Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_O12
(881 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q6ZWX6|IF2A_MOUSE Eukaryotic translation initiation fact... 269 9e-72
sp|P05198|IF2A_HUMAN Eukaryotic translation initiation fact... 266 4e-71
sp|P41374|IF2A_DROME Eukaryotic translation initiation fact... 249 9e-66
sp|P56286|IF2A_SCHPO Eukaryotic translation initiation fact... 193 5e-49
sp|P20459|IF2A_YEAST Eukaryotic translation initiation fact... 192 1e-48
sp|Q8TY86|IF2A_METKA Translation initiation factor 2 alpha ... 69 2e-11
sp|Q8U1R5|IF2A_PYRFU Translation initiation factor 2 alpha ... 65 2e-10
sp|Q57581|IF2A_METJA Translation initiation factor 2 alpha ... 63 1e-09
sp|Q973G0|IF2A_SULTO Translation initiation factor 2 alpha ... 63 1e-09
sp|Q5JE49|IF2A_PYRKO Translation initiation factor 2 alpha ... 62 3e-09
>sp|Q6ZWX6|IF2A_MOUSE Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic
translation initiation factor 2 alpha subunit)
(eIF-2-alpha) (EIF-2alpha) (EIF-2A)
sp|P68101|IF2A_RAT Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic
translation initiation factor 2 alpha subunit)
(eIF-2-alpha) (EIF-2alpha) (EIF-2A)
sp|P68102|IF2A_BOVIN Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic
translation initiation factor 2 alpha subunit)
(eIF-2-alpha) (EIF-2alpha) (EIF-2A)
Length = 315
Score = 269 bits (687), Expect = 9e-72
Identities = 135/243 (55%), Positives = 179/243 (73%), Gaps = 1/243 (0%)
Frame = +3
Query: 3 RIRSVNKLLRVGRNEVVSVIRVDADKKYIDLSKRQVSAEEITRCEEKFANSKTVNQILRR 182
RIRS+NKL+R+GRNE V VIRVD +K YIDLSKR+VS EE +CE+KF SKTV ILR
Sbjct: 55 RIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRH 114
Query: 183 LAEELKFETDEQLEDLFNKTAWFFDRKYSRKG-ASFDVFKQAVTNPEVLDECGLENSVKE 359
+AE L++ DEQLE LF +TAW FD KY R G ++D FK AV++P +LD L +E
Sbjct: 115 VAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDERE 174
Query: 360 KLLADINRRMMPQAVKIRSDFEVSCFTFEGIDAIKHALRKGLDMSSKELEIKINLIQSPQ 539
L+ +INRR+ PQAVKIR+D EV+C+ +EGIDA+K ALR GL+ S++ + IKINLI P+
Sbjct: 175 VLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPPR 234
Query: 540 FMMTCQTLDKEKGLSTLNEAIRVIREAIESKKGSFKLLEQPKVVSDHDEQNLKKRLAELE 719
++MT TL++ +GLS LN+A+ VI+E IE K+G F + +PKVV+D DE L ++L LE
Sbjct: 235 YVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLE 294
Query: 720 EAN 728
N
Sbjct: 295 REN 297
>sp|P05198|IF2A_HUMAN Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic
translation initiation factor 2 alpha subunit)
(eIF-2-alpha) (EIF-2alpha) (EIF-2A)
Length = 315
Score = 266 bits (681), Expect = 4e-71
Identities = 133/243 (54%), Positives = 179/243 (73%), Gaps = 1/243 (0%)
Frame = +3
Query: 3 RIRSVNKLLRVGRNEVVSVIRVDADKKYIDLSKRQVSAEEITRCEEKFANSKTVNQILRR 182
RIRS+NKL+R+GRNE V VIRVD +K YIDLSKR+VS EE +CE+KF SKTV ILR
Sbjct: 55 RIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRH 114
Query: 183 LAEELKFETDEQLEDLFNKTAWFFDRKYSRKG-ASFDVFKQAVTNPEVLDECGLENSVKE 359
+AE L++ DEQLE LF +TAW FD KY R G ++D FK AV++P +LD L +E
Sbjct: 115 VAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDERE 174
Query: 360 KLLADINRRMMPQAVKIRSDFEVSCFTFEGIDAIKHALRKGLDMSSKELEIKINLIQSPQ 539
L+ +INRR+ PQAVKIR+D EV+C+ +EGIDA+K ALR GL+ S++ + IKINLI P+
Sbjct: 175 VLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPR 234
Query: 540 FMMTCQTLDKEKGLSTLNEAIRVIREAIESKKGSFKLLEQPKVVSDHDEQNLKKRLAELE 719
++MT TL++ +GLS L++A+ VI+E IE K+G F + +PKVV+D DE L +++ LE
Sbjct: 235 YVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLE 294
Query: 720 EAN 728
N
Sbjct: 295 REN 297
>sp|P41374|IF2A_DROME Eukaryotic translation initiation factor 2 alpha subunit
(eIF-2-alpha)
Length = 341
Score = 249 bits (635), Expect = 9e-66
Identities = 123/242 (50%), Positives = 171/242 (70%)
Frame = +3
Query: 3 RIRSVNKLLRVGRNEVVSVIRVDADKKYIDLSKRQVSAEEITRCEEKFANSKTVNQILRR 182
RIRS+NKL+RVG+ E V VIRVD +K YIDLSKR+VS E++ +C E+FA +K +N +LR
Sbjct: 54 RIRSINKLIRVGKTEPVVVIRVDKEKGYIDLSKRRVSPEDVEKCTERFAKAKAINSLLRH 113
Query: 183 LAEELKFETDEQLEDLFNKTAWFFDRKYSRKGASFDVFKQAVTNPEVLDECGLENSVKEK 362
+A+ L FE +E+LEDL+ KTAW F++KY+ K ++D+FKQ+VT+P V DEC LE KE
Sbjct: 114 VADILGFEGNEKLEDLYQKTAWHFEKKYNNKTVAYDIFKQSVTDPTVFDECNLEPETKEV 173
Query: 363 LLADINRRMMPQAVKIRSDFEVSCFTFEGIDAIKHALRKGLDMSSKELEIKINLIQSPQF 542
LL++I R+++ VKIR+D E SC+ +EGIDA+K +L KGL++S++EL I+INLI P +
Sbjct: 174 LLSNIKRKLVSPTVKIRADIECSCYGYEGIDAVKASLTKGLELSTEELPIRINLIAPPLY 233
Query: 543 MMTCQTLDKEKGLSTLNEAIRVIREAIESKKGSFKLLEQPKVVSDHDEQNLKKRLAELEE 722
+MT T K GL L AI IR G FK++ PK+V+ DE +L +RL E
Sbjct: 234 VMTTSTTKKTDGLKALEVAIEHIRAKTSEYDGEFKVIMAPKLVTAIDEADLARRLERAEA 293
Query: 723 AN 728
N
Sbjct: 294 EN 295
>sp|P56286|IF2A_SCHPO Eukaryotic translation initiation factor 2 alpha subunit
(eIF-2-alpha)
Length = 306
Score = 193 bits (491), Expect = 5e-49
Identities = 109/245 (44%), Positives = 158/245 (64%), Gaps = 3/245 (1%)
Frame = +3
Query: 3 RIRSVNKLLRVGRNEVVSVIRVDADKKYIDLSKRQVSAEEITRCEEKFANSKTVNQILRR 182
RIRSV K +RVGRNEVV V+RVD +K YIDLSKR+VS E++ +CEE+F SK V+ I+R
Sbjct: 55 RIRSVQKHIRVGRNEVVVVLRVDKEKGYIDLSKRRVSPEDVVKCEERFNKSKAVHSIMRH 114
Query: 183 LAEELKFETDEQLEDLFNKTAWFFDRKYSRKGASFDVFKQAVTNPEVLDECGLE---NSV 353
+AE+ + LE ++ W RKY G ++D FK A++NP+ + E GLE + V
Sbjct: 115 IAEK----HNVPLETMYTTIGWPLYRKY---GHAYDAFKLAISNPDHVFE-GLEPPKSGV 166
Query: 354 KEKLLADINRRMMPQAVKIRSDFEVSCFTFEGIDAIKHALRKGLDMSSKELEIKINLIQS 533
LLA I+RR+ PQ +KIR+D EV+CF +EGI+AIK AL+ D+ ++E+ IK+ L+
Sbjct: 167 INDLLAQISRRLTPQPIKIRADVEVTCFGYEGINAIKAALKAAEDVHTEEVPIKVKLVAP 226
Query: 534 PQFMMTCQTLDKEKGLSTLNEAIRVIREAIESKKGSFKLLEQPKVVSDHDEQNLKKRLAE 713
P +++ LDK GL L EAI I ++I + G+ + +PK VS+ DE L + +
Sbjct: 227 PLYVLLTNALDKSLGLKKLEEAIGAIEKSITASNGTCTVKMKPKAVSETDELELADLMKK 286
Query: 714 LEEAN 728
E+ N
Sbjct: 287 FEKEN 291
>sp|P20459|IF2A_YEAST Eukaryotic translation initiation factor 2 alpha subunit
(eIF-2-alpha)
Length = 304
Score = 192 bits (488), Expect = 1e-48
Identities = 107/246 (43%), Positives = 162/246 (65%), Gaps = 3/246 (1%)
Frame = +3
Query: 3 RIRSVNKLLRVGRNEVVSVIRVDADKKYIDLSKRQVSAEEITRCEEKFANSKTVNQILRR 182
RIRS+ KL+RVG+N+V V+RVD +K YIDLSKR+VS+E+I +CEEK+ SKTV+ ILR
Sbjct: 55 RIRSIQKLIRVGKNDVAVVLRVDKEKGYIDLSKRRVSSEDIIKCEEKYQKSKTVHSILRY 114
Query: 183 LAEELKFETDEQLEDLFNKTAWFFDRKYSRKGASFDVFKQAVTNPEVLDECGLE---NSV 353
AE+ + LE+L+ AW RK+ G +++ FK ++ + V + G+E V
Sbjct: 115 CAEKFQIP----LEELYKTIAWPLSRKF---GHAYEAFKLSIIDETVWE--GIEPPSKDV 165
Query: 354 KEKLLADINRRMMPQAVKIRSDFEVSCFTFEGIDAIKHALRKGLDMSSKELEIKINLIQS 533
++L I++R+ PQAVKIR+D EVSCF++EGIDAIK AL+ DMS++++++K+ L+ +
Sbjct: 166 LDELKNYISKRLTPQAVKIRADVEVSCFSYEGIDAIKDALKSAEDMSTEQMQVKVKLVAA 225
Query: 534 PQFMMTCQTLDKEKGLSTLNEAIRVIREAIESKKGSFKLLEQPKVVSDHDEQNLKKRLAE 713
P +++T Q LDK+KG+ L AI I E I G + PK V+ ++ L + L E
Sbjct: 226 PLYVLTTQALDKQKGIEQLESAIEKITEVITKYGGVCNITMPPKAVTATEDAEL-QALLE 284
Query: 714 LEEANN 731
+E +N
Sbjct: 285 SKELDN 290
>sp|Q8TY86|IF2A_METKA Translation initiation factor 2 alpha subunit (eIF-2-alpha)
(aIF2-alpha)
Length = 267
Score = 68.6 bits (166), Expect = 2e-11
Identities = 47/213 (22%), Positives = 99/213 (46%), Gaps = 2/213 (0%)
Frame = +3
Query: 6 IRSVNKLLRVGRNEVVSVIRVDADKKYIDLSKRQVSAEEITRCEEKFANSKTVNQILRRL 185
++++ ++ G+ V VIRV+ +KY +LS R+V+ + +++ + ++L
Sbjct: 51 VKNIRDYVKEGQKVVAKVIRVNPKRKYANLSLRKVTDHQRKEKLKEWKREQRAEKLLEMA 110
Query: 186 AEELKFETDEQLEDLFNKTAWFFDRKYSRKGASFDVFKQAVTN--PEVLDECGLENSVKE 359
AEEL + DE E+ K G+ +D ++A PE L + G+ E
Sbjct: 111 AEELGKDLDEAYEEAGYKLI-------EEYGSLYDALERAAAEEGPEPLLKAGVPEEWAE 163
Query: 360 KLLADINRRMMPQAVKIRSDFEVSCFTFEGIDAIKHALRKGLDMSSKELEIKINLIQSPQ 539
KL + P VKI + +++C G++ I+ AL K + ++++++ + +P+
Sbjct: 164 KLAELAIENIEPGRVKIEAYVDLTCPAPNGVEIIREALEKIEEFQQGDVKMEVQYVGAPR 223
Query: 540 FMMTCQTLDKEKGLSTLNEAIRVIREAIESKKG 638
+ +T D + +A + + +E G
Sbjct: 224 YRITVDAPDYRTAEKMVRKAAQAAIDHVEEHGG 256
>sp|Q8U1R5|IF2A_PYRFU Translation initiation factor 2 alpha subunit (eIF-2-alpha)
(aIF2-alpha)
Length = 275
Score = 65.1 bits (157), Expect = 2e-10
Identities = 57/237 (24%), Positives = 109/237 (45%), Gaps = 4/237 (1%)
Frame = +3
Query: 6 IRSVNKLLRVGRNEVVSVIRVDADKKYIDLSKRQVSAEEITRCEEKFANSKTVNQILRRL 185
++++ LR G+ V VIRVD K +IDLS R+V+ ++ ++F ++ +L+
Sbjct: 51 VKNIRDYLREGQKVVAKVIRVDPKKGHIDLSLRRVTQQQRKAKLQEFKRAQKAENLLKLA 110
Query: 186 AEELKFETDEQLEDLF--NKTAWFFDRKYSRKGASFDVFKQAVTNPEVLDECGLENSVKE 359
AE+L + +E +++ + W G + F+ A N + + + +
Sbjct: 111 AEKLGKDFEEAWREVWVPLENEW---------GEVYAAFEDAARNGIEVLKGYVPDEWLP 161
Query: 360 KLLADINRRMMPQAVKIRSDFEVSCFTFEGIDAIKHALRKGLDMSS--KELEIKINLIQS 533
L I+ + V I ++FE++ GI+ IK AL K D ++ K++E+K + +
Sbjct: 162 VLKEIIDSYVEVPTVTIDAEFEITVPKPNGIEIIKEALIKARDRANQEKDIEVKFTYLGA 221
Query: 534 PQFMMTCQTLDKEKGLSTLNEAIRVIREAIESKKGSFKLLEQPKVVSDHDEQNLKKR 704
P++ + D K L + I I+ G LL + K + + +KKR
Sbjct: 222 PRYRIDITAPDYYKAEEVLEDIAEEILRVIKEAGGEATLLRKEKRI-----RKVKKR 273
>sp|Q57581|IF2A_METJA Translation initiation factor 2 alpha subunit (eIF-2-alpha)
(aIF2-alpha)
Length = 266
Score = 62.8 bits (151), Expect = 1e-09
Identities = 43/192 (22%), Positives = 94/192 (48%), Gaps = 1/192 (0%)
Frame = +3
Query: 6 IRSVNKLLRVGRNEVVSVIRVDADKKYIDLSKRQVSAEEITRCEEKFANSKTVNQILRRL 185
++++ ++VG+ V V+RVD K +IDLS ++V+ ++ +++ + +++L R
Sbjct: 51 VKNIRDHVKVGQRVVAKVLRVDERKGHIDLSLKRVTEQQKRAKVQEWKRFQRASKMLERA 110
Query: 186 AEELKFETDEQLEDLFNKTAWFFDRKYSRKGASFDVFKQAVTNPEVLDECGLENSVKEKL 365
AE+L + LE+ + + + + ++ +F+ + EVLD+ + K L
Sbjct: 111 AEKL----GKSLEEAWEEVGYLLEDEFGELYNAFET--MVIEGKEVLDDLEISEEWKNVL 164
Query: 366 LADINRRMMPQAVKIRSDFEVSCFTFEGIDAIKHALRKGLDMSS-KELEIKINLIQSPQF 542
+ V++ E+ + +GI IK AL L + +++E+KI I +P++
Sbjct: 165 YEVAKESIELTNVEVEGVIEMKSYAPDGIKQIKKALTTALKANPYEDVEVKITYIGAPKY 224
Query: 543 MMTCQTLDKEKG 578
+ D + G
Sbjct: 225 RVVVIAPDYKSG 236
>sp|Q973G0|IF2A_SULTO Translation initiation factor 2 alpha subunit (eIF-2-alpha)
(aIF2-alpha)
Length = 263
Score = 62.8 bits (151), Expect = 1e-09
Identities = 50/220 (22%), Positives = 109/220 (49%), Gaps = 2/220 (0%)
Frame = +3
Query: 6 IRSVNKLLRVGRNEVVSVIRVDADKKYIDLSKRQVSAEEITRCEEKFANSKTVNQILRRL 185
++++ +++ GR VV VIRVD K ID+S ++V+ +E + ++ + V++IL +
Sbjct: 51 VKNIRDVIKEGRKIVVKVIRVDKRKGTIDVSLKKVTEDEKRKKMSQWKKIQKVDKILEIV 110
Query: 186 AEELKFETDEQLEDLFNKTAWFFDRKYSRKGASFDVFKQAVTNPE-VLDECGLENSVKEK 362
++++ E E + AW + KY G ++D +AV + +L G+ +
Sbjct: 111 SQKINKTEKEGWEQV----AWKLEDKY---GDAYDALVKAVKEGDSILKNAGVPEVWIKP 163
Query: 363 LLADINRRMMPQAVKIRSDFEVSCFTFEGIDAIKHALRKGLDMSSK-ELEIKINLIQSPQ 539
L+ +I + + + VK + GI+ I+ L ++++ +++IKI I +P+
Sbjct: 164 LMEEIGKHIEEKRVKKSEIVTLRSSDPAGIEKIRKVLGAAVEIAENADVDIKIYTIGAPR 223
Query: 540 FMMTCQTLDKEKGLSTLNEAIRVIREAIESKKGSFKLLEQ 659
+ + D + + E + IRE + +K F ++ +
Sbjct: 224 YRIDIIGTDPKLLSKVMTEILDNIREISKEEKVEFNVVRK 263
>sp|Q5JE49|IF2A_PYRKO Translation initiation factor 2 alpha subunit (eIF-2-alpha)
(aIF2-alpha)
Length = 275
Score = 61.6 bits (148), Expect = 3e-09
Identities = 54/235 (22%), Positives = 109/235 (46%), Gaps = 2/235 (0%)
Frame = +3
Query: 6 IRSVNKLLRVGRNEVVSVIRVDADKKYIDLSKRQVSAEEITRCEEKFANSKTVNQILRRL 185
++++ L+ G+ V VIRVD +K +IDLS ++V+ ++ +++ ++ +L+
Sbjct: 51 VKNIRDYLKEGQKIVAKVIRVDPEKGHIDLSLKRVNQQQRKAKLQEYKRAQKAENLLKMA 110
Query: 186 AEELKFETDEQLEDLFNKTAWFFDRKYSRKGASFDVFKQAVTNPEVLDECGLENSVKEKL 365
AE+L + E + + + +Y G + F+ A N + + + + E L
Sbjct: 111 AEKL----GKDFETAWREVWVPLEEEY---GEVYAAFEDAAQNGMDVLKGLISDEWIEAL 163
Query: 366 LADINRRMMPQAVKIRSDFEVSCFTFEGIDAIKHALRKGLDMSS--KELEIKINLIQSPQ 539
I + V I ++FE++ GI+ IK AL K D ++ K++E+K + +P+
Sbjct: 164 KPIIEAYVEIPTVTIDAEFEITVPKPNGIEIIKEALIKARDRANQEKDIEVKFSYQGAPR 223
Query: 540 FMMTCQTLDKEKGLSTLNEAIRVIREAIESKKGSFKLLEQPKVVSDHDEQNLKKR 704
+ + D K L + I I+ G L+ + K + + +KKR
Sbjct: 224 YRIDITAPDYYKAEEVLEDIAEEILRVIKEAGGEATLIRKEKRI-----KKVKKR 273
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,544,856
Number of Sequences: 369166
Number of extensions: 1648410
Number of successful extensions: 5855
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5630
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5843
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8790245790
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)