Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_O20
(676 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P13444|METL_RAT S-adenosylmethionine synthetase alpha an... 194 2e-49
sp|Q00266|METL_HUMAN S-adenosylmethionine synthetase alpha ... 194 2e-49
sp|P18298|METK_RAT S-adenosylmethionine synthetase gamma fo... 193 4e-49
sp|P31153|METK_HUMAN S-adenosylmethionine synthetase gamma ... 191 2e-48
sp|P40320|METK_DROME S-adenosylmethionine synthetase (Methi... 183 4e-46
sp|P50305|METK_CAEEL Probable S-adenosylmethionine syntheta... 181 1e-45
sp|P50306|METL_CAEEL Probable S-adenosylmethionine syntheta... 178 1e-44
sp|O17680|METM_CAEEL Probable S-adenosylmethionine syntheta... 175 8e-44
sp|Q27522|METN_CAEEL Probable S-adenosylmethionine syntheta... 174 1e-43
sp|P48466|METK_NEUCR S-adenosylmethionine synthetase (Methi... 174 2e-43
>sp|P13444|METL_RAT S-adenosylmethionine synthetase alpha and beta forms (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-I/III)
Length = 397
Score = 194 bits (492), Expect = 2e-49
Identities = 92/130 (70%), Positives = 109/130 (83%), Gaps = 1/130 (0%)
Frame = +2
Query: 251 VTSSYQYLGAHGGGAFSGKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYAIGIAA 430
+ +Y GAHGGGAFSGKDYTKVDRS AYAARWVAKSLVKAGLC+R+LVQ+SYAIG+A
Sbjct: 268 IVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAE 327
Query: 431 PLSIFVDSYGTSSMPD-SKLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFGRSEF 607
PLSI + +YGTS + +LLE++N NFDLRPG I +DLDL+KPIY++TACYGHFGRSEF
Sbjct: 328 PLSISIFTYGTSKKTERDELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEF 387
Query: 608 TWEQPKLLKY 637
WE PK L +
Sbjct: 388 PWEVPKKLVF 397
>sp|Q00266|METL_HUMAN S-adenosylmethionine synthetase alpha and beta forms (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-I/III)
Length = 395
Score = 194 bits (492), Expect = 2e-49
Identities = 89/129 (68%), Positives = 109/129 (84%)
Frame = +2
Query: 251 VTSSYQYLGAHGGGAFSGKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYAIGIAA 430
+ +Y GAHGGGAFSGKDYTKVDRS AYAARWVAKSLVKAGLC+R+LVQ+SYAIG+A
Sbjct: 267 IVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAE 326
Query: 431 PLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFGRSEFT 610
PLSI + +YGTS + +LL++++ NFDLRPG I +DLDL+KPIY++TACYGHFGRSEF
Sbjct: 327 PLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFP 386
Query: 611 WEQPKLLKY 637
WE P+ L +
Sbjct: 387 WEVPRKLVF 395
>sp|P18298|METK_RAT S-adenosylmethionine synthetase gamma form (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-II)
Length = 395
Score = 193 bits (490), Expect = 4e-49
Identities = 91/129 (70%), Positives = 105/129 (81%)
Frame = +2
Query: 251 VTSSYQYLGAHGGGAFSGKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYAIGIAA 430
+ +Y GAHGGGAFSGKDYTKVDRS AYAARWVAKSLVK GLC+R+LVQ+SYAIG++
Sbjct: 267 IVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSH 326
Query: 431 PLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFGRSEFT 610
PLSI + YGTS + +LLEI+ NNFDLRPG I +DLDL+KPIY+RTA YGHFGR F
Sbjct: 327 PLSISIFHYGTSQKSERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFP 386
Query: 611 WEQPKLLKY 637
WE PK LKY
Sbjct: 387 WEVPKKLKY 395
>sp|P31153|METK_HUMAN S-adenosylmethionine synthetase gamma form (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-II)
Length = 395
Score = 191 bits (484), Expect = 2e-48
Identities = 90/129 (69%), Positives = 104/129 (80%)
Frame = +2
Query: 251 VTSSYQYLGAHGGGAFSGKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYAIGIAA 430
+ +Y GAHGGGAFSGKDYTKVDRS AYAARWVAKSLVK GLC+R+LVQ+SYAIG++
Sbjct: 267 IVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSH 326
Query: 431 PLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFGRSEFT 610
PLSI + YGTS + +LLEI+ NFDLRPG I +DLDL+KPIY+RTA YGHFGR F
Sbjct: 327 PLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFP 386
Query: 611 WEQPKLLKY 637
WE PK LKY
Sbjct: 387 WEVPKKLKY 395
>sp|P40320|METK_DROME S-adenosylmethionine synthetase (Methionine adenosyltransferase)
(AdoMet synthetase)
Length = 408
Score = 183 bits (464), Expect = 4e-46
Identities = 89/128 (69%), Positives = 104/128 (81%)
Frame = +2
Query: 251 VTSSYQYLGAHGGGAFSGKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYAIGIAA 430
+ +Y GAHGGGAFSGKD+TKVDRS AYAARWVAKSLVKAGLCKR LVQ+SYAIG+A
Sbjct: 278 IVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAE 337
Query: 431 PLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFGRSEFT 610
PLSI V YGTS +LL+II NFDLRPG I KDL+LR+PIY+RT+ YGHFGR+ F+
Sbjct: 338 PLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFS 397
Query: 611 WEQPKLLK 634
WE+ K L+
Sbjct: 398 WEEAKPLE 405
>sp|P50305|METK_CAEEL Probable S-adenosylmethionine synthetase C06E7.1 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 181 bits (460), Expect = 1e-45
Identities = 87/128 (67%), Positives = 106/128 (82%)
Frame = +2
Query: 251 VTSSYQYLGAHGGGAFSGKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYAIGIAA 430
+ +Y GAHGGGAFSGKD TKVDRS AYAARWVAKSLVK+GLC+R LVQ+SYAIG+A
Sbjct: 255 IVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKSGLCRRCLVQVSYAIGVAK 314
Query: 431 PLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFGRSEFT 610
PLS+ V S+GTS++ + +LL+I+N+NFDLRPG I KDLDL+KPIY TA GHFG +EF
Sbjct: 315 PLSVMVFSFGTSALNEGELLKIVNDNFDLRPGMIIKDLDLKKPIYEPTAENGHFGHNEFP 374
Query: 611 WEQPKLLK 634
WEQP+ L+
Sbjct: 375 WEQPRHLQ 382
>sp|P50306|METL_CAEEL Probable S-adenosylmethionine synthetase C06E7.3 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 178 bits (452), Expect = 1e-44
Identities = 86/128 (67%), Positives = 103/128 (80%)
Frame = +2
Query: 251 VTSSYQYLGAHGGGAFSGKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYAIGIAA 430
+ +Y GAHGGGAFSGKD TKVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A
Sbjct: 255 IVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAK 314
Query: 431 PLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFGRSEFT 610
PLS+ V S+GTS++ + LL I+N+NFDLRPG I K+LDL++PIY TA GHFG + F
Sbjct: 315 PLSVMVFSFGTSALSEEDLLTIVNDNFDLRPGKIIKNLDLKRPIYEPTAENGHFGHNNFP 374
Query: 611 WEQPKLLK 634
WEQP+ LK
Sbjct: 375 WEQPRNLK 382
>sp|O17680|METM_CAEEL Probable S-adenosylmethionine synthetase C49F5.1 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 403
Score = 175 bits (444), Expect = 8e-44
Identities = 85/128 (66%), Positives = 102/128 (79%)
Frame = +2
Query: 251 VTSSYQYLGAHGGGAFSGKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYAIGIAA 430
+ +Y GAHGGGAFSGKD TKVDRS AYAARWVA SLVKAGL KR+LVQLSYAIGIA
Sbjct: 254 IVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVATSLVKAGLAKRVLVQLSYAIGIAK 313
Query: 431 PLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFGRSEFT 610
P+S+ V ++GTS + D +L +I+ ++FDL PG I K+LDL++PIY +TA GHFG SEF
Sbjct: 314 PISVLVYAFGTSPLTDEELHQIVEDSFDLTPGKIIKELDLKRPIYEKTAENGHFGHSEFP 373
Query: 611 WEQPKLLK 634
WEQPK LK
Sbjct: 374 WEQPKALK 381
>sp|Q27522|METN_CAEEL Probable S-adenosylmethionine synthetase T13A10.11 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 174 bits (442), Expect = 1e-43
Identities = 84/128 (65%), Positives = 105/128 (82%)
Frame = +2
Query: 251 VTSSYQYLGAHGGGAFSGKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYAIGIAA 430
+ +Y GAHGGGAFSGKD TKVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A
Sbjct: 255 IVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAK 314
Query: 431 PLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFGRSEFT 610
PLS+ V S+GTS++ +++LL+I+N+NFDLRPG I K+LDL++ IY TA GHFG ++F
Sbjct: 315 PLSVMVFSFGTSALNEAELLKIVNDNFDLRPGMIIKNLDLKRAIYEPTAENGHFGHNDFP 374
Query: 611 WEQPKLLK 634
WEQ + LK
Sbjct: 375 WEQARKLK 382
>sp|P48466|METK_NEUCR S-adenosylmethionine synthetase (Methionine adenosyltransferase)
(AdoMet synthetase)
Length = 395
Score = 174 bits (440), Expect = 2e-43
Identities = 84/130 (64%), Positives = 103/130 (79%), Gaps = 1/130 (0%)
Frame = +2
Query: 251 VTSSYQYLGAHGGGAFSGKDYTKVDRSGAYAARWVAKSLVKAGLCKRILVQLSYAIGIAA 430
+ +Y GAHGGGAFSGKD++KVDRS AY RW+AKSLV AGL +R LVQLSYAIG+A
Sbjct: 266 IVDTYGGWGAHGGGAFSGKDFSKVDRSAAYVGRWIAKSLVAAGLARRALVQLSYAIGVAE 325
Query: 431 PLSIFVDSYGTSSMPDSKLLEIINNNFDLRPGHIEKDLDLRKPIYRRTACYGHFGRSE-F 607
PLSI+VD+YGTS +L++II NNFDLRPG I K+LDL KPIY +TA GHFG ++ F
Sbjct: 326 PLSIYVDTYGTSDKTSEELVQIIRNNFDLRPGVIVKELDLAKPIYLQTAKNGHFGTNQSF 385
Query: 608 TWEQPKLLKY 637
+WE+PK LK+
Sbjct: 386 SWEKPKALKF 395
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,806,662
Number of Sequences: 369166
Number of extensions: 1728283
Number of successful extensions: 4257
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4089
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4205
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5684835195
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)