Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_B14
(867 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9BUN8|DERL1_HUMAN Derlin-1 (Degradation in endoplasmic ... 301 2e-81
sp|Q5R9W3|DERL1_PONPY Derlin-1 (Degradation in endoplasmic ... 301 2e-81
sp|Q71SS4|DERL1_BOVIN Derlin-1 (Degradation in endoplasmic ... 300 3e-81
sp|Q99J56|DERL1_MOUSE Derlin-1 (Degradation in endoplasmic ... 296 4e-80
sp|Q93561|DERL1_CAEEL Derlin-1 (DER1-like protein 1) (cDerl... 239 9e-63
sp|Q9VQ57|DERL1_DROME Derlin-1 (DER1-like protein 1) 203 4e-52
sp|Q9D8K3|DERL3_MOUSE Derlin-3 (Degradation in endoplasmic ... 124 3e-28
sp|Q5RC74|DERL2_PONPY Derlin-2 (Degradation in endoplasmic ... 121 3e-27
sp|Q8BNI4|DERL2_MOUSE Derlin-2 (Degradation in endoplasmic ... 120 4e-27
sp|Q96Q80|DERL3_HUMAN Derlin-3 (Degradation in endoplasmic ... 119 1e-26
>sp|Q9BUN8|DERL1_HUMAN Derlin-1 (Degradation in endoplasmic reticulum protein 1)
(Der1-like protein 1) (DERtrin-1)
Length = 251
Score = 301 bits (771), Expect = 2e-81
Identities = 135/249 (54%), Positives = 177/249 (71%)
Frame = +1
Query: 73 NDIGDWYRSIPIVSKYWFSGSIIFPLIGKLGLVDPYKMVLMWAPFIEKFQIWRPITALLY 252
+DIGDW+RSIP +++YWF+ ++ PL+GKLGL+ P + L F+ +FQIWRPITA Y
Sbjct: 2 SDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATFY 61
Query: 253 YPISPVSGFHXXXXXXXXXXXXTRLETGTFSGKPADYLFMLIFNWLCLVVIGFIAPLYLL 432
+P+ P +GF TRLETG F G+PADYLFML+FNW+C+V+ G + LL
Sbjct: 62 FPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQLL 121
Query: 433 MDPMIISVLYVWCQLNKDVIVQFWFGTQFKAMYLPWILLGFNMIISGGGFSDLLGIVVGH 612
M P+I+SVLYVW QLN+D+IV FWFGT+FKA YLPW++LGFN II G ++L+G +VGH
Sbjct: 122 MIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGH 181
Query: 613 LYFFLMFKYPQEFGGNVWLRTPQFLYKWLPNTVGGVSGFGMAPSSRIARGDTSSNSRPRF 792
LYFFLMF+YP + GG +L TPQFLY+WLP+ GGVSGFG+ P+S D +
Sbjct: 182 LYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHN 241
Query: 793 PGRGQTLGD 819
G+G LGD
Sbjct: 242 WGQGFRLGD 250
>sp|Q5R9W3|DERL1_PONPY Derlin-1 (Degradation in endoplasmic reticulum protein 1)
(Der1-like protein 1)
Length = 251
Score = 301 bits (771), Expect = 2e-81
Identities = 135/249 (54%), Positives = 177/249 (71%)
Frame = +1
Query: 73 NDIGDWYRSIPIVSKYWFSGSIIFPLIGKLGLVDPYKMVLMWAPFIEKFQIWRPITALLY 252
+DIGDW+RSIP +++YWF+ ++ PL+GKLGL+ P + L F+ +FQIWRPITA Y
Sbjct: 2 SDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATFY 61
Query: 253 YPISPVSGFHXXXXXXXXXXXXTRLETGTFSGKPADYLFMLIFNWLCLVVIGFIAPLYLL 432
+P+ P +GF TRLETG F G+PADYLFML+FNW+C+V+ G + LL
Sbjct: 62 FPVGPGTGFLYLVNLYFLYHYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQLL 121
Query: 433 MDPMIISVLYVWCQLNKDVIVQFWFGTQFKAMYLPWILLGFNMIISGGGFSDLLGIVVGH 612
M P+I+SVLYVW QLN+D+IV FWFGT+FKA YLPW++LGFN II G ++L+G +VGH
Sbjct: 122 MIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGH 181
Query: 613 LYFFLMFKYPQEFGGNVWLRTPQFLYKWLPNTVGGVSGFGMAPSSRIARGDTSSNSRPRF 792
LYFFLMF+YP + GG +L TPQFLY+WLP+ GGVSGFG+ P+S D +
Sbjct: 182 LYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHN 241
Query: 793 PGRGQTLGD 819
G+G LGD
Sbjct: 242 WGQGFRLGD 250
>sp|Q71SS4|DERL1_BOVIN Derlin-1 (Degradation in endoplasmic reticulum protein 1)
(Der1-like protein 1)
Length = 251
Score = 300 bits (769), Expect = 3e-81
Identities = 135/249 (54%), Positives = 176/249 (70%)
Frame = +1
Query: 73 NDIGDWYRSIPIVSKYWFSGSIIFPLIGKLGLVDPYKMVLMWAPFIEKFQIWRPITALLY 252
+DIGDW+RSIP +++YWF+ ++ PL+GKLGL+ P L F+ +FQIWRPITA Y
Sbjct: 2 SDIGDWFRSIPTITRYWFAATVAVPLVGKLGLISPAYFFLWPEAFLYRFQIWRPITATFY 61
Query: 253 YPISPVSGFHXXXXXXXXXXXXTRLETGTFSGKPADYLFMLIFNWLCLVVIGFIAPLYLL 432
+P+ P +GF TRLETG F G+PADYLFML+FNW+C+V+ G + LL
Sbjct: 62 FPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQLL 121
Query: 433 MDPMIISVLYVWCQLNKDVIVQFWFGTQFKAMYLPWILLGFNMIISGGGFSDLLGIVVGH 612
M P+I+SVLYVW QLN+D+IV FWFGT+FKA YLPW++LGFN II G ++L+G +VGH
Sbjct: 122 MIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGH 181
Query: 613 LYFFLMFKYPQEFGGNVWLRTPQFLYKWLPNTVGGVSGFGMAPSSRIARGDTSSNSRPRF 792
LYFFLMF+YP + GG +L TPQFLY+WLP+ GGVSGFG+ P+S D +
Sbjct: 182 LYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHN 241
Query: 793 PGRGQTLGD 819
G+G LGD
Sbjct: 242 WGQGFRLGD 250
>sp|Q99J56|DERL1_MOUSE Derlin-1 (Degradation in endoplasmic reticulum protein 1)
(Der1-like protein 1)
Length = 251
Score = 296 bits (759), Expect = 4e-80
Identities = 133/249 (53%), Positives = 174/249 (69%)
Frame = +1
Query: 73 NDIGDWYRSIPIVSKYWFSGSIIFPLIGKLGLVDPYKMVLMWAPFIEKFQIWRPITALLY 252
+DIGDW+RSIP +++YWF+ ++ PLIGKLG++ P L F+ +FQIWRP TA Y
Sbjct: 2 SDIGDWFRSIPAITRYWFAATVAVPLIGKLGIISPAYFFLWPEAFLYRFQIWRPFTATFY 61
Query: 253 YPISPVSGFHXXXXXXXXXXXXTRLETGTFSGKPADYLFMLIFNWLCLVVIGFIAPLYLL 432
+P+ P +GF TRLE G F G+PADYLFML+FNW+C+V+ G + LL
Sbjct: 62 FPVGPGTGFLYLVNLYFLYQYSTRLEAGAFDGRPADYLFMLLFNWICIVITGLAMDMQLL 121
Query: 433 MDPMIISVLYVWCQLNKDVIVQFWFGTQFKAMYLPWILLGFNMIISGGGFSDLLGIVVGH 612
M P+I+SVLYVW QLN+D+IV FWFGT+FKA YLPW++LGFN II G ++L+G +VGH
Sbjct: 122 MIPLIMSVLYVWAQLNRDLIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGH 181
Query: 613 LYFFLMFKYPQEFGGNVWLRTPQFLYKWLPNTVGGVSGFGMAPSSRIARGDTSSNSRPRF 792
LYFFLMF+YP + GG +L TPQFLY+WLP+ GGVSGFG+ P+S D +
Sbjct: 182 LYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHN 241
Query: 793 PGRGQTLGD 819
G+G LGD
Sbjct: 242 WGQGFRLGD 250
>sp|Q93561|DERL1_CAEEL Derlin-1 (DER1-like protein 1) (cDerlin-1)
Length = 245
Score = 239 bits (609), Expect = 9e-63
Identities = 105/217 (48%), Positives = 148/217 (68%)
Frame = +1
Query: 76 DIGDWYRSIPIVSKYWFSGSIIFPLIGKLGLVDPYKMVLMWAPFIEKFQIWRPITALLYY 255
D+ ++ IPIV++YWF S I PL+G+ G ++ M L W + KFQ WRP+TAL+YY
Sbjct: 2 DLENFLLGIPIVTRYWFLASTIIPLLGRFGFINVQWMFLQWDLVVNKFQFWRPLTALIYY 61
Query: 256 PISPVSGFHXXXXXXXXXXXXTRLETGTFSGKPADYLFMLIFNWLCLVVIGFIAPLYLLM 435
P++P +GFH LE+ T+ G+ ADYLFMLIFNW + +Y L+
Sbjct: 62 PVTPQTGFHWLMMCYFLYNYSKALESETYRGRSADYLFMLIFNWFFCSGLCMALDIYFLL 121
Query: 436 DPMIISVLYVWCQLNKDVIVQFWFGTQFKAMYLPWILLGFNMIISGGGFSDLLGIVVGHL 615
+PM+ISVLYVWCQ+NKD IV FWFG +F A YLPW+L GFN ++ GGG ++L+GI+VGH
Sbjct: 122 EPMVISVLYVWCQVNKDTIVSFWFGMRFPARYLPWVLWGFNAVLRGGGTNELVGILVGHA 181
Query: 616 YFFLMFKYPQEFGGNVWLRTPQFLYKWLPNTVGGVSG 726
YFF+ KYP E+G ++ + TP+FL++ +P+ GG+ G
Sbjct: 182 YFFVALKYPDEYGVDL-ISTPEFLHRLIPDEDGGIHG 217
>sp|Q9VQ57|DERL1_DROME Derlin-1 (DER1-like protein 1)
Length = 245
Score = 203 bits (517), Expect = 4e-52
Identities = 97/247 (39%), Positives = 146/247 (59%)
Frame = +1
Query: 76 DIGDWYRSIPIVSKYWFSGSIIFPLIGKLGLVDPYKMVLMWAPFIEKFQIWRPITALLYY 255
D G WYRS+P ++YW + +++ ++ + ++ + + L + K Q+WR +T+L +
Sbjct: 2 DAGVWYRSLPRFTRYWLTATVVLSMLCRFDVIPLHWLHLDRSAVFSKLQLWRCMTSLFVF 61
Query: 256 PISPVSGFHXXXXXXXXXXXXTRLETGTFSGKPADYLFMLIFNWLCLVVIGFIAPLYLLM 435
PIS + FH ++LE +S PADYL++LI + + + G I +Y LM
Sbjct: 62 PISSNTAFHFLINCFFIVQYSSKLEKDQYSRSPADYLYLLIVSAVLANIGGMIFNVYFLM 121
Query: 436 DPMIISVLYVWCQLNKDVIVQFWFGTQFKAMYLPWILLGFNMIISGGGFSDLLGIVVGHL 615
D +++++ Y+WCQLNKDV V FWFGT+FKAMYLPW+L F I + L+GI VGH+
Sbjct: 122 DTLVLAITYIWCQLNKDVTVSFWFGTRFKAMYLPWVLAAFEFIFH-FSLASLVGIFVGHV 180
Query: 616 YFFLMFKYPQEFGGNVWLRTPQFLYKWLPNTVGGVSGFGMAPSSRIARGDTSSNSRPRFP 795
Y+F F+Y Q+ GG L TPQFL + +P+ GG GFG+ P SR + +
Sbjct: 181 YYFFKFQYSQDLGGTPLLETPQFLKRLVPDVSGGFGGFGLPPESRAPPRQATESPW---- 236
Query: 796 GRGQTLG 816
GRG TLG
Sbjct: 237 GRGMTLG 243
>sp|Q9D8K3|DERL3_MOUSE Derlin-3 (Degradation in endoplasmic reticulum protein 3)
(Der1-like protein 3) (Protein IZP6)
Length = 228
Score = 124 bits (312), Expect = 3e-28
Identities = 64/208 (30%), Positives = 114/208 (54%)
Frame = +1
Query: 64 MSGNDIGDWYRSIPIVSKYWFSGSIIFPLIGKLGLVDPYKMVLMWAPFIEKFQIWRPITA 243
M+G + + +P V++ + + ++ +L L+ P+++ KFQ+WR IT
Sbjct: 1 MAGQRLAAGFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLITT 60
Query: 244 LLYYPISPVSGFHXXXXXXXXXXXXTRLETGTFSGKPADYLFMLIFNWLCLVVIGFIAPL 423
L++ P+ GF LE G+F G+ AD++FM +F + + ++GF+ L
Sbjct: 61 FLFF--GPL-GFGFFFNMLFVFRYCRMLEEGSFRGRKADFVFMFLFGGVLMTLLGFLGSL 117
Query: 424 YLLMDPMIISVLYVWCQLNKDVIVQFWFGTQFKAMYLPWILLGFNMIISGGGFSDLLGIV 603
+ L ++ ++YVW + + V V F+ F+A +LPW L+GF++++ +DLLGI+
Sbjct: 118 FFLGQALMAMLVYVWSRRSPHVRVNFFGLLNFQAPFLPWALMGFSLLLGNSVVTDLLGIL 177
Query: 604 VGHLYFFLMFKYPQEFGGNVWLRTPQFL 687
VGH+Y+FL +P + GG L TP L
Sbjct: 178 VGHIYYFLEDVFPNQPGGKRLLLTPSVL 205
>sp|Q5RC74|DERL2_PONPY Derlin-2 (Degradation in endoplasmic reticulum protein 2)
(Der1-like protein 2)
sp|Q9GZP9|DERL2_HUMAN Derlin-2 (Degradation in endoplasmic reticulum protein 2)
(Der1-like protein 2) (DERtrin-2) (F-LANa) (F-LAN-1)
Length = 239
Score = 121 bits (303), Expect = 3e-27
Identities = 67/199 (33%), Positives = 105/199 (52%)
Frame = +1
Query: 91 YRSIPIVSKYWFSGSIIFPLIGKLGLVDPYKMVLMWAPFIEKFQIWRPITALLYYPISPV 270
Y IP VS+ + + ++ +L L+ P+++ + FQIWR IT L++ PV
Sbjct: 10 YLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLFF--GPV 67
Query: 271 SGFHXXXXXXXXXXXXTRLETGTFSGKPADYLFMLIFNWLCLVVIGFIAPLYLLMDPMII 450
GF+ LE G+F G+ AD++FM +F + + G L L I
Sbjct: 68 -GFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFLGQAFTI 126
Query: 451 SVLYVWCQLNKDVIVQFWFGTQFKAMYLPWILLGFNMIISGGGFSDLLGIVVGHLYFFLM 630
++YVW + N V + F+ F+A +LPW+L+GF++++ DLLGI VGH+YFFL
Sbjct: 127 MLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGHIYFFLE 186
Query: 631 FKYPQEFGGNVWLRTPQFL 687
+P + GG L+TP L
Sbjct: 187 DVFPNQPGGIRILKTPSIL 205
>sp|Q8BNI4|DERL2_MOUSE Derlin-2 (Degradation in endoplasmic reticulum protein 2)
(Der1-like protein 2) (F-LANa)
Length = 239
Score = 120 bits (302), Expect = 4e-27
Identities = 67/199 (33%), Positives = 105/199 (52%)
Frame = +1
Query: 91 YRSIPIVSKYWFSGSIIFPLIGKLGLVDPYKMVLMWAPFIEKFQIWRPITALLYYPISPV 270
Y IP VS+ + + ++ +L L+ P+++ + FQIWR IT L++ PV
Sbjct: 10 YLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLFF--GPV 67
Query: 271 SGFHXXXXXXXXXXXXTRLETGTFSGKPADYLFMLIFNWLCLVVIGFIAPLYLLMDPMII 450
GF+ LE G+F G+ AD++FM +F + + G L L I
Sbjct: 68 -GFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFLGQAFTI 126
Query: 451 SVLYVWCQLNKDVIVQFWFGTQFKAMYLPWILLGFNMIISGGGFSDLLGIVVGHLYFFLM 630
++YVW + N V + F+ F+A +LPW+L+GF++++ DLLGI VGH+YFFL
Sbjct: 127 MLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGHIYFFLE 186
Query: 631 FKYPQEFGGNVWLRTPQFL 687
+P + GG L+TP L
Sbjct: 187 DIFPNQPGGIRILKTPSIL 205
>sp|Q96Q80|DERL3_HUMAN Derlin-3 (Degradation in endoplasmic reticulum protein 3)
(Der1-like protein 3) (DERtrin-3)
Length = 235
Score = 119 bits (298), Expect = 1e-26
Identities = 61/199 (30%), Positives = 109/199 (54%)
Frame = +1
Query: 91 YRSIPIVSKYWFSGSIIFPLIGKLGLVDPYKMVLMWAPFIEKFQIWRPITALLYYPISPV 270
+ +P V++ + + ++ +L L+ P+++ KFQ+WR +T L++ P+
Sbjct: 10 FLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTNFLFF--GPL 67
Query: 271 SGFHXXXXXXXXXXXXTRLETGTFSGKPADYLFMLIFNWLCLVVIGFIAPLYLLMDPMII 450
GF LE G+F G+ AD++FM +F + + ++G + L+ L ++
Sbjct: 68 -GFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFLGQALMA 126
Query: 451 SVLYVWCQLNKDVIVQFWFGTQFKAMYLPWILLGFNMIISGGGFSDLLGIVVGHLYFFLM 630
++YVW + + V V F+ F+A +LPW L+GF++++ DLLGI VGH+Y+FL
Sbjct: 127 MLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGHIYYFLE 186
Query: 631 FKYPQEFGGNVWLRTPQFL 687
+P + GG L+TP FL
Sbjct: 187 DVFPNQPGGKRLLQTPGFL 205
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 106,959,576
Number of Sequences: 369166
Number of extensions: 2401566
Number of successful extensions: 5653
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5400
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5640
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8550075140
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)