Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_O14
(513 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 185 5e-47
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 185 5e-47
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 184 8e-47
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 182 4e-46
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 176 2e-44
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 176 3e-44
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 175 6e-44
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 175 6e-44
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 172 4e-43
sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precu... 172 5e-43
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 185 bits (470), Expect = 5e-47
Identities = 90/150 (60%), Positives = 105/150 (70%), Gaps = 2/150 (1%)
Frame = +1
Query: 1 LMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVA 177
LMDNAFRYIKD G I++E YPY D +C N + I TGF DI +E + AVA
Sbjct: 190 LMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVA 249
Query: 178 TVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWD 354
T+GPVSVAIDA H SFQLY G+YNE C LDHGVL VGYGT + G YW+VKNSW
Sbjct: 250 TMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWG 309
Query: 355 VTWGESGYIKMSKDKKNQCGIATMASYPLV 444
TWGE GYIKM++++ NQCGIAT +SYP V
Sbjct: 310 TTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 185 bits (470), Expect = 5e-47
Identities = 89/150 (59%), Positives = 107/150 (71%), Gaps = 2/150 (1%)
Frame = +1
Query: 1 LMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVA 177
LMDNAFRYIKD G I++E YPY A D +C N + GFTDI +E +A AVA
Sbjct: 192 LMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVA 251
Query: 178 TVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWD 354
TVGPVSVAIDA H SFQ Y G+YNE C LDHGVL VG+GT + G+ YW+VKNSW
Sbjct: 252 TVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWG 311
Query: 355 VTWGESGYIKMSKDKKNQCGIATMASYPLV 444
TWG+ G+IKM ++K+NQCGIA+ +SYPLV
Sbjct: 312 TTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 184 bits (468), Expect = 8e-47
Identities = 92/150 (61%), Positives = 106/150 (70%), Gaps = 2/150 (1%)
Frame = +1
Query: 1 LMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVA 177
LMDNAF+YIK+ G ++SE YPY ATD +C P K TGF DI Q E L AVA
Sbjct: 69 LMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDIP-QREKALMKAVA 127
Query: 178 TVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKYWIVKNSWD 354
TVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+WIVKNSW
Sbjct: 128 TVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWG 187
Query: 355 VTWGESGYIKMSKDKKNQCGIATMASYPLV 444
WG GY+KM+KD+ N CGIAT ASYP V
Sbjct: 188 PEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 182 bits (462), Expect = 4e-46
Identities = 82/148 (55%), Positives = 112/148 (75%), Gaps = 1/148 (0%)
Frame = +1
Query: 4 MDNAFRYIK-DQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVAT 180
M++AF YIK + GI++E YPY A DG+C+ + + + C+G T+I S +ET L AV
Sbjct: 176 MNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRD 235
Query: 181 VGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVT 360
+GP+SV IDA H+SFQ Y SG+Y E SCS + LDH VLAVGYG++ G+ +W+VKNSW +
Sbjct: 236 IGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATS 295
Query: 361 WGESGYIKMSKDKKNQCGIATMASYPLV 444
WG++GYIKMS+++ N CGIAT+ASYPLV
Sbjct: 296 WGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 176 bits (447), Expect = 2e-44
Identities = 88/153 (57%), Positives = 105/153 (68%), Gaps = 5/153 (3%)
Frame = +1
Query: 1 LMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVA 177
LMD AF+Y++D G ++SE YPY AT+ +CK NP V TGF DI Q E L AVA
Sbjct: 182 LMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVA 240
Query: 178 TVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQI----GKKYWIVKN 345
TVGP+SVAIDAGH SF YK GIY E CS+ +DHGVL VGYG + KYW+VKN
Sbjct: 241 TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN 300
Query: 346 SWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 444
SW WG GY+KM+KD++N CGIA+ ASYP V
Sbjct: 301 SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 176 bits (446), Expect = 3e-44
Identities = 92/154 (59%), Positives = 104/154 (67%), Gaps = 6/154 (3%)
Frame = +1
Query: 1 LMDNAFRYIKDQG-IESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAV 174
LMDNAF+YIKD G ++SE YPY ATD +C P TGF DI Q E L AV
Sbjct: 182 LMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIP-QREKALMKAV 240
Query: 175 ATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVK 342
ATVGP+SVAIDAGH SFQ YKSGIY + CS LDHGVL VGYG + K+WIVK
Sbjct: 241 ATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVK 300
Query: 343 NSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 444
NSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 301 NSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 175 bits (443), Expect = 6e-44
Identities = 86/152 (56%), Positives = 101/152 (66%), Gaps = 5/152 (3%)
Frame = +1
Query: 4 MDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVAT 180
M AF+Y+K+ G ++SE YPY A D CK P V TGFT + E L AVAT
Sbjct: 183 MARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVAT 242
Query: 181 VGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG----TQIGKKYWIVKNS 348
VGP+SVA+DAGH+SFQ YKSGIY E CS+ LDHGVL VGYG KYW+VKNS
Sbjct: 243 VGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNS 302
Query: 349 WDVTWGESGYIKMSKDKKNQCGIATMASYPLV 444
W WG +GY+K++KDK N CGIAT ASYP V
Sbjct: 303 WGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 175 bits (443), Expect = 6e-44
Identities = 90/153 (58%), Positives = 103/153 (67%), Gaps = 5/153 (3%)
Frame = +1
Query: 1 LMDNAFRYIKDQG-IESEGDYPYTATDG-TCKRNPSKIVTKCTGFTDIQSQNETDLANAV 174
LMDNAFRY+KD G ++SE YPY D TC P TGF D+ Q E L AV
Sbjct: 182 LMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLP-QREKALMKAV 240
Query: 175 ATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIGKKYWIVKN 345
AT+GP+SVAIDAGH SFQ YKSGIY + CS+ LDHGVL VGY GT K+WIVKN
Sbjct: 241 ATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKN 300
Query: 346 SWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 444
SW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 301 SWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 172 bits (436), Expect = 4e-43
Identities = 83/148 (56%), Positives = 106/148 (71%), Gaps = 1/148 (0%)
Frame = +1
Query: 4 MDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVAT 180
M +AF YIKD G I++E YPY A D +C+ + + I CTG ++Q E L AV+
Sbjct: 175 MTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSVEVQHTEEA-LQEAVSG 233
Query: 181 VGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVT 360
VGP+SVAIDA H SFQ Y SG+Y E++CS T LDHGVLAVGYGT+ K YW+VKNSW +
Sbjct: 234 VGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSS 293
Query: 361 WGESGYIKMSKDKKNQCGIATMASYPLV 444
WG++GYIKMS+++ N CGIA+ SYP V
Sbjct: 294 WGDAGYIKMSRNRDNNCGIASEPSYPTV 321
>sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precursor
Length = 322
Score = 172 bits (435), Expect = 5e-43
Identities = 77/148 (52%), Positives = 105/148 (70%), Gaps = 1/148 (0%)
Frame = +1
Query: 4 MDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVAT 180
++ A Y++D G +++E YPY A D TC+ N + I CTG+ I +E+ L A
Sbjct: 175 VERAIMYVRDNGGVDTESSYPYEARDNTCRFNSNTIGATCTGYVGIAQGSESALKTATRD 234
Query: 181 VGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVT 360
+GP+SVAIDA H SFQ Y +G+Y E SCS++QLDH VLAVGYG++ G+ +W+VKNSW +
Sbjct: 235 IGPISVAIDASHRSFQSYYTGVYYEPSCSSSQLDHAVLAVGYGSEGGQDFWLVKNSWATS 294
Query: 361 WGESGYIKMSKDKKNQCGIATMASYPLV 444
WGESGYIKM++++ N CGIAT A YP V
Sbjct: 295 WGESGYIKMARNRNNNCGIATDACYPTV 322
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,096,933
Number of Sequences: 369166
Number of extensions: 1203058
Number of successful extensions: 3766
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3389
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3465
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3304927425
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)