Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_D06
(809 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P29678|MP2K1_RABIT Dual specificity mitogen-activated pr... 207 3e-53
sp|Q01986|MP2K1_RAT Dual specificity mitogen-activated prot... 207 4e-53
sp|Q02750|MP2K1_HUMAN Dual specificity mitogen-activated pr... 207 4e-53
sp|P31938|MP2K1_MOUSE Dual specificity mitogen-activated pr... 206 5e-53
sp|P36506|MP2K2_RAT Dual specificity mitogen-activated prot... 206 8e-53
sp|Q63932|MP2K2_MOUSE Dual specificity mitogen-activated pr... 206 8e-53
sp|Q63980|MP2K1_CRIGR Dual specificity mitogen-activated pr... 204 2e-52
sp|Q90891|MP2K2_CHICK Dual specificity mitogen-activated pr... 204 2e-52
sp|Q90321|MP2K2_CYPCA Dual specificity mitogen-activated pr... 203 4e-52
sp|P36507|MP2K2_HUMAN Dual specificity mitogen-activated pr... 203 5e-52
>sp|P29678|MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 (MAP
kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)
(MAPK/ERK kinase 1) (MEK1)
Length = 393
Score = 207 bits (527), Expect = 3e-53
Identities = 106/197 (53%), Positives = 139/197 (70%), Gaps = 1/197 (0%)
Frame = +1
Query: 1 ITISVVNGLLYLREELDIIHRDVKPSNILVNSDGEVKLCDFGVSGQLIDSMANSFVGTRS 180
++I+V+ GL YLRE+ I+HRDVKPSNILVNS GE+KLCDFGVSGQLIDSMANSFVGTRS
Sbjct: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS 228
Query: 181 YMAPERLIGEEYNVRSDVWSLGLSLIELATGRYPIPPAKEEDFHSTFSQDRQVNLAEHLD 360
YM+PERL G Y+V+SD+WS+GLSL+E+A GRYPIPP ++ F + + AE
Sbjct: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288
Query: 361 -AALHGKKLKAMQVSDSNNMAIFELLAYIVDYPPPRVPEFCFSNDFITFVHSCLQENASD 537
G+ L + + MAIFELL YIV+ PPP++P FS +F FV+ CL +N ++
Sbjct: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAE 348
Query: 538 RPRLESLLTYNFLLNPD 588
R L+ L+ + F+ D
Sbjct: 349 RADLKQLMVHAFIKRSD 365
>sp|Q01986|MP2K1_RAT Dual specificity mitogen-activated protein kinase kinase 1 (MAP
kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)
(MAPK/ERK kinase 1) (MEK1)
Length = 393
Score = 207 bits (526), Expect = 4e-53
Identities = 106/197 (53%), Positives = 139/197 (70%), Gaps = 1/197 (0%)
Frame = +1
Query: 1 ITISVVNGLLYLREELDIIHRDVKPSNILVNSDGEVKLCDFGVSGQLIDSMANSFVGTRS 180
++I+V+ GL YLRE+ I+HRDVKPSNILVNS GE+KLCDFGVSGQLIDSMANSFVGTRS
Sbjct: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS 228
Query: 181 YMAPERLIGEEYNVRSDVWSLGLSLIELATGRYPIPPAKEEDFHSTFSQDRQVNLAEHLD 360
YM+PERL G Y+V+SD+WS+GLSL+E+A GRYPIPP ++ F + + AE
Sbjct: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPP 288
Query: 361 -AALHGKKLKAMQVSDSNNMAIFELLAYIVDYPPPRVPEFCFSNDFITFVHSCLQENASD 537
G+ L + + MAIFELL YIV+ PPP++P FS +F FV+ CL +N ++
Sbjct: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348
Query: 538 RPRLESLLTYNFLLNPD 588
R L+ L+ + F+ D
Sbjct: 349 RADLKQLMVHAFIKRSD 365
>sp|Q02750|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (MAP
kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)
(MAPK/ERK kinase 1) (MEK1)
Length = 393
Score = 207 bits (526), Expect = 4e-53
Identities = 106/197 (53%), Positives = 139/197 (70%), Gaps = 1/197 (0%)
Frame = +1
Query: 1 ITISVVNGLLYLREELDIIHRDVKPSNILVNSDGEVKLCDFGVSGQLIDSMANSFVGTRS 180
++I+V+ GL YLRE+ I+HRDVKPSNILVNS GE+KLCDFGVSGQLIDSMANSFVGTRS
Sbjct: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS 228
Query: 181 YMAPERLIGEEYNVRSDVWSLGLSLIELATGRYPIPPAKEEDFHSTFSQDRQVNLAEHLD 360
YM+PERL G Y+V+SD+WS+GLSL+E+A GRYPIPP ++ F + + AE
Sbjct: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288
Query: 361 -AALHGKKLKAMQVSDSNNMAIFELLAYIVDYPPPRVPEFCFSNDFITFVHSCLQENASD 537
G+ L + + MAIFELL YIV+ PPP++P FS +F FV+ CL +N ++
Sbjct: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348
Query: 538 RPRLESLLTYNFLLNPD 588
R L+ L+ + F+ D
Sbjct: 349 RADLKQLMVHAFIKRSD 365
>sp|P31938|MP2K1_MOUSE Dual specificity mitogen-activated protein kinase kinase 1 (MAP
kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)
(MAPK/ERK kinase 1) (MEK1)
Length = 393
Score = 206 bits (525), Expect = 5e-53
Identities = 106/197 (53%), Positives = 139/197 (70%), Gaps = 1/197 (0%)
Frame = +1
Query: 1 ITISVVNGLLYLREELDIIHRDVKPSNILVNSDGEVKLCDFGVSGQLIDSMANSFVGTRS 180
++I+V+ GL YLRE+ I+HRDVKPSNILVNS GE+KLCDFGVSGQLIDSMANSFVGTRS
Sbjct: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS 228
Query: 181 YMAPERLIGEEYNVRSDVWSLGLSLIELATGRYPIPPAKEEDFHSTFSQDRQVNLAEHLD 360
YM+PERL G Y+V+SD+WS+GLSL+E+A GRYPIPP ++ F + + AE
Sbjct: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPP 288
Query: 361 -AALHGKKLKAMQVSDSNNMAIFELLAYIVDYPPPRVPEFCFSNDFITFVHSCLQENASD 537
G+ L + + MAIFELL YIV+ PPP++P FS +F FV+ CL +N ++
Sbjct: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348
Query: 538 RPRLESLLTYNFLLNPD 588
R L+ L+ + F+ D
Sbjct: 349 RADLKQLMVHAFIKRSD 365
>sp|P36506|MP2K2_RAT Dual specificity mitogen-activated protein kinase kinase 2 (MAP
kinase kinase 2) (MAPKK 2) (ERK activator kinase 2)
(MAPK/ERK kinase 2) (MEK2)
Length = 400
Score = 206 bits (523), Expect = 8e-53
Identities = 106/201 (52%), Positives = 140/201 (69%), Gaps = 9/201 (4%)
Frame = +1
Query: 1 ITISVVNGLLYLREELDIIHRDVKPSNILVNSDGEVKLCDFGVSGQLIDSMANSFVGTRS 180
++I+V+ GL YLRE+ I+HRDVKPSNILVNS GE+KLCDFGVSGQLIDSMANSFVGTRS
Sbjct: 173 VSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS 232
Query: 181 YMAPERLIGEEYNVRSDVWSLGLSLIELATGRYPIPPAKEEDFHSTFSQDRQVNLAEHLD 360
YM+PERL G Y+V+SD+WS+GLSL+ELA GRYPIPP ++ ++F + + + D
Sbjct: 233 YMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRP----VVDGAD 288
Query: 361 AALH---------GKKLKAMQVSDSNNMAIFELLAYIVDYPPPRVPEFCFSNDFITFVHS 513
H G+ + + MAIFELL YIV+ PPP++P FS+DF FV+
Sbjct: 289 GEPHSVSPRPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNK 348
Query: 514 CLQENASDRPRLESLLTYNFL 576
CL +N ++R L+ L + F+
Sbjct: 349 CLIKNPAERADLKLLTNHAFI 369
>sp|Q63932|MP2K2_MOUSE Dual specificity mitogen-activated protein kinase kinase 2 (MAP
kinase kinase 2) (MAPKK 2) (ERK activator kinase 2)
(MAPK/ERK kinase 2) (MEK2)
Length = 401
Score = 206 bits (523), Expect = 8e-53
Identities = 108/202 (53%), Positives = 142/202 (70%), Gaps = 10/202 (4%)
Frame = +1
Query: 1 ITISVVNGLLYLREELDIIHRDVKPSNILVNSDGEVKLCDFGVSGQLIDSMANSFVGTRS 180
++I+V+ GL YLRE+ I+HRDVKPSNILVNS GE+KLCDFGVSGQLIDSMANSFVGTRS
Sbjct: 173 VSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS 232
Query: 181 YMAPERLIGEEYNVRSDVWSLGLSLIELATGRYPIPPAKEEDFHSTFSQDRQVNLAEHLD 360
YM+PERL G Y+V+SD+WS+GLSL+ELA GRYPIPP ++ ++F + + + D
Sbjct: 233 YMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRP----VVDGAD 288
Query: 361 AALH---------GKKLKAMQVSDSN-NMAIFELLAYIVDYPPPRVPEFCFSNDFITFVH 510
H G+ + DS MAIFELL YIV+ PPP++P FS+DF FV+
Sbjct: 289 GEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVN 348
Query: 511 SCLQENASDRPRLESLLTYNFL 576
CL +N ++R L+ L+ + F+
Sbjct: 349 KCLIKNPAERADLKLLMNHAFI 370
>sp|Q63980|MP2K1_CRIGR Dual specificity mitogen-activated protein kinase kinase 1 (MAP
kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)
(MAPK/ERK kinase 1) (MEK1)
Length = 393
Score = 204 bits (520), Expect = 2e-52
Identities = 106/197 (53%), Positives = 138/197 (70%), Gaps = 1/197 (0%)
Frame = +1
Query: 1 ITISVVNGLLYLREELDIIHRDVKPSNILVNSDGEVKLCDFGVSGQLIDSMANSFVGTRS 180
++I+V+ GL YLRE+ I+HRDVKPSNILVNS GE+KLCDFGVSGQLIDSMANSFVGTRS
Sbjct: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS 228
Query: 181 YMAPERLIGEEYNVRSDVWSLGLSLIELATGRYPIPPAKEEDFHSTFSQDRQVNLAEHLD 360
YM+PERL G Y+V+SD+WS+GLSL+E+A GRYPIPP ++ F + + AE
Sbjct: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPP 288
Query: 361 -AALHGKKLKAMQVSDSNNMAIFELLAYIVDYPPPRVPEFCFSNDFITFVHSCLQENASD 537
G+ L + + MAIFELL YIV+ PP ++P FS +F FV+ CL +N ++
Sbjct: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPAKLPSGVFSLEFQDFVNKCLIKNPAE 348
Query: 538 RPRLESLLTYNFLLNPD 588
R L+ LL + F+ D
Sbjct: 349 RADLKQLLVHAFIKRSD 365
>sp|Q90891|MP2K2_CHICK Dual specificity mitogen-activated protein kinase kinase 2 (MAP
kinase kinase 2) (MAPKK 2) (ERK activator kinase 2)
(MAPK/ERK kinase 2) (MEK2)
Length = 398
Score = 204 bits (519), Expect = 2e-52
Identities = 105/198 (53%), Positives = 141/198 (71%), Gaps = 6/198 (3%)
Frame = +1
Query: 1 ITISVVNGLLYLREELDIIHRDVKPSNILVNSDGEVKLCDFGVSGQLIDSMANSFVGTRS 180
++I+V+ GL YLRE+ I+HRDVKPSNILVNS GE+KLCDFGVSGQLIDSMANSFVGTRS
Sbjct: 171 VSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS 230
Query: 181 YMAPERLIGEEYNVRSDVWSLGLSLIELATGRYPIPPAKEEDFHSTFSQDRQVNLAEHLD 360
YM+PERL G Y+V+SD+WS+GLSL+EL+ GRYPIPP ++ + F + V+ AE
Sbjct: 231 YMSPERLQGTHYSVQSDIWSMGLSLVELSIGRYPIPPPDSKELEAIFGRP-VVDGAEGES 289
Query: 361 AALH------GKKLKAMQVSDSNNMAIFELLAYIVDYPPPRVPEFCFSNDFITFVHSCLQ 522
++ G+ + + MAIFELL YIV+ PPP++P F+ DF FV+ CL
Sbjct: 290 HSVSPWARPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLI 349
Query: 523 ENASDRPRLESLLTYNFL 576
+N ++R L+ L+ + F+
Sbjct: 350 KNPAERADLKMLMNHTFI 367
>sp|Q90321|MP2K2_CYPCA Dual specificity mitogen-activated protein kinase kinase 2 (MAP
kinase kinase 2) (MAPKK 2) (ERK activator kinase 2)
(MAPK/ERK kinase 2) (MEK2)
Length = 397
Score = 203 bits (517), Expect = 4e-52
Identities = 105/197 (53%), Positives = 138/197 (70%), Gaps = 5/197 (2%)
Frame = +1
Query: 1 ITISVVNGLLYLREELDIIHRDVKPSNILVNSDGEVKLCDFGVSGQLIDSMANSFVGTRS 180
++I+V+ GL+YLRE+ I+HRDVKPSNILVNS GE+KLCDFGVSGQLIDSMANSFVGTRS
Sbjct: 170 VSIAVLRGLVYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS 229
Query: 181 YMAPERLIGEEYNVRSDVWSLGLSLIELATGRYPIPPAKEEDFHSTFSQ---DRQVNLAE 351
YM+PERL G Y+V+SDVWS+GLSL+ELA GR+PIPP ++ + F + D+
Sbjct: 230 YMSPERLQGTHYSVQSDVWSMGLSLVELAIGRFPIPPPDAKELEAIFGRPVLDKGGAEGH 289
Query: 352 HLDAALH--GKKLKAMQVSDSNNMAIFELLAYIVDYPPPRVPEFCFSNDFITFVHSCLQE 525
+ G+ + + MAIFELL YIV+ PPP++P F+ DF FV CL +
Sbjct: 290 SMSPRQRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPHGVFTTDFEEFVMKCLMK 349
Query: 526 NASDRPRLESLLTYNFL 576
N +DR L+ L+ + F+
Sbjct: 350 NPADRADLKMLMGHTFI 366
>sp|P36507|MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase 2 (MAP
kinase kinase 2) (MAPKK 2) (ERK activator kinase 2)
(MAPK/ERK kinase 2) (MEK2)
Length = 400
Score = 203 bits (516), Expect = 5e-52
Identities = 105/197 (53%), Positives = 137/197 (69%), Gaps = 5/197 (2%)
Frame = +1
Query: 1 ITISVVNGLLYLREELDIIHRDVKPSNILVNSDGEVKLCDFGVSGQLIDSMANSFVGTRS 180
++I+V+ GL YLRE+ I+HRDVKPSNILVNS GE+KLCDFGVSGQLIDSMANSFVGTRS
Sbjct: 173 VSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS 232
Query: 181 YMAPERLIGEEYNVRSDVWSLGLSLIELATGRYPIPPAKEEDFHSTFSQ---DRQVNLAE 351
YMAPERL G Y+V+SD+WS+GLSL+ELA GRYPIPP ++ + F + D +
Sbjct: 233 YMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPH 292
Query: 352 HLDAALH--GKKLKAMQVSDSNNMAIFELLAYIVDYPPPRVPEFCFSNDFITFVHSCLQE 525
+ G+ + + MAIFELL YIV+ PPP++P F+ DF FV+ CL +
Sbjct: 293 SISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIK 352
Query: 526 NASDRPRLESLLTYNFL 576
N ++R L+ L + F+
Sbjct: 353 NPAERADLKMLTNHTFI 369
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,104,899
Number of Sequences: 369166
Number of extensions: 1719593
Number of successful extensions: 7890
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5975
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6350
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)