Query: 181 TPRYEKIKHILTDKEIDSLFETATKQMATLNQKGAQLMHK-------YAAKACTDVTGFG 339
P K +T++E D + A + M T N+ + + K A A TD+TGFG
Sbjct: 192 IPEEFKDLISITEEERDYIINKAIEIMTTSNRYALKALRKAEERVGDKIANALTDITGFG 251
Query: 340 ILGHATNLVECQLASVDFLIEKLPCLQYTMAIDDVLDGAMKLRRGFSPETSGGLFIVLKK 519
ILGH+ + + ++ I LPC++ T + + A L G+ ET+GGL I K+
Sbjct: 252 ILGHSNEMAKNSNVLIE--INLLPCIKRTPELSRLFGHA--LLDGYGAETAGGLLISAKE 307
Query: 520 ENAEKFVSEMPS---NAWIIGRV 579
E + + E+ A+ +GRV
Sbjct: 308 EYKDNLIDELEKAKCYAFEVGRV 330
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,929,111
Number of Sequences: 369166
Number of extensions: 2007577
Number of successful extensions: 5989
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5792
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5926
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7357347200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)