Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_A20
(850 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8MZR5|HYEP2_CTEFE Juvenile hormone epoxide hydrolase 2 ... 170 5e-42
sp|P07687|HYEP_RAT Epoxide hydrolase 1 (Microsomal epoxide ... 169 1e-41
sp|P04068|HYEP_RABIT Epoxide hydrolase 1 (Microsomal epoxid... 168 2e-41
sp|P07099|HYEP_HUMAN Epoxide hydrolase 1 (Microsomal epoxid... 168 2e-41
sp|Q8MZR6|HYEP1_CTEFE Juvenile hormone epoxide hydrolase 1 ... 167 3e-41
sp|Q9D379|HYEP_MOUSE Epoxide hydrolase 1 (Microsomal epoxid... 166 8e-41
sp|Q25489|HYEP_MANSE Juvenile hormone epoxide hydrolase (Ju... 144 4e-34
sp|O52866|HYES_CORS2 Soluble epoxide hydrolase (SEH) (Epoxi... 42 0.003
sp|P53750|YN93_YEAST Hypothetical 32.8 kDa protein in BIO3-... 41 0.004
sp|P26174|BCHO_RHOCA Magnesium-chelatase 30 kDa subunit (Mg... 38 0.031
>sp|Q8MZR5|HYEP2_CTEFE Juvenile hormone epoxide hydrolase 2 (Juvenile hormone epoxide
hydrolase II) (Juvenile hormone-specific epoxide
hydrolase II) (JHEH II) (CfEH2)
Length = 465
Score = 170 bits (430), Expect = 5e-42
Identities = 87/243 (35%), Positives = 133/243 (54%), Gaps = 4/243 (1%)
Frame = +3
Query: 111 PNVTAKDSWGSRNIN--DKSITEILIKVPIETLSNLFARIKNRVSAPSFSNSDFQYGFNV 284
PN+ WG+ D S+ I + E L+ L ++ + P DFQYGFN
Sbjct: 30 PNIPLDTWWGTGKSQKIDTSMRPFKIAINDEVLNTLKVKLSDVSFTPPLEGIDFQYGFNT 89
Query: 285 EYLNKMMDYWLNKYDWQHWEEVINRFPHRFTIIKGLQIHYIHVXXXXXXXXXXXXXXXXH 464
L K++D+W +Y+W+ E ++N++PH T I+GL IHY+H+ H
Sbjct: 90 NTLKKLVDFWRTQYNWREREALLNKYPHFKTNIQGLDIHYVHIKPQVSKNIHVLPMIMVH 149
Query: 465 GWPGSFFEFYKLIPLLSTQTEKDQYAFEIVCPSLVGYGWSDGATIPGFDLFAMSDVMFTL 644
GWPGSF EFYK+IP+L+T + FE++ PS+ GYG+S A PG ++ +M L
Sbjct: 150 GWPGSFVEFYKIIPMLTTPRTDYNFVFELILPSIPGYGFSQAAAKPGLGATQIAVIMHNL 209
Query: 645 MERLNITSKFYIQGGDFGFIIARSMSVINPKKVAGIHIN--FVETPYHDMRYLTQVFIGS 818
M+R+ K+Y+QGGD+G I +MS + P+ V G H N F+ T +++ F+GS
Sbjct: 210 MDRIGF-KKYYVQGGDWGSRIVSAMSTLFPENVLGHHSNLCFLNTLSSNIK----SFVGS 264
Query: 819 MLP 827
+ P
Sbjct: 265 LFP 267
>sp|P07687|HYEP_RAT Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 169 bits (427), Expect = 1e-41
Identities = 86/229 (37%), Positives = 131/229 (57%), Gaps = 6/229 (2%)
Frame = +3
Query: 156 DKSITEILIKVPIETLSNLFARIKNRVSAPSFSNSDFQYGFNVEYLNKMMDYWLNKYDWQ 335
D+SI ++ E + +L RI ++P S F YGFN Y+ K++ YW N++DW+
Sbjct: 45 DESIRPFKVETSDEEIKDLHQRIDRFRASPPLEGSRFHYGFNSNYMKKVVSYWRNEFDWR 104
Query: 336 HWEEVINRFPHRFTIIKGLQIHYIHV-XXXXXXXXXXXXXXXXHGWPGSFFEFYKLIPLL 512
E++N++PH T I+GL IH+IHV HGWPGSF+EFYK+IPLL
Sbjct: 105 KQVEILNQYPHFKTKIEGLDIHFIHVKPPQLPSGRTPKPLLMVHGWPGSFYEFYKIIPLL 164
Query: 513 STQTE---KDQYAFEIVCPSLVGYGWSDGATIPGFDLFAMSDVMFTLMERLNITSKFYIQ 683
+ D++ FE++CPS+ GYG+S+ ++ G + A + + + LM RL KFYIQ
Sbjct: 165 TDPKSHGLSDEHVFEVICPSIPGYGYSEASSKKGLNSVATARIFYKLMTRLGF-QKFYIQ 223
Query: 684 GGDFGFIIARSMSVINPKKVAGIHIN--FVETPYHDMRYLTQVFIGSML 824
GGD+G +I +M+ + P V G+H+N F+ ++ M L G L
Sbjct: 224 GGDWGSLICTNMAQMVPNHVKGLHLNMAFISRSFYTMTPLLGQRFGRFL 272
>sp|P04068|HYEP_RABIT Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 168 bits (426), Expect = 2e-41
Identities = 86/221 (38%), Positives = 129/221 (58%), Gaps = 9/221 (4%)
Frame = +3
Query: 126 KDSW---GSR--NINDKSITEILIKVPIETLSNLFARIKNRVSAPSFSNSDFQYGFNVEY 290
+D W GSR + D+SI ++ E +++L RI P NS F YGFN Y
Sbjct: 30 EDGWWGPGSRPVGLEDESIRPFKVETSDEEINDLHQRIDRIRLTPPLENSRFHYGFNSNY 89
Query: 291 LNKMMDYWLNKYDWQHWEEVINRFPHRFTIIKGLQIHYIHV-XXXXXXXXXXXXXXXXHG 467
L K++ YW +++DW+ E++N +PH T I+GL IH+IHV HG
Sbjct: 90 LKKILSYWRHEFDWKKQVEILNSYPHFKTKIEGLDIHFIHVKPPQVPPGRTPKPLLMVHG 149
Query: 468 WPGSFFEFYKLIPLLSTQTE---KDQYAFEIVCPSLVGYGWSDGATIPGFDLFAMSDVMF 638
WPGSFFEFYK+IPLL+ D++ FE++CPS+ GYG+S ++ GF+ + + + +
Sbjct: 150 WPGSFFEFYKIIPLLTDPKSHGLSDEHIFEVICPSIPGYGFSQASSKKGFNSVSTARIFY 209
Query: 639 TLMERLNITSKFYIQGGDFGFIIARSMSVINPKKVAGIHIN 761
LM RL +FYIQGGD+G ++ +M+ + P V G+H+N
Sbjct: 210 KLMLRLGF-QEFYIQGGDWGALVCTNMAQLVPSHVKGLHLN 249
>sp|P07099|HYEP_HUMAN Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 168 bits (425), Expect = 2e-41
Identities = 87/221 (39%), Positives = 129/221 (58%), Gaps = 9/221 (4%)
Frame = +3
Query: 126 KDSW---GSRNI--NDKSITEILIKVPIETLSNLFARIKNRVSAPSFSNSDFQYGFNVEY 290
+D W G+R+ D SI ++ E + +L RI P +S F YGFN Y
Sbjct: 30 EDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNY 89
Query: 291 LNKMMDYWLNKYDWQHWEEVINRFPHRFTIIKGLQIHYIHV-XXXXXXXXXXXXXXXXHG 467
L K++ YW N++DW+ E++NR+PH T I+GL IH+IHV HG
Sbjct: 90 LKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHG 149
Query: 468 WPGSFFEFYKLIPLLSTQTE---KDQYAFEIVCPSLVGYGWSDGATIPGFDLFAMSDVMF 638
WPGSF+EFYK+IPLL+ D++ FE++CPS+ GYG+S+ ++ GF+ A + + +
Sbjct: 150 WPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFY 209
Query: 639 TLMERLNITSKFYIQGGDFGFIIARSMSVINPKKVAGIHIN 761
LM RL +FYIQGGD+G +I +M+ + P V G+H+N
Sbjct: 210 KLMLRLGF-QEFYIQGGDWGSLICTNMAQLVPSHVKGLHLN 249
>sp|Q8MZR6|HYEP1_CTEFE Juvenile hormone epoxide hydrolase 1 (Juvenile hormone epoxide
hydrolase I) (Juvenile hormone-specific epoxide
hydrolase I) (JHEH I) (CfEH1)
Length = 464
Score = 167 bits (424), Expect = 3e-41
Identities = 91/261 (34%), Positives = 141/261 (54%), Gaps = 15/261 (5%)
Frame = +3
Query: 111 PNVTAKDSWGS---RNINDKSITEILIKVPIETLSNLFARIKNRVSAPSFSNSDFQYGFN 281
PN+ WG +N+ D SI I + + + NL ++ + +F+YGFN
Sbjct: 30 PNIPLDTWWGPGKPQNV-DISIRPFKININNKVIENLKLKLNDVQYTLPLEGINFEYGFN 88
Query: 282 VEYLNKMMDYWLNKYDWQHWEEVINRFPHRFTIIKGLQIHYIHVXXXXXXXXXXXXXXXX 461
+ L K++D+W +Y+W+ E ++N++PH T I+GL IHY+H+
Sbjct: 89 TDSLKKIVDFWRTQYNWREREALLNKYPHFKTNIQGLDIHYVHIKPQVSKNIEVLPLVMI 148
Query: 462 HGWPGSFFEFYKLIPLLSTQTEKDQYAFEIVCPSLVGYGWSDGATIPGFDLFAMSDVMFT 641
HGWPGSF EFYK+IP+L+T + FE++ PS+ GYG+S A PG ++ +M
Sbjct: 149 HGWPGSFVEFYKIIPMLTTPRAGYNFVFELILPSIPGYGFSQAAAKPGLGSTQVAVIMRN 208
Query: 642 LMERLNITSKFYIQGGDFGFIIARSMSVINPKKVAGIHIN--FVETPYHDMR-----YLT 800
LMER+ K+Y+QGGD+G +I +MS + P+ V G H N FV TP +++ +
Sbjct: 209 LMERIGF-KKYYVQGGDWGSMIISAMSTLFPENVLGQHSNMCFVNTPSSNIKAIIGSFFP 267
Query: 801 QVFIGS-----MLPAKLHFLT 848
+ F G+ M P HF T
Sbjct: 268 ESFAGTGNAHKMYPMSEHFFT 288
>sp|Q9D379|HYEP_MOUSE Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 166 bits (420), Expect = 8e-41
Identities = 81/206 (39%), Positives = 124/206 (60%), Gaps = 4/206 (1%)
Frame = +3
Query: 156 DKSITEILIKVPIETLSNLFARIKNRVSAPSFSNSDFQYGFNVEYLNKMMDYWLNKYDWQ 335
D+SI ++ E + +L RI ++P S F YGFN YL K++ +W N++DW+
Sbjct: 45 DESIRPFKVETSDEEIKDLHQRIDRFRASPPLEGSRFHYGFNSSYLKKVVSFWRNEFDWR 104
Query: 336 HWEEVINRFPHRFTIIKGLQIHYIHV-XXXXXXXXXXXXXXXXHGWPGSFFEFYKLIPLL 512
E++N++PH T I+GL IH+IHV HGWPGSF+EFYK+IPLL
Sbjct: 105 KQVEILNQYPHFKTKIEGLDIHFIHVKPPQLPSGRTPKPLLMVHGWPGSFYEFYKIIPLL 164
Query: 513 S---TQTEKDQYAFEIVCPSLVGYGWSDGATIPGFDLFAMSDVMFTLMERLNITSKFYIQ 683
+ T D++ FE++CPS+ GYG+S+ ++ G + A + + + LM RL KFYIQ
Sbjct: 165 TDPKTHGLSDEHVFEVICPSIPGYGFSEASSKKGLNSVATARIFYKLMSRLGF-QKFYIQ 223
Query: 684 GGDFGFIIARSMSVINPKKVAGIHIN 761
GGD+G +I +++ + P V G+H+N
Sbjct: 224 GGDWGSLICTNIAQMVPNHVKGLHLN 249
>sp|Q25489|HYEP_MANSE Juvenile hormone epoxide hydrolase (Juvenile hormone-specific
epoxide hydrolase) (JHEH)
Length = 462
Score = 144 bits (362), Expect = 4e-34
Identities = 94/273 (34%), Positives = 136/273 (49%), Gaps = 8/273 (2%)
Frame = +3
Query: 36 ISSFALIGGILLNSNCVADLFLSAVPNVTAKDS---WG---SRNINDKSITEILIKVPIE 197
+SSF + G+ + S V L VP D WG DKSI I
Sbjct: 5 LSSF--VAGVAIGSGLVITYVLYNVPEPPELDLQRWWGIGTRPTEEDKSIRPFSIDFNDT 62
Query: 198 TLSNLFARIKNRVS-APSFSNSDFQYGFNVEYLNKMMDYWLNKYDWQHWEEVINRFPHRF 374
+ +L R+KNR + +YG N EYL +++YWLN+Y+++ E++N+FPH
Sbjct: 63 VILDLKERLKNRRPFTKPLEGINSEYGMNTEYLETVLEYWLNEYNFKKRAELLNKFPHYK 122
Query: 375 TIIKGLQIHYIHVXXXXXXXXXXXXXXXXHGWPGSFFEFYKLIPLLSTQTEKDQYAFEIV 554
T I+GL +H+I V HGWP S EF K+IP+L+T + FE+V
Sbjct: 123 TRIQGLDLHFIRVKPEIKEGVQVLPLLMMHGWPSSSKEFDKVIPILTTPKHEYNIVFEVV 182
Query: 555 CPSLVGYGWSDGATIPGFDLFAMSDVMFTLMERLNITSKFYIQGGDFGFIIARSMSVINP 734
L GYG+S+G PG + + +M LM RL KFYIQ GD+G A M+ + P
Sbjct: 183 AVDLPGYGFSEGTNKPGLNPVQIGVMMRNLMLRLGF-EKFYIQAGDWGSQCATHMATLFP 241
Query: 735 KKVAGIHINFVETPYHDMRYLT-QVFIGSMLPA 830
+V G+H N P T ++FIG++ P+
Sbjct: 242 DQVLGLHTNM---PLSSRPLSTVKLFIGALFPS 271
>sp|O52866|HYES_CORS2 Soluble epoxide hydrolase (SEH) (Epoxide hydratase) (Cytosolic
epoxide hydrolase) (cEH)
Length = 286
Score = 41.6 bits (96), Expect = 0.003
Identities = 32/115 (27%), Positives = 51/115 (44%)
Frame = +3
Query: 366 HRFTIIKGLQIHYIHVXXXXXXXXXXXXXXXXHGWPGSFFEFYKLIPLLSTQTEKDQYAF 545
H +I G ++HY+ HGWP S++E+ +IP L+ Q F
Sbjct: 7 HHQAMINGYRMHYVTAGSGYPLVLL-------HGWPQSWYEWRNVIPALAEQ-------F 52
Query: 546 EIVCPSLVGYGWSDGATIPGFDLFAMSDVMFTLMERLNITSKFYIQGGDFGFIIA 710
++ P L G G S+ + GFD M+ + L+ L K + G D+G +A
Sbjct: 53 TVIAPDLRGLGDSE-KPMTGFDKRTMATDVRELVSHLGY-DKVGVIGHDWGGSVA 105
>sp|P53750|YN93_YEAST Hypothetical 32.8 kDa protein in BIO3-HXT17 intergenic region
Length = 290
Score = 41.2 bits (95), Expect = 0.004
Identities = 28/97 (28%), Positives = 50/97 (51%)
Frame = +3
Query: 462 HGWPGSFFEFYKLIPLLSTQTEKDQYAFEIVCPSLVGYGWSDGATIPGFDLFAMSDVMFT 641
HG+P S F LIPLL+ Q F I+ P L G+G+++ F ++ + +
Sbjct: 36 HGFPTSSNMFRNLIPLLAGQ-------FHIIAPDLPGFGFTETPENYKFSFDSLCESIGY 88
Query: 642 LMERLNITSKFYIQGGDFGFIIARSMSVINPKKVAGI 752
L++ L+I KF + D+G + +++ P ++ GI
Sbjct: 89 LLDTLSI-EKFAMYIFDYGSPVGFRLALKFPSRITGI 124
>sp|P26174|BCHO_RHOCA Magnesium-chelatase 30 kDa subunit (Mg-protoporphyrin IX chelatase)
Length = 284
Score = 38.1 bits (87), Expect = 0.031
Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 1/99 (1%)
Frame = +3
Query: 462 HGWPGSFFEFYKLIPLLSTQTEKDQYAFEIVCPSLVGYGWSDGATIPGFDLFAMSDVMFT 641
HG S F K+IP LS + + ++ P L G+G S F L M++ ++
Sbjct: 43 HGLGASGHSFRKMIPGLSAR-------YRVIVPDLPGHGCSRSTARNRFGLKPMAEDLWK 95
Query: 642 LMERLNITSKFYIQGGDFGFIIARSMSVINP-KKVAGIH 755
L + LN+T I G G IA +++ P +V GI+
Sbjct: 96 LCQHLNVTPAAVI-GHSAGGAIALQLALDTPVPRVVGIN 133
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,406,037
Number of Sequences: 369166
Number of extensions: 2146796
Number of successful extensions: 5692
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5502
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5671
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)