Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_E06
(747 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 235 8e-62
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 235 1e-61
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 232 7e-61
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 230 3e-60
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 226 5e-59
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 219 5e-57
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 219 8e-57
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 218 1e-56
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 218 2e-56
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 216 5e-56
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 235 bits (600), Expect = 8e-62
Identities = 123/248 (49%), Positives = 159/248 (64%), Gaps = 1/248 (0%)
Frame = +2
Query: 2 TAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHT 181
+AVP KF N L+ +W +K T R Y + RR +WE+N+K I+ HN EY GKH
Sbjct: 16 SAVP-KFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHG 72
Query: 182 YSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVK 361
+++ +N F DMTNEEF+ + +G + + +G + P + LP SVDWR+KGYVTPVK
Sbjct: 73 FTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVK 130
Query: 362 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 541
NQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS M AF+Y+
Sbjct: 131 NQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYV 190
Query: 542 KDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAI 718
K+ G++SE YPY A D CK P V TGFT + E L AVATVGP+SVA+
Sbjct: 191 KENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAM 250
Query: 719 DAGHASFQ 742
DAGH+SFQ
Sbjct: 251 DAGHSSFQ 258
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 235 bits (599), Expect = 1e-61
Identities = 123/235 (52%), Positives = 150/235 (63%), Gaps = 1/235 (0%)
Frame = +2
Query: 38 LNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMT 217
L +W +K R Y + RR +WE+N+K I+ HN EY GKH++++ +N F DMT
Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84
Query: 218 NEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFS 397
+EEF+ G KP +G + P P SVDWR+KGYVTPVKNQ QCGSCW+FS
Sbjct: 85 SEEFRQVMNGFQNRKPR-KGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFS 142
Query: 398 ATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDY 574
ATG+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y++D G++SE Y
Sbjct: 143 ATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESY 202
Query: 575 PYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 739
PY AT+ +CK NP V TGF DI Q E L AVATVGP+SVAIDAGH SF
Sbjct: 203 PYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESF 256
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 232 bits (592), Expect = 7e-61
Identities = 122/240 (50%), Positives = 149/240 (62%), Gaps = 2/240 (0%)
Frame = +2
Query: 29 NSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFA 208
+ LN +W +K T R Y + RR +WE+N+K I+ HN EY GKH +++ +N F
Sbjct: 22 DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFG 81
Query: 209 DMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCW 388
DMTNEEF+ G K +G + P +P SVDWR+KGYVTPVKNQ QCGSCW
Sbjct: 82 DMTNEEFRQVMNGFQNQKHK-KGKMFQEPL-FAEIPKSVDWREKGYVTPVKNQGQCGSCW 139
Query: 389 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESE 565
+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAFRY+KD G++SE
Sbjct: 140 AFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSE 199
Query: 566 GDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 742
YPY D TC P TGF D+ Q E L AVAT+GP+SVAIDAGH SFQ
Sbjct: 200 ESYPYLGRDTETCNYKPECSAANDTGFVDL-PQREKALMKAVATLGPISVAIDAGHQSFQ 258
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 230 bits (586), Expect = 3e-60
Identities = 124/241 (51%), Positives = 148/241 (61%), Gaps = 2/241 (0%)
Frame = +2
Query: 26 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 205
++ L+ W +K T R Y + RR +WE+N K I HN EY GKH + + +N F
Sbjct: 21 LDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHAFRMAMNAF 80
Query: 206 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 385
DMTNEEF+ G K +G + P + V P SVDW +KGYVTPVKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKLFHEPLLVDV-PKSVDWTKKGYVTPVKNQGQCGSC 138
Query: 386 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIES 562
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+YIKD G++S
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDS 198
Query: 563 EGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 739
E YPY ATD +C P TGF DI Q E L AVATVGP+SVAIDAGH SF
Sbjct: 199 EESYPYLATDTNSCNYKPECSAANDTGFVDI-PQREKALMKAVATVGPISVAIDAGHTSF 257
Query: 740 Q 742
Q
Sbjct: 258 Q 258
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 226 bits (576), Expect = 5e-59
Identities = 120/241 (49%), Positives = 151/241 (62%), Gaps = 2/241 (0%)
Frame = +2
Query: 26 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 205
++ L+ +W +K T GR Y + RR +WE+N+K I+ HN EY GKH +S+ +N F
Sbjct: 21 LDQNLDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGFSMAMNAF 80
Query: 206 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 385
DMTNEEF+ G K +G + + V P SVDWR+KGYVT VKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKVFHESLVLEV-PKSVDWREKGYVTAVKNQGQCGSC 138
Query: 386 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIES 562
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+Y+KD G+++
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDT 198
Query: 563 EGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 739
E YPY + +C P TGF DI Q E L AVATVGP+SVAIDAGH+SF
Sbjct: 199 EESYPYLGRETNSCTYKPECSAANDTGFVDI-PQREKALMKAVATVGPISVAIDAGHSSF 257
Query: 740 Q 742
Q
Sbjct: 258 Q 258
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 219 bits (559), Expect = 5e-57
Identities = 106/224 (47%), Positives = 140/224 (62%)
Frame = +2
Query: 50 WETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEF 229
W +K + ++Y+ D RR IWE+N+K+IQ+HNL +DLG TY+LGLNQF DMT EEF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 230 KAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGS 409
KAKYL M + N +P +DWR+ GYVT VK+Q CGSCW+FS TG+
Sbjct: 81 KAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGT 140
Query: 410 LEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQGIESEGDYPYTAT 589
+EGQY + ISFSEQQLVDCS LM+NA++Y+K G+E+E YPYTA
Sbjct: 141 MEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAV 200
Query: 590 DGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAID 721
+G C+ N V K TG+ + S +E +L N V P +VA+D
Sbjct: 201 EGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVD 244
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 219 bits (557), Expect = 8e-57
Identities = 119/233 (51%), Positives = 145/233 (62%), Gaps = 1/233 (0%)
Frame = +2
Query: 47 EWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEE 226
EW +K+T R Y + RR IWE+N++ IQ HN EY G+H +S+ +N F DMTNEE
Sbjct: 28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEE 87
Query: 227 FKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATG 406
F+ G K +G + P + + P SVDWR+KG VTPVKNQ QCGSCW+FSA+G
Sbjct: 88 FRQVVNGYRHQKHK-KGRLFQEPLMLKI-PKSVDWREKGCVTPVKNQGQCGSCWAFSASG 145
Query: 407 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYT 583
LEGQ F K +LIS SEQ LVDCS LMD AF+YIK+ G++SE YPY
Sbjct: 146 CLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYE 205
Query: 584 ATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 742
A DG+CK V TGF DI Q E L AVATVGP+SVA+DA H S Q
Sbjct: 206 AKDGSCKYRAEFAVANDTGFVDI-PQQEKALMKAVATVGPISVAMDASHPSLQ 257
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 218 bits (556), Expect = 1e-56
Identities = 117/235 (49%), Positives = 146/235 (62%), Gaps = 1/235 (0%)
Frame = +2
Query: 41 NEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTN 220
N +W +K+T R Y + RR +WE+N++ IQ HN EY GKH +++ +N F DMTN
Sbjct: 26 NAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTN 85
Query: 221 EEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSA 400
EEF+ G K +G + P + + P +VDWR+KG VTPVKNQ QCGSCW+FSA
Sbjct: 86 EEFRQIVNGYRHQKHK-KGRLFQEPLMLQI-PKTVDWREKGCVTPVKNQGQCGSCWAFSA 143
Query: 401 TGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYP 577
+G LEGQ F K +LIS SEQ LVDCS LMD AF+YIK+ G++SE YP
Sbjct: 144 SGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYP 203
Query: 578 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 742
Y A DG+CK V TGF DI Q E L AVATVGP+SVA+DA H S Q
Sbjct: 204 YEAKDGSCKYRAEYAVANDTGFVDI-PQQEKALMKAVATVGPISVAMDASHPSLQ 257
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 218 bits (554), Expect = 2e-56
Identities = 122/256 (47%), Positives = 156/256 (60%), Gaps = 9/256 (3%)
Frame = +2
Query: 5 AVPQKFSVNSELNEEWETYKTTFGRKY-DELTDITRRLIWEQNLKYIQKHNLEYDLGKHT 181
A+ Q S + EEW TYK + Y +E+ + R I+ +N I KHN + GK +
Sbjct: 13 ALTQAISPLDLIKEEWHTYKLQHRKNYANEVEERFRMKIFNENRHKIAKHNQLFAQGKVS 72
Query: 182 YSLGLNQFADMTNEEFKAKYLG-------IMKTKPTLEGSTYMAPENIGVLPASVDWRQK 340
Y LGLN++ADM + EFK G +M+ + L G+TY+ P ++ V P SVDWR+
Sbjct: 73 YKLGLNKYADMLHHEFKETMNGYNHTLRQLMRERTGLVGATYIPPAHVTV-PKSVDWREH 131
Query: 341 GYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLM 520
G VT VK+Q CGSCW+FS+TG+LEGQ+FRK L+S SEQ LVDCS LM
Sbjct: 132 GAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLM 191
Query: 521 DNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATV 697
DNAFRYIKD GI++E YPY D +C N + I TGF DI +E + AVAT+
Sbjct: 192 DNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATM 251
Query: 698 GPVSVAIDAGHASFQL 745
GPVSVAIDA H SFQL
Sbjct: 252 GPVSVAIDASHESFQL 267
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 216 bits (550), Expect = 5e-56
Identities = 116/239 (48%), Positives = 151/239 (63%), Gaps = 4/239 (1%)
Frame = +2
Query: 38 LNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADM 214
L+ +WE +K T+ ++Y+ D I+RRLIWE+NLK+I HNLE LG HTY L +N DM
Sbjct: 22 LDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDM 81
Query: 215 TNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCW 388
T+EE K G+ K P+ S T P+ G P S+D+R+KGYVTPVKNQ QCGSCW
Sbjct: 82 TSEEVVQKMTGL-KVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCW 140
Query: 389 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI-KDQGIESE 565
+FS+ G+LEGQ +K +L++ S Q LVDC M NAF+Y+ +++GI+SE
Sbjct: 141 AFSSVGALEGQLKKKTGKLLNLSPQNLVDC--VSENYGCGGGYMTNAFQYVQRNRGIDSE 198
Query: 566 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 742
YPY D +C NP+ KC G+ +I NE L AVA VGPVSVAIDA SFQ
Sbjct: 199 DAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,577,201
Number of Sequences: 369166
Number of extensions: 1552430
Number of successful extensions: 4540
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4091
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4208
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6776504000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)