Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_E10
(653 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q60HG7|CGL_MACFA Cystathionine gamma-lyase (Gamma-cystat... 183 3e-46
sp|Q8VCN5|CGL_MOUSE Cystathionine gamma-lyase (Gamma-cystat... 183 4e-46
sp|P18757|CGL_RAT Cystathionine gamma-lyase (Gamma-cystathi... 181 1e-45
sp|P32929|CGL_HUMAN Cystathionine gamma-lyase (Gamma-cystat... 179 4e-45
sp|P55216|CGL_CAEEL Putative cystathionine gamma-lyase (Gam... 177 3e-44
sp|P66876|METB_MYCBO Cystathionine gamma-synthase (CGS) (O-... 150 2e-36
sp|P56069|METB_HELPY Cystathionine gamma-synthase (CGS) (O-... 147 2e-35
sp|P46807|METB_MYCLE Cystathionine gamma-synthase (CGS) (O-... 145 1e-34
sp|Q9ZMW7|METB_HELPJ Cystathionine gamma-synthase (CGS) (O-... 141 1e-33
sp|P0A4K3|METC_LACLC Cystathionine beta-lyase (CBL) (Beta-c... 136 4e-32
>sp|Q60HG7|CGL_MACFA Cystathionine gamma-lyase (Gamma-cystathionase)
Length = 405
Score = 183 bits (465), Expect = 3e-46
Identities = 95/177 (53%), Positives = 125/177 (70%)
Frame = +2
Query: 2 SDVLMGAAAMNNEGLYESLRQQQLMVGAVPSPFDCYLALRGLRTLVVRMTQHQLNGLAVA 181
SDV+MG ++N E L+ LR Q +GAVPSP DCYL RGL+TL VRM +H NG+AVA
Sbjct: 218 SDVVMGLVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVA 277
Query: 182 LFLADHPKIEKVLHPALFPSPQKEIIAKQMTGFSGMLSAYVKGSHEDIVDFMKNLKYFPI 361
FL +P +EKV++P L PQ E+ +Q TG +GM++ Y+KG+ + F+KNLK F +
Sbjct: 278 QFLESNPGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEIFLKNLKLFTL 337
Query: 362 AKSLGGFESLIEIPSLMTYTSVPLDKCVELGICDNLVRFSVGLEDIYSLLEDLDNGL 532
A+SLGGFESL+E+P++MT+ SVP + LGI D L+R SVGLED LLEDLD L
Sbjct: 338 AESLGGFESLVELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQAL 394
>sp|Q8VCN5|CGL_MOUSE Cystathionine gamma-lyase (Gamma-cystathionase)
Length = 398
Score = 183 bits (464), Expect = 4e-46
Identities = 94/177 (53%), Positives = 124/177 (70%)
Frame = +2
Query: 2 SDVLMGAAAMNNEGLYESLRQQQLMVGAVPSPFDCYLALRGLRTLVVRMTQHQLNGLAVA 181
SDV+MG ++N++ L LR Q +GAVPSPFDCYL RGL+TL VRM +H NG+AVA
Sbjct: 217 SDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVA 276
Query: 182 LFLADHPKIEKVLHPALFPSPQKEIIAKQMTGFSGMLSAYVKGSHEDIVDFMKNLKYFPI 361
FL +P++EKV++P L PQ E+ +Q +G GM+S Y+KG+ + F+KNLK F +
Sbjct: 277 RFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTL 336
Query: 362 AKSLGGFESLIEIPSLMTYTSVPLDKCVELGICDNLVRFSVGLEDIYSLLEDLDNGL 532
A+SLGG+ESL E+P++MT+ SVP LGI D L+R SVGLED LLEDLD L
Sbjct: 337 AESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRAL 393
>sp|P18757|CGL_RAT Cystathionine gamma-lyase (Gamma-cystathionase) (Probasin-related
antigen) (PRB-RA)
Length = 398
Score = 181 bits (459), Expect = 1e-45
Identities = 92/177 (51%), Positives = 123/177 (69%)
Frame = +2
Query: 2 SDVLMGAAAMNNEGLYESLRQQQLMVGAVPSPFDCYLALRGLRTLVVRMTQHQLNGLAVA 181
SDV+MG ++ ++ L E LR Q +GAVPSPFDCYL RGL+TL +RM +H NG+AVA
Sbjct: 217 SDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVA 276
Query: 182 LFLADHPKIEKVLHPALFPSPQKEIIAKQMTGFSGMLSAYVKGSHEDIVDFMKNLKYFPI 361
FL +P++EKV++P L PQ E+ +Q TG GM+S Y+KG+ + F+KN+K F +
Sbjct: 277 RFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFAL 336
Query: 362 AKSLGGFESLIEIPSLMTYTSVPLDKCVELGICDNLVRFSVGLEDIYSLLEDLDNGL 532
A+SLGG+ESL E+P++MT+ SVP LGI D L+R SVGLED LLEDL L
Sbjct: 337 AESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQAL 393
>sp|P32929|CGL_HUMAN Cystathionine gamma-lyase (Gamma-cystathionase)
Length = 405
Score = 179 bits (455), Expect = 4e-45
Identities = 94/177 (53%), Positives = 124/177 (70%)
Frame = +2
Query: 2 SDVLMGAAAMNNEGLYESLRQQQLMVGAVPSPFDCYLALRGLRTLVVRMTQHQLNGLAVA 181
SDV+MG ++N E L+ LR Q +GAVPSP DCYL RGL+TL VRM +H NG+AVA
Sbjct: 218 SDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVA 277
Query: 182 LFLADHPKIEKVLHPALFPSPQKEIIAKQMTGFSGMLSAYVKGSHEDIVDFMKNLKYFPI 361
FL +P +EKV++P L PQ E++ +Q TG +GM++ Y+KG+ + F+KNLK F +
Sbjct: 278 QFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTL 337
Query: 362 AKSLGGFESLIEIPSLMTYTSVPLDKCVELGICDNLVRFSVGLEDIYSLLEDLDNGL 532
A+SLGGFESL E+P++MT+ SV + LGI D L+R SVGLED LLEDLD L
Sbjct: 338 AESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQAL 394
>sp|P55216|CGL_CAEEL Putative cystathionine gamma-lyase (Gamma-cystathionase)
Length = 392
Score = 177 bits (448), Expect = 3e-44
Identities = 92/177 (51%), Positives = 121/177 (68%)
Frame = +2
Query: 2 SDVLMGAAAMNNEGLYESLRQQQLMVGAVPSPFDCYLALRGLRTLVVRMTQHQLNGLAVA 181
SDV+MGA +N+ + L QL VGAVPSPFDC+L RGL+TL +RM H N LAVA
Sbjct: 209 SDVVMGAVITDNDEFQQHLFFMQLAVGAVPSPFDCFLVNRGLKTLHIRMRAHYENALAVA 268
Query: 182 LFLADHPKIEKVLHPALFPSPQKEIIAKQMTGFSGMLSAYVKGSHEDIVDFMKNLKYFPI 361
+L + +IE VL+PAL PQ E+ KQ G SGM+S Y+KG ++ F+ LK F +
Sbjct: 269 KYLEANDRIESVLYPALPSHPQHEVHEKQTKGMSGMISFYLKGELQESRAFLSALKVFTL 328
Query: 362 AKSLGGFESLIEIPSLMTYTSVPLDKCVELGICDNLVRFSVGLEDIYSLLEDLDNGL 532
A+SLGG+ESL E+PS+MT+ SVP + + LGI DNL+R SVG+ED+ L+ DLD L
Sbjct: 329 AESLGGYESLAELPSIMTHASVPAETRIVLGITDNLIRISVGIEDLDDLVADLDQAL 385
>sp|P66876|METB_MYCBO Cystathionine gamma-synthase (CGS) (O-succinylhomoserine
(Thiol)-lyase)
sp|P66875|METB_MYCTU Cystathionine gamma-synthase (CGS) (O-succinylhomoserine
(Thiol)-lyase)
Length = 388
Score = 150 bits (380), Expect = 2e-36
Identities = 86/177 (48%), Positives = 107/177 (60%)
Frame = +2
Query: 2 SDVLMGAAAMNNEGLYESLRQQQLMVGAVPSPFDCYLALRGLRTLVVRMTQHQLNGLAVA 181
SDV+ GA N+E L E Q GAVP PFD YL +RGL+TLV+RM +H N AVA
Sbjct: 214 SDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVA 273
Query: 182 LFLADHPKIEKVLHPALFPSPQKEIIAKQMTGFSGMLSAYVKGSHEDIVDFMKNLKYFPI 361
FLADHP + VL+P L P EI A+QM GF GM+S ++ D + F +
Sbjct: 274 EFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFIL 333
Query: 362 AKSLGGFESLIEIPSLMTYTSVPLDKCVELGICDNLVRFSVGLEDIYSLLEDLDNGL 532
A+SLGG ESLIE PS MT+ S +L + D+LVR SVG+EDI LL DL+ L
Sbjct: 334 AESLGGVESLIEHPSAMTHASTAGS---QLEVPDDLVRLSVGIEDIADLLGDLEQAL 387
>sp|P56069|METB_HELPY Cystathionine gamma-synthase (CGS) (O-succinylhomoserine
(Thiol)-lyase)
Length = 380
Score = 147 bits (371), Expect = 2e-35
Identities = 83/180 (46%), Positives = 108/180 (60%)
Frame = +2
Query: 2 SDVLMGAAAMNNEGLYESLRQQQLMVGAVPSPFDCYLALRGLRTLVVRMTQHQLNGLAVA 181
SDV+ G NNE L + + Q +G V P D +L RG++TL +RM HQ N L VA
Sbjct: 201 SDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVA 260
Query: 182 LFLADHPKIEKVLHPALFPSPQKEIIAKQMTGFSGMLSAYVKGSHEDIVDFMKNLKYFPI 361
FL HPK+E+V +P L P E+ KQM GFSGMLS +K E V F+++LK F +
Sbjct: 261 EFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFTLKNDSE-AVAFVESLKLFIL 319
Query: 362 AKSLGGFESLIEIPSLMTYTSVPLDKCVELGICDNLVRFSVGLEDIYSLLEDLDNGLTKI 541
+SLGG ESL+ IP+ MT+ +P + GI D LVR SVG+E LLEDL+ KI
Sbjct: 320 GESLGGVESLVGIPAFMTHACIPKTQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 379
>sp|P46807|METB_MYCLE Cystathionine gamma-synthase (CGS) (O-succinylhomoserine
(Thiol)-lyase)
Length = 388
Score = 145 bits (365), Expect = 1e-34
Identities = 83/177 (46%), Positives = 107/177 (60%)
Frame = +2
Query: 2 SDVLMGAAAMNNEGLYESLRQQQLMVGAVPSPFDCYLALRGLRTLVVRMTQHQLNGLAVA 181
SDV+ GA N+E L ++ Q GAVPSPFD YL +RGL+TLV+RM +H N + VA
Sbjct: 214 SDVVGGALVTNDEELDQAFGFLQNGAGAVPSPFDAYLTMRGLKTLVLRMQRHNENAITVA 273
Query: 182 LFLADHPKIEKVLHPALFPSPQKEIIAKQMTGFSGMLSAYVKGSHEDIVDFMKNLKYFPI 361
FLA HP + VL+P L P E+ A+QM GF GM+S ++ D K F +
Sbjct: 274 EFLAGHPSVSAVLYPGLPSHPGHEVAARQMRGFGGMVSLRMRAGRLAAQDLCARTKVFTL 333
Query: 362 AKSLGGFESLIEIPSLMTYTSVPLDKCVELGICDNLVRFSVGLEDIYSLLEDLDNGL 532
A+SLGG ESLIE PS MT+ S +L + D+LVR SVG+ED+ LL DL L
Sbjct: 334 AESLGGVESLIEQPSAMTHASTTGS---QLEVPDDLVRLSVGIEDVGDLLCDLKQAL 387
>sp|Q9ZMW7|METB_HELPJ Cystathionine gamma-synthase (CGS) (O-succinylhomoserine
(Thiol)-lyase)
Length = 380
Score = 141 bits (356), Expect = 1e-33
Identities = 82/180 (45%), Positives = 105/180 (58%)
Frame = +2
Query: 2 SDVLMGAAAMNNEGLYESLRQQQLMVGAVPSPFDCYLALRGLRTLVVRMTQHQLNGLAVA 181
SDV+ G NNE L + Q +G V D +L RG++TL +RM HQ N L VA
Sbjct: 201 SDVVAGLVTTNNEALAQEFDFFQNAIGGVLGLQDSWLLQRGIKTLGLRMEAHQKNALCVA 260
Query: 182 LFLADHPKIEKVLHPALFPSPQKEIIAKQMTGFSGMLSAYVKGSHEDIVDFMKNLKYFPI 361
FL HPK+E+V +P L P E+ QM GFSGM S +K E V F+++LK F +
Sbjct: 261 EFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMFSFTLKNDSE-AVAFVESLKLFIL 319
Query: 362 AKSLGGFESLIEIPSLMTYTSVPLDKCVELGICDNLVRFSVGLEDIYSLLEDLDNGLTKI 541
+SLGG ESL+ IP+LMT+ +P + GI D LVR SVG+E LLEDLD KI
Sbjct: 320 GESLGGVESLVGIPALMTHACIPKAQREAAGIRDGLVRLSVGIEHEQDLLEDLDQAFAKI 379
>sp|P0A4K3|METC_LACLC Cystathionine beta-lyase (CBL) (Beta-cystathionase) (Cysteine
lyase)
sp|P0A4K2|METC_LACLA Cystathionine beta-lyase (CBL) (Beta-cystathionase) (Cysteine
lyase)
Length = 380
Score = 136 bits (343), Expect = 4e-32
Identities = 75/179 (41%), Positives = 106/179 (59%)
Frame = +2
Query: 2 SDVLMGAAAMNNEGLYESLRQQQLMVGAVPSPFDCYLALRGLRTLVVRMTQHQLNGLAVA 181
SDV+ G N++ L + Q +GAV P D +L RG++TL +RM H N +A
Sbjct: 202 SDVVAGLVTTNSKELASEIGFLQNSIGAVLGPQDSWLVQRGIKTLALRMEAHSANAQKIA 261
Query: 182 LFLADHPKIEKVLHPALFPSPQKEIIAKQMTGFSGMLSAYVKGSHEDIVDFMKNLKYFPI 361
FL + KV +P L P EI KQM+ F GM+S + + + DF++NL YF +
Sbjct: 262 EFLETSKAVSKVYYPGLNSHPGHEIAKKQMSAFGGMISFELTDENA-VKDFVENLSYFTL 320
Query: 362 AKSLGGFESLIEIPSLMTYTSVPLDKCVELGICDNLVRFSVGLEDIYSLLEDLDNGLTK 538
A+SLGG ESLIE+P++MT+ S+P + E+GI D L+R SVG+E I LL D+ L K
Sbjct: 321 AESLGGVESLIEVPAVMTHASIPKELREEIGIKDGLIRLSVGVEAIEDLLTDIKEALEK 379
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,720,624
Number of Sequences: 369166
Number of extensions: 1387752
Number of successful extensions: 3406
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3307
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3383
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5413810770
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)